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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARL15-ASCC3 (FusionGDB2 ID:6558)

Fusion Gene Summary for ARL15-ASCC3

check button Fusion gene summary
Fusion gene informationFusion gene name: ARL15-ASCC3
Fusion gene ID: 6558
HgeneTgene
Gene symbol

ARL15

ASCC3

Gene ID

54622

10973

Gene nameADP ribosylation factor like GTPase 15activating signal cointegrator 1 complex subunit 3
SynonymsARFRP2ASC1p200|HELIC1|RNAH
Cytomap

5q11.2

6q16.3

Type of geneprotein-codingprotein-coding
DescriptionADP-ribosylation factor-like protein 15ADP-ribosylation factor-like 15ADP-ribosylation factor-related protein 2ARF-related protein 2activating signal cointegrator 1 complex subunit 3ASC-1 complex subunit P200RNA helicase familyhelicase, ATP binding 1trip4 complex subunit p200
Modification date2020031320200313
UniProtAcc

Q9NXU5

Q8N3C0

Ensembl transtripts involved in fusion geneENST00000504924, ENST00000507646, 
ENST00000502271, ENST00000510591, 
ENST00000369143, ENST00000522650, 
ENST00000369162, 
Fusion gene scores* DoF score18 X 13 X 7=163814 X 10 X 11=1540
# samples 1818
** MAII scorelog2(18/1638*10)=-3.18586654531133
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/1540*10)=-3.09686153925259
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARL15 [Title/Abstract] AND ASCC3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARL15(53409032)-ASCC3(101054966), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneASCC3

GO:0006307

DNA dealkylation involved in DNA repair

22055184

TgeneASCC3

GO:0032508

DNA duplex unwinding

22055184


check buttonFusion gene breakpoints across ARL15 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ASCC3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ADA153697ARL15chr5

53409032

-ASCC3chr6

101054966

-


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Fusion Gene ORF analysis for ARL15-ASCC3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000504924ENST00000369143ARL15chr5

53409032

-ASCC3chr6

101054966

-
5CDS-intronENST00000504924ENST00000522650ARL15chr5

53409032

-ASCC3chr6

101054966

-
5CDS-intronENST00000507646ENST00000369143ARL15chr5

53409032

-ASCC3chr6

101054966

-
5CDS-intronENST00000507646ENST00000522650ARL15chr5

53409032

-ASCC3chr6

101054966

-
5UTR-3CDSENST00000502271ENST00000369162ARL15chr5

53409032

-ASCC3chr6

101054966

-
5UTR-3CDSENST00000510591ENST00000369162ARL15chr5

53409032

-ASCC3chr6

101054966

-
5UTR-intronENST00000502271ENST00000369143ARL15chr5

53409032

-ASCC3chr6

101054966

-
5UTR-intronENST00000502271ENST00000522650ARL15chr5

53409032

-ASCC3chr6

101054966

-
5UTR-intronENST00000510591ENST00000369143ARL15chr5

53409032

-ASCC3chr6

101054966

-
5UTR-intronENST00000510591ENST00000522650ARL15chr5

53409032

-ASCC3chr6

101054966

-
In-frameENST00000504924ENST00000369162ARL15chr5

53409032

-ASCC3chr6

101054966

-
In-frameENST00000507646ENST00000369162ARL15chr5

53409032

-ASCC3chr6

101054966

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000504924ARL15chr553409032-ENST00000369162ASCC3chr6101054966-357255612379792
ENST00000507646ARL15chr553409032-ENST00000369162ASCC3chr6101054966-357555912382793

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000504924ENST00000369162ARL15chr553409032-ASCC3chr6101054966-0.0003378430.99966216
ENST00000507646ENST00000369162ARL15chr553409032-ASCC3chr6101054966-0.0003374290.9996625

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Fusion Genomic Features for ARL15-ASCC3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ARL15-ASCC3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:53409032/chr6:101054966)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARL15

Q9NXU5

ASCC3

Q8N3C0

FUNCTION: 3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions (PubMed:22055184). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347). {ECO:0000269|PubMed:12077347, ECO:0000269|PubMed:22055184}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARL15chr5:53409032chr6:101054966ENST00000504924-45142_145154205.0Nucleotide bindingGTP
HgeneARL15chr5:53409032chr6:101054966ENST00000504924-4539_46154205.0Nucleotide bindingGTP
HgeneARL15chr5:53409032chr6:101054966ENST00000504924-4582_86154205.0Nucleotide bindingGTP
TgeneASCC3chr5:53409032chr6:101054966ENST000003691430418_790112.0Coiled coilOntology_term=ECO:0000255
TgeneASCC3chr5:53409032chr6:101054966ENST0000036914304328_3560112.0Coiled coilOntology_term=ECO:0000255
TgeneASCC3chr5:53409032chr6:101054966ENST0000052265001318_790732.0Coiled coilOntology_term=ECO:0000255
TgeneASCC3chr5:53409032chr6:101054966ENST00000522650013328_3560732.0Coiled coilOntology_term=ECO:0000255
TgeneASCC3chr5:53409032chr6:101054966ENST00000369143041336_15110112.0DomainHelicase ATP-binding 2
TgeneASCC3chr5:53409032chr6:101054966ENST00000369143041544_17390112.0DomainHelicase C-terminal 2
TgeneASCC3chr5:53409032chr6:101054966ENST00000369143041812_21760112.0DomainNote=SEC63 2
TgeneASCC3chr5:53409032chr6:101054966ENST0000036914304486_6690112.0DomainHelicase ATP-binding 1
TgeneASCC3chr5:53409032chr6:101054966ENST0000036914304728_9140112.0DomainHelicase C-terminal 1
TgeneASCC3chr5:53409032chr6:101054966ENST0000036914304978_12870112.0DomainNote=SEC63 1
TgeneASCC3chr5:53409032chr6:101054966ENST0000036916229421812_217615952203.0DomainNote=SEC63 2
TgeneASCC3chr5:53409032chr6:101054966ENST000005226500131336_15110732.0DomainHelicase ATP-binding 2
TgeneASCC3chr5:53409032chr6:101054966ENST000005226500131544_17390732.0DomainHelicase C-terminal 2
TgeneASCC3chr5:53409032chr6:101054966ENST000005226500131812_21760732.0DomainNote=SEC63 2
TgeneASCC3chr5:53409032chr6:101054966ENST00000522650013486_6690732.0DomainHelicase ATP-binding 1
TgeneASCC3chr5:53409032chr6:101054966ENST00000522650013728_9140732.0DomainHelicase C-terminal 1
TgeneASCC3chr5:53409032chr6:101054966ENST00000522650013978_12870732.0DomainNote=SEC63 1
TgeneASCC3chr5:53409032chr6:101054966ENST00000369143041453_14560112.0MotifNote=DEIH box
TgeneASCC3chr5:53409032chr6:101054966ENST0000036914304611_6140112.0MotifNote=DEVH box
TgeneASCC3chr5:53409032chr6:101054966ENST000005226500131453_14560732.0MotifNote=DEIH box
TgeneASCC3chr5:53409032chr6:101054966ENST00000522650013611_6140732.0MotifNote=DEVH box
TgeneASCC3chr5:53409032chr6:101054966ENST00000369143041349_13560112.0Nucleotide bindingATP
TgeneASCC3chr5:53409032chr6:101054966ENST0000036914304499_5060112.0Nucleotide bindingATP
TgeneASCC3chr5:53409032chr6:101054966ENST000005226500131349_13560732.0Nucleotide bindingATP
TgeneASCC3chr5:53409032chr6:101054966ENST00000522650013499_5060732.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneASCC3chr5:53409032chr6:101054966ENST00000369162294218_7915952203.0Coiled coilOntology_term=ECO:0000255
TgeneASCC3chr5:53409032chr6:101054966ENST000003691622942328_35615952203.0Coiled coilOntology_term=ECO:0000255
TgeneASCC3chr5:53409032chr6:101054966ENST0000036916229421336_151115952203.0DomainHelicase ATP-binding 2
TgeneASCC3chr5:53409032chr6:101054966ENST0000036916229421544_173915952203.0DomainHelicase C-terminal 2
TgeneASCC3chr5:53409032chr6:101054966ENST000003691622942486_66915952203.0DomainHelicase ATP-binding 1
TgeneASCC3chr5:53409032chr6:101054966ENST000003691622942728_91415952203.0DomainHelicase C-terminal 1
TgeneASCC3chr5:53409032chr6:101054966ENST000003691622942978_128715952203.0DomainNote=SEC63 1
TgeneASCC3chr5:53409032chr6:101054966ENST0000036916229421453_145615952203.0MotifNote=DEIH box
TgeneASCC3chr5:53409032chr6:101054966ENST000003691622942611_61415952203.0MotifNote=DEVH box
TgeneASCC3chr5:53409032chr6:101054966ENST0000036916229421349_135615952203.0Nucleotide bindingATP
TgeneASCC3chr5:53409032chr6:101054966ENST000003691622942499_50615952203.0Nucleotide bindingATP


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Fusion Gene Sequence for ARL15-ASCC3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>6558_6558_1_ARL15-ASCC3_ARL15_chr5_53409032_ENST00000504924_ASCC3_chr6_101054966_ENST00000369162_length(transcript)=3572nt_BP=556nt
GTTGCTGGCTTTTTCAGGAGCTGCTCGCTCGCAGCCAGAGACGCTGCTTTTTTTTTCCGGGTTCGGAGCCGTTCCGGATGCTTTAGGCTG
CCGGATGTCTGATCTCCGAATAACTGAGGCGTTTCTGTACATGGATTATCTGTGTTTTAGAGCACTTTGCTGCAAGGGACCACCACCTGC
ACGACCAGAATATGACCTGGTTTGCATAGGCCTCACAGGTTCTGGCAAAACCAGTCTGTTGTCCAAACTCTGCAGTGAAAGCCCCGATAA
CGTCGTGTCGACCACAGGTTTTAGTATTAAAGCAGTGCCATTCCAGAATGCCATCTTGAATGTAAAAGAACTTGGAGGGGCTGATAACAT
CCGGAAATACTGGAGCCGCTACTACCAAGGATCTCAAGGGGTAATATTTGTATTAGACAGTGCCTCTTCAGAGGATGATTTAGAAGCTGC
TAGAAATGAGCTGCACTCAGCTCTTCAGCATCCACAGTTATGCACTTTACCCTTTTTAATATTGGCCAATCATCAAGACAAGCCAGCAGC
TCGCTCAGTACAAGAGATGGAGAACATCATTGCAACAGTAAGAGATTCCAACCTCAAGCTGACCCTTGCTTTCGGGATAGGAATGCATCA
TGCTGGACTACATGAGAGGGACCGAAAAACAGTAGAGGAACTATTTGTAAACTGTAAAGTTCAGGTTCTTATTGCTACAAGCACATTAGC
CTGGGGTGTAAACTTTCCAGCTCATTTAGTAATTATTAAGGGAACAGAATACTATGATGGAAAAACAAGACGTTATGTGGATTTTCCCAT
TACAGATGTCCTCCAGATGATGGGGCGTGCTGGGAGGCCGCAGTTCGATGACCAAGGCAAAGCTGTAATTCTAGTTCATGACATAAAGAA
AGACTTTTATAAAAAATTTCTTTATGAACCTTTCCCAGTAGAATCAAGTTTATTAGGAGTGCTCTCTGACCACTTAAATGCAGAGATTGC
TGGTGGTACAATTACATCTAAGCAAGATGCATTGGATTATATCACCTGGACTTACTTTTTCCGACGTCTTATCATGAATCCCAGCTATTA
CAATTTGGGTGATGTGAGCCATGATTCTGTGAACAAGTTTCTGTCCCATCTGATTGAGAAGTCCCTGATTGAATTGGAACTTTCCTACTG
TATTGAAATTGGAGAGGATAATCGCAGCATTGAACCTCTAACTTATGGCCGAATTGCCTCCTATTACTATTTGAAGCATCAAACAGTTAA
AATGTTCAAGGACCGCTTGAAGCCTGAATGCAGTACTGAAGAACTGCTTTCAATTCTAAGTGATGCAGAAGAATATACAGATTTGCCAGT
GAGACACAATGAAGATCATATGAATAGTGAACTGGCAAAATGTCTTCCCATTGAATCAAATCCTCATTCATTTGACAGCCCTCACACCAA
AGCACATCTCCTGCTACAGGCACATCTCAGCCGAGCCATGCTACCCTGCCCAGATTATGACACTGATACCAAAACAGTCTTGGACCAAGC
TCTCAGAGTATGTCAGGCAATGCTGGACGTGGCTGCAAACCAGGGCTGGCTGGTGACTGTCCTGAATATCACCAACCTGATTCAGATGGT
GATCCAGGGTCGGTGGTTAAAGGACTCTTCTCTTCTTACACTACCAAACATAGAAAACCATCATCTTCACCTTTTCAAGAAATGGAAGCC
GATTATGAAGGGCCCACATGCTAGGGGTCGGACCTCCATCGAGTCCCTTCCTGAACTGATCCATGCCTGTGGAGGGAAAGACCATGTATT
TAGCTCCATGGTAGAAAGTGAGCTACATGCTGCAAAAACGAAACAGGCATGGAATTTCTTATCTCACTTGCCAGTGATAAATGTTGGCAT
AAGTGTTAAAGGCTCGTGGGATGACTTAGTTGAAGGACATAATGAACTCTCTGTCTCAACTCTGACTGCAGACAAACGAGATGACAACAA
ATGGATCAAATTGCATGCTGACCAAGAGTATGTGCTTCAAGTGAGCTTGCAGAGAGTCCACTTTGGGTTCCACAAGGGAAAGCCAGAGAG
CTGTGCAGTTACTCCTCGATTTCCCAAATCAAAAGACGAAGGATGGTTTTTGATATTAGGAGAAGTGGATAAGAGAGAACTTATTGCTTT
GAAAAGAGTAGGATATATTCGAAATCATCATGTTGCTTCCCTTTCTTTTTATACCCCTGAAATACCTGGAAGGTATATCTACACATTATA
TTTCATGAGTGACTGCTACCTTGGCCTGGACCAGCAGTATGACATCTATCTCAACGTTACACAAGCGAGTCTTTCTGCACAGGTCAACAC
CAAGGTCTCTGATTCCCTGACTGACCTGGCATTAAAGTAACTTGACCTGAACAATCCATTTGAAAGGAGTGGCTAAGAATTCTCTCTGTT
CAGTCATCTAGACAAATCGAATTACTTGATGTTTGCCTTGAAAGAATCAACTTCTAACCTCAACCATCCAGGAAATTGACAGTGGCTGCA
GTATTGACTCCAGTGACATAAAGTTAACCACAGTGGCCTTTTAACAAATGTTGCCTTTTATAATGTTATCTTTATGAGTTTCTTGATATG
TAAGATGAAAAAGCATTTAGAATAATCTTTTAATTTGTGTATATTTGGGATGATATTTAGGAGCTATCAATCAAATTTTACATCTCACAA
TGTACTGTTTACATGGATATTGGCTGCTTTTTTTAAGGAAAACCACATTGAGATGTGACAAGTGTTAGGACTTGTCACAGATTTCTAACT
CTGCCGCATAAACTATAAATCTGTAAGGTGGTACACAGCGTGTCTTGTTAGCAAAATTTATACTTTGATATGATCACATGTAGAAGTAGC
TTCAAGAATTTCTTGTAGTCATAAATGTTTAATAATATATGATGTAAAATTATATTATGGAGCCTAATGATGATAACAAAGAAAACAATA
TACTGATCTTAGAAAATGTAGACATGGTTAACTGGGAAATAAAATATAGAGTGGCACTTCAAGACAAGCTGACTCAATGTTTTCTTCTGC
TTCCTTTAAATAATATCCCCTTACTCATCTGTTCTTCTTTTCTTTCCCTTCTACTTCAAGGCTTTATTTCTATTATCTTTCTGACATATT
TATTTACAGAAGTAGAGAAGTATAATCTAATTCATGTTGTAGCACTTACAGATCATATAGTACAATTATTTGTCTTTATGCTCTCCAGGA
AAAATCTGAGACAGAAAATTTTTCACCCCTATGGATAGGTTTTCACCTGTAATAAAGAAAATTTCTCTATGTCCAAACAAATTCCTTCTT
GAAAAATACTTTTTCAAACTAAAAACTTGTTAAAATTCAATGTTCATATAATATGCATTCTAGTGGAATGAAATTCTACCTTTGTGAAAT
AATTTCAGTTTTCTTAGCCCTAAAATGAATTATTTTAAAACATTTTCCAATGTCATTGTTACAAATACTAGAATTTAAGTGTTTCTGAAA

>6558_6558_1_ARL15-ASCC3_ARL15_chr5_53409032_ENST00000504924_ASCC3_chr6_101054966_ENST00000369162_length(amino acids)=792AA_BP=185
LLAFSGAARSQPETLLFFSGFGAVPDALGCRMSDLRITEAFLYMDYLCFRALCCKGPPPARPEYDLVCIGLTGSGKTSLLSKLCSESPDN
VVSTTGFSIKAVPFQNAILNVKELGGADNIRKYWSRYYQGSQGVIFVLDSASSEDDLEAARNELHSALQHPQLCTLPFLILANHQDKPAA
RSVQEMENIIATVRDSNLKLTLAFGIGMHHAGLHERDRKTVEELFVNCKVQVLIATSTLAWGVNFPAHLVIIKGTEYYDGKTRRYVDFPI
TDVLQMMGRAGRPQFDDQGKAVILVHDIKKDFYKKFLYEPFPVESSLLGVLSDHLNAEIAGGTITSKQDALDYITWTYFFRRLIMNPSYY
NLGDVSHDSVNKFLSHLIEKSLIELELSYCIEIGEDNRSIEPLTYGRIASYYYLKHQTVKMFKDRLKPECSTEELLSILSDAEEYTDLPV
RHNEDHMNSELAKCLPIESNPHSFDSPHTKAHLLLQAHLSRAMLPCPDYDTDTKTVLDQALRVCQAMLDVAANQGWLVTVLNITNLIQMV
IQGRWLKDSSLLTLPNIENHHLHLFKKWKPIMKGPHARGRTSIESLPELIHACGGKDHVFSSMVESELHAAKTKQAWNFLSHLPVINVGI
SVKGSWDDLVEGHNELSVSTLTADKRDDNKWIKLHADQEYVLQVSLQRVHFGFHKGKPESCAVTPRFPKSKDEGWFLILGEVDKRELIAL

--------------------------------------------------------------
>6558_6558_2_ARL15-ASCC3_ARL15_chr5_53409032_ENST00000507646_ASCC3_chr6_101054966_ENST00000369162_length(transcript)=3575nt_BP=559nt
GCTGTTGCTGGCTTTTTCAGGAGCTGCTCGCTCGCAGCCAGAGACGCTGCTTTTTTTTTCCGGGTTCGGAGCCGTTCCGGATGCTTTAGG
CTGCCGGATGTCTGATCTCCGAATAACTGAGGCGTTTCTGTACATGGATTATCTGTGTTTTAGAGCACTTTGCTGCAAGGGACCACCACC
TGCACGACCAGAATATGACCTGGTTTGCATAGGCCTCACAGGTTCTGGCAAAACCAGTCTGTTGTCCAAACTCTGCAGTGAAAGCCCCGA
TAACGTCGTGTCGACCACAGGTTTTAGTATTAAAGCAGTGCCATTCCAGAATGCCATCTTGAATGTAAAAGAACTTGGAGGGGCTGATAA
CATCCGGAAATACTGGAGCCGCTACTACCAAGGATCTCAAGGGGTAATATTTGTATTAGACAGTGCCTCTTCAGAGGATGATTTAGAAGC
TGCTAGAAATGAGCTGCACTCAGCTCTTCAGCATCCACAGTTATGCACTTTACCCTTTTTAATATTGGCCAATCATCAAGACAAGCCAGC
AGCTCGCTCAGTACAAGAGATGGAGAACATCATTGCAACAGTAAGAGATTCCAACCTCAAGCTGACCCTTGCTTTCGGGATAGGAATGCA
TCATGCTGGACTACATGAGAGGGACCGAAAAACAGTAGAGGAACTATTTGTAAACTGTAAAGTTCAGGTTCTTATTGCTACAAGCACATT
AGCCTGGGGTGTAAACTTTCCAGCTCATTTAGTAATTATTAAGGGAACAGAATACTATGATGGAAAAACAAGACGTTATGTGGATTTTCC
CATTACAGATGTCCTCCAGATGATGGGGCGTGCTGGGAGGCCGCAGTTCGATGACCAAGGCAAAGCTGTAATTCTAGTTCATGACATAAA
GAAAGACTTTTATAAAAAATTTCTTTATGAACCTTTCCCAGTAGAATCAAGTTTATTAGGAGTGCTCTCTGACCACTTAAATGCAGAGAT
TGCTGGTGGTACAATTACATCTAAGCAAGATGCATTGGATTATATCACCTGGACTTACTTTTTCCGACGTCTTATCATGAATCCCAGCTA
TTACAATTTGGGTGATGTGAGCCATGATTCTGTGAACAAGTTTCTGTCCCATCTGATTGAGAAGTCCCTGATTGAATTGGAACTTTCCTA
CTGTATTGAAATTGGAGAGGATAATCGCAGCATTGAACCTCTAACTTATGGCCGAATTGCCTCCTATTACTATTTGAAGCATCAAACAGT
TAAAATGTTCAAGGACCGCTTGAAGCCTGAATGCAGTACTGAAGAACTGCTTTCAATTCTAAGTGATGCAGAAGAATATACAGATTTGCC
AGTGAGACACAATGAAGATCATATGAATAGTGAACTGGCAAAATGTCTTCCCATTGAATCAAATCCTCATTCATTTGACAGCCCTCACAC
CAAAGCACATCTCCTGCTACAGGCACATCTCAGCCGAGCCATGCTACCCTGCCCAGATTATGACACTGATACCAAAACAGTCTTGGACCA
AGCTCTCAGAGTATGTCAGGCAATGCTGGACGTGGCTGCAAACCAGGGCTGGCTGGTGACTGTCCTGAATATCACCAACCTGATTCAGAT
GGTGATCCAGGGTCGGTGGTTAAAGGACTCTTCTCTTCTTACACTACCAAACATAGAAAACCATCATCTTCACCTTTTCAAGAAATGGAA
GCCGATTATGAAGGGCCCACATGCTAGGGGTCGGACCTCCATCGAGTCCCTTCCTGAACTGATCCATGCCTGTGGAGGGAAAGACCATGT
ATTTAGCTCCATGGTAGAAAGTGAGCTACATGCTGCAAAAACGAAACAGGCATGGAATTTCTTATCTCACTTGCCAGTGATAAATGTTGG
CATAAGTGTTAAAGGCTCGTGGGATGACTTAGTTGAAGGACATAATGAACTCTCTGTCTCAACTCTGACTGCAGACAAACGAGATGACAA
CAAATGGATCAAATTGCATGCTGACCAAGAGTATGTGCTTCAAGTGAGCTTGCAGAGAGTCCACTTTGGGTTCCACAAGGGAAAGCCAGA
GAGCTGTGCAGTTACTCCTCGATTTCCCAAATCAAAAGACGAAGGATGGTTTTTGATATTAGGAGAAGTGGATAAGAGAGAACTTATTGC
TTTGAAAAGAGTAGGATATATTCGAAATCATCATGTTGCTTCCCTTTCTTTTTATACCCCTGAAATACCTGGAAGGTATATCTACACATT
ATATTTCATGAGTGACTGCTACCTTGGCCTGGACCAGCAGTATGACATCTATCTCAACGTTACACAAGCGAGTCTTTCTGCACAGGTCAA
CACCAAGGTCTCTGATTCCCTGACTGACCTGGCATTAAAGTAACTTGACCTGAACAATCCATTTGAAAGGAGTGGCTAAGAATTCTCTCT
GTTCAGTCATCTAGACAAATCGAATTACTTGATGTTTGCCTTGAAAGAATCAACTTCTAACCTCAACCATCCAGGAAATTGACAGTGGCT
GCAGTATTGACTCCAGTGACATAAAGTTAACCACAGTGGCCTTTTAACAAATGTTGCCTTTTATAATGTTATCTTTATGAGTTTCTTGAT
ATGTAAGATGAAAAAGCATTTAGAATAATCTTTTAATTTGTGTATATTTGGGATGATATTTAGGAGCTATCAATCAAATTTTACATCTCA
CAATGTACTGTTTACATGGATATTGGCTGCTTTTTTTAAGGAAAACCACATTGAGATGTGACAAGTGTTAGGACTTGTCACAGATTTCTA
ACTCTGCCGCATAAACTATAAATCTGTAAGGTGGTACACAGCGTGTCTTGTTAGCAAAATTTATACTTTGATATGATCACATGTAGAAGT
AGCTTCAAGAATTTCTTGTAGTCATAAATGTTTAATAATATATGATGTAAAATTATATTATGGAGCCTAATGATGATAACAAAGAAAACA
ATATACTGATCTTAGAAAATGTAGACATGGTTAACTGGGAAATAAAATATAGAGTGGCACTTCAAGACAAGCTGACTCAATGTTTTCTTC
TGCTTCCTTTAAATAATATCCCCTTACTCATCTGTTCTTCTTTTCTTTCCCTTCTACTTCAAGGCTTTATTTCTATTATCTTTCTGACAT
ATTTATTTACAGAAGTAGAGAAGTATAATCTAATTCATGTTGTAGCACTTACAGATCATATAGTACAATTATTTGTCTTTATGCTCTCCA
GGAAAAATCTGAGACAGAAAATTTTTCACCCCTATGGATAGGTTTTCACCTGTAATAAAGAAAATTTCTCTATGTCCAAACAAATTCCTT
CTTGAAAAATACTTTTTCAAACTAAAAACTTGTTAAAATTCAATGTTCATATAATATGCATTCTAGTGGAATGAAATTCTACCTTTGTGA
AATAATTTCAGTTTTCTTAGCCCTAAAATGAATTATTTTAAAACATTTTCCAATGTCATTGTTACAAATACTAGAATTTAAGTGTTTCTG

>6558_6558_2_ARL15-ASCC3_ARL15_chr5_53409032_ENST00000507646_ASCC3_chr6_101054966_ENST00000369162_length(amino acids)=793AA_BP=186
LLLAFSGAARSQPETLLFFSGFGAVPDALGCRMSDLRITEAFLYMDYLCFRALCCKGPPPARPEYDLVCIGLTGSGKTSLLSKLCSESPD
NVVSTTGFSIKAVPFQNAILNVKELGGADNIRKYWSRYYQGSQGVIFVLDSASSEDDLEAARNELHSALQHPQLCTLPFLILANHQDKPA
ARSVQEMENIIATVRDSNLKLTLAFGIGMHHAGLHERDRKTVEELFVNCKVQVLIATSTLAWGVNFPAHLVIIKGTEYYDGKTRRYVDFP
ITDVLQMMGRAGRPQFDDQGKAVILVHDIKKDFYKKFLYEPFPVESSLLGVLSDHLNAEIAGGTITSKQDALDYITWTYFFRRLIMNPSY
YNLGDVSHDSVNKFLSHLIEKSLIELELSYCIEIGEDNRSIEPLTYGRIASYYYLKHQTVKMFKDRLKPECSTEELLSILSDAEEYTDLP
VRHNEDHMNSELAKCLPIESNPHSFDSPHTKAHLLLQAHLSRAMLPCPDYDTDTKTVLDQALRVCQAMLDVAANQGWLVTVLNITNLIQM
VIQGRWLKDSSLLTLPNIENHHLHLFKKWKPIMKGPHARGRTSIESLPELIHACGGKDHVFSSMVESELHAAKTKQAWNFLSHLPVINVG
ISVKGSWDDLVEGHNELSVSTLTADKRDDNKWIKLHADQEYVLQVSLQRVHFGFHKGKPESCAVTPRFPKSKDEGWFLILGEVDKRELIA

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Fusion Gene PPI Analysis for ARL15-ASCC3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARL15-ASCC3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARL15-ASCC3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource