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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:ARL15-ITGA1 (FusionGDB2 ID:6562) |
Fusion Gene Summary for ARL15-ITGA1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ARL15-ITGA1 | Fusion gene ID: 6562 | Hgene | Tgene | Gene symbol | ARL15 | ITGA1 | Gene ID | 54622 | 3672 |
| Gene name | ADP ribosylation factor like GTPase 15 | integrin subunit alpha 1 | |
| Synonyms | ARFRP2 | CD49a|VLA1 | |
| Cytomap | 5q11.2 | 5q11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ADP-ribosylation factor-like protein 15ADP-ribosylation factor-like 15ADP-ribosylation factor-related protein 2ARF-related protein 2 | integrin alpha-1CD49 antigen-like family member AVLA-1laminin and collagen receptorvery late activation protein 1 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | Q9NXU5 | Q9UKX5 | |
| Ensembl transtripts involved in fusion gene | ENST00000504924, ENST00000507646, ENST00000502271, ENST00000510591, | ENST00000504086, ENST00000282588, | |
| Fusion gene scores | * DoF score | 18 X 13 X 7=1638 | 3 X 3 X 2=18 |
| # samples | 18 | 3 | |
| ** MAII score | log2(18/1638*10)=-3.18586654531133 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ARL15 [Title/Abstract] AND ITGA1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | ARL15(53409032)-ITGA1(52243175), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ITGA1 | GO:0032516 | positive regulation of phosphoprotein phosphatase activity | 15592458 |
| Fusion gene breakpoints across ARL15 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across ITGA1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | SARC | TCGA-HS-A5N8-01A | ARL15 | chr5 | 53409032 | - | ITGA1 | chr5 | 52243175 | + |
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Fusion Gene ORF analysis for ARL15-ITGA1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000504924 | ENST00000504086 | ARL15 | chr5 | 53409032 | - | ITGA1 | chr5 | 52243175 | + |
| 5CDS-intron | ENST00000507646 | ENST00000504086 | ARL15 | chr5 | 53409032 | - | ITGA1 | chr5 | 52243175 | + |
| 5UTR-3CDS | ENST00000502271 | ENST00000282588 | ARL15 | chr5 | 53409032 | - | ITGA1 | chr5 | 52243175 | + |
| 5UTR-3CDS | ENST00000510591 | ENST00000282588 | ARL15 | chr5 | 53409032 | - | ITGA1 | chr5 | 52243175 | + |
| 5UTR-intron | ENST00000502271 | ENST00000504086 | ARL15 | chr5 | 53409032 | - | ITGA1 | chr5 | 52243175 | + |
| 5UTR-intron | ENST00000510591 | ENST00000504086 | ARL15 | chr5 | 53409032 | - | ITGA1 | chr5 | 52243175 | + |
| In-frame | ENST00000504924 | ENST00000282588 | ARL15 | chr5 | 53409032 | - | ITGA1 | chr5 | 52243175 | + |
| In-frame | ENST00000507646 | ENST00000282588 | ARL15 | chr5 | 53409032 | - | ITGA1 | chr5 | 52243175 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000504924 | ARL15 | chr5 | 53409032 | - | ENST00000282588 | ITGA1 | chr5 | 52243175 | + | 7477 | 556 | 1 | 717 | 238 |
| ENST00000507646 | ARL15 | chr5 | 53409032 | - | ENST00000282588 | ITGA1 | chr5 | 52243175 | + | 7480 | 559 | 1 | 720 | 239 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000504924 | ENST00000282588 | ARL15 | chr5 | 53409032 | - | ITGA1 | chr5 | 52243175 | + | 0.001359875 | 0.9986401 |
| ENST00000507646 | ENST00000282588 | ARL15 | chr5 | 53409032 | - | ITGA1 | chr5 | 52243175 | + | 0.001360349 | 0.99863964 |
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Fusion Genomic Features for ARL15-ITGA1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| ARL15 | chr5 | 53409031 | - | ITGA1 | chr5 | 52243174 | + | 0.000111995 | 0.99988794 |
| ARL15 | chr5 | 53409031 | - | ITGA1 | chr5 | 52243174 | + | 0.000111995 | 0.99988794 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for ARL15-ITGA1 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:53409032/chr5:52243175) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ARL15 | ITGA1 |
| FUNCTION: Integrin alpha-11/beta-1 is a receptor for collagen. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ARL15 | chr5:53409032 | chr5:52243175 | ENST00000504924 | - | 4 | 5 | 142_145 | 154 | 205.0 | Nucleotide binding | GTP |
| Hgene | ARL15 | chr5:53409032 | chr5:52243175 | ENST00000504924 | - | 4 | 5 | 39_46 | 154 | 205.0 | Nucleotide binding | GTP |
| Hgene | ARL15 | chr5:53409032 | chr5:52243175 | ENST00000504924 | - | 4 | 5 | 82_86 | 154 | 205.0 | Nucleotide binding | GTP |
| Tgene | ITGA1 | chr5:53409032 | chr5:52243175 | ENST00000282588 | 26 | 29 | 1167_1171 | 1126 | 1180.0 | Motif | Note=GFFKR motif | |
| Tgene | ITGA1 | chr5:53409032 | chr5:52243175 | ENST00000282588 | 26 | 29 | 1165_1179 | 1126 | 1180.0 | Topological domain | Cytoplasmic | |
| Tgene | ITGA1 | chr5:53409032 | chr5:52243175 | ENST00000282588 | 26 | 29 | 1142_1164 | 1126 | 1180.0 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | ITGA1 | chr5:53409032 | chr5:52243175 | ENST00000282588 | 26 | 29 | 498_506 | 1126 | 1180.0 | Calcium binding | Ontology_term=ECO:0000255 | |
| Tgene | ITGA1 | chr5:53409032 | chr5:52243175 | ENST00000282588 | 26 | 29 | 580_588 | 1126 | 1180.0 | Calcium binding | Ontology_term=ECO:0000255 | |
| Tgene | ITGA1 | chr5:53409032 | chr5:52243175 | ENST00000282588 | 26 | 29 | 642_650 | 1126 | 1180.0 | Calcium binding | Ontology_term=ECO:0000255 | |
| Tgene | ITGA1 | chr5:53409032 | chr5:52243175 | ENST00000282588 | 26 | 29 | 161_360 | 1126 | 1180.0 | Domain | VWFA | |
| Tgene | ITGA1 | chr5:53409032 | chr5:52243175 | ENST00000282588 | 26 | 29 | 101_160 | 1126 | 1180.0 | Repeat | FG-GAP 2 | |
| Tgene | ITGA1 | chr5:53409032 | chr5:52243175 | ENST00000282588 | 26 | 29 | 30_91 | 1126 | 1180.0 | Repeat | FG-GAP 1 | |
| Tgene | ITGA1 | chr5:53409032 | chr5:52243175 | ENST00000282588 | 26 | 29 | 365_417 | 1126 | 1180.0 | Repeat | FG-GAP 3 | |
| Tgene | ITGA1 | chr5:53409032 | chr5:52243175 | ENST00000282588 | 26 | 29 | 422_475 | 1126 | 1180.0 | Repeat | FG-GAP 4 | |
| Tgene | ITGA1 | chr5:53409032 | chr5:52243175 | ENST00000282588 | 26 | 29 | 476_538 | 1126 | 1180.0 | Repeat | FG-GAP 5 | |
| Tgene | ITGA1 | chr5:53409032 | chr5:52243175 | ENST00000282588 | 26 | 29 | 557_615 | 1126 | 1180.0 | Repeat | FG-GAP 6 | |
| Tgene | ITGA1 | chr5:53409032 | chr5:52243175 | ENST00000282588 | 26 | 29 | 619_679 | 1126 | 1180.0 | Repeat | FG-GAP 7 | |
| Tgene | ITGA1 | chr5:53409032 | chr5:52243175 | ENST00000282588 | 26 | 29 | 29_1141 | 1126 | 1180.0 | Topological domain | Extracellular |
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Fusion Gene Sequence for ARL15-ITGA1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >6562_6562_1_ARL15-ITGA1_ARL15_chr5_53409032_ENST00000504924_ITGA1_chr5_52243175_ENST00000282588_length(transcript)=7477nt_BP=556nt GTTGCTGGCTTTTTCAGGAGCTGCTCGCTCGCAGCCAGAGACGCTGCTTTTTTTTTCCGGGTTCGGAGCCGTTCCGGATGCTTTAGGCTG CCGGATGTCTGATCTCCGAATAACTGAGGCGTTTCTGTACATGGATTATCTGTGTTTTAGAGCACTTTGCTGCAAGGGACCACCACCTGC ACGACCAGAATATGACCTGGTTTGCATAGGCCTCACAGGTTCTGGCAAAACCAGTCTGTTGTCCAAACTCTGCAGTGAAAGCCCCGATAA CGTCGTGTCGACCACAGGTTTTAGTATTAAAGCAGTGCCATTCCAGAATGCCATCTTGAATGTAAAAGAACTTGGAGGGGCTGATAACAT CCGGAAATACTGGAGCCGCTACTACCAAGGATCTCAAGGGGTAATATTTGTATTAGACAGTGCCTCTTCAGAGGATGATTTAGAAGCTGC TAGAAATGAGCTGCACTCAGCTCTTCAGCATCCACAGTTATGCACTTTACCCTTTTTAATATTGGCCAATCATCAAGACAAGCCAGCAGC TCGCTCAGTACAAGAGCTTGCTATTCAAATATCCAAAGATGGGCTACCGGGCAGAGTGCCATTATGGGTCATCCTGCTGAGTGCTTTTGC CGGATTGTTGCTGTTAATGCTGCTCATTTTAGCACTGTGGAAGATTGGATTCTTCAAAAGACCACTGAAAAAGAAAATGGAGAAATGAAA TATTTTATGAAAGAAAATAATAACAATTATTCAATAATCTATCCTCAGGTTTGCCTCAAATATGTGACAAGAAATGTATAATTCATGACA TAGTCATGTAACTATGTAATCCATCAGGGATTCATTACTTGGAAAATGACAGGTCATGCATTATCCAAAAACAATACCAAAAAGACATAT TTTATAAAATGACAAAAAATATTTTACATAATTACTCATTTTTGTTGAGTAAGCAAAATTACAAAGTGTTTTTAAAAAAACCTGTACAAA TATGTTTATGTATTAAATCACCATCCAAAATATTTAAGGAATATATAAAAAGATTTTTATGATCATAGAAACATCTATTTTCAAAACAAT ATAAATTAAGCTTTTCCCCTTGATTCCTGTTGGATATCCATGTTCAGCATGACAGTCAGCACTCGTAAATGCCAAGAAAAGAATTACCTG AAAAAGATCATTTCTCCCTATTCAAATGAGAATATTTTCCCTTGGTAGAATCCATATACAATATGGATTGAAAATTAAGTCACCAAGAAT ACATTTAGCATCTTTGTGTTGGGTTCTATACCTAAAAATTTTCCCTCCCTGCCCAAGGTGATTGGAAAGTACTGCAATTGAGCTAAAATT TTATCTAGGATGGAAAATCAGGATAGACTCGTTTAAAAACAAGTATATTAAATGGGTTAAATTAAGCTTTTACAGAACATGCTTAATTTT GATATTGAGCTCTAAATGCAAAACTCTTTTATACTGAAAAAACACTTAAAGTAGTTTTGTGTGGCATCACAGTGATTTGTCATGAAAAGC CATATATGGGGGACATGCTAAAATGGCTTCTGAATGAAATACGACAGCAGAGAAAGATGCCACTGAAATGCTGAAATTATCTTTGCTGAG CAGCTTTTGAATGCTAAGGGTTCCAGTATGTGACCCAAAGAAAGAGTTGTCTCAACTCCTTGGTACAGGGTTCATTCAAACCCCCAAGCT GTGAGAGTGTGTTTATTTTTAATTTTTTAAAAGGTATTTAATTTCCAACCACACTTCTTATTTTTTTGAAAAGACAATTTTCCATTTCAG TATTACATTTTACCAAGAAGTCACTGCTTTTTAGGTGTGTTGCATCAATATTTAAATAAAATCCCAGAAATGTATTTTAAAGAATTTCAG GTTTGAAAACTCAAACCAACAGGAAGATATCACACCTTTGTATGTGCTTCTTTGTTCTTGAAGTAGTCATTATGGTTCATTGGAATCTAC TGTAGCATAAGCTCCTAGGTTGCTCCATTTCTTAGGAAAATAGCAATGAATGAATGTATAGTAGCTGCATGTGTGAACTACTGCTGTAAA GTTTGCTGACATTTCTGCAACAACATTTCTCCATCTGATTTACCAGAACCTGTAACAAGACCAGAACATGTATTCATCCAGAAACTCCTG GGCTCTGCTTTGTTCAAAGAGGAGCAAATCCACATAGAAATTAAATGTTATAAATTTATTTTTTTAAACTAATTTCCAAAGAATTTAGCT GAAGACTCAGAGTCAGCCTACCTCTTGACTCTCCACATCCGCATCTAAGATCCTGAAGGCCAAAGGAATGCGCCTGTGGGATGCCAAAGC CATCAGTAGCTGGAAGAAAGAATACCTCTTTCTAGAGGTTTGGTGTCCTCTTGCTGGCCTGTCATTATTTGGAAATACGCGCTTTTGGAA TTTCCTTCATTTTCGCTATTTCCAGGTTCAGAAATCATACCTACCACTTGTTCTTTCTTTGCCCAGTAAAACTCAGGGTTTCTCTTATTC AGAGTTACCATGTTGCACACCCCCAGTGCTCAGCCTGCCCAGAAGCCCTTCTCTGATCTCAGCAAGATCTTAGTAGTAAAGCTAACGGAT CCATTGAAATTCATACTCAGCATCTGTGACTACTAGACAAAGCCCATTTACTGAACCATAAGTGTGCACTTTTAAACTAAATTGTTAACT GAAAGGGAAAAAATAGAAATGAGGGCATTTTGAAGTTTTTAGAAAAGAGAGGAAGAGCTGTTGGCCAGATCAAAGAGATACTTATAAGCC CGGCACAATTTTTAACATAAGTCATTCCTGGCTATTAAGTAAAATATTTCATGAACCAGAAGTCCTGTTTCTCTAATATTATAATTTGTT GAGGTTTGTGTGTGTGTGTGTGTGCATGTGCAGACACATGTACACATATAAATTGAATACAAAAATAGCTCTATAACACCAAAAAACAGA GTTTACAGAAAATAAACACAAAAGCTATATCTGCAAGACAAGTTTGATTCATCTAGTTTCATATAGTTTCATATAGTTTCATTTTTATTA ATATTTAGGTTTAACTTATAGTTCTGCAATTATTTAAAAAACAAGTACAGAGCGTTTGATTAAAAAAAGTCAACAAATGTTTCAAAACAG CTTTGTACAAATGTTATAAAACATATTTAATGATTAAGAAATGTACTAGACTCTATCATTTACTTTTAAAACATTTAATTAGAAAAACAG GTGATATTTAAGACTATTTATAAACTTATTGGCCAAATTGCCAAAAAGTTTCTTTTTCTCTAACTTTGGTATTCTAAATAATTGATTATT GCTCCCATTGTAAACTGAACCATGTATGCACTCTCTTTTCTGACCAAACTACAATGGTATATTGGTAAATTATTTAACAACACACTGTCC AGGAGGGAAAAAAAAAACAGTCTCTGATTTGTATCATTTGCCAATTTCCATGGTCCAAATATTCTCTCTCCATTTTCAAACTACCAAAGT GACCCTAATCAGCTTACAAAATTCCTGGAAATGTATCTGCCACCTCTTACCAACCAGTGTGAGCTGACTTCAGCACACCACTGAGACAGA TTACACGATAGACAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATATTGATAGAGAACATGTTGTGTCTATATA CATATCCAATGACACACAGTATAATCATGTTTTAAATTATGCCAAAAGTACTGATTATATCAAGCCCAGTAAACATAATGCTACACAGCA CCCATTCTTTAATTTTGATTTCTAAAATTATAACCTTCCTTTGATATTAATAAAATGTTATGAACTTGCAGGAGAAGGAAGGAGTTGAAA GAAGGAAAATATAAAGGGTGATCCACAGTGAAAATCAGACCTACACAAGCCACAAAAAAATTGTCTCATTTTCCCAAGGAATTCAAAGTC CTGTGATACACATTACAAAAGATGACACTTTGTAAATATTTTGAACTTCTATGATCCAATTTCAACTTCATTGGTCCAATTTGTCAAACT ATTTTCCTCTGAGCACTAGATTCATGGGCAATTTAATCTCTGAATATTTTCTGTGTCATAAGTGTGCTTGAAAAGAGGCTTGTAGTAAAC AGATATTTTTACAAAATTTGATGCTTCTGCAACCATAATAATTTTATCTATAAATGCGTATATACATATATATATATATATATATACACA TACACTCACATGCAGATATTTACATATATAGATATTCTCTTTTCCTTTTATAAAATCAAAGTCTAGGCTCAATTGGAAAATGGAAATATT TGCACCAAAAGAAAAAAGTGCCATTGTTGTGATCAATGGAGTAAAGCTGGGGTATAGTAGAGGCTGGGGAATCCCTGCCCATGTTCTCTC CAAGGCCACAGCTTGCACACCGTGAATGGTGGCCCCACTGGCTCCATGGAGTGTGCCTTCACGCGGGGGAATGTCCTTGTCCAACACGCT GTAATCTACTCCATGGGAACTGACTGTCCTGCTTTTCACAACATTGAGAAACAGGCCCAGAGCCTGTCTCATGTGCCAGGTGCAGTCACA TTATTGTTAAAATAAAGTGGCTTCTGACAAATCAGTTTTTCAAAATAGCATCCTATGTACTTTTCATTTCTTCCAACAACCCTCAGGCCC CCTTTTGCCAGTTTTCTCCCCCAGGGGAGATTTTCAAGACTACTGGAGAAAAATCTGTTAATAAAACATTTGCTCTGAGTACCAGCTTCA GTGACTCAATCATTTATACAGGATTTCAGTGTTTTGTTCTGCAGCGGTGTTCTAAAGGGTTCACATAGTATAATGGAGGAGGGACAAAGC AGAATATACTTCCAAGCTGGAACATCTTTAAGACATTTACAAACTGTTATGGGACACTATCAGCAACTACGCCTGGGGAAGCTAGCAGGA TTTAGCTCTTCAATGGCCCTCCAAATGCACCCAACAATCGCCAACCTCACCCATGGAAATCATCTAAAAAATGAAAAGAAGGGCCTTAAA GTCCTCACATGGATGCTGTATTTATAACTAAAATGTACAGTTTAATTCTAAATAGCAGGCTTTTAAATGCAAACAGCTTCCAGGTGAGTC CTCTGGCTGCCAATCAGACTGCTGATTCTAAACCATTCTCACACAGAATTTCTGAAACCAACACCAGGTATTAATTGTTAACTGCAGTGA AAGGAAACCAAGGCACATTACAAAAGGCTAAATGCTGCTGTTTCTAAGTGGAAGCACTGTTGAACAACACTCTTAGGTGGAATAAGAAAA TTAGGGTTAAACTGTAACATTGTAATCGGACGAACAAATCAGCATCTTTGATCCTCAGGTTAAAATTTAATCTTAAATTTAGAAATTCAA AGTAACAGCCTTTAACCATTAACCTTGAGGAAAATGTGAAGTAGCATCTGGAGTCTCTTAAGCCCCAGCCCTGTTGTCCCCTACAGCATC TCCACCCAGGAAGTCCAGTTCCTAACTAATGGGAATGGATCCTTTTCCCATTATAAAGGGCCGATGCTTAACCCTTGAACCCACTACTGT TCTTATGCCCCAAGATCTGCACCTTACATCAGGCACCCGGGAATGCTTCTCATTGAAATTTTACCATACCAAAAAATATGTAAGGGTGAC TCATCACTCCTAACTTTGGACTCCTTGCTTTGAGATCGGTATTTTTTTCTCTCTCTTTACATATAGCAAAAGCTTTCCCCAGTAGCTGAT GAATTTAGAACTTTATACAAGACTCCCTAGCATTTTCCTCCTCCCACAGGCTGGAGAATTTCAGTGCTATGAGACTGGGCAGTAGGAGCC AGAGCCAATTTGCAGGATCTCTTTTCCTTCTGCCTTCCAGTTGGCTTCTCTTCTCAGCTGCGTGGTGGGGATGATTTGGGGTTTCCTCAG CAAGGCCATTCTCTGCCTTGTGCCCATAGCAGGGCCTTGGGTGGTGACATGTTATCTTTGTTGGTGAGCAGACACTCAGAGATCCTTTAA TTATCTGACACACCAGGGAAATCTTGGCAATCAACTAAGGACCTGTGACACTCATAACTATGTTTACATTTGGCTTTAGCATATTTCAGG TAATATCTTTATGAAAAAAAGATGAAGTATGGAATTGTAGGAACTCTTTTGCAATAGACTGAGATCCAATGTTTAAATCTTTTTATTTCA GTTTGATCTGTGCCTTTAGATTGGGGACAAAATTTTAAAAACAAATCTTCCAAATGACACCACAATGAAAGCCAGTTGTGGTCTTGAAAA ATCTCTCTATTGCATTACTTATCCTCACCCTTGTTTTTTAAGAGGTAGAGAGAGATTACTGGGAAGCAGTGAGCCAACATAATTGTCCTT TCCTCTACAGAATAGCTGTGCAGAAGGGGACCACCACACTTAGGACCAGTGCCAGGTGACAATCTTTCCGTCATGCTGCTGCAGCATTTT GCACCTTGAGAGACAGGAAAAAAAATGGGGGTGAGGGAGTGGAAGATGATGAAACTATTTCTCTTTTATGTCTACATCCTTACTCCTCAA AATACTTTAAGCTCACTCAGACCCCATATACCCTGCCCACAATACTAACACATGTACTTTGCATAAGTAAATTGTTGATTAAATAAGAGC AAAACTATATTCTTATGTGTAGATTAACCAAGGCTAATTTCCTGGAGTTTAATACACTTTGGATTCAAGTAAAAACAATCACTTAATGCA GCAACATCTCAGACCCTCTTCACTCTAGAACCGTTTTATACAAGAGAACTCAACATTTACTGTTTTATTTCTGATATTGCCTGCCATTAC TCAGGATGCAAGAGATGCTCTGCATTCCTTATTAGGAAAAATTGGCCTGTAAGGAGAATGGTATACTGCGTATTACTACTGTGAGACTGT AAAATTGTTAATGGACAGTGTAAAGAATTGTATTCATTTTATTAGCAAGAAAAATATTGCATACAAGAACTACTGCCCTGAAATATCCAT CACTCCAATGAACTGTTCTGCCTGATCTAACATAAAGTTATATTTCATTGCTCATTTTTTTTTGCCTCACTAAAATGACTAACTTAAGGG AATGTGCATTTCTACAAGACTTTAATTGGATAAACTCATTAGAAGAAAATGTTTCGATTGCATTCAGGAACAAAGAAGCATAACCTTTGT TGACTCTTGTAATTTATTATATGCTTCATTTAAACCCATTTTGTAAAGAAATCAGGTAACAGTCATTTAATCTGATATAATTAGAAATAG CTGAGAGAGTAAAAAAGCATTTTGAATGTCCTATGTATGGCATATCCTGTACACCAATTGAAGGTCAGAGCTTTGGTATTTTTGTATAAT TCTGTCTTATCTGGTGCATCAGCTGTGTATTTTACGTCAAGGTAAATGAGCATCCTGTTTTATATGTTAAATTTTAAAAATGACTTTTTC >6562_6562_1_ARL15-ITGA1_ARL15_chr5_53409032_ENST00000504924_ITGA1_chr5_52243175_ENST00000282588_length(amino acids)=238AA_BP=185 LLAFSGAARSQPETLLFFSGFGAVPDALGCRMSDLRITEAFLYMDYLCFRALCCKGPPPARPEYDLVCIGLTGSGKTSLLSKLCSESPDN VVSTTGFSIKAVPFQNAILNVKELGGADNIRKYWSRYYQGSQGVIFVLDSASSEDDLEAARNELHSALQHPQLCTLPFLILANHQDKPAA -------------------------------------------------------------- >6562_6562_2_ARL15-ITGA1_ARL15_chr5_53409032_ENST00000507646_ITGA1_chr5_52243175_ENST00000282588_length(transcript)=7480nt_BP=559nt GCTGTTGCTGGCTTTTTCAGGAGCTGCTCGCTCGCAGCCAGAGACGCTGCTTTTTTTTTCCGGGTTCGGAGCCGTTCCGGATGCTTTAGG CTGCCGGATGTCTGATCTCCGAATAACTGAGGCGTTTCTGTACATGGATTATCTGTGTTTTAGAGCACTTTGCTGCAAGGGACCACCACC TGCACGACCAGAATATGACCTGGTTTGCATAGGCCTCACAGGTTCTGGCAAAACCAGTCTGTTGTCCAAACTCTGCAGTGAAAGCCCCGA TAACGTCGTGTCGACCACAGGTTTTAGTATTAAAGCAGTGCCATTCCAGAATGCCATCTTGAATGTAAAAGAACTTGGAGGGGCTGATAA CATCCGGAAATACTGGAGCCGCTACTACCAAGGATCTCAAGGGGTAATATTTGTATTAGACAGTGCCTCTTCAGAGGATGATTTAGAAGC TGCTAGAAATGAGCTGCACTCAGCTCTTCAGCATCCACAGTTATGCACTTTACCCTTTTTAATATTGGCCAATCATCAAGACAAGCCAGC AGCTCGCTCAGTACAAGAGCTTGCTATTCAAATATCCAAAGATGGGCTACCGGGCAGAGTGCCATTATGGGTCATCCTGCTGAGTGCTTT TGCCGGATTGTTGCTGTTAATGCTGCTCATTTTAGCACTGTGGAAGATTGGATTCTTCAAAAGACCACTGAAAAAGAAAATGGAGAAATG AAATATTTTATGAAAGAAAATAATAACAATTATTCAATAATCTATCCTCAGGTTTGCCTCAAATATGTGACAAGAAATGTATAATTCATG ACATAGTCATGTAACTATGTAATCCATCAGGGATTCATTACTTGGAAAATGACAGGTCATGCATTATCCAAAAACAATACCAAAAAGACA TATTTTATAAAATGACAAAAAATATTTTACATAATTACTCATTTTTGTTGAGTAAGCAAAATTACAAAGTGTTTTTAAAAAAACCTGTAC AAATATGTTTATGTATTAAATCACCATCCAAAATATTTAAGGAATATATAAAAAGATTTTTATGATCATAGAAACATCTATTTTCAAAAC AATATAAATTAAGCTTTTCCCCTTGATTCCTGTTGGATATCCATGTTCAGCATGACAGTCAGCACTCGTAAATGCCAAGAAAAGAATTAC CTGAAAAAGATCATTTCTCCCTATTCAAATGAGAATATTTTCCCTTGGTAGAATCCATATACAATATGGATTGAAAATTAAGTCACCAAG AATACATTTAGCATCTTTGTGTTGGGTTCTATACCTAAAAATTTTCCCTCCCTGCCCAAGGTGATTGGAAAGTACTGCAATTGAGCTAAA ATTTTATCTAGGATGGAAAATCAGGATAGACTCGTTTAAAAACAAGTATATTAAATGGGTTAAATTAAGCTTTTACAGAACATGCTTAAT TTTGATATTGAGCTCTAAATGCAAAACTCTTTTATACTGAAAAAACACTTAAAGTAGTTTTGTGTGGCATCACAGTGATTTGTCATGAAA AGCCATATATGGGGGACATGCTAAAATGGCTTCTGAATGAAATACGACAGCAGAGAAAGATGCCACTGAAATGCTGAAATTATCTTTGCT GAGCAGCTTTTGAATGCTAAGGGTTCCAGTATGTGACCCAAAGAAAGAGTTGTCTCAACTCCTTGGTACAGGGTTCATTCAAACCCCCAA GCTGTGAGAGTGTGTTTATTTTTAATTTTTTAAAAGGTATTTAATTTCCAACCACACTTCTTATTTTTTTGAAAAGACAATTTTCCATTT CAGTATTACATTTTACCAAGAAGTCACTGCTTTTTAGGTGTGTTGCATCAATATTTAAATAAAATCCCAGAAATGTATTTTAAAGAATTT CAGGTTTGAAAACTCAAACCAACAGGAAGATATCACACCTTTGTATGTGCTTCTTTGTTCTTGAAGTAGTCATTATGGTTCATTGGAATC TACTGTAGCATAAGCTCCTAGGTTGCTCCATTTCTTAGGAAAATAGCAATGAATGAATGTATAGTAGCTGCATGTGTGAACTACTGCTGT AAAGTTTGCTGACATTTCTGCAACAACATTTCTCCATCTGATTTACCAGAACCTGTAACAAGACCAGAACATGTATTCATCCAGAAACTC CTGGGCTCTGCTTTGTTCAAAGAGGAGCAAATCCACATAGAAATTAAATGTTATAAATTTATTTTTTTAAACTAATTTCCAAAGAATTTA GCTGAAGACTCAGAGTCAGCCTACCTCTTGACTCTCCACATCCGCATCTAAGATCCTGAAGGCCAAAGGAATGCGCCTGTGGGATGCCAA AGCCATCAGTAGCTGGAAGAAAGAATACCTCTTTCTAGAGGTTTGGTGTCCTCTTGCTGGCCTGTCATTATTTGGAAATACGCGCTTTTG GAATTTCCTTCATTTTCGCTATTTCCAGGTTCAGAAATCATACCTACCACTTGTTCTTTCTTTGCCCAGTAAAACTCAGGGTTTCTCTTA TTCAGAGTTACCATGTTGCACACCCCCAGTGCTCAGCCTGCCCAGAAGCCCTTCTCTGATCTCAGCAAGATCTTAGTAGTAAAGCTAACG GATCCATTGAAATTCATACTCAGCATCTGTGACTACTAGACAAAGCCCATTTACTGAACCATAAGTGTGCACTTTTAAACTAAATTGTTA ACTGAAAGGGAAAAAATAGAAATGAGGGCATTTTGAAGTTTTTAGAAAAGAGAGGAAGAGCTGTTGGCCAGATCAAAGAGATACTTATAA GCCCGGCACAATTTTTAACATAAGTCATTCCTGGCTATTAAGTAAAATATTTCATGAACCAGAAGTCCTGTTTCTCTAATATTATAATTT GTTGAGGTTTGTGTGTGTGTGTGTGTGCATGTGCAGACACATGTACACATATAAATTGAATACAAAAATAGCTCTATAACACCAAAAAAC AGAGTTTACAGAAAATAAACACAAAAGCTATATCTGCAAGACAAGTTTGATTCATCTAGTTTCATATAGTTTCATATAGTTTCATTTTTA TTAATATTTAGGTTTAACTTATAGTTCTGCAATTATTTAAAAAACAAGTACAGAGCGTTTGATTAAAAAAAGTCAACAAATGTTTCAAAA CAGCTTTGTACAAATGTTATAAAACATATTTAATGATTAAGAAATGTACTAGACTCTATCATTTACTTTTAAAACATTTAATTAGAAAAA CAGGTGATATTTAAGACTATTTATAAACTTATTGGCCAAATTGCCAAAAAGTTTCTTTTTCTCTAACTTTGGTATTCTAAATAATTGATT ATTGCTCCCATTGTAAACTGAACCATGTATGCACTCTCTTTTCTGACCAAACTACAATGGTATATTGGTAAATTATTTAACAACACACTG TCCAGGAGGGAAAAAAAAAACAGTCTCTGATTTGTATCATTTGCCAATTTCCATGGTCCAAATATTCTCTCTCCATTTTCAAACTACCAA AGTGACCCTAATCAGCTTACAAAATTCCTGGAAATGTATCTGCCACCTCTTACCAACCAGTGTGAGCTGACTTCAGCACACCACTGAGAC AGATTACACGATAGACAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATATTGATAGAGAACATGTTGTGTCTAT ATACATATCCAATGACACACAGTATAATCATGTTTTAAATTATGCCAAAAGTACTGATTATATCAAGCCCAGTAAACATAATGCTACACA GCACCCATTCTTTAATTTTGATTTCTAAAATTATAACCTTCCTTTGATATTAATAAAATGTTATGAACTTGCAGGAGAAGGAAGGAGTTG AAAGAAGGAAAATATAAAGGGTGATCCACAGTGAAAATCAGACCTACACAAGCCACAAAAAAATTGTCTCATTTTCCCAAGGAATTCAAA GTCCTGTGATACACATTACAAAAGATGACACTTTGTAAATATTTTGAACTTCTATGATCCAATTTCAACTTCATTGGTCCAATTTGTCAA ACTATTTTCCTCTGAGCACTAGATTCATGGGCAATTTAATCTCTGAATATTTTCTGTGTCATAAGTGTGCTTGAAAAGAGGCTTGTAGTA AACAGATATTTTTACAAAATTTGATGCTTCTGCAACCATAATAATTTTATCTATAAATGCGTATATACATATATATATATATATATATAC ACATACACTCACATGCAGATATTTACATATATAGATATTCTCTTTTCCTTTTATAAAATCAAAGTCTAGGCTCAATTGGAAAATGGAAAT ATTTGCACCAAAAGAAAAAAGTGCCATTGTTGTGATCAATGGAGTAAAGCTGGGGTATAGTAGAGGCTGGGGAATCCCTGCCCATGTTCT CTCCAAGGCCACAGCTTGCACACCGTGAATGGTGGCCCCACTGGCTCCATGGAGTGTGCCTTCACGCGGGGGAATGTCCTTGTCCAACAC GCTGTAATCTACTCCATGGGAACTGACTGTCCTGCTTTTCACAACATTGAGAAACAGGCCCAGAGCCTGTCTCATGTGCCAGGTGCAGTC ACATTATTGTTAAAATAAAGTGGCTTCTGACAAATCAGTTTTTCAAAATAGCATCCTATGTACTTTTCATTTCTTCCAACAACCCTCAGG CCCCCTTTTGCCAGTTTTCTCCCCCAGGGGAGATTTTCAAGACTACTGGAGAAAAATCTGTTAATAAAACATTTGCTCTGAGTACCAGCT TCAGTGACTCAATCATTTATACAGGATTTCAGTGTTTTGTTCTGCAGCGGTGTTCTAAAGGGTTCACATAGTATAATGGAGGAGGGACAA AGCAGAATATACTTCCAAGCTGGAACATCTTTAAGACATTTACAAACTGTTATGGGACACTATCAGCAACTACGCCTGGGGAAGCTAGCA GGATTTAGCTCTTCAATGGCCCTCCAAATGCACCCAACAATCGCCAACCTCACCCATGGAAATCATCTAAAAAATGAAAAGAAGGGCCTT AAAGTCCTCACATGGATGCTGTATTTATAACTAAAATGTACAGTTTAATTCTAAATAGCAGGCTTTTAAATGCAAACAGCTTCCAGGTGA GTCCTCTGGCTGCCAATCAGACTGCTGATTCTAAACCATTCTCACACAGAATTTCTGAAACCAACACCAGGTATTAATTGTTAACTGCAG TGAAAGGAAACCAAGGCACATTACAAAAGGCTAAATGCTGCTGTTTCTAAGTGGAAGCACTGTTGAACAACACTCTTAGGTGGAATAAGA AAATTAGGGTTAAACTGTAACATTGTAATCGGACGAACAAATCAGCATCTTTGATCCTCAGGTTAAAATTTAATCTTAAATTTAGAAATT CAAAGTAACAGCCTTTAACCATTAACCTTGAGGAAAATGTGAAGTAGCATCTGGAGTCTCTTAAGCCCCAGCCCTGTTGTCCCCTACAGC ATCTCCACCCAGGAAGTCCAGTTCCTAACTAATGGGAATGGATCCTTTTCCCATTATAAAGGGCCGATGCTTAACCCTTGAACCCACTAC TGTTCTTATGCCCCAAGATCTGCACCTTACATCAGGCACCCGGGAATGCTTCTCATTGAAATTTTACCATACCAAAAAATATGTAAGGGT GACTCATCACTCCTAACTTTGGACTCCTTGCTTTGAGATCGGTATTTTTTTCTCTCTCTTTACATATAGCAAAAGCTTTCCCCAGTAGCT GATGAATTTAGAACTTTATACAAGACTCCCTAGCATTTTCCTCCTCCCACAGGCTGGAGAATTTCAGTGCTATGAGACTGGGCAGTAGGA GCCAGAGCCAATTTGCAGGATCTCTTTTCCTTCTGCCTTCCAGTTGGCTTCTCTTCTCAGCTGCGTGGTGGGGATGATTTGGGGTTTCCT CAGCAAGGCCATTCTCTGCCTTGTGCCCATAGCAGGGCCTTGGGTGGTGACATGTTATCTTTGTTGGTGAGCAGACACTCAGAGATCCTT TAATTATCTGACACACCAGGGAAATCTTGGCAATCAACTAAGGACCTGTGACACTCATAACTATGTTTACATTTGGCTTTAGCATATTTC AGGTAATATCTTTATGAAAAAAAGATGAAGTATGGAATTGTAGGAACTCTTTTGCAATAGACTGAGATCCAATGTTTAAATCTTTTTATT TCAGTTTGATCTGTGCCTTTAGATTGGGGACAAAATTTTAAAAACAAATCTTCCAAATGACACCACAATGAAAGCCAGTTGTGGTCTTGA AAAATCTCTCTATTGCATTACTTATCCTCACCCTTGTTTTTTAAGAGGTAGAGAGAGATTACTGGGAAGCAGTGAGCCAACATAATTGTC CTTTCCTCTACAGAATAGCTGTGCAGAAGGGGACCACCACACTTAGGACCAGTGCCAGGTGACAATCTTTCCGTCATGCTGCTGCAGCAT TTTGCACCTTGAGAGACAGGAAAAAAAATGGGGGTGAGGGAGTGGAAGATGATGAAACTATTTCTCTTTTATGTCTACATCCTTACTCCT CAAAATACTTTAAGCTCACTCAGACCCCATATACCCTGCCCACAATACTAACACATGTACTTTGCATAAGTAAATTGTTGATTAAATAAG AGCAAAACTATATTCTTATGTGTAGATTAACCAAGGCTAATTTCCTGGAGTTTAATACACTTTGGATTCAAGTAAAAACAATCACTTAAT GCAGCAACATCTCAGACCCTCTTCACTCTAGAACCGTTTTATACAAGAGAACTCAACATTTACTGTTTTATTTCTGATATTGCCTGCCAT TACTCAGGATGCAAGAGATGCTCTGCATTCCTTATTAGGAAAAATTGGCCTGTAAGGAGAATGGTATACTGCGTATTACTACTGTGAGAC TGTAAAATTGTTAATGGACAGTGTAAAGAATTGTATTCATTTTATTAGCAAGAAAAATATTGCATACAAGAACTACTGCCCTGAAATATC CATCACTCCAATGAACTGTTCTGCCTGATCTAACATAAAGTTATATTTCATTGCTCATTTTTTTTTGCCTCACTAAAATGACTAACTTAA GGGAATGTGCATTTCTACAAGACTTTAATTGGATAAACTCATTAGAAGAAAATGTTTCGATTGCATTCAGGAACAAAGAAGCATAACCTT TGTTGACTCTTGTAATTTATTATATGCTTCATTTAAACCCATTTTGTAAAGAAATCAGGTAACAGTCATTTAATCTGATATAATTAGAAA TAGCTGAGAGAGTAAAAAAGCATTTTGAATGTCCTATGTATGGCATATCCTGTACACCAATTGAAGGTCAGAGCTTTGGTATTTTTGTAT AATTCTGTCTTATCTGGTGCATCAGCTGTGTATTTTACGTCAAGGTAAATGAGCATCCTGTTTTATATGTTAAATTTTAAAAATGACTTT >6562_6562_2_ARL15-ITGA1_ARL15_chr5_53409032_ENST00000507646_ITGA1_chr5_52243175_ENST00000282588_length(amino acids)=239AA_BP=186 LLLAFSGAARSQPETLLFFSGFGAVPDALGCRMSDLRITEAFLYMDYLCFRALCCKGPPPARPEYDLVCIGLTGSGKTSLLSKLCSESPD NVVSTTGFSIKAVPFQNAILNVKELGGADNIRKYWSRYYQGSQGVIFVLDSASSEDDLEAARNELHSALQHPQLCTLPFLILANHQDKPA -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for ARL15-ITGA1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ARL15-ITGA1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ARL15-ITGA1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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