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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PLAUR-AAMDC (FusionGDB2 ID:65923)

Fusion Gene Summary for PLAUR-AAMDC

check button Fusion gene summary
Fusion gene informationFusion gene name: PLAUR-AAMDC
Fusion gene ID: 65923
HgeneTgene
Gene symbol

PLAUR

AAMDC

Gene ID

5329

28971

Gene nameplasminogen activator, urokinase receptoradipogenesis associated Mth938 domain containing
SynonymsCD87|U-PAR|UPAR|URKRC11orf67|CK067|PTD015
Cytomap

19q13.31

11q14.1

Type of geneprotein-codingprotein-coding
Descriptionurokinase plasminogen activator surface receptormonocyte activation antigen Mo3u-plasminogen activator receptor form 2urokinase-type plasminogen activator (uPA) receptormth938 domain-containing proteinUPF0366 protein C11orf67adipogenesis associated Mth938 domain-containing protein
Modification date2020032920200313
UniProtAcc.

Q9H7C9

Ensembl transtripts involved in fusion geneENST00000221264, ENST00000339082, 
ENST00000340093, ENST00000601723, 
ENST00000304716, ENST00000393427, 
ENST00000525034, ENST00000525409, 
ENST00000526415, ENST00000527134, 
ENST00000531855, ENST00000533193, 
ENST00000532481, 
Fusion gene scores* DoF score9 X 6 X 8=4328 X 6 X 5=240
# samples 109
** MAII scorelog2(10/432*10)=-2.11103131238874
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/240*10)=-1.41503749927884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PLAUR [Title/Abstract] AND AAMDC [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPLAUR(44174218)-AAMDC(77629107), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePLAUR

GO:0043388

positive regulation of DNA binding

22984561


check buttonFusion gene breakpoints across PLAUR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across AAMDC (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A1-A0SQ-01APLAURchr19

44174218

-AAMDCchr11

77629107

+


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Fusion Gene ORF analysis for PLAUR-AAMDC

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000221264ENST00000304716PLAURchr19

44174218

-AAMDCchr11

77629107

+
5CDS-intronENST00000221264ENST00000393427PLAURchr19

44174218

-AAMDCchr11

77629107

+
5CDS-intronENST00000221264ENST00000525034PLAURchr19

44174218

-AAMDCchr11

77629107

+
5CDS-intronENST00000221264ENST00000525409PLAURchr19

44174218

-AAMDCchr11

77629107

+
5CDS-intronENST00000221264ENST00000526415PLAURchr19

44174218

-AAMDCchr11

77629107

+
5CDS-intronENST00000221264ENST00000527134PLAURchr19

44174218

-AAMDCchr11

77629107

+
5CDS-intronENST00000221264ENST00000531855PLAURchr19

44174218

-AAMDCchr11

77629107

+
5CDS-intronENST00000221264ENST00000533193PLAURchr19

44174218

-AAMDCchr11

77629107

+
5CDS-intronENST00000339082ENST00000304716PLAURchr19

44174218

-AAMDCchr11

77629107

+
5CDS-intronENST00000339082ENST00000393427PLAURchr19

44174218

-AAMDCchr11

77629107

+
5CDS-intronENST00000339082ENST00000525034PLAURchr19

44174218

-AAMDCchr11

77629107

+
5CDS-intronENST00000339082ENST00000525409PLAURchr19

44174218

-AAMDCchr11

77629107

+
5CDS-intronENST00000339082ENST00000526415PLAURchr19

44174218

-AAMDCchr11

77629107

+
5CDS-intronENST00000339082ENST00000527134PLAURchr19

44174218

-AAMDCchr11

77629107

+
5CDS-intronENST00000339082ENST00000531855PLAURchr19

44174218

-AAMDCchr11

77629107

+
5CDS-intronENST00000339082ENST00000533193PLAURchr19

44174218

-AAMDCchr11

77629107

+
5CDS-intronENST00000340093ENST00000304716PLAURchr19

44174218

-AAMDCchr11

77629107

+
5CDS-intronENST00000340093ENST00000393427PLAURchr19

44174218

-AAMDCchr11

77629107

+
5CDS-intronENST00000340093ENST00000525034PLAURchr19

44174218

-AAMDCchr11

77629107

+
5CDS-intronENST00000340093ENST00000525409PLAURchr19

44174218

-AAMDCchr11

77629107

+
5CDS-intronENST00000340093ENST00000526415PLAURchr19

44174218

-AAMDCchr11

77629107

+
5CDS-intronENST00000340093ENST00000527134PLAURchr19

44174218

-AAMDCchr11

77629107

+
5CDS-intronENST00000340093ENST00000531855PLAURchr19

44174218

-AAMDCchr11

77629107

+
5CDS-intronENST00000340093ENST00000533193PLAURchr19

44174218

-AAMDCchr11

77629107

+
5CDS-intronENST00000601723ENST00000304716PLAURchr19

44174218

-AAMDCchr11

77629107

+
5CDS-intronENST00000601723ENST00000393427PLAURchr19

44174218

-AAMDCchr11

77629107

+
5CDS-intronENST00000601723ENST00000525034PLAURchr19

44174218

-AAMDCchr11

77629107

+
5CDS-intronENST00000601723ENST00000525409PLAURchr19

44174218

-AAMDCchr11

77629107

+
5CDS-intronENST00000601723ENST00000526415PLAURchr19

44174218

-AAMDCchr11

77629107

+
5CDS-intronENST00000601723ENST00000527134PLAURchr19

44174218

-AAMDCchr11

77629107

+
5CDS-intronENST00000601723ENST00000531855PLAURchr19

44174218

-AAMDCchr11

77629107

+
5CDS-intronENST00000601723ENST00000533193PLAURchr19

44174218

-AAMDCchr11

77629107

+
In-frameENST00000221264ENST00000532481PLAURchr19

44174218

-AAMDCchr11

77629107

+
In-frameENST00000339082ENST00000532481PLAURchr19

44174218

-AAMDCchr11

77629107

+
In-frameENST00000340093ENST00000532481PLAURchr19

44174218

-AAMDCchr11

77629107

+
In-frameENST00000601723ENST00000532481PLAURchr19

44174218

-AAMDCchr11

77629107

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000339082PLAURchr1944174218-ENST00000532481AAMDCchr1177629107+4731014629482
ENST00000601723PLAURchr1944174218-ENST00000532481AAMDCchr1177629107+460883328182
ENST00000340093PLAURchr1944174218-ENST00000532481AAMDCchr1177629107+657285170478102
ENST00000221264PLAURchr1944174218-ENST00000532481AAMDCchr1177629107+854482502125125

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000339082ENST00000532481PLAURchr1944174218-AAMDCchr1177629107+0.43259440.5674056
ENST00000601723ENST00000532481PLAURchr1944174218-AAMDCchr1177629107+0.468042940.53195703
ENST00000340093ENST00000532481PLAURchr1944174218-AAMDCchr1177629107+0.475559030.52444094
ENST00000221264ENST00000532481PLAURchr1944174218-AAMDCchr1177629107+0.558858630.4411414

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Fusion Genomic Features for PLAUR-AAMDC


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PLAURchr1944174217-AAMDCchr1177629106+8.62E-060.9999914
PLAURchr1944174217-AAMDCchr1177629106+8.62E-060.9999914

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PLAUR-AAMDC


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:44174218/chr11:77629107)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.AAMDC

Q9H7C9

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: May play a role in preadipocyte differentiation and adipogenesis. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneAAMDCchr19:44174218chr11:77629107ENST00000393427046_1220123.0RegionMTH138-like domain
TgeneAAMDCchr19:44174218chr11:77629107ENST00000526415056_1220123.0RegionMTH138-like domain

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePLAURchr19:44174218chr11:77629107ENST00000221264-16115_21318291.0DomainNote=UPAR/Ly6 2
HgenePLAURchr19:44174218chr11:77629107ENST00000221264-16214_30518291.0DomainNote=UPAR/Ly6 3
HgenePLAURchr19:44174218chr11:77629107ENST00000221264-1623_11418291.0DomainNote=UPAR/Ly6 1
HgenePLAURchr19:44174218chr11:77629107ENST00000339082-17115_21318282.0DomainNote=UPAR/Ly6 2
HgenePLAURchr19:44174218chr11:77629107ENST00000339082-17214_30518282.0DomainNote=UPAR/Ly6 3
HgenePLAURchr19:44174218chr11:77629107ENST00000339082-1723_11418282.0DomainNote=UPAR/Ly6 1
HgenePLAURchr19:44174218chr11:77629107ENST00000340093-17115_21318336.0DomainNote=UPAR/Ly6 2
HgenePLAURchr19:44174218chr11:77629107ENST00000340093-17214_30518336.0DomainNote=UPAR/Ly6 3
HgenePLAURchr19:44174218chr11:77629107ENST00000340093-1723_11418336.0DomainNote=UPAR/Ly6 1
TgeneAAMDCchr19:44174218chr11:77629107ENST00000532481246_1227689.0RegionMTH138-like domain


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Fusion Gene Sequence for PLAUR-AAMDC


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>65923_65923_1_PLAUR-AAMDC_PLAUR_chr19_44174218_ENST00000221264_AAMDC_chr11_77629107_ENST00000532481_length(transcript)=854nt_BP=482nt
CAGTATCCCTCCTGACAAAACTAACAAAAATCCTGTTAGCCAAATAATCAGCCACATTCATATTTACCGTCAAAGTTTTTATCCTCATTT
TACAGCAGTGGAGAGCGATTGCCCCGGGTCCCACGTTAGGAAGAGAGAGAACTGGGATTTGCACCCAGGCAATCTGGGGACAGAGCTGTG
ATCACAACTCCATGAGTCAGGGCCGAGCCAGCCCCTTCACCACCAGCCGGCCGCGCCCCGGGAAGGGAAGTTTGTGGCGGAGGAGGTTCG
TACGGGAGGAGGGGGAGGCGCCCACGCATCTGGGGCTGACTCGCTCTTTCGCAAAACGTCTGGGAGGAGTCCCTGGGGCCACAAAACTGC
CTCCTTCCTGAGGCCAGAAGGAGAGAAGACGTGCAGGGACCCCGCGCACAGGAGCTGCCCTCGCGACATGGGTCACCCGCCGCTGCTGCC
GCTGCTGCTGCTGCTCCACACCTGCGTCCCAGGATGGAATACAGGGGGCACAGTTAGATCTGAATTGTTAAGCAGAGGCTGCTTGATGCA
GAAGATGAAGACAGAAGAAAGAATGAGCCTAGGCCGGGCACAGTGGCTCACGCCTGTAATTCCAGCACTTTGGGAGGCCGAGGCGGGAGG
ATCACTTGAGCTCAGGAGTTTGAGACCAGCCTGGCCACCATGGTGAAACCTCGACTCTACAAAAAAAAAAAAGCCAAAATTAGCCAGGTG
TGGTGGCATATGCCTGTGGTCCCAGCTACTTGGGAGGCTGAAGTGGGAGAATCACTTGCAGTGAGCTGATATTATGCCACTGCACTCCAG

>65923_65923_1_PLAUR-AAMDC_PLAUR_chr19_44174218_ENST00000221264_AAMDC_chr11_77629107_ENST00000532481_length(amino acids)=125AA_BP=
MCPLYSILGRRCGAAAAAAAAAGDPCREGSSCARGPCTSSLLLASGRRQFCGPRDSSQTFCERASQPQMRGRLPLLPYEPPPPQTSLPGA

--------------------------------------------------------------
>65923_65923_2_PLAUR-AAMDC_PLAUR_chr19_44174218_ENST00000339082_AAMDC_chr11_77629107_ENST00000532481_length(transcript)=473nt_BP=101nt
AGAGAAGACGTGCAGGGACCCCGCGCACAGGAGCTGCCCTCGCGACATGGGTCACCCGCCGCTGCTGCCGCTGCTGCTGCTGCTCCACAC
CTGCGTCCCAGGATGGAATACAGGGGGCACAGTTAGATCTGAATTGTTAAGCAGAGGCTGCTTGATGCAGAAGATGAAGACAGAAGAAAG
AATGAGCCTAGGCCGGGCACAGTGGCTCACGCCTGTAATTCCAGCACTTTGGGAGGCCGAGGCGGGAGGATCACTTGAGCTCAGGAGTTT
GAGACCAGCCTGGCCACCATGGTGAAACCTCGACTCTACAAAAAAAAAAAAGCCAAAATTAGCCAGGTGTGGTGGCATATGCCTGTGGTC
CCAGCTACTTGGGAGGCTGAAGTGGGAGAATCACTTGCAGTGAGCTGATATTATGCCACTGCACTCCAGCCTGGGTGACAGGGTGAGACC

>65923_65923_2_PLAUR-AAMDC_PLAUR_chr19_44174218_ENST00000339082_AAMDC_chr11_77629107_ENST00000532481_length(amino acids)=82AA_BP=18

--------------------------------------------------------------
>65923_65923_3_PLAUR-AAMDC_PLAUR_chr19_44174218_ENST00000340093_AAMDC_chr11_77629107_ENST00000532481_length(transcript)=657nt_BP=285nt
CAGGGCCGAGCCAGCCCCTTCACCACCAGCCGGCCGCGCCCCGGGAAGGGAAGTTTGTGGCGGAGGAGGTTCGTACGGGAGGAGGGGGAG
GCGCCCACGCATCTGGGGCTGACTCGCTCTTTCGCAAAACGTCTGGGAGGAGTCCCTGGGGCCACAAAACTGCCTCCTTCCTGAGGCCAG
AAGGAGAGAAGACGTGCAGGGACCCCGCGCACAGGAGCTGCCCTCGCGACATGGGTCACCCGCCGCTGCTGCCGCTGCTGCTGCTGCTCC
ACACCTGCGTCCCAGGATGGAATACAGGGGGCACAGTTAGATCTGAATTGTTAAGCAGAGGCTGCTTGATGCAGAAGATGAAGACAGAAG
AAAGAATGAGCCTAGGCCGGGCACAGTGGCTCACGCCTGTAATTCCAGCACTTTGGGAGGCCGAGGCGGGAGGATCACTTGAGCTCAGGA
GTTTGAGACCAGCCTGGCCACCATGGTGAAACCTCGACTCTACAAAAAAAAAAAAGCCAAAATTAGCCAGGTGTGGTGGCATATGCCTGT
GGTCCCAGCTACTTGGGAGGCTGAAGTGGGAGAATCACTTGCAGTGAGCTGATATTATGCCACTGCACTCCAGCCTGGGTGACAGGGTGA

>65923_65923_3_PLAUR-AAMDC_PLAUR_chr19_44174218_ENST00000340093_AAMDC_chr11_77629107_ENST00000532481_length(amino acids)=102AA_BP=38
MRPEGEKTCRDPAHRSCPRDMGHPPLLPLLLLLHTCVPGWNTGGTVRSELLSRGCLMQKMKTEERMSLGRAQWLTPVIPALWEAEAGGSL

--------------------------------------------------------------
>65923_65923_4_PLAUR-AAMDC_PLAUR_chr19_44174218_ENST00000601723_AAMDC_chr11_77629107_ENST00000532481_length(transcript)=460nt_BP=88nt
AGGGACCCCGCGCACAGGAGCTGCCCTCGCGACATGGGTCACCCGCCGCTGCTGCCGCTGCTGCTGCTGCTCCACACCTGCGTCCCAGGA
TGGAATACAGGGGGCACAGTTAGATCTGAATTGTTAAGCAGAGGCTGCTTGATGCAGAAGATGAAGACAGAAGAAAGAATGAGCCTAGGC
CGGGCACAGTGGCTCACGCCTGTAATTCCAGCACTTTGGGAGGCCGAGGCGGGAGGATCACTTGAGCTCAGGAGTTTGAGACCAGCCTGG
CCACCATGGTGAAACCTCGACTCTACAAAAAAAAAAAAGCCAAAATTAGCCAGGTGTGGTGGCATATGCCTGTGGTCCCAGCTACTTGGG
AGGCTGAAGTGGGAGAATCACTTGCAGTGAGCTGATATTATGCCACTGCACTCCAGCCTGGGTGACAGGGTGAGACCCTGTCTCAAAAAA

>65923_65923_4_PLAUR-AAMDC_PLAUR_chr19_44174218_ENST00000601723_AAMDC_chr11_77629107_ENST00000532481_length(amino acids)=82AA_BP=18

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PLAUR-AAMDC


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PLAUR-AAMDC


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PLAUR-AAMDC


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource