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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PKN1-POLA2 (FusionGDB2 ID:65775)

Fusion Gene Summary for PKN1-POLA2

check button Fusion gene summary
Fusion gene informationFusion gene name: PKN1-POLA2
Fusion gene ID: 65775
HgeneTgene
Gene symbol

PKN1

POLA2

Gene ID

5585

23649

Gene nameprotein kinase N1DNA polymerase alpha 2, accessory subunit
SynonymsDBK|PAK-1|PAK1|PKN|PKN-ALPHA|PRK1|PRKCL1-
Cytomap

19p13.12

11q13.1

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase N1protease-activated kinase 1protein kinase C-like 1protein kinase C-like PKNprotein kinase C-related kinase 1protein kinase PKN-alphaserine-threonine kinase Nserine/threonine protein kinase NDNA polymerase alpha subunit BDNA polymerase alpha 70 kDa subunitpolymerase (DNA directed), alpha 2 (70kD subunit)polymerase (DNA directed), alpha 2, accessory subunitpolymerase (DNA) alpha 2, accessory subunitpolymerase (DNA-directed), alpha (70kD)
Modification date2020032920200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000587429, ENST00000242783, 
ENST00000342216, 		ENST00000265465, 
ENST00000541089, ENST00000534785, 
Fusion gene scores* DoF score10 X 7 X 8=56010 X 14 X 6=840
# samples 1216
** MAII scorelog2(12/560*10)=-2.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/840*10)=-2.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PKN1 [Title/Abstract] AND POLA2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPKN1(14544354)-POLA2(65062016), # samples:1
PKN1(14544354)-POLA2(65062017), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePKN1

GO:0006357

regulation of transcription by RNA polymerase II

12514133

HgenePKN1

GO:0006468

protein phosphorylation

17332740

HgenePKN1

GO:0035407

histone H3-T11 phosphorylation

18066052


check buttonFusion gene breakpoints across PKN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across POLA2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-BK-A139-02APKN1chr19

14544354

+POLA2chr11

65062017

+
ChimerDB4UCECTCGA-BK-A139PKN1chr19

14544354

+POLA2chr11

65062016

+


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Fusion Gene ORF analysis for PKN1-POLA2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000587429ENST00000265465PKN1chr19

14544354

+POLA2chr11

65062017

+
3UTR-3CDSENST00000587429ENST00000265465PKN1chr19

14544354

+POLA2chr11

65062016

+
3UTR-3CDSENST00000587429ENST00000541089PKN1chr19

14544354

+POLA2chr11

65062017

+
3UTR-3CDSENST00000587429ENST00000541089PKN1chr19

14544354

+POLA2chr11

65062016

+
3UTR-3UTRENST00000587429ENST00000534785PKN1chr19

14544354

+POLA2chr11

65062017

+
3UTR-3UTRENST00000587429ENST00000534785PKN1chr19

14544354

+POLA2chr11

65062016

+
5CDS-3UTRENST00000242783ENST00000534785PKN1chr19

14544354

+POLA2chr11

65062017

+
5CDS-3UTRENST00000242783ENST00000534785PKN1chr19

14544354

+POLA2chr11

65062016

+
In-frameENST00000242783ENST00000265465PKN1chr19

14544354

+POLA2chr11

65062017

+
In-frameENST00000242783ENST00000265465PKN1chr19

14544354

+POLA2chr11

65062016

+
In-frameENST00000242783ENST00000541089PKN1chr19

14544354

+POLA2chr11

65062017

+
In-frameENST00000242783ENST00000541089PKN1chr19

14544354

+POLA2chr11

65062016

+
intron-3CDSENST00000342216ENST00000265465PKN1chr19

14544354

+POLA2chr11

65062017

+
intron-3CDSENST00000342216ENST00000265465PKN1chr19

14544354

+POLA2chr11

65062016

+
intron-3CDSENST00000342216ENST00000541089PKN1chr19

14544354

+POLA2chr11

65062017

+
intron-3CDSENST00000342216ENST00000541089PKN1chr19

14544354

+POLA2chr11

65062016

+
intron-3UTRENST00000342216ENST00000534785PKN1chr19

14544354

+POLA2chr11

65062017

+
intron-3UTRENST00000342216ENST00000534785PKN1chr19

14544354

+POLA2chr11

65062016

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000242783PKN1chr1914544354+ENST00000265465POLA2chr1165062016+2046186165629154
ENST00000242783PKN1chr1914544354+ENST00000541089POLA2chr1165062016+700186165542125
ENST00000242783PKN1chr1914544354+ENST00000265465POLA2chr1165062017+2046186165629154
ENST00000242783PKN1chr1914544354+ENST00000541089POLA2chr1165062017+700186165542125

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000242783ENST00000265465PKN1chr1914544354+POLA2chr1165062016+0.0154161250.98458385
ENST00000242783ENST00000541089PKN1chr1914544354+POLA2chr1165062016+0.010762010.989238
ENST00000242783ENST00000265465PKN1chr1914544354+POLA2chr1165062017+0.0154161250.98458385
ENST00000242783ENST00000541089PKN1chr1914544354+POLA2chr1165062017+0.010762010.989238

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Fusion Genomic Features for PKN1-POLA2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PKN1chr1914544354+POLA2chr1165062016+0.0002539050.99974614
PKN1chr1914544354+POLA2chr1165062016+0.0002539050.99974614
PKN1chr1914544354+POLA2chr1165062016+0.0002539050.99974614
PKN1chr1914544354+POLA2chr1165062016+0.0002539050.99974614

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PKN1-POLA2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:14544354/chr11:65062016)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePOLA2chr19:14544354chr11:65062016ENST000002654651318486_489451599.0Compositional biasNote=Poly-Ser
TgenePOLA2chr19:14544354chr11:65062017ENST000002654651318486_489451599.0Compositional biasNote=Poly-Ser

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePKN1chr19:14544354chr11:65062016ENST00000242783+122112_1937943.0DomainREM-1 2
HgenePKN1chr19:14544354chr11:65062016ENST00000242783+122201_2807943.0DomainREM-1 3
HgenePKN1chr19:14544354chr11:65062016ENST00000242783+12225_1007943.0DomainREM-1 1
HgenePKN1chr19:14544354chr11:65062016ENST00000242783+122307_4707943.0DomainC2
HgenePKN1chr19:14544354chr11:65062016ENST00000242783+122615_8747943.0DomainProtein kinase
HgenePKN1chr19:14544354chr11:65062016ENST00000242783+122875_9427943.0DomainAGC-kinase C-terminal
HgenePKN1chr19:14544354chr11:65062016ENST00000342216+122112_1930949.0DomainREM-1 2
HgenePKN1chr19:14544354chr11:65062016ENST00000342216+122201_2800949.0DomainREM-1 3
HgenePKN1chr19:14544354chr11:65062016ENST00000342216+12225_1000949.0DomainREM-1 1
HgenePKN1chr19:14544354chr11:65062016ENST00000342216+122307_4700949.0DomainC2
HgenePKN1chr19:14544354chr11:65062016ENST00000342216+122615_8740949.0DomainProtein kinase
HgenePKN1chr19:14544354chr11:65062016ENST00000342216+122875_9420949.0DomainAGC-kinase C-terminal
HgenePKN1chr19:14544354chr11:65062017ENST00000242783+122112_1937943.0DomainREM-1 2
HgenePKN1chr19:14544354chr11:65062017ENST00000242783+122201_2807943.0DomainREM-1 3
HgenePKN1chr19:14544354chr11:65062017ENST00000242783+12225_1007943.0DomainREM-1 1
HgenePKN1chr19:14544354chr11:65062017ENST00000242783+122307_4707943.0DomainC2
HgenePKN1chr19:14544354chr11:65062017ENST00000242783+122615_8747943.0DomainProtein kinase
HgenePKN1chr19:14544354chr11:65062017ENST00000242783+122875_9427943.0DomainAGC-kinase C-terminal
HgenePKN1chr19:14544354chr11:65062017ENST00000342216+122112_1930949.0DomainREM-1 2
HgenePKN1chr19:14544354chr11:65062017ENST00000342216+122201_2800949.0DomainREM-1 3
HgenePKN1chr19:14544354chr11:65062017ENST00000342216+12225_1000949.0DomainREM-1 1
HgenePKN1chr19:14544354chr11:65062017ENST00000342216+122307_4700949.0DomainC2
HgenePKN1chr19:14544354chr11:65062017ENST00000342216+122615_8740949.0DomainProtein kinase
HgenePKN1chr19:14544354chr11:65062017ENST00000342216+122875_9420949.0DomainAGC-kinase C-terminal
HgenePKN1chr19:14544354chr11:65062016ENST00000242783+122621_6297943.0Nucleotide bindingATP
HgenePKN1chr19:14544354chr11:65062016ENST00000342216+122621_6290949.0Nucleotide bindingATP
HgenePKN1chr19:14544354chr11:65062017ENST00000242783+122621_6297943.0Nucleotide bindingATP
HgenePKN1chr19:14544354chr11:65062017ENST00000342216+122621_6290949.0Nucleotide bindingATP
TgenePOLA2chr19:14544354chr11:65062016ENST000002654651318101_107451599.0Compositional biasNote=Poly-Glu
TgenePOLA2chr19:14544354chr11:65062016ENST000002654651318115_157451599.0Compositional biasNote=Pro/Ser/Thr-rich
TgenePOLA2chr19:14544354chr11:65062017ENST000002654651318101_107451599.0Compositional biasNote=Poly-Glu
TgenePOLA2chr19:14544354chr11:65062017ENST000002654651318115_157451599.0Compositional biasNote=Pro/Ser/Thr-rich


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Fusion Gene Sequence for PKN1-POLA2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>65775_65775_1_PKN1-POLA2_PKN1_chr19_14544354_ENST00000242783_POLA2_chr11_65062016_ENST00000265465_length(transcript)=2046nt_BP=186nt
CGGCGGCCTGGCCAGGCGAGGCGGGAGCCGAGCAGGCCGGAGCGGGCCGCGCGCCGGGGAGGGTCGCGCCGCGCCCGCCCCCTCCCCGCC
ACGCCCGGGGCGCACGCGCGCTCCTCTGGCCGCCCCTCCCTCCGCGCGGGGACCCCTGGCGGGCGGCAGGAGGACATGGCCAGCGACGCC
GTGCAGCAAGTACAGTTTGTGTCCGAGCCCTGCAGCCTCTCCATAAACGGAGTGATCTTCGGCTTGACATCCACAGATCTGCTTTTCCAC
CTGGGGGCCGAGGAGATCAGTAGTTCTTCCGGAACTTCAGACAGATTCAGCCGAATACTCAAGCACATCTTGACCCAGAGGAGCTACTAC
CCACTCTACCCGCCCCAAGAAGACATGGCCATTGACTATGAGTCGTTCTATGTTTACGCACAGCTGCCTGTCACCCCAGATGTCCTCATC
ATCCCGTCAGAGCTGAGGTACTTCGTGAAGGATGTCCTCGGCTGTGTCTGTGTGAACCCTGGGCGCCTTACCAAAGGGCAGGTGGGAGGC
ACCTTCGCCCGACTCTACCTTAGGAGGCCGGCAGCGGACGGGGCAGAGAGGCAGAGCCCATGCATTGCTGTGCAGGTCGTCAGGATCTGA
GGCTTCTGTCCTCTGCTGTTCTCTGCTGTGTGGGCCCTTAAAGTCTTAGCCAAGAGCCAAGACATAGCCCTGTGACAAGGTGAACAGTTG
GGTGGGAAAGGAGAGAGGAGCCAGCCAGGGAGGGGCAGCTGCAGTGACCAGGCCCAGCAGGGAGGACTTGTGCAGCCGGGCCTGCCTCTG
AGTGGTGCCTCTCCTGGAAGGAAGCTCTTGCTTCTCAGTCCATGCTCCGTGTCCAGAAGTAAGCCAGCTGTGGATCCCGCCCACTCAGAA
AAGGCGAGAAGGCTTTGTGATTTTCTACATGAATCAAACACAGAAACAACTTTTGGAGAAATTAAATTCTGAGTGTGACTTCTGAGTTTG
ACCTTTCTTCTATTTTCTTTTATTTATTTATTTTGTTTTTAGACGGAGTCTCGATCTGTCGCCCAGGCTGGAGTGCAGTGGTGAGATCTC
GGCTCACTGCAAGCTCTGCCGCCCGGGTTCATGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCACCCACCACCACGC
CTGGCTAATTTTTTGTATTTTTAGTGGAGATGGGGTTTCACCATGTTAGCCAGGATGGTCTCGATCTCCTGACCTTGTGATCTGTCCGCC
TCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCCGGCCCCTTTCTTCTATTTTCTTTATCCTGGTAGTAGACAAAGAA
TGTTGCCTATTTGACCTATGTCCAGAGAAGGCAGAGTGTCAGTCACACTGGGTTTCTATCCAGCCCCAGTCCTGTCCAGTGGGTAACTCT
CAGCCCCACTCCTCATCCCCCAAAGGCCCCAGTGACCTCTATGCTGCAGAGGTGCACTGGGTGGGCCCTAGAGCTGGGCTGCAGAGCAAG
CAACTGGCTGCATGCCTGGGCCTCCCTGCGCAGTTCCTCACATGCATGCTGTGGTCCCAGCCTGACCTCTCCATCTGGAGGGGGCCGCCT
CGCTGGGCTGTTCCAAAGCTGGAGTCCTGGTGGCAGCTGCTTTGCCAAGTCGCGCAGTAGCCAGGGCTTGCCTGCAGCCCAGAACACTCA
GACAGGGTCAGGCCTTCCAGGGTTCACAGCACGTCCCATGCCCCTATGTCCTGGCATCTGGGGAAAAGCTGTCACTGGCCAGACGTGGAG
TGGCTTCCTGCCCTAAGCTGGCAGGCTGTCCTGCCTCACATGCCAGAGCCAAGACCGGCAAACCCCAGCTGTCAGGGCAGGGAAGTGGGC
AAGGGGGCAGCAAGCTGCTGGTGTCTATGCCTTGACTCCGAGATAAATAGATGACCTAACAGTGGCCAACTTTTGCCTCTCACCTTTCTG

>65775_65775_1_PKN1-POLA2_PKN1_chr19_14544354_ENST00000242783_POLA2_chr11_65062016_ENST00000265465_length(amino acids)=154AA_BP=7
MASDAVQQVQFVSEPCSLSINGVIFGLTSTDLLFHLGAEEISSSSGTSDRFSRILKHILTQRSYYPLYPPQEDMAIDYESFYVYAQLPVT

--------------------------------------------------------------
>65775_65775_2_PKN1-POLA2_PKN1_chr19_14544354_ENST00000242783_POLA2_chr11_65062016_ENST00000541089_length(transcript)=700nt_BP=186nt
CGGCGGCCTGGCCAGGCGAGGCGGGAGCCGAGCAGGCCGGAGCGGGCCGCGCGCCGGGGAGGGTCGCGCCGCGCCCGCCCCCTCCCCGCC
ACGCCCGGGGCGCACGCGCGCTCCTCTGGCCGCCCCTCCCTCCGCGCGGGGACCCCTGGCGGGCGGCAGGAGGACATGGCCAGCGACGCC
GTGCAGCAAGTACAGTTTGTGTCCGAGCCCTGCAGCCTCTCCATAAACGGAGTGATCTTCGGCTTGACATCCACAGATCTGCTTTTCCAC
CTGGGGGCCGAGGAGATCAGTAGTTCTTCCGGAACTTCAGACAGATTCAGCCGAATACTCAAGCACATCTTGACCCAGAGGAGCTACTAC
CCACTCTACCCGCCCCAAGAAGACATGGCCATTGACTATGAGTCGTTCTATGTTTACGCACAGCTGCCTGTCACCCCAGATGTCCTCATC
ATCCCGTCAGAGCTGAGGTACTTCGTGAAGGTAGGTTTGAACTCTGCTTTTTCCCAGAAACACCAGAACCCAGTCTTTGACTTTCCCTTC
TAGACCACCCGGCACTCACCCCTCATGGGTCAGCTGATGGGGATGGGGCCTCTAGCACCCTGCCCTGTGGCCTTGTTTCTTTGGGGAGGT

>65775_65775_2_PKN1-POLA2_PKN1_chr19_14544354_ENST00000242783_POLA2_chr11_65062016_ENST00000541089_length(amino acids)=125AA_BP=7
MASDAVQQVQFVSEPCSLSINGVIFGLTSTDLLFHLGAEEISSSSGTSDRFSRILKHILTQRSYYPLYPPQEDMAIDYESFYVYAQLPVT

--------------------------------------------------------------
>65775_65775_3_PKN1-POLA2_PKN1_chr19_14544354_ENST00000242783_POLA2_chr11_65062017_ENST00000265465_length(transcript)=2046nt_BP=186nt
CGGCGGCCTGGCCAGGCGAGGCGGGAGCCGAGCAGGCCGGAGCGGGCCGCGCGCCGGGGAGGGTCGCGCCGCGCCCGCCCCCTCCCCGCC
ACGCCCGGGGCGCACGCGCGCTCCTCTGGCCGCCCCTCCCTCCGCGCGGGGACCCCTGGCGGGCGGCAGGAGGACATGGCCAGCGACGCC
GTGCAGCAAGTACAGTTTGTGTCCGAGCCCTGCAGCCTCTCCATAAACGGAGTGATCTTCGGCTTGACATCCACAGATCTGCTTTTCCAC
CTGGGGGCCGAGGAGATCAGTAGTTCTTCCGGAACTTCAGACAGATTCAGCCGAATACTCAAGCACATCTTGACCCAGAGGAGCTACTAC
CCACTCTACCCGCCCCAAGAAGACATGGCCATTGACTATGAGTCGTTCTATGTTTACGCACAGCTGCCTGTCACCCCAGATGTCCTCATC
ATCCCGTCAGAGCTGAGGTACTTCGTGAAGGATGTCCTCGGCTGTGTCTGTGTGAACCCTGGGCGCCTTACCAAAGGGCAGGTGGGAGGC
ACCTTCGCCCGACTCTACCTTAGGAGGCCGGCAGCGGACGGGGCAGAGAGGCAGAGCCCATGCATTGCTGTGCAGGTCGTCAGGATCTGA
GGCTTCTGTCCTCTGCTGTTCTCTGCTGTGTGGGCCCTTAAAGTCTTAGCCAAGAGCCAAGACATAGCCCTGTGACAAGGTGAACAGTTG
GGTGGGAAAGGAGAGAGGAGCCAGCCAGGGAGGGGCAGCTGCAGTGACCAGGCCCAGCAGGGAGGACTTGTGCAGCCGGGCCTGCCTCTG
AGTGGTGCCTCTCCTGGAAGGAAGCTCTTGCTTCTCAGTCCATGCTCCGTGTCCAGAAGTAAGCCAGCTGTGGATCCCGCCCACTCAGAA
AAGGCGAGAAGGCTTTGTGATTTTCTACATGAATCAAACACAGAAACAACTTTTGGAGAAATTAAATTCTGAGTGTGACTTCTGAGTTTG
ACCTTTCTTCTATTTTCTTTTATTTATTTATTTTGTTTTTAGACGGAGTCTCGATCTGTCGCCCAGGCTGGAGTGCAGTGGTGAGATCTC
GGCTCACTGCAAGCTCTGCCGCCCGGGTTCATGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCACCCACCACCACGC
CTGGCTAATTTTTTGTATTTTTAGTGGAGATGGGGTTTCACCATGTTAGCCAGGATGGTCTCGATCTCCTGACCTTGTGATCTGTCCGCC
TCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCCGGCCCCTTTCTTCTATTTTCTTTATCCTGGTAGTAGACAAAGAA
TGTTGCCTATTTGACCTATGTCCAGAGAAGGCAGAGTGTCAGTCACACTGGGTTTCTATCCAGCCCCAGTCCTGTCCAGTGGGTAACTCT
CAGCCCCACTCCTCATCCCCCAAAGGCCCCAGTGACCTCTATGCTGCAGAGGTGCACTGGGTGGGCCCTAGAGCTGGGCTGCAGAGCAAG
CAACTGGCTGCATGCCTGGGCCTCCCTGCGCAGTTCCTCACATGCATGCTGTGGTCCCAGCCTGACCTCTCCATCTGGAGGGGGCCGCCT
CGCTGGGCTGTTCCAAAGCTGGAGTCCTGGTGGCAGCTGCTTTGCCAAGTCGCGCAGTAGCCAGGGCTTGCCTGCAGCCCAGAACACTCA
GACAGGGTCAGGCCTTCCAGGGTTCACAGCACGTCCCATGCCCCTATGTCCTGGCATCTGGGGAAAAGCTGTCACTGGCCAGACGTGGAG
TGGCTTCCTGCCCTAAGCTGGCAGGCTGTCCTGCCTCACATGCCAGAGCCAAGACCGGCAAACCCCAGCTGTCAGGGCAGGGAAGTGGGC
AAGGGGGCAGCAAGCTGCTGGTGTCTATGCCTTGACTCCGAGATAAATAGATGACCTAACAGTGGCCAACTTTTGCCTCTCACCTTTCTG

>65775_65775_3_PKN1-POLA2_PKN1_chr19_14544354_ENST00000242783_POLA2_chr11_65062017_ENST00000265465_length(amino acids)=154AA_BP=7
MASDAVQQVQFVSEPCSLSINGVIFGLTSTDLLFHLGAEEISSSSGTSDRFSRILKHILTQRSYYPLYPPQEDMAIDYESFYVYAQLPVT

--------------------------------------------------------------
>65775_65775_4_PKN1-POLA2_PKN1_chr19_14544354_ENST00000242783_POLA2_chr11_65062017_ENST00000541089_length(transcript)=700nt_BP=186nt
CGGCGGCCTGGCCAGGCGAGGCGGGAGCCGAGCAGGCCGGAGCGGGCCGCGCGCCGGGGAGGGTCGCGCCGCGCCCGCCCCCTCCCCGCC
ACGCCCGGGGCGCACGCGCGCTCCTCTGGCCGCCCCTCCCTCCGCGCGGGGACCCCTGGCGGGCGGCAGGAGGACATGGCCAGCGACGCC
GTGCAGCAAGTACAGTTTGTGTCCGAGCCCTGCAGCCTCTCCATAAACGGAGTGATCTTCGGCTTGACATCCACAGATCTGCTTTTCCAC
CTGGGGGCCGAGGAGATCAGTAGTTCTTCCGGAACTTCAGACAGATTCAGCCGAATACTCAAGCACATCTTGACCCAGAGGAGCTACTAC
CCACTCTACCCGCCCCAAGAAGACATGGCCATTGACTATGAGTCGTTCTATGTTTACGCACAGCTGCCTGTCACCCCAGATGTCCTCATC
ATCCCGTCAGAGCTGAGGTACTTCGTGAAGGTAGGTTTGAACTCTGCTTTTTCCCAGAAACACCAGAACCCAGTCTTTGACTTTCCCTTC
TAGACCACCCGGCACTCACCCCTCATGGGTCAGCTGATGGGGATGGGGCCTCTAGCACCCTGCCCTGTGGCCTTGTTTCTTTGGGGAGGT

>65775_65775_4_PKN1-POLA2_PKN1_chr19_14544354_ENST00000242783_POLA2_chr11_65062017_ENST00000541089_length(amino acids)=125AA_BP=7
MASDAVQQVQFVSEPCSLSINGVIFGLTSTDLLFHLGAEEISSSSGTSDRFSRILKHILTQRSYYPLYPPQEDMAIDYESFYVYAQLPVT

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Fusion Gene PPI Analysis for PKN1-POLA2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PKN1-POLA2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PKN1-POLA2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource