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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PIK3R3-LRRC41 (FusionGDB2 ID:65400)

Fusion Gene Summary for PIK3R3-LRRC41

check button Fusion gene summary
Fusion gene informationFusion gene name: PIK3R3-LRRC41
Fusion gene ID: 65400
HgeneTgene
Gene symbol

PIK3R3

LRRC41

Gene ID

8503

10489

Gene namephosphoinositide-3-kinase regulatory subunit 3leucine rich repeat containing 41
Synonymsp55|p55-GAMMA|p55PIKMUF1|PP7759
Cytomap

1p34.1

1p34.1-p33

Type of geneprotein-codingprotein-coding
Descriptionphosphatidylinositol 3-kinase regulatory subunit gammaPI3-kinase regulatory subunit gammaPI3-kinase subunit p55-gammaPI3K regulatory subunit gammaphosphatidylinositol 3-kinase 55 kDa regulatory subunit gammaphosphatidylinositol 3-kinase, regulatory sleucine-rich repeat-containing protein 41MUF1 protein (MUF1)elongin BC-interacting leucine-rich repeat proteinprotein Muf1
Modification date2020032720200313
UniProtAcc.

Q15345

Ensembl transtripts involved in fusion geneENST00000262741, ENST00000340332, 
ENST00000354242, ENST00000372006, 
ENST00000420542, ENST00000423209, 
ENST00000540385, ENST00000488808, 
ENST00000472710, ENST00000343304, 
Fusion gene scores* DoF score9 X 9 X 7=5677 X 7 X 6=294
# samples 1110
** MAII scorelog2(11/567*10)=-2.36584521141757
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/294*10)=-1.55581615506164
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PIK3R3 [Title/Abstract] AND LRRC41 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPIK3R3(46527601)-LRRC41(46747057), # samples:3
PIK3R3(46543187)-LRRC41(46752171), # samples:3
Anticipated loss of major functional domain due to fusion event.PIK3R3-LRRC41 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
PIK3R3-LRRC41 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
PIK3R3-LRRC41 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PIK3R3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LRRC41 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-C8-A135-01APIK3R3chr1

46546314

-LRRC41chr1

46733349

-
ChimerDB4BRCATCGA-OL-A5D7-01APIK3R3chr1

46527601

-LRRC41chr1

46747057

-
ChimerDB4UCSTCGA-N9-A4Q8-01APIK3R3chr1

46543187

-LRRC41chr1

46752171

-
ChimerDB4UCSTCGA-N9-A4Q8PIK3R3chr1

46543187

-LRRC41chr1

46752171

-


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Fusion Gene ORF analysis for PIK3R3-LRRC41

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000262741ENST00000472710PIK3R3chr1

46527601

-LRRC41chr1

46747057

-
5CDS-5UTRENST00000262741ENST00000472710PIK3R3chr1

46543187

-LRRC41chr1

46752171

-
5CDS-5UTRENST00000340332ENST00000472710PIK3R3chr1

46527601

-LRRC41chr1

46747057

-
5CDS-5UTRENST00000340332ENST00000472710PIK3R3chr1

46543187

-LRRC41chr1

46752171

-
5CDS-5UTRENST00000354242ENST00000472710PIK3R3chr1

46527601

-LRRC41chr1

46747057

-
5CDS-5UTRENST00000354242ENST00000472710PIK3R3chr1

46543187

-LRRC41chr1

46752171

-
5CDS-5UTRENST00000372006ENST00000472710PIK3R3chr1

46527601

-LRRC41chr1

46747057

-
5CDS-5UTRENST00000372006ENST00000472710PIK3R3chr1

46543187

-LRRC41chr1

46752171

-
5CDS-5UTRENST00000420542ENST00000472710PIK3R3chr1

46527601

-LRRC41chr1

46747057

-
5CDS-5UTRENST00000420542ENST00000472710PIK3R3chr1

46543187

-LRRC41chr1

46752171

-
5CDS-5UTRENST00000423209ENST00000472710PIK3R3chr1

46527601

-LRRC41chr1

46747057

-
5CDS-5UTRENST00000423209ENST00000472710PIK3R3chr1

46543187

-LRRC41chr1

46752171

-
5CDS-5UTRENST00000540385ENST00000472710PIK3R3chr1

46527601

-LRRC41chr1

46747057

-
5CDS-5UTRENST00000540385ENST00000472710PIK3R3chr1

46543187

-LRRC41chr1

46752171

-
5CDS-intronENST00000262741ENST00000343304PIK3R3chr1

46546314

-LRRC41chr1

46733349

-
5CDS-intronENST00000262741ENST00000472710PIK3R3chr1

46546314

-LRRC41chr1

46733349

-
5CDS-intronENST00000354242ENST00000343304PIK3R3chr1

46546314

-LRRC41chr1

46733349

-
5CDS-intronENST00000354242ENST00000472710PIK3R3chr1

46546314

-LRRC41chr1

46733349

-
5CDS-intronENST00000372006ENST00000343304PIK3R3chr1

46546314

-LRRC41chr1

46733349

-
5CDS-intronENST00000372006ENST00000472710PIK3R3chr1

46546314

-LRRC41chr1

46733349

-
5CDS-intronENST00000420542ENST00000343304PIK3R3chr1

46546314

-LRRC41chr1

46733349

-
5CDS-intronENST00000420542ENST00000472710PIK3R3chr1

46546314

-LRRC41chr1

46733349

-
5CDS-intronENST00000423209ENST00000343304PIK3R3chr1

46546314

-LRRC41chr1

46733349

-
5CDS-intronENST00000423209ENST00000472710PIK3R3chr1

46546314

-LRRC41chr1

46733349

-
5CDS-intronENST00000540385ENST00000343304PIK3R3chr1

46546314

-LRRC41chr1

46733349

-
5CDS-intronENST00000540385ENST00000472710PIK3R3chr1

46546314

-LRRC41chr1

46733349

-
Frame-shiftENST00000262741ENST00000343304PIK3R3chr1

46527601

-LRRC41chr1

46747057

-
Frame-shiftENST00000262741ENST00000343304PIK3R3chr1

46543187

-LRRC41chr1

46752171

-
Frame-shiftENST00000340332ENST00000343304PIK3R3chr1

46527601

-LRRC41chr1

46747057

-
Frame-shiftENST00000354242ENST00000343304PIK3R3chr1

46527601

-LRRC41chr1

46747057

-
Frame-shiftENST00000372006ENST00000343304PIK3R3chr1

46543187

-LRRC41chr1

46752171

-
Frame-shiftENST00000420542ENST00000343304PIK3R3chr1

46527601

-LRRC41chr1

46747057

-
Frame-shiftENST00000423209ENST00000343304PIK3R3chr1

46527601

-LRRC41chr1

46747057

-
Frame-shiftENST00000423209ENST00000343304PIK3R3chr1

46543187

-LRRC41chr1

46752171

-
Frame-shiftENST00000540385ENST00000343304PIK3R3chr1

46527601

-LRRC41chr1

46747057

-
Frame-shiftENST00000540385ENST00000343304PIK3R3chr1

46543187

-LRRC41chr1

46752171

-
In-frameENST00000340332ENST00000343304PIK3R3chr1

46543187

-LRRC41chr1

46752171

-
In-frameENST00000354242ENST00000343304PIK3R3chr1

46543187

-LRRC41chr1

46752171

-
In-frameENST00000372006ENST00000343304PIK3R3chr1

46527601

-LRRC41chr1

46747057

-
In-frameENST00000420542ENST00000343304PIK3R3chr1

46543187

-LRRC41chr1

46752171

-
intron-3CDSENST00000488808ENST00000343304PIK3R3chr1

46527601

-LRRC41chr1

46747057

-
intron-3CDSENST00000488808ENST00000343304PIK3R3chr1

46543187

-LRRC41chr1

46752171

-
intron-5UTRENST00000488808ENST00000472710PIK3R3chr1

46527601

-LRRC41chr1

46747057

-
intron-5UTRENST00000488808ENST00000472710PIK3R3chr1

46543187

-LRRC41chr1

46752171

-
intron-intronENST00000340332ENST00000343304PIK3R3chr1

46546314

-LRRC41chr1

46733349

-
intron-intronENST00000340332ENST00000472710PIK3R3chr1

46546314

-LRRC41chr1

46733349

-
intron-intronENST00000488808ENST00000343304PIK3R3chr1

46546314

-LRRC41chr1

46733349

-
intron-intronENST00000488808ENST00000472710PIK3R3chr1

46546314

-LRRC41chr1

46733349

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000372006PIK3R3chr146527601-ENST00000343304LRRC41chr146747057-22738647581807349
ENST00000340332PIK3R3chr146543187-ENST00000343304LRRC41chr146752171-30104634902544684
ENST00000420542PIK3R3chr146543187-ENST00000343304LRRC41chr146752171-31185715982652684
ENST00000354242PIK3R3chr146543187-ENST00000343304LRRC41chr146752171-31185715982652684

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000372006ENST00000343304PIK3R3chr146527601-LRRC41chr146747057-0.0099467160.99005336
ENST00000340332ENST00000343304PIK3R3chr146543187-LRRC41chr146752171-0.034179790.9658202
ENST00000420542ENST00000343304PIK3R3chr146543187-LRRC41chr146752171-0.0343241320.9656759
ENST00000354242ENST00000343304PIK3R3chr146543187-LRRC41chr146752171-0.0343241320.9656759

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Fusion Genomic Features for PIK3R3-LRRC41


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PIK3R3-LRRC41


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:46527601/chr1:46747057)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.LRRC41

Q15345

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000269|PubMed:15601820}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePIK3R3chr1:46527601chr1:46747057ENST00000262741-61034_44254462.0Compositional biasNote=Pro-rich
HgenePIK3R3chr1:46527601chr1:46747057ENST00000354242-71034_44254403.0Compositional biasNote=Pro-rich
HgenePIK3R3chr1:46527601chr1:46747057ENST00000372006-71134_44254462.0Compositional biasNote=Pro-rich
HgenePIK3R3chr1:46527601chr1:46747057ENST00000420542-71134_44254462.0Compositional biasNote=Pro-rich
HgenePIK3R3chr1:46527601chr1:46747057ENST00000423209-6934_44254403.0Compositional biasNote=Pro-rich
HgenePIK3R3chr1:46543187chr1:46752171ENST00000262741-31034_44104462.0Compositional biasNote=Pro-rich
HgenePIK3R3chr1:46543187chr1:46752171ENST00000354242-41034_44104403.0Compositional biasNote=Pro-rich
HgenePIK3R3chr1:46543187chr1:46752171ENST00000372006-41134_44104462.0Compositional biasNote=Pro-rich
HgenePIK3R3chr1:46543187chr1:46752171ENST00000420542-41134_44104462.0Compositional biasNote=Pro-rich
HgenePIK3R3chr1:46543187chr1:46752171ENST00000423209-3934_44104403.0Compositional biasNote=Pro-rich
HgenePIK3R3chr1:46527601chr1:46747057ENST00000262741-61065_160254462.0DomainSH2 1
HgenePIK3R3chr1:46527601chr1:46747057ENST00000354242-71065_160254403.0DomainSH2 1
HgenePIK3R3chr1:46527601chr1:46747057ENST00000372006-71165_160254462.0DomainSH2 1
HgenePIK3R3chr1:46527601chr1:46747057ENST00000420542-71165_160254462.0DomainSH2 1
HgenePIK3R3chr1:46527601chr1:46747057ENST00000423209-6965_160254403.0DomainSH2 1
TgeneLRRC41chr1:46527601chr1:46747057ENST00000343304310518_530498813.0RepeatNote=LRR 2
TgeneLRRC41chr1:46527601chr1:46747057ENST00000343304310531_555498813.0RepeatNote=LRR 3
TgeneLRRC41chr1:46527601chr1:46747057ENST00000343304310613_635498813.0RepeatNote=LRR 4
TgeneLRRC41chr1:46527601chr1:46747057ENST00000343304310636_659498813.0RepeatNote=LRR 5
TgeneLRRC41chr1:46527601chr1:46747057ENST00000343304310701_728498813.0RepeatNote=LRR 6
TgeneLRRC41chr1:46527601chr1:46747057ENST00000343304310731_752498813.0RepeatNote=LRR 7
TgeneLRRC41chr1:46543187chr1:46752171ENST00000343304210487_507119813.0RepeatNote=LRR 1
TgeneLRRC41chr1:46543187chr1:46752171ENST00000343304210518_530119813.0RepeatNote=LRR 2
TgeneLRRC41chr1:46543187chr1:46752171ENST00000343304210531_555119813.0RepeatNote=LRR 3
TgeneLRRC41chr1:46543187chr1:46752171ENST00000343304210613_635119813.0RepeatNote=LRR 4
TgeneLRRC41chr1:46543187chr1:46752171ENST00000343304210636_659119813.0RepeatNote=LRR 5
TgeneLRRC41chr1:46543187chr1:46752171ENST00000343304210701_728119813.0RepeatNote=LRR 6
TgeneLRRC41chr1:46543187chr1:46752171ENST00000343304210731_752119813.0RepeatNote=LRR 7

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePIK3R3chr1:46527601chr1:46747057ENST00000262741-610358_452254462.0DomainSH2 2
HgenePIK3R3chr1:46527601chr1:46747057ENST00000354242-710358_452254403.0DomainSH2 2
HgenePIK3R3chr1:46527601chr1:46747057ENST00000372006-711358_452254462.0DomainSH2 2
HgenePIK3R3chr1:46527601chr1:46747057ENST00000420542-711358_452254462.0DomainSH2 2
HgenePIK3R3chr1:46527601chr1:46747057ENST00000423209-69358_452254403.0DomainSH2 2
HgenePIK3R3chr1:46543187chr1:46752171ENST00000262741-310358_452104462.0DomainSH2 2
HgenePIK3R3chr1:46543187chr1:46752171ENST00000262741-31065_160104462.0DomainSH2 1
HgenePIK3R3chr1:46543187chr1:46752171ENST00000354242-410358_452104403.0DomainSH2 2
HgenePIK3R3chr1:46543187chr1:46752171ENST00000354242-41065_160104403.0DomainSH2 1
HgenePIK3R3chr1:46543187chr1:46752171ENST00000372006-411358_452104462.0DomainSH2 2
HgenePIK3R3chr1:46543187chr1:46752171ENST00000372006-41165_160104462.0DomainSH2 1
HgenePIK3R3chr1:46543187chr1:46752171ENST00000420542-411358_452104462.0DomainSH2 2
HgenePIK3R3chr1:46543187chr1:46752171ENST00000420542-41165_160104462.0DomainSH2 1
HgenePIK3R3chr1:46543187chr1:46752171ENST00000423209-39358_452104403.0DomainSH2 2
HgenePIK3R3chr1:46543187chr1:46752171ENST00000423209-3965_160104403.0DomainSH2 1
TgeneLRRC41chr1:46527601chr1:46747057ENST00000343304310487_507498813.0RepeatNote=LRR 1


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Fusion Gene Sequence for PIK3R3-LRRC41


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>65400_65400_1_PIK3R3-LRRC41_PIK3R3_chr1_46527601_ENST00000372006_LRRC41_chr1_46747057_ENST00000343304_length(transcript)=2273nt_BP=864nt
ACAGAATCCCGGTACATCGAGGCGGGACGGCGTGGAAGGGGCGGTGGTGATGCCTGCTGTCCCCCCTCCCGGCGCGGTTGGGTGGCGCCT
CAGCGGCGCGATGTACAATACGGTGTGGAGTATGGACCGCGATGACGCAGACTGGAGGGAGGTGATGATGCCCTATTCGACAGAACTGAT
ATTTTATATTGAAATGGATCCTCCAGCTCTTCCACCAAAGCCACCTAAGCCAATGACTTCAGCAGTTCCAAATGGAATGAAGGACAGTTC
TGTTTCTCTTCAGGATGCAGAATGGTACTGGGGGGATATTTCAAGGGAGGAGGTAAATGACAAATTGCGGGATATGCCAGATGGGACCTT
CTTGGTCCGAGATGCCTCAACAAAAATGCAGGGAGATTATACTTTGACTTTGCGGAAGGGAGGCAATAATAAGTTAATAAAGATCTATCA
CCGGGATGGTAAATATGGCTTTTCTGATCCTCTGACATTTAATTCCGTGGTGGAGCTCATTAACCACTATCACCATGAATCTCTTGCTCA
GTACAATCCCAAACTTGATGTGAAGCTGATGTACCCAGTGTCCAGATACCAACAGGATCAGTTGGTAAAAGAAGATAATATTGATGCAGT
AGGTAAAAAACTGCAAGAATACCACTCTCAGTATCAGGAGAAGAGTAAAGAGTATGATAGGCTGTATGAAGAATATACTAGAACATCCCA
GGAAATACAGATGAAGAGGACTGCAATAGAAGCTTTTAATGAAACAATTAAAATATTTGAAGAGCAGTGTCACACACAAGAACAACATAG
CAAAGAATATATTGAGCGATTTCGCAGAGAGGGGAATGAAAAGGAGATTGAACGGCCTGGGCTCTAACATCTTCCGCCTGCTAGACAGCC
TGCGGGCCCTGTCAGGCCAGGCTGGATGTCGCCTCCGTGCCCTGCATCTCAGTGACCTGTTCTCACCACTGCCCATCCTGGAGCTGACAC
GTGCTATCGTGCGAGCACTGCCCCTGCTACGGGTCCTCTCTATTCGTGTTGACCACCCAAGCCAGCGGGACAACCCTGGTGTGCCAGGGA
ATGCAGGGCCCCCTAGCCACATAATAGGCGATGAGGAGATACCAGAAAACTGCCTGGAGCAGTTGGAGATGGGATTTCCACGGGGAGCCC
AGCCAGCCCCACTGCTGTGCTCCGTTCTGAAGGCCTCGGGTTCTCTGCAGCAGCTGTCCCTGGATAGTGCCACCTTTGCCTCTCCCCAGG
ATTTTGGGCTTGTTTTGCAAACACTCAAAGAGTACAACCTAGCCCTGAAAAGACTGAGCTTCCATGACATGAATCTCGCTGACTGTCAGA
GCGAGGTGCTCTTTTTGCTACAGAATCTGACTCTGCAAGAGATTACCTTCTCCTTCTGCCGTCTGTTTGAGAAGCGCCCAGCCCAATTTC
TGCCTGAGATGGTTGCTGCTATGAAGGGCAACTCCACACTGAAGGGCCTCCGGCTGCCAGGGAACCGCCTGGGGAATGCTGGCCTGCTGG
CCTTGGCAGATGTTTTCTCAGAGGATTCATCCTCCTCTCTCTGTCAGCTGGACATCAGTTCCAACTGCATCAAGCCAGATGGGCTTCTGG
AGTTCGCCAAGCGGCTGGAGCGCTGGGGCCGTGGAGCCTTTGGTCACCTGCGCCTCTTCCAAAACTGGCTGGACCAGGATGCAGTCACAG
CCAGGGAAGCCATCCGGCGGCTCCGGGCTACCTGCCATGTGGTTAGCGACTCATGGGACTCATCCCAGGCCTTCGCAGATTATGTTAGCA
CCATGTGATGGGGCCCGTACCTCACAGTCTCATGCTCGGTACCATCAGCTTGCAGGGGCTGAAGCATGGGCTGCCCAGAACCCCAACCAC
CAGTTCTATCTTTCTCTTTCTGTCACCTTTTTTCTCTTTTTTCCTTCTTCCCTTGCACTGAGGTCCTGGAGGCCTTGATGAGGCCCAGCA
AACAGGCATTCTCACAGCTGGGTTTATAGTCTTTGGGCCCCTTACTCAGTATCCTGGGAACCCTGGGCCAGGAGGTTACAGTGGTCATCA
TAATTGCTGAAGAGATCCCCTCCCCTGCCCCTGGGTTCCTGCCTTCCCTCCTCAAGCAGGCACCCAGGCTTTAGAGAAGTATAGGGGGCT
TCTTCCCTGCTGGGCTTACCACACTGCTCTCAGGCCTCAAACCCTTTCATACCTTTATTCTTTTTTTTAACCAAAAAAGTTTTTCTTATA

>65400_65400_1_PIK3R3-LRRC41_PIK3R3_chr1_46527601_ENST00000372006_LRRC41_chr1_46747057_ENST00000343304_length(amino acids)=349AA_BP=30
MKQLKYLKSSVTHKNNIAKNILSDFAERGMKRRLNGLGSNIFRLLDSLRALSGQAGCRLRALHLSDLFSPLPILELTRAIVRALPLLRVL
SIRVDHPSQRDNPGVPGNAGPPSHIIGDEEIPENCLEQLEMGFPRGAQPAPLLCSVLKASGSLQQLSLDSATFASPQDFGLVLQTLKEYN
LALKRLSFHDMNLADCQSEVLFLLQNLTLQEITFSFCRLFEKRPAQFLPEMVAAMKGNSTLKGLRLPGNRLGNAGLLALADVFSEDSSSS

--------------------------------------------------------------
>65400_65400_2_PIK3R3-LRRC41_PIK3R3_chr1_46543187_ENST00000340332_LRRC41_chr1_46752171_ENST00000343304_length(transcript)=3010nt_BP=463nt
AACCGGCCTCAGCCAATCACCACCCACCTTGCCTCTCTTCCCTCGCCCCACTCCCTCCTCGCCTGGCTCGCGTGCTCCCGGCACTGACTC
CTGGAGTGCGGCCAGCGCCCGGATCGTACCATTCTGATTGAGGCTGGGGGAGAGCGCGGATGGCTGATTGGGGAGCCGAAGCCTAGAGAG
CGGTGGGGAGACGTGAAAGTCGAGATGGAGAGCAGCTTTTTGAACATGTTCTCAGGCACTTGACAGAATCCCGCGCGATGTACAATACGG
TGTGGAGTATGGACCGCGATGACGCAGACTGGAGGGAGGTGATGATGCCCTATTCGACAGAACTGATATTTTATATTGAAATGGATCCTC
CAGCTGCGGAGGTAAATGACAAATTGCGGGATATGCCAGATGGGACCTTCTTGGTCCGAGATGCCTCAACAAAAATGCAGGGAGATTATA
CTTTGACTTTGCGAGTGTGACATGTTGGCGAGCCAAGTTTATGGAGGCCTTTTTTTCCCATGTTCTACGTGGGACCATTGATGTGTCTTC
TGACAGGCGTCTTTGTGATCAGCGGTTCTCACCTCTTCTGCACAGCTCCCGCCATGTCCGACAGCTCACCATCTGTAACATGCTGCAGGG
TGCAACCGAGCTGGTGGCTGAGCCCAACCGCAGGGTTCTGGAGACCCTGGCCAGCTCCCTGCACACTCTCAAGTTCCGCCACCTGCTGTT
CTCTGATGTGGCTGCTCAGCAGTCACTTCGGCAGCTGTTGCATCAGCTCATTCACCATGGGGCTGTCAGTCAAGTGTCGCTATACTCCTG
GCCTGTGCCTGAGTCAGCCCTTTTCATCCTTATTCTCACCATGAGTGCTGGCTTCTGGCAACCAGGGCCTGGTGGCCCACCCTGCCGCCT
CTGTGGAGAGGCCTCCCGAGGCCGGGCCCCATCCCGAGATGAAGGGTCCCTCTTATTGGGCTCACGTCGGCCCCGCCGGGATGCTGCTGA
GCGATGTGCTGCAGCCCTGATGGCCAGCCGGCGTAAGAGTGAAGCCAAGCAGATGCCCAGAGCTGCACCTGCCACTCGGGTAACACGCCG
GAGCACACAGGAGAGCCTGACAGCAGGCGGAACAGACCTTAAGAGGGAGCTGCACCCCCCAGCCACCTCCCATGAGGCTCCTGGCACCAA
GCGGTCACCTTCTGCTCCAGCAGCCACCTCCTCTGCCTCTTCTTCTACATCCTCATACAAACGGGCACCAGCTAGCTCAGCCCCACAGCC
TAAGCCCCTAAAGCGTTTCAAGCGAGCTGCAGGGAAGAAGGGTGCTCGCACCCGTCAGGGGCCTGGTGCAGAGTCTGAAGACCTGTATGA
CTTCGTTTTTATTGTGGCTGGCGAGAAGGAGGATGGCGAAGAGATGGAGATTGGGGAAGTGGCTTGTGGAGCTTTGGATGGATCAGATCC
CAGCTGCCTGGGGCTTCCAGCACTGGAAGCTTCACAAAGATTCCGCAGCATCTCCACCTTGGAGCTATTCACAGTTCCACTCTCCACAGA
GGCAGCCCTGACACTATGCCACCTGCTGAGCTCCTGGGTGTCACTGGAGAGCCTCACACTCTCCTACAATGGCCTGGGCTCTAACATCTT
CCGCCTGCTAGACAGCCTGCGGGCCCTGTCAGGCCAGGCTGGATGTCGCCTCCGTGCCCTGCATCTCAGTGACCTGTTCTCACCACTGCC
CATCCTGGAGCTGACACGTGCTATCGTGCGAGCACTGCCCCTGCTACGGGTCCTCTCTATTCGTGTTGACCACCCAAGCCAGCGGGACAA
CCCTGGTGTGCCAGGGAATGCAGGGCCCCCTAGCCACATAATAGGCGATGAGGAGATACCAGAAAACTGCCTGGAGCAGTTGGAGATGGG
ATTTCCACGGGGAGCCCAGCCAGCCCCACTGCTGTGCTCCGTTCTGAAGGCCTCGGGTTCTCTGCAGCAGCTGTCCCTGGATAGTGCCAC
CTTTGCCTCTCCCCAGGATTTTGGGCTTGTTTTGCAAACACTCAAAGAGTACAACCTAGCCCTGAAAAGACTGAGCTTCCATGACATGAA
TCTCGCTGACTGTCAGAGCGAGGTGCTCTTTTTGCTACAGAATCTGACTCTGCAAGAGATTACCTTCTCCTTCTGCCGTCTGTTTGAGAA
GCGCCCAGCCCAATTTCTGCCTGAGATGGTTGCTGCTATGAAGGGCAACTCCACACTGAAGGGCCTCCGGCTGCCAGGGAACCGCCTGGG
GAATGCTGGCCTGCTGGCCTTGGCAGATGTTTTCTCAGAGGATTCATCCTCCTCTCTCTGTCAGCTGGACATCAGTTCCAACTGCATCAA
GCCAGATGGGCTTCTGGAGTTCGCCAAGCGGCTGGAGCGCTGGGGCCGTGGAGCCTTTGGTCACCTGCGCCTCTTCCAAAACTGGCTGGA
CCAGGATGCAGTCACAGCCAGGGAAGCCATCCGGCGGCTCCGGGCTACCTGCCATGTGGTTAGCGACTCATGGGACTCATCCCAGGCCTT
CGCAGATTATGTTAGCACCATGTGATGGGGCCCGTACCTCACAGTCTCATGCTCGGTACCATCAGCTTGCAGGGGCTGAAGCATGGGCTG
CCCAGAACCCCAACCACCAGTTCTATCTTTCTCTTTCTGTCACCTTTTTTCTCTTTTTTCCTTCTTCCCTTGCACTGAGGTCCTGGAGGC
CTTGATGAGGCCCAGCAAACAGGCATTCTCACAGCTGGGTTTATAGTCTTTGGGCCCCTTACTCAGTATCCTGGGAACCCTGGGCCAGGA
GGTTACAGTGGTCATCATAATTGCTGAAGAGATCCCCTCCCCTGCCCCTGGGTTCCTGCCTTCCCTCCTCAAGCAGGCACCCAGGCTTTA
GAGAAGTATAGGGGGCTTCTTCCCTGCTGGGCTTACCACACTGCTCTCAGGCCTCAAACCCTTTCATACCTTTATTCTTTTTTTTAACCA

>65400_65400_2_PIK3R3-LRRC41_PIK3R3_chr1_46543187_ENST00000340332_LRRC41_chr1_46752171_ENST00000343304_length(amino acids)=684AA_BP=
MEAFFSHVLRGTIDVSSDRRLCDQRFSPLLHSSRHVRQLTICNMLQGATELVAEPNRRVLETLASSLHTLKFRHLLFSDVAAQQSLRQLL
HQLIHHGAVSQVSLYSWPVPESALFILILTMSAGFWQPGPGGPPCRLCGEASRGRAPSRDEGSLLLGSRRPRRDAAERCAAALMASRRKS
EAKQMPRAAPATRVTRRSTQESLTAGGTDLKRELHPPATSHEAPGTKRSPSAPAATSSASSSTSSYKRAPASSAPQPKPLKRFKRAAGKK
GARTRQGPGAESEDLYDFVFIVAGEKEDGEEMEIGEVACGALDGSDPSCLGLPALEASQRFRSISTLELFTVPLSTEAALTLCHLLSSWV
SLESLTLSYNGLGSNIFRLLDSLRALSGQAGCRLRALHLSDLFSPLPILELTRAIVRALPLLRVLSIRVDHPSQRDNPGVPGNAGPPSHI
IGDEEIPENCLEQLEMGFPRGAQPAPLLCSVLKASGSLQQLSLDSATFASPQDFGLVLQTLKEYNLALKRLSFHDMNLADCQSEVLFLLQ
NLTLQEITFSFCRLFEKRPAQFLPEMVAAMKGNSTLKGLRLPGNRLGNAGLLALADVFSEDSSSSLCQLDISSNCIKPDGLLEFAKRLER

--------------------------------------------------------------
>65400_65400_3_PIK3R3-LRRC41_PIK3R3_chr1_46543187_ENST00000354242_LRRC41_chr1_46752171_ENST00000343304_length(transcript)=3118nt_BP=571nt
AACCGGCCTCAGCCAATCACCACCCACCTTGCCTCTCTTCCCTCGCCCCACTCCCTCCTCGCCTGGCTCGCGTGCTCCCGGCACTGACTC
CTGGAGTGCGGCCAGCGCCCGGATCGTACCATTCTGATTGAGGCTGGGGGAGAGCGCGGATGGCTGATTGGGGAGCCGAAGCCTAGAGAG
CGGTGGGGAGACGTGAAAGTCGAGATGGAGAGCAGCTTTTTGAACATGTTCTCAGGCACTTGACAGAATCCCGCGCGATGTACAATACGG
TGTGGAGTATGGACCGCGATGACGCAGACTGGAGGGAGGTGATGATGCCCTATTCGACAGAACTGATATTTTATATTGAAATGGATCCTC
CAGCTCTTCCACCAAAGCCACCTAAGCCAATGACTTCAGCAGTTCCAAATGGAATGAAGGACAGTTCTGTTTCTCTTCAGGATGCAGAAT
GGTACTGGGGGGATATTTCAAGGGAGGAGGTAAATGACAAATTGCGGGATATGCCAGATGGGACCTTCTTGGTCCGAGATGCCTCAACAA
AAATGCAGGGAGATTATACTTTGACTTTGCGAGTGTGACATGTTGGCGAGCCAAGTTTATGGAGGCCTTTTTTTCCCATGTTCTACGTGG
GACCATTGATGTGTCTTCTGACAGGCGTCTTTGTGATCAGCGGTTCTCACCTCTTCTGCACAGCTCCCGCCATGTCCGACAGCTCACCAT
CTGTAACATGCTGCAGGGTGCAACCGAGCTGGTGGCTGAGCCCAACCGCAGGGTTCTGGAGACCCTGGCCAGCTCCCTGCACACTCTCAA
GTTCCGCCACCTGCTGTTCTCTGATGTGGCTGCTCAGCAGTCACTTCGGCAGCTGTTGCATCAGCTCATTCACCATGGGGCTGTCAGTCA
AGTGTCGCTATACTCCTGGCCTGTGCCTGAGTCAGCCCTTTTCATCCTTATTCTCACCATGAGTGCTGGCTTCTGGCAACCAGGGCCTGG
TGGCCCACCCTGCCGCCTCTGTGGAGAGGCCTCCCGAGGCCGGGCCCCATCCCGAGATGAAGGGTCCCTCTTATTGGGCTCACGTCGGCC
CCGCCGGGATGCTGCTGAGCGATGTGCTGCAGCCCTGATGGCCAGCCGGCGTAAGAGTGAAGCCAAGCAGATGCCCAGAGCTGCACCTGC
CACTCGGGTAACACGCCGGAGCACACAGGAGAGCCTGACAGCAGGCGGAACAGACCTTAAGAGGGAGCTGCACCCCCCAGCCACCTCCCA
TGAGGCTCCTGGCACCAAGCGGTCACCTTCTGCTCCAGCAGCCACCTCCTCTGCCTCTTCTTCTACATCCTCATACAAACGGGCACCAGC
TAGCTCAGCCCCACAGCCTAAGCCCCTAAAGCGTTTCAAGCGAGCTGCAGGGAAGAAGGGTGCTCGCACCCGTCAGGGGCCTGGTGCAGA
GTCTGAAGACCTGTATGACTTCGTTTTTATTGTGGCTGGCGAGAAGGAGGATGGCGAAGAGATGGAGATTGGGGAAGTGGCTTGTGGAGC
TTTGGATGGATCAGATCCCAGCTGCCTGGGGCTTCCAGCACTGGAAGCTTCACAAAGATTCCGCAGCATCTCCACCTTGGAGCTATTCAC
AGTTCCACTCTCCACAGAGGCAGCCCTGACACTATGCCACCTGCTGAGCTCCTGGGTGTCACTGGAGAGCCTCACACTCTCCTACAATGG
CCTGGGCTCTAACATCTTCCGCCTGCTAGACAGCCTGCGGGCCCTGTCAGGCCAGGCTGGATGTCGCCTCCGTGCCCTGCATCTCAGTGA
CCTGTTCTCACCACTGCCCATCCTGGAGCTGACACGTGCTATCGTGCGAGCACTGCCCCTGCTACGGGTCCTCTCTATTCGTGTTGACCA
CCCAAGCCAGCGGGACAACCCTGGTGTGCCAGGGAATGCAGGGCCCCCTAGCCACATAATAGGCGATGAGGAGATACCAGAAAACTGCCT
GGAGCAGTTGGAGATGGGATTTCCACGGGGAGCCCAGCCAGCCCCACTGCTGTGCTCCGTTCTGAAGGCCTCGGGTTCTCTGCAGCAGCT
GTCCCTGGATAGTGCCACCTTTGCCTCTCCCCAGGATTTTGGGCTTGTTTTGCAAACACTCAAAGAGTACAACCTAGCCCTGAAAAGACT
GAGCTTCCATGACATGAATCTCGCTGACTGTCAGAGCGAGGTGCTCTTTTTGCTACAGAATCTGACTCTGCAAGAGATTACCTTCTCCTT
CTGCCGTCTGTTTGAGAAGCGCCCAGCCCAATTTCTGCCTGAGATGGTTGCTGCTATGAAGGGCAACTCCACACTGAAGGGCCTCCGGCT
GCCAGGGAACCGCCTGGGGAATGCTGGCCTGCTGGCCTTGGCAGATGTTTTCTCAGAGGATTCATCCTCCTCTCTCTGTCAGCTGGACAT
CAGTTCCAACTGCATCAAGCCAGATGGGCTTCTGGAGTTCGCCAAGCGGCTGGAGCGCTGGGGCCGTGGAGCCTTTGGTCACCTGCGCCT
CTTCCAAAACTGGCTGGACCAGGATGCAGTCACAGCCAGGGAAGCCATCCGGCGGCTCCGGGCTACCTGCCATGTGGTTAGCGACTCATG
GGACTCATCCCAGGCCTTCGCAGATTATGTTAGCACCATGTGATGGGGCCCGTACCTCACAGTCTCATGCTCGGTACCATCAGCTTGCAG
GGGCTGAAGCATGGGCTGCCCAGAACCCCAACCACCAGTTCTATCTTTCTCTTTCTGTCACCTTTTTTCTCTTTTTTCCTTCTTCCCTTG
CACTGAGGTCCTGGAGGCCTTGATGAGGCCCAGCAAACAGGCATTCTCACAGCTGGGTTTATAGTCTTTGGGCCCCTTACTCAGTATCCT
GGGAACCCTGGGCCAGGAGGTTACAGTGGTCATCATAATTGCTGAAGAGATCCCCTCCCCTGCCCCTGGGTTCCTGCCTTCCCTCCTCAA
GCAGGCACCCAGGCTTTAGAGAAGTATAGGGGGCTTCTTCCCTGCTGGGCTTACCACACTGCTCTCAGGCCTCAAACCCTTTCATACCTT

>65400_65400_3_PIK3R3-LRRC41_PIK3R3_chr1_46543187_ENST00000354242_LRRC41_chr1_46752171_ENST00000343304_length(amino acids)=684AA_BP=
MEAFFSHVLRGTIDVSSDRRLCDQRFSPLLHSSRHVRQLTICNMLQGATELVAEPNRRVLETLASSLHTLKFRHLLFSDVAAQQSLRQLL
HQLIHHGAVSQVSLYSWPVPESALFILILTMSAGFWQPGPGGPPCRLCGEASRGRAPSRDEGSLLLGSRRPRRDAAERCAAALMASRRKS
EAKQMPRAAPATRVTRRSTQESLTAGGTDLKRELHPPATSHEAPGTKRSPSAPAATSSASSSTSSYKRAPASSAPQPKPLKRFKRAAGKK
GARTRQGPGAESEDLYDFVFIVAGEKEDGEEMEIGEVACGALDGSDPSCLGLPALEASQRFRSISTLELFTVPLSTEAALTLCHLLSSWV
SLESLTLSYNGLGSNIFRLLDSLRALSGQAGCRLRALHLSDLFSPLPILELTRAIVRALPLLRVLSIRVDHPSQRDNPGVPGNAGPPSHI
IGDEEIPENCLEQLEMGFPRGAQPAPLLCSVLKASGSLQQLSLDSATFASPQDFGLVLQTLKEYNLALKRLSFHDMNLADCQSEVLFLLQ
NLTLQEITFSFCRLFEKRPAQFLPEMVAAMKGNSTLKGLRLPGNRLGNAGLLALADVFSEDSSSSLCQLDISSNCIKPDGLLEFAKRLER

--------------------------------------------------------------
>65400_65400_4_PIK3R3-LRRC41_PIK3R3_chr1_46543187_ENST00000420542_LRRC41_chr1_46752171_ENST00000343304_length(transcript)=3118nt_BP=571nt
AACCGGCCTCAGCCAATCACCACCCACCTTGCCTCTCTTCCCTCGCCCCACTCCCTCCTCGCCTGGCTCGCGTGCTCCCGGCACTGACTC
CTGGAGTGCGGCCAGCGCCCGGATCGTACCATTCTGATTGAGGCTGGGGGAGAGCGCGGATGGCTGATTGGGGAGCCGAAGCCTAGAGAG
CGGTGGGGAGACGTGAAAGTCGAGATGGAGAGCAGCTTTTTGAACATGTTCTCAGGCACTTGACAGAATCCCGCGCGATGTACAATACGG
TGTGGAGTATGGACCGCGATGACGCAGACTGGAGGGAGGTGATGATGCCCTATTCGACAGAACTGATATTTTATATTGAAATGGATCCTC
CAGCTCTTCCACCAAAGCCACCTAAGCCAATGACTTCAGCAGTTCCAAATGGAATGAAGGACAGTTCTGTTTCTCTTCAGGATGCAGAAT
GGTACTGGGGGGATATTTCAAGGGAGGAGGTAAATGACAAATTGCGGGATATGCCAGATGGGACCTTCTTGGTCCGAGATGCCTCAACAA
AAATGCAGGGAGATTATACTTTGACTTTGCGAGTGTGACATGTTGGCGAGCCAAGTTTATGGAGGCCTTTTTTTCCCATGTTCTACGTGG
GACCATTGATGTGTCTTCTGACAGGCGTCTTTGTGATCAGCGGTTCTCACCTCTTCTGCACAGCTCCCGCCATGTCCGACAGCTCACCAT
CTGTAACATGCTGCAGGGTGCAACCGAGCTGGTGGCTGAGCCCAACCGCAGGGTTCTGGAGACCCTGGCCAGCTCCCTGCACACTCTCAA
GTTCCGCCACCTGCTGTTCTCTGATGTGGCTGCTCAGCAGTCACTTCGGCAGCTGTTGCATCAGCTCATTCACCATGGGGCTGTCAGTCA
AGTGTCGCTATACTCCTGGCCTGTGCCTGAGTCAGCCCTTTTCATCCTTATTCTCACCATGAGTGCTGGCTTCTGGCAACCAGGGCCTGG
TGGCCCACCCTGCCGCCTCTGTGGAGAGGCCTCCCGAGGCCGGGCCCCATCCCGAGATGAAGGGTCCCTCTTATTGGGCTCACGTCGGCC
CCGCCGGGATGCTGCTGAGCGATGTGCTGCAGCCCTGATGGCCAGCCGGCGTAAGAGTGAAGCCAAGCAGATGCCCAGAGCTGCACCTGC
CACTCGGGTAACACGCCGGAGCACACAGGAGAGCCTGACAGCAGGCGGAACAGACCTTAAGAGGGAGCTGCACCCCCCAGCCACCTCCCA
TGAGGCTCCTGGCACCAAGCGGTCACCTTCTGCTCCAGCAGCCACCTCCTCTGCCTCTTCTTCTACATCCTCATACAAACGGGCACCAGC
TAGCTCAGCCCCACAGCCTAAGCCCCTAAAGCGTTTCAAGCGAGCTGCAGGGAAGAAGGGTGCTCGCACCCGTCAGGGGCCTGGTGCAGA
GTCTGAAGACCTGTATGACTTCGTTTTTATTGTGGCTGGCGAGAAGGAGGATGGCGAAGAGATGGAGATTGGGGAAGTGGCTTGTGGAGC
TTTGGATGGATCAGATCCCAGCTGCCTGGGGCTTCCAGCACTGGAAGCTTCACAAAGATTCCGCAGCATCTCCACCTTGGAGCTATTCAC
AGTTCCACTCTCCACAGAGGCAGCCCTGACACTATGCCACCTGCTGAGCTCCTGGGTGTCACTGGAGAGCCTCACACTCTCCTACAATGG
CCTGGGCTCTAACATCTTCCGCCTGCTAGACAGCCTGCGGGCCCTGTCAGGCCAGGCTGGATGTCGCCTCCGTGCCCTGCATCTCAGTGA
CCTGTTCTCACCACTGCCCATCCTGGAGCTGACACGTGCTATCGTGCGAGCACTGCCCCTGCTACGGGTCCTCTCTATTCGTGTTGACCA
CCCAAGCCAGCGGGACAACCCTGGTGTGCCAGGGAATGCAGGGCCCCCTAGCCACATAATAGGCGATGAGGAGATACCAGAAAACTGCCT
GGAGCAGTTGGAGATGGGATTTCCACGGGGAGCCCAGCCAGCCCCACTGCTGTGCTCCGTTCTGAAGGCCTCGGGTTCTCTGCAGCAGCT
GTCCCTGGATAGTGCCACCTTTGCCTCTCCCCAGGATTTTGGGCTTGTTTTGCAAACACTCAAAGAGTACAACCTAGCCCTGAAAAGACT
GAGCTTCCATGACATGAATCTCGCTGACTGTCAGAGCGAGGTGCTCTTTTTGCTACAGAATCTGACTCTGCAAGAGATTACCTTCTCCTT
CTGCCGTCTGTTTGAGAAGCGCCCAGCCCAATTTCTGCCTGAGATGGTTGCTGCTATGAAGGGCAACTCCACACTGAAGGGCCTCCGGCT
GCCAGGGAACCGCCTGGGGAATGCTGGCCTGCTGGCCTTGGCAGATGTTTTCTCAGAGGATTCATCCTCCTCTCTCTGTCAGCTGGACAT
CAGTTCCAACTGCATCAAGCCAGATGGGCTTCTGGAGTTCGCCAAGCGGCTGGAGCGCTGGGGCCGTGGAGCCTTTGGTCACCTGCGCCT
CTTCCAAAACTGGCTGGACCAGGATGCAGTCACAGCCAGGGAAGCCATCCGGCGGCTCCGGGCTACCTGCCATGTGGTTAGCGACTCATG
GGACTCATCCCAGGCCTTCGCAGATTATGTTAGCACCATGTGATGGGGCCCGTACCTCACAGTCTCATGCTCGGTACCATCAGCTTGCAG
GGGCTGAAGCATGGGCTGCCCAGAACCCCAACCACCAGTTCTATCTTTCTCTTTCTGTCACCTTTTTTCTCTTTTTTCCTTCTTCCCTTG
CACTGAGGTCCTGGAGGCCTTGATGAGGCCCAGCAAACAGGCATTCTCACAGCTGGGTTTATAGTCTTTGGGCCCCTTACTCAGTATCCT
GGGAACCCTGGGCCAGGAGGTTACAGTGGTCATCATAATTGCTGAAGAGATCCCCTCCCCTGCCCCTGGGTTCCTGCCTTCCCTCCTCAA
GCAGGCACCCAGGCTTTAGAGAAGTATAGGGGGCTTCTTCCCTGCTGGGCTTACCACACTGCTCTCAGGCCTCAAACCCTTTCATACCTT

>65400_65400_4_PIK3R3-LRRC41_PIK3R3_chr1_46543187_ENST00000420542_LRRC41_chr1_46752171_ENST00000343304_length(amino acids)=684AA_BP=
MEAFFSHVLRGTIDVSSDRRLCDQRFSPLLHSSRHVRQLTICNMLQGATELVAEPNRRVLETLASSLHTLKFRHLLFSDVAAQQSLRQLL
HQLIHHGAVSQVSLYSWPVPESALFILILTMSAGFWQPGPGGPPCRLCGEASRGRAPSRDEGSLLLGSRRPRRDAAERCAAALMASRRKS
EAKQMPRAAPATRVTRRSTQESLTAGGTDLKRELHPPATSHEAPGTKRSPSAPAATSSASSSTSSYKRAPASSAPQPKPLKRFKRAAGKK
GARTRQGPGAESEDLYDFVFIVAGEKEDGEEMEIGEVACGALDGSDPSCLGLPALEASQRFRSISTLELFTVPLSTEAALTLCHLLSSWV
SLESLTLSYNGLGSNIFRLLDSLRALSGQAGCRLRALHLSDLFSPLPILELTRAIVRALPLLRVLSIRVDHPSQRDNPGVPGNAGPPSHI
IGDEEIPENCLEQLEMGFPRGAQPAPLLCSVLKASGSLQQLSLDSATFASPQDFGLVLQTLKEYNLALKRLSFHDMNLADCQSEVLFLLQ
NLTLQEITFSFCRLFEKRPAQFLPEMVAAMKGNSTLKGLRLPGNRLGNAGLLALADVFSEDSSSSLCQLDISSNCIKPDGLLEFAKRLER

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PIK3R3-LRRC41


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneLRRC41chr1:46527601chr1:46747057ENST0000034330431045_54498.3333333333333813.0Elongin BC complex
TgeneLRRC41chr1:46543187chr1:46752171ENST0000034330421045_54119.0813.0Elongin BC complex


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PIK3R3-LRRC41


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PIK3R3-LRRC41


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource