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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PIK3CB-ESYT3 (FusionGDB2 ID:65372)

Fusion Gene Summary for PIK3CB-ESYT3

check button Fusion gene summary
Fusion gene informationFusion gene name: PIK3CB-ESYT3
Fusion gene ID: 65372
HgeneTgene
Gene symbol

PIK3CB

ESYT3

Gene ID

5291

83850

Gene namephosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit betaextended synaptotagmin 3
SynonymsP110BETA|PI3K|PI3KBETA|PIK3C1CHR3SYT|E-Syt3|FAM62C
Cytomap

3q22.3

3q22.3

Type of geneprotein-codingprotein-coding
Descriptionphosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoformPI3-kinase p110 subunit betaPI3-kinase subunit betaPI3K-betaPtdIns-3-kinase p110phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit betaphosphoinositidextended synaptotagmin-3chr3 synaptotagminextended synaptotagmin protein 3family with sequence similarity 62 (C2 domain containing), member C
Modification date2020031320200313
UniProtAcc.

A0FGR9

Ensembl transtripts involved in fusion geneENST00000289153, ENST00000477593, 
ENST00000544716, 		ENST00000460133, 
ENST00000289135, ENST00000389567, 
Fusion gene scores* DoF score15 X 13 X 11=21453 X 3 X 3=27
# samples 173
** MAII scorelog2(17/2145*10)=-3.65737099624921
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PIK3CB [Title/Abstract] AND ESYT3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPIK3CB(138400809)-ESYT3(138176410), # samples:1
Anticipated loss of major functional domain due to fusion event.PIK3CB-ESYT3 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
PIK3CB-ESYT3 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
PIK3CB-ESYT3 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePIK3CB

GO:0016310

phosphorylation

25327288


check buttonFusion gene breakpoints across PIK3CB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ESYT3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CESCTCGA-MA-AA43-01APIK3CBchr3

138400809

-ESYT3chr3

138176410

+


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Fusion Gene ORF analysis for PIK3CB-ESYT3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000289153ENST00000460133PIK3CBchr3

138400809

-ESYT3chr3

138176410

+
5CDS-intronENST00000477593ENST00000460133PIK3CBchr3

138400809

-ESYT3chr3

138176410

+
5CDS-intronENST00000544716ENST00000460133PIK3CBchr3

138400809

-ESYT3chr3

138176410

+
Frame-shiftENST00000289153ENST00000289135PIK3CBchr3

138400809

-ESYT3chr3

138176410

+
Frame-shiftENST00000289153ENST00000389567PIK3CBchr3

138400809

-ESYT3chr3

138176410

+
In-frameENST00000477593ENST00000289135PIK3CBchr3

138400809

-ESYT3chr3

138176410

+
In-frameENST00000477593ENST00000389567PIK3CBchr3

138400809

-ESYT3chr3

138176410

+
In-frameENST00000544716ENST00000289135PIK3CBchr3

138400809

-ESYT3chr3

138176410

+
In-frameENST00000544716ENST00000389567PIK3CBchr3

138400809

-ESYT3chr3

138176410

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000477593PIK3CBchr3138400809-ENST00000389567ESYT3chr3138176410+62952578742635853
ENST00000477593PIK3CBchr3138400809-ENST00000289135ESYT3chr3138176410+32562578742635853
ENST00000544716PIK3CBchr3138400809-ENST00000389567ESYT3chr3138176410+4822110510123261749
ENST00000544716PIK3CBchr3138400809-ENST00000289135ESYT3chr3138176410+178311051131162349

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000477593ENST00000389567PIK3CBchr3138400809-ESYT3chr3138176410+0.0002716030.9997284
ENST00000477593ENST00000289135PIK3CBchr3138400809-ESYT3chr3138176410+0.0001764250.99982363
ENST00000544716ENST00000389567PIK3CBchr3138400809-ESYT3chr3138176410+0.0011214160.99887854
ENST00000544716ENST00000289135PIK3CBchr3138400809-ESYT3chr3138176410+0.0006884680.99931157

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Fusion Genomic Features for PIK3CB-ESYT3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PIK3CBchr3138400808-ESYT3chr3138176409+0.0085988410.99140114
PIK3CBchr3138400808-ESYT3chr3138176409+0.0085988410.99140114

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PIK3CB-ESYT3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:138400809/chr3:138176410)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ESYT3

A0FGR9

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. {ECO:0000250, ECO:0000269|PubMed:23791178}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePIK3CBchr3:138400809chr3:138176410ENST00000289153-1722194_2858341071.0DomainPI3K-RBD
HgenePIK3CBchr3:138400809chr3:138176410ENST00000289153-172226_1158341071.0DomainPI3K-ABD
HgenePIK3CBchr3:138400809chr3:138176410ENST00000289153-1722327_4968341071.0DomainC2 PI3K-type
HgenePIK3CBchr3:138400809chr3:138176410ENST00000289153-1722524_7018341071.0DomainPIK helical
HgenePIK3CBchr3:138400809chr3:138176410ENST00000477593-1823194_2858341071.0DomainPI3K-RBD
HgenePIK3CBchr3:138400809chr3:138176410ENST00000477593-182326_1158341071.0DomainPI3K-ABD
HgenePIK3CBchr3:138400809chr3:138176410ENST00000477593-1823327_4968341071.0DomainC2 PI3K-type
HgenePIK3CBchr3:138400809chr3:138176410ENST00000477593-1823524_7018341071.0DomainPIK helical
HgenePIK3CBchr3:138400809chr3:138176410ENST00000289153-1722410_4188341071.0MotifNote=Nuclear localization signal
HgenePIK3CBchr3:138400809chr3:138176410ENST00000477593-1823410_4188341071.0MotifNote=Nuclear localization signal
TgeneESYT3chr3:138400809chr3:138176410ENST00000389567223291_408168887.0DomainC2 1
TgeneESYT3chr3:138400809chr3:138176410ENST00000389567223426_566168887.0DomainC2 2
TgeneESYT3chr3:138400809chr3:138176410ENST00000389567223754_876168887.0DomainC2 3
TgeneESYT3chr3:138400809chr3:138176410ENST00000389567223801_808168887.0RegionRequired for phosphatidylinositol 4%2C5-bisphosphate-dependent location at the cell membrane

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePIK3CBchr3:138400809chr3:138176410ENST00000289153-1722800_10678341071.0DomainPI3K/PI4K
HgenePIK3CBchr3:138400809chr3:138176410ENST00000477593-1823800_10678341071.0DomainPI3K/PI4K
TgeneESYT3chr3:138400809chr3:138176410ENST00000389567223114_291168887.0DomainSMP-LTD
TgeneESYT3chr3:138400809chr3:138176410ENST000003895672231_29168887.0Topological domainCytoplasmic
TgeneESYT3chr3:138400809chr3:138176410ENST0000038956722372_886168887.0Topological domainCytoplasmic
TgeneESYT3chr3:138400809chr3:138176410ENST0000038956722330_50168887.0TransmembraneHelical
TgeneESYT3chr3:138400809chr3:138176410ENST0000038956722351_71168887.0TransmembraneHelical


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Fusion Gene Sequence for PIK3CB-ESYT3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>65372_65372_1_PIK3CB-ESYT3_PIK3CB_chr3_138400809_ENST00000477593_ESYT3_chr3_138176410_ENST00000289135_length(transcript)=3256nt_BP=2578nt
GGGCTGCTGACTGCGCACTTGGAATAGTAGCAGGCGGCGGCGGCGGAACGCCAGGCAGGGCCCCGTGGTTATGAATGTGCTTCAGTTTCA
TAATGCCTCCTGCTATGGCAGACATCCTTGACATCTGGGCGGTGGATTCACAGATAGCATCTGATGGCTCCATACCTGTGGATTTCCTTT
TGCCCACTGGGATTTATATCCAGTTGGAGGTACCTCGGGAAGCTACCATTTCTTATATTAAGCAGATGTTATGGAAGCAAGTTCACAATT
ACCCAATGTTCAACCTCCTTATGGATATTGACTCCTATATGTTTGCATGTGTGAATCAGACTGCTGTATATGAGGAGCTTGAAGATGAAA
CACGAAGACTCTGTGATGTCAGACCTTTTCTTCCAGTTCTCAAATTAGTGACAAGAAGTTGTGACCCAGGGGAAAAATTAGACTCAAAAA
TTGGAGTCCTTATAGGAAAAGGTCTGCATGAATTTGATTCCTTGAAGGATCCTGAAGTAAATGAATTTCGAAGAAAAATGCGCAAATTCA
GCGAGGAAAAAATCCTGTCACTTGTGGGATTGTCTTGGATGGACTGGCTAAAACAAACATATCCACCAGAGCATGAACCATCCATCCCTG
AAAACTTAGAAGATAAACTTTATGGGGGAAAGCTCATCGTAGCTGTTCATTTTGAAAACTGCCAGGACGTGTTTAGCTTTCAAGTGTCTC
CTAATATGAATCCTATCAAAGTAAATGAATTGGCAATCCAAAAACGTTTGACTATTCATGGGAAGGAAGATGAAGTTAGCCCCTATGATT
ATGTGTTGCAAGTCAGCGGGAGAGTAGAATATGTTTTTGGTGATCATCCACTAATTCAGTTCCAGTATATCCGGAACTGTGTGATGAACA
GAGCCCTGCCCCATTTTATACTTGTGGAATGCTGCAAGATCAAGAAAATGTATGAACAAGAAATGATTGCCATAGAGGCTGCCATAAATC
GAAATTCATCTAATCTTCCTCTTCCATTACCACCAAAGAAAACACGAATTATTTCTCATGTTTGGGAAAATAACAACCCTTTCCAAATTG
TCTTGGTTAAGGGAAATAAACTTAACACAGAGGAAACTGTAAAAGTTCATGTCAGGGCTGGTCTTTTTCATGGTACTGAGCTCCTGTGTA
AAACCATCGTAAGCTCAGAGGTATCAGGGAAAAATGATCATATTTGGAATGAACCACTGGAATTTGATATTAATATTTGTGACTTACCAA
GAATGGCTCGATTATGTTTTGCTGTTTATGCAGTTTTGGATAAAGTAAAAACGAAGAAATCAACGAAAACTATTAATCCCTCTAAATATC
AGACCATCAGGAAAGCTGGAAAAGTGCATTATCCTGTAGCGTGGGTAAATACGATGGTTTTTGACTTTAAAGGACAATTGAGAACTGGAG
ACATAATATTACACAGCTGGTCTTCATTTCCTGATGAACTCGAAGAAATGTTGAATCCAATGGGAACTGTTCAAACAAATCCATATACTG
AAAATGCAACAGCTTTGCATGTTAAATTTCCAGAGAATAAAAAACAACCTTATTATTACCCTCCCTTCGATAAGATTATTGAAAAGGCAG
CTGAGATTGCAAGCAGTGATAGTGCTAATGTGTCAAGTCGAGGTGGAAAAAAGTTTCTTCCTGTATTGAAAGAAATCTTGGACAGGGATC
CCTTGTCTCAACTGTGTGAAAATGAAATGGATCTTATTTGGACTTTGCGACAAGACTGCCGAGAGATTTTCCCACAATCACTGCCAAAAT
TACTGCTGTCAATCAAGTGGAATAAACTTGAGGATGTTGCTCAGCTTCAGGCGCTGCTTCAGATTTGGCCTAAACTGCCCCCCCGGGAGG
CCCTAGAGCTTCTGGATTTCAACTATCCAGACCAGTACGTTCGAGAATATGCTGTAGGCTGCCTGCGACAGATGAGTGATGAAGAACTTT
CTCAATATCTTTTACAACTGGTGCAAGTGTTAAAATATGAGCCTTTTCTTGATTGTGCCCTCTCTAGATTCCTATTAGAAAGAGCACTTG
GTAATCGGAGGATAGGGCAGTTTCTATTTTGGCATCTTAGGTCAGAAGTGCACATTCCTGCTGTCTCAGTACAATTTGGTGTCATCCTTG
AAGCATACTGCCGGGGAAGTGTGGGGCACATGAAAGTGCTTTCTAAGCAGGTTGAAGCACTCAATAAGTTAAAAACTTTAAATAGTTTAA
TCAAACTGAATGCCGTGAAGTTAAACAGAGCCAAAGGGAAGGAGGCCATGCATACCTGTTTAAAACAGAGTGCTTACCGGGAAGCCCTCT
CTGACCTGCAGTCACCCCTGAACCCATGTGTTATCCTCTCAGAACTCTATGTTGAAAAGTGCAAATACATGGATTCCAAAATGAAGCCTT
TGTGGCTGGTATACAATAACAAGGTATTTGGTGAGGATTCAGTTGGAGTGATTTTTAAAAATGGTGATGATTTACGACAGGATATGTTGA
CACTCCAAATGTTGCGCTTGATGGATTTACTCTGGAAAGAAGCTGGTTTGGATCTTCGTGTCCCAGGGTCAACGGTGTCAAGGCACACAC
TAATACGTGCAACCGAAGACGTGTGACTGTGGACCTGCAGATCTGCTACATCGGGGACTGTGAGATCAGTGTGGAGCTGCAGAAGATTCA
GGCTGGTGTGAACGGGATCCAGTTGCAGGGCACCCTGCGGGTCATCCTGGAGCCCCTCCTAGTGGACAAGCCCTTTGTGGGAGCCGTGAC
TGTGTTCTTCCTTCAGAAGCCGCACCTACAGATCAACTGGACTGGCCTGACCAACCTGCTGGATGCGCCGGGAATCAATGATGTGTCAGA
CAGCTTACTGGAGGACCTCATTGCCACCCACCTGGTGCTGCCCAACCGTGTGACTGTGCCTGTGAAGAAGGGGCTGGATCTGACCAACCT
GCGCTTCCCTCTGCCCTGTGTGAGTACCCAGTACTAGCCACAGACCAGCCTGCTGGGAGGCAGCGCAAATATCCTCTCAGCCTTCACATG
TGGTGCATTGGCTTTATTTCACACTAATGCTTGACAGTCCCAGAAAAATGGTACAAACACCATCGCCCACGTCATAATTACTAAAGACAT
TTTGTCCTTGGGGTGTATCCCACTTGGGAGGTAGTGTCAAATTTACTGCATTCTAAACTTACTTGGAATATTTCCTCTGTTTGTGACAAC

>65372_65372_1_PIK3CB-ESYT3_PIK3CB_chr3_138400809_ENST00000477593_ESYT3_chr3_138176410_ENST00000289135_length(amino acids)=853AA_BP=835
MCFSFIMPPAMADILDIWAVDSQIASDGSIPVDFLLPTGIYIQLEVPREATISYIKQMLWKQVHNYPMFNLLMDIDSYMFACVNQTAVYE
ELEDETRRLCDVRPFLPVLKLVTRSCDPGEKLDSKIGVLIGKGLHEFDSLKDPEVNEFRRKMRKFSEEKILSLVGLSWMDWLKQTYPPEH
EPSIPENLEDKLYGGKLIVAVHFENCQDVFSFQVSPNMNPIKVNELAIQKRLTIHGKEDEVSPYDYVLQVSGRVEYVFGDHPLIQFQYIR
NCVMNRALPHFILVECCKIKKMYEQEMIAIEAAINRNSSNLPLPLPPKKTRIISHVWENNNPFQIVLVKGNKLNTEETVKVHVRAGLFHG
TELLCKTIVSSEVSGKNDHIWNEPLEFDINICDLPRMARLCFAVYAVLDKVKTKKSTKTINPSKYQTIRKAGKVHYPVAWVNTMVFDFKG
QLRTGDIILHSWSSFPDELEEMLNPMGTVQTNPYTENATALHVKFPENKKQPYYYPPFDKIIEKAAEIASSDSANVSSRGGKKFLPVLKE
ILDRDPLSQLCENEMDLIWTLRQDCREIFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPKLPPREALELLDFNYPDQYVREYAVGCLRQM
SDEELSQYLLQLVQVLKYEPFLDCALSRFLLERALGNRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKVLSKQVEALNKLK
TLNSLIKLNAVKLNRAKGKEAMHTCLKQSAYREALSDLQSPLNPCVILSELYVEKCKYMDSKMKPLWLVYNNKVFGEDSVGVIFKNGDDL

--------------------------------------------------------------
>65372_65372_2_PIK3CB-ESYT3_PIK3CB_chr3_138400809_ENST00000477593_ESYT3_chr3_138176410_ENST00000389567_length(transcript)=6295nt_BP=2578nt
GGGCTGCTGACTGCGCACTTGGAATAGTAGCAGGCGGCGGCGGCGGAACGCCAGGCAGGGCCCCGTGGTTATGAATGTGCTTCAGTTTCA
TAATGCCTCCTGCTATGGCAGACATCCTTGACATCTGGGCGGTGGATTCACAGATAGCATCTGATGGCTCCATACCTGTGGATTTCCTTT
TGCCCACTGGGATTTATATCCAGTTGGAGGTACCTCGGGAAGCTACCATTTCTTATATTAAGCAGATGTTATGGAAGCAAGTTCACAATT
ACCCAATGTTCAACCTCCTTATGGATATTGACTCCTATATGTTTGCATGTGTGAATCAGACTGCTGTATATGAGGAGCTTGAAGATGAAA
CACGAAGACTCTGTGATGTCAGACCTTTTCTTCCAGTTCTCAAATTAGTGACAAGAAGTTGTGACCCAGGGGAAAAATTAGACTCAAAAA
TTGGAGTCCTTATAGGAAAAGGTCTGCATGAATTTGATTCCTTGAAGGATCCTGAAGTAAATGAATTTCGAAGAAAAATGCGCAAATTCA
GCGAGGAAAAAATCCTGTCACTTGTGGGATTGTCTTGGATGGACTGGCTAAAACAAACATATCCACCAGAGCATGAACCATCCATCCCTG
AAAACTTAGAAGATAAACTTTATGGGGGAAAGCTCATCGTAGCTGTTCATTTTGAAAACTGCCAGGACGTGTTTAGCTTTCAAGTGTCTC
CTAATATGAATCCTATCAAAGTAAATGAATTGGCAATCCAAAAACGTTTGACTATTCATGGGAAGGAAGATGAAGTTAGCCCCTATGATT
ATGTGTTGCAAGTCAGCGGGAGAGTAGAATATGTTTTTGGTGATCATCCACTAATTCAGTTCCAGTATATCCGGAACTGTGTGATGAACA
GAGCCCTGCCCCATTTTATACTTGTGGAATGCTGCAAGATCAAGAAAATGTATGAACAAGAAATGATTGCCATAGAGGCTGCCATAAATC
GAAATTCATCTAATCTTCCTCTTCCATTACCACCAAAGAAAACACGAATTATTTCTCATGTTTGGGAAAATAACAACCCTTTCCAAATTG
TCTTGGTTAAGGGAAATAAACTTAACACAGAGGAAACTGTAAAAGTTCATGTCAGGGCTGGTCTTTTTCATGGTACTGAGCTCCTGTGTA
AAACCATCGTAAGCTCAGAGGTATCAGGGAAAAATGATCATATTTGGAATGAACCACTGGAATTTGATATTAATATTTGTGACTTACCAA
GAATGGCTCGATTATGTTTTGCTGTTTATGCAGTTTTGGATAAAGTAAAAACGAAGAAATCAACGAAAACTATTAATCCCTCTAAATATC
AGACCATCAGGAAAGCTGGAAAAGTGCATTATCCTGTAGCGTGGGTAAATACGATGGTTTTTGACTTTAAAGGACAATTGAGAACTGGAG
ACATAATATTACACAGCTGGTCTTCATTTCCTGATGAACTCGAAGAAATGTTGAATCCAATGGGAACTGTTCAAACAAATCCATATACTG
AAAATGCAACAGCTTTGCATGTTAAATTTCCAGAGAATAAAAAACAACCTTATTATTACCCTCCCTTCGATAAGATTATTGAAAAGGCAG
CTGAGATTGCAAGCAGTGATAGTGCTAATGTGTCAAGTCGAGGTGGAAAAAAGTTTCTTCCTGTATTGAAAGAAATCTTGGACAGGGATC
CCTTGTCTCAACTGTGTGAAAATGAAATGGATCTTATTTGGACTTTGCGACAAGACTGCCGAGAGATTTTCCCACAATCACTGCCAAAAT
TACTGCTGTCAATCAAGTGGAATAAACTTGAGGATGTTGCTCAGCTTCAGGCGCTGCTTCAGATTTGGCCTAAACTGCCCCCCCGGGAGG
CCCTAGAGCTTCTGGATTTCAACTATCCAGACCAGTACGTTCGAGAATATGCTGTAGGCTGCCTGCGACAGATGAGTGATGAAGAACTTT
CTCAATATCTTTTACAACTGGTGCAAGTGTTAAAATATGAGCCTTTTCTTGATTGTGCCCTCTCTAGATTCCTATTAGAAAGAGCACTTG
GTAATCGGAGGATAGGGCAGTTTCTATTTTGGCATCTTAGGTCAGAAGTGCACATTCCTGCTGTCTCAGTACAATTTGGTGTCATCCTTG
AAGCATACTGCCGGGGAAGTGTGGGGCACATGAAAGTGCTTTCTAAGCAGGTTGAAGCACTCAATAAGTTAAAAACTTTAAATAGTTTAA
TCAAACTGAATGCCGTGAAGTTAAACAGAGCCAAAGGGAAGGAGGCCATGCATACCTGTTTAAAACAGAGTGCTTACCGGGAAGCCCTCT
CTGACCTGCAGTCACCCCTGAACCCATGTGTTATCCTCTCAGAACTCTATGTTGAAAAGTGCAAATACATGGATTCCAAAATGAAGCCTT
TGTGGCTGGTATACAATAACAAGGTATTTGGTGAGGATTCAGTTGGAGTGATTTTTAAAAATGGTGATGATTTACGACAGGATATGTTGA
CACTCCAAATGTTGCGCTTGATGGATTTACTCTGGAAAGAAGCTGGTTTGGATCTTCGTGTCCCAGGGTCAACGGTGTCAAGGCACACAC
TAATACGTGCAACCGAAGACGTGTGACTGTGGACCTGCAGATCTGCTACATCGGGGACTGTGAGATCAGTGTGGAGCTGCAGAAGATTCA
GGCTGGTGTGAACGGGATCCAGTTGCAGGGCACCCTGCGGGTCATCCTGGAGCCCCTCCTAGTGGACAAGCCCTTTGTGGGAGCCGTGAC
TGTGTTCTTCCTTCAGAAGCCGCACCTACAGATCAACTGGACTGGCCTGACCAACCTGCTGGATGCGCCGGGAATCAATGATGTGTCAGA
CAGCTTACTGGAGGACCTCATTGCCACCCACCTGGTGCTGCCCAACCGTGTGACTGTGCCTGTGAAGAAGGGGCTGGATCTGACCAACCT
GCGCTTCCCTCTGCCCTGTGGGGTGATCAGAGTGCACTTGCTGGAGGCAGAGCAGCTGGCCCAGAAGGACAACTTTCTGGGGCTCCGAGG
CAAGTCAGATCCCTACGCCAAGGTGAGCATCGGCCTACAGCATTTCCGGAGTAGGACCATCTACAGGAACCTGAACCCCACCTGGAACGA
AGTGTTTGAGTTCATGGTGTACGAAGTCCCTGGACAGGACCTGGAGGTAGACCTGTATGATGAGGATACCGACAGGGATGACTTCCTGGG
CAGCCTGCAGATCTGCCTTGGAGATGTCATGACCAACAGAGTGGTGGATGAGTGGTTTGTCCTGAATGACACAACCAGCGGGCGGCTGCA
CCTGCGGCTGGAGTGGCTTTCATTGCTTACTGACCAAGAAGTTCTGACTGAGGACCATGGTGGCCTTTCCACTGCCATTCTCGTGGTCTT
CTTGGAGAGTGCCTGCAACTTGCCGAGAAACCCTTTTGACTACCTGAATGGTGAATATCGAGCCAAAAAACTCTCCAGGTTTGCCAGAAA
CAAGGTCAGCAAAGACCCTTCTTCCTATGTCAAACTATCTGTAGGCAAGAAGACACATACAAGTAAGACCTGTCCCCACAACAAGGACCC
TGTGTGGAGCCAGGTGTTCTCCTTCTTTGTGCACAATGTGGCCACTGAGCGGCTCCATCTGAAGGTGCTTGATGATGACCAGGAGTGTGC
TCTGGGAATGCTGGAGGTCCCCCTGTGCCAGATCCTCCCCTATGCTGACCTCACTCTTGAGCAGCGCTTTCAGCTGGACCACTCAGGCCT
GGACAGCCTCATCTCCATGAGGCTGGTGCTTCGGTTCCTGCAAGTGGAGGAACGAGAGCTGGGGAGCCCATACACAGGACCTGAAGCCCT
AAAGAAAGGCCCTCTGCTCATCAAGAAAGTGGCTACCAACCAGGGTCCCAAAGCCCAACCTCAGGAAGAAGGCCCTACAGATTTGCCATG
TCCCCCAGACCCTGCTTCTGATACTAAGGACGTATCCAGGAGTACCACAACCACCACCAGTGCTACCACCGTTGCCACTGAGCCCACATC
CCAAGAGACAGGCCCAGAGCCTAAAGGCAAGGACAGTGCCAAAAGGTTCTGTGAGCCCATCGGGGAGAAGAAGAGTCCAGCCACCATCTT
CCTGACTGTCCCAGGTCCCCACTCTCCAGGGCCCATCAAGTCACCCAGACCCATGAAATGCCCTGCCTCCCCATTCGCATGGCCGCCCAA
GAGGCTGGCTCCCAGCATGTCCTCGCTCAACTCCTTGGCCTCTTCTTGCTTTGACCTGGCAGATATCAGCCTCAACATTGAAGGTGGGGA
CCTCAGGCGACGGCAGCTGGGTGAGATTCAGCTCACAGTGCGCTATGTGTGTCTGCGGCGCTGCCTCAGCGTGCTAATCAATGGCTGCAG
AAACCTAACACCATGTACCAGCAGTGGAGCTGATCCCTACGTCCGTGTCTACTTGTTGCCAGAAAGGAAGTGGGCATGTCGTAAGAAGAC
TTCAGTGAAGCGGAAGACCTTGGAACCCCTGTTTGATGAGACATTTGAATTTTTTGTTCCCATGGAAGAAGTAAAGAAGAGGTCACTAGA
TGTTGCAGTGAAAAATAGTAGGCCACTTGGCTCACACAGAAGAAAGGAGTTAGGAAAAGTACTGATTGACTTATCAAAAGAAGATCTGAT
TAAGGGCTTTTCACAATGGTATGAGCTGACTCCAAATGGACAGCCCAGAAGCTGATGATGAGAATTCTTATCACTCACCTTTATATTAAA
ATGTATATATATGTATATATTTTTTCCTTTGGATCACTTACATCCAATATATGTATATTTTGTCATTTAAATCAGAACAACCACTTGAAA
TTATATACATACAATTCTTGTGTGGAATTTAACTCCATGACTGAATAGCATAAGGAAGAGGTTATTTAAAAGCAAGAACTACTTTTTTTG
GTTGGATTTTTTTGTTCAAGTCCAGAAAGAAATGTTATATTTGTGCCTACTAAATTATCCAAACCTCAGTGTTTATATACTTAAACAAGT
GCCACTTTTTAGTAGGTAATTATATACCATCTGATTTAGGACTTACCTGAATGTATGTACCAGAAAGTGTCCTGCCTCTGGCATAGGGGC
TGGGGGAGGTCTGTTTCTGGAGCCACTACCAGCATTCCTGGGCAGTGACTGGCCAAAGGGAAGTCACTTTTTTATGGAAATAGAAAGTGA
CCCAACTCAAAACTGCCAAGAGCTAACACTGCCAAAGCCCTTCTGGCTGCCACCTGTGGTACTTGTATGCCTGGATATTTGTTCTTTTAT
TTGACCTGGAGCTAAAAATGTATTTCCCTACTGGCAAAAATGTTATACTGATATACTTAAATACCTTGAGTTAAATACTCTTGTGTAGTC
TAAGGGCCAAACTCCAGCGTGTAGCATTATTTCCATAGGAAAATGCAAACCAAGTTCCAAGCCCAGGTCTATGTCTGACTCTCATAGCAA
AGCACTGGAGACTGCTGAAGAGTGTCACCATCAGAGAAAAGGAAGCTTTCAGATAAGTTTAGGCTATTCAACTTTTCTAAAGAGATGGTT
GGTTCACCTAAATAACATGTTAAAAGCAAAGTATTAAATTATATGCTTAAACAAGCGCCTCTTTTACATTTCAGACTTTACAAGACCAAA
TATACTTCTCATCCCCTCCAACATTCCTGGACCTCCTCTTCTCTCTTACCAACACCAACACTACCTGCCGTCAGTTTTCTGTCTCTGCCT
CTGCCTTCACTGCCACTTTTCTGAAGCAGGGCAACATTCGAGAACAAAGTTTTGTCATGTTACTCTTATTCCAGTTTCCTGCCATCTGAT
TCACATGCAGATGTTCTATTCCAGAGTAGTCCAAATACTATGCTCTGCTGACTCAAGTCATGTCTCAAACCTATTTCCTCTATTAAGTAA
GTCAGTCAATCCATAGTGAAATGGACTCTTCCTACCGCCTGTAGCATTTACTGTTGATACTGAGTATTTTCCATTTTAATAGTTCCCAGC
CTTTATAACACTAAGTTTTAAGAAATGTTGATTAGGCATCTGCTAAGGTTACATGCTAAGCAGCTACTTATATTGTATTTGGTATTTAAT
TTTGTTTATTCTCCAGTTGAACAGTAGGGAACAATTCAAGCTACTTGAATTGTTTTTCACCCTCACCATCCAAGACCGTGTTAAGTACAT

>65372_65372_2_PIK3CB-ESYT3_PIK3CB_chr3_138400809_ENST00000477593_ESYT3_chr3_138176410_ENST00000389567_length(amino acids)=853AA_BP=835
MCFSFIMPPAMADILDIWAVDSQIASDGSIPVDFLLPTGIYIQLEVPREATISYIKQMLWKQVHNYPMFNLLMDIDSYMFACVNQTAVYE
ELEDETRRLCDVRPFLPVLKLVTRSCDPGEKLDSKIGVLIGKGLHEFDSLKDPEVNEFRRKMRKFSEEKILSLVGLSWMDWLKQTYPPEH
EPSIPENLEDKLYGGKLIVAVHFENCQDVFSFQVSPNMNPIKVNELAIQKRLTIHGKEDEVSPYDYVLQVSGRVEYVFGDHPLIQFQYIR
NCVMNRALPHFILVECCKIKKMYEQEMIAIEAAINRNSSNLPLPLPPKKTRIISHVWENNNPFQIVLVKGNKLNTEETVKVHVRAGLFHG
TELLCKTIVSSEVSGKNDHIWNEPLEFDINICDLPRMARLCFAVYAVLDKVKTKKSTKTINPSKYQTIRKAGKVHYPVAWVNTMVFDFKG
QLRTGDIILHSWSSFPDELEEMLNPMGTVQTNPYTENATALHVKFPENKKQPYYYPPFDKIIEKAAEIASSDSANVSSRGGKKFLPVLKE
ILDRDPLSQLCENEMDLIWTLRQDCREIFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPKLPPREALELLDFNYPDQYVREYAVGCLRQM
SDEELSQYLLQLVQVLKYEPFLDCALSRFLLERALGNRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKVLSKQVEALNKLK
TLNSLIKLNAVKLNRAKGKEAMHTCLKQSAYREALSDLQSPLNPCVILSELYVEKCKYMDSKMKPLWLVYNNKVFGEDSVGVIFKNGDDL

--------------------------------------------------------------
>65372_65372_3_PIK3CB-ESYT3_PIK3CB_chr3_138400809_ENST00000544716_ESYT3_chr3_138176410_ENST00000289135_length(transcript)=1783nt_BP=1105nt
CAGGAAAGCTGGAAAAGTGCATTATCCTGTAGCGTGGGTAAATACGATGGTTTTTGACTTTAAAGGACAATTGAGAACTGGAGACATAAT
ATTACACAGCTGGTCTTCATTTCCTGATTATTGAAAAGGCAGCTGAGATTGCAAGCAGTGATAGTGCTAATGTGTCAAGTCGAGGTGGAA
AAAAGTTTCTTCCTGTATTGAAAGAAATCTTGGACAGGGATCCCTTGTCTCAACTGTGTGAAAATGAAATGGATCTTATTTGGACTTTGC
GACAAGACTGCCGAGAGATTTTCCCACAATCACTGCCAAAATTACTGCTGTCAATCAAGTGGAATAAACTTGAGGATGTTGCTCAGCTTC
AGGCGCTGCTTCAGATTTGGCCTAAACTGCCCCCCCGGGAGGCCCTAGAGCTTCTGGATTTCAACTATCCAGACCAGTACGTTCGAGAAT
ATGCTGTAGGCTGCCTGCGACAGATGAGTGATGAAGAACTTTCTCAATATCTTTTACAACTGGTGCAAGTGTTAAAATATGAGCCTTTTC
TTGATTGTGCCCTCTCTAGATTCCTATTAGAAAGAGCACTTGGTAATCGGAGGATAGGGCAGTTTCTATTTTGGCATCTTAGGTCAGAAG
TGCACATTCCTGCTGTCTCAGTACAATTTGGTGTCATCCTTGAAGCATACTGCCGGGGAAGTGTGGGGCACATGAAAGTGCTTTCTAAGC
AGGTTGAAGCACTCAATAAGTTAAAAACTTTAAATAGTTTAATCAAACTGAATGCCGTGAAGTTAAACAGAGCCAAAGGGAAGGAGGCCA
TGCATACCTGTTTAAAACAGAGTGCTTACCGGGAAGCCCTCTCTGACCTGCAGTCACCCCTGAACCCATGTGTTATCCTCTCAGAACTCT
ATGTTGAAAAGTGCAAATACATGGATTCCAAAATGAAGCCTTTGTGGCTGGTATACAATAACAAGGTATTTGGTGAGGATTCAGTTGGAG
TGATTTTTAAAAATGGTGATGTTTGTTTTCCCTTAGATTTACGACAGGATATGTTGACACTCCAAATGTTGCGCTTGATGGATTTACTCT
GGAAAGAAGCTGGTTTGGATCTTCGTGTCCCAGGGTCAACGGTGTCAAGGCACACACTAATACGTGCAACCGAAGACGTGTGACTGTGGA
CCTGCAGATCTGCTACATCGGGGACTGTGAGATCAGTGTGGAGCTGCAGAAGATTCAGGCTGGTGTGAACGGGATCCAGTTGCAGGGCAC
CCTGCGGGTCATCCTGGAGCCCCTCCTAGTGGACAAGCCCTTTGTGGGAGCCGTGACTGTGTTCTTCCTTCAGAAGCCGCACCTACAGAT
CAACTGGACTGGCCTGACCAACCTGCTGGATGCGCCGGGAATCAATGATGTGTCAGACAGCTTACTGGAGGACCTCATTGCCACCCACCT
GGTGCTGCCCAACCGTGTGACTGTGCCTGTGAAGAAGGGGCTGGATCTGACCAACCTGCGCTTCCCTCTGCCCTGTGTGAGTACCCAGTA
CTAGCCACAGACCAGCCTGCTGGGAGGCAGCGCAAATATCCTCTCAGCCTTCACATGTGGTGCATTGGCTTTATTTCACACTAATGCTTG
ACAGTCCCAGAAAAATGGTACAAACACCATCGCCCACGTCATAATTACTAAAGACATTTTGTCCTTGGGGTGTATCCCACTTGGGAGGTA

>65372_65372_3_PIK3CB-ESYT3_PIK3CB_chr3_138400809_ENST00000544716_ESYT3_chr3_138176410_ENST00000289135_length(amino acids)=349AA_BP=331
MIIEKAAEIASSDSANVSSRGGKKFLPVLKEILDRDPLSQLCENEMDLIWTLRQDCREIFPQSLPKLLLSIKWNKLEDVAQLQALLQIWP
KLPPREALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFLLERALGNRRIGQFLFWHLRSEVHIPAVSV
QFGVILEAYCRGSVGHMKVLSKQVEALNKLKTLNSLIKLNAVKLNRAKGKEAMHTCLKQSAYREALSDLQSPLNPCVILSELYVEKCKYM

--------------------------------------------------------------
>65372_65372_4_PIK3CB-ESYT3_PIK3CB_chr3_138400809_ENST00000544716_ESYT3_chr3_138176410_ENST00000389567_length(transcript)=4822nt_BP=1105nt
CAGGAAAGCTGGAAAAGTGCATTATCCTGTAGCGTGGGTAAATACGATGGTTTTTGACTTTAAAGGACAATTGAGAACTGGAGACATAAT
ATTACACAGCTGGTCTTCATTTCCTGATTATTGAAAAGGCAGCTGAGATTGCAAGCAGTGATAGTGCTAATGTGTCAAGTCGAGGTGGAA
AAAAGTTTCTTCCTGTATTGAAAGAAATCTTGGACAGGGATCCCTTGTCTCAACTGTGTGAAAATGAAATGGATCTTATTTGGACTTTGC
GACAAGACTGCCGAGAGATTTTCCCACAATCACTGCCAAAATTACTGCTGTCAATCAAGTGGAATAAACTTGAGGATGTTGCTCAGCTTC
AGGCGCTGCTTCAGATTTGGCCTAAACTGCCCCCCCGGGAGGCCCTAGAGCTTCTGGATTTCAACTATCCAGACCAGTACGTTCGAGAAT
ATGCTGTAGGCTGCCTGCGACAGATGAGTGATGAAGAACTTTCTCAATATCTTTTACAACTGGTGCAAGTGTTAAAATATGAGCCTTTTC
TTGATTGTGCCCTCTCTAGATTCCTATTAGAAAGAGCACTTGGTAATCGGAGGATAGGGCAGTTTCTATTTTGGCATCTTAGGTCAGAAG
TGCACATTCCTGCTGTCTCAGTACAATTTGGTGTCATCCTTGAAGCATACTGCCGGGGAAGTGTGGGGCACATGAAAGTGCTTTCTAAGC
AGGTTGAAGCACTCAATAAGTTAAAAACTTTAAATAGTTTAATCAAACTGAATGCCGTGAAGTTAAACAGAGCCAAAGGGAAGGAGGCCA
TGCATACCTGTTTAAAACAGAGTGCTTACCGGGAAGCCCTCTCTGACCTGCAGTCACCCCTGAACCCATGTGTTATCCTCTCAGAACTCT
ATGTTGAAAAGTGCAAATACATGGATTCCAAAATGAAGCCTTTGTGGCTGGTATACAATAACAAGGTATTTGGTGAGGATTCAGTTGGAG
TGATTTTTAAAAATGGTGATGTTTGTTTTCCCTTAGATTTACGACAGGATATGTTGACACTCCAAATGTTGCGCTTGATGGATTTACTCT
GGAAAGAAGCTGGTTTGGATCTTCGTGTCCCAGGGTCAACGGTGTCAAGGCACACACTAATACGTGCAACCGAAGACGTGTGACTGTGGA
CCTGCAGATCTGCTACATCGGGGACTGTGAGATCAGTGTGGAGCTGCAGAAGATTCAGGCTGGTGTGAACGGGATCCAGTTGCAGGGCAC
CCTGCGGGTCATCCTGGAGCCCCTCCTAGTGGACAAGCCCTTTGTGGGAGCCGTGACTGTGTTCTTCCTTCAGAAGCCGCACCTACAGAT
CAACTGGACTGGCCTGACCAACCTGCTGGATGCGCCGGGAATCAATGATGTGTCAGACAGCTTACTGGAGGACCTCATTGCCACCCACCT
GGTGCTGCCCAACCGTGTGACTGTGCCTGTGAAGAAGGGGCTGGATCTGACCAACCTGCGCTTCCCTCTGCCCTGTGGGGTGATCAGAGT
GCACTTGCTGGAGGCAGAGCAGCTGGCCCAGAAGGACAACTTTCTGGGGCTCCGAGGCAAGTCAGATCCCTACGCCAAGGTGAGCATCGG
CCTACAGCATTTCCGGAGTAGGACCATCTACAGGAACCTGAACCCCACCTGGAACGAAGTGTTTGAGTTCATGGTGTACGAAGTCCCTGG
ACAGGACCTGGAGGTAGACCTGTATGATGAGGATACCGACAGGGATGACTTCCTGGGCAGCCTGCAGATCTGCCTTGGAGATGTCATGAC
CAACAGAGTGGTGGATGAGTGGTTTGTCCTGAATGACACAACCAGCGGGCGGCTGCACCTGCGGCTGGAGTGGCTTTCATTGCTTACTGA
CCAAGAAGTTCTGACTGAGGACCATGGTGGCCTTTCCACTGCCATTCTCGTGGTCTTCTTGGAGAGTGCCTGCAACTTGCCGAGAAACCC
TTTTGACTACCTGAATGGTGAATATCGAGCCAAAAAACTCTCCAGGTTTGCCAGAAACAAGGTCAGCAAAGACCCTTCTTCCTATGTCAA
ACTATCTGTAGGCAAGAAGACACATACAAGTAAGACCTGTCCCCACAACAAGGACCCTGTGTGGAGCCAGGTGTTCTCCTTCTTTGTGCA
CAATGTGGCCACTGAGCGGCTCCATCTGAAGGTGCTTGATGATGACCAGGAGTGTGCTCTGGGAATGCTGGAGGTCCCCCTGTGCCAGAT
CCTCCCCTATGCTGACCTCACTCTTGAGCAGCGCTTTCAGCTGGACCACTCAGGCCTGGACAGCCTCATCTCCATGAGGCTGGTGCTTCG
GTTCCTGCAAGTGGAGGAACGAGAGCTGGGGAGCCCATACACAGGACCTGAAGCCCTAAAGAAAGGCCCTCTGCTCATCAAGAAAGTGGC
TACCAACCAGGGTCCCAAAGCCCAACCTCAGGAAGAAGGCCCTACAGATTTGCCATGTCCCCCAGACCCTGCTTCTGATACTAAGGACGT
ATCCAGGAGTACCACAACCACCACCAGTGCTACCACCGTTGCCACTGAGCCCACATCCCAAGAGACAGGCCCAGAGCCTAAAGGCAAGGA
CAGTGCCAAAAGGTTCTGTGAGCCCATCGGGGAGAAGAAGAGTCCAGCCACCATCTTCCTGACTGTCCCAGGTCCCCACTCTCCAGGGCC
CATCAAGTCACCCAGACCCATGAAATGCCCTGCCTCCCCATTCGCATGGCCGCCCAAGAGGCTGGCTCCCAGCATGTCCTCGCTCAACTC
CTTGGCCTCTTCTTGCTTTGACCTGGCAGATATCAGCCTCAACATTGAAGGTGGGGACCTCAGGCGACGGCAGCTGGGTGAGATTCAGCT
CACAGTGCGCTATGTGTGTCTGCGGCGCTGCCTCAGCGTGCTAATCAATGGCTGCAGAAACCTAACACCATGTACCAGCAGTGGAGCTGA
TCCCTACGTCCGTGTCTACTTGTTGCCAGAAAGGAAGTGGGCATGTCGTAAGAAGACTTCAGTGAAGCGGAAGACCTTGGAACCCCTGTT
TGATGAGACATTTGAATTTTTTGTTCCCATGGAAGAAGTAAAGAAGAGGTCACTAGATGTTGCAGTGAAAAATAGTAGGCCACTTGGCTC
ACACAGAAGAAAGGAGTTAGGAAAAGTACTGATTGACTTATCAAAAGAAGATCTGATTAAGGGCTTTTCACAATGGTATGAGCTGACTCC
AAATGGACAGCCCAGAAGCTGATGATGAGAATTCTTATCACTCACCTTTATATTAAAATGTATATATATGTATATATTTTTTCCTTTGGA
TCACTTACATCCAATATATGTATATTTTGTCATTTAAATCAGAACAACCACTTGAAATTATATACATACAATTCTTGTGTGGAATTTAAC
TCCATGACTGAATAGCATAAGGAAGAGGTTATTTAAAAGCAAGAACTACTTTTTTTGGTTGGATTTTTTTGTTCAAGTCCAGAAAGAAAT
GTTATATTTGTGCCTACTAAATTATCCAAACCTCAGTGTTTATATACTTAAACAAGTGCCACTTTTTAGTAGGTAATTATATACCATCTG
ATTTAGGACTTACCTGAATGTATGTACCAGAAAGTGTCCTGCCTCTGGCATAGGGGCTGGGGGAGGTCTGTTTCTGGAGCCACTACCAGC
ATTCCTGGGCAGTGACTGGCCAAAGGGAAGTCACTTTTTTATGGAAATAGAAAGTGACCCAACTCAAAACTGCCAAGAGCTAACACTGCC
AAAGCCCTTCTGGCTGCCACCTGTGGTACTTGTATGCCTGGATATTTGTTCTTTTATTTGACCTGGAGCTAAAAATGTATTTCCCTACTG
GCAAAAATGTTATACTGATATACTTAAATACCTTGAGTTAAATACTCTTGTGTAGTCTAAGGGCCAAACTCCAGCGTGTAGCATTATTTC
CATAGGAAAATGCAAACCAAGTTCCAAGCCCAGGTCTATGTCTGACTCTCATAGCAAAGCACTGGAGACTGCTGAAGAGTGTCACCATCA
GAGAAAAGGAAGCTTTCAGATAAGTTTAGGCTATTCAACTTTTCTAAAGAGATGGTTGGTTCACCTAAATAACATGTTAAAAGCAAAGTA
TTAAATTATATGCTTAAACAAGCGCCTCTTTTACATTTCAGACTTTACAAGACCAAATATACTTCTCATCCCCTCCAACATTCCTGGACC
TCCTCTTCTCTCTTACCAACACCAACACTACCTGCCGTCAGTTTTCTGTCTCTGCCTCTGCCTTCACTGCCACTTTTCTGAAGCAGGGCA
ACATTCGAGAACAAAGTTTTGTCATGTTACTCTTATTCCAGTTTCCTGCCATCTGATTCACATGCAGATGTTCTATTCCAGAGTAGTCCA
AATACTATGCTCTGCTGACTCAAGTCATGTCTCAAACCTATTTCCTCTATTAAGTAAGTCAGTCAATCCATAGTGAAATGGACTCTTCCT
ACCGCCTGTAGCATTTACTGTTGATACTGAGTATTTTCCATTTTAATAGTTCCCAGCCTTTATAACACTAAGTTTTAAGAAATGTTGATT
AGGCATCTGCTAAGGTTACATGCTAAGCAGCTACTTATATTGTATTTGGTATTTAATTTTGTTTATTCTCCAGTTGAACAGTAGGGAACA
ATTCAAGCTACTTGAATTGTTTTTCACCCTCACCATCCAAGACCGTGTTAAGTACATAGAAGATGCATGGTGAAATTCGTTTCTGCTGAG

>65372_65372_4_PIK3CB-ESYT3_PIK3CB_chr3_138400809_ENST00000544716_ESYT3_chr3_138176410_ENST00000389567_length(amino acids)=749AA_BP=31
MFSLRFTTGYVDTPNVALDGFTLERSWFGSSCPRVNGVKAHTNTCNRRRVTVDLQICYIGDCEISVELQKIQAGVNGIQLQGTLRVILEP
LLVDKPFVGAVTVFFLQKPHLQINWTGLTNLLDAPGINDVSDSLLEDLIATHLVLPNRVTVPVKKGLDLTNLRFPLPCGVIRVHLLEAEQ
LAQKDNFLGLRGKSDPYAKVSIGLQHFRSRTIYRNLNPTWNEVFEFMVYEVPGQDLEVDLYDEDTDRDDFLGSLQICLGDVMTNRVVDEW
FVLNDTTSGRLHLRLEWLSLLTDQEVLTEDHGGLSTAILVVFLESACNLPRNPFDYLNGEYRAKKLSRFARNKVSKDPSSYVKLSVGKKT
HTSKTCPHNKDPVWSQVFSFFVHNVATERLHLKVLDDDQECALGMLEVPLCQILPYADLTLEQRFQLDHSGLDSLISMRLVLRFLQVEER
ELGSPYTGPEALKKGPLLIKKVATNQGPKAQPQEEGPTDLPCPPDPASDTKDVSRSTTTTTSATTVATEPTSQETGPEPKGKDSAKRFCE
PIGEKKSPATIFLTVPGPHSPGPIKSPRPMKCPASPFAWPPKRLAPSMSSLNSLASSCFDLADISLNIEGGDLRRRQLGEIQLTVRYVCL
RRCLSVLINGCRNLTPCTSSGADPYVRVYLLPERKWACRKKTSVKRKTLEPLFDETFEFFVPMEEVKKRSLDVAVKNSRPLGSHRRKELG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PIK3CB-ESYT3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PIK3CB-ESYT3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PIK3CB-ESYT3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource