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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PIKFYVE-CAB39 (FusionGDB2 ID:65421)

Fusion Gene Summary for PIKFYVE-CAB39

check button Fusion gene summary
Fusion gene informationFusion gene name: PIKFYVE-CAB39
Fusion gene ID: 65421
HgeneTgene
Gene symbol

PIKFYVE

CAB39

Gene ID

200576

51719

Gene namephosphoinositide kinase, FYVE-type zinc finger containingcalcium binding protein 39
SynonymsCFD|FAB1|HEL37|PIP5K|PIP5K3|ZFYVE29CGI-66|MO25
Cytomap

2q34

2q37.1

Type of geneprotein-codingprotein-coding
Description1-phosphatidylinositol 3-phosphate 5-kinasePIPkin-IIIepididymis luminal protein 37phosphatidylinositol 3-phosphate 5-kinase type IIIphosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type IIIphosphoinositide kinase, FYVE finger containincalcium-binding protein 39MO25alpha
Modification date2020032720200313
UniProtAcc.

Q9H9S4

Ensembl transtripts involved in fusion geneENST00000264380, ENST00000308862, 
ENST00000392202, ENST00000407449, 
ENST00000474721, 		ENST00000484398, 
ENST00000258418, ENST00000409788, 
ENST00000410084, 
Fusion gene scores* DoF score8 X 7 X 6=3368 X 7 X 5=280
# samples 78
** MAII scorelog2(7/336*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/280*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PIKFYVE [Title/Abstract] AND CAB39 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPIKFYVE(209180097)-CAB39(231674978), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCAB39

GO:0010800

positive regulation of peptidyl-threonine phosphorylation

24393035

TgeneCAB39

GO:0018105

peptidyl-serine phosphorylation

24393035

TgeneCAB39

GO:0023014

signal transduction by protein phosphorylation

24393035

TgeneCAB39

GO:0035556

intracellular signal transduction

24393035

TgeneCAB39

GO:0071902

positive regulation of protein serine/threonine kinase activity

19892943|24393035


check buttonFusion gene breakpoints across PIKFYVE (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CAB39 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-A7-A0CH-11APIKFYVEchr2

209180097

+CAB39chr2

231674978

+


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Fusion Gene ORF analysis for PIKFYVE-CAB39

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000264380ENST00000484398PIKFYVEchr2

209180097

+CAB39chr2

231674978

+
In-frameENST00000264380ENST00000258418PIKFYVEchr2

209180097

+CAB39chr2

231674978

+
In-frameENST00000264380ENST00000409788PIKFYVEchr2

209180097

+CAB39chr2

231674978

+
In-frameENST00000264380ENST00000410084PIKFYVEchr2

209180097

+CAB39chr2

231674978

+
intron-3CDSENST00000308862ENST00000258418PIKFYVEchr2

209180097

+CAB39chr2

231674978

+
intron-3CDSENST00000308862ENST00000409788PIKFYVEchr2

209180097

+CAB39chr2

231674978

+
intron-3CDSENST00000308862ENST00000410084PIKFYVEchr2

209180097

+CAB39chr2

231674978

+
intron-3CDSENST00000392202ENST00000258418PIKFYVEchr2

209180097

+CAB39chr2

231674978

+
intron-3CDSENST00000392202ENST00000409788PIKFYVEchr2

209180097

+CAB39chr2

231674978

+
intron-3CDSENST00000392202ENST00000410084PIKFYVEchr2

209180097

+CAB39chr2

231674978

+
intron-3CDSENST00000407449ENST00000258418PIKFYVEchr2

209180097

+CAB39chr2

231674978

+
intron-3CDSENST00000407449ENST00000409788PIKFYVEchr2

209180097

+CAB39chr2

231674978

+
intron-3CDSENST00000407449ENST00000410084PIKFYVEchr2

209180097

+CAB39chr2

231674978

+
intron-3CDSENST00000474721ENST00000258418PIKFYVEchr2

209180097

+CAB39chr2

231674978

+
intron-3CDSENST00000474721ENST00000409788PIKFYVEchr2

209180097

+CAB39chr2

231674978

+
intron-3CDSENST00000474721ENST00000410084PIKFYVEchr2

209180097

+CAB39chr2

231674978

+
intron-intronENST00000308862ENST00000484398PIKFYVEchr2

209180097

+CAB39chr2

231674978

+
intron-intronENST00000392202ENST00000484398PIKFYVEchr2

209180097

+CAB39chr2

231674978

+
intron-intronENST00000407449ENST00000484398PIKFYVEchr2

209180097

+CAB39chr2

231674978

+
intron-intronENST00000474721ENST00000484398PIKFYVEchr2

209180097

+CAB39chr2

231674978

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000264380PIKFYVEchr2209180097+ENST00000258418CAB39chr2231674978+499521651582623821
ENST00000264380PIKFYVEchr2209180097+ENST00000410084CAB39chr2231674978+262421651582623822
ENST00000264380PIKFYVEchr2209180097+ENST00000409788CAB39chr2231674978+267021651582623821

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000264380ENST00000258418PIKFYVEchr2209180097+CAB39chr2231674978+0.0011660.99883395
ENST00000264380ENST00000410084PIKFYVEchr2209180097+CAB39chr2231674978+0.0055382660.9944617
ENST00000264380ENST00000409788PIKFYVEchr2209180097+CAB39chr2231674978+0.0050886440.9949114

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Fusion Genomic Features for PIKFYVE-CAB39


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PIKFYVEchr2209180097+CAB39chr2231674977+2.62E-060.9999974
PIKFYVEchr2209180097+CAB39chr2231674977+2.62E-060.9999974

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PIKFYVE-CAB39


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:209180097/chr2:231674978)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CAB39

Q9H9S4

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1 (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePIKFYVEchr2:209180097chr2:231674978ENST00000264380+1542365_4406692099.0DomainDEP
HgenePIKFYVEchr2:209180097chr2:231674978ENST00000264380+1542158_2186692099.0Zinc fingerFYVE-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePIKFYVEchr2:209180097chr2:231674978ENST00000264380+15421758_20846692099.0DomainPIPK
HgenePIKFYVEchr2:209180097chr2:231674978ENST00000308862+1111758_20840463.0DomainPIPK
HgenePIKFYVEchr2:209180097chr2:231674978ENST00000308862+111365_4400463.0DomainDEP
HgenePIKFYVEchr2:209180097chr2:231674978ENST00000392202+1101758_20840452.0DomainPIPK
HgenePIKFYVEchr2:209180097chr2:231674978ENST00000392202+110365_4400452.0DomainDEP
HgenePIKFYVEchr2:209180097chr2:231674978ENST00000407449+1121758_20840549.0DomainPIPK
HgenePIKFYVEchr2:209180097chr2:231674978ENST00000407449+112365_4400549.0DomainDEP
HgenePIKFYVEchr2:209180097chr2:231674978ENST00000264380+15421842_20986692099.0RegionNote=Catalytic
HgenePIKFYVEchr2:209180097chr2:231674978ENST00000264380+1542616_8686692099.0RegionChaperonin-like domain
HgenePIKFYVEchr2:209180097chr2:231674978ENST00000308862+1111842_20980463.0RegionNote=Catalytic
HgenePIKFYVEchr2:209180097chr2:231674978ENST00000308862+111616_8680463.0RegionChaperonin-like domain
HgenePIKFYVEchr2:209180097chr2:231674978ENST00000392202+1101842_20980452.0RegionNote=Catalytic
HgenePIKFYVEchr2:209180097chr2:231674978ENST00000392202+110616_8680452.0RegionChaperonin-like domain
HgenePIKFYVEchr2:209180097chr2:231674978ENST00000407449+1121842_20980549.0RegionNote=Catalytic
HgenePIKFYVEchr2:209180097chr2:231674978ENST00000407449+112616_8680549.0RegionChaperonin-like domain
HgenePIKFYVEchr2:209180097chr2:231674978ENST00000308862+111158_2180463.0Zinc fingerFYVE-type
HgenePIKFYVEchr2:209180097chr2:231674978ENST00000392202+110158_2180452.0Zinc fingerFYVE-type
HgenePIKFYVEchr2:209180097chr2:231674978ENST00000407449+112158_2180549.0Zinc fingerFYVE-type


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Fusion Gene Sequence for PIKFYVE-CAB39


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>65421_65421_1_PIKFYVE-CAB39_PIKFYVE_chr2_209180097_ENST00000264380_CAB39_chr2_231674978_ENST00000258418_length(transcript)=4995nt_BP=2165nt
CAACCATGTAAGCAGCTTCGCTTCCTGCCGCAACCGTCCGCGGCCTGAGGAGCCCACCGCCGCTCTCGGGGGCCGACTTCCGGGGGCTGA
GCCGTTGAAGCGGAGGCTGGGGCGGGGGGCAGCCGGCGCGGCCGGGGCAGGAGGCGCAGACTCATGAAATGGCCACAGATGATAAGACGT
CCCCAACACTGGACTCTGCTAATGATTTGCCTCGATCTCCTACTAGTCCTTCTCATCTCACACACTTTAAACCTTTGACTCCTGATCAAG
ATGAGCCCCCTTTTAAATCAGCTTATAGTTCTTTTGTAAATCTCTTTCGTTTTAACAAAGAGAGAGCAGAAGGAGGCCAGGGAGAACAGC
AGCCTTTGAGTGGAAGTTGGACCAGCCCTCAGCTCCCTTCGAGGACACAGTCTGTTAGGTCACCCACACCTTATAAAAAGCAGCTTAATG
AGGAACTCCAGCGGCGCTCTTCAGCATTAGACACAAGAAGGAAAGCAGAACCTACCTTTGGAGGTCATGACCCTCGTACAGCTGTTCAGC
TTCGAAGCCTCAGCACAGTATTAAAACGCCTCAAGGAAATCATGGAGGGGAAAAGCCAGGATAGTGACCTGAAACAATACTGGATGCCAG
ATAGCCAATGTAAAGAGTGCTATGACTGTAGTGAGAAATTTACAACCTTTAGGCGCAGACACCATTGCCGACTATGTGGGCAGATTTTCT
GCAGTCGTTGCTGTAATCAAGAAATCCCTGGAAAATTTATGGGCTATACAGGAGACCTCCGAGCTTGCACATATTGTAGAAAAATAGCCT
TAAGTTATGCTCATTCCACAGACAGTAATTCTATTGGGGAAGACTTGAATGCTCTTTCAGATTCTGCTTGCTCTGTGTCTGTGCTTGATC
CAAGTGAACCCCGAACACCTGTTGGGAGTAGGAAAGCCAGCCGTAACATATTTTTAGAGGATGATTTGGCCTGGCAAAGTTTGATTCATC
CAGATTCCTCAAATACTCCTCTTTCAACAAGACTTGTATCTGTGCAAGAGGATGCTGGGAAATCTCCTGCTCGAAATAGATCAGCCAGCA
TTACTAACCTGTCACTGGATAGATCTGGTTCTCCTATGGTACCTTCATATGAGACATCTGTCAGTCCCCAGGCTAACCGAACATATGTTA
GGACAGAGACCACTGAGGATGAACGCAAAATTCTTCTGGACAGTGTGCAGTTAAAAGACCTGTGGAAAAAAATCTGCCATCACAGCAGTG
GAATGGAGTTTCAGGATCACCGCTACTGGTTGAGAACGCATCCCAACTGCATTGTAGGAAAGGAATTAGTCAACTGGCTAATCCGAAATG
GGCATATTGCCACAAGGGCACAAGCTATAGCAATTGGACAAGCAATGGTTGATGGACGTTGGCTGGATTGTGTTAGTCATCACGACCAGC
TTTTCAGAGATGAGTATGCGCTGTATAGACCACTGCAGAGTACAGAATTTTCTGAGACGCCTTCTCCCGACAGTGACTCAGTGAACTCCG
TGGAAGGACACTCTGAGCCATCCTGGTTTAAAGACATAAAGTTTGATGACAGTGACACAGAACAGATAGCTGAAGAAGGTGACGATAATT
TGGCTAATTCTGCCAGTCCTAGCAAGCGCACATCAGTCAGCAGTTTCCAGTCCACAGTGGACAGTGACTCAGCCGCTTCTATCAGCCTGA
ACGTGGAGCTGGACAACGTGAACTTCCATATCAAGAAGCCCTCCAAGTACCCACATGTGCCCCCTCACCCTGCTGACCAAAAAGAGTATT
TGATTTCTGACACTGGAGGACAACAGCTCTCAATAAGTGACGCTTTCATCAAAGAATCCTTATTTAATCGCCGAGTAGAGGAAAAATCCA
AAGAGCTGCCTTTCACACCTTTGGGCTGGCATCATAACAACCTGGAGCTCCTGAGGGAGGAGAATGGGGAGAAACAAGCCATGGAGAGGT
TGCTTTCAGCTAATCATAACCACATGATGGCACTACTCCAGCAGTTGCTCCATAGTGACTCACTGTCATCATCTTGGAGGGACATCATCG
TGTCATTGGTCTGCCAGGTTGTTCAGACAGTCCGACCTGATGTCAAGAACCAGGATGATGACATGGATATCCGTCAGTTTGTCCACATCA
AAAAAGATTTACTTACAAGACATAAATTGCTCAGTGCAGAATTTTTGGAACAGCATTATGATAGATTTTTCAGTGAATATGAGAAGTTAC
TTCATTCAGAAAATTATGTGACAAAAAGACAGTCACTGAAGCTTCTCGGTGAACTACTACTAGATAGACACAACTTCACAATTATGACAA
AATACATCAGTAAACCTGAGAACCTCAAATTAATGATGAACCTGCTGCGAGACAAAAGTCGCAACATCCAGTTTGAGGCCTTTCACGTTT
TTAAGGTGTTTGTAGCCAATCCTAACAAGACGCAGCCCATCCTAGACATCCTCCTCAAGAACCAGGCCAAACTCATAGAGTTCCTCAGCA
AGTTTCAGAACGACAGGACGGAGGATGAGCAGTTTAACGACGAGAAGACCTATTTAGTTAAACAGATCAGGGATTTGAAGAGACCAGCTC
AGCAAGAAGCTTAATCTCCAATAAACATCTATGTTAAATCCAAATTCAGCATTTGCTGTTAGCTATTCAGCATCAGGCACTCTTATTGAT
TCATGAGGAACATTACTGCTAATCTGCTGTTAAGTGAACGGTTTTTCATTTTACCCTTTTGTTTTTCAGTCCAGGTTGGAGATCGTAGCT
GCTGCTGCTTGCACACTAGGGCACATGTGGGCTTTCTCTTGATCTTTGTGTCATTTCAGAATTCAAAGACTGTGCTACGGGAGTTCTGAA
CATGGCTGGGTTCATGAAGGCAAATGTATGGATGAGAGTGTGGTTTAGGAAAGAGGGCACTGATATCAGATTAGACCTATGTGTTTGCAC
CCATCTTTGTTGGCGATCTGAGTGCAGTGTGGCAAGTGCACACCTGGCATCCCTGCGTCAGATCGCGCACCTTCAGGTCGCGCACCTTCG
CTGAAGGAAGATGACGCAGAGCTTTATCTGAAATCAGAGGGGAGCTATCCAAAATGGGAGTTTGGGGGCAGCTAAAGTTGACATGCGAAT
AAATTGATACTGAAACTTAGCAACTTCTTAAAAGTGTAAAGAAGCCTCATAAGATCATAAGGAAAATGTATATATGCTTTTCACAGCTTT
CTAGAATTTTTTGACATTTGATTTTCTTGAGACTTGTAAACCTGGATATGTTGAAGGGTATTTGTTAATTTTACTTTTCAAAGATACTTT
AAAACAGTAGAGCTAGCAATGACACCTTGCATTTCATTTCAACACTGCTTCAAGGTTTCTTTTGTATATAATTCTTAGAATGCTCATTTC
TTTTAAATGGTTTAATTTGTACAGCAGAGGAATGTTATTGTAGTAGTATGTAACTATTACCTAATACTGAGTTTTTGCAAAAAACAATGA
ATGCTCATATGTAATTGAAATACTTCAGATCACATGAAAATGCTGATTTAACATTTAAGTATCACAGCATTAAAAGAAAAAGAAAGTAAA
CCAGTCCTTTGTATTCAGTTACCTAATGGGGTGCCATCAATAAGCTGCGATACAGCCCTGGAGCTCAGTCAGCCACACCTTCCTGCATCC
TATTGGCCTTATTCATTTTAAATGAGTTAATGAATCTGCCAGATCTGTGAATGATAGAGATTATGCTAAATTAATGCTGATTCTTTGTGT
GTGTGGGAAATCTCTGTAGAGCACCTTTTCTTTCTTAGACTAAGTAACCCAGTACAATAGTTGTGAACTGAATAATTAAAACTTTGGCTT
CTCTTAGGAAAAGACGACTTCCTAGTCATAGGTGTCCTATGGGGAAATTTATTTTTTTTAATGTCCTGTTCCTTAATGCTGCAAATTATC
AGTATTTATAAAGTAACTGATTTTGCACCACTTTTTTGTTACTGTGACCACGGCAGAACAATGTCTTCTAGACTATATCTATGTAAAGTT
ATTAGAATGGTATCTGTTCATTTTAGTGATATGAAGATCACAACTAACAACTGACAAATCAGAGTTTGCCAGTTCAAATTCAGCATGGCT
GCAGCTGATTAAGAAATTGATATGATTATTCTTTGCTAGCCTCTCTTACTAATGGAATTATATACTGGCCAGTAAAATGGGCCTCCCAAT
TGCTGTTTCAGCAGGTTTTAAACCTTCAGGAACACCAGTTAGGAAAATAGCTCCAGAAAATATAGATATATTTTATTTTTATTAAAATGG
CAGTCTACATCATAATTGGCATTTCTCAAGACTGTCTTTACCAGAATCTGTGTGAAATAAGGCAATCTAGTCTCCTTGAAAAAAAAATCT
CTTGGATGTTTAGGAAGGAAGACTTGGCCGTGATGTGGTGTCCTGGCTTTGTGGTGTAGTGCTGTGTGTATGGAGTTAGTGTAAAAACAT
GGATTACACCAAGTGGAAGAAACGTCTTCTTGCCAAGCTCATTCTTAGAACTTACACATCTAGAACAGCTTCCACTTTGGCAGTGAGGTC
GTAGCCTTTTAGGTGGAAGAAGTGAGGGTGCAGCGTGTCAGACACAACATTCATGTTACTCTTACATTGGAATCTGAAGGTAGTTCAGAC
TTCGTGGGTTTTGTTTTTAAGCAAAACAATGTGAAAACATTTAAGTTTGAAATGTTGCATTTGAAGTTATGATCATTTAATATATTCATA
TTACCAAGACTATTATACTGGAAGTGGTTTTTGTGTTATAAAGGTTTAATTTTACATAAGGCAGTTACTTAATGTGATTTTTAACCCTTA
AAAAAGTGGAGATGTATACATTTGTTAACAATGCCATGAAAGCATTTTCTTTCTCCTAAGGAAAAGTGAATTTCTTATCAGAATATCTGG

>65421_65421_1_PIKFYVE-CAB39_PIKFYVE_chr2_209180097_ENST00000264380_CAB39_chr2_231674978_ENST00000258418_length(amino acids)=821AA_BP=669
MATDDKTSPTLDSANDLPRSPTSPSHLTHFKPLTPDQDEPPFKSAYSSFVNLFRFNKERAEGGQGEQQPLSGSWTSPQLPSRTQSVRSPT
PYKKQLNEELQRRSSALDTRRKAEPTFGGHDPRTAVQLRSLSTVLKRLKEIMEGKSQDSDLKQYWMPDSQCKECYDCSEKFTTFRRRHHC
RLCGQIFCSRCCNQEIPGKFMGYTGDLRACTYCRKIALSYAHSTDSNSIGEDLNALSDSACSVSVLDPSEPRTPVGSRKASRNIFLEDDL
AWQSLIHPDSSNTPLSTRLVSVQEDAGKSPARNRSASITNLSLDRSGSPMVPSYETSVSPQANRTYVRTETTEDERKILLDSVQLKDLWK
KICHHSSGMEFQDHRYWLRTHPNCIVGKELVNWLIRNGHIATRAQAIAIGQAMVDGRWLDCVSHHDQLFRDEYALYRPLQSTEFSETPSP
DSDSVNSVEGHSEPSWFKDIKFDDSDTEQIAEEGDDNLANSASPSKRTSVSSFQSTVDSDSAASISLNVELDNVNFHIKKPSKYPHVPPH
PADQKEYLISDTGGQQLSISDAFIKESLFNRRVEEKSKELPFTPLGWHHNNLELLREENGEKQAMERLLSANHNHMMALLQQLLHSDSLS
SSWRDIIVSLVCQVVQTVRPDVKNQDDDMDIRQFVHIKKDLLTRHKLLSAEFLEQHYDRFFSEYEKLLHSENYVTKRQSLKLLGELLLDR
HNFTIMTKYISKPENLKLMMNLLRDKSRNIQFEAFHVFKVFVANPNKTQPILDILLKNQAKLIEFLSKFQNDRTEDEQFNDEKTYLVKQI

--------------------------------------------------------------
>65421_65421_2_PIKFYVE-CAB39_PIKFYVE_chr2_209180097_ENST00000264380_CAB39_chr2_231674978_ENST00000409788_length(transcript)=2670nt_BP=2165nt
CAACCATGTAAGCAGCTTCGCTTCCTGCCGCAACCGTCCGCGGCCTGAGGAGCCCACCGCCGCTCTCGGGGGCCGACTTCCGGGGGCTGA
GCCGTTGAAGCGGAGGCTGGGGCGGGGGGCAGCCGGCGCGGCCGGGGCAGGAGGCGCAGACTCATGAAATGGCCACAGATGATAAGACGT
CCCCAACACTGGACTCTGCTAATGATTTGCCTCGATCTCCTACTAGTCCTTCTCATCTCACACACTTTAAACCTTTGACTCCTGATCAAG
ATGAGCCCCCTTTTAAATCAGCTTATAGTTCTTTTGTAAATCTCTTTCGTTTTAACAAAGAGAGAGCAGAAGGAGGCCAGGGAGAACAGC
AGCCTTTGAGTGGAAGTTGGACCAGCCCTCAGCTCCCTTCGAGGACACAGTCTGTTAGGTCACCCACACCTTATAAAAAGCAGCTTAATG
AGGAACTCCAGCGGCGCTCTTCAGCATTAGACACAAGAAGGAAAGCAGAACCTACCTTTGGAGGTCATGACCCTCGTACAGCTGTTCAGC
TTCGAAGCCTCAGCACAGTATTAAAACGCCTCAAGGAAATCATGGAGGGGAAAAGCCAGGATAGTGACCTGAAACAATACTGGATGCCAG
ATAGCCAATGTAAAGAGTGCTATGACTGTAGTGAGAAATTTACAACCTTTAGGCGCAGACACCATTGCCGACTATGTGGGCAGATTTTCT
GCAGTCGTTGCTGTAATCAAGAAATCCCTGGAAAATTTATGGGCTATACAGGAGACCTCCGAGCTTGCACATATTGTAGAAAAATAGCCT
TAAGTTATGCTCATTCCACAGACAGTAATTCTATTGGGGAAGACTTGAATGCTCTTTCAGATTCTGCTTGCTCTGTGTCTGTGCTTGATC
CAAGTGAACCCCGAACACCTGTTGGGAGTAGGAAAGCCAGCCGTAACATATTTTTAGAGGATGATTTGGCCTGGCAAAGTTTGATTCATC
CAGATTCCTCAAATACTCCTCTTTCAACAAGACTTGTATCTGTGCAAGAGGATGCTGGGAAATCTCCTGCTCGAAATAGATCAGCCAGCA
TTACTAACCTGTCACTGGATAGATCTGGTTCTCCTATGGTACCTTCATATGAGACATCTGTCAGTCCCCAGGCTAACCGAACATATGTTA
GGACAGAGACCACTGAGGATGAACGCAAAATTCTTCTGGACAGTGTGCAGTTAAAAGACCTGTGGAAAAAAATCTGCCATCACAGCAGTG
GAATGGAGTTTCAGGATCACCGCTACTGGTTGAGAACGCATCCCAACTGCATTGTAGGAAAGGAATTAGTCAACTGGCTAATCCGAAATG
GGCATATTGCCACAAGGGCACAAGCTATAGCAATTGGACAAGCAATGGTTGATGGACGTTGGCTGGATTGTGTTAGTCATCACGACCAGC
TTTTCAGAGATGAGTATGCGCTGTATAGACCACTGCAGAGTACAGAATTTTCTGAGACGCCTTCTCCCGACAGTGACTCAGTGAACTCCG
TGGAAGGACACTCTGAGCCATCCTGGTTTAAAGACATAAAGTTTGATGACAGTGACACAGAACAGATAGCTGAAGAAGGTGACGATAATT
TGGCTAATTCTGCCAGTCCTAGCAAGCGCACATCAGTCAGCAGTTTCCAGTCCACAGTGGACAGTGACTCAGCCGCTTCTATCAGCCTGA
ACGTGGAGCTGGACAACGTGAACTTCCATATCAAGAAGCCCTCCAAGTACCCACATGTGCCCCCTCACCCTGCTGACCAAAAAGAGTATT
TGATTTCTGACACTGGAGGACAACAGCTCTCAATAAGTGACGCTTTCATCAAAGAATCCTTATTTAATCGCCGAGTAGAGGAAAAATCCA
AAGAGCTGCCTTTCACACCTTTGGGCTGGCATCATAACAACCTGGAGCTCCTGAGGGAGGAGAATGGGGAGAAACAAGCCATGGAGAGGT
TGCTTTCAGCTAATCATAACCACATGATGGCACTACTCCAGCAGTTGCTCCATAGTGACTCACTGTCATCATCTTGGAGGGACATCATCG
TGTCATTGGTCTGCCAGGTTGTTCAGACAGTCCGACCTGATGTCAAGAACCAGGATGATGACATGGATATCCGTCAGTTTGTCCACATCA
AAAAAGATTTACTTACAAGACATAAATTGCTCAGTGCAGAATTTTTGGAACAGCATTATGATAGATTTTTCAGTGAATATGAGAAGTTAC
TTCATTCAGAAAATTATGTGACAAAAAGACAGTCACTGAAGCTTCTCGGTGAACTACTACTAGATAGACACAACTTCACAATTATGACAA
AATACATCAGTAAACCTGAGAACCTCAAATTAATGATGAACCTGCTGCGAGACAAAAGTCGCAACATCCAGTTTGAGGCCTTTCACGTTT
TTAAGGTGTTTGTAGCCAATCCTAACAAGACGCAGCCCATCCTAGACATCCTCCTCAAGAACCAGGCCAAACTCATAGAGTTCCTCAGCA
AGTTTCAGAACGACAGGACGGAGGATGAGCAGTTTAACGACGAGAAGACCTATTTAGTTAAACAGATCAGGGATTTGAAGAGACCAGCTC

>65421_65421_2_PIKFYVE-CAB39_PIKFYVE_chr2_209180097_ENST00000264380_CAB39_chr2_231674978_ENST00000409788_length(amino acids)=821AA_BP=669
MATDDKTSPTLDSANDLPRSPTSPSHLTHFKPLTPDQDEPPFKSAYSSFVNLFRFNKERAEGGQGEQQPLSGSWTSPQLPSRTQSVRSPT
PYKKQLNEELQRRSSALDTRRKAEPTFGGHDPRTAVQLRSLSTVLKRLKEIMEGKSQDSDLKQYWMPDSQCKECYDCSEKFTTFRRRHHC
RLCGQIFCSRCCNQEIPGKFMGYTGDLRACTYCRKIALSYAHSTDSNSIGEDLNALSDSACSVSVLDPSEPRTPVGSRKASRNIFLEDDL
AWQSLIHPDSSNTPLSTRLVSVQEDAGKSPARNRSASITNLSLDRSGSPMVPSYETSVSPQANRTYVRTETTEDERKILLDSVQLKDLWK
KICHHSSGMEFQDHRYWLRTHPNCIVGKELVNWLIRNGHIATRAQAIAIGQAMVDGRWLDCVSHHDQLFRDEYALYRPLQSTEFSETPSP
DSDSVNSVEGHSEPSWFKDIKFDDSDTEQIAEEGDDNLANSASPSKRTSVSSFQSTVDSDSAASISLNVELDNVNFHIKKPSKYPHVPPH
PADQKEYLISDTGGQQLSISDAFIKESLFNRRVEEKSKELPFTPLGWHHNNLELLREENGEKQAMERLLSANHNHMMALLQQLLHSDSLS
SSWRDIIVSLVCQVVQTVRPDVKNQDDDMDIRQFVHIKKDLLTRHKLLSAEFLEQHYDRFFSEYEKLLHSENYVTKRQSLKLLGELLLDR
HNFTIMTKYISKPENLKLMMNLLRDKSRNIQFEAFHVFKVFVANPNKTQPILDILLKNQAKLIEFLSKFQNDRTEDEQFNDEKTYLVKQI

--------------------------------------------------------------
>65421_65421_3_PIKFYVE-CAB39_PIKFYVE_chr2_209180097_ENST00000264380_CAB39_chr2_231674978_ENST00000410084_length(transcript)=2624nt_BP=2165nt
CAACCATGTAAGCAGCTTCGCTTCCTGCCGCAACCGTCCGCGGCCTGAGGAGCCCACCGCCGCTCTCGGGGGCCGACTTCCGGGGGCTGA
GCCGTTGAAGCGGAGGCTGGGGCGGGGGGCAGCCGGCGCGGCCGGGGCAGGAGGCGCAGACTCATGAAATGGCCACAGATGATAAGACGT
CCCCAACACTGGACTCTGCTAATGATTTGCCTCGATCTCCTACTAGTCCTTCTCATCTCACACACTTTAAACCTTTGACTCCTGATCAAG
ATGAGCCCCCTTTTAAATCAGCTTATAGTTCTTTTGTAAATCTCTTTCGTTTTAACAAAGAGAGAGCAGAAGGAGGCCAGGGAGAACAGC
AGCCTTTGAGTGGAAGTTGGACCAGCCCTCAGCTCCCTTCGAGGACACAGTCTGTTAGGTCACCCACACCTTATAAAAAGCAGCTTAATG
AGGAACTCCAGCGGCGCTCTTCAGCATTAGACACAAGAAGGAAAGCAGAACCTACCTTTGGAGGTCATGACCCTCGTACAGCTGTTCAGC
TTCGAAGCCTCAGCACAGTATTAAAACGCCTCAAGGAAATCATGGAGGGGAAAAGCCAGGATAGTGACCTGAAACAATACTGGATGCCAG
ATAGCCAATGTAAAGAGTGCTATGACTGTAGTGAGAAATTTACAACCTTTAGGCGCAGACACCATTGCCGACTATGTGGGCAGATTTTCT
GCAGTCGTTGCTGTAATCAAGAAATCCCTGGAAAATTTATGGGCTATACAGGAGACCTCCGAGCTTGCACATATTGTAGAAAAATAGCCT
TAAGTTATGCTCATTCCACAGACAGTAATTCTATTGGGGAAGACTTGAATGCTCTTTCAGATTCTGCTTGCTCTGTGTCTGTGCTTGATC
CAAGTGAACCCCGAACACCTGTTGGGAGTAGGAAAGCCAGCCGTAACATATTTTTAGAGGATGATTTGGCCTGGCAAAGTTTGATTCATC
CAGATTCCTCAAATACTCCTCTTTCAACAAGACTTGTATCTGTGCAAGAGGATGCTGGGAAATCTCCTGCTCGAAATAGATCAGCCAGCA
TTACTAACCTGTCACTGGATAGATCTGGTTCTCCTATGGTACCTTCATATGAGACATCTGTCAGTCCCCAGGCTAACCGAACATATGTTA
GGACAGAGACCACTGAGGATGAACGCAAAATTCTTCTGGACAGTGTGCAGTTAAAAGACCTGTGGAAAAAAATCTGCCATCACAGCAGTG
GAATGGAGTTTCAGGATCACCGCTACTGGTTGAGAACGCATCCCAACTGCATTGTAGGAAAGGAATTAGTCAACTGGCTAATCCGAAATG
GGCATATTGCCACAAGGGCACAAGCTATAGCAATTGGACAAGCAATGGTTGATGGACGTTGGCTGGATTGTGTTAGTCATCACGACCAGC
TTTTCAGAGATGAGTATGCGCTGTATAGACCACTGCAGAGTACAGAATTTTCTGAGACGCCTTCTCCCGACAGTGACTCAGTGAACTCCG
TGGAAGGACACTCTGAGCCATCCTGGTTTAAAGACATAAAGTTTGATGACAGTGACACAGAACAGATAGCTGAAGAAGGTGACGATAATT
TGGCTAATTCTGCCAGTCCTAGCAAGCGCACATCAGTCAGCAGTTTCCAGTCCACAGTGGACAGTGACTCAGCCGCTTCTATCAGCCTGA
ACGTGGAGCTGGACAACGTGAACTTCCATATCAAGAAGCCCTCCAAGTACCCACATGTGCCCCCTCACCCTGCTGACCAAAAAGAGTATT
TGATTTCTGACACTGGAGGACAACAGCTCTCAATAAGTGACGCTTTCATCAAAGAATCCTTATTTAATCGCCGAGTAGAGGAAAAATCCA
AAGAGCTGCCTTTCACACCTTTGGGCTGGCATCATAACAACCTGGAGCTCCTGAGGGAGGAGAATGGGGAGAAACAAGCCATGGAGAGGT
TGCTTTCAGCTAATCATAACCACATGATGGCACTACTCCAGCAGTTGCTCCATAGTGACTCACTGTCATCATCTTGGAGGGACATCATCG
TGTCATTGGTCTGCCAGGTTGTTCAGACAGTCCGACCTGATGTCAAGAACCAGGATGATGACATGGATATCCGTCAGTTTGTCCACATCA
AAAAAGATTTACTTACAAGACATAAATTGCTCAGTGCAGAATTTTTGGAACAGCATTATGATAGATTTTTCAGTGAATATGAGAAGTTAC
TTCATTCAGAAAATTATGTGACAAAAAGACAGTCACTGAAGCTTCTCGGTGAACTACTACTAGATAGACACAACTTCACAATTATGACAA
AATACATCAGTAAACCTGAGAACCTCAAATTAATGATGAACCTGCTGCGAGACAAAAGTCGCAACATCCAGTTTGAGGCCTTTCACGTTT
TTAAGGTGTTTGTAGCCAATCCTAACAAGACGCAGCCCATCCTAGACATCCTCCTCAAGAACCAGGCCAAACTCATAGAGTTCCTCAGCA
AGTTTCAGAACGACAGGACGGAGGATGAGCAGTTTAACGACGAGAAGACCTATTTAGTTAAACAGATCAGGGATTTGAAGAGACCAGCTC

>65421_65421_3_PIKFYVE-CAB39_PIKFYVE_chr2_209180097_ENST00000264380_CAB39_chr2_231674978_ENST00000410084_length(amino acids)=822AA_BP=669
MATDDKTSPTLDSANDLPRSPTSPSHLTHFKPLTPDQDEPPFKSAYSSFVNLFRFNKERAEGGQGEQQPLSGSWTSPQLPSRTQSVRSPT
PYKKQLNEELQRRSSALDTRRKAEPTFGGHDPRTAVQLRSLSTVLKRLKEIMEGKSQDSDLKQYWMPDSQCKECYDCSEKFTTFRRRHHC
RLCGQIFCSRCCNQEIPGKFMGYTGDLRACTYCRKIALSYAHSTDSNSIGEDLNALSDSACSVSVLDPSEPRTPVGSRKASRNIFLEDDL
AWQSLIHPDSSNTPLSTRLVSVQEDAGKSPARNRSASITNLSLDRSGSPMVPSYETSVSPQANRTYVRTETTEDERKILLDSVQLKDLWK
KICHHSSGMEFQDHRYWLRTHPNCIVGKELVNWLIRNGHIATRAQAIAIGQAMVDGRWLDCVSHHDQLFRDEYALYRPLQSTEFSETPSP
DSDSVNSVEGHSEPSWFKDIKFDDSDTEQIAEEGDDNLANSASPSKRTSVSSFQSTVDSDSAASISLNVELDNVNFHIKKPSKYPHVPPH
PADQKEYLISDTGGQQLSISDAFIKESLFNRRVEEKSKELPFTPLGWHHNNLELLREENGEKQAMERLLSANHNHMMALLQQLLHSDSLS
SSWRDIIVSLVCQVVQTVRPDVKNQDDDMDIRQFVHIKKDLLTRHKLLSAEFLEQHYDRFFSEYEKLLHSENYVTKRQSLKLLGELLLDR
HNFTIMTKYISKPENLKLMMNLLRDKSRNIQFEAFHVFKVFVANPNKTQPILDILLKNQAKLIEFLSKFQNDRTEDEQFNDEKTYLVKQI

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PIKFYVE-CAB39


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PIKFYVE-CAB39


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PIKFYVE-CAB39


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource