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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:PLAUR-XRCC1 (FusionGDB2 ID:65931)

Fusion Gene Summary for PLAUR-XRCC1

Fusion gene summary

Fusion gene information	Fusion gene name: PLAUR-XRCC1
	Fusion gene ID: 65931
		Hgene	Tgene
	Gene symbol	PLAUR	XRCC1
	Gene ID	5329	7515
	Gene name	plasminogen activator, urokinase receptor	X-ray repair cross complementing 1
	Synonyms	CD87\|U-PAR\|UPAR\|URKR	RCC\|SCAR26
	Cytomap	19q13.31	19q13.31
	Type of gene	protein-coding	protein-coding
	Description	urokinase plasminogen activator surface receptormonocyte activation antigen Mo3u-plasminogen activator receptor form 2urokinase-type plasminogen activator (uPA) receptor	DNA repair protein XRCC1X-ray repair complementing defective repair in Chinese hamster cells 1X-ray repair cross-complementing protein 1
	Modification date	20200329	20200329
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000221264, ENST00000339082, ENST00000340093, ENST00000601723,	ENST00000262887, ENST00000543982,
Fusion gene scores	* DoF score	9 X 6 X 8=432	4 X 4 X 4=64
	# samples	10	5
	** MAII score	log2(10/432*10)=-2.11103131238874 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/64*10)=-0.356143810225275 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: PLAUR [Title/Abstract] AND XRCC1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	PLAUR(44156377)-XRCC1(44050258), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PLAUR	GO:0043388	positive regulation of DNA binding	22984561
Tgene	XRCC1	GO:0033194	response to hydroperoxide	28002403

Fusion gene breakpoints across PLAUR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across XRCC1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUAD	TCGA-55-8094-01A	PLAUR	chr19	44156377	-	XRCC1	chr19	44050258	-

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Fusion Gene ORF analysis for PLAUR-XRCC1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000221264	ENST00000262887	PLAUR	chr19	44156377	-	XRCC1	chr19	44050258	-
In-frame	ENST00000221264	ENST00000543982	PLAUR	chr19	44156377	-	XRCC1	chr19	44050258	-
In-frame	ENST00000339082	ENST00000262887	PLAUR	chr19	44156377	-	XRCC1	chr19	44050258	-
In-frame	ENST00000339082	ENST00000543982	PLAUR	chr19	44156377	-	XRCC1	chr19	44050258	-
In-frame	ENST00000340093	ENST00000262887	PLAUR	chr19	44156377	-	XRCC1	chr19	44050258	-
In-frame	ENST00000340093	ENST00000543982	PLAUR	chr19	44156377	-	XRCC1	chr19	44050258	-
intron-3CDS	ENST00000601723	ENST00000262887	PLAUR	chr19	44156377	-	XRCC1	chr19	44050258	-
intron-3CDS	ENST00000601723	ENST00000543982	PLAUR	chr19	44156377	-	XRCC1	chr19	44050258	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000339082	PLAUR	chr19	44156377	-	ENST00000262887	XRCC1	chr19	44050258	-	1628	800	46	1275	409
ENST00000339082	PLAUR	chr19	44156377	-	ENST00000543982	XRCC1	chr19	44050258	-	1356	800	46	1275	409
ENST00000340093	PLAUR	chr19	44156377	-	ENST00000262887	XRCC1	chr19	44050258	-	1812	984	170	1459	429
ENST00000340093	PLAUR	chr19	44156377	-	ENST00000543982	XRCC1	chr19	44050258	-	1540	984	170	1459	429
ENST00000221264	PLAUR	chr19	44156377	-	ENST00000262887	XRCC1	chr19	44050258	-	1874	1046	367	1521	384
ENST00000221264	PLAUR	chr19	44156377	-	ENST00000543982	XRCC1	chr19	44050258	-	1602	1046	367	1521	384

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000339082	ENST00000262887	PLAUR	chr19	44156377	-	XRCC1	chr19	44050258	-	0.003497445	0.9965025
ENST00000339082	ENST00000543982	PLAUR	chr19	44156377	-	XRCC1	chr19	44050258	-	0.003237134	0.9967629
ENST00000340093	ENST00000262887	PLAUR	chr19	44156377	-	XRCC1	chr19	44050258	-	0.002822439	0.9971776
ENST00000340093	ENST00000543982	PLAUR	chr19	44156377	-	XRCC1	chr19	44050258	-	0.002536311	0.9974637
ENST00000221264	ENST00000262887	PLAUR	chr19	44156377	-	XRCC1	chr19	44050258	-	0.00236695	0.997633
ENST00000221264	ENST00000543982	PLAUR	chr19	44156377	-	XRCC1	chr19	44050258	-	0.002000538	0.9979995

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Fusion Genomic Features for PLAUR-XRCC1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PLAUR-XRCC1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:44156377/chr19:44050258)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PLAUR

chr19:44156377

chr19:44050258

ENST00000221264

23_114

206

291.0

Domain

Note=UPAR/Ly6 1

Hgene

PLAUR

chr19:44156377

chr19:44050258

ENST00000339082

115_213

251

282.0

Domain

Note=UPAR/Ly6 2

Hgene

PLAUR

chr19:44156377

chr19:44050258

ENST00000339082

23_114

251

282.0

Domain

Note=UPAR/Ly6 1

Hgene

PLAUR

chr19:44156377

chr19:44050258

ENST00000340093

115_213

251

336.0

Domain

Note=UPAR/Ly6 2

Hgene

PLAUR

chr19:44156377

chr19:44050258

ENST00000340093

23_114

251

336.0

Domain

Note=UPAR/Ly6 1

Tgene

XRCC1

chr19:44156377

chr19:44050258

ENST00000262887

538_629

475

634.0

Domain

BRCT 2

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PLAUR

chr19:44156377

chr19:44050258

ENST00000221264

115_213

206

291.0

Domain

Note=UPAR/Ly6 2

Hgene

PLAUR

chr19:44156377

chr19:44050258

ENST00000221264

214_305

206

291.0

Domain

Note=UPAR/Ly6 3

Hgene

PLAUR

chr19:44156377

chr19:44050258

ENST00000339082

214_305

251

282.0

Domain

Note=UPAR/Ly6 3

Hgene

PLAUR

chr19:44156377

chr19:44050258

ENST00000340093

214_305

251

336.0

Domain

Note=UPAR/Ly6 3

Tgene

XRCC1

chr19:44156377

chr19:44050258

ENST00000262887

315_403

475

634.0

Domain

BRCT 1

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Fusion Gene Sequence for PLAUR-XRCC1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>65931_65931_1_PLAUR-XRCC1_PLAUR_chr19_44156377_ENST00000221264_XRCC1_chr19_44050258_ENST00000262887_length(transcript)=1874nt_BP=1046nt
CAGTATCCCTCCTGACAAAACTAACAAAAATCCTGTTAGCCAAATAATCAGCCACATTCATATTTACCGTCAAAGTTTTTATCCTCATTT
TACAGCAGTGGAGAGCGATTGCCCCGGGTCCCACGTTAGGAAGAGAGAGAACTGGGATTTGCACCCAGGCAATCTGGGGACAGAGCTGTG
ATCACAACTCCATGAGTCAGGGCCGAGCCAGCCCCTTCACCACCAGCCGGCCGCGCCCCGGGAAGGGAAGTTTGTGGCGGAGGAGGTTCG
TACGGGAGGAGGGGGAGGCGCCCACGCATCTGGGGCTGACTCGCTCTTTCGCAAAACGTCTGGGAGGAGTCCCTGGGGCCACAAAACTGC
CTCCTTCCTGAGGCCAGAAGGAGAGAAGACGTGCAGGGACCCCGCGCACAGGAGCTGCCCTCGCGACATGGGTCACCCGCCGCTGCTGCC
GCTGCTGCTGCTGCTCCACACCTGCGTCCCAGCCTCTTGGGGCCTGCGGTGCATGCAGTGTAAGACCAACGGGGATTGCCGTGTGGAAGA
GTGCGCCCTGGGACAGGACCTCTGCAGGACCACGATCGTGCGCTTGTGGGAAGAAGGAGAAGAGCTGGAGCTGGTGGAGAAAAGCTGTAC
CCACTCAGAGAAGACCAACAGGACCCTGAGCTATCGGACTGGCTTGAAGATCACCAGCCTTACCGAGGTTGTGTGTGGGTTAGACTTGTG
CAACCAGGGCAACTCTGGCCGGGCTGTCACCTATTCCCGAAGCCGTTACCTCGAATGCATTTCCTGTGGCTCATCAGACATGAGCTGTGA
GAGGGGCCGGCACCAGAGCCTGCAGTGCCGCAGCCCTGAAGAACAGTGCCTGGATGTGGTGACCCACTGGATCCAGGAAGGTGAAGAAGT
CCTGGAGCTTGAAAATCTGCCGCAGAATGGCCGCCAGTGTTACAGCTGCAAGGGGAACAGCACCCATGGATGCTCCTCTGAAGAGACTTT
CCTCATTGACTGCCGAGGCCCCATGAATCAATGTCTGGTAGCCACCGGCACTCACGAAGGACAGGACAATGGGGCGGAAGATTCTGGGGA
CACAGAGGATGAGCTGAGGAGGGTGGCAGAGCAGAAGGAACACAGACTGCCCCCTGGCCAGGAGGAGAATGGGGAAGACCCGTATGCAGG
CTCCACGGATGAGAACACGGACAGTGAGGAACACCAGGAGCCTCCTGATCTGCCAGTCCCTGAGCTCCCAGATTTCTTCCAGGGCAAGCA
CTTCTTTCTTTACGGGGAGTTCCCTGGGGACGAGCGGCGGAAACTCATCCGATACGTCACAGCCTTCAATGGGGAGCTCGAGGACAATAT
GAGTGACCGGGTTCAGTTTGTGATCACAGCACAGGAATGGGATCCCAGCTTTGAGGAGGCCCTGATGGACAACCCCTCCCTGGCATTCGT
TCGTCCCCGATGGATCTACAGTTGCAATGAGAAGCAGAAGTTACTTCCTCACCAGCTCTATGGGGTGGTGCCGCAAGCCTGAAGTATGTG
CTATACACACACACACACACACACACACACACACACACACACGATGCATTTAATAAAGATGAGTTGGTTCTCATCCAAGAGTCTCCCAAA
ACTCTAAGAGGCTCCCTGGGACCTGGGGAAGAATGCTGGGCACCTCCGTCAGAGATCTGGTAGAGAAGGAACTCTTTGTCTCTTCTGCTT
GGCCCCTTATCCCTGTGTTGGCAAGAGGCAGGGAACTGGGAATCTGACCCTCAGCACTGCCCCTCAACTTTTTCTGGCCCTCTGAGCCAC

>65931_65931_1_PLAUR-XRCC1_PLAUR_chr19_44156377_ENST00000221264_XRCC1_chr19_44050258_ENST00000262887_length(amino acids)=384AA_BP=1
MRPEGEKTCRDPAHRSCPRDMGHPPLLPLLLLLHTCVPASWGLRCMQCKTNGDCRVEECALGQDLCRTTIVRLWEEGEELELVEKSCTHS
EKTNRTLSYRTGLKITSLTEVVCGLDLCNQGNSGRAVTYSRSRYLECISCGSSDMSCERGRHQSLQCRSPEEQCLDVVTHWIQEGEEVLE
LENLPQNGRQCYSCKGNSTHGCSSEETFLIDCRGPMNQCLVATGTHEGQDNGAEDSGDTEDELRRVAEQKEHRLPPGQEENGEDPYAGST
DENTDSEEHQEPPDLPVPELPDFFQGKHFFLYGEFPGDERRKLIRYVTAFNGELEDNMSDRVQFVITAQEWDPSFEEALMDNPSLAFVRP

--------------------------------------------------------------
>65931_65931_2_PLAUR-XRCC1_PLAUR_chr19_44156377_ENST00000221264_XRCC1_chr19_44050258_ENST00000543982_length(transcript)=1602nt_BP=1046nt
CAGTATCCCTCCTGACAAAACTAACAAAAATCCTGTTAGCCAAATAATCAGCCACATTCATATTTACCGTCAAAGTTTTTATCCTCATTT
TACAGCAGTGGAGAGCGATTGCCCCGGGTCCCACGTTAGGAAGAGAGAGAACTGGGATTTGCACCCAGGCAATCTGGGGACAGAGCTGTG
ATCACAACTCCATGAGTCAGGGCCGAGCCAGCCCCTTCACCACCAGCCGGCCGCGCCCCGGGAAGGGAAGTTTGTGGCGGAGGAGGTTCG
TACGGGAGGAGGGGGAGGCGCCCACGCATCTGGGGCTGACTCGCTCTTTCGCAAAACGTCTGGGAGGAGTCCCTGGGGCCACAAAACTGC
CTCCTTCCTGAGGCCAGAAGGAGAGAAGACGTGCAGGGACCCCGCGCACAGGAGCTGCCCTCGCGACATGGGTCACCCGCCGCTGCTGCC
GCTGCTGCTGCTGCTCCACACCTGCGTCCCAGCCTCTTGGGGCCTGCGGTGCATGCAGTGTAAGACCAACGGGGATTGCCGTGTGGAAGA
GTGCGCCCTGGGACAGGACCTCTGCAGGACCACGATCGTGCGCTTGTGGGAAGAAGGAGAAGAGCTGGAGCTGGTGGAGAAAAGCTGTAC
CCACTCAGAGAAGACCAACAGGACCCTGAGCTATCGGACTGGCTTGAAGATCACCAGCCTTACCGAGGTTGTGTGTGGGTTAGACTTGTG
CAACCAGGGCAACTCTGGCCGGGCTGTCACCTATTCCCGAAGCCGTTACCTCGAATGCATTTCCTGTGGCTCATCAGACATGAGCTGTGA
GAGGGGCCGGCACCAGAGCCTGCAGTGCCGCAGCCCTGAAGAACAGTGCCTGGATGTGGTGACCCACTGGATCCAGGAAGGTGAAGAAGT
CCTGGAGCTTGAAAATCTGCCGCAGAATGGCCGCCAGTGTTACAGCTGCAAGGGGAACAGCACCCATGGATGCTCCTCTGAAGAGACTTT
CCTCATTGACTGCCGAGGCCCCATGAATCAATGTCTGGTAGCCACCGGCACTCACGAAGGACAGGACAATGGGGCGGAAGATTCTGGGGA
CACAGAGGATGAGCTGAGGAGGGTGGCAGAGCAGAAGGAACACAGACTGCCCCCTGGCCAGGAGGAGAATGGGGAAGACCCGTATGCAGG
CTCCACGGATGAGAACACGGACAGTGAGGAACACCAGGAGCCTCCTGATCTGCCAGTCCCTGAGCTCCCAGATTTCTTCCAGGGCAAGCA
CTTCTTTCTTTACGGGGAGTTCCCTGGGGACGAGCGGCGGAAACTCATCCGATACGTCACAGCCTTCAATGGGGAGCTCGAGGACAATAT
GAGTGACCGGGTTCAGTTTGTGATCACAGCACAGGAATGGGATCCCAGCTTTGAGGAGGCCCTGATGGACAACCCCTCCCTGGCATTCGT
TCGTCCCCGATGGATCTACAGTTGCAATGAGAAGCAGAAGTTACTTCCTCACCAGCTCTATGGGGTGGTGCCGCAAGCCTGAAGTATGTG

>65931_65931_2_PLAUR-XRCC1_PLAUR_chr19_44156377_ENST00000221264_XRCC1_chr19_44050258_ENST00000543982_length(amino acids)=384AA_BP=1
MRPEGEKTCRDPAHRSCPRDMGHPPLLPLLLLLHTCVPASWGLRCMQCKTNGDCRVEECALGQDLCRTTIVRLWEEGEELELVEKSCTHS
EKTNRTLSYRTGLKITSLTEVVCGLDLCNQGNSGRAVTYSRSRYLECISCGSSDMSCERGRHQSLQCRSPEEQCLDVVTHWIQEGEEVLE
LENLPQNGRQCYSCKGNSTHGCSSEETFLIDCRGPMNQCLVATGTHEGQDNGAEDSGDTEDELRRVAEQKEHRLPPGQEENGEDPYAGST
DENTDSEEHQEPPDLPVPELPDFFQGKHFFLYGEFPGDERRKLIRYVTAFNGELEDNMSDRVQFVITAQEWDPSFEEALMDNPSLAFVRP

--------------------------------------------------------------
>65931_65931_3_PLAUR-XRCC1_PLAUR_chr19_44156377_ENST00000339082_XRCC1_chr19_44050258_ENST00000262887_length(transcript)=1628nt_BP=800nt
AGAGAAGACGTGCAGGGACCCCGCGCACAGGAGCTGCCCTCGCGACATGGGTCACCCGCCGCTGCTGCCGCTGCTGCTGCTGCTCCACAC
CTGCGTCCCAGCCTCTTGGGGCCTGCGGTGCATGCAGTGTAAGACCAACGGGGATTGCCGTGTGGAAGAGTGCGCCCTGGGACAGGACCT
CTGCAGGACCACGATCGTGCGCTTGTGGGAAGAAGGAGAAGAGCTGGAGCTGGTGGAGAAAAGCTGTACCCACTCAGAGAAGACCAACAG
GACCCTGAGCTATCGGACTGGCTTGAAGATCACCAGCCTTACCGAGGTTGTGTGTGGGTTAGACTTGTGCAACCAGGGCAACTCTGGCCG
GGCTGTCACCTATTCCCGAAGCCGTTACCTCGAATGCATTTCCTGTGGCTCATCAGACATGAGCTGTGAGAGGGGCCGGCACCAGAGCCT
GCAGTGCCGCAGCCCTGAAGAACAGTGCCTGGATGTGGTGACCCACTGGATCCAGGAAGGTGAAGAAGGGCGTCCAAAGGATGACCGCCA
CCTCCGTGGCTGTGGCTACCTTCCCGGCTGCCCGGGCTCCAATGGTTTCCACAACAACGACACCTTCCACTTCCTGAAATGCTGCAACAC
CACCAAATGCAACGAGGGCCCAATCCTGGAGCTTGAAAATCTGCCGCAGAATGGCCGCCAGTGTTACAGCTGCAAGGGGAACAGCACCCA
TGGATGCTCCTCTGAAGAGACTTTCCTCATTGACTGCCGAGGCCCCATGAATCAATGTCTGGTAGCCACCGGCACTCACGAAGGACAGGA
CAATGGGGCGGAAGATTCTGGGGACACAGAGGATGAGCTGAGGAGGGTGGCAGAGCAGAAGGAACACAGACTGCCCCCTGGCCAGGAGGA
GAATGGGGAAGACCCGTATGCAGGCTCCACGGATGAGAACACGGACAGTGAGGAACACCAGGAGCCTCCTGATCTGCCAGTCCCTGAGCT
CCCAGATTTCTTCCAGGGCAAGCACTTCTTTCTTTACGGGGAGTTCCCTGGGGACGAGCGGCGGAAACTCATCCGATACGTCACAGCCTT
CAATGGGGAGCTCGAGGACAATATGAGTGACCGGGTTCAGTTTGTGATCACAGCACAGGAATGGGATCCCAGCTTTGAGGAGGCCCTGAT
GGACAACCCCTCCCTGGCATTCGTTCGTCCCCGATGGATCTACAGTTGCAATGAGAAGCAGAAGTTACTTCCTCACCAGCTCTATGGGGT
GGTGCCGCAAGCCTGAAGTATGTGCTATACACACACACACACACACACACACACACACACACACACGATGCATTTAATAAAGATGAGTTG
GTTCTCATCCAAGAGTCTCCCAAAACTCTAAGAGGCTCCCTGGGACCTGGGGAAGAATGCTGGGCACCTCCGTCAGAGATCTGGTAGAGA
AGGAACTCTTTGTCTCTTCTGCTTGGCCCCTTATCCCTGTGTTGGCAAGAGGCAGGGAACTGGGAATCTGACCCTCAGCACTGCCCCTCA
ACTTTTTCTGGCCCTCTGAGCCACACCTGTATCTTGGCTGTCCCTTTGTGGCTGGAGGCCTGGGTACCCATGAGGCTTGTCTCTCTCCTG

>65931_65931_3_PLAUR-XRCC1_PLAUR_chr19_44156377_ENST00000339082_XRCC1_chr19_44050258_ENST00000262887_length(amino acids)=409AA_BP=0
MGHPPLLPLLLLLHTCVPASWGLRCMQCKTNGDCRVEECALGQDLCRTTIVRLWEEGEELELVEKSCTHSEKTNRTLSYRTGLKITSLTE
VVCGLDLCNQGNSGRAVTYSRSRYLECISCGSSDMSCERGRHQSLQCRSPEEQCLDVVTHWIQEGEEGRPKDDRHLRGCGYLPGCPGSNG
FHNNDTFHFLKCCNTTKCNEGPILELENLPQNGRQCYSCKGNSTHGCSSEETFLIDCRGPMNQCLVATGTHEGQDNGAEDSGDTEDELRR
VAEQKEHRLPPGQEENGEDPYAGSTDENTDSEEHQEPPDLPVPELPDFFQGKHFFLYGEFPGDERRKLIRYVTAFNGELEDNMSDRVQFV

--------------------------------------------------------------
>65931_65931_4_PLAUR-XRCC1_PLAUR_chr19_44156377_ENST00000339082_XRCC1_chr19_44050258_ENST00000543982_length(transcript)=1356nt_BP=800nt
AGAGAAGACGTGCAGGGACCCCGCGCACAGGAGCTGCCCTCGCGACATGGGTCACCCGCCGCTGCTGCCGCTGCTGCTGCTGCTCCACAC
CTGCGTCCCAGCCTCTTGGGGCCTGCGGTGCATGCAGTGTAAGACCAACGGGGATTGCCGTGTGGAAGAGTGCGCCCTGGGACAGGACCT
CTGCAGGACCACGATCGTGCGCTTGTGGGAAGAAGGAGAAGAGCTGGAGCTGGTGGAGAAAAGCTGTACCCACTCAGAGAAGACCAACAG
GACCCTGAGCTATCGGACTGGCTTGAAGATCACCAGCCTTACCGAGGTTGTGTGTGGGTTAGACTTGTGCAACCAGGGCAACTCTGGCCG
GGCTGTCACCTATTCCCGAAGCCGTTACCTCGAATGCATTTCCTGTGGCTCATCAGACATGAGCTGTGAGAGGGGCCGGCACCAGAGCCT
GCAGTGCCGCAGCCCTGAAGAACAGTGCCTGGATGTGGTGACCCACTGGATCCAGGAAGGTGAAGAAGGGCGTCCAAAGGATGACCGCCA
CCTCCGTGGCTGTGGCTACCTTCCCGGCTGCCCGGGCTCCAATGGTTTCCACAACAACGACACCTTCCACTTCCTGAAATGCTGCAACAC
CACCAAATGCAACGAGGGCCCAATCCTGGAGCTTGAAAATCTGCCGCAGAATGGCCGCCAGTGTTACAGCTGCAAGGGGAACAGCACCCA
TGGATGCTCCTCTGAAGAGACTTTCCTCATTGACTGCCGAGGCCCCATGAATCAATGTCTGGTAGCCACCGGCACTCACGAAGGACAGGA
CAATGGGGCGGAAGATTCTGGGGACACAGAGGATGAGCTGAGGAGGGTGGCAGAGCAGAAGGAACACAGACTGCCCCCTGGCCAGGAGGA
GAATGGGGAAGACCCGTATGCAGGCTCCACGGATGAGAACACGGACAGTGAGGAACACCAGGAGCCTCCTGATCTGCCAGTCCCTGAGCT
CCCAGATTTCTTCCAGGGCAAGCACTTCTTTCTTTACGGGGAGTTCCCTGGGGACGAGCGGCGGAAACTCATCCGATACGTCACAGCCTT
CAATGGGGAGCTCGAGGACAATATGAGTGACCGGGTTCAGTTTGTGATCACAGCACAGGAATGGGATCCCAGCTTTGAGGAGGCCCTGAT
GGACAACCCCTCCCTGGCATTCGTTCGTCCCCGATGGATCTACAGTTGCAATGAGAAGCAGAAGTTACTTCCTCACCAGCTCTATGGGGT
GGTGCCGCAAGCCTGAAGTATGTGCTATACACACACACACACACACACACACACACACACACACACGATGCATTTAATAAAGATGAGTTG

>65931_65931_4_PLAUR-XRCC1_PLAUR_chr19_44156377_ENST00000339082_XRCC1_chr19_44050258_ENST00000543982_length(amino acids)=409AA_BP=0
MGHPPLLPLLLLLHTCVPASWGLRCMQCKTNGDCRVEECALGQDLCRTTIVRLWEEGEELELVEKSCTHSEKTNRTLSYRTGLKITSLTE
VVCGLDLCNQGNSGRAVTYSRSRYLECISCGSSDMSCERGRHQSLQCRSPEEQCLDVVTHWIQEGEEGRPKDDRHLRGCGYLPGCPGSNG
FHNNDTFHFLKCCNTTKCNEGPILELENLPQNGRQCYSCKGNSTHGCSSEETFLIDCRGPMNQCLVATGTHEGQDNGAEDSGDTEDELRR
VAEQKEHRLPPGQEENGEDPYAGSTDENTDSEEHQEPPDLPVPELPDFFQGKHFFLYGEFPGDERRKLIRYVTAFNGELEDNMSDRVQFV

--------------------------------------------------------------
>65931_65931_5_PLAUR-XRCC1_PLAUR_chr19_44156377_ENST00000340093_XRCC1_chr19_44050258_ENST00000262887_length(transcript)=1812nt_BP=984nt
CAGGGCCGAGCCAGCCCCTTCACCACCAGCCGGCCGCGCCCCGGGAAGGGAAGTTTGTGGCGGAGGAGGTTCGTACGGGAGGAGGGGGAG
GCGCCCACGCATCTGGGGCTGACTCGCTCTTTCGCAAAACGTCTGGGAGGAGTCCCTGGGGCCACAAAACTGCCTCCTTCCTGAGGCCAG
AAGGAGAGAAGACGTGCAGGGACCCCGCGCACAGGAGCTGCCCTCGCGACATGGGTCACCCGCCGCTGCTGCCGCTGCTGCTGCTGCTCC
ACACCTGCGTCCCAGCCTCTTGGGGCCTGCGGTGCATGCAGTGTAAGACCAACGGGGATTGCCGTGTGGAAGAGTGCGCCCTGGGACAGG
ACCTCTGCAGGACCACGATCGTGCGCTTGTGGGAAGAAGGAGAAGAGCTGGAGCTGGTGGAGAAAAGCTGTACCCACTCAGAGAAGACCA
ACAGGACCCTGAGCTATCGGACTGGCTTGAAGATCACCAGCCTTACCGAGGTTGTGTGTGGGTTAGACTTGTGCAACCAGGGCAACTCTG
GCCGGGCTGTCACCTATTCCCGAAGCCGTTACCTCGAATGCATTTCCTGTGGCTCATCAGACATGAGCTGTGAGAGGGGCCGGCACCAGA
GCCTGCAGTGCCGCAGCCCTGAAGAACAGTGCCTGGATGTGGTGACCCACTGGATCCAGGAAGGTGAAGAAGGGCGTCCAAAGGATGACC
GCCACCTCCGTGGCTGTGGCTACCTTCCCGGCTGCCCGGGCTCCAATGGTTTCCACAACAACGACACCTTCCACTTCCTGAAATGCTGCA
ACACCACCAAATGCAACGAGGGCCCAATCCTGGAGCTTGAAAATCTGCCGCAGAATGGCCGCCAGTGTTACAGCTGCAAGGGGAACAGCA
CCCATGGATGCTCCTCTGAAGAGACTTTCCTCATTGACTGCCGAGGCCCCATGAATCAATGTCTGGTAGCCACCGGCACTCACGAAGGAC
AGGACAATGGGGCGGAAGATTCTGGGGACACAGAGGATGAGCTGAGGAGGGTGGCAGAGCAGAAGGAACACAGACTGCCCCCTGGCCAGG
AGGAGAATGGGGAAGACCCGTATGCAGGCTCCACGGATGAGAACACGGACAGTGAGGAACACCAGGAGCCTCCTGATCTGCCAGTCCCTG
AGCTCCCAGATTTCTTCCAGGGCAAGCACTTCTTTCTTTACGGGGAGTTCCCTGGGGACGAGCGGCGGAAACTCATCCGATACGTCACAG
CCTTCAATGGGGAGCTCGAGGACAATATGAGTGACCGGGTTCAGTTTGTGATCACAGCACAGGAATGGGATCCCAGCTTTGAGGAGGCCC
TGATGGACAACCCCTCCCTGGCATTCGTTCGTCCCCGATGGATCTACAGTTGCAATGAGAAGCAGAAGTTACTTCCTCACCAGCTCTATG
GGGTGGTGCCGCAAGCCTGAAGTATGTGCTATACACACACACACACACACACACACACACACACACACACGATGCATTTAATAAAGATGA
GTTGGTTCTCATCCAAGAGTCTCCCAAAACTCTAAGAGGCTCCCTGGGACCTGGGGAAGAATGCTGGGCACCTCCGTCAGAGATCTGGTA
GAGAAGGAACTCTTTGTCTCTTCTGCTTGGCCCCTTATCCCTGTGTTGGCAAGAGGCAGGGAACTGGGAATCTGACCCTCAGCACTGCCC
CTCAACTTTTTCTGGCCCTCTGAGCCACACCTGTATCTTGGCTGTCCCTTTGTGGCTGGAGGCCTGGGTACCCATGAGGCTTGTCTCTCT

>65931_65931_5_PLAUR-XRCC1_PLAUR_chr19_44156377_ENST00000340093_XRCC1_chr19_44050258_ENST00000262887_length(amino acids)=429AA_BP=1
MRPEGEKTCRDPAHRSCPRDMGHPPLLPLLLLLHTCVPASWGLRCMQCKTNGDCRVEECALGQDLCRTTIVRLWEEGEELELVEKSCTHS
EKTNRTLSYRTGLKITSLTEVVCGLDLCNQGNSGRAVTYSRSRYLECISCGSSDMSCERGRHQSLQCRSPEEQCLDVVTHWIQEGEEGRP
KDDRHLRGCGYLPGCPGSNGFHNNDTFHFLKCCNTTKCNEGPILELENLPQNGRQCYSCKGNSTHGCSSEETFLIDCRGPMNQCLVATGT
HEGQDNGAEDSGDTEDELRRVAEQKEHRLPPGQEENGEDPYAGSTDENTDSEEHQEPPDLPVPELPDFFQGKHFFLYGEFPGDERRKLIR

--------------------------------------------------------------
>65931_65931_6_PLAUR-XRCC1_PLAUR_chr19_44156377_ENST00000340093_XRCC1_chr19_44050258_ENST00000543982_length(transcript)=1540nt_BP=984nt
CAGGGCCGAGCCAGCCCCTTCACCACCAGCCGGCCGCGCCCCGGGAAGGGAAGTTTGTGGCGGAGGAGGTTCGTACGGGAGGAGGGGGAG
GCGCCCACGCATCTGGGGCTGACTCGCTCTTTCGCAAAACGTCTGGGAGGAGTCCCTGGGGCCACAAAACTGCCTCCTTCCTGAGGCCAG
AAGGAGAGAAGACGTGCAGGGACCCCGCGCACAGGAGCTGCCCTCGCGACATGGGTCACCCGCCGCTGCTGCCGCTGCTGCTGCTGCTCC
ACACCTGCGTCCCAGCCTCTTGGGGCCTGCGGTGCATGCAGTGTAAGACCAACGGGGATTGCCGTGTGGAAGAGTGCGCCCTGGGACAGG
ACCTCTGCAGGACCACGATCGTGCGCTTGTGGGAAGAAGGAGAAGAGCTGGAGCTGGTGGAGAAAAGCTGTACCCACTCAGAGAAGACCA
ACAGGACCCTGAGCTATCGGACTGGCTTGAAGATCACCAGCCTTACCGAGGTTGTGTGTGGGTTAGACTTGTGCAACCAGGGCAACTCTG
GCCGGGCTGTCACCTATTCCCGAAGCCGTTACCTCGAATGCATTTCCTGTGGCTCATCAGACATGAGCTGTGAGAGGGGCCGGCACCAGA
GCCTGCAGTGCCGCAGCCCTGAAGAACAGTGCCTGGATGTGGTGACCCACTGGATCCAGGAAGGTGAAGAAGGGCGTCCAAAGGATGACC
GCCACCTCCGTGGCTGTGGCTACCTTCCCGGCTGCCCGGGCTCCAATGGTTTCCACAACAACGACACCTTCCACTTCCTGAAATGCTGCA
ACACCACCAAATGCAACGAGGGCCCAATCCTGGAGCTTGAAAATCTGCCGCAGAATGGCCGCCAGTGTTACAGCTGCAAGGGGAACAGCA
CCCATGGATGCTCCTCTGAAGAGACTTTCCTCATTGACTGCCGAGGCCCCATGAATCAATGTCTGGTAGCCACCGGCACTCACGAAGGAC
AGGACAATGGGGCGGAAGATTCTGGGGACACAGAGGATGAGCTGAGGAGGGTGGCAGAGCAGAAGGAACACAGACTGCCCCCTGGCCAGG
AGGAGAATGGGGAAGACCCGTATGCAGGCTCCACGGATGAGAACACGGACAGTGAGGAACACCAGGAGCCTCCTGATCTGCCAGTCCCTG
AGCTCCCAGATTTCTTCCAGGGCAAGCACTTCTTTCTTTACGGGGAGTTCCCTGGGGACGAGCGGCGGAAACTCATCCGATACGTCACAG
CCTTCAATGGGGAGCTCGAGGACAATATGAGTGACCGGGTTCAGTTTGTGATCACAGCACAGGAATGGGATCCCAGCTTTGAGGAGGCCC
TGATGGACAACCCCTCCCTGGCATTCGTTCGTCCCCGATGGATCTACAGTTGCAATGAGAAGCAGAAGTTACTTCCTCACCAGCTCTATG
GGGTGGTGCCGCAAGCCTGAAGTATGTGCTATACACACACACACACACACACACACACACACACACACACGATGCATTTAATAAAGATGA

>65931_65931_6_PLAUR-XRCC1_PLAUR_chr19_44156377_ENST00000340093_XRCC1_chr19_44050258_ENST00000543982_length(amino acids)=429AA_BP=1
MRPEGEKTCRDPAHRSCPRDMGHPPLLPLLLLLHTCVPASWGLRCMQCKTNGDCRVEECALGQDLCRTTIVRLWEEGEELELVEKSCTHS
EKTNRTLSYRTGLKITSLTEVVCGLDLCNQGNSGRAVTYSRSRYLECISCGSSDMSCERGRHQSLQCRSPEEQCLDVVTHWIQEGEEGRP
KDDRHLRGCGYLPGCPGSNGFHNNDTFHFLKCCNTTKCNEGPILELENLPQNGRQCYSCKGNSTHGCSSEETFLIDCRGPMNQCLVATGT
HEGQDNGAEDSGDTEDELRRVAEQKEHRLPPGQEENGEDPYAGSTDENTDSEEHQEPPDLPVPELPDFFQGKHFFLYGEFPGDERRKLIR

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for PLAUR-XRCC1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for PLAUR-XRCC1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for PLAUR-XRCC1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source