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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PKN2-COL24A1 (FusionGDB2 ID:65782)

Fusion Gene Summary for PKN2-COL24A1

check button Fusion gene summary
Fusion gene informationFusion gene name: PKN2-COL24A1
Fusion gene ID: 65782
HgeneTgene
Gene symbol

PKN2

COL24A1

Gene ID

5586

255631

Gene nameprotein kinase N2collagen type XXIV alpha 1 chain
SynonymsPAK2|PRK2|PRKCL2|PRO2042|Pak-2|STK7-
Cytomap

1p22.2

1p22.3

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase N2PKN gammacardiolipin-activated protein kinase Pak2protein kinase C-like 2protein-kinase C-related kinase 2collagen alpha-1(XXIV) chaincollagen, type XXIV, alpha 1
Modification date2020031320200313
UniProtAcc.

Q17RW2

Ensembl transtripts involved in fusion geneENST00000316005, ENST00000370513, 
ENST00000370521, ENST00000370505, 
ENST00000495119, ENST00000544045, 
ENST00000485434, ENST00000370571, 
ENST00000436319, 
Fusion gene scores* DoF score5 X 5 X 2=505 X 5 X 3=75
# samples 55
** MAII scorelog2(5/50*10)=0log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PKN2 [Title/Abstract] AND COL24A1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPKN2(89150311)-COL24A1(86453337), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePKN2

GO:0006468

protein phosphorylation

17332740

HgenePKN2

GO:0010631

epithelial cell migration

21754995


check buttonFusion gene breakpoints across PKN2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across COL24A1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AN-A0FV-01APKN2chr1

89150311

-COL24A1chr1

86453337

-
ChimerDB4BRCATCGA-AN-A0FV-01APKN2chr1

89150311

+COL24A1chr1

86453337

-


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Fusion Gene ORF analysis for PKN2-COL24A1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000316005ENST00000485434PKN2chr1

89150311

+COL24A1chr1

86453337

-
5CDS-intronENST00000370513ENST00000485434PKN2chr1

89150311

+COL24A1chr1

86453337

-
5CDS-intronENST00000370521ENST00000485434PKN2chr1

89150311

+COL24A1chr1

86453337

-
5UTR-3CDSENST00000370505ENST00000370571PKN2chr1

89150311

+COL24A1chr1

86453337

-
5UTR-3CDSENST00000370505ENST00000436319PKN2chr1

89150311

+COL24A1chr1

86453337

-
5UTR-intronENST00000370505ENST00000485434PKN2chr1

89150311

+COL24A1chr1

86453337

-
In-frameENST00000316005ENST00000370571PKN2chr1

89150311

+COL24A1chr1

86453337

-
In-frameENST00000316005ENST00000436319PKN2chr1

89150311

+COL24A1chr1

86453337

-
In-frameENST00000370513ENST00000370571PKN2chr1

89150311

+COL24A1chr1

86453337

-
In-frameENST00000370513ENST00000436319PKN2chr1

89150311

+COL24A1chr1

86453337

-
In-frameENST00000370521ENST00000370571PKN2chr1

89150311

+COL24A1chr1

86453337

-
In-frameENST00000370521ENST00000436319PKN2chr1

89150311

+COL24A1chr1

86453337

-
intron-3CDSENST00000495119ENST00000370571PKN2chr1

89150311

+COL24A1chr1

86453337

-
intron-3CDSENST00000495119ENST00000436319PKN2chr1

89150311

+COL24A1chr1

86453337

-
intron-3CDSENST00000544045ENST00000370571PKN2chr1

89150311

+COL24A1chr1

86453337

-
intron-3CDSENST00000544045ENST00000436319PKN2chr1

89150311

+COL24A1chr1

86453337

-
intron-intronENST00000495119ENST00000485434PKN2chr1

89150311

+COL24A1chr1

86453337

-
intron-intronENST00000544045ENST00000485434PKN2chr1

89150311

+COL24A1chr1

86453337

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000316005PKN2chr189150311+ENST00000436319COL24A1chr186453337-44924072213178985
ENST00000316005PKN2chr189150311+ENST00000370571COL24A1chr186453337-455540722132411006
ENST00000370521PKN2chr189150311+ENST00000436319COL24A1chr186453337-44924072213178985
ENST00000370521PKN2chr189150311+ENST00000370571COL24A1chr186453337-455540722132411006
ENST00000370513PKN2chr189150311+ENST00000436319COL24A1chr186453337-41415682827939
ENST00000370513PKN2chr189150311+ENST00000370571COL24A1chr186453337-42045682890960

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000316005ENST00000436319PKN2chr189150311+COL24A1chr186453337-0.0002631050.99973685
ENST00000316005ENST00000370571PKN2chr189150311+COL24A1chr186453337-0.0002606490.99973935
ENST00000370521ENST00000436319PKN2chr189150311+COL24A1chr186453337-0.0002631050.99973685
ENST00000370521ENST00000370571PKN2chr189150311+COL24A1chr186453337-0.0002606490.99973935
ENST00000370513ENST00000436319PKN2chr189150311+COL24A1chr186453337-0.0002556690.99974436
ENST00000370513ENST00000370571PKN2chr189150311+COL24A1chr186453337-0.0002578790.9997421

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Fusion Genomic Features for PKN2-COL24A1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PKN2-COL24A1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:89150311/chr1:86453337)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.COL24A1

Q17RW2

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: May participate in regulating type I collagen fibrillogenesis at specific anatomical locations during fetal development. {ECO:0000269|PubMed:12874293}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCOL24A1chr1:89150311chr1:86453337ENST0000037057118601011_10527701715.0DomainNote=Collagen-like 9
TgeneCOL24A1chr1:89150311chr1:86453337ENST0000037057118601053_11127701715.0DomainNote=Collagen-like 10
TgeneCOL24A1chr1:89150311chr1:86453337ENST0000037057118601116_11707701715.0DomainNote=Collagen-like 11
TgeneCOL24A1chr1:89150311chr1:86453337ENST0000037057118601172_11967701715.0DomainNote=Collagen-like 12
TgeneCOL24A1chr1:89150311chr1:86453337ENST0000037057118601201_12497701715.0DomainNote=Collagen-like 13
TgeneCOL24A1chr1:89150311chr1:86453337ENST0000037057118601252_13067701715.0DomainNote=Collagen-like 14
TgeneCOL24A1chr1:89150311chr1:86453337ENST0000037057118601309_13537701715.0DomainNote=Collagen-like 15
TgeneCOL24A1chr1:89150311chr1:86453337ENST0000037057118601354_14137701715.0DomainNote=Collagen-like 16
TgeneCOL24A1chr1:89150311chr1:86453337ENST0000037057118601420_14797701715.0DomainNote=Collagen-like 17
TgeneCOL24A1chr1:89150311chr1:86453337ENST0000037057118601515_17147701715.0DomainFibrillar collagen NC1
TgeneCOL24A1chr1:89150311chr1:86453337ENST000003705711860798_8577701715.0DomainNote=Collagen-like 5
TgeneCOL24A1chr1:89150311chr1:86453337ENST000003705711860858_8877701715.0DomainNote=Collagen-like 6
TgeneCOL24A1chr1:89150311chr1:86453337ENST000003705711860888_9477701715.0DomainNote=Collagen-like 7
TgeneCOL24A1chr1:89150311chr1:86453337ENST000003705711860948_10077701715.0DomainNote=Collagen-like 8
TgeneCOL24A1chr1:89150311chr1:86453337ENST0000043631918581011_10527701694.0DomainNote=Collagen-like 9
TgeneCOL24A1chr1:89150311chr1:86453337ENST0000043631918581053_11127701694.0DomainNote=Collagen-like 10
TgeneCOL24A1chr1:89150311chr1:86453337ENST0000043631918581116_11707701694.0DomainNote=Collagen-like 11
TgeneCOL24A1chr1:89150311chr1:86453337ENST0000043631918581172_11967701694.0DomainNote=Collagen-like 12
TgeneCOL24A1chr1:89150311chr1:86453337ENST0000043631918581201_12497701694.0DomainNote=Collagen-like 13
TgeneCOL24A1chr1:89150311chr1:86453337ENST0000043631918581252_13067701694.0DomainNote=Collagen-like 14
TgeneCOL24A1chr1:89150311chr1:86453337ENST0000043631918581309_13537701694.0DomainNote=Collagen-like 15
TgeneCOL24A1chr1:89150311chr1:86453337ENST0000043631918581354_14137701694.0DomainNote=Collagen-like 16
TgeneCOL24A1chr1:89150311chr1:86453337ENST0000043631918581420_14797701694.0DomainNote=Collagen-like 17
TgeneCOL24A1chr1:89150311chr1:86453337ENST0000043631918581515_17147701694.0DomainFibrillar collagen NC1
TgeneCOL24A1chr1:89150311chr1:86453337ENST000004363191858798_8577701694.0DomainNote=Collagen-like 5
TgeneCOL24A1chr1:89150311chr1:86453337ENST000004363191858858_8877701694.0DomainNote=Collagen-like 6
TgeneCOL24A1chr1:89150311chr1:86453337ENST000004363191858888_9477701694.0DomainNote=Collagen-like 7
TgeneCOL24A1chr1:89150311chr1:86453337ENST000004363191858948_10077701694.0DomainNote=Collagen-like 8

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePKN2chr1:89150311chr1:86453337ENST00000370505+121121_2030828.0DomainREM-1 2
HgenePKN2chr1:89150311chr1:86453337ENST00000370505+121204_2840828.0DomainREM-1 3
HgenePKN2chr1:89150311chr1:86453337ENST00000370505+12133_1090828.0DomainREM-1 1
HgenePKN2chr1:89150311chr1:86453337ENST00000370505+121353_4730828.0DomainC2
HgenePKN2chr1:89150311chr1:86453337ENST00000370505+121657_9160828.0DomainProtein kinase
HgenePKN2chr1:89150311chr1:86453337ENST00000370505+121917_9840828.0DomainAGC-kinase C-terminal
HgenePKN2chr1:89150311chr1:86453337ENST00000370513+121121_20316937.0DomainREM-1 2
HgenePKN2chr1:89150311chr1:86453337ENST00000370513+121204_28416937.0DomainREM-1 3
HgenePKN2chr1:89150311chr1:86453337ENST00000370513+12133_10916937.0DomainREM-1 1
HgenePKN2chr1:89150311chr1:86453337ENST00000370513+121353_47316937.0DomainC2
HgenePKN2chr1:89150311chr1:86453337ENST00000370513+121657_91616937.0DomainProtein kinase
HgenePKN2chr1:89150311chr1:86453337ENST00000370513+121917_98416937.0DomainAGC-kinase C-terminal
HgenePKN2chr1:89150311chr1:86453337ENST00000370521+122121_20316985.0DomainREM-1 2
HgenePKN2chr1:89150311chr1:86453337ENST00000370521+122204_28416985.0DomainREM-1 3
HgenePKN2chr1:89150311chr1:86453337ENST00000370521+12233_10916985.0DomainREM-1 1
HgenePKN2chr1:89150311chr1:86453337ENST00000370521+122353_47316985.0DomainC2
HgenePKN2chr1:89150311chr1:86453337ENST00000370521+122657_91616985.0DomainProtein kinase
HgenePKN2chr1:89150311chr1:86453337ENST00000370521+122917_98416985.0DomainAGC-kinase C-terminal
HgenePKN2chr1:89150311chr1:86453337ENST00000544045+117121_2030659.0DomainREM-1 2
HgenePKN2chr1:89150311chr1:86453337ENST00000544045+117204_2840659.0DomainREM-1 3
HgenePKN2chr1:89150311chr1:86453337ENST00000544045+11733_1090659.0DomainREM-1 1
HgenePKN2chr1:89150311chr1:86453337ENST00000544045+117353_4730659.0DomainC2
HgenePKN2chr1:89150311chr1:86453337ENST00000544045+117657_9160659.0DomainProtein kinase
HgenePKN2chr1:89150311chr1:86453337ENST00000544045+117917_9840659.0DomainAGC-kinase C-terminal
HgenePKN2chr1:89150311chr1:86453337ENST00000370505+121663_6710828.0Nucleotide bindingATP
HgenePKN2chr1:89150311chr1:86453337ENST00000370513+121663_67116937.0Nucleotide bindingATP
HgenePKN2chr1:89150311chr1:86453337ENST00000370521+122663_67116985.0Nucleotide bindingATP
HgenePKN2chr1:89150311chr1:86453337ENST00000544045+117663_6710659.0Nucleotide bindingATP
HgenePKN2chr1:89150311chr1:86453337ENST00000370505+121382_4630828.0RegionNecessary to rescue apical junction formation
HgenePKN2chr1:89150311chr1:86453337ENST00000370505+121917_9770828.0RegionNote=Necessary for the catalytic activity
HgenePKN2chr1:89150311chr1:86453337ENST00000370505+121978_9840828.0RegionNote=Negatively regulates the responsiveness of the catalytic activity by cardiolipin and is required for optimal activation by the GTP-bound RhoA
HgenePKN2chr1:89150311chr1:86453337ENST00000370513+121382_46316937.0RegionNecessary to rescue apical junction formation
HgenePKN2chr1:89150311chr1:86453337ENST00000370513+121917_97716937.0RegionNote=Necessary for the catalytic activity
HgenePKN2chr1:89150311chr1:86453337ENST00000370513+121978_98416937.0RegionNote=Negatively regulates the responsiveness of the catalytic activity by cardiolipin and is required for optimal activation by the GTP-bound RhoA
HgenePKN2chr1:89150311chr1:86453337ENST00000370521+122382_46316985.0RegionNecessary to rescue apical junction formation
HgenePKN2chr1:89150311chr1:86453337ENST00000370521+122917_97716985.0RegionNote=Necessary for the catalytic activity
HgenePKN2chr1:89150311chr1:86453337ENST00000370521+122978_98416985.0RegionNote=Negatively regulates the responsiveness of the catalytic activity by cardiolipin and is required for optimal activation by the GTP-bound RhoA
HgenePKN2chr1:89150311chr1:86453337ENST00000544045+117382_4630659.0RegionNecessary to rescue apical junction formation
HgenePKN2chr1:89150311chr1:86453337ENST00000544045+117917_9770659.0RegionNote=Necessary for the catalytic activity
HgenePKN2chr1:89150311chr1:86453337ENST00000544045+117978_9840659.0RegionNote=Negatively regulates the responsiveness of the catalytic activity by cardiolipin and is required for optimal activation by the GTP-bound RhoA
TgeneCOL24A1chr1:89150311chr1:86453337ENST000003705711860470_4757701715.0Compositional biasNote=Poly-Tyr
TgeneCOL24A1chr1:89150311chr1:86453337ENST000004363191858470_4757701694.0Compositional biasNote=Poly-Tyr
TgeneCOL24A1chr1:89150311chr1:86453337ENST000003705711860141_2177701715.0DomainNote=Laminin G-like
TgeneCOL24A1chr1:89150311chr1:86453337ENST000003705711860487_5427701715.0DomainNote=Collagen-like 1
TgeneCOL24A1chr1:89150311chr1:86453337ENST000003705711860552_6117701715.0DomainNote=Collagen-like 2
TgeneCOL24A1chr1:89150311chr1:86453337ENST000003705711860660_7197701715.0DomainNote=Collagen-like 3
TgeneCOL24A1chr1:89150311chr1:86453337ENST000003705711860741_7977701715.0DomainNote=Collagen-like 4
TgeneCOL24A1chr1:89150311chr1:86453337ENST000004363191858141_2177701694.0DomainNote=Laminin G-like
TgeneCOL24A1chr1:89150311chr1:86453337ENST000004363191858487_5427701694.0DomainNote=Collagen-like 1
TgeneCOL24A1chr1:89150311chr1:86453337ENST000004363191858552_6117701694.0DomainNote=Collagen-like 2
TgeneCOL24A1chr1:89150311chr1:86453337ENST000004363191858660_7197701694.0DomainNote=Collagen-like 3
TgeneCOL24A1chr1:89150311chr1:86453337ENST000004363191858741_7977701694.0DomainNote=Collagen-like 4


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Fusion Gene Sequence for PKN2-COL24A1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>65782_65782_1_PKN2-COL24A1_PKN2_chr1_89150311_ENST00000316005_COL24A1_chr1_86453337_ENST00000370571_length(transcript)=4555nt_BP=407nt
GCTTTTGCGACGCGGTGACAGCCAAATGGTGCGACAGGAGGAGCTGCAGCCGCGGCCGCAGCGCCCGCACGGAGAGGCTTGAGGCGGCTC
CTGGCGTCGCCCAGAGGGAGCGACTAGACGAACAGTCCGGTGAGGGCGGCGAGAGGAAGCCCGCTACGAGTGCCCTAGCTCCCCGCCGCT
CTCGATGAACCGGACGGAATAAGCCGCGCCTCCAGCAGGGGCTGCGCCTCCATGAATCCCTAGTTGTTTTTTTTTTTTTCTTTCTCTCCC
CTCTCCTCACCCCCACCCCGAGCCCCGTCCCGCCTTCTCCCTTCGCCAGAGGCGGCCGCGTCCAGGTGCGGAGTCCATACCGGAGCGCAA
TGGCGTCCAACCCCGAACGGGGGGAGATTCTGCTCACGGAACTGCAGGGTTTTCCAGGAGATATTGGGATTCCTGGACAAAACGGCCCTG
AAGGACCAAAGGGACTCCTTGGAAATAGAGGACCTCCTGGACCTCCTGGTCTCAAAGGAACTCAGGGAGAAGAAGGACCAATTGGAGCCT
TTGGGGAACTGGGGCCAAGAGGAAAACCAGGTCAAAAGGGGTATGCAGGTGAACCAGGACCAGAAGGCTTAAAGGGAGAAGTAGGAGATC
AAGGAAATATTGGAAAAATTGGTGAAACAGGACCTGTTGGCTTACCTGGAGAAGTTGGGATGACTGGAAGCATTGGCGAAAAGGGAGAAC
GTGGAAGTCCAGGCCCACTAGGTCCGCAGGGAGAAAAAGGTGTTATGGGATATCCAGGTCCTCCTGGGGTTCCAGGACCTATCGGTCCAT
TGGGATTACCTGGTCATGTGGGGGCAAGAGGACCACCTGGGAGTCAAGGTCCTAAAGGACAAAGAGGATCAAGAGGACCAGATGGTCTCT
TAGGGGAACAAGGTATACAAGGTGCCAAGGGTGAAAAAGGAGATCAAGGAAAAAGAGGGCCTCATGGTCTTATTGGTAAGACTGGAAACC
CTGGAGAAAGAGGATTTCAAGGGAAACCAGGTTTACAGGGATTGCCTGGAAGTACAGGTGACAGAGGACTTCCAGGAGAGCCAGGACTGC
GAGGACTGCAAGGTGATGTTGGACCTCCTGGAGAAATGGGCATGGAGGGACCTCCAGGCACTGAGGGAGAGTCTGGTCTGCAAGGTGAAC
CAGGTGCAAAGGGAGATGTTGGAACTGCTGGCAGTGTTGGAGGAACTGGGGAACCAGGTTTACGGGGTGAACCAGGAGCTCCTGGAGAAG
AAGGTCTCCAGGGAAAAGATGGGTTAAAGGGAGTACCAGGAGGAAGGGGACTTCCTGGAGAGGATGGAGAAAAAGGAGAGATGGGCTTAC
CAGGAATTATAGGACCCTTGGGTAGATCAGGCCAAACAGGCCTTCCGGGACCTGAAGGAATTGTGGGAATTCCAGGGCAAAGAGGTCGTC
CAGGAAAAAAGGGTGATAAAGGACAAATAGGACCCACAGGAGAAGTTGGAAGCAGAGGTCCTCCTGGAAAAATTGGGAAAAGTGGTCCTA
AGGGTGCCAGAGGAACTAGAGGTGCTGTGGGACATTTAGGATTGATGGGACCTGATGGAGAACCAGGAATTCCAGGGTACAGGGGCCATC
AGGGCCAACCAGGACCCTCTGGATTGCCAGGACCTAAAGGAGAAAAGGGCTACCCAGGAGAAGATAGCACAGTCCTAGGACCACCTGGGC
CTCGAGGTGAACCAGGTCCAGTGGGGGACCAAGGAGAGAGAGGAGAGCCTGGAGCAGAGGGATATAAGGGCCATGTGGGTGTACCAGGAC
TAAGAGGTGCCACTGGACAACAAGGACCCCCAGGCGAACCAGGTGACCAGGGTGAACAAGGACTAAAAGGAGAGAGAGGATCTGAAGGTA
ATAAGGGGAAAAAAGGAGCTCCTGGTCCTTCTGGGAAACCTGGGATTCCTGGACTTCAAGGCCTACTTGGGCCAAAAGGCATACAAGGAT
ACCATGGAGCAGATGGCATTTCAGGAAACCCTGGAAAAATTGGGCCACCAGGAAAACAGGGACTTCCTGGCATCAGAGGCGGCCCAGGAA
GAACAGGTCTTGCTGGGGCTCCAGGTCCTCCAGGAGTAAAGGGTTCATCAGGCTTGCCAGGAAGCCCAGGAATTCAAGGCCCAAAGGGTG
AACAAGGGCTACCTGGTCAACCTGGAATTCAAGGTAAAAGAGGTCACCGAGGAGCACAAGGTGATCAAGGACCATGTGGAGACCCTGGCC
TGAAAGGGCAGCCTGGAGAATATGGTGTTCAAGGTTTGACAGGTTTCCAAGGATTCCCAGGCCCTAAAGGTCCTGAAGGGGATGCTGGCA
TTGTTGGGATATCAGGTCCTAAAGGTCCTATTGGACACAGAGGAAACACTGGTCCCCTTGGCAGAGAAGGTATAATAGGCCCAACAGGTA
GAACTGGACCCAGAGGTGAAAAGGGCTTTAGAGGTGAAACTGGTCCTCAAGGACCAAGAGGTCAACCAGGGCCTCCAGGTCCACCTGGAG
CACCAGGCCCAAGAAAGCAAATGGATATCAATGCTGCTATTCAAGCCTTGATTGAATCAAATACTGCCCTACAGATGGAGAGCTACCAGA
ATACTGAAGTGACTTTAATTGACCACAGTGAAGAGATATTCAAAACCCTGAACTACCTTAGCAATTTATTGCACAGCATCAAGAATCCTC
TTGGCACACGAGATAACCCAGCACGAATCTGCAAAGATTTACTTAACTGTGAACAAAAAGTATCAGATGGAAAATACTGGATTGACCCAA
ATCTTGGCTGTCCTTCAGATGCCATTGAGGTTTTCTGCAATTTCAGTGCTGGTGGCCAGACATGCTTACCTCCTGTTTCTGTAACAAAGT
TGGAGTTTGGAGTTGGGAAAGTCCAGATGAACTTCCTTCATTTACTGAGTTCGGAAGCCACCCATATCATCACCATTCACTGTCTAAACA
CCCCAAGGTGGACAAGCACACAAACAAGTGGCCCAGGATTGCCTATTGGTTTCAAGGGATGGAATGGCCAGATTTTTAAAGTAAACACTC
TACTTGAACCTAAAGTGCTTTCAGATGACTGCAAGATTCAAGATGGCAGCTGGCATAAGGCAACATTTCTTTTTCACACCCAGGAACCTA
ATCAACTTCCAGTGATTGAAGTACAAAAACTTCCTCATCTCAAAACTGAACGAAAGTATTACATTGACAGCAGTTCTGTATGCTTTCTGT
AAAGTCTCTGAATTAGTTCCGAATTCAGGCTGTTGGCCAGGTAATTGCTGCAGAGGGAGAAATAAGACAGACAGATACAGTCATTATGAA
ATGCATGTAATAAAGCATTGGCTAAATCTTAAAGAATCTCAGGAAGAACAGACTTCCTCCTAAGAAGGAGAAAAGGCATTTTTAAAGGAC
TATGATTGATAAAGTATTTAATTCTTTTAAAAATTATATTCATCTCAGCTTTCTTAGAGAATTCCCTAGAACTAAAAATTTATAAATATG
GAATTCTTCAGGGTATCTTATATTTTTGACTGAGTGCGTAGTACCCATTAGACAGCTGGAGATGCAGAGCACTATGGAGCAATACTGGCT
AATGCTTCCAGATGTGCACTGCTTCTGTCTAAAAATTACAAGCCACAGTCTAATATGTCTTATTTTCCAAAACACTAAGCTGTATTCAGG
TCCCCGATGGGCATATACATCTTAGCCGGTGATACACTACCTCTTACGTGTTGCCTCTTTGTGTTGCTTGGTGCTCTTTCGAAAACAAGG
TGCTTATGGCTTTCATAGACTATTTCCTTTTTCATCTTTGTCATTCTTTAAAAGTGTATGTACTGGTTACATCAAGATATGTTTTGGTTG
TTAGTACTTATTTTAATTTGTTTGGTCACACACTTAATAACACGTGAAACTATTTATGTGAAGTCCTTGTTTTATTTTAAAATTCTCTTT
GTGTATTTGGAATCAAAGCCAGCACATTGTAACCTGTGCTTGTACGCAAAAGAATTAGATTTCTTTGTTTTTGTTTTATTTTTTAAATTG
TTGTAAAAATTATTATAGGCCAGCTACATCTAGTAGTAGGTTTGGGGTACAGATTGGGGGTTGTGCCATACTGTTTTTAAAGTTCATGAT
CATCTGGAATGATACTTAGTGTATATATATTTTGTAAAGTTTTAATTCAGCAAATTTTTTGAAATTGCTGCTGTTTTAAATTATAAAACC
TTTATATTTCTGCTTTGTAGAAATTATATGTTTTGTAGTATTCATTGATTTTCTTTCACTGTACTTAAATTTAGTGTTAGTACTTTAAAA
TTTTTAATTTACCAGTCTTTAAAGCAACATCCAGAAAAAAAAAAGTCTTTTCCCATTTAAAATAGGCTCAGCCAGTTCAATGTCTCCTTG
TTATCAGAGAAATATTAGTTCAATACTGAAAGAAAAATATTATACCTCTTGGTATCTAGAAAAGCTTGTTCATCCATTATAAATATATCT

>65782_65782_1_PKN2-COL24A1_PKN2_chr1_89150311_ENST00000316005_COL24A1_chr1_86453337_ENST00000370571_length(amino acids)=1006AA_BP=62
MRLHESLVVFFFFFLSPLLTPTPSPVPPSPFARGGRVQVRSPYRSAMASNPERGEILLTELQGFPGDIGIPGQNGPEGPKGLLGNRGPPG
PPGLKGTQGEEGPIGAFGELGPRGKPGQKGYAGEPGPEGLKGEVGDQGNIGKIGETGPVGLPGEVGMTGSIGEKGERGSPGPLGPQGEKG
VMGYPGPPGVPGPIGPLGLPGHVGARGPPGSQGPKGQRGSRGPDGLLGEQGIQGAKGEKGDQGKRGPHGLIGKTGNPGERGFQGKPGLQG
LPGSTGDRGLPGEPGLRGLQGDVGPPGEMGMEGPPGTEGESGLQGEPGAKGDVGTAGSVGGTGEPGLRGEPGAPGEEGLQGKDGLKGVPG
GRGLPGEDGEKGEMGLPGIIGPLGRSGQTGLPGPEGIVGIPGQRGRPGKKGDKGQIGPTGEVGSRGPPGKIGKSGPKGARGTRGAVGHLG
LMGPDGEPGIPGYRGHQGQPGPSGLPGPKGEKGYPGEDSTVLGPPGPRGEPGPVGDQGERGEPGAEGYKGHVGVPGLRGATGQQGPPGEP
GDQGEQGLKGERGSEGNKGKKGAPGPSGKPGIPGLQGLLGPKGIQGYHGADGISGNPGKIGPPGKQGLPGIRGGPGRTGLAGAPGPPGVK
GSSGLPGSPGIQGPKGEQGLPGQPGIQGKRGHRGAQGDQGPCGDPGLKGQPGEYGVQGLTGFQGFPGPKGPEGDAGIVGISGPKGPIGHR
GNTGPLGREGIIGPTGRTGPRGEKGFRGETGPQGPRGQPGPPGPPGAPGPRKQMDINAAIQALIESNTALQMESYQNTEVTLIDHSEEIF
KTLNYLSNLLHSIKNPLGTRDNPARICKDLLNCEQKVSDGKYWIDPNLGCPSDAIEVFCNFSAGGQTCLPPVSVTKLEFGVGKVQMNFLH
LLSSEATHIITIHCLNTPRWTSTQTSGPGLPIGFKGWNGQIFKVNTLLEPKVLSDDCKIQDGSWHKATFLFHTQEPNQLPVIEVQKLPHL

--------------------------------------------------------------
>65782_65782_2_PKN2-COL24A1_PKN2_chr1_89150311_ENST00000316005_COL24A1_chr1_86453337_ENST00000436319_length(transcript)=4492nt_BP=407nt
GCTTTTGCGACGCGGTGACAGCCAAATGGTGCGACAGGAGGAGCTGCAGCCGCGGCCGCAGCGCCCGCACGGAGAGGCTTGAGGCGGCTC
CTGGCGTCGCCCAGAGGGAGCGACTAGACGAACAGTCCGGTGAGGGCGGCGAGAGGAAGCCCGCTACGAGTGCCCTAGCTCCCCGCCGCT
CTCGATGAACCGGACGGAATAAGCCGCGCCTCCAGCAGGGGCTGCGCCTCCATGAATCCCTAGTTGTTTTTTTTTTTTTCTTTCTCTCCC
CTCTCCTCACCCCCACCCCGAGCCCCGTCCCGCCTTCTCCCTTCGCCAGAGGCGGCCGCGTCCAGGTGCGGAGTCCATACCGGAGCGCAA
TGGCGTCCAACCCCGAACGGGGGGAGATTCTGCTCACGGAACTGCAGGGTTTTCCAGGAGATATTGGGATTCCTGGACAAAACGGCCCTG
AAGGACCAAAGGGACTCCTTGGAAATAGAGGACCTCCTGGACCTCCTGGTCTCAAAGGAACTCAGGGAGAAGAAGGACCAATTGGAGCCT
TTGGGGAACTGGGGCCAAGAGGAAAACCAGGTCAAAAGGGGTATGCAGGTGAACCAGGACCAGAAGGCTTAAAGGGAGAAGTAGGAGATC
AAGGAAATATTGGAAAAATTGGTGAAACAGGACCTGTTGGCTTACCTGGAGAAGTTGGGATGACTGGAAGCATTGGCGAAAAGGGAGAAC
GTGGAAGTCCAGGCCCACTAGGTCCGCAGGGAGAAAAAGGTGTTATGGGATATCCAGGTCCTCCTGGGGTTCCAGGACCTATCGGTCCAT
TGGGATTACCTGGTCATGTGGGGGCAAGAGGACCACCTGGGAGTCAAGGTCCTAAAGGACAAAGAGGATCAAGAGGACCAGATGGTCTCT
TAGGGGAACAAGGTATACAAGGTGCCAAGGGTGAAAAAGGAGATCAAGGAAAAAGAGGGCCTCATGGTCTTATTGGTAAGACTGGAAACC
CTGGAGAAAGAGGATTTCAAGGGAAACCAGGTTTACAGGGATTGCCTGGAAGTACAGGTGACAGAGGACTTCCAGGAGAGCCAGGACTGC
GAGGACTGCAAGGTGATGTTGGACCTCCTGGAGAAATGGGCATGGAGGGACCTCCAGGCACTGAGGGAGAGTCTGGTCTGCAAGGTGAAC
CAGGTGCAAAGGGAGATGTTGGAACTGCTGGCAGTGTTGGAGGAACTGGGGAACCAGGTTTACGGGGTGAACCAGGAGCTCCTGGAGAAG
AAGGTCTCCAGGGAAAAGATGGGTTAAAGGGAGTACCAGGAGGAAGGGGACTTCCTGGAGAGGATGGAGAAAAAGGAGAGATGGGCTTAC
CAGGAATTATAGGACCCTTGGGTAGATCAGGCCAAACAGGCCTTCCGGGACCTGAAGGAATTGTGGGAATTCCAGGGCAAAGAGGTCGTC
CAGGAAAAAAGGGTGATAAAGGACAAATAGGACCCACAGGAGAAGTTGGAAGCAGAGGTCCTCCTGGAAAAATTGGGAAAAGTGGTCCTA
AGGGTGCCAGAGGAACTAGAGGTGCTGTGGGACATTTAGGATTGATGGGACCTGATGGAGAACCAGGAATTCCAGGGTACAGGGGCCATC
AGGGCCAACCAGGACCCTCTGGATTGCCAGGACCTAAAGGAGAAAAGGGCTACCCAGGAGAAGATAGCACAGTCCTAGGACCACCTGGGC
CTCGAGGTGAACCAGGTCCAGTGGGGGACCAAGGAGAGAGAGGAGAGCCTGGAGCAGAGGGATATAAGGGCCATGTGGGTGTACCAGGAC
TAAGAGGTGCCACTGGACAACAAGGACCCCCAGGCGAACCAGGTGACCAGGGTGAACAAGGACTAAAAGGAGAGAGAGGATCTGAAGGTA
ATAAGGGGAAAAAAGGAGCTCCTGGTCCTTCTGGGAAACCTGGGATTCCTGGACTTCAAGGCCTACTTGGGCCAAAAGGCATACAAGGAT
ACCATGGAGCAGATGGCATTTCAGGAAACCCTGGAAAAATTGGGCCACCAGGAAAACAGGGACTTCCTGGCATCAGAGGCGGCCCAGGAA
GAACAGGTCTTGCTGGGGCTCCAGGTCCTCCAGGAGTAAAGGGTTCATCAGGCTTGCCAGGAAGCCCAGGAATTCAAGGCCCAAAGGGTG
AACAAGGGCTACCTGGTCAACCTGGAATTCAAGGTAAAAGAGGTCACCGAGGAGCACAAGGTGATCAAGGACCATGTGGAGACCCTGGCC
TGAAAGGGCAGCCTGGAGAATATGGTGTTCAAGGTTTGACAGGTTTCCAAGGATTCCCAGGCCCTAAAGGTCCTGAAGGGGATGCTGGCA
TTGTTGGGATATCAGGTCCTAAAGGTCCTATTGGACACAGAGGAAACACTGGTCCCCTTGGCAGAGAAGGTATAATAGGCCCAACAGGTA
GAACTGGACCCAGAGGTGAAAAGGGCTTTAGAGGTGAAACTAAGCAAATGGATATCAATGCTGCTATTCAAGCCTTGATTGAATCAAATA
CTGCCCTACAGATGGAGAGCTACCAGAATACTGAAGTGACTTTAATTGACCACAGTGAAGAGATATTCAAAACCCTGAACTACCTTAGCA
ATTTATTGCACAGCATCAAGAATCCTCTTGGCACACGAGATAACCCAGCACGAATCTGCAAAGATTTACTTAACTGTGAACAAAAAGTAT
CAGATGGAAAATACTGGATTGACCCAAATCTTGGCTGTCCTTCAGATGCCATTGAGGTTTTCTGCAATTTCAGTGCTGGTGGCCAGACAT
GCTTACCTCCTGTTTCTGTAACAAAGTTGGAGTTTGGAGTTGGGAAAGTCCAGATGAACTTCCTTCATTTACTGAGTTCGGAAGCCACCC
ATATCATCACCATTCACTGTCTAAACACCCCAAGGTGGACAAGCACACAAACAAGTGGCCCAGGATTGCCTATTGGTTTCAAGGGATGGA
ATGGCCAGATTTTTAAAGTAAACACTCTACTTGAACCTAAAGTGCTTTCAGATGACTGCAAGATTCAAGATGGCAGCTGGCATAAGGCAA
CATTTCTTTTTCACACCCAGGAACCTAATCAACTTCCAGTGATTGAAGTACAAAAACTTCCTCATCTCAAAACTGAACGAAAGTATTACA
TTGACAGCAGTTCTGTATGCTTTCTGTAAAGTCTCTGAATTAGTTCCGAATTCAGGCTGTTGGCCAGGTAATTGCTGCAGAGGGAGAAAT
AAGACAGACAGATACAGTCATTATGAAATGCATGTAATAAAGCATTGGCTAAATCTTAAAGAATCTCAGGAAGAACAGACTTCCTCCTAA
GAAGGAGAAAAGGCATTTTTAAAGGACTATGATTGATAAAGTATTTAATTCTTTTAAAAATTATATTCATCTCAGCTTTCTTAGAGAATT
CCCTAGAACTAAAAATTTATAAATATGGAATTCTTCAGGGTATCTTATATTTTTGACTGAGTGCGTAGTACCCATTAGACAGCTGGAGAT
GCAGAGCACTATGGAGCAATACTGGCTAATGCTTCCAGATGTGCACTGCTTCTGTCTAAAAATTACAAGCCACAGTCTAATATGTCTTAT
TTTCCAAAACACTAAGCTGTATTCAGGTCCCCGATGGGCATATACATCTTAGCCGGTGATACACTACCTCTTACGTGTTGCCTCTTTGTG
TTGCTTGGTGCTCTTTCGAAAACAAGGTGCTTATGGCTTTCATAGACTATTTCCTTTTTCATCTTTGTCATTCTTTAAAAGTGTATGTAC
TGGTTACATCAAGATATGTTTTGGTTGTTAGTACTTATTTTAATTTGTTTGGTCACACACTTAATAACACGTGAAACTATTTATGTGAAG
TCCTTGTTTTATTTTAAAATTCTCTTTGTGTATTTGGAATCAAAGCCAGCACATTGTAACCTGTGCTTGTACGCAAAAGAATTAGATTTC
TTTGTTTTTGTTTTATTTTTTAAATTGTTGTAAAAATTATTATAGGCCAGCTACATCTAGTAGTAGGTTTGGGGTACAGATTGGGGGTTG
TGCCATACTGTTTTTAAAGTTCATGATCATCTGGAATGATACTTAGTGTATATATATTTTGTAAAGTTTTAATTCAGCAAATTTTTTGAA
ATTGCTGCTGTTTTAAATTATAAAACCTTTATATTTCTGCTTTGTAGAAATTATATGTTTTGTAGTATTCATTGATTTTCTTTCACTGTA
CTTAAATTTAGTGTTAGTACTTTAAAATTTTTAATTTACCAGTCTTTAAAGCAACATCCAGAAAAAAAAAAGTCTTTTCCCATTTAAAAT
AGGCTCAGCCAGTTCAATGTCTCCTTGTTATCAGAGAAATATTAGTTCAATACTGAAAGAAAAATATTATACCTCTTGGTATCTAGAAAA

>65782_65782_2_PKN2-COL24A1_PKN2_chr1_89150311_ENST00000316005_COL24A1_chr1_86453337_ENST00000436319_length(amino acids)=985AA_BP=62
MRLHESLVVFFFFFLSPLLTPTPSPVPPSPFARGGRVQVRSPYRSAMASNPERGEILLTELQGFPGDIGIPGQNGPEGPKGLLGNRGPPG
PPGLKGTQGEEGPIGAFGELGPRGKPGQKGYAGEPGPEGLKGEVGDQGNIGKIGETGPVGLPGEVGMTGSIGEKGERGSPGPLGPQGEKG
VMGYPGPPGVPGPIGPLGLPGHVGARGPPGSQGPKGQRGSRGPDGLLGEQGIQGAKGEKGDQGKRGPHGLIGKTGNPGERGFQGKPGLQG
LPGSTGDRGLPGEPGLRGLQGDVGPPGEMGMEGPPGTEGESGLQGEPGAKGDVGTAGSVGGTGEPGLRGEPGAPGEEGLQGKDGLKGVPG
GRGLPGEDGEKGEMGLPGIIGPLGRSGQTGLPGPEGIVGIPGQRGRPGKKGDKGQIGPTGEVGSRGPPGKIGKSGPKGARGTRGAVGHLG
LMGPDGEPGIPGYRGHQGQPGPSGLPGPKGEKGYPGEDSTVLGPPGPRGEPGPVGDQGERGEPGAEGYKGHVGVPGLRGATGQQGPPGEP
GDQGEQGLKGERGSEGNKGKKGAPGPSGKPGIPGLQGLLGPKGIQGYHGADGISGNPGKIGPPGKQGLPGIRGGPGRTGLAGAPGPPGVK
GSSGLPGSPGIQGPKGEQGLPGQPGIQGKRGHRGAQGDQGPCGDPGLKGQPGEYGVQGLTGFQGFPGPKGPEGDAGIVGISGPKGPIGHR
GNTGPLGREGIIGPTGRTGPRGEKGFRGETKQMDINAAIQALIESNTALQMESYQNTEVTLIDHSEEIFKTLNYLSNLLHSIKNPLGTRD
NPARICKDLLNCEQKVSDGKYWIDPNLGCPSDAIEVFCNFSAGGQTCLPPVSVTKLEFGVGKVQMNFLHLLSSEATHIITIHCLNTPRWT

--------------------------------------------------------------
>65782_65782_3_PKN2-COL24A1_PKN2_chr1_89150311_ENST00000370513_COL24A1_chr1_86453337_ENST00000370571_length(transcript)=4204nt_BP=56nt
GGAGCGCAATGGCGTCCAACCCCGAACGGGGGGAGATTCTGCTCACGGAACTGCAGGGTTTTCCAGGAGATATTGGGATTCCTGGACAAA
ACGGCCCTGAAGGACCAAAGGGACTCCTTGGAAATAGAGGACCTCCTGGACCTCCTGGTCTCAAAGGAACTCAGGGAGAAGAAGGACCAA
TTGGAGCCTTTGGGGAACTGGGGCCAAGAGGAAAACCAGGTCAAAAGGGGTATGCAGGTGAACCAGGACCAGAAGGCTTAAAGGGAGAAG
TAGGAGATCAAGGAAATATTGGAAAAATTGGTGAAACAGGACCTGTTGGCTTACCTGGAGAAGTTGGGATGACTGGAAGCATTGGCGAAA
AGGGAGAACGTGGAAGTCCAGGCCCACTAGGTCCGCAGGGAGAAAAAGGTGTTATGGGATATCCAGGTCCTCCTGGGGTTCCAGGACCTA
TCGGTCCATTGGGATTACCTGGTCATGTGGGGGCAAGAGGACCACCTGGGAGTCAAGGTCCTAAAGGACAAAGAGGATCAAGAGGACCAG
ATGGTCTCTTAGGGGAACAAGGTATACAAGGTGCCAAGGGTGAAAAAGGAGATCAAGGAAAAAGAGGGCCTCATGGTCTTATTGGTAAGA
CTGGAAACCCTGGAGAAAGAGGATTTCAAGGGAAACCAGGTTTACAGGGATTGCCTGGAAGTACAGGTGACAGAGGACTTCCAGGAGAGC
CAGGACTGCGAGGACTGCAAGGTGATGTTGGACCTCCTGGAGAAATGGGCATGGAGGGACCTCCAGGCACTGAGGGAGAGTCTGGTCTGC
AAGGTGAACCAGGTGCAAAGGGAGATGTTGGAACTGCTGGCAGTGTTGGAGGAACTGGGGAACCAGGTTTACGGGGTGAACCAGGAGCTC
CTGGAGAAGAAGGTCTCCAGGGAAAAGATGGGTTAAAGGGAGTACCAGGAGGAAGGGGACTTCCTGGAGAGGATGGAGAAAAAGGAGAGA
TGGGCTTACCAGGAATTATAGGACCCTTGGGTAGATCAGGCCAAACAGGCCTTCCGGGACCTGAAGGAATTGTGGGAATTCCAGGGCAAA
GAGGTCGTCCAGGAAAAAAGGGTGATAAAGGACAAATAGGACCCACAGGAGAAGTTGGAAGCAGAGGTCCTCCTGGAAAAATTGGGAAAA
GTGGTCCTAAGGGTGCCAGAGGAACTAGAGGTGCTGTGGGACATTTAGGATTGATGGGACCTGATGGAGAACCAGGAATTCCAGGGTACA
GGGGCCATCAGGGCCAACCAGGACCCTCTGGATTGCCAGGACCTAAAGGAGAAAAGGGCTACCCAGGAGAAGATAGCACAGTCCTAGGAC
CACCTGGGCCTCGAGGTGAACCAGGTCCAGTGGGGGACCAAGGAGAGAGAGGAGAGCCTGGAGCAGAGGGATATAAGGGCCATGTGGGTG
TACCAGGACTAAGAGGTGCCACTGGACAACAAGGACCCCCAGGCGAACCAGGTGACCAGGGTGAACAAGGACTAAAAGGAGAGAGAGGAT
CTGAAGGTAATAAGGGGAAAAAAGGAGCTCCTGGTCCTTCTGGGAAACCTGGGATTCCTGGACTTCAAGGCCTACTTGGGCCAAAAGGCA
TACAAGGATACCATGGAGCAGATGGCATTTCAGGAAACCCTGGAAAAATTGGGCCACCAGGAAAACAGGGACTTCCTGGCATCAGAGGCG
GCCCAGGAAGAACAGGTCTTGCTGGGGCTCCAGGTCCTCCAGGAGTAAAGGGTTCATCAGGCTTGCCAGGAAGCCCAGGAATTCAAGGCC
CAAAGGGTGAACAAGGGCTACCTGGTCAACCTGGAATTCAAGGTAAAAGAGGTCACCGAGGAGCACAAGGTGATCAAGGACCATGTGGAG
ACCCTGGCCTGAAAGGGCAGCCTGGAGAATATGGTGTTCAAGGTTTGACAGGTTTCCAAGGATTCCCAGGCCCTAAAGGTCCTGAAGGGG
ATGCTGGCATTGTTGGGATATCAGGTCCTAAAGGTCCTATTGGACACAGAGGAAACACTGGTCCCCTTGGCAGAGAAGGTATAATAGGCC
CAACAGGTAGAACTGGACCCAGAGGTGAAAAGGGCTTTAGAGGTGAAACTGGTCCTCAAGGACCAAGAGGTCAACCAGGGCCTCCAGGTC
CACCTGGAGCACCAGGCCCAAGAAAGCAAATGGATATCAATGCTGCTATTCAAGCCTTGATTGAATCAAATACTGCCCTACAGATGGAGA
GCTACCAGAATACTGAAGTGACTTTAATTGACCACAGTGAAGAGATATTCAAAACCCTGAACTACCTTAGCAATTTATTGCACAGCATCA
AGAATCCTCTTGGCACACGAGATAACCCAGCACGAATCTGCAAAGATTTACTTAACTGTGAACAAAAAGTATCAGATGGAAAATACTGGA
TTGACCCAAATCTTGGCTGTCCTTCAGATGCCATTGAGGTTTTCTGCAATTTCAGTGCTGGTGGCCAGACATGCTTACCTCCTGTTTCTG
TAACAAAGTTGGAGTTTGGAGTTGGGAAAGTCCAGATGAACTTCCTTCATTTACTGAGTTCGGAAGCCACCCATATCATCACCATTCACT
GTCTAAACACCCCAAGGTGGACAAGCACACAAACAAGTGGCCCAGGATTGCCTATTGGTTTCAAGGGATGGAATGGCCAGATTTTTAAAG
TAAACACTCTACTTGAACCTAAAGTGCTTTCAGATGACTGCAAGATTCAAGATGGCAGCTGGCATAAGGCAACATTTCTTTTTCACACCC
AGGAACCTAATCAACTTCCAGTGATTGAAGTACAAAAACTTCCTCATCTCAAAACTGAACGAAAGTATTACATTGACAGCAGTTCTGTAT
GCTTTCTGTAAAGTCTCTGAATTAGTTCCGAATTCAGGCTGTTGGCCAGGTAATTGCTGCAGAGGGAGAAATAAGACAGACAGATACAGT
CATTATGAAATGCATGTAATAAAGCATTGGCTAAATCTTAAAGAATCTCAGGAAGAACAGACTTCCTCCTAAGAAGGAGAAAAGGCATTT
TTAAAGGACTATGATTGATAAAGTATTTAATTCTTTTAAAAATTATATTCATCTCAGCTTTCTTAGAGAATTCCCTAGAACTAAAAATTT
ATAAATATGGAATTCTTCAGGGTATCTTATATTTTTGACTGAGTGCGTAGTACCCATTAGACAGCTGGAGATGCAGAGCACTATGGAGCA
ATACTGGCTAATGCTTCCAGATGTGCACTGCTTCTGTCTAAAAATTACAAGCCACAGTCTAATATGTCTTATTTTCCAAAACACTAAGCT
GTATTCAGGTCCCCGATGGGCATATACATCTTAGCCGGTGATACACTACCTCTTACGTGTTGCCTCTTTGTGTTGCTTGGTGCTCTTTCG
AAAACAAGGTGCTTATGGCTTTCATAGACTATTTCCTTTTTCATCTTTGTCATTCTTTAAAAGTGTATGTACTGGTTACATCAAGATATG
TTTTGGTTGTTAGTACTTATTTTAATTTGTTTGGTCACACACTTAATAACACGTGAAACTATTTATGTGAAGTCCTTGTTTTATTTTAAA
ATTCTCTTTGTGTATTTGGAATCAAAGCCAGCACATTGTAACCTGTGCTTGTACGCAAAAGAATTAGATTTCTTTGTTTTTGTTTTATTT
TTTAAATTGTTGTAAAAATTATTATAGGCCAGCTACATCTAGTAGTAGGTTTGGGGTACAGATTGGGGGTTGTGCCATACTGTTTTTAAA
GTTCATGATCATCTGGAATGATACTTAGTGTATATATATTTTGTAAAGTTTTAATTCAGCAAATTTTTTGAAATTGCTGCTGTTTTAAAT
TATAAAACCTTTATATTTCTGCTTTGTAGAAATTATATGTTTTGTAGTATTCATTGATTTTCTTTCACTGTACTTAAATTTAGTGTTAGT
ACTTTAAAATTTTTAATTTACCAGTCTTTAAAGCAACATCCAGAAAAAAAAAAGTCTTTTCCCATTTAAAATAGGCTCAGCCAGTTCAAT
GTCTCCTTGTTATCAGAGAAATATTAGTTCAATACTGAAAGAAAAATATTATACCTCTTGGTATCTAGAAAAGCTTGTTCATCCATTATA

>65782_65782_3_PKN2-COL24A1_PKN2_chr1_89150311_ENST00000370513_COL24A1_chr1_86453337_ENST00000370571_length(amino acids)=960AA_BP=16
MASNPERGEILLTELQGFPGDIGIPGQNGPEGPKGLLGNRGPPGPPGLKGTQGEEGPIGAFGELGPRGKPGQKGYAGEPGPEGLKGEVGD
QGNIGKIGETGPVGLPGEVGMTGSIGEKGERGSPGPLGPQGEKGVMGYPGPPGVPGPIGPLGLPGHVGARGPPGSQGPKGQRGSRGPDGL
LGEQGIQGAKGEKGDQGKRGPHGLIGKTGNPGERGFQGKPGLQGLPGSTGDRGLPGEPGLRGLQGDVGPPGEMGMEGPPGTEGESGLQGE
PGAKGDVGTAGSVGGTGEPGLRGEPGAPGEEGLQGKDGLKGVPGGRGLPGEDGEKGEMGLPGIIGPLGRSGQTGLPGPEGIVGIPGQRGR
PGKKGDKGQIGPTGEVGSRGPPGKIGKSGPKGARGTRGAVGHLGLMGPDGEPGIPGYRGHQGQPGPSGLPGPKGEKGYPGEDSTVLGPPG
PRGEPGPVGDQGERGEPGAEGYKGHVGVPGLRGATGQQGPPGEPGDQGEQGLKGERGSEGNKGKKGAPGPSGKPGIPGLQGLLGPKGIQG
YHGADGISGNPGKIGPPGKQGLPGIRGGPGRTGLAGAPGPPGVKGSSGLPGSPGIQGPKGEQGLPGQPGIQGKRGHRGAQGDQGPCGDPG
LKGQPGEYGVQGLTGFQGFPGPKGPEGDAGIVGISGPKGPIGHRGNTGPLGREGIIGPTGRTGPRGEKGFRGETGPQGPRGQPGPPGPPG
APGPRKQMDINAAIQALIESNTALQMESYQNTEVTLIDHSEEIFKTLNYLSNLLHSIKNPLGTRDNPARICKDLLNCEQKVSDGKYWIDP
NLGCPSDAIEVFCNFSAGGQTCLPPVSVTKLEFGVGKVQMNFLHLLSSEATHIITIHCLNTPRWTSTQTSGPGLPIGFKGWNGQIFKVNT

--------------------------------------------------------------
>65782_65782_4_PKN2-COL24A1_PKN2_chr1_89150311_ENST00000370513_COL24A1_chr1_86453337_ENST00000436319_length(transcript)=4141nt_BP=56nt
GGAGCGCAATGGCGTCCAACCCCGAACGGGGGGAGATTCTGCTCACGGAACTGCAGGGTTTTCCAGGAGATATTGGGATTCCTGGACAAA
ACGGCCCTGAAGGACCAAAGGGACTCCTTGGAAATAGAGGACCTCCTGGACCTCCTGGTCTCAAAGGAACTCAGGGAGAAGAAGGACCAA
TTGGAGCCTTTGGGGAACTGGGGCCAAGAGGAAAACCAGGTCAAAAGGGGTATGCAGGTGAACCAGGACCAGAAGGCTTAAAGGGAGAAG
TAGGAGATCAAGGAAATATTGGAAAAATTGGTGAAACAGGACCTGTTGGCTTACCTGGAGAAGTTGGGATGACTGGAAGCATTGGCGAAA
AGGGAGAACGTGGAAGTCCAGGCCCACTAGGTCCGCAGGGAGAAAAAGGTGTTATGGGATATCCAGGTCCTCCTGGGGTTCCAGGACCTA
TCGGTCCATTGGGATTACCTGGTCATGTGGGGGCAAGAGGACCACCTGGGAGTCAAGGTCCTAAAGGACAAAGAGGATCAAGAGGACCAG
ATGGTCTCTTAGGGGAACAAGGTATACAAGGTGCCAAGGGTGAAAAAGGAGATCAAGGAAAAAGAGGGCCTCATGGTCTTATTGGTAAGA
CTGGAAACCCTGGAGAAAGAGGATTTCAAGGGAAACCAGGTTTACAGGGATTGCCTGGAAGTACAGGTGACAGAGGACTTCCAGGAGAGC
CAGGACTGCGAGGACTGCAAGGTGATGTTGGACCTCCTGGAGAAATGGGCATGGAGGGACCTCCAGGCACTGAGGGAGAGTCTGGTCTGC
AAGGTGAACCAGGTGCAAAGGGAGATGTTGGAACTGCTGGCAGTGTTGGAGGAACTGGGGAACCAGGTTTACGGGGTGAACCAGGAGCTC
CTGGAGAAGAAGGTCTCCAGGGAAAAGATGGGTTAAAGGGAGTACCAGGAGGAAGGGGACTTCCTGGAGAGGATGGAGAAAAAGGAGAGA
TGGGCTTACCAGGAATTATAGGACCCTTGGGTAGATCAGGCCAAACAGGCCTTCCGGGACCTGAAGGAATTGTGGGAATTCCAGGGCAAA
GAGGTCGTCCAGGAAAAAAGGGTGATAAAGGACAAATAGGACCCACAGGAGAAGTTGGAAGCAGAGGTCCTCCTGGAAAAATTGGGAAAA
GTGGTCCTAAGGGTGCCAGAGGAACTAGAGGTGCTGTGGGACATTTAGGATTGATGGGACCTGATGGAGAACCAGGAATTCCAGGGTACA
GGGGCCATCAGGGCCAACCAGGACCCTCTGGATTGCCAGGACCTAAAGGAGAAAAGGGCTACCCAGGAGAAGATAGCACAGTCCTAGGAC
CACCTGGGCCTCGAGGTGAACCAGGTCCAGTGGGGGACCAAGGAGAGAGAGGAGAGCCTGGAGCAGAGGGATATAAGGGCCATGTGGGTG
TACCAGGACTAAGAGGTGCCACTGGACAACAAGGACCCCCAGGCGAACCAGGTGACCAGGGTGAACAAGGACTAAAAGGAGAGAGAGGAT
CTGAAGGTAATAAGGGGAAAAAAGGAGCTCCTGGTCCTTCTGGGAAACCTGGGATTCCTGGACTTCAAGGCCTACTTGGGCCAAAAGGCA
TACAAGGATACCATGGAGCAGATGGCATTTCAGGAAACCCTGGAAAAATTGGGCCACCAGGAAAACAGGGACTTCCTGGCATCAGAGGCG
GCCCAGGAAGAACAGGTCTTGCTGGGGCTCCAGGTCCTCCAGGAGTAAAGGGTTCATCAGGCTTGCCAGGAAGCCCAGGAATTCAAGGCC
CAAAGGGTGAACAAGGGCTACCTGGTCAACCTGGAATTCAAGGTAAAAGAGGTCACCGAGGAGCACAAGGTGATCAAGGACCATGTGGAG
ACCCTGGCCTGAAAGGGCAGCCTGGAGAATATGGTGTTCAAGGTTTGACAGGTTTCCAAGGATTCCCAGGCCCTAAAGGTCCTGAAGGGG
ATGCTGGCATTGTTGGGATATCAGGTCCTAAAGGTCCTATTGGACACAGAGGAAACACTGGTCCCCTTGGCAGAGAAGGTATAATAGGCC
CAACAGGTAGAACTGGACCCAGAGGTGAAAAGGGCTTTAGAGGTGAAACTAAGCAAATGGATATCAATGCTGCTATTCAAGCCTTGATTG
AATCAAATACTGCCCTACAGATGGAGAGCTACCAGAATACTGAAGTGACTTTAATTGACCACAGTGAAGAGATATTCAAAACCCTGAACT
ACCTTAGCAATTTATTGCACAGCATCAAGAATCCTCTTGGCACACGAGATAACCCAGCACGAATCTGCAAAGATTTACTTAACTGTGAAC
AAAAAGTATCAGATGGAAAATACTGGATTGACCCAAATCTTGGCTGTCCTTCAGATGCCATTGAGGTTTTCTGCAATTTCAGTGCTGGTG
GCCAGACATGCTTACCTCCTGTTTCTGTAACAAAGTTGGAGTTTGGAGTTGGGAAAGTCCAGATGAACTTCCTTCATTTACTGAGTTCGG
AAGCCACCCATATCATCACCATTCACTGTCTAAACACCCCAAGGTGGACAAGCACACAAACAAGTGGCCCAGGATTGCCTATTGGTTTCA
AGGGATGGAATGGCCAGATTTTTAAAGTAAACACTCTACTTGAACCTAAAGTGCTTTCAGATGACTGCAAGATTCAAGATGGCAGCTGGC
ATAAGGCAACATTTCTTTTTCACACCCAGGAACCTAATCAACTTCCAGTGATTGAAGTACAAAAACTTCCTCATCTCAAAACTGAACGAA
AGTATTACATTGACAGCAGTTCTGTATGCTTTCTGTAAAGTCTCTGAATTAGTTCCGAATTCAGGCTGTTGGCCAGGTAATTGCTGCAGA
GGGAGAAATAAGACAGACAGATACAGTCATTATGAAATGCATGTAATAAAGCATTGGCTAAATCTTAAAGAATCTCAGGAAGAACAGACT
TCCTCCTAAGAAGGAGAAAAGGCATTTTTAAAGGACTATGATTGATAAAGTATTTAATTCTTTTAAAAATTATATTCATCTCAGCTTTCT
TAGAGAATTCCCTAGAACTAAAAATTTATAAATATGGAATTCTTCAGGGTATCTTATATTTTTGACTGAGTGCGTAGTACCCATTAGACA
GCTGGAGATGCAGAGCACTATGGAGCAATACTGGCTAATGCTTCCAGATGTGCACTGCTTCTGTCTAAAAATTACAAGCCACAGTCTAAT
ATGTCTTATTTTCCAAAACACTAAGCTGTATTCAGGTCCCCGATGGGCATATACATCTTAGCCGGTGATACACTACCTCTTACGTGTTGC
CTCTTTGTGTTGCTTGGTGCTCTTTCGAAAACAAGGTGCTTATGGCTTTCATAGACTATTTCCTTTTTCATCTTTGTCATTCTTTAAAAG
TGTATGTACTGGTTACATCAAGATATGTTTTGGTTGTTAGTACTTATTTTAATTTGTTTGGTCACACACTTAATAACACGTGAAACTATT
TATGTGAAGTCCTTGTTTTATTTTAAAATTCTCTTTGTGTATTTGGAATCAAAGCCAGCACATTGTAACCTGTGCTTGTACGCAAAAGAA
TTAGATTTCTTTGTTTTTGTTTTATTTTTTAAATTGTTGTAAAAATTATTATAGGCCAGCTACATCTAGTAGTAGGTTTGGGGTACAGAT
TGGGGGTTGTGCCATACTGTTTTTAAAGTTCATGATCATCTGGAATGATACTTAGTGTATATATATTTTGTAAAGTTTTAATTCAGCAAA
TTTTTTGAAATTGCTGCTGTTTTAAATTATAAAACCTTTATATTTCTGCTTTGTAGAAATTATATGTTTTGTAGTATTCATTGATTTTCT
TTCACTGTACTTAAATTTAGTGTTAGTACTTTAAAATTTTTAATTTACCAGTCTTTAAAGCAACATCCAGAAAAAAAAAAGTCTTTTCCC
ATTTAAAATAGGCTCAGCCAGTTCAATGTCTCCTTGTTATCAGAGAAATATTAGTTCAATACTGAAAGAAAAATATTATACCTCTTGGTA
TCTAGAAAAGCTTGTTCATCCATTATAAATATATCTTTAGCCACAGCAAACCACACTTAACCTATCTATAATAAAAATGTGCTTTAAATA

>65782_65782_4_PKN2-COL24A1_PKN2_chr1_89150311_ENST00000370513_COL24A1_chr1_86453337_ENST00000436319_length(amino acids)=939AA_BP=16
MASNPERGEILLTELQGFPGDIGIPGQNGPEGPKGLLGNRGPPGPPGLKGTQGEEGPIGAFGELGPRGKPGQKGYAGEPGPEGLKGEVGD
QGNIGKIGETGPVGLPGEVGMTGSIGEKGERGSPGPLGPQGEKGVMGYPGPPGVPGPIGPLGLPGHVGARGPPGSQGPKGQRGSRGPDGL
LGEQGIQGAKGEKGDQGKRGPHGLIGKTGNPGERGFQGKPGLQGLPGSTGDRGLPGEPGLRGLQGDVGPPGEMGMEGPPGTEGESGLQGE
PGAKGDVGTAGSVGGTGEPGLRGEPGAPGEEGLQGKDGLKGVPGGRGLPGEDGEKGEMGLPGIIGPLGRSGQTGLPGPEGIVGIPGQRGR
PGKKGDKGQIGPTGEVGSRGPPGKIGKSGPKGARGTRGAVGHLGLMGPDGEPGIPGYRGHQGQPGPSGLPGPKGEKGYPGEDSTVLGPPG
PRGEPGPVGDQGERGEPGAEGYKGHVGVPGLRGATGQQGPPGEPGDQGEQGLKGERGSEGNKGKKGAPGPSGKPGIPGLQGLLGPKGIQG
YHGADGISGNPGKIGPPGKQGLPGIRGGPGRTGLAGAPGPPGVKGSSGLPGSPGIQGPKGEQGLPGQPGIQGKRGHRGAQGDQGPCGDPG
LKGQPGEYGVQGLTGFQGFPGPKGPEGDAGIVGISGPKGPIGHRGNTGPLGREGIIGPTGRTGPRGEKGFRGETKQMDINAAIQALIESN
TALQMESYQNTEVTLIDHSEEIFKTLNYLSNLLHSIKNPLGTRDNPARICKDLLNCEQKVSDGKYWIDPNLGCPSDAIEVFCNFSAGGQT
CLPPVSVTKLEFGVGKVQMNFLHLLSSEATHIITIHCLNTPRWTSTQTSGPGLPIGFKGWNGQIFKVNTLLEPKVLSDDCKIQDGSWHKA

--------------------------------------------------------------
>65782_65782_5_PKN2-COL24A1_PKN2_chr1_89150311_ENST00000370521_COL24A1_chr1_86453337_ENST00000370571_length(transcript)=4555nt_BP=407nt
GCTTTTGCGACGCGGTGACAGCCAAATGGTGCGACAGGAGGAGCTGCAGCCGCGGCCGCAGCGCCCGCACGGAGAGGCTTGAGGCGGCTC
CTGGCGTCGCCCAGAGGGAGCGACTAGACGAACAGTCCGGTGAGGGCGGCGAGAGGAAGCCCGCTACGAGTGCCCTAGCTCCCCGCCGCT
CTCGATGAACCGGACGGAATAAGCCGCGCCTCCAGCAGGGGCTGCGCCTCCATGAATCCCTAGTTGTTTTTTTTTTTTTCTTTCTCTCCC
CTCTCCTCACCCCCACCCCGAGCCCCGTCCCGCCTTCTCCCTTCGCCAGAGGCGGCCGCGTCCAGGTGCGGAGTCCATACCGGAGCGCAA
TGGCGTCCAACCCCGAACGGGGGGAGATTCTGCTCACGGAACTGCAGGGTTTTCCAGGAGATATTGGGATTCCTGGACAAAACGGCCCTG
AAGGACCAAAGGGACTCCTTGGAAATAGAGGACCTCCTGGACCTCCTGGTCTCAAAGGAACTCAGGGAGAAGAAGGACCAATTGGAGCCT
TTGGGGAACTGGGGCCAAGAGGAAAACCAGGTCAAAAGGGGTATGCAGGTGAACCAGGACCAGAAGGCTTAAAGGGAGAAGTAGGAGATC
AAGGAAATATTGGAAAAATTGGTGAAACAGGACCTGTTGGCTTACCTGGAGAAGTTGGGATGACTGGAAGCATTGGCGAAAAGGGAGAAC
GTGGAAGTCCAGGCCCACTAGGTCCGCAGGGAGAAAAAGGTGTTATGGGATATCCAGGTCCTCCTGGGGTTCCAGGACCTATCGGTCCAT
TGGGATTACCTGGTCATGTGGGGGCAAGAGGACCACCTGGGAGTCAAGGTCCTAAAGGACAAAGAGGATCAAGAGGACCAGATGGTCTCT
TAGGGGAACAAGGTATACAAGGTGCCAAGGGTGAAAAAGGAGATCAAGGAAAAAGAGGGCCTCATGGTCTTATTGGTAAGACTGGAAACC
CTGGAGAAAGAGGATTTCAAGGGAAACCAGGTTTACAGGGATTGCCTGGAAGTACAGGTGACAGAGGACTTCCAGGAGAGCCAGGACTGC
GAGGACTGCAAGGTGATGTTGGACCTCCTGGAGAAATGGGCATGGAGGGACCTCCAGGCACTGAGGGAGAGTCTGGTCTGCAAGGTGAAC
CAGGTGCAAAGGGAGATGTTGGAACTGCTGGCAGTGTTGGAGGAACTGGGGAACCAGGTTTACGGGGTGAACCAGGAGCTCCTGGAGAAG
AAGGTCTCCAGGGAAAAGATGGGTTAAAGGGAGTACCAGGAGGAAGGGGACTTCCTGGAGAGGATGGAGAAAAAGGAGAGATGGGCTTAC
CAGGAATTATAGGACCCTTGGGTAGATCAGGCCAAACAGGCCTTCCGGGACCTGAAGGAATTGTGGGAATTCCAGGGCAAAGAGGTCGTC
CAGGAAAAAAGGGTGATAAAGGACAAATAGGACCCACAGGAGAAGTTGGAAGCAGAGGTCCTCCTGGAAAAATTGGGAAAAGTGGTCCTA
AGGGTGCCAGAGGAACTAGAGGTGCTGTGGGACATTTAGGATTGATGGGACCTGATGGAGAACCAGGAATTCCAGGGTACAGGGGCCATC
AGGGCCAACCAGGACCCTCTGGATTGCCAGGACCTAAAGGAGAAAAGGGCTACCCAGGAGAAGATAGCACAGTCCTAGGACCACCTGGGC
CTCGAGGTGAACCAGGTCCAGTGGGGGACCAAGGAGAGAGAGGAGAGCCTGGAGCAGAGGGATATAAGGGCCATGTGGGTGTACCAGGAC
TAAGAGGTGCCACTGGACAACAAGGACCCCCAGGCGAACCAGGTGACCAGGGTGAACAAGGACTAAAAGGAGAGAGAGGATCTGAAGGTA
ATAAGGGGAAAAAAGGAGCTCCTGGTCCTTCTGGGAAACCTGGGATTCCTGGACTTCAAGGCCTACTTGGGCCAAAAGGCATACAAGGAT
ACCATGGAGCAGATGGCATTTCAGGAAACCCTGGAAAAATTGGGCCACCAGGAAAACAGGGACTTCCTGGCATCAGAGGCGGCCCAGGAA
GAACAGGTCTTGCTGGGGCTCCAGGTCCTCCAGGAGTAAAGGGTTCATCAGGCTTGCCAGGAAGCCCAGGAATTCAAGGCCCAAAGGGTG
AACAAGGGCTACCTGGTCAACCTGGAATTCAAGGTAAAAGAGGTCACCGAGGAGCACAAGGTGATCAAGGACCATGTGGAGACCCTGGCC
TGAAAGGGCAGCCTGGAGAATATGGTGTTCAAGGTTTGACAGGTTTCCAAGGATTCCCAGGCCCTAAAGGTCCTGAAGGGGATGCTGGCA
TTGTTGGGATATCAGGTCCTAAAGGTCCTATTGGACACAGAGGAAACACTGGTCCCCTTGGCAGAGAAGGTATAATAGGCCCAACAGGTA
GAACTGGACCCAGAGGTGAAAAGGGCTTTAGAGGTGAAACTGGTCCTCAAGGACCAAGAGGTCAACCAGGGCCTCCAGGTCCACCTGGAG
CACCAGGCCCAAGAAAGCAAATGGATATCAATGCTGCTATTCAAGCCTTGATTGAATCAAATACTGCCCTACAGATGGAGAGCTACCAGA
ATACTGAAGTGACTTTAATTGACCACAGTGAAGAGATATTCAAAACCCTGAACTACCTTAGCAATTTATTGCACAGCATCAAGAATCCTC
TTGGCACACGAGATAACCCAGCACGAATCTGCAAAGATTTACTTAACTGTGAACAAAAAGTATCAGATGGAAAATACTGGATTGACCCAA
ATCTTGGCTGTCCTTCAGATGCCATTGAGGTTTTCTGCAATTTCAGTGCTGGTGGCCAGACATGCTTACCTCCTGTTTCTGTAACAAAGT
TGGAGTTTGGAGTTGGGAAAGTCCAGATGAACTTCCTTCATTTACTGAGTTCGGAAGCCACCCATATCATCACCATTCACTGTCTAAACA
CCCCAAGGTGGACAAGCACACAAACAAGTGGCCCAGGATTGCCTATTGGTTTCAAGGGATGGAATGGCCAGATTTTTAAAGTAAACACTC
TACTTGAACCTAAAGTGCTTTCAGATGACTGCAAGATTCAAGATGGCAGCTGGCATAAGGCAACATTTCTTTTTCACACCCAGGAACCTA
ATCAACTTCCAGTGATTGAAGTACAAAAACTTCCTCATCTCAAAACTGAACGAAAGTATTACATTGACAGCAGTTCTGTATGCTTTCTGT
AAAGTCTCTGAATTAGTTCCGAATTCAGGCTGTTGGCCAGGTAATTGCTGCAGAGGGAGAAATAAGACAGACAGATACAGTCATTATGAA
ATGCATGTAATAAAGCATTGGCTAAATCTTAAAGAATCTCAGGAAGAACAGACTTCCTCCTAAGAAGGAGAAAAGGCATTTTTAAAGGAC
TATGATTGATAAAGTATTTAATTCTTTTAAAAATTATATTCATCTCAGCTTTCTTAGAGAATTCCCTAGAACTAAAAATTTATAAATATG
GAATTCTTCAGGGTATCTTATATTTTTGACTGAGTGCGTAGTACCCATTAGACAGCTGGAGATGCAGAGCACTATGGAGCAATACTGGCT
AATGCTTCCAGATGTGCACTGCTTCTGTCTAAAAATTACAAGCCACAGTCTAATATGTCTTATTTTCCAAAACACTAAGCTGTATTCAGG
TCCCCGATGGGCATATACATCTTAGCCGGTGATACACTACCTCTTACGTGTTGCCTCTTTGTGTTGCTTGGTGCTCTTTCGAAAACAAGG
TGCTTATGGCTTTCATAGACTATTTCCTTTTTCATCTTTGTCATTCTTTAAAAGTGTATGTACTGGTTACATCAAGATATGTTTTGGTTG
TTAGTACTTATTTTAATTTGTTTGGTCACACACTTAATAACACGTGAAACTATTTATGTGAAGTCCTTGTTTTATTTTAAAATTCTCTTT
GTGTATTTGGAATCAAAGCCAGCACATTGTAACCTGTGCTTGTACGCAAAAGAATTAGATTTCTTTGTTTTTGTTTTATTTTTTAAATTG
TTGTAAAAATTATTATAGGCCAGCTACATCTAGTAGTAGGTTTGGGGTACAGATTGGGGGTTGTGCCATACTGTTTTTAAAGTTCATGAT
CATCTGGAATGATACTTAGTGTATATATATTTTGTAAAGTTTTAATTCAGCAAATTTTTTGAAATTGCTGCTGTTTTAAATTATAAAACC
TTTATATTTCTGCTTTGTAGAAATTATATGTTTTGTAGTATTCATTGATTTTCTTTCACTGTACTTAAATTTAGTGTTAGTACTTTAAAA
TTTTTAATTTACCAGTCTTTAAAGCAACATCCAGAAAAAAAAAAGTCTTTTCCCATTTAAAATAGGCTCAGCCAGTTCAATGTCTCCTTG
TTATCAGAGAAATATTAGTTCAATACTGAAAGAAAAATATTATACCTCTTGGTATCTAGAAAAGCTTGTTCATCCATTATAAATATATCT

>65782_65782_5_PKN2-COL24A1_PKN2_chr1_89150311_ENST00000370521_COL24A1_chr1_86453337_ENST00000370571_length(amino acids)=1006AA_BP=62
MRLHESLVVFFFFFLSPLLTPTPSPVPPSPFARGGRVQVRSPYRSAMASNPERGEILLTELQGFPGDIGIPGQNGPEGPKGLLGNRGPPG
PPGLKGTQGEEGPIGAFGELGPRGKPGQKGYAGEPGPEGLKGEVGDQGNIGKIGETGPVGLPGEVGMTGSIGEKGERGSPGPLGPQGEKG
VMGYPGPPGVPGPIGPLGLPGHVGARGPPGSQGPKGQRGSRGPDGLLGEQGIQGAKGEKGDQGKRGPHGLIGKTGNPGERGFQGKPGLQG
LPGSTGDRGLPGEPGLRGLQGDVGPPGEMGMEGPPGTEGESGLQGEPGAKGDVGTAGSVGGTGEPGLRGEPGAPGEEGLQGKDGLKGVPG
GRGLPGEDGEKGEMGLPGIIGPLGRSGQTGLPGPEGIVGIPGQRGRPGKKGDKGQIGPTGEVGSRGPPGKIGKSGPKGARGTRGAVGHLG
LMGPDGEPGIPGYRGHQGQPGPSGLPGPKGEKGYPGEDSTVLGPPGPRGEPGPVGDQGERGEPGAEGYKGHVGVPGLRGATGQQGPPGEP
GDQGEQGLKGERGSEGNKGKKGAPGPSGKPGIPGLQGLLGPKGIQGYHGADGISGNPGKIGPPGKQGLPGIRGGPGRTGLAGAPGPPGVK
GSSGLPGSPGIQGPKGEQGLPGQPGIQGKRGHRGAQGDQGPCGDPGLKGQPGEYGVQGLTGFQGFPGPKGPEGDAGIVGISGPKGPIGHR
GNTGPLGREGIIGPTGRTGPRGEKGFRGETGPQGPRGQPGPPGPPGAPGPRKQMDINAAIQALIESNTALQMESYQNTEVTLIDHSEEIF
KTLNYLSNLLHSIKNPLGTRDNPARICKDLLNCEQKVSDGKYWIDPNLGCPSDAIEVFCNFSAGGQTCLPPVSVTKLEFGVGKVQMNFLH
LLSSEATHIITIHCLNTPRWTSTQTSGPGLPIGFKGWNGQIFKVNTLLEPKVLSDDCKIQDGSWHKATFLFHTQEPNQLPVIEVQKLPHL

--------------------------------------------------------------
>65782_65782_6_PKN2-COL24A1_PKN2_chr1_89150311_ENST00000370521_COL24A1_chr1_86453337_ENST00000436319_length(transcript)=4492nt_BP=407nt
GCTTTTGCGACGCGGTGACAGCCAAATGGTGCGACAGGAGGAGCTGCAGCCGCGGCCGCAGCGCCCGCACGGAGAGGCTTGAGGCGGCTC
CTGGCGTCGCCCAGAGGGAGCGACTAGACGAACAGTCCGGTGAGGGCGGCGAGAGGAAGCCCGCTACGAGTGCCCTAGCTCCCCGCCGCT
CTCGATGAACCGGACGGAATAAGCCGCGCCTCCAGCAGGGGCTGCGCCTCCATGAATCCCTAGTTGTTTTTTTTTTTTTCTTTCTCTCCC
CTCTCCTCACCCCCACCCCGAGCCCCGTCCCGCCTTCTCCCTTCGCCAGAGGCGGCCGCGTCCAGGTGCGGAGTCCATACCGGAGCGCAA
TGGCGTCCAACCCCGAACGGGGGGAGATTCTGCTCACGGAACTGCAGGGTTTTCCAGGAGATATTGGGATTCCTGGACAAAACGGCCCTG
AAGGACCAAAGGGACTCCTTGGAAATAGAGGACCTCCTGGACCTCCTGGTCTCAAAGGAACTCAGGGAGAAGAAGGACCAATTGGAGCCT
TTGGGGAACTGGGGCCAAGAGGAAAACCAGGTCAAAAGGGGTATGCAGGTGAACCAGGACCAGAAGGCTTAAAGGGAGAAGTAGGAGATC
AAGGAAATATTGGAAAAATTGGTGAAACAGGACCTGTTGGCTTACCTGGAGAAGTTGGGATGACTGGAAGCATTGGCGAAAAGGGAGAAC
GTGGAAGTCCAGGCCCACTAGGTCCGCAGGGAGAAAAAGGTGTTATGGGATATCCAGGTCCTCCTGGGGTTCCAGGACCTATCGGTCCAT
TGGGATTACCTGGTCATGTGGGGGCAAGAGGACCACCTGGGAGTCAAGGTCCTAAAGGACAAAGAGGATCAAGAGGACCAGATGGTCTCT
TAGGGGAACAAGGTATACAAGGTGCCAAGGGTGAAAAAGGAGATCAAGGAAAAAGAGGGCCTCATGGTCTTATTGGTAAGACTGGAAACC
CTGGAGAAAGAGGATTTCAAGGGAAACCAGGTTTACAGGGATTGCCTGGAAGTACAGGTGACAGAGGACTTCCAGGAGAGCCAGGACTGC
GAGGACTGCAAGGTGATGTTGGACCTCCTGGAGAAATGGGCATGGAGGGACCTCCAGGCACTGAGGGAGAGTCTGGTCTGCAAGGTGAAC
CAGGTGCAAAGGGAGATGTTGGAACTGCTGGCAGTGTTGGAGGAACTGGGGAACCAGGTTTACGGGGTGAACCAGGAGCTCCTGGAGAAG
AAGGTCTCCAGGGAAAAGATGGGTTAAAGGGAGTACCAGGAGGAAGGGGACTTCCTGGAGAGGATGGAGAAAAAGGAGAGATGGGCTTAC
CAGGAATTATAGGACCCTTGGGTAGATCAGGCCAAACAGGCCTTCCGGGACCTGAAGGAATTGTGGGAATTCCAGGGCAAAGAGGTCGTC
CAGGAAAAAAGGGTGATAAAGGACAAATAGGACCCACAGGAGAAGTTGGAAGCAGAGGTCCTCCTGGAAAAATTGGGAAAAGTGGTCCTA
AGGGTGCCAGAGGAACTAGAGGTGCTGTGGGACATTTAGGATTGATGGGACCTGATGGAGAACCAGGAATTCCAGGGTACAGGGGCCATC
AGGGCCAACCAGGACCCTCTGGATTGCCAGGACCTAAAGGAGAAAAGGGCTACCCAGGAGAAGATAGCACAGTCCTAGGACCACCTGGGC
CTCGAGGTGAACCAGGTCCAGTGGGGGACCAAGGAGAGAGAGGAGAGCCTGGAGCAGAGGGATATAAGGGCCATGTGGGTGTACCAGGAC
TAAGAGGTGCCACTGGACAACAAGGACCCCCAGGCGAACCAGGTGACCAGGGTGAACAAGGACTAAAAGGAGAGAGAGGATCTGAAGGTA
ATAAGGGGAAAAAAGGAGCTCCTGGTCCTTCTGGGAAACCTGGGATTCCTGGACTTCAAGGCCTACTTGGGCCAAAAGGCATACAAGGAT
ACCATGGAGCAGATGGCATTTCAGGAAACCCTGGAAAAATTGGGCCACCAGGAAAACAGGGACTTCCTGGCATCAGAGGCGGCCCAGGAA
GAACAGGTCTTGCTGGGGCTCCAGGTCCTCCAGGAGTAAAGGGTTCATCAGGCTTGCCAGGAAGCCCAGGAATTCAAGGCCCAAAGGGTG
AACAAGGGCTACCTGGTCAACCTGGAATTCAAGGTAAAAGAGGTCACCGAGGAGCACAAGGTGATCAAGGACCATGTGGAGACCCTGGCC
TGAAAGGGCAGCCTGGAGAATATGGTGTTCAAGGTTTGACAGGTTTCCAAGGATTCCCAGGCCCTAAAGGTCCTGAAGGGGATGCTGGCA
TTGTTGGGATATCAGGTCCTAAAGGTCCTATTGGACACAGAGGAAACACTGGTCCCCTTGGCAGAGAAGGTATAATAGGCCCAACAGGTA
GAACTGGACCCAGAGGTGAAAAGGGCTTTAGAGGTGAAACTAAGCAAATGGATATCAATGCTGCTATTCAAGCCTTGATTGAATCAAATA
CTGCCCTACAGATGGAGAGCTACCAGAATACTGAAGTGACTTTAATTGACCACAGTGAAGAGATATTCAAAACCCTGAACTACCTTAGCA
ATTTATTGCACAGCATCAAGAATCCTCTTGGCACACGAGATAACCCAGCACGAATCTGCAAAGATTTACTTAACTGTGAACAAAAAGTAT
CAGATGGAAAATACTGGATTGACCCAAATCTTGGCTGTCCTTCAGATGCCATTGAGGTTTTCTGCAATTTCAGTGCTGGTGGCCAGACAT
GCTTACCTCCTGTTTCTGTAACAAAGTTGGAGTTTGGAGTTGGGAAAGTCCAGATGAACTTCCTTCATTTACTGAGTTCGGAAGCCACCC
ATATCATCACCATTCACTGTCTAAACACCCCAAGGTGGACAAGCACACAAACAAGTGGCCCAGGATTGCCTATTGGTTTCAAGGGATGGA
ATGGCCAGATTTTTAAAGTAAACACTCTACTTGAACCTAAAGTGCTTTCAGATGACTGCAAGATTCAAGATGGCAGCTGGCATAAGGCAA
CATTTCTTTTTCACACCCAGGAACCTAATCAACTTCCAGTGATTGAAGTACAAAAACTTCCTCATCTCAAAACTGAACGAAAGTATTACA
TTGACAGCAGTTCTGTATGCTTTCTGTAAAGTCTCTGAATTAGTTCCGAATTCAGGCTGTTGGCCAGGTAATTGCTGCAGAGGGAGAAAT
AAGACAGACAGATACAGTCATTATGAAATGCATGTAATAAAGCATTGGCTAAATCTTAAAGAATCTCAGGAAGAACAGACTTCCTCCTAA
GAAGGAGAAAAGGCATTTTTAAAGGACTATGATTGATAAAGTATTTAATTCTTTTAAAAATTATATTCATCTCAGCTTTCTTAGAGAATT
CCCTAGAACTAAAAATTTATAAATATGGAATTCTTCAGGGTATCTTATATTTTTGACTGAGTGCGTAGTACCCATTAGACAGCTGGAGAT
GCAGAGCACTATGGAGCAATACTGGCTAATGCTTCCAGATGTGCACTGCTTCTGTCTAAAAATTACAAGCCACAGTCTAATATGTCTTAT
TTTCCAAAACACTAAGCTGTATTCAGGTCCCCGATGGGCATATACATCTTAGCCGGTGATACACTACCTCTTACGTGTTGCCTCTTTGTG
TTGCTTGGTGCTCTTTCGAAAACAAGGTGCTTATGGCTTTCATAGACTATTTCCTTTTTCATCTTTGTCATTCTTTAAAAGTGTATGTAC
TGGTTACATCAAGATATGTTTTGGTTGTTAGTACTTATTTTAATTTGTTTGGTCACACACTTAATAACACGTGAAACTATTTATGTGAAG
TCCTTGTTTTATTTTAAAATTCTCTTTGTGTATTTGGAATCAAAGCCAGCACATTGTAACCTGTGCTTGTACGCAAAAGAATTAGATTTC
TTTGTTTTTGTTTTATTTTTTAAATTGTTGTAAAAATTATTATAGGCCAGCTACATCTAGTAGTAGGTTTGGGGTACAGATTGGGGGTTG
TGCCATACTGTTTTTAAAGTTCATGATCATCTGGAATGATACTTAGTGTATATATATTTTGTAAAGTTTTAATTCAGCAAATTTTTTGAA
ATTGCTGCTGTTTTAAATTATAAAACCTTTATATTTCTGCTTTGTAGAAATTATATGTTTTGTAGTATTCATTGATTTTCTTTCACTGTA
CTTAAATTTAGTGTTAGTACTTTAAAATTTTTAATTTACCAGTCTTTAAAGCAACATCCAGAAAAAAAAAAGTCTTTTCCCATTTAAAAT
AGGCTCAGCCAGTTCAATGTCTCCTTGTTATCAGAGAAATATTAGTTCAATACTGAAAGAAAAATATTATACCTCTTGGTATCTAGAAAA

>65782_65782_6_PKN2-COL24A1_PKN2_chr1_89150311_ENST00000370521_COL24A1_chr1_86453337_ENST00000436319_length(amino acids)=985AA_BP=62
MRLHESLVVFFFFFLSPLLTPTPSPVPPSPFARGGRVQVRSPYRSAMASNPERGEILLTELQGFPGDIGIPGQNGPEGPKGLLGNRGPPG
PPGLKGTQGEEGPIGAFGELGPRGKPGQKGYAGEPGPEGLKGEVGDQGNIGKIGETGPVGLPGEVGMTGSIGEKGERGSPGPLGPQGEKG
VMGYPGPPGVPGPIGPLGLPGHVGARGPPGSQGPKGQRGSRGPDGLLGEQGIQGAKGEKGDQGKRGPHGLIGKTGNPGERGFQGKPGLQG
LPGSTGDRGLPGEPGLRGLQGDVGPPGEMGMEGPPGTEGESGLQGEPGAKGDVGTAGSVGGTGEPGLRGEPGAPGEEGLQGKDGLKGVPG
GRGLPGEDGEKGEMGLPGIIGPLGRSGQTGLPGPEGIVGIPGQRGRPGKKGDKGQIGPTGEVGSRGPPGKIGKSGPKGARGTRGAVGHLG
LMGPDGEPGIPGYRGHQGQPGPSGLPGPKGEKGYPGEDSTVLGPPGPRGEPGPVGDQGERGEPGAEGYKGHVGVPGLRGATGQQGPPGEP
GDQGEQGLKGERGSEGNKGKKGAPGPSGKPGIPGLQGLLGPKGIQGYHGADGISGNPGKIGPPGKQGLPGIRGGPGRTGLAGAPGPPGVK
GSSGLPGSPGIQGPKGEQGLPGQPGIQGKRGHRGAQGDQGPCGDPGLKGQPGEYGVQGLTGFQGFPGPKGPEGDAGIVGISGPKGPIGHR
GNTGPLGREGIIGPTGRTGPRGEKGFRGETKQMDINAAIQALIESNTALQMESYQNTEVTLIDHSEEIFKTLNYLSNLLHSIKNPLGTRD
NPARICKDLLNCEQKVSDGKYWIDPNLGCPSDAIEVFCNFSAGGQTCLPPVSVTKLEFGVGKVQMNFLHLLSSEATHIITIHCLNTPRWT

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PKN2-COL24A1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PKN2-COL24A1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PKN2-COL24A1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource