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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PIP5K1A-VPS45 (FusionGDB2 ID:65511)

Fusion Gene Summary for PIP5K1A-VPS45

check button Fusion gene summary
Fusion gene informationFusion gene name: PIP5K1A-VPS45
Fusion gene ID: 65511
HgeneTgene
Gene symbol

PIP5K1A

VPS45

Gene ID

8394

11311

Gene namephosphatidylinositol-4-phosphate 5-kinase type 1 alphavacuolar protein sorting 45 homolog
Synonyms-H1|H1VPS45|SCN5|VPS45A|VPS45B|VPS54A|VSP45|VSP45A
Cytomap

1q21.3

1q21.2

Type of geneprotein-codingprotein-coding
Descriptionphosphatidylinositol 4-phosphate 5-kinase type-1 alpha68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alphaPIP5K1-alphaPIP5KIalphaphosphatidylinositol 4-phosphate 5-kinase type I alphaptdIns(4)P-5-kinase 1 alphavacuolar protein sorting-associated protein 45leucocyte vacuolar protein sorting 45vacuolar protein sorting 45A
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000368888, ENST00000368890, 
ENST00000409426, ENST00000414290, 
ENST00000441902, ENST00000464105, 
ENST00000484306, ENST00000535106, 
ENST00000369128, ENST00000369130, 
Fusion gene scores* DoF score10 X 6 X 7=4208 X 7 X 6=336
# samples 1110
** MAII scorelog2(11/420*10)=-1.93288580414146
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/336*10)=-1.74846123300404
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PIP5K1A [Title/Abstract] AND VPS45 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPIP5K1A(151211654)-VPS45(150116886), # samples:1
Anticipated loss of major functional domain due to fusion event.PIP5K1A-VPS45 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
PIP5K1A-VPS45 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
PIP5K1A-VPS45 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePIP5K1A

GO:0008654

phospholipid biosynthetic process

15157668


check buttonFusion gene breakpoints across PIP5K1A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across VPS45 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-30-1857PIP5K1Achr1

151211654

+VPS45chr1

150116886

+


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Fusion Gene ORF analysis for PIP5K1A-VPS45

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000368888ENST00000484306PIP5K1Achr1

151211654

+VPS45chr1

150116886

+
5CDS-3UTRENST00000368888ENST00000535106PIP5K1Achr1

151211654

+VPS45chr1

150116886

+
5CDS-3UTRENST00000368890ENST00000484306PIP5K1Achr1

151211654

+VPS45chr1

150116886

+
5CDS-3UTRENST00000368890ENST00000535106PIP5K1Achr1

151211654

+VPS45chr1

150116886

+
5CDS-3UTRENST00000409426ENST00000484306PIP5K1Achr1

151211654

+VPS45chr1

150116886

+
5CDS-3UTRENST00000409426ENST00000535106PIP5K1Achr1

151211654

+VPS45chr1

150116886

+
5CDS-3UTRENST00000414290ENST00000484306PIP5K1Achr1

151211654

+VPS45chr1

150116886

+
5CDS-3UTRENST00000414290ENST00000535106PIP5K1Achr1

151211654

+VPS45chr1

150116886

+
5CDS-3UTRENST00000441902ENST00000484306PIP5K1Achr1

151211654

+VPS45chr1

150116886

+
5CDS-3UTRENST00000441902ENST00000535106PIP5K1Achr1

151211654

+VPS45chr1

150116886

+
Frame-shiftENST00000368888ENST00000369128PIP5K1Achr1

151211654

+VPS45chr1

150116886

+
Frame-shiftENST00000368890ENST00000369128PIP5K1Achr1

151211654

+VPS45chr1

150116886

+
Frame-shiftENST00000409426ENST00000369128PIP5K1Achr1

151211654

+VPS45chr1

150116886

+
Frame-shiftENST00000414290ENST00000369128PIP5K1Achr1

151211654

+VPS45chr1

150116886

+
Frame-shiftENST00000441902ENST00000369128PIP5K1Achr1

151211654

+VPS45chr1

150116886

+
In-frameENST00000368888ENST00000369130PIP5K1Achr1

151211654

+VPS45chr1

150116886

+
In-frameENST00000368890ENST00000369130PIP5K1Achr1

151211654

+VPS45chr1

150116886

+
In-frameENST00000409426ENST00000369130PIP5K1Achr1

151211654

+VPS45chr1

150116886

+
In-frameENST00000414290ENST00000369130PIP5K1Achr1

151211654

+VPS45chr1

150116886

+
In-frameENST00000441902ENST00000369130PIP5K1Achr1

151211654

+VPS45chr1

150116886

+
intron-3CDSENST00000464105ENST00000369128PIP5K1Achr1

151211654

+VPS45chr1

150116886

+
intron-3CDSENST00000464105ENST00000369130PIP5K1Achr1

151211654

+VPS45chr1

150116886

+
intron-3UTRENST00000464105ENST00000484306PIP5K1Achr1

151211654

+VPS45chr1

150116886

+
intron-3UTRENST00000464105ENST00000535106PIP5K1Achr1

151211654

+VPS45chr1

150116886

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000409426PIP5K1Achr1151211654+ENST00000369130VPS45chr1150116886+230616874031899498
ENST00000441902PIP5K1Achr1151211654+ENST00000369130VPS45chr1150116886+222116024021814470
ENST00000368890PIP5K1Achr1151211654+ENST00000369130VPS45chr1150116886+230216834021895497
ENST00000368888PIP5K1Achr1151211654+ENST00000369130VPS45chr1150116886+231917003801912510
ENST00000414290PIP5K1Achr1151211654+ENST00000369130VPS45chr1150116886+101039110603197

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000409426ENST00000369130PIP5K1Achr1151211654+VPS45chr1150116886+0.000799550.9992005
ENST00000441902ENST00000369130PIP5K1Achr1151211654+VPS45chr1150116886+0.0010612280.99893874
ENST00000368890ENST00000369130PIP5K1Achr1151211654+VPS45chr1150116886+0.0009626610.9990374
ENST00000368888ENST00000369130PIP5K1Achr1151211654+VPS45chr1150116886+0.0007549840.99924505
ENST00000414290ENST00000369130PIP5K1Achr1151211654+VPS45chr1150116886+0.021377380.9786226

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Fusion Genomic Features for PIP5K1A-VPS45


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PIP5K1Achr1151211654+VPS45chr1150116886+0.1030087840.8969912
PIP5K1Achr1151211654+VPS45chr1150116886+0.1030087840.8969912

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PIP5K1A-VPS45


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:151211654/chr1:150116886)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePIP5K1Achr1:151211654chr1:150116886ENST00000368888+111681_449426563.0DomainPIPK
HgenePIP5K1Achr1:151211654chr1:150116886ENST00000368890+101481_449413501.0DomainPIPK
HgenePIP5K1Achr1:151211654chr1:150116886ENST00000441902+91481_449386523.0DomainPIPK


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Fusion Gene Sequence for PIP5K1A-VPS45


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>65511_65511_1_PIP5K1A-VPS45_PIP5K1A_chr1_151211654_ENST00000368888_VPS45_chr1_150116886_ENST00000369130_length(transcript)=2319nt_BP=1700nt
GTGAAGCGGCCGGGTTGGGCGATTAACAGGCCGTGGTTAGGAAGGACGGAGAAGGGGCGTTCGCTCCTTTGGGACTTTTCATGCCTCGTT
TTTTTTTCAGATGTGGCTTGGTCTGGGCGCAAGGTCCCAGCAGCCAGCTTAAGCTTACTCTTCTGTGAAAGGGGAAAGTATCCCCTGTGG
AAAGCGGTTAAACTTGTGGAGGGGGTGCGGGACGTGAGTTCTTCCCCATGCCAGGCGAATGGTGTGGCCTTGAGCTGGTCCAGGAGCCGG
CTCGACGTGTCTGAGGGAGGCCCCGGAGGGGGCGGGGAGGTGGCCCACAGAACGCGGGTTCTGTAAAGAGACGTTGGGAAGATTCGATTC
CGAGAAGAGGAAGAACCGGATTGAAAGAGAGCCAGGCCGCTGAGGGGGAGGGGGCTGCTAAGATGGCGTCGGCCTCCTCCGGGCCGTCGT
CTTCGGTCGGTTTTTCATCCTTTGATCCCGCGGTCCCTTCCTGTACCTTGTCCTCAGCAGCATCTGGAATCAAGAGACCCATGGCATCTG
AGGTCTTGGAAGCTAGACAGGATTCTTACATCTCATTGGTGCCTTATGCCTCTGGCATGCCCATCAAGAAAATAGGCCATAGAAGTGTTG
ATTCCTCAGGAGAGACAACATATAAAAAGACAACCTCATCAGCCTTGAAAGGTGCCATCCAGTTAGGCATTACCCACACTGTGGGGAGCC
TGAGTACCAAACCAGAGCGTGATGTCCTCATGCAAGATTTCTACGTGGTTGAGAGTATCTTCTTTCCCAGTGAAGGGAGCAACCTGACCC
CTGCTCATCACTACAATGACTTTCGTTTCAAGACCTATGCACCTGTTGCCTTCCGCTACTTCCGGGAGCTATTTGGTATCCGGCCCGATG
ATTACTTGTATTCCCTCTGCAGTGAGCCGCTGATTGAACTCTGTAGCTCTGGAGCTAGTGGTTCCCTATTCTATGTGTCCAGCGACGATG
AGTTCATTATTAAGACAGTCCAACATAAAGAGGCGGAATTTCTGCAGAAGCTGCTTCCAGGATACTACATGAACCTCAACCAGAACCCTC
GGACTTTGCTGCCTAAATTCTATGGACTGTACTGTGTGCAGGCAGGTGGCAAGAACATTCGGATTGTGGTGATGAACAATCTTTTACCAA
GATCGGTAAAAATGCATATCAAATATGACCTCAAAGGCTCAACCTACAAACGGCGGGCTTCCCAGAAAGAGCGAGAGAAGCCTCTTCCCA
CATTTAAAGACCTAGACTTCTTACAAGACATCCCTGATGGTCTTTTTTTGGATGCTGACATGTACAACGCTCTCTGTAAGACCCTGCAGC
GTGACTGTTTGGTGCTGCAGAGCTTCAAGATAATGGATTACAGCCTCTTGATGTCAATCCATAATATAGATCATGCACAACGAGAGCCCT
TAAGCAGTGAAACACAGTACTCAGTTGATACTCGAAGACCGGCCCCCCAAAAGGCTCTGTATTCCACAGCCATGGAATCCATCCAGGGAG
AGGCTCGACGGGGTGGTACCATGGAGACTGATGACCATATGGGTGGCATCCCTGCCCGGAATAGTAAAGGGGAAAGGCTTCTGCTTTATA
TTGGCATCATTGACATTCTACAGTCTTACAGGTTTGTTAAGAAGTTGGAGCACTCTTGGAAAGCCCTGGTACATGACGGATTTCCTAGAG
GAAGTTCTGGCTTCTGGACTGCACAGCCGAAGCAAGGAGAGCTCTCAAGTCACATCAAGGTCAGCGAGCAGAAGATGAAACGGTGGTTGG
GGGAAGGGCACAGCTTCCTCTCTTGTCCCCACTACAGGTTTTCCCTACTAAACAAAGGTGTTGGAGAGCAGCTTTGGGTTCTGTGCTGGT
TGTTAGAACTCATCTCCAGGTAGCCCACGGATACGTGGTTGGCACAGACACAAGACTCCCAGAGTTGTCCTAACAATAAGTCTGAGCCCA
TCTCAACCCACTTTTCTCCGGTAGTCTTTATGTATCTGTTAGCACAATCACTTCAGTTACTGATGAATTTTGTTGGGATCTGACTTGGGG
AAAGGGTTATCAGAGCCTAGAGGGGCTTAAAAAGTAATCATTTGATGTACATACCACACTCCTTGGCTTCCTTTCTCTTCCCTTAACCCT
TTCTGCTTTTCATTAACCACATTCCTGCACAACTCATTTCTGAAAACCTACCATGTTTCTTTACAGAGCCATCCAAAAATTTTTTGTCCC

>65511_65511_1_PIP5K1A-VPS45_PIP5K1A_chr1_151211654_ENST00000368888_VPS45_chr1_150116886_ENST00000369130_length(amino acids)=510AA_BP=440
MKESQAAEGEGAAKMASASSGPSSSVGFSSFDPAVPSCTLSSAASGIKRPMASEVLEARQDSYISLVPYASGMPIKKIGHRSVDSSGETT
YKKTTSSALKGAIQLGITHTVGSLSTKPERDVLMQDFYVVESIFFPSEGSNLTPAHHYNDFRFKTYAPVAFRYFRELFGIRPDDYLYSLC
SEPLIELCSSGASGSLFYVSSDDEFIIKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQAGGKNIRIVVMNNLLPRSVKMHI
KYDLKGSTYKRRASQKEREKPLPTFKDLDFLQDIPDGLFLDADMYNALCKTLQRDCLVLQSFKIMDYSLLMSIHNIDHAQREPLSSETQY
SVDTRRPAPQKALYSTAMESIQGEARRGGTMETDDHMGGIPARNSKGERLLLYIGIIDILQSYRFVKKLEHSWKALVHDGFPRGSSGFWT

--------------------------------------------------------------
>65511_65511_2_PIP5K1A-VPS45_PIP5K1A_chr1_151211654_ENST00000368890_VPS45_chr1_150116886_ENST00000369130_length(transcript)=2302nt_BP=1683nt
ATTTTTTGCTTGGCTACCCGGAGTGAAGCGGCCGGGTTGGGCGATTAACAGGCCGTGGTTAGGAAGGACGGAGAAGGGGCGTTCGCTCCT
TTGGGACTTTTCATGCCTCGTTTTTTTTTCAGATGTGGCTTGGTCTGGGCGCAAGGTCCCAGCAGCCAGCTTAAGCTTACTCTTCTGTGA
AAGGGGAAAGTATCCCCTGTGGAAAGCGGTTAAACTTGTGGAGGGGGTGCGGGACGTGAGTTCTTCCCCATGCCAGGCGAATGGTGTGGC
CTTGAGCTGGTCCAGGAGCCGGCTCGACGTGTCTGAGGGAGGCCCCGGAGGGGGCGGGGAGGTGGCCCACAGAACGCGGGTTCTGTAAAG
AGACGTTGGGAAGATTCGATTCCGAGAAGAGGAAGAACCGGATTGAAAGAGAGCCAGGCCGCTGAGGGGGAGGGGGCTGCTAAGATGGCG
TCGGCCTCCTCCGGGCCGTCGTCTTCGGTCGGTTTTTCATCCTTTGATCCCGCGGTCCCTTCCTGTACCTTGTCCTCAGCATCTGGAATC
AAGAGACCCATGGCATCTGAGGTGCCTTATGCCTCTGGCATGCCCATCAAGAAAATAGGCCATAGAAGTGTTGATTCCTCAGGAGAGACA
ACATATAAAAAGACAACCTCATCAGCCTTGAAAGGTGCCATCCAGTTAGGCATTACCCACACTGTGGGGAGCCTGAGTACCAAACCAGAG
CGTGATGTCCTCATGCAAGATTTCTACGTGGTTGAGAGTATCTTCTTTCCCAGTGAAGGGAGCAACCTGACCCCTGCTCATCACTACAAT
GACTTTCGTTTCAAGACCTATGCACCTGTTGCCTTCCGCTACTTCCGGGAGCTATTTGGTATCCGGCCCGATGATTACTTGTATTCCCTC
TGCAGTGAGCCGCTGATTGAACTCTGTAGCTCTGGAGCTAGTGGTTCCCTATTCTATGTGTCCAGCGACGATGAGTTCATTATTAAGACA
GTCCAACATAAAGAGGCGGAATTTCTGCAGAAGCTGCTTCCAGGATACTACATGAACCTCAACCAGAACCCTCGGACTTTGCTGCCTAAA
TTCTATGGACTGTACTGTGTGCAGGCAGGTGGCAAGAACATTCGGATTGTGGTGATGAACAATCTTTTACCAAGATCGGTAAAAATGCAT
ATCAAATATGACCTCAAAGGCTCAACCTACAAACGGCGGGCTTCCCAGAAAGAGCGAGAGAAGCCTCTTCCCACATTTAAAGACCTAGAC
TTCTTACAAGACATCCCTGATGGTCTTTTTTTGGATGCTGACATGTACAACGCTCTCTGTAAGACCCTGCAGCGTGACTGTTTGGTGCTG
CAGAGCTTCAAGATAATGGATTACAGCCTCTTGATGTCAATCCATAATATAGATCATGCACAACGAGAGCCCTTAAGCAGTGAAACACAG
TACTCAGTTGATACTCGAAGACCGGCCCCCCAAAAGGCTCTGTATTCCACAGCCATGGAATCCATCCAGGGAGAGGCTCGACGGGGTGGT
ACCATGGAGACTGATGACCATATGGGTGGCATCCCTGCCCGGAATAGTAAAGGGGAAAGGCTTCTGCTTTATATTGGCATCATTGACATT
CTACAGTCTTACAGGTTTGTTAAGAAGTTGGAGCACTCTTGGAAAGCCCTGGTACATGACGGATTTCCTAGAGGAAGTTCTGGCTTCTGG
ACTGCACAGCCGAAGCAAGGAGAGCTCTCAAGTCACATCAAGGTCAGCGAGCAGAAGATGAAACGGTGGTTGGGGGAAGGGCACAGCTTC
CTCTCTTGTCCCCACTACAGGTTTTCCCTACTAAACAAAGGTGTTGGAGAGCAGCTTTGGGTTCTGTGCTGGTTGTTAGAACTCATCTCC
AGGTAGCCCACGGATACGTGGTTGGCACAGACACAAGACTCCCAGAGTTGTCCTAACAATAAGTCTGAGCCCATCTCAACCCACTTTTCT
CCGGTAGTCTTTATGTATCTGTTAGCACAATCACTTCAGTTACTGATGAATTTTGTTGGGATCTGACTTGGGGAAAGGGTTATCAGAGCC
TAGAGGGGCTTAAAAAGTAATCATTTGATGTACATACCACACTCCTTGGCTTCCTTTCTCTTCCCTTAACCCTTTCTGCTTTTCATTAAC
CACATTCCTGCACAACTCATTTCTGAAAACCTACCATGTTTCTTTACAGAGCCATCCAAAAATTTTTTGTCCCTACATAGCAATTTTCTG

>65511_65511_2_PIP5K1A-VPS45_PIP5K1A_chr1_151211654_ENST00000368890_VPS45_chr1_150116886_ENST00000369130_length(amino acids)=497AA_BP=427
MKESQAAEGEGAAKMASASSGPSSSVGFSSFDPAVPSCTLSSASGIKRPMASEVPYASGMPIKKIGHRSVDSSGETTYKKTTSSALKGAI
QLGITHTVGSLSTKPERDVLMQDFYVVESIFFPSEGSNLTPAHHYNDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCSEPLIELCSSGAS
GSLFYVSSDDEFIIKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQAGGKNIRIVVMNNLLPRSVKMHIKYDLKGSTYKRRA
SQKEREKPLPTFKDLDFLQDIPDGLFLDADMYNALCKTLQRDCLVLQSFKIMDYSLLMSIHNIDHAQREPLSSETQYSVDTRRPAPQKAL
YSTAMESIQGEARRGGTMETDDHMGGIPARNSKGERLLLYIGIIDILQSYRFVKKLEHSWKALVHDGFPRGSSGFWTAQPKQGELSSHIK

--------------------------------------------------------------
>65511_65511_3_PIP5K1A-VPS45_PIP5K1A_chr1_151211654_ENST00000409426_VPS45_chr1_150116886_ENST00000369130_length(transcript)=2306nt_BP=1687nt
GATTTTTTGCTTGGCTACCCGGAGTGAAGCGGCCGGGTTGGGCGATTAACAGGCCGTGGTTAGGAAGGACGGAGAAGGGGCGTTCGCTCC
TTTGGGACTTTTCATGCCTCGTTTTTTTTTCAGATGTGGCTTGGTCTGGGCGCAAGGTCCCAGCAGCCAGCTTAAGCTTACTCTTCTGTG
AAAGGGGAAAGTATCCCCTGTGGAAAGCGGTTAAACTTGTGGAGGGGGTGCGGGACGTGAGTTCTTCCCCATGCCAGGCGAATGGTGTGG
CCTTGAGCTGGTCCAGGAGCCGGCTCGACGTGTCTGAGGGAGGCCCCGGAGGGGGCGGGGAGGTGGCCCACAGAACGCGGGTTCTGTAAA
GAGACGTTGGGAAGATTCGATTCCGAGAAGAGGAAGAACCGGATTGAAAGAGAGCCAGGCCGCTGAGGGGGAGGGGGCTGCTAAGATGGC
GTCGGCCTCCTCCGGGCCGTCGTCTTCGGTCGGTTTTTCATCCTTTGATCCCGCGGTCCCTTCCTGTACCTTGTCCTCAGCAGCATCTGG
AATCAAGAGACCCATGGCATCTGAGGTGCCTTATGCCTCTGGCATGCCCATCAAGAAAATAGGCCATAGAAGTGTTGATTCCTCAGGAGA
GACAACATATAAAAAGACAACCTCATCAGCCTTGAAAGGTGCCATCCAGTTAGGCATTACCCACACTGTGGGGAGCCTGAGTACCAAACC
AGAGCGTGATGTCCTCATGCAAGATTTCTACGTGGTTGAGAGTATCTTCTTTCCCAGTGAAGGGAGCAACCTGACCCCTGCTCATCACTA
CAATGACTTTCGTTTCAAGACCTATGCACCTGTTGCCTTCCGCTACTTCCGGGAGCTATTTGGTATCCGGCCCGATGATTACTTGTATTC
CCTCTGCAGTGAGCCGCTGATTGAACTCTGTAGCTCTGGAGCTAGTGGTTCCCTATTCTATGTGTCCAGCGACGATGAGTTCATTATTAA
GACAGTCCAACATAAAGAGGCGGAATTTCTGCAGAAGCTGCTTCCAGGATACTACATGAACCTCAACCAGAACCCTCGGACTTTGCTGCC
TAAATTCTATGGACTGTACTGTGTGCAGGCAGGTGGCAAGAACATTCGGATTGTGGTGATGAACAATCTTTTACCAAGATCGGTAAAAAT
GCATATCAAATATGACCTCAAAGGCTCAACCTACAAACGGCGGGCTTCCCAGAAAGAGCGAGAGAAGCCTCTTCCCACATTTAAAGACCT
AGACTTCTTACAAGACATCCCTGATGGTCTTTTTTTGGATGCTGACATGTACAACGCTCTCTGTAAGACCCTGCAGCGTGACTGTTTGGT
GCTGCAGAGCTTCAAGATAATGGATTACAGCCTCTTGATGTCAATCCATAATATAGATCATGCACAACGAGAGCCCTTAAGCAGTGAAAC
ACAGTACTCAGTTGATACTCGAAGACCGGCCCCCCAAAAGGCTCTGTATTCCACAGCCATGGAATCCATCCAGGGAGAGGCTCGACGGGG
TGGTACCATGGAGACTGATGACCATATGGGTGGCATCCCTGCCCGGAATAGTAAAGGGGAAAGGCTTCTGCTTTATATTGGCATCATTGA
CATTCTACAGTCTTACAGGTTTGTTAAGAAGTTGGAGCACTCTTGGAAAGCCCTGGTACATGACGGATTTCCTAGAGGAAGTTCTGGCTT
CTGGACTGCACAGCCGAAGCAAGGAGAGCTCTCAAGTCACATCAAGGTCAGCGAGCAGAAGATGAAACGGTGGTTGGGGGAAGGGCACAG
CTTCCTCTCTTGTCCCCACTACAGGTTTTCCCTACTAAACAAAGGTGTTGGAGAGCAGCTTTGGGTTCTGTGCTGGTTGTTAGAACTCAT
CTCCAGGTAGCCCACGGATACGTGGTTGGCACAGACACAAGACTCCCAGAGTTGTCCTAACAATAAGTCTGAGCCCATCTCAACCCACTT
TTCTCCGGTAGTCTTTATGTATCTGTTAGCACAATCACTTCAGTTACTGATGAATTTTGTTGGGATCTGACTTGGGGAAAGGGTTATCAG
AGCCTAGAGGGGCTTAAAAAGTAATCATTTGATGTACATACCACACTCCTTGGCTTCCTTTCTCTTCCCTTAACCCTTTCTGCTTTTCAT
TAACCACATTCCTGCACAACTCATTTCTGAAAACCTACCATGTTTCTTTACAGAGCCATCCAAAAATTTTTTGTCCCTACATAGCAATTT

>65511_65511_3_PIP5K1A-VPS45_PIP5K1A_chr1_151211654_ENST00000409426_VPS45_chr1_150116886_ENST00000369130_length(amino acids)=498AA_BP=428
MKESQAAEGEGAAKMASASSGPSSSVGFSSFDPAVPSCTLSSAASGIKRPMASEVPYASGMPIKKIGHRSVDSSGETTYKKTTSSALKGA
IQLGITHTVGSLSTKPERDVLMQDFYVVESIFFPSEGSNLTPAHHYNDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCSEPLIELCSSGA
SGSLFYVSSDDEFIIKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQAGGKNIRIVVMNNLLPRSVKMHIKYDLKGSTYKRR
ASQKEREKPLPTFKDLDFLQDIPDGLFLDADMYNALCKTLQRDCLVLQSFKIMDYSLLMSIHNIDHAQREPLSSETQYSVDTRRPAPQKA
LYSTAMESIQGEARRGGTMETDDHMGGIPARNSKGERLLLYIGIIDILQSYRFVKKLEHSWKALVHDGFPRGSSGFWTAQPKQGELSSHI

--------------------------------------------------------------
>65511_65511_4_PIP5K1A-VPS45_PIP5K1A_chr1_151211654_ENST00000414290_VPS45_chr1_150116886_ENST00000369130_length(transcript)=1010nt_BP=391nt
GGATGCTGACATGTACAACGCTCTCTGTAAGACCCTGCAGCGTGACTGTTTGGTGCTGCAGAGCTTCAAGATAATGGATTACAGCCTCTT
GATGTCAATCCATAATATAGATCATGCACAACGAGAGCCCTTAAGCAGTGAAACACAGTACTCAGTTGATACTCGAAGACCGGCCCCCCA
AAAGGCTCTGTATTCCACAGCCATGGAATCCATCCAGGGAGAGGCTCGACGGGGTGGTACCATGGAGACTGATGACCATATGGGTGGCAT
CCCTGCCCGGAATAGTAAAGGGGAAAGGCTTCTGCTTTATATTGGCATCATTGACATTCTACAGTCTTACAGGTTTGTTAAGAAGTTGGA
GCACTCTTGGAAAGCCCTGGTACATGACGGATTTCCTAGAGGAAGTTCTGGCTTCTGGACTGCACAGCCGAAGCAAGGAGAGCTCTCAAG
TCACATCAAGGTCAGCGAGCAGAAGATGAAACGGTGGTTGGGGGAAGGGCACAGCTTCCTCTCTTGTCCCCACTACAGGTTTTCCCTACT
AAACAAAGGTGTTGGAGAGCAGCTTTGGGTTCTGTGCTGGTTGTTAGAACTCATCTCCAGGTAGCCCACGGATACGTGGTTGGCACAGAC
ACAAGACTCCCAGAGTTGTCCTAACAATAAGTCTGAGCCCATCTCAACCCACTTTTCTCCGGTAGTCTTTATGTATCTGTTAGCACAATC
ACTTCAGTTACTGATGAATTTTGTTGGGATCTGACTTGGGGAAAGGGTTATCAGAGCCTAGAGGGGCTTAAAAAGTAATCATTTGATGTA
CATACCACACTCCTTGGCTTCCTTTCTCTTCCCTTAACCCTTTCTGCTTTTCATTAACCACATTCCTGCACAACTCATTTCTGAAAACCT
ACCATGTTTCTTTACAGAGCCATCCAAAAATTTTTTGTCCCTACATAGCAATTTTCTGTGGCACTGAGAAACCATGTATGACCACAATAA

>65511_65511_4_PIP5K1A-VPS45_PIP5K1A_chr1_151211654_ENST00000414290_VPS45_chr1_150116886_ENST00000369130_length(amino acids)=197AA_BP=127
MYNALCKTLQRDCLVLQSFKIMDYSLLMSIHNIDHAQREPLSSETQYSVDTRRPAPQKALYSTAMESIQGEARRGGTMETDDHMGGIPAR
NSKGERLLLYIGIIDILQSYRFVKKLEHSWKALVHDGFPRGSSGFWTAQPKQGELSSHIKVSEQKMKRWLGEGHSFLSCPHYRFSLLNKG

--------------------------------------------------------------
>65511_65511_5_PIP5K1A-VPS45_PIP5K1A_chr1_151211654_ENST00000441902_VPS45_chr1_150116886_ENST00000369130_length(transcript)=2221nt_BP=1602nt
ATTTTTTGCTTGGCTACCCGGAGTGAAGCGGCCGGGTTGGGCGATTAACAGGCCGTGGTTAGGAAGGACGGAGAAGGGGCGTTCGCTCCT
TTGGGACTTTTCATGCCTCGTTTTTTTTTCAGATGTGGCTTGGTCTGGGCGCAAGGTCCCAGCAGCCAGCTTAAGCTTACTCTTCTGTGA
AAGGGGAAAGTATCCCCTGTGGAAAGCGGTTAAACTTGTGGAGGGGGTGCGGGACGTGAGTTCTTCCCCATGCCAGGCGAATGGTGTGGC
CTTGAGCTGGTCCAGGAGCCGGCTCGACGTGTCTGAGGGAGGCCCCGGAGGGGGCGGGGAGGTGGCCCACAGAACGCGGGTTCTGTAAAG
AGACGTTGGGAAGATTCGATTCCGAGAAGAGGAAGAACCGGATTGAAAGAGAGCCAGGCCGCTGAGGGGGAGGGGGCTGCTAAGATGGCG
TCGGCCTCCTCCGGGCCGTCGTCTTCGGTCGGTTTTTCATCCTTTGATCCCGCGGTCCCTTCCTGTACCTTGTCCTCAGCAGCATCTGGA
ATCAAGAGACCCATGGCATCTGAGGTGCCTTATGCCTCTGGCATGCCCATCAAGAAAATAGGCCATAGAAGTGTTGATTCCTCAGGAGAG
ACAACATATAAAAAGACAACCTCATCAGCCTTGAAAGGTGCCATCCAGTTAGGCATTACCCACACTGTGGGGAGCCTGAGTACCAAACCA
GAGCGTGATGTCCTCATGCAAGATTTCTACGTGGTTGAGAGTATCTTCTTTCCCAGTGAAGGGAGCAACCTGACCCCTGCTCATCACTAC
AATGACTTTCGTTTCAAGACCTATGCACCTGTTGCCTTCCGCTACTTCCGGGAGCTATTTGGTATCCGGCCCGATGATTACTTGTATTCC
CTCTGCAGTGAGCCGCTGATTGAACTCTGTAGCTCTGGAGCTAGTGGTTCCCTATTCTATGTGTCCAGCGACGATGAGTTCATTATTAAG
ACAGTCCAACATAAAGAGGCGGAATTTCTGCAGAAGCTGCTTCCAGGATACTACATGAACCTCAACCAGAACCCTCGGACTTTGCTGCCT
AAATTCTATGGACTGTACTGTGTGCAGGCAGGTGGCAAGAACATTCGGATTGTGGTGATGAACAATCTTTTACCAAGATCGGTAAAAATG
CATATCAAATATGACCTCAAAGGCTCAACCTACAAACGGCGGGCTTCCCAGAAAGAGCGAGAGAAGCCTCTTCCCACATTTAAAGACCTA
GACTTCTTACAAGACATCCCTGATGGTCTTTTTTTGGATGCTGACATGTACAACGCTCTCTGTAAGACCCTGCAGCGTGACTGTTTGGTG
CTGCAGAGCTTCAAGATAATGGATTACAGCCTCTTGATGTCAATCCATAATATAGATCATGCACAACGAGAGCCCTTAAGCAGTGAAACA
CAGTACTCAGTTGATACTCGAAGACCGGCCCCCCAAAAGGCTCTGTATTCCACAGCCATGGAATCCATCCAGGGAGAGGCTCGACGGGGT
GGTACCATGGAGACTGATGACCAGTTTGTTAAGAAGTTGGAGCACTCTTGGAAAGCCCTGGTACATGACGGATTTCCTAGAGGAAGTTCT
GGCTTCTGGACTGCACAGCCGAAGCAAGGAGAGCTCTCAAGTCACATCAAGGTCAGCGAGCAGAAGATGAAACGGTGGTTGGGGGAAGGG
CACAGCTTCCTCTCTTGTCCCCACTACAGGTTTTCCCTACTAAACAAAGGTGTTGGAGAGCAGCTTTGGGTTCTGTGCTGGTTGTTAGAA
CTCATCTCCAGGTAGCCCACGGATACGTGGTTGGCACAGACACAAGACTCCCAGAGTTGTCCTAACAATAAGTCTGAGCCCATCTCAACC
CACTTTTCTCCGGTAGTCTTTATGTATCTGTTAGCACAATCACTTCAGTTACTGATGAATTTTGTTGGGATCTGACTTGGGGAAAGGGTT
ATCAGAGCCTAGAGGGGCTTAAAAAGTAATCATTTGATGTACATACCACACTCCTTGGCTTCCTTTCTCTTCCCTTAACCCTTTCTGCTT
TTCATTAACCACATTCCTGCACAACTCATTTCTGAAAACCTACCATGTTTCTTTACAGAGCCATCCAAAAATTTTTTGTCCCTACATAGC

>65511_65511_5_PIP5K1A-VPS45_PIP5K1A_chr1_151211654_ENST00000441902_VPS45_chr1_150116886_ENST00000369130_length(amino acids)=470AA_BP=400
MKESQAAEGEGAAKMASASSGPSSSVGFSSFDPAVPSCTLSSAASGIKRPMASEVPYASGMPIKKIGHRSVDSSGETTYKKTTSSALKGA
IQLGITHTVGSLSTKPERDVLMQDFYVVESIFFPSEGSNLTPAHHYNDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCSEPLIELCSSGA
SGSLFYVSSDDEFIIKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQAGGKNIRIVVMNNLLPRSVKMHIKYDLKGSTYKRR
ASQKEREKPLPTFKDLDFLQDIPDGLFLDADMYNALCKTLQRDCLVLQSFKIMDYSLLMSIHNIDHAQREPLSSETQYSVDTRRPAPQKA
LYSTAMESIQGEARRGGTMETDDQFVKKLEHSWKALVHDGFPRGSSGFWTAQPKQGELSSHIKVSEQKMKRWLGEGHSFLSCPHYRFSLL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PIP5K1A-VPS45


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PIP5K1A-VPS45


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PIP5K1A-VPS45


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource