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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PLB1-CAB39 (FusionGDB2 ID:65934)

Fusion Gene Summary for PLB1-CAB39

check button Fusion gene summary
Fusion gene informationFusion gene name: PLB1-CAB39
Fusion gene ID: 65934
HgeneTgene
Gene symbol

PLB1

CAB39

Gene ID

151056

51719

Gene namephospholipase B1calcium binding protein 39
SynonymsPLB|PLB/LIPCGI-66|MO25
Cytomap

2p23.2

2q37.1

Type of geneprotein-codingprotein-coding
Descriptionphospholipase B1, membrane-associatedlysophospholipasephospholipase A2phospholipase B/lipasecalcium-binding protein 39MO25alpha
Modification date2020031320200313
UniProtAcc.

Q9H9S4

Ensembl transtripts involved in fusion geneENST00000327757, ENST00000422425, 
ENST00000329020, ENST00000541605, 
ENST00000484398, ENST00000258418, 
ENST00000409788, ENST00000410084, 
Fusion gene scores* DoF score6 X 4 X 4=968 X 7 X 5=280
# samples 48
** MAII scorelog2(4/96*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/280*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PLB1 [Title/Abstract] AND CAB39 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPLB1(28742630)-CAB39(231678764), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCAB39

GO:0010800

positive regulation of peptidyl-threonine phosphorylation

24393035

TgeneCAB39

GO:0018105

peptidyl-serine phosphorylation

24393035

TgeneCAB39

GO:0023014

signal transduction by protein phosphorylation

24393035

TgeneCAB39

GO:0035556

intracellular signal transduction

24393035

TgeneCAB39

GO:0071902

positive regulation of protein serine/threonine kinase activity

19892943|24393035


check buttonFusion gene breakpoints across PLB1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CAB39 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-TK-A8OK-01APLB1chr2

28742630

-CAB39chr2

231678764

+


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Fusion Gene ORF analysis for PLB1-CAB39

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000327757ENST00000484398PLB1chr2

28742630

-CAB39chr2

231678764

+
5CDS-intronENST00000422425ENST00000484398PLB1chr2

28742630

-CAB39chr2

231678764

+
In-frameENST00000327757ENST00000258418PLB1chr2

28742630

-CAB39chr2

231678764

+
In-frameENST00000327757ENST00000409788PLB1chr2

28742630

-CAB39chr2

231678764

+
In-frameENST00000327757ENST00000410084PLB1chr2

28742630

-CAB39chr2

231678764

+
In-frameENST00000422425ENST00000258418PLB1chr2

28742630

-CAB39chr2

231678764

+
In-frameENST00000422425ENST00000409788PLB1chr2

28742630

-CAB39chr2

231678764

+
In-frameENST00000422425ENST00000410084PLB1chr2

28742630

-CAB39chr2

231678764

+
intron-3CDSENST00000329020ENST00000258418PLB1chr2

28742630

-CAB39chr2

231678764

+
intron-3CDSENST00000329020ENST00000409788PLB1chr2

28742630

-CAB39chr2

231678764

+
intron-3CDSENST00000329020ENST00000410084PLB1chr2

28742630

-CAB39chr2

231678764

+
intron-3CDSENST00000541605ENST00000258418PLB1chr2

28742630

-CAB39chr2

231678764

+
intron-3CDSENST00000541605ENST00000409788PLB1chr2

28742630

-CAB39chr2

231678764

+
intron-3CDSENST00000541605ENST00000410084PLB1chr2

28742630

-CAB39chr2

231678764

+
intron-intronENST00000329020ENST00000484398PLB1chr2

28742630

-CAB39chr2

231678764

+
intron-intronENST00000541605ENST00000484398PLB1chr2

28742630

-CAB39chr2

231678764

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000327757PLB1chr228742630-ENST00000258418CAB39chr2231678764+305728729685218
ENST00000327757PLB1chr228742630-ENST00000410084CAB39chr2231678764+68628729685219
ENST00000327757PLB1chr228742630-ENST00000409788CAB39chr2231678764+73228729685218
ENST00000422425PLB1chr228742630-ENST00000258418CAB39chr2231678764+305728729685218
ENST00000422425PLB1chr228742630-ENST00000410084CAB39chr2231678764+68628729685219
ENST00000422425PLB1chr228742630-ENST00000409788CAB39chr2231678764+73228729685218

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000327757ENST00000258418PLB1chr228742630-CAB39chr2231678764+0.0011902290.9988098
ENST00000327757ENST00000410084PLB1chr228742630-CAB39chr2231678764+0.0036015920.9963983
ENST00000327757ENST00000409788PLB1chr228742630-CAB39chr2231678764+0.002699140.9973009
ENST00000422425ENST00000258418PLB1chr228742630-CAB39chr2231678764+0.0011902290.9988098
ENST00000422425ENST00000410084PLB1chr228742630-CAB39chr2231678764+0.0036015920.9963983
ENST00000422425ENST00000409788PLB1chr228742630-CAB39chr2231678764+0.002699140.9973009

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Fusion Genomic Features for PLB1-CAB39


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PLB1-CAB39


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:28742630/chr2:231678764)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CAB39

Q9H9S4

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1 (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePLB1chr2:28742630chr2:231678764ENST00000327757-4581403_1445811459.0RegionNecessary for membrane localization
HgenePLB1chr2:28742630chr2:231678764ENST00000327757-45839_1402811459.0Region4 X 308-326 AA approximate repeats
HgenePLB1chr2:28742630chr2:231678764ENST00000329020-1211403_14450489.0RegionNecessary for membrane localization
HgenePLB1chr2:28742630chr2:231678764ENST00000329020-12139_14020489.0Region4 X 308-326 AA approximate repeats
HgenePLB1chr2:28742630chr2:231678764ENST00000422425-4571403_1445811448.0RegionNecessary for membrane localization
HgenePLB1chr2:28742630chr2:231678764ENST00000422425-45739_1402811448.0Region4 X 308-326 AA approximate repeats
HgenePLB1chr2:28742630chr2:231678764ENST00000541605-1181403_14450424.0RegionNecessary for membrane localization
HgenePLB1chr2:28742630chr2:231678764ENST00000541605-11839_14020424.0Region4 X 308-326 AA approximate repeats
HgenePLB1chr2:28742630chr2:231678764ENST00000327757-4581064_1402811459.0Repeat4
HgenePLB1chr2:28742630chr2:231678764ENST00000327757-458362_707811459.0Repeat2
HgenePLB1chr2:28742630chr2:231678764ENST00000327757-45839_347811459.0Repeat1
HgenePLB1chr2:28742630chr2:231678764ENST00000327757-458708_1054811459.0Repeat3
HgenePLB1chr2:28742630chr2:231678764ENST00000329020-1211064_14020489.0Repeat4
HgenePLB1chr2:28742630chr2:231678764ENST00000329020-121362_7070489.0Repeat2
HgenePLB1chr2:28742630chr2:231678764ENST00000329020-12139_3470489.0Repeat1
HgenePLB1chr2:28742630chr2:231678764ENST00000329020-121708_10540489.0Repeat3
HgenePLB1chr2:28742630chr2:231678764ENST00000422425-4571064_1402811448.0Repeat4
HgenePLB1chr2:28742630chr2:231678764ENST00000422425-457362_707811448.0Repeat2
HgenePLB1chr2:28742630chr2:231678764ENST00000422425-45739_347811448.0Repeat1
HgenePLB1chr2:28742630chr2:231678764ENST00000422425-457708_1054811448.0Repeat3
HgenePLB1chr2:28742630chr2:231678764ENST00000541605-1181064_14020424.0Repeat4
HgenePLB1chr2:28742630chr2:231678764ENST00000541605-118362_7070424.0Repeat2
HgenePLB1chr2:28742630chr2:231678764ENST00000541605-11839_3470424.0Repeat1
HgenePLB1chr2:28742630chr2:231678764ENST00000541605-118708_10540424.0Repeat3
HgenePLB1chr2:28742630chr2:231678764ENST00000327757-4581439_1458811459.0Topological domainCytoplasmic
HgenePLB1chr2:28742630chr2:231678764ENST00000327757-45822_1417811459.0Topological domainExtracellular
HgenePLB1chr2:28742630chr2:231678764ENST00000329020-1211439_14580489.0Topological domainCytoplasmic
HgenePLB1chr2:28742630chr2:231678764ENST00000329020-12122_14170489.0Topological domainExtracellular
HgenePLB1chr2:28742630chr2:231678764ENST00000422425-4571439_1458811448.0Topological domainCytoplasmic
HgenePLB1chr2:28742630chr2:231678764ENST00000422425-45722_1417811448.0Topological domainExtracellular
HgenePLB1chr2:28742630chr2:231678764ENST00000541605-1181439_14580424.0Topological domainCytoplasmic
HgenePLB1chr2:28742630chr2:231678764ENST00000541605-11822_14170424.0Topological domainExtracellular
HgenePLB1chr2:28742630chr2:231678764ENST00000327757-4581418_1438811459.0TransmembraneHelical
HgenePLB1chr2:28742630chr2:231678764ENST00000329020-1211418_14380489.0TransmembraneHelical
HgenePLB1chr2:28742630chr2:231678764ENST00000422425-4571418_1438811448.0TransmembraneHelical
HgenePLB1chr2:28742630chr2:231678764ENST00000541605-1181418_14380424.0TransmembraneHelical


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Fusion Gene Sequence for PLB1-CAB39


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>65934_65934_1_PLB1-CAB39_PLB1_chr2_28742630_ENST00000327757_CAB39_chr2_231678764_ENST00000258418_length(transcript)=3057nt_BP=287nt
GGAGCAGCTCTTCCAGAGGCCCGAGTCACCTGGAGCATTCTGGCATGGGGCTGCGGCCAGGCATTTTCCTCCTGGAGCTGCTGCTGCTTC
TGGGGCAAGGGACCCCTCAGATCCATACCTCTCCTAGAAAGAGTACATTGGAAGGGCAGCTATGGCCAGAGACCCTGAAGAATTCTCCAT
TCCCATGCAACCCAAATAAATTAGGAGTGAATATGCCTTCTAAATCAGTTCACTCTCTGAAGCCTTCTGATATTAAATTTGTGGCAGCCA
TTGGCAATCTGGAAATTTTTTTCAGTGAATATGAGAAGTTACTTCATTCAGAAAATTATGTGACAAAAAGACAGTCACTGAAGCTTCTCG
GTGAACTACTACTAGATAGACACAACTTCACAATTATGACAAAATACATCAGTAAACCTGAGAACCTCAAATTAATGATGAACCTGCTGC
GAGACAAAAGTCGCAACATCCAGTTTGAGGCCTTTCACGTTTTTAAGGTGTTTGTAGCCAATCCTAACAAGACGCAGCCCATCCTAGACA
TCCTCCTCAAGAACCAGGCCAAACTCATAGAGTTCCTCAGCAAGTTTCAGAACGACAGGACGGAGGATGAGCAGTTTAACGACGAGAAGA
CCTATTTAGTTAAACAGATCAGGGATTTGAAGAGACCAGCTCAGCAAGAAGCTTAATCTCCAATAAACATCTATGTTAAATCCAAATTCA
GCATTTGCTGTTAGCTATTCAGCATCAGGCACTCTTATTGATTCATGAGGAACATTACTGCTAATCTGCTGTTAAGTGAACGGTTTTTCA
TTTTACCCTTTTGTTTTTCAGTCCAGGTTGGAGATCGTAGCTGCTGCTGCTTGCACACTAGGGCACATGTGGGCTTTCTCTTGATCTTTG
TGTCATTTCAGAATTCAAAGACTGTGCTACGGGAGTTCTGAACATGGCTGGGTTCATGAAGGCAAATGTATGGATGAGAGTGTGGTTTAG
GAAAGAGGGCACTGATATCAGATTAGACCTATGTGTTTGCACCCATCTTTGTTGGCGATCTGAGTGCAGTGTGGCAAGTGCACACCTGGC
ATCCCTGCGTCAGATCGCGCACCTTCAGGTCGCGCACCTTCGCTGAAGGAAGATGACGCAGAGCTTTATCTGAAATCAGAGGGGAGCTAT
CCAAAATGGGAGTTTGGGGGCAGCTAAAGTTGACATGCGAATAAATTGATACTGAAACTTAGCAACTTCTTAAAAGTGTAAAGAAGCCTC
ATAAGATCATAAGGAAAATGTATATATGCTTTTCACAGCTTTCTAGAATTTTTTGACATTTGATTTTCTTGAGACTTGTAAACCTGGATA
TGTTGAAGGGTATTTGTTAATTTTACTTTTCAAAGATACTTTAAAACAGTAGAGCTAGCAATGACACCTTGCATTTCATTTCAACACTGC
TTCAAGGTTTCTTTTGTATATAATTCTTAGAATGCTCATTTCTTTTAAATGGTTTAATTTGTACAGCAGAGGAATGTTATTGTAGTAGTA
TGTAACTATTACCTAATACTGAGTTTTTGCAAAAAACAATGAATGCTCATATGTAATTGAAATACTTCAGATCACATGAAAATGCTGATT
TAACATTTAAGTATCACAGCATTAAAAGAAAAAGAAAGTAAACCAGTCCTTTGTATTCAGTTACCTAATGGGGTGCCATCAATAAGCTGC
GATACAGCCCTGGAGCTCAGTCAGCCACACCTTCCTGCATCCTATTGGCCTTATTCATTTTAAATGAGTTAATGAATCTGCCAGATCTGT
GAATGATAGAGATTATGCTAAATTAATGCTGATTCTTTGTGTGTGTGGGAAATCTCTGTAGAGCACCTTTTCTTTCTTAGACTAAGTAAC
CCAGTACAATAGTTGTGAACTGAATAATTAAAACTTTGGCTTCTCTTAGGAAAAGACGACTTCCTAGTCATAGGTGTCCTATGGGGAAAT
TTATTTTTTTTAATGTCCTGTTCCTTAATGCTGCAAATTATCAGTATTTATAAAGTAACTGATTTTGCACCACTTTTTTGTTACTGTGAC
CACGGCAGAACAATGTCTTCTAGACTATATCTATGTAAAGTTATTAGAATGGTATCTGTTCATTTTAGTGATATGAAGATCACAACTAAC
AACTGACAAATCAGAGTTTGCCAGTTCAAATTCAGCATGGCTGCAGCTGATTAAGAAATTGATATGATTATTCTTTGCTAGCCTCTCTTA
CTAATGGAATTATATACTGGCCAGTAAAATGGGCCTCCCAATTGCTGTTTCAGCAGGTTTTAAACCTTCAGGAACACCAGTTAGGAAAAT
AGCTCCAGAAAATATAGATATATTTTATTTTTATTAAAATGGCAGTCTACATCATAATTGGCATTTCTCAAGACTGTCTTTACCAGAATC
TGTGTGAAATAAGGCAATCTAGTCTCCTTGAAAAAAAAATCTCTTGGATGTTTAGGAAGGAAGACTTGGCCGTGATGTGGTGTCCTGGCT
TTGTGGTGTAGTGCTGTGTGTATGGAGTTAGTGTAAAAACATGGATTACACCAAGTGGAAGAAACGTCTTCTTGCCAAGCTCATTCTTAG
AACTTACACATCTAGAACAGCTTCCACTTTGGCAGTGAGGTCGTAGCCTTTTAGGTGGAAGAAGTGAGGGTGCAGCGTGTCAGACACAAC
ATTCATGTTACTCTTACATTGGAATCTGAAGGTAGTTCAGACTTCGTGGGTTTTGTTTTTAAGCAAAACAATGTGAAAACATTTAAGTTT
GAAATGTTGCATTTGAAGTTATGATCATTTAATATATTCATATTACCAAGACTATTATACTGGAAGTGGTTTTTGTGTTATAAAGGTTTA
ATTTTACATAAGGCAGTTACTTAATGTGATTTTTAACCCTTAAAAAAGTGGAGATGTATACATTTGTTAACAATGCCATGAAAGCATTTT

>65934_65934_1_PLB1-CAB39_PLB1_chr2_28742630_ENST00000327757_CAB39_chr2_231678764_ENST00000258418_length(amino acids)=218AA_BP=86
MEHSGMGLRPGIFLLELLLLLGQGTPQIHTSPRKSTLEGQLWPETLKNSPFPCNPNKLGVNMPSKSVHSLKPSDIKFVAAIGNLEIFFSE
YEKLLHSENYVTKRQSLKLLGELLLDRHNFTIMTKYISKPENLKLMMNLLRDKSRNIQFEAFHVFKVFVANPNKTQPILDILLKNQAKLI

--------------------------------------------------------------
>65934_65934_2_PLB1-CAB39_PLB1_chr2_28742630_ENST00000327757_CAB39_chr2_231678764_ENST00000409788_length(transcript)=732nt_BP=287nt
GGAGCAGCTCTTCCAGAGGCCCGAGTCACCTGGAGCATTCTGGCATGGGGCTGCGGCCAGGCATTTTCCTCCTGGAGCTGCTGCTGCTTC
TGGGGCAAGGGACCCCTCAGATCCATACCTCTCCTAGAAAGAGTACATTGGAAGGGCAGCTATGGCCAGAGACCCTGAAGAATTCTCCAT
TCCCATGCAACCCAAATAAATTAGGAGTGAATATGCCTTCTAAATCAGTTCACTCTCTGAAGCCTTCTGATATTAAATTTGTGGCAGCCA
TTGGCAATCTGGAAATTTTTTTCAGTGAATATGAGAAGTTACTTCATTCAGAAAATTATGTGACAAAAAGACAGTCACTGAAGCTTCTCG
GTGAACTACTACTAGATAGACACAACTTCACAATTATGACAAAATACATCAGTAAACCTGAGAACCTCAAATTAATGATGAACCTGCTGC
GAGACAAAAGTCGCAACATCCAGTTTGAGGCCTTTCACGTTTTTAAGGTGTTTGTAGCCAATCCTAACAAGACGCAGCCCATCCTAGACA
TCCTCCTCAAGAACCAGGCCAAACTCATAGAGTTCCTCAGCAAGTTTCAGAACGACAGGACGGAGGATGAGCAGTTTAACGACGAGAAGA
CCTATTTAGTTAAACAGATCAGGGATTTGAAGAGACCAGCTCAGCAAGAAGCTTAATCTCCAATAAACATCTATGTTAAATCCAAATTCA

>65934_65934_2_PLB1-CAB39_PLB1_chr2_28742630_ENST00000327757_CAB39_chr2_231678764_ENST00000409788_length(amino acids)=218AA_BP=86
MEHSGMGLRPGIFLLELLLLLGQGTPQIHTSPRKSTLEGQLWPETLKNSPFPCNPNKLGVNMPSKSVHSLKPSDIKFVAAIGNLEIFFSE
YEKLLHSENYVTKRQSLKLLGELLLDRHNFTIMTKYISKPENLKLMMNLLRDKSRNIQFEAFHVFKVFVANPNKTQPILDILLKNQAKLI

--------------------------------------------------------------
>65934_65934_3_PLB1-CAB39_PLB1_chr2_28742630_ENST00000327757_CAB39_chr2_231678764_ENST00000410084_length(transcript)=686nt_BP=287nt
GGAGCAGCTCTTCCAGAGGCCCGAGTCACCTGGAGCATTCTGGCATGGGGCTGCGGCCAGGCATTTTCCTCCTGGAGCTGCTGCTGCTTC
TGGGGCAAGGGACCCCTCAGATCCATACCTCTCCTAGAAAGAGTACATTGGAAGGGCAGCTATGGCCAGAGACCCTGAAGAATTCTCCAT
TCCCATGCAACCCAAATAAATTAGGAGTGAATATGCCTTCTAAATCAGTTCACTCTCTGAAGCCTTCTGATATTAAATTTGTGGCAGCCA
TTGGCAATCTGGAAATTTTTTTCAGTGAATATGAGAAGTTACTTCATTCAGAAAATTATGTGACAAAAAGACAGTCACTGAAGCTTCTCG
GTGAACTACTACTAGATAGACACAACTTCACAATTATGACAAAATACATCAGTAAACCTGAGAACCTCAAATTAATGATGAACCTGCTGC
GAGACAAAAGTCGCAACATCCAGTTTGAGGCCTTTCACGTTTTTAAGGTGTTTGTAGCCAATCCTAACAAGACGCAGCCCATCCTAGACA
TCCTCCTCAAGAACCAGGCCAAACTCATAGAGTTCCTCAGCAAGTTTCAGAACGACAGGACGGAGGATGAGCAGTTTAACGACGAGAAGA

>65934_65934_3_PLB1-CAB39_PLB1_chr2_28742630_ENST00000327757_CAB39_chr2_231678764_ENST00000410084_length(amino acids)=219AA_BP=86
MEHSGMGLRPGIFLLELLLLLGQGTPQIHTSPRKSTLEGQLWPETLKNSPFPCNPNKLGVNMPSKSVHSLKPSDIKFVAAIGNLEIFFSE
YEKLLHSENYVTKRQSLKLLGELLLDRHNFTIMTKYISKPENLKLMMNLLRDKSRNIQFEAFHVFKVFVANPNKTQPILDILLKNQAKLI

--------------------------------------------------------------
>65934_65934_4_PLB1-CAB39_PLB1_chr2_28742630_ENST00000422425_CAB39_chr2_231678764_ENST00000258418_length(transcript)=3057nt_BP=287nt
GGAGCAGCTCTTCCAGAGGCCCGAGTCACCTGGAGCATTCTGGCATGGGGCTGCGGCCAGGCATTTTCCTCCTGGAGCTGCTGCTGCTTC
TGGGGCAAGGGACCCCTCAGATCCATACCTCTCCTAGAAAGAGTACATTGGAAGGGCAGCTATGGCCAGAGACCCTGAAGAATTCTCCAT
TCCCATGCAACCCAAATAAATTAGGAGTGAATATGCCTTCTAAATCAGTTCACTCTCTGAAGCCTTCTGATATTAAATTTGTGGCAGCCA
TTGGCAATCTGGAAATTTTTTTCAGTGAATATGAGAAGTTACTTCATTCAGAAAATTATGTGACAAAAAGACAGTCACTGAAGCTTCTCG
GTGAACTACTACTAGATAGACACAACTTCACAATTATGACAAAATACATCAGTAAACCTGAGAACCTCAAATTAATGATGAACCTGCTGC
GAGACAAAAGTCGCAACATCCAGTTTGAGGCCTTTCACGTTTTTAAGGTGTTTGTAGCCAATCCTAACAAGACGCAGCCCATCCTAGACA
TCCTCCTCAAGAACCAGGCCAAACTCATAGAGTTCCTCAGCAAGTTTCAGAACGACAGGACGGAGGATGAGCAGTTTAACGACGAGAAGA
CCTATTTAGTTAAACAGATCAGGGATTTGAAGAGACCAGCTCAGCAAGAAGCTTAATCTCCAATAAACATCTATGTTAAATCCAAATTCA
GCATTTGCTGTTAGCTATTCAGCATCAGGCACTCTTATTGATTCATGAGGAACATTACTGCTAATCTGCTGTTAAGTGAACGGTTTTTCA
TTTTACCCTTTTGTTTTTCAGTCCAGGTTGGAGATCGTAGCTGCTGCTGCTTGCACACTAGGGCACATGTGGGCTTTCTCTTGATCTTTG
TGTCATTTCAGAATTCAAAGACTGTGCTACGGGAGTTCTGAACATGGCTGGGTTCATGAAGGCAAATGTATGGATGAGAGTGTGGTTTAG
GAAAGAGGGCACTGATATCAGATTAGACCTATGTGTTTGCACCCATCTTTGTTGGCGATCTGAGTGCAGTGTGGCAAGTGCACACCTGGC
ATCCCTGCGTCAGATCGCGCACCTTCAGGTCGCGCACCTTCGCTGAAGGAAGATGACGCAGAGCTTTATCTGAAATCAGAGGGGAGCTAT
CCAAAATGGGAGTTTGGGGGCAGCTAAAGTTGACATGCGAATAAATTGATACTGAAACTTAGCAACTTCTTAAAAGTGTAAAGAAGCCTC
ATAAGATCATAAGGAAAATGTATATATGCTTTTCACAGCTTTCTAGAATTTTTTGACATTTGATTTTCTTGAGACTTGTAAACCTGGATA
TGTTGAAGGGTATTTGTTAATTTTACTTTTCAAAGATACTTTAAAACAGTAGAGCTAGCAATGACACCTTGCATTTCATTTCAACACTGC
TTCAAGGTTTCTTTTGTATATAATTCTTAGAATGCTCATTTCTTTTAAATGGTTTAATTTGTACAGCAGAGGAATGTTATTGTAGTAGTA
TGTAACTATTACCTAATACTGAGTTTTTGCAAAAAACAATGAATGCTCATATGTAATTGAAATACTTCAGATCACATGAAAATGCTGATT
TAACATTTAAGTATCACAGCATTAAAAGAAAAAGAAAGTAAACCAGTCCTTTGTATTCAGTTACCTAATGGGGTGCCATCAATAAGCTGC
GATACAGCCCTGGAGCTCAGTCAGCCACACCTTCCTGCATCCTATTGGCCTTATTCATTTTAAATGAGTTAATGAATCTGCCAGATCTGT
GAATGATAGAGATTATGCTAAATTAATGCTGATTCTTTGTGTGTGTGGGAAATCTCTGTAGAGCACCTTTTCTTTCTTAGACTAAGTAAC
CCAGTACAATAGTTGTGAACTGAATAATTAAAACTTTGGCTTCTCTTAGGAAAAGACGACTTCCTAGTCATAGGTGTCCTATGGGGAAAT
TTATTTTTTTTAATGTCCTGTTCCTTAATGCTGCAAATTATCAGTATTTATAAAGTAACTGATTTTGCACCACTTTTTTGTTACTGTGAC
CACGGCAGAACAATGTCTTCTAGACTATATCTATGTAAAGTTATTAGAATGGTATCTGTTCATTTTAGTGATATGAAGATCACAACTAAC
AACTGACAAATCAGAGTTTGCCAGTTCAAATTCAGCATGGCTGCAGCTGATTAAGAAATTGATATGATTATTCTTTGCTAGCCTCTCTTA
CTAATGGAATTATATACTGGCCAGTAAAATGGGCCTCCCAATTGCTGTTTCAGCAGGTTTTAAACCTTCAGGAACACCAGTTAGGAAAAT
AGCTCCAGAAAATATAGATATATTTTATTTTTATTAAAATGGCAGTCTACATCATAATTGGCATTTCTCAAGACTGTCTTTACCAGAATC
TGTGTGAAATAAGGCAATCTAGTCTCCTTGAAAAAAAAATCTCTTGGATGTTTAGGAAGGAAGACTTGGCCGTGATGTGGTGTCCTGGCT
TTGTGGTGTAGTGCTGTGTGTATGGAGTTAGTGTAAAAACATGGATTACACCAAGTGGAAGAAACGTCTTCTTGCCAAGCTCATTCTTAG
AACTTACACATCTAGAACAGCTTCCACTTTGGCAGTGAGGTCGTAGCCTTTTAGGTGGAAGAAGTGAGGGTGCAGCGTGTCAGACACAAC
ATTCATGTTACTCTTACATTGGAATCTGAAGGTAGTTCAGACTTCGTGGGTTTTGTTTTTAAGCAAAACAATGTGAAAACATTTAAGTTT
GAAATGTTGCATTTGAAGTTATGATCATTTAATATATTCATATTACCAAGACTATTATACTGGAAGTGGTTTTTGTGTTATAAAGGTTTA
ATTTTACATAAGGCAGTTACTTAATGTGATTTTTAACCCTTAAAAAAGTGGAGATGTATACATTTGTTAACAATGCCATGAAAGCATTTT

>65934_65934_4_PLB1-CAB39_PLB1_chr2_28742630_ENST00000422425_CAB39_chr2_231678764_ENST00000258418_length(amino acids)=218AA_BP=86
MEHSGMGLRPGIFLLELLLLLGQGTPQIHTSPRKSTLEGQLWPETLKNSPFPCNPNKLGVNMPSKSVHSLKPSDIKFVAAIGNLEIFFSE
YEKLLHSENYVTKRQSLKLLGELLLDRHNFTIMTKYISKPENLKLMMNLLRDKSRNIQFEAFHVFKVFVANPNKTQPILDILLKNQAKLI

--------------------------------------------------------------
>65934_65934_5_PLB1-CAB39_PLB1_chr2_28742630_ENST00000422425_CAB39_chr2_231678764_ENST00000409788_length(transcript)=732nt_BP=287nt
GGAGCAGCTCTTCCAGAGGCCCGAGTCACCTGGAGCATTCTGGCATGGGGCTGCGGCCAGGCATTTTCCTCCTGGAGCTGCTGCTGCTTC
TGGGGCAAGGGACCCCTCAGATCCATACCTCTCCTAGAAAGAGTACATTGGAAGGGCAGCTATGGCCAGAGACCCTGAAGAATTCTCCAT
TCCCATGCAACCCAAATAAATTAGGAGTGAATATGCCTTCTAAATCAGTTCACTCTCTGAAGCCTTCTGATATTAAATTTGTGGCAGCCA
TTGGCAATCTGGAAATTTTTTTCAGTGAATATGAGAAGTTACTTCATTCAGAAAATTATGTGACAAAAAGACAGTCACTGAAGCTTCTCG
GTGAACTACTACTAGATAGACACAACTTCACAATTATGACAAAATACATCAGTAAACCTGAGAACCTCAAATTAATGATGAACCTGCTGC
GAGACAAAAGTCGCAACATCCAGTTTGAGGCCTTTCACGTTTTTAAGGTGTTTGTAGCCAATCCTAACAAGACGCAGCCCATCCTAGACA
TCCTCCTCAAGAACCAGGCCAAACTCATAGAGTTCCTCAGCAAGTTTCAGAACGACAGGACGGAGGATGAGCAGTTTAACGACGAGAAGA
CCTATTTAGTTAAACAGATCAGGGATTTGAAGAGACCAGCTCAGCAAGAAGCTTAATCTCCAATAAACATCTATGTTAAATCCAAATTCA

>65934_65934_5_PLB1-CAB39_PLB1_chr2_28742630_ENST00000422425_CAB39_chr2_231678764_ENST00000409788_length(amino acids)=218AA_BP=86
MEHSGMGLRPGIFLLELLLLLGQGTPQIHTSPRKSTLEGQLWPETLKNSPFPCNPNKLGVNMPSKSVHSLKPSDIKFVAAIGNLEIFFSE
YEKLLHSENYVTKRQSLKLLGELLLDRHNFTIMTKYISKPENLKLMMNLLRDKSRNIQFEAFHVFKVFVANPNKTQPILDILLKNQAKLI

--------------------------------------------------------------
>65934_65934_6_PLB1-CAB39_PLB1_chr2_28742630_ENST00000422425_CAB39_chr2_231678764_ENST00000410084_length(transcript)=686nt_BP=287nt
GGAGCAGCTCTTCCAGAGGCCCGAGTCACCTGGAGCATTCTGGCATGGGGCTGCGGCCAGGCATTTTCCTCCTGGAGCTGCTGCTGCTTC
TGGGGCAAGGGACCCCTCAGATCCATACCTCTCCTAGAAAGAGTACATTGGAAGGGCAGCTATGGCCAGAGACCCTGAAGAATTCTCCAT
TCCCATGCAACCCAAATAAATTAGGAGTGAATATGCCTTCTAAATCAGTTCACTCTCTGAAGCCTTCTGATATTAAATTTGTGGCAGCCA
TTGGCAATCTGGAAATTTTTTTCAGTGAATATGAGAAGTTACTTCATTCAGAAAATTATGTGACAAAAAGACAGTCACTGAAGCTTCTCG
GTGAACTACTACTAGATAGACACAACTTCACAATTATGACAAAATACATCAGTAAACCTGAGAACCTCAAATTAATGATGAACCTGCTGC
GAGACAAAAGTCGCAACATCCAGTTTGAGGCCTTTCACGTTTTTAAGGTGTTTGTAGCCAATCCTAACAAGACGCAGCCCATCCTAGACA
TCCTCCTCAAGAACCAGGCCAAACTCATAGAGTTCCTCAGCAAGTTTCAGAACGACAGGACGGAGGATGAGCAGTTTAACGACGAGAAGA

>65934_65934_6_PLB1-CAB39_PLB1_chr2_28742630_ENST00000422425_CAB39_chr2_231678764_ENST00000410084_length(amino acids)=219AA_BP=86
MEHSGMGLRPGIFLLELLLLLGQGTPQIHTSPRKSTLEGQLWPETLKNSPFPCNPNKLGVNMPSKSVHSLKPSDIKFVAAIGNLEIFFSE
YEKLLHSENYVTKRQSLKLLGELLLDRHNFTIMTKYISKPENLKLMMNLLRDKSRNIQFEAFHVFKVFVANPNKTQPILDILLKNQAKLI

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PLB1-CAB39


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PLB1-CAB39


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PLB1-CAB39


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource