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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PLA2G6-TMEM184B (FusionGDB2 ID:65880)

Fusion Gene Summary for PLA2G6-TMEM184B

check button Fusion gene summary
Fusion gene informationFusion gene name: PLA2G6-TMEM184B
Fusion gene ID: 65880
HgeneTgene
Gene symbol

PLA2G6

TMEM184B

Gene ID

8398

25829

Gene namephospholipase A2 group VItransmembrane protein 184B
SynonymsCaI-PLA2|GVI|INAD1|IPLA2-VIA|NBIA2|NBIA2A|NBIA2B|PARK14|PLA2|PNPLA9|iPLA2|iPLA2betaC22orf5|FM08|HS5O6A|HSPC256
Cytomap

22q13.1

22q13.1

Type of geneprotein-codingprotein-coding
Description85/88 kDa calcium-independent phospholipase A285 kDa calcium-independent phospholipase A2GVI PLA2iPLA2-betaintracellular membrane-associated calcium-independent phospholipase A2 betaneurodegeneration with brain iron accumulation 2patatin-like phosphtransmembrane protein 184Bputative MAPK-activating protein FM08
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000332509, ENST00000335539, 
ENST00000402064, ENST00000417303, 
ENST00000435484, ENST00000436218, 
ENST00000447598, ENST00000490473, 
ENST00000504337, ENST00000361684, 
ENST00000361906, 
Fusion gene scores* DoF score9 X 12 X 6=64812 X 9 X 8=864
# samples 1316
** MAII scorelog2(13/648*10)=-2.31748218985617
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/864*10)=-2.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PLA2G6 [Title/Abstract] AND TMEM184B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPLA2G6(38577791)-TMEM184B(38627340), # samples:3
Anticipated loss of major functional domain due to fusion event.PLA2G6-TMEM184B seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
PLA2G6-TMEM184B seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePLA2G6

GO:0019731

antibacterial humoral response

18714013


check buttonFusion gene breakpoints across PLA2G6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TMEM184B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E2-A1L7-01APLA2G6chr22

38565225

-TMEM184Bchr22

38622877

-
ChimerDB4SKCMTCGA-FS-A4F4-06APLA2G6chr22

38577791

-TMEM184Bchr22

38627340

-
ChimerDB4SKCMTCGA-FS-A4F4PLA2G6chr22

38577790

-TMEM184Bchr22

38627340

-


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Fusion Gene ORF analysis for PLA2G6-TMEM184B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000332509ENST00000504337PLA2G6chr22

38565225

-TMEM184Bchr22

38622877

-
5CDS-intronENST00000335539ENST00000504337PLA2G6chr22

38565225

-TMEM184Bchr22

38622877

-
5CDS-intronENST00000402064ENST00000504337PLA2G6chr22

38565225

-TMEM184Bchr22

38622877

-
5CDS-intronENST00000417303ENST00000504337PLA2G6chr22

38565225

-TMEM184Bchr22

38622877

-
5CDS-intronENST00000435484ENST00000504337PLA2G6chr22

38565225

-TMEM184Bchr22

38622877

-
5CDS-intronENST00000436218ENST00000504337PLA2G6chr22

38565225

-TMEM184Bchr22

38622877

-
5CDS-intronENST00000447598ENST00000504337PLA2G6chr22

38565225

-TMEM184Bchr22

38622877

-
5UTR-3CDSENST00000402064ENST00000361684PLA2G6chr22

38577791

-TMEM184Bchr22

38627340

-
5UTR-3CDSENST00000402064ENST00000361684PLA2G6chr22

38577790

-TMEM184Bchr22

38627340

-
5UTR-3CDSENST00000402064ENST00000361906PLA2G6chr22

38577791

-TMEM184Bchr22

38627340

-
5UTR-3CDSENST00000402064ENST00000361906PLA2G6chr22

38577790

-TMEM184Bchr22

38627340

-
5UTR-3CDSENST00000436218ENST00000361684PLA2G6chr22

38577791

-TMEM184Bchr22

38627340

-
5UTR-3CDSENST00000436218ENST00000361684PLA2G6chr22

38577790

-TMEM184Bchr22

38627340

-
5UTR-3CDSENST00000436218ENST00000361906PLA2G6chr22

38577791

-TMEM184Bchr22

38627340

-
5UTR-3CDSENST00000436218ENST00000361906PLA2G6chr22

38577790

-TMEM184Bchr22

38627340

-
5UTR-3CDSENST00000447598ENST00000361684PLA2G6chr22

38577791

-TMEM184Bchr22

38627340

-
5UTR-3CDSENST00000447598ENST00000361684PLA2G6chr22

38577790

-TMEM184Bchr22

38627340

-
5UTR-3CDSENST00000447598ENST00000361906PLA2G6chr22

38577791

-TMEM184Bchr22

38627340

-
5UTR-3CDSENST00000447598ENST00000361906PLA2G6chr22

38577790

-TMEM184Bchr22

38627340

-
5UTR-intronENST00000402064ENST00000504337PLA2G6chr22

38577791

-TMEM184Bchr22

38627340

-
5UTR-intronENST00000402064ENST00000504337PLA2G6chr22

38577790

-TMEM184Bchr22

38627340

-
5UTR-intronENST00000436218ENST00000504337PLA2G6chr22

38577791

-TMEM184Bchr22

38627340

-
5UTR-intronENST00000436218ENST00000504337PLA2G6chr22

38577790

-TMEM184Bchr22

38627340

-
5UTR-intronENST00000447598ENST00000504337PLA2G6chr22

38577791

-TMEM184Bchr22

38627340

-
5UTR-intronENST00000447598ENST00000504337PLA2G6chr22

38577790

-TMEM184Bchr22

38627340

-
Frame-shiftENST00000332509ENST00000361684PLA2G6chr22

38565225

-TMEM184Bchr22

38622877

-
Frame-shiftENST00000332509ENST00000361906PLA2G6chr22

38565225

-TMEM184Bchr22

38622877

-
Frame-shiftENST00000335539ENST00000361684PLA2G6chr22

38565225

-TMEM184Bchr22

38622877

-
Frame-shiftENST00000335539ENST00000361906PLA2G6chr22

38565225

-TMEM184Bchr22

38622877

-
Frame-shiftENST00000402064ENST00000361684PLA2G6chr22

38565225

-TMEM184Bchr22

38622877

-
Frame-shiftENST00000402064ENST00000361906PLA2G6chr22

38565225

-TMEM184Bchr22

38622877

-
Frame-shiftENST00000436218ENST00000361684PLA2G6chr22

38565225

-TMEM184Bchr22

38622877

-
Frame-shiftENST00000436218ENST00000361906PLA2G6chr22

38565225

-TMEM184Bchr22

38622877

-
In-frameENST00000417303ENST00000361684PLA2G6chr22

38565225

-TMEM184Bchr22

38622877

-
In-frameENST00000417303ENST00000361906PLA2G6chr22

38565225

-TMEM184Bchr22

38622877

-
In-frameENST00000435484ENST00000361684PLA2G6chr22

38565225

-TMEM184Bchr22

38622877

-
In-frameENST00000435484ENST00000361906PLA2G6chr22

38565225

-TMEM184Bchr22

38622877

-
In-frameENST00000447598ENST00000361684PLA2G6chr22

38565225

-TMEM184Bchr22

38622877

-
In-frameENST00000447598ENST00000361906PLA2G6chr22

38565225

-TMEM184Bchr22

38622877

-
intron-3CDSENST00000332509ENST00000361684PLA2G6chr22

38577791

-TMEM184Bchr22

38627340

-
intron-3CDSENST00000332509ENST00000361684PLA2G6chr22

38577790

-TMEM184Bchr22

38627340

-
intron-3CDSENST00000332509ENST00000361906PLA2G6chr22

38577791

-TMEM184Bchr22

38627340

-
intron-3CDSENST00000332509ENST00000361906PLA2G6chr22

38577790

-TMEM184Bchr22

38627340

-
intron-3CDSENST00000335539ENST00000361684PLA2G6chr22

38577791

-TMEM184Bchr22

38627340

-
intron-3CDSENST00000335539ENST00000361684PLA2G6chr22

38577790

-TMEM184Bchr22

38627340

-
intron-3CDSENST00000335539ENST00000361906PLA2G6chr22

38577791

-TMEM184Bchr22

38627340

-
intron-3CDSENST00000335539ENST00000361906PLA2G6chr22

38577790

-TMEM184Bchr22

38627340

-
intron-3CDSENST00000417303ENST00000361684PLA2G6chr22

38577791

-TMEM184Bchr22

38627340

-
intron-3CDSENST00000417303ENST00000361684PLA2G6chr22

38577790

-TMEM184Bchr22

38627340

-
intron-3CDSENST00000417303ENST00000361906PLA2G6chr22

38577791

-TMEM184Bchr22

38627340

-
intron-3CDSENST00000417303ENST00000361906PLA2G6chr22

38577790

-TMEM184Bchr22

38627340

-
intron-3CDSENST00000435484ENST00000361684PLA2G6chr22

38577791

-TMEM184Bchr22

38627340

-
intron-3CDSENST00000435484ENST00000361684PLA2G6chr22

38577790

-TMEM184Bchr22

38627340

-
intron-3CDSENST00000435484ENST00000361906PLA2G6chr22

38577791

-TMEM184Bchr22

38627340

-
intron-3CDSENST00000435484ENST00000361906PLA2G6chr22

38577790

-TMEM184Bchr22

38627340

-
intron-3CDSENST00000490473ENST00000361684PLA2G6chr22

38565225

-TMEM184Bchr22

38622877

-
intron-3CDSENST00000490473ENST00000361684PLA2G6chr22

38577791

-TMEM184Bchr22

38627340

-
intron-3CDSENST00000490473ENST00000361684PLA2G6chr22

38577790

-TMEM184Bchr22

38627340

-
intron-3CDSENST00000490473ENST00000361906PLA2G6chr22

38565225

-TMEM184Bchr22

38622877

-
intron-3CDSENST00000490473ENST00000361906PLA2G6chr22

38577791

-TMEM184Bchr22

38627340

-
intron-3CDSENST00000490473ENST00000361906PLA2G6chr22

38577790

-TMEM184Bchr22

38627340

-
intron-intronENST00000332509ENST00000504337PLA2G6chr22

38577791

-TMEM184Bchr22

38627340

-
intron-intronENST00000332509ENST00000504337PLA2G6chr22

38577790

-TMEM184Bchr22

38627340

-
intron-intronENST00000335539ENST00000504337PLA2G6chr22

38577791

-TMEM184Bchr22

38627340

-
intron-intronENST00000335539ENST00000504337PLA2G6chr22

38577790

-TMEM184Bchr22

38627340

-
intron-intronENST00000417303ENST00000504337PLA2G6chr22

38577791

-TMEM184Bchr22

38627340

-
intron-intronENST00000417303ENST00000504337PLA2G6chr22

38577790

-TMEM184Bchr22

38627340

-
intron-intronENST00000435484ENST00000504337PLA2G6chr22

38577791

-TMEM184Bchr22

38627340

-
intron-intronENST00000435484ENST00000504337PLA2G6chr22

38577790

-TMEM184Bchr22

38627340

-
intron-intronENST00000490473ENST00000504337PLA2G6chr22

38565225

-TMEM184Bchr22

38622877

-
intron-intronENST00000490473ENST00000504337PLA2G6chr22

38577791

-TMEM184Bchr22

38627340

-
intron-intronENST00000490473ENST00000504337PLA2G6chr22

38577790

-TMEM184Bchr22

38627340

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for PLA2G6-TMEM184B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PLA2G6-TMEM184B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:38577791/chr22:38627340)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTMEM184Bchr22:38565225chr22:38622877ENST0000036168449178_198175408.0TransmembraneHelical
TgeneTMEM184Bchr22:38565225chr22:38622877ENST0000036168449214_234175408.0TransmembraneHelical
TgeneTMEM184Bchr22:38565225chr22:38622877ENST0000036168449249_269175408.0TransmembraneHelical
TgeneTMEM184Bchr22:38565225chr22:38622877ENST0000036168449290_310175408.0TransmembraneHelical
TgeneTMEM184Bchr22:38565225chr22:38622877ENST0000036190649178_198175408.0TransmembraneHelical
TgeneTMEM184Bchr22:38565225chr22:38622877ENST0000036190649214_234175408.0TransmembraneHelical
TgeneTMEM184Bchr22:38565225chr22:38622877ENST0000036190649249_269175408.0TransmembraneHelical
TgeneTMEM184Bchr22:38565225chr22:38622877ENST0000036190649290_310175408.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePLA2G6chr22:38565225chr22:38622877ENST00000332509-217481_66569807.0DomainPNPLA
HgenePLA2G6chr22:38565225chr22:38622877ENST00000335539-216481_66569753.0DomainPNPLA
HgenePLA2G6chr22:38565225chr22:38622877ENST00000402064-216481_66569753.0DomainPNPLA
HgenePLA2G6chr22:38565225chr22:38622877ENST00000332509-217485_49069807.0MotifGXGXXG
HgenePLA2G6chr22:38565225chr22:38622877ENST00000332509-217517_52169807.0MotifGXSXG
HgenePLA2G6chr22:38565225chr22:38622877ENST00000332509-217652_65469807.0MotifDGA/G
HgenePLA2G6chr22:38565225chr22:38622877ENST00000335539-216485_49069753.0MotifGXGXXG
HgenePLA2G6chr22:38565225chr22:38622877ENST00000335539-216517_52169753.0MotifGXSXG
HgenePLA2G6chr22:38565225chr22:38622877ENST00000335539-216652_65469753.0MotifDGA/G
HgenePLA2G6chr22:38565225chr22:38622877ENST00000402064-216485_49069753.0MotifGXGXXG
HgenePLA2G6chr22:38565225chr22:38622877ENST00000402064-216517_52169753.0MotifGXSXG
HgenePLA2G6chr22:38565225chr22:38622877ENST00000402064-216652_65469753.0MotifDGA/G
HgenePLA2G6chr22:38565225chr22:38622877ENST00000332509-217677_68669807.0RegionCalmodulin-binding (1-9-14 motif)
HgenePLA2G6chr22:38565225chr22:38622877ENST00000332509-217748_75969807.0RegionCalmodulin-binding (IQ motif)
HgenePLA2G6chr22:38565225chr22:38622877ENST00000335539-216677_68669753.0RegionCalmodulin-binding (1-9-14 motif)
HgenePLA2G6chr22:38565225chr22:38622877ENST00000335539-216748_75969753.0RegionCalmodulin-binding (IQ motif)
HgenePLA2G6chr22:38565225chr22:38622877ENST00000402064-216677_68669753.0RegionCalmodulin-binding (1-9-14 motif)
HgenePLA2G6chr22:38565225chr22:38622877ENST00000402064-216748_75969753.0RegionCalmodulin-binding (IQ motif)
HgenePLA2G6chr22:38565225chr22:38622877ENST00000332509-217120_14769807.0RepeatANK 1
HgenePLA2G6chr22:38565225chr22:38622877ENST00000332509-217151_18169807.0RepeatANK 1
HgenePLA2G6chr22:38565225chr22:38622877ENST00000332509-217185_21569807.0RepeatANK 2
HgenePLA2G6chr22:38565225chr22:38622877ENST00000332509-217219_24869807.0RepeatANK 3
HgenePLA2G6chr22:38565225chr22:38622877ENST00000332509-217251_28169807.0RepeatANK 4
HgenePLA2G6chr22:38565225chr22:38622877ENST00000332509-217286_31269807.0RepeatANK 5
HgenePLA2G6chr22:38565225chr22:38622877ENST00000332509-217316_34569807.0RepeatANK 6
HgenePLA2G6chr22:38565225chr22:38622877ENST00000332509-217349_37869807.0RepeatANK 7
HgenePLA2G6chr22:38565225chr22:38622877ENST00000332509-217382_40369807.0RepeatANK 9
HgenePLA2G6chr22:38565225chr22:38622877ENST00000335539-216120_14769753.0RepeatANK 1
HgenePLA2G6chr22:38565225chr22:38622877ENST00000335539-216151_18169753.0RepeatANK 1
HgenePLA2G6chr22:38565225chr22:38622877ENST00000335539-216185_21569753.0RepeatANK 2
HgenePLA2G6chr22:38565225chr22:38622877ENST00000335539-216219_24869753.0RepeatANK 3
HgenePLA2G6chr22:38565225chr22:38622877ENST00000335539-216251_28169753.0RepeatANK 4
HgenePLA2G6chr22:38565225chr22:38622877ENST00000335539-216286_31269753.0RepeatANK 5
HgenePLA2G6chr22:38565225chr22:38622877ENST00000335539-216316_34569753.0RepeatANK 6
HgenePLA2G6chr22:38565225chr22:38622877ENST00000335539-216349_37869753.0RepeatANK 7
HgenePLA2G6chr22:38565225chr22:38622877ENST00000335539-216382_40369753.0RepeatANK 9
HgenePLA2G6chr22:38565225chr22:38622877ENST00000402064-216120_14769753.0RepeatANK 1
HgenePLA2G6chr22:38565225chr22:38622877ENST00000402064-216151_18169753.0RepeatANK 1
HgenePLA2G6chr22:38565225chr22:38622877ENST00000402064-216185_21569753.0RepeatANK 2
HgenePLA2G6chr22:38565225chr22:38622877ENST00000402064-216219_24869753.0RepeatANK 3
HgenePLA2G6chr22:38565225chr22:38622877ENST00000402064-216251_28169753.0RepeatANK 4
HgenePLA2G6chr22:38565225chr22:38622877ENST00000402064-216286_31269753.0RepeatANK 5
HgenePLA2G6chr22:38565225chr22:38622877ENST00000402064-216316_34569753.0RepeatANK 6
HgenePLA2G6chr22:38565225chr22:38622877ENST00000402064-216349_37869753.0RepeatANK 7
HgenePLA2G6chr22:38565225chr22:38622877ENST00000402064-216382_40369753.0RepeatANK 9
HgenePLA2G6chr22:38565225chr22:38622877ENST00000332509-217480_50069807.0TransmembraneHelical
HgenePLA2G6chr22:38565225chr22:38622877ENST00000332509-217511_53169807.0TransmembraneHelical
HgenePLA2G6chr22:38565225chr22:38622877ENST00000335539-216480_50069753.0TransmembraneHelical
HgenePLA2G6chr22:38565225chr22:38622877ENST00000335539-216511_53169753.0TransmembraneHelical
HgenePLA2G6chr22:38565225chr22:38622877ENST00000402064-216480_50069753.0TransmembraneHelical
HgenePLA2G6chr22:38565225chr22:38622877ENST00000402064-216511_53169753.0TransmembraneHelical
TgeneTMEM184Bchr22:38565225chr22:38622877ENST0000036168449121_141175408.0TransmembraneHelical
TgeneTMEM184Bchr22:38565225chr22:38622877ENST000003616844940_60175408.0TransmembraneHelical
TgeneTMEM184Bchr22:38565225chr22:38622877ENST000003616844984_104175408.0TransmembraneHelical
TgeneTMEM184Bchr22:38565225chr22:38622877ENST0000036190649121_141175408.0TransmembraneHelical
TgeneTMEM184Bchr22:38565225chr22:38622877ENST000003619064940_60175408.0TransmembraneHelical
TgeneTMEM184Bchr22:38565225chr22:38622877ENST000003619064984_104175408.0TransmembraneHelical


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Fusion Gene Sequence for PLA2G6-TMEM184B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for PLA2G6-TMEM184B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PLA2G6-TMEM184B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PLA2G6-TMEM184B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource