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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PLAUR-MARK4 (FusionGDB2 ID:65926)

Fusion Gene Summary for PLAUR-MARK4

check button Fusion gene summary
Fusion gene informationFusion gene name: PLAUR-MARK4
Fusion gene ID: 65926
HgeneTgene
Gene symbol

PLAUR

MARK4

Gene ID

5329

57787

Gene nameplasminogen activator, urokinase receptormicrotubule affinity regulating kinase 4
SynonymsCD87|U-PAR|UPAR|URKRMARK4L|MARK4S|MARKL1|MARKL1L|PAR-1D
Cytomap

19q13.31

19q13.32

Type of geneprotein-codingprotein-coding
Descriptionurokinase plasminogen activator surface receptormonocyte activation antigen Mo3u-plasminogen activator receptor form 2urokinase-type plasminogen activator (uPA) receptorMAP/microtubule affinity-regulating kinase 4MAP/microtubule affinity-regulating kinase like 1MARK4 serine/threonine protein kinaseepididymis secretory sperm binding protein
Modification date2020032920200313
UniProtAcc.

Q96L34

Ensembl transtripts involved in fusion geneENST00000221264, ENST00000339082, 
ENST00000340093, ENST00000601723, 
ENST00000262891, ENST00000300843, 
Fusion gene scores* DoF score9 X 6 X 8=4325 X 5 X 3=75
# samples 105
** MAII scorelog2(10/432*10)=-2.11103131238874
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PLAUR [Title/Abstract] AND MARK4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPLAUR(44174218)-MARK4(45762247), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePLAUR

GO:0043388

positive regulation of DNA binding

22984561

TgeneMARK4

GO:0007399

nervous system development

14594945


check buttonFusion gene breakpoints across PLAUR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MARK4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LAMLTCGA-AB-3007-03APLAURchr19

44174218

-MARK4chr19

45762247

+


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Fusion Gene ORF analysis for PLAUR-MARK4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000221264ENST00000262891PLAURchr19

44174218

-MARK4chr19

45762247

+
In-frameENST00000221264ENST00000300843PLAURchr19

44174218

-MARK4chr19

45762247

+
In-frameENST00000339082ENST00000262891PLAURchr19

44174218

-MARK4chr19

45762247

+
In-frameENST00000339082ENST00000300843PLAURchr19

44174218

-MARK4chr19

45762247

+
In-frameENST00000340093ENST00000262891PLAURchr19

44174218

-MARK4chr19

45762247

+
In-frameENST00000340093ENST00000300843PLAURchr19

44174218

-MARK4chr19

45762247

+
In-frameENST00000601723ENST00000262891PLAURchr19

44174218

-MARK4chr19

45762247

+
In-frameENST00000601723ENST00000300843PLAURchr19

44174218

-MARK4chr19

45762247

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000339082PLAURchr1944174218-ENST00000262891MARK4chr1945762247+32921011102308732
ENST00000339082PLAURchr1944174218-ENST00000300843MARK4chr1945762247+49621011102116668
ENST00000601723PLAURchr1944174218-ENST00000262891MARK4chr1945762247+327988972295732
ENST00000601723PLAURchr1944174218-ENST00000300843MARK4chr1945762247+494988972103668
ENST00000340093PLAURchr1944174218-ENST00000262891MARK4chr1945762247+34762852942492732
ENST00000340093PLAURchr1944174218-ENST00000300843MARK4chr1945762247+51462852942300668
ENST00000221264PLAURchr1944174218-ENST00000262891MARK4chr1945762247+36734824912689732
ENST00000221264PLAURchr1944174218-ENST00000300843MARK4chr1945762247+53434824912497668

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000339082ENST00000262891PLAURchr1944174218-MARK4chr1945762247+0.0458556530.95414436
ENST00000339082ENST00000300843PLAURchr1944174218-MARK4chr1945762247+0.0150036380.9849963
ENST00000601723ENST00000262891PLAURchr1944174218-MARK4chr1945762247+0.044999630.9550004
ENST00000601723ENST00000300843PLAURchr1944174218-MARK4chr1945762247+0.0147215720.98527837
ENST00000340093ENST00000262891PLAURchr1944174218-MARK4chr1945762247+0.0414023920.9585976
ENST00000340093ENST00000300843PLAURchr1944174218-MARK4chr1945762247+0.014431920.98556817
ENST00000221264ENST00000262891PLAURchr1944174218-MARK4chr1945762247+0.0402245860.95977545
ENST00000221264ENST00000300843PLAURchr1944174218-MARK4chr1945762247+0.0142242520.98577577

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Fusion Genomic Features for PLAUR-MARK4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PLAURchr1944174217-MARK4chr1945762246+8.47E-060.99999154
PLAURchr1944174217-MARK4chr1945762246+8.47E-060.99999154

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PLAUR-MARK4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:44174218/chr19:45762247)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MARK4

Q96L34

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Serine/threonine-protein kinase (PubMed:15009667, PubMed:14594945, PubMed:23666762, PubMed:23184942). Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:14594945, PubMed:23666762). Also phosphorylates the microtubule-associated proteins MAP2 and MAP4 (PubMed:14594945). Involved in regulation of the microtubule network, causing reorganization of microtubules into bundles (PubMed:14594945, PubMed:25123532). Required for the initiation of axoneme extension during cilium assembly (PubMed:23400999). Regulates the centrosomal location of ODF2 and phosphorylates ODF2 in vitro (PubMed:23400999). Plays a role in cell cycle progression, specifically in the G1/S checkpoint (PubMed:25123532). Reduces neuronal cell survival (PubMed:15009667). Plays a role in energy homeostasis by regulating satiety and metabolic rate (By similarity). Promotes adipogenesis by activating JNK1 and inhibiting the p38MAPK pathway, and triggers apoptosis by activating the JNK1 pathway (By similarity). Phosphorylates mTORC1 complex member RPTOR and acts as a negative regulator of the mTORC1 complex, probably due to disruption of the interaction between phosphorylated RPTOR and the RRAGA/RRAGC heterodimer which is required for mTORC1 activation (PubMed:23184942). {ECO:0000250|UniProtKB:Q8CIP4, ECO:0000269|PubMed:14594945, ECO:0000269|PubMed:15009667, ECO:0000269|PubMed:23184942, ECO:0000269|PubMed:23400999, ECO:0000269|PubMed:23666762, ECO:0000269|PubMed:25123532}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMARK4chr19:44174218chr19:45762247ENST00000262891017324_36817753.0DomainUBA
TgeneMARK4chr19:44174218chr19:45762247ENST0000026289101759_31017753.0DomainProtein kinase
TgeneMARK4chr19:44174218chr19:45762247ENST00000262891017703_75217753.0DomainKA1
TgeneMARK4chr19:44174218chr19:45762247ENST00000300843018324_36817689.0DomainUBA
TgeneMARK4chr19:44174218chr19:45762247ENST0000030084301859_31017689.0DomainProtein kinase
TgeneMARK4chr19:44174218chr19:45762247ENST00000300843018703_75217689.0DomainKA1
TgeneMARK4chr19:44174218chr19:45762247ENST0000026289101765_7317753.0Nucleotide bindingATP
TgeneMARK4chr19:44174218chr19:45762247ENST0000030084301865_7317689.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePLAURchr19:44174218chr19:45762247ENST00000221264-16115_21318291.0DomainNote=UPAR/Ly6 2
HgenePLAURchr19:44174218chr19:45762247ENST00000221264-16214_30518291.0DomainNote=UPAR/Ly6 3
HgenePLAURchr19:44174218chr19:45762247ENST00000221264-1623_11418291.0DomainNote=UPAR/Ly6 1
HgenePLAURchr19:44174218chr19:45762247ENST00000339082-17115_21318282.0DomainNote=UPAR/Ly6 2
HgenePLAURchr19:44174218chr19:45762247ENST00000339082-17214_30518282.0DomainNote=UPAR/Ly6 3
HgenePLAURchr19:44174218chr19:45762247ENST00000339082-1723_11418282.0DomainNote=UPAR/Ly6 1
HgenePLAURchr19:44174218chr19:45762247ENST00000340093-17115_21318336.0DomainNote=UPAR/Ly6 2
HgenePLAURchr19:44174218chr19:45762247ENST00000340093-17214_30518336.0DomainNote=UPAR/Ly6 3
HgenePLAURchr19:44174218chr19:45762247ENST00000340093-1723_11418336.0DomainNote=UPAR/Ly6 1


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Fusion Gene Sequence for PLAUR-MARK4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>65926_65926_1_PLAUR-MARK4_PLAUR_chr19_44174218_ENST00000221264_MARK4_chr19_45762247_ENST00000262891_length(transcript)=3673nt_BP=482nt
CAGTATCCCTCCTGACAAAACTAACAAAAATCCTGTTAGCCAAATAATCAGCCACATTCATATTTACCGTCAAAGTTTTTATCCTCATTT
TACAGCAGTGGAGAGCGATTGCCCCGGGTCCCACGTTAGGAAGAGAGAGAACTGGGATTTGCACCCAGGCAATCTGGGGACAGAGCTGTG
ATCACAACTCCATGAGTCAGGGCCGAGCCAGCCCCTTCACCACCAGCCGGCCGCGCCCCGGGAAGGGAAGTTTGTGGCGGAGGAGGTTCG
TACGGGAGGAGGGGGAGGCGCCCACGCATCTGGGGCTGACTCGCTCTTTCGCAAAACGTCTGGGAGGAGTCCCTGGGGCCACAAAACTGC
CTCCTTCCTGAGGCCAGAAGGAGAGAAGACGTGCAGGGACCCCGCGCACAGGAGCTGCCCTCGCGACATGGGTCACCCGCCGCTGCTGCC
GCTGCTGCTGCTGCTCCACACCTGCGTCCCAGCATGGCACCTTGGGCAGTGGCCGCTCCTCGGACAAAGGCCCGTCCTGGTCCAGCCGCT
CACTGGGTGCCCGTTGCCGGAACTCCATCGCCTCCTGTCCCGAGGAGCAGCCCCACGTGGGCAACTACCGCCTGCTGAGGACCATTGGGA
AGGGCAACTTTGCCAAAGTCAAGCTGGCTCGGCACATCCTCACTGGTCGGGAGGTTGCCATCAAGATTATCGACAAAACCCAGCTGAATC
CCAGCAGCCTGCAGAAGCTGTTCCGAGAAGTCCGCATCATGAAGGGCCTAAACCACCCCAACATCGTGAAGCTCTTTGAGGTGATTGAGA
CTGAGAAGACGCTGTACCTGGTGATGGAGTACGCAAGTGCTGGAGAAGTGTTTGACTACCTCGTGTCGCATGGCCGCATGAAGGAGAAGG
AAGCTCGAGCCAAGTTCCGACAGATTGTTTCGGCTGTGCACTATTGTCACCAGAAAAATATTGTACACAGGGACCTGAAGGCTGAGAACC
TCTTGCTGGATGCCGAGGCCAACATCAAGATTGCTGACTTTGGCTTCAGCAACGAGTTCACGCTGGGATCGAAGCTGGACACGTTCTGCG
GGAGCCCCCCATATGCCGCCCCGGAGCTGTTTCAGGGCAAGAAGTACGACGGGCCGGAGGTGGACATCTGGAGCCTGGGAGTCATCCTGT
ACACCCTCGTCAGCGGCTCCCTGCCCTTCGACGGGCACAACCTCAAGGAGCTGCGGGAGCGAGTACTCAGAGGGAAGTACCGGGTCCCTT
TCTACATGTCAACAGACTGTGAGAGCATCCTGCGGAGATTTTTGGTGCTGAACCCAGCTAAACGCTGTACTCTCGAGCAAATCATGAAAG
ACAAATGGATCAACATCGGCTATGAGGGTGAGGAGTTGAAGCCATACACAGAGCCCGAGGAGGACTTCGGGGACACCAAGAGAATTGAGG
TGATGGTGGGTATGGGCTACACACGGGAAGAAATCAAAGAGTCCTTGACCAGCCAGAAGTACAACGAAGTGACCGCCACCTACCTCCTGC
TGGGCAGGAAGACTGAGGAGGGTGGGGACCGGGGCGCCCCAGGGCTGGCCCTGGCACGGGTGCGGGCGCCCAGCGACACCACCAACGGAA
CAAGTTCCAGCAAAGGCACCAGCCACAGCAAAGGGCAGCGGAGTTCCTCTTCCACCTACCACCGCCAGCGCAGGCATAGCGATTTCTGTG
GCCCATCCCCTGCACCCCTGCACCCCAAACGCAGCCCGACGAGCACGGGGGAGGCGGAGCTGAAGGAGGAGCGGCTGCCAGGCCGGAAGG
CGAGCTGCAGCACCGCGGGGAGTGGGAGTCGAGGGCTGCCCCCCTCCAGCCCCATGGTCAGCAGCGCCCACAACCCCAACAAGGCAGAGA
TCCCAGAGCGGCGGAAGGACAGCACGAGCACCCCCAACAACCTCCCTCCTAGCATGATGACCCGCAGAAACACCTACGTTTGCACAGAAC
GCCCGGGGGCTGAGCGCCCGTCACTGTTGCCAAATGGGAAAGAAAACAGCTCAGGCACCCCACGGGTGCCCCCTGCCTCCCCCTCCAGTC
ACAGCCTGGCACCCCCATCAGGGGAGCGGAGCCGCCTGGCACGTGGTTCCACCATCCGCAGCACCTTCCATGGTGGCCAGGTCCGGGACC
GGCGGGCAGGGGGTGGGGGTGGTGGGGGTGTGCAGAATGGGCCCCCTGCCTCTCCCACACTGGCCCATGAGGCTGCACCCCTGCCCGCCG
GGCGGCCCCGCCCCACCACCAACCTCTTCACCAAGCTGACCTCCAAACTGACCCGAAGGGTCGCAGACGAACCTGAGAGAATCGGGGGAC
CTGAGGTCACAAGTTGCCATCTACCTTGGGATCAAACGGAAACCGCCCCCCGGCTGCTCCGATTCCCCTGGAGTGTGAAGCTGACCAGCT
CGCGCCCTCCTGAGGCCCTGATGGCAGCTCTGCGCCAGGCCACAGCAGCCGCCCGCTGCCGCTGCCGCCAGCCACAGCCGTTCCTGCTGG
CCTGCCTGCACGGGGGTGCGGGCGGGCCCGAGCCCCTGTCCCACTTCGAAGTGGAGGTCTGCCAGCTGCCCCGGCCAGGCTTGCGGGGAG
TTCTCTTCCGCCGTGTGGCGGGCACCGCCCTGGCCTTCCGCACCCTCGTCACCCGCATCTCCAACGACCTCGAGCTCTGAGCCACCACGG
TCCCAGGGCCCTTACTCTTCCTCTCCCTTGTCGCCTTCACTTCTACAGGAGGGGAAGGGGCCAGGGAGGGGATTCTCCCTTTATCATCAC
CTCAGTTTCCCTGAATTATATTTGGGGGCAAAGATTGTCCCCTCTGCTGTTCTCTGGGGCCGCTCAGCACAGAAGAAGGATGAGGGGGCT
CAGCGGGGGGAGCTGGCACCTTCCTGGAGCCTCCAGCCAGTCCTGTCCTCCCTCGCCCTACCAAGAGGGCACCTGAGGAGACTTTGGGGA
CAGGGCAGGGGCAGGGAGGGAAACTGAGGAAATCTTCCATTCCTCCCAACAGCTCAAAATTAGGCCTTGGGCAGGGGCAGGGAGAGCTGC
TGAGCCTAAAGACTGGAGAATCTGGGGGACTGGGAGTGGGGGTCAGAGAGGCAGATTCCTTCCCCTCCCGTCCCCTCACGCTCAAACCCC
CACTTCCTGCCCCAGGCTGGCGCGGGGCACTTTGTACAAATCCTTGTAAATACCCCACACCCTCCCCTCTGCAAAGGTCTCTTGAGGAGC
TGCCGCTGTCACCTACGGTTTTTAAGTTATTACACCCCGACCCTCCTCCTGTCAGCCCCCTCACCTGCAGCCTGTTGCCCAATAAATTTA
AGAGAGTCCCCCCCTCCCCAATGCTGACCCTAGGATTTTCCTTCCCTGCCCTCACCTGCAAATGAGTTAAAGAAGAGGCGTGGGAATCCA
GGCAGTGGTTTTTCCTTTCGGAGCCTCGGTTTTCTCATCTGCAGAATGGGAGCGGTGGGGGTGGGAAGGTAAGGATGGTCGTGGAAGAAG
GCAGGATGGAACTCGGCCTCATCCCCGAGGCCCCAGTTCCTATATCGGGCCCCCCATTCATCCACTCACACTCCCAGCCACCATGTTACA

>65926_65926_1_PLAUR-MARK4_PLAUR_chr19_44174218_ENST00000221264_MARK4_chr19_45762247_ENST00000262891_length(amino acids)=732AA_BP=
MGSGRSSDKGPSWSSRSLGARCRNSIASCPEEQPHVGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIM
KGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADF
GFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRF
LVLNPAKRCTLEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKESLTSQKYNEVTATYLLLGRKTEEGGDRGAP
GLALARVRAPSDTTNGTSSSKGTSHSKGQRSSSSTYHRQRRHSDFCGPSPAPLHPKRSPTSTGEAELKEERLPGRKASCSTAGSGSRGLP
PSSPMVSSAHNPNKAEIPERRKDSTSTPNNLPPSMMTRRNTYVCTERPGAERPSLLPNGKENSSGTPRVPPASPSSHSLAPPSGERSRLA
RGSTIRSTFHGGQVRDRRAGGGGGGGVQNGPPASPTLAHEAAPLPAGRPRPTTNLFTKLTSKLTRRVADEPERIGGPEVTSCHLPWDQTE
TAPRLLRFPWSVKLTSSRPPEALMAALRQATAAARCRCRQPQPFLLACLHGGAGGPEPLSHFEVEVCQLPRPGLRGVLFRRVAGTALAFR

--------------------------------------------------------------
>65926_65926_2_PLAUR-MARK4_PLAUR_chr19_44174218_ENST00000221264_MARK4_chr19_45762247_ENST00000300843_length(transcript)=5343nt_BP=482nt
CAGTATCCCTCCTGACAAAACTAACAAAAATCCTGTTAGCCAAATAATCAGCCACATTCATATTTACCGTCAAAGTTTTTATCCTCATTT
TACAGCAGTGGAGAGCGATTGCCCCGGGTCCCACGTTAGGAAGAGAGAGAACTGGGATTTGCACCCAGGCAATCTGGGGACAGAGCTGTG
ATCACAACTCCATGAGTCAGGGCCGAGCCAGCCCCTTCACCACCAGCCGGCCGCGCCCCGGGAAGGGAAGTTTGTGGCGGAGGAGGTTCG
TACGGGAGGAGGGGGAGGCGCCCACGCATCTGGGGCTGACTCGCTCTTTCGCAAAACGTCTGGGAGGAGTCCCTGGGGCCACAAAACTGC
CTCCTTCCTGAGGCCAGAAGGAGAGAAGACGTGCAGGGACCCCGCGCACAGGAGCTGCCCTCGCGACATGGGTCACCCGCCGCTGCTGCC
GCTGCTGCTGCTGCTCCACACCTGCGTCCCAGCATGGCACCTTGGGCAGTGGCCGCTCCTCGGACAAAGGCCCGTCCTGGTCCAGCCGCT
CACTGGGTGCCCGTTGCCGGAACTCCATCGCCTCCTGTCCCGAGGAGCAGCCCCACGTGGGCAACTACCGCCTGCTGAGGACCATTGGGA
AGGGCAACTTTGCCAAAGTCAAGCTGGCTCGGCACATCCTCACTGGTCGGGAGGTTGCCATCAAGATTATCGACAAAACCCAGCTGAATC
CCAGCAGCCTGCAGAAGCTGTTCCGAGAAGTCCGCATCATGAAGGGCCTAAACCACCCCAACATCGTGAAGCTCTTTGAGGTGATTGAGA
CTGAGAAGACGCTGTACCTGGTGATGGAGTACGCAAGTGCTGGAGAAGTGTTTGACTACCTCGTGTCGCATGGCCGCATGAAGGAGAAGG
AAGCTCGAGCCAAGTTCCGACAGATTGTTTCGGCTGTGCACTATTGTCACCAGAAAAATATTGTACACAGGGACCTGAAGGCTGAGAACC
TCTTGCTGGATGCCGAGGCCAACATCAAGATTGCTGACTTTGGCTTCAGCAACGAGTTCACGCTGGGATCGAAGCTGGACACGTTCTGCG
GGAGCCCCCCATATGCCGCCCCGGAGCTGTTTCAGGGCAAGAAGTACGACGGGCCGGAGGTGGACATCTGGAGCCTGGGAGTCATCCTGT
ACACCCTCGTCAGCGGCTCCCTGCCCTTCGACGGGCACAACCTCAAGGAGCTGCGGGAGCGAGTACTCAGAGGGAAGTACCGGGTCCCTT
TCTACATGTCAACAGACTGTGAGAGCATCCTGCGGAGATTTTTGGTGCTGAACCCAGCTAAACGCTGTACTCTCGAGCAAATCATGAAAG
ACAAATGGATCAACATCGGCTATGAGGGTGAGGAGTTGAAGCCATACACAGAGCCCGAGGAGGACTTCGGGGACACCAAGAGAATTGAGG
TGATGGTGGGTATGGGCTACACACGGGAAGAAATCAAAGAGTCCTTGACCAGCCAGAAGTACAACGAAGTGACCGCCACCTACCTCCTGC
TGGGCAGGAAGACTGAGGAGGGTGGGGACCGGGGCGCCCCAGGGCTGGCCCTGGCACGGGTGCGGGCGCCCAGCGACACCACCAACGGAA
CAAGTTCCAGCAAAGGCACCAGCCACAGCAAAGGGCAGCGGAGTTCCTCTTCCACCTACCACCGCCAGCGCAGGCATAGCGATTTCTGTG
GCCCATCCCCTGCACCCCTGCACCCCAAACGCAGCCCGACGAGCACGGGGGAGGCGGAGCTGAAGGAGGAGCGGCTGCCAGGCCGGAAGG
CGAGCTGCAGCACCGCGGGGAGTGGGAGTCGAGGGCTGCCCCCCTCCAGCCCCATGGTCAGCAGCGCCCACAACCCCAACAAGGCAGAGA
TCCCAGAGCGGCGGAAGGACAGCACGAGCACCCCCAACAACCTCCCTCCTAGCATGATGACCCGCAGAAACACCTACGTTTGCACAGAAC
GCCCGGGGGCTGAGCGCCCGTCACTGTTGCCAAATGGGAAAGAAAACAGCTCAGGCACCCCACGGGTGCCCCCTGCCTCCCCCTCCAGTC
ACAGCCTGGCACCCCCATCAGGGGAGCGGAGCCGCCTGGCACGTGGTTCCACCATCCGCAGCACCTTCCATGGTGGCCAGGTCCGGGACC
GGCGGGCAGGGGGTGGGGGTGGTGGGGGTGTGCAGAATGGGCCCCCTGCCTCTCCCACACTGGCCCATGAGGCTGCACCCCTGCCCGCCG
GGCGGCCCCGCCCCACCACCAACCTCTTCACCAAGCTGACCTCCAAACTGACCCGAAGGGTTACCCTCGATCCCTCTAAACGGCAGAACT
CTAACCGCTGTGTTTCGGGCGCCTCTCTGCCCCAGGGATCCAAGATCAGGTCGCAGACGAACCTGAGAGAATCGGGGGACCTGAGGTCAC
AAGTTGCCATCTACCTTGGGATCAAACGGAAACCGCCCCCCGGCTGCTCCGATTCCCCTGGAGTGTGAAGCTGACCAGCTCGCGCCCTCC
TGAGGCCCTGATGGCAGCTCTGCGCCAGGCCACAGCAGCCGCCCGCTGCCGCTGCCGCCAGCCACAGCCGTTCCTGCTGGCCTGCCTGCA
CGGGGGTGCGGGCGGGCCCGAGCCCCTGTCCCACTTCGAAGTGGAGGTCTGCCAGCTGCCCCGGCCAGGCTTGCGGGGAGTTCTCTTCCG
CCGTGTGGCGGGCACCGCCCTGGCCTTCCGCACCCTCGTCACCCGCATCTCCAACGACCTCGAGCTCTGAGCCACCACGGTCCCAGGGCC
CTTACTCTTCCTCTCCCTTGTCGCCTTCACTTCTACAGGAGGGGAAGGGGCCAGGGAGGGGATTCTCCCTTTATCATCACCTCAGTTTCC
CTGAATTATATTTGGGGGCAAAGATTGTCCCCTCTGCTGTTCTCTGGGGCCGCTCAGCACAGAAGAAGGATGAGGGGGCTCAGCGGGGGG
AGCTGGCACCTTCCTGGAGCCTCCAGCCAGTCCTGTCCTCCCTCGCCCTACCAAGAGGGCACCTGAGGAGACTTTGGGGACAGGGCAGGG
GCAGGGAGGGAAACTGAGGAAATCTTCCATTCCTCCCAACAGCTCAAAATTAGGCCTTGGGCAGGGGCAGGGAGAGCTGCTGAGCCTAAA
GACTGGAGAATCTGGGGGACTGGGAGTGGGGGTCAGAGAGGCAGATTCCTTCCCCTCCCGTCCCCTCACGCTCAAACCCCCACTTCCTGC
CCCAGGCTGGCGCGGGGCACTTTGTACAAATCCTTGTAAATACCCCACACCCTCCCCTCTGCAAAGGTCTCTTGAGGAGCTGCCGCTGTC
ACCTACGGTTTTTAAGTTATTACACCCCGACCCTCCTCCTGTCAGCCCCCTCACCTGCAGCCTGTTGCCCAATAAATTTAAGAGAGTCCC
CCCCTCCCCAATGCTGACCCTAGGATTTTCCTTCCCTGCCCTCACCTGCAAATGAGTTAAAGAAGAGGCGTGGGAATCCAGGCAGTGGTT
TTTCCTTTCGGAGCCTCGGTTTTCTCATCTGCAGAATGGGAGCGGTGGGGGTGGGAAGGTAAGGATGGTCGTGGAAGAAGGCAGGATGGA
ACTCGGCCTCATCCCCGAGGCCCCAGTTCCTATATCGGGCCCCCCATTCATCCACTCACACTCCCAGCCACCATGTTACACTGGACTCTA
AGCCACTTCTTACTCCAGTAGTAAATTTATTCAATAAACAATCATTGACCCATGCCTACTCCATGCCAGGCCCAGTGCTGGACACAGAGA
CATGAAGCTCTGTCTGTGGGAGACAGGGATTCTGACACAGACACCGGACAAACCATTGTCTTGGGGAGCCCAGAAGAGAAAGTGGGCAGG
GTGGGGTCATTGGGGAAGATGCTCTAGAGGAATTAATGCTGGAATGGGGTGTTGAAGGATGAGTAGGAGTTAGTTAGGCATTGAGTTTGC
CCTGGGCAAAAGCCCAGAAGTGGGAGTATGTGGTATATCTTCAGAGAACTGGGTAATTTCAGTGTGGCTGCTGTGTTGGGCATGGATGGA
GAATCAGCAAGAGAAATGCTGTATTAGGACTAATAATCCATCTACGCTGCTTAAGCAAAAAGGTATTTGTTGGTTTATGTTACTTAATAG
TCCAGGGGCACCTGGCTTCAGGTAGGTTTGATCCAGGCATCAGGCCATTGCATCTATTTTTTCAGTGTAAGTTGAATTCTAGTAATTTTT
ATCAAGTAAGGGCTCCTTTCCTGGTGGCACAGATGACTTCAGCAGTTAGAAGTTTCTATCCCTCCAGCTTTCTGCAGCAGAAAGACCCTC
ATTGTCAGTTTCCCAGCAAAAGTCCCAGGGCAGACTCTCATTGGCCCAAATGGGCCATGTGATTTTCTCTAAACCAATCACTGTGACTCT
AGAGTGGCCAGACTCAGAGCTGCACTTAGTAGGGGTTCCTCAAAGGAAGGTCAAGTGTCATGAGCAGGAGAAAAGGCATGGGAGCTGGAC
AGATTATAGTGGTTGAAGTCTGTGCAGTACAGAAGGGCGGAGCTTATTCACACAGCACCTTTGGGGCCAAAATGAATAAGCTGGACTTTC
TCCCCATGGCACTGGGGAACCATGGAAGTTCAGGGAACTTCAGGGAAGAGGCTTGGTCAATTCCTGAGAGCATCCTCTGTGCTGGGGACA
CAGTGGTAATCAAGACAGCCCCAACACTGCCCTCATAGAGCTCACAGTCCAATGGAGGAGGCAGATGTGTCCTCAGGCAGCGACTGGGCA
GGGCTGGTATAGGGGAGTCCAGAGGTGATGCCTGCCTCAGCCAGGGAGGGCTTCCTGGAGGAGAAGGAGCCAGCTAGACATGGATAGGAG
TGCGTTTTAGGCACAGCAAATGGCACATACAAGGGCCAGGGAGCAAGAGAGAGGACAGGTCCTCAACAAATGGCATGTGACTTTGTAAGT
GTAGAATTGCTGTGAGGTATGGGGCTAGGGGCGTCAGTAGGGCCTTGAAGGTTATGGACAGGGGCCTGGGCTTTCTTCCAAGGGCACTGG
GGGAGCCATGGCAAGGTTGTAGGTAGGGTAGAGATGGGCGGGTTTGTGCTATGTGCAGGGTGGAAGGGAGGGAAGTTGACAGGTCAGAAG
ATCAGGAAAGAGGTCGGGGCTGGACAGATGGGGAGAGCGCAGATAGATTTAAGAGAGTCCTGTGAGGCAAAGTGGGCAGGACCTGGTAAC
AGGTGTCTGGACTGTGGCTTTGGCTGGCTCAGAAGGTCCCCACTGGCGTGTGTGGTCTATGTAGCCTCTGGGTGTGGAGCTGGGATCTTC

>65926_65926_2_PLAUR-MARK4_PLAUR_chr19_44174218_ENST00000221264_MARK4_chr19_45762247_ENST00000300843_length(amino acids)=668AA_BP=
MGSGRSSDKGPSWSSRSLGARCRNSIASCPEEQPHVGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIM
KGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADF
GFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRF
LVLNPAKRCTLEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKESLTSQKYNEVTATYLLLGRKTEEGGDRGAP
GLALARVRAPSDTTNGTSSSKGTSHSKGQRSSSSTYHRQRRHSDFCGPSPAPLHPKRSPTSTGEAELKEERLPGRKASCSTAGSGSRGLP
PSSPMVSSAHNPNKAEIPERRKDSTSTPNNLPPSMMTRRNTYVCTERPGAERPSLLPNGKENSSGTPRVPPASPSSHSLAPPSGERSRLA
RGSTIRSTFHGGQVRDRRAGGGGGGGVQNGPPASPTLAHEAAPLPAGRPRPTTNLFTKLTSKLTRRVTLDPSKRQNSNRCVSGASLPQGS

--------------------------------------------------------------
>65926_65926_3_PLAUR-MARK4_PLAUR_chr19_44174218_ENST00000339082_MARK4_chr19_45762247_ENST00000262891_length(transcript)=3292nt_BP=101nt
AGAGAAGACGTGCAGGGACCCCGCGCACAGGAGCTGCCCTCGCGACATGGGTCACCCGCCGCTGCTGCCGCTGCTGCTGCTGCTCCACAC
CTGCGTCCCAGCATGGCACCTTGGGCAGTGGCCGCTCCTCGGACAAAGGCCCGTCCTGGTCCAGCCGCTCACTGGGTGCCCGTTGCCGGA
ACTCCATCGCCTCCTGTCCCGAGGAGCAGCCCCACGTGGGCAACTACCGCCTGCTGAGGACCATTGGGAAGGGCAACTTTGCCAAAGTCA
AGCTGGCTCGGCACATCCTCACTGGTCGGGAGGTTGCCATCAAGATTATCGACAAAACCCAGCTGAATCCCAGCAGCCTGCAGAAGCTGT
TCCGAGAAGTCCGCATCATGAAGGGCCTAAACCACCCCAACATCGTGAAGCTCTTTGAGGTGATTGAGACTGAGAAGACGCTGTACCTGG
TGATGGAGTACGCAAGTGCTGGAGAAGTGTTTGACTACCTCGTGTCGCATGGCCGCATGAAGGAGAAGGAAGCTCGAGCCAAGTTCCGAC
AGATTGTTTCGGCTGTGCACTATTGTCACCAGAAAAATATTGTACACAGGGACCTGAAGGCTGAGAACCTCTTGCTGGATGCCGAGGCCA
ACATCAAGATTGCTGACTTTGGCTTCAGCAACGAGTTCACGCTGGGATCGAAGCTGGACACGTTCTGCGGGAGCCCCCCATATGCCGCCC
CGGAGCTGTTTCAGGGCAAGAAGTACGACGGGCCGGAGGTGGACATCTGGAGCCTGGGAGTCATCCTGTACACCCTCGTCAGCGGCTCCC
TGCCCTTCGACGGGCACAACCTCAAGGAGCTGCGGGAGCGAGTACTCAGAGGGAAGTACCGGGTCCCTTTCTACATGTCAACAGACTGTG
AGAGCATCCTGCGGAGATTTTTGGTGCTGAACCCAGCTAAACGCTGTACTCTCGAGCAAATCATGAAAGACAAATGGATCAACATCGGCT
ATGAGGGTGAGGAGTTGAAGCCATACACAGAGCCCGAGGAGGACTTCGGGGACACCAAGAGAATTGAGGTGATGGTGGGTATGGGCTACA
CACGGGAAGAAATCAAAGAGTCCTTGACCAGCCAGAAGTACAACGAAGTGACCGCCACCTACCTCCTGCTGGGCAGGAAGACTGAGGAGG
GTGGGGACCGGGGCGCCCCAGGGCTGGCCCTGGCACGGGTGCGGGCGCCCAGCGACACCACCAACGGAACAAGTTCCAGCAAAGGCACCA
GCCACAGCAAAGGGCAGCGGAGTTCCTCTTCCACCTACCACCGCCAGCGCAGGCATAGCGATTTCTGTGGCCCATCCCCTGCACCCCTGC
ACCCCAAACGCAGCCCGACGAGCACGGGGGAGGCGGAGCTGAAGGAGGAGCGGCTGCCAGGCCGGAAGGCGAGCTGCAGCACCGCGGGGA
GTGGGAGTCGAGGGCTGCCCCCCTCCAGCCCCATGGTCAGCAGCGCCCACAACCCCAACAAGGCAGAGATCCCAGAGCGGCGGAAGGACA
GCACGAGCACCCCCAACAACCTCCCTCCTAGCATGATGACCCGCAGAAACACCTACGTTTGCACAGAACGCCCGGGGGCTGAGCGCCCGT
CACTGTTGCCAAATGGGAAAGAAAACAGCTCAGGCACCCCACGGGTGCCCCCTGCCTCCCCCTCCAGTCACAGCCTGGCACCCCCATCAG
GGGAGCGGAGCCGCCTGGCACGTGGTTCCACCATCCGCAGCACCTTCCATGGTGGCCAGGTCCGGGACCGGCGGGCAGGGGGTGGGGGTG
GTGGGGGTGTGCAGAATGGGCCCCCTGCCTCTCCCACACTGGCCCATGAGGCTGCACCCCTGCCCGCCGGGCGGCCCCGCCCCACCACCA
ACCTCTTCACCAAGCTGACCTCCAAACTGACCCGAAGGGTCGCAGACGAACCTGAGAGAATCGGGGGACCTGAGGTCACAAGTTGCCATC
TACCTTGGGATCAAACGGAAACCGCCCCCCGGCTGCTCCGATTCCCCTGGAGTGTGAAGCTGACCAGCTCGCGCCCTCCTGAGGCCCTGA
TGGCAGCTCTGCGCCAGGCCACAGCAGCCGCCCGCTGCCGCTGCCGCCAGCCACAGCCGTTCCTGCTGGCCTGCCTGCACGGGGGTGCGG
GCGGGCCCGAGCCCCTGTCCCACTTCGAAGTGGAGGTCTGCCAGCTGCCCCGGCCAGGCTTGCGGGGAGTTCTCTTCCGCCGTGTGGCGG
GCACCGCCCTGGCCTTCCGCACCCTCGTCACCCGCATCTCCAACGACCTCGAGCTCTGAGCCACCACGGTCCCAGGGCCCTTACTCTTCC
TCTCCCTTGTCGCCTTCACTTCTACAGGAGGGGAAGGGGCCAGGGAGGGGATTCTCCCTTTATCATCACCTCAGTTTCCCTGAATTATAT
TTGGGGGCAAAGATTGTCCCCTCTGCTGTTCTCTGGGGCCGCTCAGCACAGAAGAAGGATGAGGGGGCTCAGCGGGGGGAGCTGGCACCT
TCCTGGAGCCTCCAGCCAGTCCTGTCCTCCCTCGCCCTACCAAGAGGGCACCTGAGGAGACTTTGGGGACAGGGCAGGGGCAGGGAGGGA
AACTGAGGAAATCTTCCATTCCTCCCAACAGCTCAAAATTAGGCCTTGGGCAGGGGCAGGGAGAGCTGCTGAGCCTAAAGACTGGAGAAT
CTGGGGGACTGGGAGTGGGGGTCAGAGAGGCAGATTCCTTCCCCTCCCGTCCCCTCACGCTCAAACCCCCACTTCCTGCCCCAGGCTGGC
GCGGGGCACTTTGTACAAATCCTTGTAAATACCCCACACCCTCCCCTCTGCAAAGGTCTCTTGAGGAGCTGCCGCTGTCACCTACGGTTT
TTAAGTTATTACACCCCGACCCTCCTCCTGTCAGCCCCCTCACCTGCAGCCTGTTGCCCAATAAATTTAAGAGAGTCCCCCCCTCCCCAA
TGCTGACCCTAGGATTTTCCTTCCCTGCCCTCACCTGCAAATGAGTTAAAGAAGAGGCGTGGGAATCCAGGCAGTGGTTTTTCCTTTCGG
AGCCTCGGTTTTCTCATCTGCAGAATGGGAGCGGTGGGGGTGGGAAGGTAAGGATGGTCGTGGAAGAAGGCAGGATGGAACTCGGCCTCA
TCCCCGAGGCCCCAGTTCCTATATCGGGCCCCCCATTCATCCACTCACACTCCCAGCCACCATGTTACACTGGACTCTAAGCCACTTCTT

>65926_65926_3_PLAUR-MARK4_PLAUR_chr19_44174218_ENST00000339082_MARK4_chr19_45762247_ENST00000262891_length(amino acids)=732AA_BP=
MGSGRSSDKGPSWSSRSLGARCRNSIASCPEEQPHVGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIM
KGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADF
GFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRF
LVLNPAKRCTLEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKESLTSQKYNEVTATYLLLGRKTEEGGDRGAP
GLALARVRAPSDTTNGTSSSKGTSHSKGQRSSSSTYHRQRRHSDFCGPSPAPLHPKRSPTSTGEAELKEERLPGRKASCSTAGSGSRGLP
PSSPMVSSAHNPNKAEIPERRKDSTSTPNNLPPSMMTRRNTYVCTERPGAERPSLLPNGKENSSGTPRVPPASPSSHSLAPPSGERSRLA
RGSTIRSTFHGGQVRDRRAGGGGGGGVQNGPPASPTLAHEAAPLPAGRPRPTTNLFTKLTSKLTRRVADEPERIGGPEVTSCHLPWDQTE
TAPRLLRFPWSVKLTSSRPPEALMAALRQATAAARCRCRQPQPFLLACLHGGAGGPEPLSHFEVEVCQLPRPGLRGVLFRRVAGTALAFR

--------------------------------------------------------------
>65926_65926_4_PLAUR-MARK4_PLAUR_chr19_44174218_ENST00000339082_MARK4_chr19_45762247_ENST00000300843_length(transcript)=4962nt_BP=101nt
AGAGAAGACGTGCAGGGACCCCGCGCACAGGAGCTGCCCTCGCGACATGGGTCACCCGCCGCTGCTGCCGCTGCTGCTGCTGCTCCACAC
CTGCGTCCCAGCATGGCACCTTGGGCAGTGGCCGCTCCTCGGACAAAGGCCCGTCCTGGTCCAGCCGCTCACTGGGTGCCCGTTGCCGGA
ACTCCATCGCCTCCTGTCCCGAGGAGCAGCCCCACGTGGGCAACTACCGCCTGCTGAGGACCATTGGGAAGGGCAACTTTGCCAAAGTCA
AGCTGGCTCGGCACATCCTCACTGGTCGGGAGGTTGCCATCAAGATTATCGACAAAACCCAGCTGAATCCCAGCAGCCTGCAGAAGCTGT
TCCGAGAAGTCCGCATCATGAAGGGCCTAAACCACCCCAACATCGTGAAGCTCTTTGAGGTGATTGAGACTGAGAAGACGCTGTACCTGG
TGATGGAGTACGCAAGTGCTGGAGAAGTGTTTGACTACCTCGTGTCGCATGGCCGCATGAAGGAGAAGGAAGCTCGAGCCAAGTTCCGAC
AGATTGTTTCGGCTGTGCACTATTGTCACCAGAAAAATATTGTACACAGGGACCTGAAGGCTGAGAACCTCTTGCTGGATGCCGAGGCCA
ACATCAAGATTGCTGACTTTGGCTTCAGCAACGAGTTCACGCTGGGATCGAAGCTGGACACGTTCTGCGGGAGCCCCCCATATGCCGCCC
CGGAGCTGTTTCAGGGCAAGAAGTACGACGGGCCGGAGGTGGACATCTGGAGCCTGGGAGTCATCCTGTACACCCTCGTCAGCGGCTCCC
TGCCCTTCGACGGGCACAACCTCAAGGAGCTGCGGGAGCGAGTACTCAGAGGGAAGTACCGGGTCCCTTTCTACATGTCAACAGACTGTG
AGAGCATCCTGCGGAGATTTTTGGTGCTGAACCCAGCTAAACGCTGTACTCTCGAGCAAATCATGAAAGACAAATGGATCAACATCGGCT
ATGAGGGTGAGGAGTTGAAGCCATACACAGAGCCCGAGGAGGACTTCGGGGACACCAAGAGAATTGAGGTGATGGTGGGTATGGGCTACA
CACGGGAAGAAATCAAAGAGTCCTTGACCAGCCAGAAGTACAACGAAGTGACCGCCACCTACCTCCTGCTGGGCAGGAAGACTGAGGAGG
GTGGGGACCGGGGCGCCCCAGGGCTGGCCCTGGCACGGGTGCGGGCGCCCAGCGACACCACCAACGGAACAAGTTCCAGCAAAGGCACCA
GCCACAGCAAAGGGCAGCGGAGTTCCTCTTCCACCTACCACCGCCAGCGCAGGCATAGCGATTTCTGTGGCCCATCCCCTGCACCCCTGC
ACCCCAAACGCAGCCCGACGAGCACGGGGGAGGCGGAGCTGAAGGAGGAGCGGCTGCCAGGCCGGAAGGCGAGCTGCAGCACCGCGGGGA
GTGGGAGTCGAGGGCTGCCCCCCTCCAGCCCCATGGTCAGCAGCGCCCACAACCCCAACAAGGCAGAGATCCCAGAGCGGCGGAAGGACA
GCACGAGCACCCCCAACAACCTCCCTCCTAGCATGATGACCCGCAGAAACACCTACGTTTGCACAGAACGCCCGGGGGCTGAGCGCCCGT
CACTGTTGCCAAATGGGAAAGAAAACAGCTCAGGCACCCCACGGGTGCCCCCTGCCTCCCCCTCCAGTCACAGCCTGGCACCCCCATCAG
GGGAGCGGAGCCGCCTGGCACGTGGTTCCACCATCCGCAGCACCTTCCATGGTGGCCAGGTCCGGGACCGGCGGGCAGGGGGTGGGGGTG
GTGGGGGTGTGCAGAATGGGCCCCCTGCCTCTCCCACACTGGCCCATGAGGCTGCACCCCTGCCCGCCGGGCGGCCCCGCCCCACCACCA
ACCTCTTCACCAAGCTGACCTCCAAACTGACCCGAAGGGTTACCCTCGATCCCTCTAAACGGCAGAACTCTAACCGCTGTGTTTCGGGCG
CCTCTCTGCCCCAGGGATCCAAGATCAGGTCGCAGACGAACCTGAGAGAATCGGGGGACCTGAGGTCACAAGTTGCCATCTACCTTGGGA
TCAAACGGAAACCGCCCCCCGGCTGCTCCGATTCCCCTGGAGTGTGAAGCTGACCAGCTCGCGCCCTCCTGAGGCCCTGATGGCAGCTCT
GCGCCAGGCCACAGCAGCCGCCCGCTGCCGCTGCCGCCAGCCACAGCCGTTCCTGCTGGCCTGCCTGCACGGGGGTGCGGGCGGGCCCGA
GCCCCTGTCCCACTTCGAAGTGGAGGTCTGCCAGCTGCCCCGGCCAGGCTTGCGGGGAGTTCTCTTCCGCCGTGTGGCGGGCACCGCCCT
GGCCTTCCGCACCCTCGTCACCCGCATCTCCAACGACCTCGAGCTCTGAGCCACCACGGTCCCAGGGCCCTTACTCTTCCTCTCCCTTGT
CGCCTTCACTTCTACAGGAGGGGAAGGGGCCAGGGAGGGGATTCTCCCTTTATCATCACCTCAGTTTCCCTGAATTATATTTGGGGGCAA
AGATTGTCCCCTCTGCTGTTCTCTGGGGCCGCTCAGCACAGAAGAAGGATGAGGGGGCTCAGCGGGGGGAGCTGGCACCTTCCTGGAGCC
TCCAGCCAGTCCTGTCCTCCCTCGCCCTACCAAGAGGGCACCTGAGGAGACTTTGGGGACAGGGCAGGGGCAGGGAGGGAAACTGAGGAA
ATCTTCCATTCCTCCCAACAGCTCAAAATTAGGCCTTGGGCAGGGGCAGGGAGAGCTGCTGAGCCTAAAGACTGGAGAATCTGGGGGACT
GGGAGTGGGGGTCAGAGAGGCAGATTCCTTCCCCTCCCGTCCCCTCACGCTCAAACCCCCACTTCCTGCCCCAGGCTGGCGCGGGGCACT
TTGTACAAATCCTTGTAAATACCCCACACCCTCCCCTCTGCAAAGGTCTCTTGAGGAGCTGCCGCTGTCACCTACGGTTTTTAAGTTATT
ACACCCCGACCCTCCTCCTGTCAGCCCCCTCACCTGCAGCCTGTTGCCCAATAAATTTAAGAGAGTCCCCCCCTCCCCAATGCTGACCCT
AGGATTTTCCTTCCCTGCCCTCACCTGCAAATGAGTTAAAGAAGAGGCGTGGGAATCCAGGCAGTGGTTTTTCCTTTCGGAGCCTCGGTT
TTCTCATCTGCAGAATGGGAGCGGTGGGGGTGGGAAGGTAAGGATGGTCGTGGAAGAAGGCAGGATGGAACTCGGCCTCATCCCCGAGGC
CCCAGTTCCTATATCGGGCCCCCCATTCATCCACTCACACTCCCAGCCACCATGTTACACTGGACTCTAAGCCACTTCTTACTCCAGTAG
TAAATTTATTCAATAAACAATCATTGACCCATGCCTACTCCATGCCAGGCCCAGTGCTGGACACAGAGACATGAAGCTCTGTCTGTGGGA
GACAGGGATTCTGACACAGACACCGGACAAACCATTGTCTTGGGGAGCCCAGAAGAGAAAGTGGGCAGGGTGGGGTCATTGGGGAAGATG
CTCTAGAGGAATTAATGCTGGAATGGGGTGTTGAAGGATGAGTAGGAGTTAGTTAGGCATTGAGTTTGCCCTGGGCAAAAGCCCAGAAGT
GGGAGTATGTGGTATATCTTCAGAGAACTGGGTAATTTCAGTGTGGCTGCTGTGTTGGGCATGGATGGAGAATCAGCAAGAGAAATGCTG
TATTAGGACTAATAATCCATCTACGCTGCTTAAGCAAAAAGGTATTTGTTGGTTTATGTTACTTAATAGTCCAGGGGCACCTGGCTTCAG
GTAGGTTTGATCCAGGCATCAGGCCATTGCATCTATTTTTTCAGTGTAAGTTGAATTCTAGTAATTTTTATCAAGTAAGGGCTCCTTTCC
TGGTGGCACAGATGACTTCAGCAGTTAGAAGTTTCTATCCCTCCAGCTTTCTGCAGCAGAAAGACCCTCATTGTCAGTTTCCCAGCAAAA
GTCCCAGGGCAGACTCTCATTGGCCCAAATGGGCCATGTGATTTTCTCTAAACCAATCACTGTGACTCTAGAGTGGCCAGACTCAGAGCT
GCACTTAGTAGGGGTTCCTCAAAGGAAGGTCAAGTGTCATGAGCAGGAGAAAAGGCATGGGAGCTGGACAGATTATAGTGGTTGAAGTCT
GTGCAGTACAGAAGGGCGGAGCTTATTCACACAGCACCTTTGGGGCCAAAATGAATAAGCTGGACTTTCTCCCCATGGCACTGGGGAACC
ATGGAAGTTCAGGGAACTTCAGGGAAGAGGCTTGGTCAATTCCTGAGAGCATCCTCTGTGCTGGGGACACAGTGGTAATCAAGACAGCCC
CAACACTGCCCTCATAGAGCTCACAGTCCAATGGAGGAGGCAGATGTGTCCTCAGGCAGCGACTGGGCAGGGCTGGTATAGGGGAGTCCA
GAGGTGATGCCTGCCTCAGCCAGGGAGGGCTTCCTGGAGGAGAAGGAGCCAGCTAGACATGGATAGGAGTGCGTTTTAGGCACAGCAAAT
GGCACATACAAGGGCCAGGGAGCAAGAGAGAGGACAGGTCCTCAACAAATGGCATGTGACTTTGTAAGTGTAGAATTGCTGTGAGGTATG
GGGCTAGGGGCGTCAGTAGGGCCTTGAAGGTTATGGACAGGGGCCTGGGCTTTCTTCCAAGGGCACTGGGGGAGCCATGGCAAGGTTGTA
GGTAGGGTAGAGATGGGCGGGTTTGTGCTATGTGCAGGGTGGAAGGGAGGGAAGTTGACAGGTCAGAAGATCAGGAAAGAGGTCGGGGCT
GGACAGATGGGGAGAGCGCAGATAGATTTAAGAGAGTCCTGTGAGGCAAAGTGGGCAGGACCTGGTAACAGGTGTCTGGACTGTGGCTTT
GGCTGGCTCAGAAGGTCCCCACTGGCGTGTGTGGTCTATGTAGCCTCTGGGTGTGGAGCTGGGATCTTCAACTGGGGACAGTACAGTAAA

>65926_65926_4_PLAUR-MARK4_PLAUR_chr19_44174218_ENST00000339082_MARK4_chr19_45762247_ENST00000300843_length(amino acids)=668AA_BP=
MGSGRSSDKGPSWSSRSLGARCRNSIASCPEEQPHVGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIM
KGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADF
GFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRF
LVLNPAKRCTLEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKESLTSQKYNEVTATYLLLGRKTEEGGDRGAP
GLALARVRAPSDTTNGTSSSKGTSHSKGQRSSSSTYHRQRRHSDFCGPSPAPLHPKRSPTSTGEAELKEERLPGRKASCSTAGSGSRGLP
PSSPMVSSAHNPNKAEIPERRKDSTSTPNNLPPSMMTRRNTYVCTERPGAERPSLLPNGKENSSGTPRVPPASPSSHSLAPPSGERSRLA
RGSTIRSTFHGGQVRDRRAGGGGGGGVQNGPPASPTLAHEAAPLPAGRPRPTTNLFTKLTSKLTRRVTLDPSKRQNSNRCVSGASLPQGS

--------------------------------------------------------------
>65926_65926_5_PLAUR-MARK4_PLAUR_chr19_44174218_ENST00000340093_MARK4_chr19_45762247_ENST00000262891_length(transcript)=3476nt_BP=285nt
CAGGGCCGAGCCAGCCCCTTCACCACCAGCCGGCCGCGCCCCGGGAAGGGAAGTTTGTGGCGGAGGAGGTTCGTACGGGAGGAGGGGGAG
GCGCCCACGCATCTGGGGCTGACTCGCTCTTTCGCAAAACGTCTGGGAGGAGTCCCTGGGGCCACAAAACTGCCTCCTTCCTGAGGCCAG
AAGGAGAGAAGACGTGCAGGGACCCCGCGCACAGGAGCTGCCCTCGCGACATGGGTCACCCGCCGCTGCTGCCGCTGCTGCTGCTGCTCC
ACACCTGCGTCCCAGCATGGCACCTTGGGCAGTGGCCGCTCCTCGGACAAAGGCCCGTCCTGGTCCAGCCGCTCACTGGGTGCCCGTTGC
CGGAACTCCATCGCCTCCTGTCCCGAGGAGCAGCCCCACGTGGGCAACTACCGCCTGCTGAGGACCATTGGGAAGGGCAACTTTGCCAAA
GTCAAGCTGGCTCGGCACATCCTCACTGGTCGGGAGGTTGCCATCAAGATTATCGACAAAACCCAGCTGAATCCCAGCAGCCTGCAGAAG
CTGTTCCGAGAAGTCCGCATCATGAAGGGCCTAAACCACCCCAACATCGTGAAGCTCTTTGAGGTGATTGAGACTGAGAAGACGCTGTAC
CTGGTGATGGAGTACGCAAGTGCTGGAGAAGTGTTTGACTACCTCGTGTCGCATGGCCGCATGAAGGAGAAGGAAGCTCGAGCCAAGTTC
CGACAGATTGTTTCGGCTGTGCACTATTGTCACCAGAAAAATATTGTACACAGGGACCTGAAGGCTGAGAACCTCTTGCTGGATGCCGAG
GCCAACATCAAGATTGCTGACTTTGGCTTCAGCAACGAGTTCACGCTGGGATCGAAGCTGGACACGTTCTGCGGGAGCCCCCCATATGCC
GCCCCGGAGCTGTTTCAGGGCAAGAAGTACGACGGGCCGGAGGTGGACATCTGGAGCCTGGGAGTCATCCTGTACACCCTCGTCAGCGGC
TCCCTGCCCTTCGACGGGCACAACCTCAAGGAGCTGCGGGAGCGAGTACTCAGAGGGAAGTACCGGGTCCCTTTCTACATGTCAACAGAC
TGTGAGAGCATCCTGCGGAGATTTTTGGTGCTGAACCCAGCTAAACGCTGTACTCTCGAGCAAATCATGAAAGACAAATGGATCAACATC
GGCTATGAGGGTGAGGAGTTGAAGCCATACACAGAGCCCGAGGAGGACTTCGGGGACACCAAGAGAATTGAGGTGATGGTGGGTATGGGC
TACACACGGGAAGAAATCAAAGAGTCCTTGACCAGCCAGAAGTACAACGAAGTGACCGCCACCTACCTCCTGCTGGGCAGGAAGACTGAG
GAGGGTGGGGACCGGGGCGCCCCAGGGCTGGCCCTGGCACGGGTGCGGGCGCCCAGCGACACCACCAACGGAACAAGTTCCAGCAAAGGC
ACCAGCCACAGCAAAGGGCAGCGGAGTTCCTCTTCCACCTACCACCGCCAGCGCAGGCATAGCGATTTCTGTGGCCCATCCCCTGCACCC
CTGCACCCCAAACGCAGCCCGACGAGCACGGGGGAGGCGGAGCTGAAGGAGGAGCGGCTGCCAGGCCGGAAGGCGAGCTGCAGCACCGCG
GGGAGTGGGAGTCGAGGGCTGCCCCCCTCCAGCCCCATGGTCAGCAGCGCCCACAACCCCAACAAGGCAGAGATCCCAGAGCGGCGGAAG
GACAGCACGAGCACCCCCAACAACCTCCCTCCTAGCATGATGACCCGCAGAAACACCTACGTTTGCACAGAACGCCCGGGGGCTGAGCGC
CCGTCACTGTTGCCAAATGGGAAAGAAAACAGCTCAGGCACCCCACGGGTGCCCCCTGCCTCCCCCTCCAGTCACAGCCTGGCACCCCCA
TCAGGGGAGCGGAGCCGCCTGGCACGTGGTTCCACCATCCGCAGCACCTTCCATGGTGGCCAGGTCCGGGACCGGCGGGCAGGGGGTGGG
GGTGGTGGGGGTGTGCAGAATGGGCCCCCTGCCTCTCCCACACTGGCCCATGAGGCTGCACCCCTGCCCGCCGGGCGGCCCCGCCCCACC
ACCAACCTCTTCACCAAGCTGACCTCCAAACTGACCCGAAGGGTCGCAGACGAACCTGAGAGAATCGGGGGACCTGAGGTCACAAGTTGC
CATCTACCTTGGGATCAAACGGAAACCGCCCCCCGGCTGCTCCGATTCCCCTGGAGTGTGAAGCTGACCAGCTCGCGCCCTCCTGAGGCC
CTGATGGCAGCTCTGCGCCAGGCCACAGCAGCCGCCCGCTGCCGCTGCCGCCAGCCACAGCCGTTCCTGCTGGCCTGCCTGCACGGGGGT
GCGGGCGGGCCCGAGCCCCTGTCCCACTTCGAAGTGGAGGTCTGCCAGCTGCCCCGGCCAGGCTTGCGGGGAGTTCTCTTCCGCCGTGTG
GCGGGCACCGCCCTGGCCTTCCGCACCCTCGTCACCCGCATCTCCAACGACCTCGAGCTCTGAGCCACCACGGTCCCAGGGCCCTTACTC
TTCCTCTCCCTTGTCGCCTTCACTTCTACAGGAGGGGAAGGGGCCAGGGAGGGGATTCTCCCTTTATCATCACCTCAGTTTCCCTGAATT
ATATTTGGGGGCAAAGATTGTCCCCTCTGCTGTTCTCTGGGGCCGCTCAGCACAGAAGAAGGATGAGGGGGCTCAGCGGGGGGAGCTGGC
ACCTTCCTGGAGCCTCCAGCCAGTCCTGTCCTCCCTCGCCCTACCAAGAGGGCACCTGAGGAGACTTTGGGGACAGGGCAGGGGCAGGGA
GGGAAACTGAGGAAATCTTCCATTCCTCCCAACAGCTCAAAATTAGGCCTTGGGCAGGGGCAGGGAGAGCTGCTGAGCCTAAAGACTGGA
GAATCTGGGGGACTGGGAGTGGGGGTCAGAGAGGCAGATTCCTTCCCCTCCCGTCCCCTCACGCTCAAACCCCCACTTCCTGCCCCAGGC
TGGCGCGGGGCACTTTGTACAAATCCTTGTAAATACCCCACACCCTCCCCTCTGCAAAGGTCTCTTGAGGAGCTGCCGCTGTCACCTACG
GTTTTTAAGTTATTACACCCCGACCCTCCTCCTGTCAGCCCCCTCACCTGCAGCCTGTTGCCCAATAAATTTAAGAGAGTCCCCCCCTCC
CCAATGCTGACCCTAGGATTTTCCTTCCCTGCCCTCACCTGCAAATGAGTTAAAGAAGAGGCGTGGGAATCCAGGCAGTGGTTTTTCCTT
TCGGAGCCTCGGTTTTCTCATCTGCAGAATGGGAGCGGTGGGGGTGGGAAGGTAAGGATGGTCGTGGAAGAAGGCAGGATGGAACTCGGC
CTCATCCCCGAGGCCCCAGTTCCTATATCGGGCCCCCCATTCATCCACTCACACTCCCAGCCACCATGTTACACTGGACTCTAAGCCACT

>65926_65926_5_PLAUR-MARK4_PLAUR_chr19_44174218_ENST00000340093_MARK4_chr19_45762247_ENST00000262891_length(amino acids)=732AA_BP=
MGSGRSSDKGPSWSSRSLGARCRNSIASCPEEQPHVGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIM
KGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADF
GFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRF
LVLNPAKRCTLEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKESLTSQKYNEVTATYLLLGRKTEEGGDRGAP
GLALARVRAPSDTTNGTSSSKGTSHSKGQRSSSSTYHRQRRHSDFCGPSPAPLHPKRSPTSTGEAELKEERLPGRKASCSTAGSGSRGLP
PSSPMVSSAHNPNKAEIPERRKDSTSTPNNLPPSMMTRRNTYVCTERPGAERPSLLPNGKENSSGTPRVPPASPSSHSLAPPSGERSRLA
RGSTIRSTFHGGQVRDRRAGGGGGGGVQNGPPASPTLAHEAAPLPAGRPRPTTNLFTKLTSKLTRRVADEPERIGGPEVTSCHLPWDQTE
TAPRLLRFPWSVKLTSSRPPEALMAALRQATAAARCRCRQPQPFLLACLHGGAGGPEPLSHFEVEVCQLPRPGLRGVLFRRVAGTALAFR

--------------------------------------------------------------
>65926_65926_6_PLAUR-MARK4_PLAUR_chr19_44174218_ENST00000340093_MARK4_chr19_45762247_ENST00000300843_length(transcript)=5146nt_BP=285nt
CAGGGCCGAGCCAGCCCCTTCACCACCAGCCGGCCGCGCCCCGGGAAGGGAAGTTTGTGGCGGAGGAGGTTCGTACGGGAGGAGGGGGAG
GCGCCCACGCATCTGGGGCTGACTCGCTCTTTCGCAAAACGTCTGGGAGGAGTCCCTGGGGCCACAAAACTGCCTCCTTCCTGAGGCCAG
AAGGAGAGAAGACGTGCAGGGACCCCGCGCACAGGAGCTGCCCTCGCGACATGGGTCACCCGCCGCTGCTGCCGCTGCTGCTGCTGCTCC
ACACCTGCGTCCCAGCATGGCACCTTGGGCAGTGGCCGCTCCTCGGACAAAGGCCCGTCCTGGTCCAGCCGCTCACTGGGTGCCCGTTGC
CGGAACTCCATCGCCTCCTGTCCCGAGGAGCAGCCCCACGTGGGCAACTACCGCCTGCTGAGGACCATTGGGAAGGGCAACTTTGCCAAA
GTCAAGCTGGCTCGGCACATCCTCACTGGTCGGGAGGTTGCCATCAAGATTATCGACAAAACCCAGCTGAATCCCAGCAGCCTGCAGAAG
CTGTTCCGAGAAGTCCGCATCATGAAGGGCCTAAACCACCCCAACATCGTGAAGCTCTTTGAGGTGATTGAGACTGAGAAGACGCTGTAC
CTGGTGATGGAGTACGCAAGTGCTGGAGAAGTGTTTGACTACCTCGTGTCGCATGGCCGCATGAAGGAGAAGGAAGCTCGAGCCAAGTTC
CGACAGATTGTTTCGGCTGTGCACTATTGTCACCAGAAAAATATTGTACACAGGGACCTGAAGGCTGAGAACCTCTTGCTGGATGCCGAG
GCCAACATCAAGATTGCTGACTTTGGCTTCAGCAACGAGTTCACGCTGGGATCGAAGCTGGACACGTTCTGCGGGAGCCCCCCATATGCC
GCCCCGGAGCTGTTTCAGGGCAAGAAGTACGACGGGCCGGAGGTGGACATCTGGAGCCTGGGAGTCATCCTGTACACCCTCGTCAGCGGC
TCCCTGCCCTTCGACGGGCACAACCTCAAGGAGCTGCGGGAGCGAGTACTCAGAGGGAAGTACCGGGTCCCTTTCTACATGTCAACAGAC
TGTGAGAGCATCCTGCGGAGATTTTTGGTGCTGAACCCAGCTAAACGCTGTACTCTCGAGCAAATCATGAAAGACAAATGGATCAACATC
GGCTATGAGGGTGAGGAGTTGAAGCCATACACAGAGCCCGAGGAGGACTTCGGGGACACCAAGAGAATTGAGGTGATGGTGGGTATGGGC
TACACACGGGAAGAAATCAAAGAGTCCTTGACCAGCCAGAAGTACAACGAAGTGACCGCCACCTACCTCCTGCTGGGCAGGAAGACTGAG
GAGGGTGGGGACCGGGGCGCCCCAGGGCTGGCCCTGGCACGGGTGCGGGCGCCCAGCGACACCACCAACGGAACAAGTTCCAGCAAAGGC
ACCAGCCACAGCAAAGGGCAGCGGAGTTCCTCTTCCACCTACCACCGCCAGCGCAGGCATAGCGATTTCTGTGGCCCATCCCCTGCACCC
CTGCACCCCAAACGCAGCCCGACGAGCACGGGGGAGGCGGAGCTGAAGGAGGAGCGGCTGCCAGGCCGGAAGGCGAGCTGCAGCACCGCG
GGGAGTGGGAGTCGAGGGCTGCCCCCCTCCAGCCCCATGGTCAGCAGCGCCCACAACCCCAACAAGGCAGAGATCCCAGAGCGGCGGAAG
GACAGCACGAGCACCCCCAACAACCTCCCTCCTAGCATGATGACCCGCAGAAACACCTACGTTTGCACAGAACGCCCGGGGGCTGAGCGC
CCGTCACTGTTGCCAAATGGGAAAGAAAACAGCTCAGGCACCCCACGGGTGCCCCCTGCCTCCCCCTCCAGTCACAGCCTGGCACCCCCA
TCAGGGGAGCGGAGCCGCCTGGCACGTGGTTCCACCATCCGCAGCACCTTCCATGGTGGCCAGGTCCGGGACCGGCGGGCAGGGGGTGGG
GGTGGTGGGGGTGTGCAGAATGGGCCCCCTGCCTCTCCCACACTGGCCCATGAGGCTGCACCCCTGCCCGCCGGGCGGCCCCGCCCCACC
ACCAACCTCTTCACCAAGCTGACCTCCAAACTGACCCGAAGGGTTACCCTCGATCCCTCTAAACGGCAGAACTCTAACCGCTGTGTTTCG
GGCGCCTCTCTGCCCCAGGGATCCAAGATCAGGTCGCAGACGAACCTGAGAGAATCGGGGGACCTGAGGTCACAAGTTGCCATCTACCTT
GGGATCAAACGGAAACCGCCCCCCGGCTGCTCCGATTCCCCTGGAGTGTGAAGCTGACCAGCTCGCGCCCTCCTGAGGCCCTGATGGCAG
CTCTGCGCCAGGCCACAGCAGCCGCCCGCTGCCGCTGCCGCCAGCCACAGCCGTTCCTGCTGGCCTGCCTGCACGGGGGTGCGGGCGGGC
CCGAGCCCCTGTCCCACTTCGAAGTGGAGGTCTGCCAGCTGCCCCGGCCAGGCTTGCGGGGAGTTCTCTTCCGCCGTGTGGCGGGCACCG
CCCTGGCCTTCCGCACCCTCGTCACCCGCATCTCCAACGACCTCGAGCTCTGAGCCACCACGGTCCCAGGGCCCTTACTCTTCCTCTCCC
TTGTCGCCTTCACTTCTACAGGAGGGGAAGGGGCCAGGGAGGGGATTCTCCCTTTATCATCACCTCAGTTTCCCTGAATTATATTTGGGG
GCAAAGATTGTCCCCTCTGCTGTTCTCTGGGGCCGCTCAGCACAGAAGAAGGATGAGGGGGCTCAGCGGGGGGAGCTGGCACCTTCCTGG
AGCCTCCAGCCAGTCCTGTCCTCCCTCGCCCTACCAAGAGGGCACCTGAGGAGACTTTGGGGACAGGGCAGGGGCAGGGAGGGAAACTGA
GGAAATCTTCCATTCCTCCCAACAGCTCAAAATTAGGCCTTGGGCAGGGGCAGGGAGAGCTGCTGAGCCTAAAGACTGGAGAATCTGGGG
GACTGGGAGTGGGGGTCAGAGAGGCAGATTCCTTCCCCTCCCGTCCCCTCACGCTCAAACCCCCACTTCCTGCCCCAGGCTGGCGCGGGG
CACTTTGTACAAATCCTTGTAAATACCCCACACCCTCCCCTCTGCAAAGGTCTCTTGAGGAGCTGCCGCTGTCACCTACGGTTTTTAAGT
TATTACACCCCGACCCTCCTCCTGTCAGCCCCCTCACCTGCAGCCTGTTGCCCAATAAATTTAAGAGAGTCCCCCCCTCCCCAATGCTGA
CCCTAGGATTTTCCTTCCCTGCCCTCACCTGCAAATGAGTTAAAGAAGAGGCGTGGGAATCCAGGCAGTGGTTTTTCCTTTCGGAGCCTC
GGTTTTCTCATCTGCAGAATGGGAGCGGTGGGGGTGGGAAGGTAAGGATGGTCGTGGAAGAAGGCAGGATGGAACTCGGCCTCATCCCCG
AGGCCCCAGTTCCTATATCGGGCCCCCCATTCATCCACTCACACTCCCAGCCACCATGTTACACTGGACTCTAAGCCACTTCTTACTCCA
GTAGTAAATTTATTCAATAAACAATCATTGACCCATGCCTACTCCATGCCAGGCCCAGTGCTGGACACAGAGACATGAAGCTCTGTCTGT
GGGAGACAGGGATTCTGACACAGACACCGGACAAACCATTGTCTTGGGGAGCCCAGAAGAGAAAGTGGGCAGGGTGGGGTCATTGGGGAA
GATGCTCTAGAGGAATTAATGCTGGAATGGGGTGTTGAAGGATGAGTAGGAGTTAGTTAGGCATTGAGTTTGCCCTGGGCAAAAGCCCAG
AAGTGGGAGTATGTGGTATATCTTCAGAGAACTGGGTAATTTCAGTGTGGCTGCTGTGTTGGGCATGGATGGAGAATCAGCAAGAGAAAT
GCTGTATTAGGACTAATAATCCATCTACGCTGCTTAAGCAAAAAGGTATTTGTTGGTTTATGTTACTTAATAGTCCAGGGGCACCTGGCT
TCAGGTAGGTTTGATCCAGGCATCAGGCCATTGCATCTATTTTTTCAGTGTAAGTTGAATTCTAGTAATTTTTATCAAGTAAGGGCTCCT
TTCCTGGTGGCACAGATGACTTCAGCAGTTAGAAGTTTCTATCCCTCCAGCTTTCTGCAGCAGAAAGACCCTCATTGTCAGTTTCCCAGC
AAAAGTCCCAGGGCAGACTCTCATTGGCCCAAATGGGCCATGTGATTTTCTCTAAACCAATCACTGTGACTCTAGAGTGGCCAGACTCAG
AGCTGCACTTAGTAGGGGTTCCTCAAAGGAAGGTCAAGTGTCATGAGCAGGAGAAAAGGCATGGGAGCTGGACAGATTATAGTGGTTGAA
GTCTGTGCAGTACAGAAGGGCGGAGCTTATTCACACAGCACCTTTGGGGCCAAAATGAATAAGCTGGACTTTCTCCCCATGGCACTGGGG
AACCATGGAAGTTCAGGGAACTTCAGGGAAGAGGCTTGGTCAATTCCTGAGAGCATCCTCTGTGCTGGGGACACAGTGGTAATCAAGACA
GCCCCAACACTGCCCTCATAGAGCTCACAGTCCAATGGAGGAGGCAGATGTGTCCTCAGGCAGCGACTGGGCAGGGCTGGTATAGGGGAG
TCCAGAGGTGATGCCTGCCTCAGCCAGGGAGGGCTTCCTGGAGGAGAAGGAGCCAGCTAGACATGGATAGGAGTGCGTTTTAGGCACAGC
AAATGGCACATACAAGGGCCAGGGAGCAAGAGAGAGGACAGGTCCTCAACAAATGGCATGTGACTTTGTAAGTGTAGAATTGCTGTGAGG
TATGGGGCTAGGGGCGTCAGTAGGGCCTTGAAGGTTATGGACAGGGGCCTGGGCTTTCTTCCAAGGGCACTGGGGGAGCCATGGCAAGGT
TGTAGGTAGGGTAGAGATGGGCGGGTTTGTGCTATGTGCAGGGTGGAAGGGAGGGAAGTTGACAGGTCAGAAGATCAGGAAAGAGGTCGG
GGCTGGACAGATGGGGAGAGCGCAGATAGATTTAAGAGAGTCCTGTGAGGCAAAGTGGGCAGGACCTGGTAACAGGTGTCTGGACTGTGG
CTTTGGCTGGCTCAGAAGGTCCCCACTGGCGTGTGTGGTCTATGTAGCCTCTGGGTGTGGAGCTGGGATCTTCAACTGGGGACAGTACAG

>65926_65926_6_PLAUR-MARK4_PLAUR_chr19_44174218_ENST00000340093_MARK4_chr19_45762247_ENST00000300843_length(amino acids)=668AA_BP=
MGSGRSSDKGPSWSSRSLGARCRNSIASCPEEQPHVGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIM
KGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADF
GFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRF
LVLNPAKRCTLEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKESLTSQKYNEVTATYLLLGRKTEEGGDRGAP
GLALARVRAPSDTTNGTSSSKGTSHSKGQRSSSSTYHRQRRHSDFCGPSPAPLHPKRSPTSTGEAELKEERLPGRKASCSTAGSGSRGLP
PSSPMVSSAHNPNKAEIPERRKDSTSTPNNLPPSMMTRRNTYVCTERPGAERPSLLPNGKENSSGTPRVPPASPSSHSLAPPSGERSRLA
RGSTIRSTFHGGQVRDRRAGGGGGGGVQNGPPASPTLAHEAAPLPAGRPRPTTNLFTKLTSKLTRRVTLDPSKRQNSNRCVSGASLPQGS

--------------------------------------------------------------
>65926_65926_7_PLAUR-MARK4_PLAUR_chr19_44174218_ENST00000601723_MARK4_chr19_45762247_ENST00000262891_length(transcript)=3279nt_BP=88nt
AGGGACCCCGCGCACAGGAGCTGCCCTCGCGACATGGGTCACCCGCCGCTGCTGCCGCTGCTGCTGCTGCTCCACACCTGCGTCCCAGCA
TGGCACCTTGGGCAGTGGCCGCTCCTCGGACAAAGGCCCGTCCTGGTCCAGCCGCTCACTGGGTGCCCGTTGCCGGAACTCCATCGCCTC
CTGTCCCGAGGAGCAGCCCCACGTGGGCAACTACCGCCTGCTGAGGACCATTGGGAAGGGCAACTTTGCCAAAGTCAAGCTGGCTCGGCA
CATCCTCACTGGTCGGGAGGTTGCCATCAAGATTATCGACAAAACCCAGCTGAATCCCAGCAGCCTGCAGAAGCTGTTCCGAGAAGTCCG
CATCATGAAGGGCCTAAACCACCCCAACATCGTGAAGCTCTTTGAGGTGATTGAGACTGAGAAGACGCTGTACCTGGTGATGGAGTACGC
AAGTGCTGGAGAAGTGTTTGACTACCTCGTGTCGCATGGCCGCATGAAGGAGAAGGAAGCTCGAGCCAAGTTCCGACAGATTGTTTCGGC
TGTGCACTATTGTCACCAGAAAAATATTGTACACAGGGACCTGAAGGCTGAGAACCTCTTGCTGGATGCCGAGGCCAACATCAAGATTGC
TGACTTTGGCTTCAGCAACGAGTTCACGCTGGGATCGAAGCTGGACACGTTCTGCGGGAGCCCCCCATATGCCGCCCCGGAGCTGTTTCA
GGGCAAGAAGTACGACGGGCCGGAGGTGGACATCTGGAGCCTGGGAGTCATCCTGTACACCCTCGTCAGCGGCTCCCTGCCCTTCGACGG
GCACAACCTCAAGGAGCTGCGGGAGCGAGTACTCAGAGGGAAGTACCGGGTCCCTTTCTACATGTCAACAGACTGTGAGAGCATCCTGCG
GAGATTTTTGGTGCTGAACCCAGCTAAACGCTGTACTCTCGAGCAAATCATGAAAGACAAATGGATCAACATCGGCTATGAGGGTGAGGA
GTTGAAGCCATACACAGAGCCCGAGGAGGACTTCGGGGACACCAAGAGAATTGAGGTGATGGTGGGTATGGGCTACACACGGGAAGAAAT
CAAAGAGTCCTTGACCAGCCAGAAGTACAACGAAGTGACCGCCACCTACCTCCTGCTGGGCAGGAAGACTGAGGAGGGTGGGGACCGGGG
CGCCCCAGGGCTGGCCCTGGCACGGGTGCGGGCGCCCAGCGACACCACCAACGGAACAAGTTCCAGCAAAGGCACCAGCCACAGCAAAGG
GCAGCGGAGTTCCTCTTCCACCTACCACCGCCAGCGCAGGCATAGCGATTTCTGTGGCCCATCCCCTGCACCCCTGCACCCCAAACGCAG
CCCGACGAGCACGGGGGAGGCGGAGCTGAAGGAGGAGCGGCTGCCAGGCCGGAAGGCGAGCTGCAGCACCGCGGGGAGTGGGAGTCGAGG
GCTGCCCCCCTCCAGCCCCATGGTCAGCAGCGCCCACAACCCCAACAAGGCAGAGATCCCAGAGCGGCGGAAGGACAGCACGAGCACCCC
CAACAACCTCCCTCCTAGCATGATGACCCGCAGAAACACCTACGTTTGCACAGAACGCCCGGGGGCTGAGCGCCCGTCACTGTTGCCAAA
TGGGAAAGAAAACAGCTCAGGCACCCCACGGGTGCCCCCTGCCTCCCCCTCCAGTCACAGCCTGGCACCCCCATCAGGGGAGCGGAGCCG
CCTGGCACGTGGTTCCACCATCCGCAGCACCTTCCATGGTGGCCAGGTCCGGGACCGGCGGGCAGGGGGTGGGGGTGGTGGGGGTGTGCA
GAATGGGCCCCCTGCCTCTCCCACACTGGCCCATGAGGCTGCACCCCTGCCCGCCGGGCGGCCCCGCCCCACCACCAACCTCTTCACCAA
GCTGACCTCCAAACTGACCCGAAGGGTCGCAGACGAACCTGAGAGAATCGGGGGACCTGAGGTCACAAGTTGCCATCTACCTTGGGATCA
AACGGAAACCGCCCCCCGGCTGCTCCGATTCCCCTGGAGTGTGAAGCTGACCAGCTCGCGCCCTCCTGAGGCCCTGATGGCAGCTCTGCG
CCAGGCCACAGCAGCCGCCCGCTGCCGCTGCCGCCAGCCACAGCCGTTCCTGCTGGCCTGCCTGCACGGGGGTGCGGGCGGGCCCGAGCC
CCTGTCCCACTTCGAAGTGGAGGTCTGCCAGCTGCCCCGGCCAGGCTTGCGGGGAGTTCTCTTCCGCCGTGTGGCGGGCACCGCCCTGGC
CTTCCGCACCCTCGTCACCCGCATCTCCAACGACCTCGAGCTCTGAGCCACCACGGTCCCAGGGCCCTTACTCTTCCTCTCCCTTGTCGC
CTTCACTTCTACAGGAGGGGAAGGGGCCAGGGAGGGGATTCTCCCTTTATCATCACCTCAGTTTCCCTGAATTATATTTGGGGGCAAAGA
TTGTCCCCTCTGCTGTTCTCTGGGGCCGCTCAGCACAGAAGAAGGATGAGGGGGCTCAGCGGGGGGAGCTGGCACCTTCCTGGAGCCTCC
AGCCAGTCCTGTCCTCCCTCGCCCTACCAAGAGGGCACCTGAGGAGACTTTGGGGACAGGGCAGGGGCAGGGAGGGAAACTGAGGAAATC
TTCCATTCCTCCCAACAGCTCAAAATTAGGCCTTGGGCAGGGGCAGGGAGAGCTGCTGAGCCTAAAGACTGGAGAATCTGGGGGACTGGG
AGTGGGGGTCAGAGAGGCAGATTCCTTCCCCTCCCGTCCCCTCACGCTCAAACCCCCACTTCCTGCCCCAGGCTGGCGCGGGGCACTTTG
TACAAATCCTTGTAAATACCCCACACCCTCCCCTCTGCAAAGGTCTCTTGAGGAGCTGCCGCTGTCACCTACGGTTTTTAAGTTATTACA
CCCCGACCCTCCTCCTGTCAGCCCCCTCACCTGCAGCCTGTTGCCCAATAAATTTAAGAGAGTCCCCCCCTCCCCAATGCTGACCCTAGG
ATTTTCCTTCCCTGCCCTCACCTGCAAATGAGTTAAAGAAGAGGCGTGGGAATCCAGGCAGTGGTTTTTCCTTTCGGAGCCTCGGTTTTC
TCATCTGCAGAATGGGAGCGGTGGGGGTGGGAAGGTAAGGATGGTCGTGGAAGAAGGCAGGATGGAACTCGGCCTCATCCCCGAGGCCCC
AGTTCCTATATCGGGCCCCCCATTCATCCACTCACACTCCCAGCCACCATGTTACACTGGACTCTAAGCCACTTCTTACTCCAGTAGTAA

>65926_65926_7_PLAUR-MARK4_PLAUR_chr19_44174218_ENST00000601723_MARK4_chr19_45762247_ENST00000262891_length(amino acids)=732AA_BP=
MGSGRSSDKGPSWSSRSLGARCRNSIASCPEEQPHVGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIM
KGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADF
GFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRF
LVLNPAKRCTLEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKESLTSQKYNEVTATYLLLGRKTEEGGDRGAP
GLALARVRAPSDTTNGTSSSKGTSHSKGQRSSSSTYHRQRRHSDFCGPSPAPLHPKRSPTSTGEAELKEERLPGRKASCSTAGSGSRGLP
PSSPMVSSAHNPNKAEIPERRKDSTSTPNNLPPSMMTRRNTYVCTERPGAERPSLLPNGKENSSGTPRVPPASPSSHSLAPPSGERSRLA
RGSTIRSTFHGGQVRDRRAGGGGGGGVQNGPPASPTLAHEAAPLPAGRPRPTTNLFTKLTSKLTRRVADEPERIGGPEVTSCHLPWDQTE
TAPRLLRFPWSVKLTSSRPPEALMAALRQATAAARCRCRQPQPFLLACLHGGAGGPEPLSHFEVEVCQLPRPGLRGVLFRRVAGTALAFR

--------------------------------------------------------------
>65926_65926_8_PLAUR-MARK4_PLAUR_chr19_44174218_ENST00000601723_MARK4_chr19_45762247_ENST00000300843_length(transcript)=4949nt_BP=88nt
AGGGACCCCGCGCACAGGAGCTGCCCTCGCGACATGGGTCACCCGCCGCTGCTGCCGCTGCTGCTGCTGCTCCACACCTGCGTCCCAGCA
TGGCACCTTGGGCAGTGGCCGCTCCTCGGACAAAGGCCCGTCCTGGTCCAGCCGCTCACTGGGTGCCCGTTGCCGGAACTCCATCGCCTC
CTGTCCCGAGGAGCAGCCCCACGTGGGCAACTACCGCCTGCTGAGGACCATTGGGAAGGGCAACTTTGCCAAAGTCAAGCTGGCTCGGCA
CATCCTCACTGGTCGGGAGGTTGCCATCAAGATTATCGACAAAACCCAGCTGAATCCCAGCAGCCTGCAGAAGCTGTTCCGAGAAGTCCG
CATCATGAAGGGCCTAAACCACCCCAACATCGTGAAGCTCTTTGAGGTGATTGAGACTGAGAAGACGCTGTACCTGGTGATGGAGTACGC
AAGTGCTGGAGAAGTGTTTGACTACCTCGTGTCGCATGGCCGCATGAAGGAGAAGGAAGCTCGAGCCAAGTTCCGACAGATTGTTTCGGC
TGTGCACTATTGTCACCAGAAAAATATTGTACACAGGGACCTGAAGGCTGAGAACCTCTTGCTGGATGCCGAGGCCAACATCAAGATTGC
TGACTTTGGCTTCAGCAACGAGTTCACGCTGGGATCGAAGCTGGACACGTTCTGCGGGAGCCCCCCATATGCCGCCCCGGAGCTGTTTCA
GGGCAAGAAGTACGACGGGCCGGAGGTGGACATCTGGAGCCTGGGAGTCATCCTGTACACCCTCGTCAGCGGCTCCCTGCCCTTCGACGG
GCACAACCTCAAGGAGCTGCGGGAGCGAGTACTCAGAGGGAAGTACCGGGTCCCTTTCTACATGTCAACAGACTGTGAGAGCATCCTGCG
GAGATTTTTGGTGCTGAACCCAGCTAAACGCTGTACTCTCGAGCAAATCATGAAAGACAAATGGATCAACATCGGCTATGAGGGTGAGGA
GTTGAAGCCATACACAGAGCCCGAGGAGGACTTCGGGGACACCAAGAGAATTGAGGTGATGGTGGGTATGGGCTACACACGGGAAGAAAT
CAAAGAGTCCTTGACCAGCCAGAAGTACAACGAAGTGACCGCCACCTACCTCCTGCTGGGCAGGAAGACTGAGGAGGGTGGGGACCGGGG
CGCCCCAGGGCTGGCCCTGGCACGGGTGCGGGCGCCCAGCGACACCACCAACGGAACAAGTTCCAGCAAAGGCACCAGCCACAGCAAAGG
GCAGCGGAGTTCCTCTTCCACCTACCACCGCCAGCGCAGGCATAGCGATTTCTGTGGCCCATCCCCTGCACCCCTGCACCCCAAACGCAG
CCCGACGAGCACGGGGGAGGCGGAGCTGAAGGAGGAGCGGCTGCCAGGCCGGAAGGCGAGCTGCAGCACCGCGGGGAGTGGGAGTCGAGG
GCTGCCCCCCTCCAGCCCCATGGTCAGCAGCGCCCACAACCCCAACAAGGCAGAGATCCCAGAGCGGCGGAAGGACAGCACGAGCACCCC
CAACAACCTCCCTCCTAGCATGATGACCCGCAGAAACACCTACGTTTGCACAGAACGCCCGGGGGCTGAGCGCCCGTCACTGTTGCCAAA
TGGGAAAGAAAACAGCTCAGGCACCCCACGGGTGCCCCCTGCCTCCCCCTCCAGTCACAGCCTGGCACCCCCATCAGGGGAGCGGAGCCG
CCTGGCACGTGGTTCCACCATCCGCAGCACCTTCCATGGTGGCCAGGTCCGGGACCGGCGGGCAGGGGGTGGGGGTGGTGGGGGTGTGCA
GAATGGGCCCCCTGCCTCTCCCACACTGGCCCATGAGGCTGCACCCCTGCCCGCCGGGCGGCCCCGCCCCACCACCAACCTCTTCACCAA
GCTGACCTCCAAACTGACCCGAAGGGTTACCCTCGATCCCTCTAAACGGCAGAACTCTAACCGCTGTGTTTCGGGCGCCTCTCTGCCCCA
GGGATCCAAGATCAGGTCGCAGACGAACCTGAGAGAATCGGGGGACCTGAGGTCACAAGTTGCCATCTACCTTGGGATCAAACGGAAACC
GCCCCCCGGCTGCTCCGATTCCCCTGGAGTGTGAAGCTGACCAGCTCGCGCCCTCCTGAGGCCCTGATGGCAGCTCTGCGCCAGGCCACA
GCAGCCGCCCGCTGCCGCTGCCGCCAGCCACAGCCGTTCCTGCTGGCCTGCCTGCACGGGGGTGCGGGCGGGCCCGAGCCCCTGTCCCAC
TTCGAAGTGGAGGTCTGCCAGCTGCCCCGGCCAGGCTTGCGGGGAGTTCTCTTCCGCCGTGTGGCGGGCACCGCCCTGGCCTTCCGCACC
CTCGTCACCCGCATCTCCAACGACCTCGAGCTCTGAGCCACCACGGTCCCAGGGCCCTTACTCTTCCTCTCCCTTGTCGCCTTCACTTCT
ACAGGAGGGGAAGGGGCCAGGGAGGGGATTCTCCCTTTATCATCACCTCAGTTTCCCTGAATTATATTTGGGGGCAAAGATTGTCCCCTC
TGCTGTTCTCTGGGGCCGCTCAGCACAGAAGAAGGATGAGGGGGCTCAGCGGGGGGAGCTGGCACCTTCCTGGAGCCTCCAGCCAGTCCT
GTCCTCCCTCGCCCTACCAAGAGGGCACCTGAGGAGACTTTGGGGACAGGGCAGGGGCAGGGAGGGAAACTGAGGAAATCTTCCATTCCT
CCCAACAGCTCAAAATTAGGCCTTGGGCAGGGGCAGGGAGAGCTGCTGAGCCTAAAGACTGGAGAATCTGGGGGACTGGGAGTGGGGGTC
AGAGAGGCAGATTCCTTCCCCTCCCGTCCCCTCACGCTCAAACCCCCACTTCCTGCCCCAGGCTGGCGCGGGGCACTTTGTACAAATCCT
TGTAAATACCCCACACCCTCCCCTCTGCAAAGGTCTCTTGAGGAGCTGCCGCTGTCACCTACGGTTTTTAAGTTATTACACCCCGACCCT
CCTCCTGTCAGCCCCCTCACCTGCAGCCTGTTGCCCAATAAATTTAAGAGAGTCCCCCCCTCCCCAATGCTGACCCTAGGATTTTCCTTC
CCTGCCCTCACCTGCAAATGAGTTAAAGAAGAGGCGTGGGAATCCAGGCAGTGGTTTTTCCTTTCGGAGCCTCGGTTTTCTCATCTGCAG
AATGGGAGCGGTGGGGGTGGGAAGGTAAGGATGGTCGTGGAAGAAGGCAGGATGGAACTCGGCCTCATCCCCGAGGCCCCAGTTCCTATA
TCGGGCCCCCCATTCATCCACTCACACTCCCAGCCACCATGTTACACTGGACTCTAAGCCACTTCTTACTCCAGTAGTAAATTTATTCAA
TAAACAATCATTGACCCATGCCTACTCCATGCCAGGCCCAGTGCTGGACACAGAGACATGAAGCTCTGTCTGTGGGAGACAGGGATTCTG
ACACAGACACCGGACAAACCATTGTCTTGGGGAGCCCAGAAGAGAAAGTGGGCAGGGTGGGGTCATTGGGGAAGATGCTCTAGAGGAATT
AATGCTGGAATGGGGTGTTGAAGGATGAGTAGGAGTTAGTTAGGCATTGAGTTTGCCCTGGGCAAAAGCCCAGAAGTGGGAGTATGTGGT
ATATCTTCAGAGAACTGGGTAATTTCAGTGTGGCTGCTGTGTTGGGCATGGATGGAGAATCAGCAAGAGAAATGCTGTATTAGGACTAAT
AATCCATCTACGCTGCTTAAGCAAAAAGGTATTTGTTGGTTTATGTTACTTAATAGTCCAGGGGCACCTGGCTTCAGGTAGGTTTGATCC
AGGCATCAGGCCATTGCATCTATTTTTTCAGTGTAAGTTGAATTCTAGTAATTTTTATCAAGTAAGGGCTCCTTTCCTGGTGGCACAGAT
GACTTCAGCAGTTAGAAGTTTCTATCCCTCCAGCTTTCTGCAGCAGAAAGACCCTCATTGTCAGTTTCCCAGCAAAAGTCCCAGGGCAGA
CTCTCATTGGCCCAAATGGGCCATGTGATTTTCTCTAAACCAATCACTGTGACTCTAGAGTGGCCAGACTCAGAGCTGCACTTAGTAGGG
GTTCCTCAAAGGAAGGTCAAGTGTCATGAGCAGGAGAAAAGGCATGGGAGCTGGACAGATTATAGTGGTTGAAGTCTGTGCAGTACAGAA
GGGCGGAGCTTATTCACACAGCACCTTTGGGGCCAAAATGAATAAGCTGGACTTTCTCCCCATGGCACTGGGGAACCATGGAAGTTCAGG
GAACTTCAGGGAAGAGGCTTGGTCAATTCCTGAGAGCATCCTCTGTGCTGGGGACACAGTGGTAATCAAGACAGCCCCAACACTGCCCTC
ATAGAGCTCACAGTCCAATGGAGGAGGCAGATGTGTCCTCAGGCAGCGACTGGGCAGGGCTGGTATAGGGGAGTCCAGAGGTGATGCCTG
CCTCAGCCAGGGAGGGCTTCCTGGAGGAGAAGGAGCCAGCTAGACATGGATAGGAGTGCGTTTTAGGCACAGCAAATGGCACATACAAGG
GCCAGGGAGCAAGAGAGAGGACAGGTCCTCAACAAATGGCATGTGACTTTGTAAGTGTAGAATTGCTGTGAGGTATGGGGCTAGGGGCGT
CAGTAGGGCCTTGAAGGTTATGGACAGGGGCCTGGGCTTTCTTCCAAGGGCACTGGGGGAGCCATGGCAAGGTTGTAGGTAGGGTAGAGA
TGGGCGGGTTTGTGCTATGTGCAGGGTGGAAGGGAGGGAAGTTGACAGGTCAGAAGATCAGGAAAGAGGTCGGGGCTGGACAGATGGGGA
GAGCGCAGATAGATTTAAGAGAGTCCTGTGAGGCAAAGTGGGCAGGACCTGGTAACAGGTGTCTGGACTGTGGCTTTGGCTGGCTCAGAA

>65926_65926_8_PLAUR-MARK4_PLAUR_chr19_44174218_ENST00000601723_MARK4_chr19_45762247_ENST00000300843_length(amino acids)=668AA_BP=
MGSGRSSDKGPSWSSRSLGARCRNSIASCPEEQPHVGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIM
KGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADF
GFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRF
LVLNPAKRCTLEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKESLTSQKYNEVTATYLLLGRKTEEGGDRGAP
GLALARVRAPSDTTNGTSSSKGTSHSKGQRSSSSTYHRQRRHSDFCGPSPAPLHPKRSPTSTGEAELKEERLPGRKASCSTAGSGSRGLP
PSSPMVSSAHNPNKAEIPERRKDSTSTPNNLPPSMMTRRNTYVCTERPGAERPSLLPNGKENSSGTPRVPPASPSSHSLAPPSGERSRLA
RGSTIRSTFHGGQVRDRRAGGGGGGGVQNGPPASPTLAHEAAPLPAGRPRPTTNLFTKLTSKLTRRVTLDPSKRQNSNRCVSGASLPQGS

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Fusion Gene PPI Analysis for PLAUR-MARK4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PLAUR-MARK4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PLAUR-MARK4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource