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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARL16-LPIN1 (FusionGDB2 ID:6581)

Fusion Gene Summary for ARL16-LPIN1

check button Fusion gene summary
Fusion gene informationFusion gene name: ARL16-LPIN1
Fusion gene ID: 6581
HgeneTgene
Gene symbol

ARL16

LPIN1

Gene ID

339231

23175

Gene nameADP ribosylation factor like GTPase 16lipin 1
Synonyms-PAP1
Cytomap

17q25.3

2p25.1

Type of geneprotein-codingprotein-coding
DescriptionADP-ribosylation factor-like protein 16phosphatidate phosphatase LPIN1
Modification date2020032020200313
UniProtAcc.

Q14693

Ensembl transtripts involved in fusion geneENST00000397498, ENST00000570561, 
ENST00000574938, ENST00000573392, 
ENST00000576135, 		ENST00000256720, 
ENST00000396097, ENST00000396098, 
ENST00000404113, ENST00000464517, 
ENST00000396099, ENST00000425416, 
ENST00000449576, 
Fusion gene scores* DoF score5 X 3 X 4=608 X 7 X 4=224
# samples 58
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/224*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARL16 [Title/Abstract] AND LPIN1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARL16(79650564)-LPIN1(11905658), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ARL16 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LPIN1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ADA403287ARL16chr17

79650564

-LPIN1chr2

11905658

+


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Fusion Gene ORF analysis for ARL16-LPIN1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000397498ENST00000256720ARL16chr17

79650564

-LPIN1chr2

11905658

+
5CDS-intronENST00000397498ENST00000396097ARL16chr17

79650564

-LPIN1chr2

11905658

+
5CDS-intronENST00000397498ENST00000396098ARL16chr17

79650564

-LPIN1chr2

11905658

+
5CDS-intronENST00000397498ENST00000404113ARL16chr17

79650564

-LPIN1chr2

11905658

+
5CDS-intronENST00000397498ENST00000464517ARL16chr17

79650564

-LPIN1chr2

11905658

+
5UTR-3CDSENST00000570561ENST00000396099ARL16chr17

79650564

-LPIN1chr2

11905658

+
5UTR-3CDSENST00000570561ENST00000425416ARL16chr17

79650564

-LPIN1chr2

11905658

+
5UTR-3CDSENST00000570561ENST00000449576ARL16chr17

79650564

-LPIN1chr2

11905658

+
5UTR-3CDSENST00000574938ENST00000396099ARL16chr17

79650564

-LPIN1chr2

11905658

+
5UTR-3CDSENST00000574938ENST00000425416ARL16chr17

79650564

-LPIN1chr2

11905658

+
5UTR-3CDSENST00000574938ENST00000449576ARL16chr17

79650564

-LPIN1chr2

11905658

+
5UTR-5UTRENST00000570561ENST00000256720ARL16chr17

79650564

-LPIN1chr2

11905658

+
5UTR-5UTRENST00000574938ENST00000256720ARL16chr17

79650564

-LPIN1chr2

11905658

+
5UTR-intronENST00000570561ENST00000396097ARL16chr17

79650564

-LPIN1chr2

11905658

+
5UTR-intronENST00000570561ENST00000396098ARL16chr17

79650564

-LPIN1chr2

11905658

+
5UTR-intronENST00000570561ENST00000404113ARL16chr17

79650564

-LPIN1chr2

11905658

+
5UTR-intronENST00000570561ENST00000464517ARL16chr17

79650564

-LPIN1chr2

11905658

+
5UTR-intronENST00000574938ENST00000396097ARL16chr17

79650564

-LPIN1chr2

11905658

+
5UTR-intronENST00000574938ENST00000396098ARL16chr17

79650564

-LPIN1chr2

11905658

+
5UTR-intronENST00000574938ENST00000404113ARL16chr17

79650564

-LPIN1chr2

11905658

+
5UTR-intronENST00000574938ENST00000464517ARL16chr17

79650564

-LPIN1chr2

11905658

+
In-frameENST00000397498ENST00000396099ARL16chr17

79650564

-LPIN1chr2

11905658

+
In-frameENST00000397498ENST00000425416ARL16chr17

79650564

-LPIN1chr2

11905658

+
In-frameENST00000397498ENST00000449576ARL16chr17

79650564

-LPIN1chr2

11905658

+
intron-3CDSENST00000573392ENST00000396099ARL16chr17

79650564

-LPIN1chr2

11905658

+
intron-3CDSENST00000573392ENST00000425416ARL16chr17

79650564

-LPIN1chr2

11905658

+
intron-3CDSENST00000573392ENST00000449576ARL16chr17

79650564

-LPIN1chr2

11905658

+
intron-3CDSENST00000576135ENST00000396099ARL16chr17

79650564

-LPIN1chr2

11905658

+
intron-3CDSENST00000576135ENST00000425416ARL16chr17

79650564

-LPIN1chr2

11905658

+
intron-3CDSENST00000576135ENST00000449576ARL16chr17

79650564

-LPIN1chr2

11905658

+
intron-5UTRENST00000573392ENST00000256720ARL16chr17

79650564

-LPIN1chr2

11905658

+
intron-5UTRENST00000576135ENST00000256720ARL16chr17

79650564

-LPIN1chr2

11905658

+
intron-intronENST00000573392ENST00000396097ARL16chr17

79650564

-LPIN1chr2

11905658

+
intron-intronENST00000573392ENST00000396098ARL16chr17

79650564

-LPIN1chr2

11905658

+
intron-intronENST00000573392ENST00000404113ARL16chr17

79650564

-LPIN1chr2

11905658

+
intron-intronENST00000573392ENST00000464517ARL16chr17

79650564

-LPIN1chr2

11905658

+
intron-intronENST00000576135ENST00000396097ARL16chr17

79650564

-LPIN1chr2

11905658

+
intron-intronENST00000576135ENST00000396098ARL16chr17

79650564

-LPIN1chr2

11905658

+
intron-intronENST00000576135ENST00000404113ARL16chr17

79650564

-LPIN1chr2

11905658

+
intron-intronENST00000576135ENST00000464517ARL16chr17

79650564

-LPIN1chr2

11905658

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000397498ARL16chr1779650564-ENST00000449576LPIN1chr211905658+3177291993080993
ENST00000397498ARL16chr1779650564-ENST00000396099LPIN1chr211905658+3153291993080993
ENST00000397498ARL16chr1779650564-ENST00000425416LPIN1chr211905658+3077291992972957

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000397498ENST00000449576ARL16chr1779650564-LPIN1chr211905658+0.0014760910.9985239
ENST00000397498ENST00000396099ARL16chr1779650564-LPIN1chr211905658+0.0014606630.9985393
ENST00000397498ENST00000425416ARL16chr1779650564-LPIN1chr211905658+0.0016090670.9983909

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Fusion Genomic Features for ARL16-LPIN1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ARL16chr1779650565-LPIN1chr211905658+2.10E-060.99999785
ARL16chr1779650565-LPIN1chr211905658+2.10E-060.99999785

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ARL16-LPIN1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:79650564/chr2:11905658)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.LPIN1

Q14693

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis and therefore controls the metabolism of fatty acids at different levels (PubMed:20231281). Acts also as nuclear transcriptional coactivator for PPARGC1A/PPARA regulatory pathway to modulate lipid metabolism gene expression. Is involved in adipocyte differentiation. Isoform 1 is recruited at the mitochondrion outer membrane and is involved in mitochondrial fission by converting phosphatidic acid to diacylglycerol (By similarity). {ECO:0000250|UniProtKB:Q91ZP3, ECO:0000269|PubMed:20231281}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARL16chr17:79650564chr2:11905658ENST00000397498-2530_3764198.0Nucleotide bindingGTP
TgeneLPIN1chr17:79650564chr2:11905658ENST00000256720020147_1500891.0Compositional biasNote=Poly-Ser
TgeneLPIN1chr17:79650564chr2:11905658ENST00000256720020598_6010891.0Compositional biasNote=Poly-Ser
TgeneLPIN1chr17:79650564chr2:11905658ENST00000425416121147_1503897.0Compositional biasNote=Poly-Ser
TgeneLPIN1chr17:79650564chr2:11905658ENST00000425416121598_6013897.0Compositional biasNote=Poly-Ser
TgeneLPIN1chr17:79650564chr2:11905658ENST00000256720020153_1580891.0MotifNuclear localization signal
TgeneLPIN1chr17:79650564chr2:11905658ENST00000256720020678_6820891.0MotifNote=DXDXT motif
TgeneLPIN1chr17:79650564chr2:11905658ENST00000256720020689_6930891.0MotifNote=LXXIL motif
TgeneLPIN1chr17:79650564chr2:11905658ENST00000425416121153_1583897.0MotifNuclear localization signal
TgeneLPIN1chr17:79650564chr2:11905658ENST00000425416121678_6823897.0MotifNote=DXDXT motif
TgeneLPIN1chr17:79650564chr2:11905658ENST00000425416121689_6933897.0MotifNote=LXXIL motif
TgeneLPIN1chr17:79650564chr2:11905658ENST000002567200201_1080891.0RegionNote=N-LIP
TgeneLPIN1chr17:79650564chr2:11905658ENST00000256720020624_8300891.0RegionNote=C-LIP
TgeneLPIN1chr17:79650564chr2:11905658ENST000004254161211_1083897.0RegionNote=N-LIP
TgeneLPIN1chr17:79650564chr2:11905658ENST00000425416121624_8303897.0RegionNote=C-LIP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARL16chr17:79650564chr2:11905658ENST00000397498-25139_14264198.0Nucleotide bindingGTP
HgeneARL16chr17:79650564chr2:11905658ENST00000397498-2582_8664198.0Nucleotide bindingGTP


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Fusion Gene Sequence for ARL16-LPIN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>6581_6581_1_ARL16-LPIN1_ARL16_chr17_79650564_ENST00000397498_LPIN1_chr2_11905658_ENST00000396099_length(transcript)=3153nt_BP=291nt
GTCTTCCGCTCTCCCGCTAACGCTGCGCGCTAATTGGACGCGCCCTTGGAACAATGAGCCCTAAGAACCAATGAGAAGTCCGAAGGTGAG
AACTATCCAATGAGAGTGGCCGGTGGGCGGGCCTTGAGCCGCGGCGCCGAGCTACGGGTGCCGGGTGGAGCGAAGCACGGAATGTGTCTC
CTGCTGGGGGCCACGGGCGTCGGGAAGACGCTGCTGGTGAAACGGCTGCAGGAGGTGAGCTCCCGGGATGGGAAAGGCGACCTGGGGGAG
CCGCCCCCGACACGGCCCACGGTGCAGACCATGAATTACGTGGGGCAGTTAGCCGGCCAGGTGTTTGTCACCGTGAAGGAGCTCTACAAG
GGGCTGAATCCCGCCACACTCTCAGGGTGCATTGACATCATTGTCATCCGCCAGCCCAATGGAAACCTCCAATGCTCCCCTTTCCACGTC
CGCTTTGGGAAGATGGGGGTCCTGCGCTCCCGAGAGAAAGTGGTTGACATAGAAATCAATGGGGAATCTGTGGATTTGCATATGAAATTG
GGAGATAATGGAGAAGCATTTTTTGTTCAAGAAACAGATAATGATCAGGAAGTTATCCCTATGCACCTGGCCACCTCCCCCATCCTGTCA
GAAGGAGCTTCGAGAATGGAATGCCAGCTGAAAAGGGGCTCTGTGGACAGGATGAGAGGCCTGGACCCCAGCACGCCAGCCCAAGTGATC
GCTCCCAGCGAGACGCCGTCAAGCAGCTCTGTAGTAAAGAAGAGAAGAAAAAGGAGGAGAAAGTCACAGCTGGACAGCCTGAAGAGAGAT
GACAACATGAACACATCTGAGGATGAGGACATGTTCCCCATCGAGATGAGCTCGGATGAGGCCATGGAGCTGCTGGAGAGCAGCAGAACT
CTTCCTAATGATATACCTCCATTCCAAGATGATATTCCTGAGGAAAACCTCTCCCTGGCTGTGATTTACCCTCAGTCAGCCTCATACCCT
AATTCGGATAGAGAGTGGTCACCCACTCCCAGTAGCCTGGTAGATTGCAAAAGGACTGCCCCTCATCTTGCAGTTGCGGCCGAGGGAGGT
CTGTCTAGTTCTTGCCCTCCACAGTCTTCCCTGTTCCATCCTTCGGAAAGTCCTTCCGGTTCCCGACCTTCAACACCTAAAAGTGATTCA
GAATTGGTCAGCAAGTCCACGGAAAGGACAGGGCAGAAGAACCCAGAAATGCTTTGGCTGTGGGGAGAGCTGCCGCAGGCTGCTAAGTCT
TCTTCTCCACACAAGATGAAAGAGTCCAGCCCATTGAGCAGTAGAAAAATTTGTGATAAAAGTCACTTTCAGGCCATTCACAGCGAATCT
TCAGACACTTTTAGTGACCAATCGCCAACTCTGGTCGGTGGGGCACTTTTGGACCAGAACAAGCCTCAGACAGAAATGCAGTTTGTGAAT
GAAGAAGACCTGGAGACCTTAGGAGCAGCAGCGCCACTCTTGCCCATGATCGAGGAGCTCAAACCCCCCTCTGCCAGTGTAGTCCAGACA
GCAAACAAGACGGATTCTCCTTCCAGGAAAAGAGATAAACGAAGCCGACATCTTGGTGCTGACGGCGTCTACTTGGATGACCTCACAGAC
ATGGATCCTGAAGTGGCGGCCCTGTATTTTCCCAAAAACGGAGATCCTTCCGGACTCGCAAAACATGCAAGCGACAACGGAGCCCGGTCA
GCCAACCAGTCCCCGCAGTCGGTGGGCAGCTCGGGCGTGGACAGTGGCGTGGAGAGCACCTCGGACGGGCTGAGGGACCTCCCTTCCATC
GCCATCTCCCTCTGCGGGGGCCTCAGCGACCACCGGGAGATCACGAAAGATGCATTCCTGGAGCAAGCTGTGTCATATCAACAGTTTGTG
GACAACCCCGCTATTATCGATGACCCCAATCTCGTGGTAAAGATTGGGAGTAAATATTATAACTGGACAACAGCAGCACCCCTCCTCCTG
GCAATGCAGGCCTTCCAGAAACCTTTGCCAAAGGCCACTGTGGAATCTATCATGAGGGATAAAATGCCCAAAAAGGGAGGAAGATGGTGG
TTTTCATGGAGGGGAAGAAACACCACAATCAAGGAGGAAAGTAAGCCAGAGCAGTGCTTGGCTGGCAAGGCCCATAGCACCGGAGAGCAA
CCGCCGCAGCTCAGCTTGGCCACCAGGGTAAAGCATGAATCATCCTCCAGTGATGAGGAGCGCGCAGCTGCCAAGCCATCAAACGCAGGC
CACCTCCCTCTTCTGCCTAATGTCAGCTACAAGAAGACTCTCCGGCTGACTTCCGAGCAGCTTAAAAGCTTGAAGTTGAAGAATGGCCCC
AACGACGTGGTTTTCAGTGTCACCACGCAGTACCAAGGCACGTGCCGCTGTGAGGGCACCATCTATCTGTGGAACTGGGATGATAAAGTC
ATCATTTCTGATATTGATGGGACAATTACCAGATCAGATACTCTTGGCCACATTTTGCCCACCCTTGGGAAGGATTGGACCCATCAGGGC
ATCGCTAAGCTGTACCATAAAGTGAGCCAGAATGGATATAAATTTCTCTACTGTTCTGCCCGTGCCATCGGGATGGCGGACATGACGCGG
GGCTACCTGCACTGGGTCAACGAGAGGGGCACGGTGCTGCCCCAGGGGCCCCTGCTGCTGAGTCCCAGCAGCCTCTTCTCTGCCCTGCAC
AGAGAAGTGATTGAAAAGAAGCCAGAAAAGTTTAAAGTCCAGTGTTTGACAGACATCAAAAACCTGTTTTTCCCCAACACAGAACCCTTT
TATGCTGCTTTTGGAAACCGACCAGCTGATGTGTATTCATACAAGCAAGTAGGAGTGTCTTTGAATAGAATATTTACCGTCAACCCTAAA
GGAGAGCTGGTACAGGAACATGCAAAGACCAACATCTCTTCGTATGTGAGACTCTGTGAAGTAGTCGACCACGTTTTCCCGTTGCTGAAA
AGAAGCCATTCTTCAGACTTTCCCTGTTCGGATACCTTCAGTAACTTCACCTTTTGGAGAGAGCCACTGCCACCTTTTGAAAACCAGGAC
ATTCATTCTGCCTCAGCGTAAAATGTCCCAAGCAGCCTCTTGCCAGCAGTGCAGAGCCTGGTTGTCACCCATTAAAGGATAGGTCTCCCC

>6581_6581_1_ARL16-LPIN1_ARL16_chr17_79650564_ENST00000397498_LPIN1_chr2_11905658_ENST00000396099_length(amino acids)=993AA_BP=64
MRVAGGRALSRGAELRVPGGAKHGMCLLLGATGVGKTLLVKRLQEVSSRDGKGDLGEPPPTRPTVQTMNYVGQLAGQVFVTVKELYKGLN
PATLSGCIDIIVIRQPNGNLQCSPFHVRFGKMGVLRSREKVVDIEINGESVDLHMKLGDNGEAFFVQETDNDQEVIPMHLATSPILSEGA
SRMECQLKRGSVDRMRGLDPSTPAQVIAPSETPSSSSVVKKRRKRRRKSQLDSLKRDDNMNTSEDEDMFPIEMSSDEAMELLESSRTLPN
DIPPFQDDIPEENLSLAVIYPQSASYPNSDREWSPTPSSLVDCKRTAPHLAVAAEGGLSSSCPPQSSLFHPSESPSGSRPSTPKSDSELV
SKSTERTGQKNPEMLWLWGELPQAAKSSSPHKMKESSPLSSRKICDKSHFQAIHSESSDTFSDQSPTLVGGALLDQNKPQTEMQFVNEED
LETLGAAAPLLPMIEELKPPSASVVQTANKTDSPSRKRDKRSRHLGADGVYLDDLTDMDPEVAALYFPKNGDPSGLAKHASDNGARSANQ
SPQSVGSSGVDSGVESTSDGLRDLPSIAISLCGGLSDHREITKDAFLEQAVSYQQFVDNPAIIDDPNLVVKIGSKYYNWTTAAPLLLAMQ
AFQKPLPKATVESIMRDKMPKKGGRWWFSWRGRNTTIKEESKPEQCLAGKAHSTGEQPPQLSLATRVKHESSSSDEERAAAKPSNAGHLP
LLPNVSYKKTLRLTSEQLKSLKLKNGPNDVVFSVTTQYQGTCRCEGTIYLWNWDDKVIISDIDGTITRSDTLGHILPTLGKDWTHQGIAK
LYHKVSQNGYKFLYCSARAIGMADMTRGYLHWVNERGTVLPQGPLLLSPSSLFSALHREVIEKKPEKFKVQCLTDIKNLFFPNTEPFYAA
FGNRPADVYSYKQVGVSLNRIFTVNPKGELVQEHAKTNISSYVRLCEVVDHVFPLLKRSHSSDFPCSDTFSNFTFWREPLPPFENQDIHS

--------------------------------------------------------------
>6581_6581_2_ARL16-LPIN1_ARL16_chr17_79650564_ENST00000397498_LPIN1_chr2_11905658_ENST00000425416_length(transcript)=3077nt_BP=291nt
GTCTTCCGCTCTCCCGCTAACGCTGCGCGCTAATTGGACGCGCCCTTGGAACAATGAGCCCTAAGAACCAATGAGAAGTCCGAAGGTGAG
AACTATCCAATGAGAGTGGCCGGTGGGCGGGCCTTGAGCCGCGGCGCCGAGCTACGGGTGCCGGGTGGAGCGAAGCACGGAATGTGTCTC
CTGCTGGGGGCCACGGGCGTCGGGAAGACGCTGCTGGTGAAACGGCTGCAGGAGGTGAGCTCCCGGGATGGGAAAGGCGACCTGGGGGAG
CCGCCCCCGACACGGCCCACGGTGCAGACCATGAATTACGTGGGGCAGTTAGCCGGCCAGGTGTTTGTCACCGTGAAGGAGCTCTACAAG
GGGCTGAATCCCGCCACACTCTCAGGGTGCATTGACATCATTGTCATCCGCCAGCCCAATGGAAACCTCCAATGCTCCCCTTTCCACGTC
CGCTTTGGGAAGATGGGGGTCCTGCGCTCCCGAGAGAAAGTGGTTGACATAGAAATCAATGGGGAATCTGTGGATTTGCATATGAAATTG
GGAGATAATGGAGAAGCATTTTTTGTTCAAGAAACAGATAATGATCAGGAAGTTATCCCTATGCACCTGGCCACCTCCCCCATCCTGTCA
GAAGGAGCTTCGAGAATGGAATGCCAGCTGAAAAGGGGCTCTGTGGACAGGATGAGAGGCCTGGACCCCAGCACGCCAGCCCAAGTGATC
GCTCCCAGCGAGACGCCGTCAAGCAGCTCTGTAGTAAAGAAGAGAAGAAAAAGGAGGAGAAAGTCACAGCTGGACAGCCTGAAGAGAGAT
GACAACATGAACACATCTGAGGATGAGGACATGTTCCCCATCGAGATGAGCTCGGATGAGGCCATGGAGCTGCTGGAGAGCAGCAGAACT
CTTCCTAATGATATACCTCCATTCCAAGATGATATTCCTGAGGAAAACCTCTCCCTGGCTGTGATTTACCCTCAGTCAGCCTCATACCCT
AATTCGGATAGAGAGTGGTCACCCACTCCCAGTCCTTCCGGTTCCCGACCTTCAACACCTAAAAGTGATTCAGAATTGGTCAGCAAGTCC
ACGGAAAGGACAGGGCAGAAGAACCCAGAAATGCTTTGGCTGTGGGGAGAGCTGCCGCAGGCTGCTAAGTCTTCTTCTCCACACAAGATG
AAAGAGTCCAGCCCATTGAGCAGTAGAAAAATTTGTGATAAAAGTCACTTTCAGGCCATTCACAGCGAATCTTCAGACACTTTTAGTGAC
CAATCGCCAACTCTGGTCGGTGGGGCACTTTTGGACCAGAACAAGCCTCAGACAGAAATGCAGTTTGTGAATGAAGAAGACCTGGAGACC
TTAGGAGCAGCAGCGCCACTCTTGCCCATGATCGAGGAGCTCAAACCCCCCTCTGCCAGTGTAGTCCAGACAGCAAACAAGACGGATTCT
CCTTCCAGGAAAAGAGATAAACGAAGCCGACATCTTGGTGCTGACGGCGTCTACTTGGATGACCTCACAGACATGGATCCTGAAGTGGCG
GCCCTGTATTTTCCCAAAAACGGAGATCCTTCCGGACTCGCAAAACATGCAAGCGACAACGGAGCCCGGTCAGCCAACCAGTCCCCGCAG
TCGGTGGGCAGCTCGGGCGTGGACAGTGGCGTGGAGAGCACCTCGGACGGGCTGAGGGACCTCCCTTCCATCGCCATCTCCCTCTGCGGG
GGCCTCAGCGACCACCGGGAGATCACGAAAGATGCATTCCTGGAGCAAGCTGTGTCATATCAACAGTTTGTGGACAACCCCGCTATTATC
GATGACCCCAATCTCGTGGTAAAGATTGGGAGTAAATATTATAACTGGACAACAGCAGCACCCCTCCTCCTGGCAATGCAGGCCTTCCAG
AAACCTTTGCCAAAGGCCACTGTGGAATCTATCATGAGGGATAAAATGCCCAAAAAGGGAGGAAGATGGTGGTTTTCATGGAGGGGAAGA
AACACCACAATCAAGGAGGAAAGTAAGCCAGAGCAGTGCTTGGCTGGCAAGGCCCATAGCACCGGAGAGCAACCGCCGCAGCTCAGCTTG
GCCACCAGGGTAAAGCATGAATCATCCTCCAGTGATGAGGAGCGCGCAGCTGCCAAGCCATCAAACGCAGGCCACCTCCCTCTTCTGCCT
AATGTCAGCTACAAGAAGACTCTCCGGCTGACTTCCGAGCAGCTTAAAAGCTTGAAGTTGAAGAATGGCCCCAACGACGTGGTTTTCAGT
GTCACCACGCAGTACCAAGGCACGTGCCGCTGTGAGGGCACCATCTATCTGTGGAACTGGGATGATAAAGTCATCATTTCTGATATTGAT
GGGACAATTACCAGATCAGATACTCTTGGCCACATTTTGCCCACCCTTGGGAAGGATTGGACCCATCAGGGCATCGCTAAGCTGTACCAT
AAAGTGAGCCAGAATGGATATAAATTTCTCTACTGTTCTGCCCGTGCCATCGGGATGGCGGACATGACGCGGGGCTACCTGCACTGGGTC
AACGAGAGGGGCACGGTGCTGCCCCAGGGGCCCCTGCTGCTGAGTCCCAGCAGCCTCTTCTCTGCCCTGCACAGAGAAGTGATTGAAAAG
AAGCCAGAAAAGTTTAAAGTCCAGTGTTTGACAGACATCAAAAACCTGTTTTTCCCCAACACAGAACCCTTTTATGCTGCTTTTGGAAAC
CGACCAGCTGATGTGTATTCATACAAGCAAGTAGGAGTGTCTTTGAATAGAATATTTACCGTCAACCCTAAAGGAGAGCTGGTACAGGAA
CATGCAAAGACCAACATCTCTTCGTATGTGAGACTCTGTGAAGTAGTCGACCACGTTTTCCCGTTGCTGAAAAGAAGCCATTCTTCAGAC
TTTCCCTGTTCGGATACCTTCAGTAACTTCACCTTTTGGAGAGAGCCACTGCCACCTTTTGAAAACCAGGACATTCATTCTGCCTCAGCG
TAAAATGTCCCAAGCAGCCTCTTGCCAGCAGTGCAGAGCCTGGTTGTCACCCATTAAAGGATAGGTCTCCCCGGAGTGCACAGCTCCACC

>6581_6581_2_ARL16-LPIN1_ARL16_chr17_79650564_ENST00000397498_LPIN1_chr2_11905658_ENST00000425416_length(amino acids)=957AA_BP=64
MRVAGGRALSRGAELRVPGGAKHGMCLLLGATGVGKTLLVKRLQEVSSRDGKGDLGEPPPTRPTVQTMNYVGQLAGQVFVTVKELYKGLN
PATLSGCIDIIVIRQPNGNLQCSPFHVRFGKMGVLRSREKVVDIEINGESVDLHMKLGDNGEAFFVQETDNDQEVIPMHLATSPILSEGA
SRMECQLKRGSVDRMRGLDPSTPAQVIAPSETPSSSSVVKKRRKRRRKSQLDSLKRDDNMNTSEDEDMFPIEMSSDEAMELLESSRTLPN
DIPPFQDDIPEENLSLAVIYPQSASYPNSDREWSPTPSPSGSRPSTPKSDSELVSKSTERTGQKNPEMLWLWGELPQAAKSSSPHKMKES
SPLSSRKICDKSHFQAIHSESSDTFSDQSPTLVGGALLDQNKPQTEMQFVNEEDLETLGAAAPLLPMIEELKPPSASVVQTANKTDSPSR
KRDKRSRHLGADGVYLDDLTDMDPEVAALYFPKNGDPSGLAKHASDNGARSANQSPQSVGSSGVDSGVESTSDGLRDLPSIAISLCGGLS
DHREITKDAFLEQAVSYQQFVDNPAIIDDPNLVVKIGSKYYNWTTAAPLLLAMQAFQKPLPKATVESIMRDKMPKKGGRWWFSWRGRNTT
IKEESKPEQCLAGKAHSTGEQPPQLSLATRVKHESSSSDEERAAAKPSNAGHLPLLPNVSYKKTLRLTSEQLKSLKLKNGPNDVVFSVTT
QYQGTCRCEGTIYLWNWDDKVIISDIDGTITRSDTLGHILPTLGKDWTHQGIAKLYHKVSQNGYKFLYCSARAIGMADMTRGYLHWVNER
GTVLPQGPLLLSPSSLFSALHREVIEKKPEKFKVQCLTDIKNLFFPNTEPFYAAFGNRPADVYSYKQVGVSLNRIFTVNPKGELVQEHAK

--------------------------------------------------------------
>6581_6581_3_ARL16-LPIN1_ARL16_chr17_79650564_ENST00000397498_LPIN1_chr2_11905658_ENST00000449576_length(transcript)=3177nt_BP=291nt
GTCTTCCGCTCTCCCGCTAACGCTGCGCGCTAATTGGACGCGCCCTTGGAACAATGAGCCCTAAGAACCAATGAGAAGTCCGAAGGTGAG
AACTATCCAATGAGAGTGGCCGGTGGGCGGGCCTTGAGCCGCGGCGCCGAGCTACGGGTGCCGGGTGGAGCGAAGCACGGAATGTGTCTC
CTGCTGGGGGCCACGGGCGTCGGGAAGACGCTGCTGGTGAAACGGCTGCAGGAGGTGAGCTCCCGGGATGGGAAAGGCGACCTGGGGGAG
CCGCCCCCGACACGGCCCACGGTGCAGACCATGAATTACGTGGGGCAGTTAGCCGGCCAGGTGTTTGTCACCGTGAAGGAGCTCTACAAG
GGGCTGAATCCCGCCACACTCTCAGGGTGCATTGACATCATTGTCATCCGCCAGCCCAATGGAAACCTCCAATGCTCCCCTTTCCACGTC
CGCTTTGGGAAGATGGGGGTCCTGCGCTCCCGAGAGAAAGTGGTTGACATAGAAATCAATGGGGAATCTGTGGATTTGCATATGAAATTG
GGAGATAATGGAGAAGCATTTTTTGTTCAAGAAACAGATAATGATCAGGAAGTTATCCCTATGCACCTGGCCACCTCCCCCATCCTGTCA
GAAGGAGCTTCGAGAATGGAATGCCAGCTGAAAAGGGGCTCTGTGGACAGGATGAGAGGCCTGGACCCCAGCACGCCAGCCCAAGTGATC
GCTCCCAGCGAGACGCCGTCAAGCAGCTCTGTAGTAAAGAAGAGAAGAAAAAGGAGGAGAAAGTCACAGCTGGACAGCCTGAAGAGAGAT
GACAACATGAACACATCTGAGGATGAGGACATGTTCCCCATCGAGATGAGCTCGGATGAGGCCATGGAGCTGCTGGAGAGCAGCAGAACT
CTTCCTAATGATATACCTCCATTCCAAGATGATATTCCTGAGGAAAACCTCTCCCTGGCTGTGATTTACCCTCAGTCAGCCTCATACCCT
AATTCGGATAGAGAGTGGTCACCCACTCCCAGTAGCCTGGTAGATTGCAAAAGGACTGCCCCTCATCTTGCAGTTGCGGCCGAGGGAGGT
CTGTCTAGTTCTTGCCCTCCACAGTCTTCCCTGTTCCATCCTTCGGAAAGTCCTTCCGGTTCCCGACCTTCAACACCTAAAAGTGATTCA
GAATTGGTCAGCAAGTCCACGGAAAGGACAGGGCAGAAGAACCCAGAAATGCTTTGGCTGTGGGGAGAGCTGCCGCAGGCTGCTAAGTCT
TCTTCTCCACACAAGATGAAAGAGTCCAGCCCATTGAGCAGTAGAAAAATTTGTGATAAAAGTCACTTTCAGGCCATTCACAGCGAATCT
TCAGACACTTTTAGTGACCAATCGCCAACTCTGGTCGGTGGGGCACTTTTGGACCAGAACAAGCCTCAGACAGAAATGCAGTTTGTGAAT
GAAGAAGACCTGGAGACCTTAGGAGCAGCAGCGCCACTCTTGCCCATGATCGAGGAGCTCAAACCCCCCTCTGCCAGTGTAGTCCAGACA
GCAAACAAGACGGATTCTCCTTCCAGGAAAAGAGATAAACGAAGCCGACATCTTGGTGCTGACGGCGTCTACTTGGATGACCTCACAGAC
ATGGATCCTGAAGTGGCGGCCCTGTATTTTCCCAAAAACGGAGATCCTTCCGGACTCGCAAAACATGCAAGCGACAACGGAGCCCGGTCA
GCCAACCAGTCCCCGCAGTCGGTGGGCAGCTCGGGCGTGGACAGTGGCGTGGAGAGCACCTCGGACGGGCTGAGGGACCTCCCTTCCATC
GCCATCTCCCTCTGCGGGGGCCTCAGCGACCACCGGGAGATCACGAAAGATGCATTCCTGGAGCAAGCTGTGTCATATCAACAGTTTGTG
GACAACCCCGCTATTATCGATGACCCCAATCTCGTGGTAAAGATTGGGAGTAAATATTATAACTGGACAACAGCAGCACCCCTCCTCCTG
GCAATGCAGGCCTTCCAGAAACCTTTGCCAAAGGCCACTGTGGAATCTATCATGAGGGATAAAATGCCCAAAAAGGGAGGAAGATGGTGG
TTTTCATGGAGGGGAAGAAACACCACAATCAAGGAGGAAAGTAAGCCAGAGCAGTGCTTGGCTGGCAAGGCCCATAGCACCGGAGAGCAA
CCGCCGCAGCTCAGCTTGGCCACCAGGGTAAAGCATGAATCATCCTCCAGTGATGAGGAGCGCGCAGCTGCCAAGCCATCAAACGCAGGC
CACCTCCCTCTTCTGCCTAATGTCAGCTACAAGAAGACTCTCCGGCTGACTTCCGAGCAGCTTAAAAGCTTGAAGTTGAAGAATGGCCCC
AACGACGTGGTTTTCAGTGTCACCACGCAGTACCAAGGCACGTGCCGCTGTGAGGGCACCATCTATCTGTGGAACTGGGATGATAAAGTC
ATCATTTCTGATATTGATGGGACAATTACCAGATCAGATACTCTTGGCCACATTTTGCCCACCCTTGGGAAGGATTGGACCCATCAGGGC
ATCGCTAAGCTGTACCATAAAGTGAGCCAGAATGGATATAAATTTCTCTACTGTTCTGCCCGTGCCATCGGGATGGCGGACATGACGCGG
GGCTACCTGCACTGGGTCAACGAGAGGGGCACGGTGCTGCCCCAGGGGCCCCTGCTGCTGAGTCCCAGCAGCCTCTTCTCTGCCCTGCAC
AGAGAAGTGATTGAAAAGAAGCCAGAAAAGTTTAAAGTCCAGTGTTTGACAGACATCAAAAACCTGTTTTTCCCCAACACAGAACCCTTT
TATGCTGCTTTTGGAAACCGACCAGCTGATGTGTATTCATACAAGCAAGTAGGAGTGTCTTTGAATAGAATATTTACCGTCAACCCTAAA
GGAGAGCTGGTACAGGAACATGCAAAGACCAACATCTCTTCGTATGTGAGACTCTGTGAAGTAGTCGACCACGTTTTCCCGTTGCTGAAA
AGAAGCCATTCTTCAGACTTTCCCTGTTCGGATACCTTCAGTAACTTCACCTTTTGGAGAGAGCCACTGCCACCTTTTGAAAACCAGGAC
ATTCATTCTGCCTCAGCGTAAAATGTCCCAAGCAGCCTCTTGCCAGCAGTGCAGAGCCTGGTTGTCACCCATTAAAGGATAGGTCTCCCC

>6581_6581_3_ARL16-LPIN1_ARL16_chr17_79650564_ENST00000397498_LPIN1_chr2_11905658_ENST00000449576_length(amino acids)=993AA_BP=64
MRVAGGRALSRGAELRVPGGAKHGMCLLLGATGVGKTLLVKRLQEVSSRDGKGDLGEPPPTRPTVQTMNYVGQLAGQVFVTVKELYKGLN
PATLSGCIDIIVIRQPNGNLQCSPFHVRFGKMGVLRSREKVVDIEINGESVDLHMKLGDNGEAFFVQETDNDQEVIPMHLATSPILSEGA
SRMECQLKRGSVDRMRGLDPSTPAQVIAPSETPSSSSVVKKRRKRRRKSQLDSLKRDDNMNTSEDEDMFPIEMSSDEAMELLESSRTLPN
DIPPFQDDIPEENLSLAVIYPQSASYPNSDREWSPTPSSLVDCKRTAPHLAVAAEGGLSSSCPPQSSLFHPSESPSGSRPSTPKSDSELV
SKSTERTGQKNPEMLWLWGELPQAAKSSSPHKMKESSPLSSRKICDKSHFQAIHSESSDTFSDQSPTLVGGALLDQNKPQTEMQFVNEED
LETLGAAAPLLPMIEELKPPSASVVQTANKTDSPSRKRDKRSRHLGADGVYLDDLTDMDPEVAALYFPKNGDPSGLAKHASDNGARSANQ
SPQSVGSSGVDSGVESTSDGLRDLPSIAISLCGGLSDHREITKDAFLEQAVSYQQFVDNPAIIDDPNLVVKIGSKYYNWTTAAPLLLAMQ
AFQKPLPKATVESIMRDKMPKKGGRWWFSWRGRNTTIKEESKPEQCLAGKAHSTGEQPPQLSLATRVKHESSSSDEERAAAKPSNAGHLP
LLPNVSYKKTLRLTSEQLKSLKLKNGPNDVVFSVTTQYQGTCRCEGTIYLWNWDDKVIISDIDGTITRSDTLGHILPTLGKDWTHQGIAK
LYHKVSQNGYKFLYCSARAIGMADMTRGYLHWVNERGTVLPQGPLLLSPSSLFSALHREVIEKKPEKFKVQCLTDIKNLFFPNTEPFYAA
FGNRPADVYSYKQVGVSLNRIFTVNPKGELVQEHAKTNISSYVRLCEVVDHVFPLLKRSHSSDFPCSDTFSNFTFWREPLPPFENQDIHS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ARL16-LPIN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARL16-LPIN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARL16-LPIN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource