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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PLB1-PPP1CB (FusionGDB2 ID:65940)

Fusion Gene Summary for PLB1-PPP1CB

check button Fusion gene summary
Fusion gene informationFusion gene name: PLB1-PPP1CB
Fusion gene ID: 65940
HgeneTgene
Gene symbol

PLB1

PPP1CB

Gene ID

151056

5500

Gene namephospholipase B1protein phosphatase 1 catalytic subunit beta
SynonymsPLB|PLB/LIPHEL-S-80p|MP|NSLH2|PP-1B|PP1B|PP1beta|PP1c|PPP1CD|PPP1beta
Cytomap

2p23.2

2p23.2

Type of geneprotein-codingprotein-coding
Descriptionphospholipase B1, membrane-associatedlysophospholipasephospholipase A2phospholipase B/lipaseserine/threonine-protein phosphatase PP1-beta catalytic subunitepididymis secretory sperm binding protein Li 80pmyosin phosphataseprotein phosphatase 1, catalytic subunit, beta isoformprotein phosphatase 1, catalytic subunit, beta isozymeprotein phos
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000327757, ENST00000422425, 
ENST00000329020, ENST00000541605, 
ENST00000296122, ENST00000358506, 
ENST00000395366, 
Fusion gene scores* DoF score6 X 4 X 4=9615 X 15 X 7=1575
# samples 417
** MAII scorelog2(4/96*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/1575*10)=-3.21174517713694
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PLB1 [Title/Abstract] AND PPP1CB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPPP1CB(28975042)-PLB1(28804935), # samples:2
PPP1CB(28975042)-PLB1(28785908), # samples:2
PPP1CB(28999848)-PLB1(28796064), # samples:2
PPP1CB(29006844)-PLB1(28820872), # samples:2
PLB1(28719036)-PPP1CB(28999716), # samples:1
Anticipated loss of major functional domain due to fusion event.PPP1CB-PLB1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePPP1CB

GO:0030155

regulation of cell adhesion

20354225


check buttonFusion gene breakpoints across PLB1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PPP1CB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-36-1581PLB1chr2

28719036

+PPP1CBchr2

28999716

+


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Fusion Gene ORF analysis for PLB1-PPP1CB

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000327757ENST00000296122PLB1chr2

28719036

+PPP1CBchr2

28999716

+
In-frameENST00000327757ENST00000358506PLB1chr2

28719036

+PPP1CBchr2

28999716

+
In-frameENST00000327757ENST00000395366PLB1chr2

28719036

+PPP1CBchr2

28999716

+
In-frameENST00000422425ENST00000296122PLB1chr2

28719036

+PPP1CBchr2

28999716

+
In-frameENST00000422425ENST00000358506PLB1chr2

28719036

+PPP1CBchr2

28999716

+
In-frameENST00000422425ENST00000395366PLB1chr2

28719036

+PPP1CBchr2

28999716

+
intron-3CDSENST00000329020ENST00000296122PLB1chr2

28719036

+PPP1CBchr2

28999716

+
intron-3CDSENST00000329020ENST00000358506PLB1chr2

28719036

+PPP1CBchr2

28999716

+
intron-3CDSENST00000329020ENST00000395366PLB1chr2

28719036

+PPP1CBchr2

28999716

+
intron-3CDSENST00000541605ENST00000296122PLB1chr2

28719036

+PPP1CBchr2

28999716

+
intron-3CDSENST00000541605ENST00000358506PLB1chr2

28719036

+PPP1CBchr2

28999716

+
intron-3CDSENST00000541605ENST00000395366PLB1chr2

28719036

+PPP1CBchr2

28999716

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000327757PLB1chr228719036+ENST00000358506PPP1CBchr228999716+465899291030333
ENST00000327757PLB1chr228719036+ENST00000296122PPP1CBchr228999716+337699291030333
ENST00000327757PLB1chr228719036+ENST00000395366PPP1CBchr228999716+466899291030333
ENST00000422425PLB1chr228719036+ENST00000358506PPP1CBchr228999716+465899291030333
ENST00000422425PLB1chr228719036+ENST00000296122PPP1CBchr228999716+337699291030333
ENST00000422425PLB1chr228719036+ENST00000395366PPP1CBchr228999716+466899291030333

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000327757ENST00000358506PLB1chr228719036+PPP1CBchr228999716+0.0001034810.9998965
ENST00000327757ENST00000296122PLB1chr228719036+PPP1CBchr228999716+0.0001109240.999889
ENST00000327757ENST00000395366PLB1chr228719036+PPP1CBchr228999716+0.0001078450.9998921
ENST00000422425ENST00000358506PLB1chr228719036+PPP1CBchr228999716+0.0001034810.9998965
ENST00000422425ENST00000296122PLB1chr228719036+PPP1CBchr228999716+0.0001109240.999889
ENST00000422425ENST00000395366PLB1chr228719036+PPP1CBchr228999716+0.0001078450.9998921

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Fusion Genomic Features for PLB1-PPP1CB


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PLB1chr228719036+PPP1CBchr228999716+1.49E-060.99999857
PLB1chr228719036+PPP1CBchr228999716+1.49E-060.99999857

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PLB1-PPP1CB


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:28975042/chr2:28804935)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePLB1chr2:28719036chr2:28999716ENST00000327757+1581403_1445181459.0RegionNecessary for membrane localization
HgenePLB1chr2:28719036chr2:28999716ENST00000327757+15839_1402181459.0Region4 X 308-326 AA approximate repeats
HgenePLB1chr2:28719036chr2:28999716ENST00000329020+1211403_14450489.0RegionNecessary for membrane localization
HgenePLB1chr2:28719036chr2:28999716ENST00000329020+12139_14020489.0Region4 X 308-326 AA approximate repeats
HgenePLB1chr2:28719036chr2:28999716ENST00000422425+1571403_1445181448.0RegionNecessary for membrane localization
HgenePLB1chr2:28719036chr2:28999716ENST00000422425+15739_1402181448.0Region4 X 308-326 AA approximate repeats
HgenePLB1chr2:28719036chr2:28999716ENST00000541605+1181403_14450424.0RegionNecessary for membrane localization
HgenePLB1chr2:28719036chr2:28999716ENST00000541605+11839_14020424.0Region4 X 308-326 AA approximate repeats
HgenePLB1chr2:28719036chr2:28999716ENST00000327757+1581064_1402181459.0Repeat4
HgenePLB1chr2:28719036chr2:28999716ENST00000327757+158362_707181459.0Repeat2
HgenePLB1chr2:28719036chr2:28999716ENST00000327757+15839_347181459.0Repeat1
HgenePLB1chr2:28719036chr2:28999716ENST00000327757+158708_1054181459.0Repeat3
HgenePLB1chr2:28719036chr2:28999716ENST00000329020+1211064_14020489.0Repeat4
HgenePLB1chr2:28719036chr2:28999716ENST00000329020+121362_7070489.0Repeat2
HgenePLB1chr2:28719036chr2:28999716ENST00000329020+12139_3470489.0Repeat1
HgenePLB1chr2:28719036chr2:28999716ENST00000329020+121708_10540489.0Repeat3
HgenePLB1chr2:28719036chr2:28999716ENST00000422425+1571064_1402181448.0Repeat4
HgenePLB1chr2:28719036chr2:28999716ENST00000422425+157362_707181448.0Repeat2
HgenePLB1chr2:28719036chr2:28999716ENST00000422425+15739_347181448.0Repeat1
HgenePLB1chr2:28719036chr2:28999716ENST00000422425+157708_1054181448.0Repeat3
HgenePLB1chr2:28719036chr2:28999716ENST00000541605+1181064_14020424.0Repeat4
HgenePLB1chr2:28719036chr2:28999716ENST00000541605+118362_7070424.0Repeat2
HgenePLB1chr2:28719036chr2:28999716ENST00000541605+11839_3470424.0Repeat1
HgenePLB1chr2:28719036chr2:28999716ENST00000541605+118708_10540424.0Repeat3
HgenePLB1chr2:28719036chr2:28999716ENST00000327757+1581439_1458181459.0Topological domainCytoplasmic
HgenePLB1chr2:28719036chr2:28999716ENST00000327757+15822_1417181459.0Topological domainExtracellular
HgenePLB1chr2:28719036chr2:28999716ENST00000329020+1211439_14580489.0Topological domainCytoplasmic
HgenePLB1chr2:28719036chr2:28999716ENST00000329020+12122_14170489.0Topological domainExtracellular
HgenePLB1chr2:28719036chr2:28999716ENST00000422425+1571439_1458181448.0Topological domainCytoplasmic
HgenePLB1chr2:28719036chr2:28999716ENST00000422425+15722_1417181448.0Topological domainExtracellular
HgenePLB1chr2:28719036chr2:28999716ENST00000541605+1181439_14580424.0Topological domainCytoplasmic
HgenePLB1chr2:28719036chr2:28999716ENST00000541605+11822_14170424.0Topological domainExtracellular
HgenePLB1chr2:28719036chr2:28999716ENST00000327757+1581418_1438181459.0TransmembraneHelical
HgenePLB1chr2:28719036chr2:28999716ENST00000329020+1211418_14380489.0TransmembraneHelical
HgenePLB1chr2:28719036chr2:28999716ENST00000422425+1571418_1438181448.0TransmembraneHelical
HgenePLB1chr2:28719036chr2:28999716ENST00000541605+1181418_14380424.0TransmembraneHelical


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Fusion Gene Sequence for PLB1-PPP1CB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>65940_65940_1_PLB1-PPP1CB_PLB1_chr2_28719036_ENST00000327757_PPP1CB_chr2_28999716_ENST00000296122_length(transcript)=3376nt_BP=99nt
GGAGCAGCTCTTCCAGAGGCCCGAGTCACCTGGAGCATTCTGGCATGGGGCTGCGGCCAGGCATTTTCCTCCTGGAGCTGCTGCTGCTTC
TGGGGCAAGTACGAGGATGTCGTCCAGGAAAGATTGTGCAGATGACTGAAGCAGAAGTTCGAGGCTTATGTATCAAGTCTCGGGAGATCT
TTCTCAGCCAGCCTATTCTTTTGGAATTGGAAGCACCGCTGAAAATTTGTGGAGATATTCATGGACAATATACAGATTTACTGAGATTAT
TTGAATATGGAGGTTTCCCACCAGAAGCCAACTATCTTTTCTTAGGAGATTATGTGGACAGAGGAAAGCAGTCTTTGGAAACCATTTGTT
TGCTATTGGCTTATAAAATCAAATATCCAGAGAACTTCTTTCTCTTAAGAGGAAACCATGAGTGTGCTAGCATCAATCGCATTTATGGAT
TCTATGATGAATGCAAACGAAGATTTAATATTAAATTGTGGAAGACCTTCACTGATTGTTTTAACTGTCTGCCTATAGCAGCCATTGTGG
ATGAGAAGATCTTCTGTTGTCATGGAGGATTGTCACCAGACCTGCAATCTATGGAGCAGATTCGGAGAATTATGAGACCTACTGATGTCC
CTGATACAGGTTTGCTCTGTGATTTGCTATGGTCTGATCCAGATAAGGATGTGCAAGGCTGGGGAGAAAATGATCGTGGTGTTTCCTTTA
CTTTTGGAGCTGATGTAGTCAGTAAATTTCTGAATCGTCATGATTTAGATTTGATTTGTCGAGCTCATCAGGTGGTGGAAGATGGATATG
AATTTTTTGCTAAACGACAGTTGGTAACCTTATTTTCAGCCCCAAATTACTGTGGCGAGTTTGATAATGCTGGTGGAATGATGAGTGTGG
ATGAAACTTTGATGTGTTCATTTCAGATATTGAAACCATCTGAAAAGAAAGCTAAATACCAGTATGGTGGACTGAATTCTGGACGTCCTG
TCACTCCACCTCGAACAGCTAATCCGCCGAAGAAAAGGTGAAGAAAGGAATTCTGTAAAGAAACCATCAGATTTGTTAAGGACATACTTC
ATAATATATAAGTGTGCACTGTAAAACCATCCAGCCATTTGACACCCTTTATGATGTCACACCTTTAACTTAAGGAGACGGGTAAAGGAT
CTTAAATTTTTTTCTAATAGAAAGATGTGCTACACTGTATTGTAATAAGTATACTCTGTTATAGTCAACAAAGTTAAATCCAAATTCAAA
ATTATCCATTAAAGTTACATCTTCATGTATCACAATTTTTAAAGTTGAAAAGCATCCCAGTTAAACTAGATGTGATAGTTAAACCAGATG
AAAGCATGATGATCCATCTGTGTAATGTGGTTTTAGTGTTGCTTGGTTGTTTAATTATTTTGAGCTTGTTTTGTTTTTGTTTGTTTTCAC
TAGAATAATGGCAAATACTTCTAATTTTTTTCCCTAAACATTTTTAAAAGTGAAATATGGGAAGAGCTTTACAGACATTCACCAACTATT
ATTTTCCCTTGTTTATCTACTTAGATATCTGTTTAATCTTACTAAGAAAACTTTCGCCTCATTACATTAAAAAGGAATTTTAGAGATTGA
TTGTTTTAAAAAAAAATACGCACATTGTCCAATCCAGTGATTTTAATCATACAGTTTGACTGGGCAAACTTTACAGCTGATAGTGAATAT
TTTGCTTTATACAGGAATTGACACTGATTTGGATTTGTGCACTCTAATTTTTAACTTATTGATGCTCTATTGTGCAGTAGCATTTCATTT
AAGATAAGGCTCATATAGTATTACCCAACTAGTTGGTAATGTGATTATGTGGTACCTTGGCTTTAGGTTTTCATTCGCACGGAACACCTT
TTGGCATGCTTAACTTCCTGGTAACACCTTCACCTGCATTGGTTTTCTTTTTCTTTTTTCTTTCTTTTTTTTTTTTTTTTTTTTTTTGAG
TTGTTGTTTGTTTTTAGATCCACAGTACATGAGAATCCTTTTTTGACAAGCCTTGGAAAGCTGACACTGTCTCTTTTTCCTCCCTCTATA
CGAAGGATGTATTTAAATGAATGCTGGTCAGTGGGACATTTTGTCAACTATGGGTATTGGGTGCTTAACTGTCTAATATTGCCATGTGAA
TGTTGTATACGATTGTAAGGCTTATGTCACTAAAGATTTTTATTCTGATTTTTTCATAATCAAAGGTCATATGATACTGTATAGACAAGC
TTTGTAGTGAAGTATAGTAGCAATAATTTCTGTACCTGATCAAGTTTATTGCAGCCTTTCTTTTCCTATTTCTTTTTTTTAAGGGTTAGT
ATTAACAAATGGCAATGAGTAGAAAAGTTAACATGAAGATTTTAGAAGGAGAGAACTTACAGGACACAGATTTGTGATTCTTTGACTGTG
ACACTATTGGATGTGATTCTAAAAGCTTTTATTGAGCATTGTCAAATTTGTAAGCTTCATAGGGATGGACATCATATCTATAATGCCCTT
CTATATGTGCTACCATAGATGTGACATTTTTGACCTTAATATCGTCTTTGAAAATGTTAAATTGAGAAACCTGTTAACTTACATTTTATG
AATTGGCACATTGTATTACTTACTGCAAGAGATATTTCATTTTCAGCACAGTGCAAAAGTTCTTTAAAATGCATATGTCTTTTTTTCTAA
TTCCGTTTTGTTTTAAAGCACATTTTAAATGTAGTTTTCTCATTTAGTAAAAGTTGTCTAATTGATATGAAGCCTGACTGATTTTTTTTT
TCCTTACAGTGAGACATTTAAGCACACATTTTATTCACATAGATACTATGTCCTTGACATATTGAAATGATTCTTTTCTGAAAGTATTCA
TGATCTGCATATGATGTATTAGGTTAGGTCACAAAGGTTTTATCTGAGGTGATTTAAATAACTTCCTGATTGGAGTGTGTAAGCTGAGCG
ATTTCTAATAAAATTTTAGTTGTACACTTTTAGTAGTCATAGTGAAGCAGGTCTAGAAAATAAGCCTTTGGCAGGGAAAAAGGGCAATGT
TGATTAATCTCAGTATTAAACCACATTAATCTGTATCCCATTGTCTGGCTTTTGTAAATTCATCCAGGTCAAGACTAAGTATGTTGGTTA
ATAGGAATCCTTTTTTTTTTTTTTAAAGACTAAATGTGAAAAAATAATCACTACTTAAGCTAATTAATATTGGTCATTAAATTTAAAGGA
TGGAAATTTATCATGTTTAAAAATTATTCAAGCACTCTTAAAACCACTTAAACAGCCTCCAGTCATAAAAATGTGTTCTTTACAAATATT

>65940_65940_1_PLB1-PPP1CB_PLB1_chr2_28719036_ENST00000327757_PPP1CB_chr2_28999716_ENST00000296122_length(amino acids)=333AA_BP=1
MEHSGMGLRPGIFLLELLLLLGQVRGCRPGKIVQMTEAEVRGLCIKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPEA
NYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRFNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGG
LSPDLQSMEQIRRIMRPTDVPDTGLLCDLLWSDPDKDVQGWGENDRGVSFTFGADVVSKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVT

--------------------------------------------------------------
>65940_65940_2_PLB1-PPP1CB_PLB1_chr2_28719036_ENST00000327757_PPP1CB_chr2_28999716_ENST00000358506_length(transcript)=4658nt_BP=99nt
GGAGCAGCTCTTCCAGAGGCCCGAGTCACCTGGAGCATTCTGGCATGGGGCTGCGGCCAGGCATTTTCCTCCTGGAGCTGCTGCTGCTTC
TGGGGCAAGTACGAGGATGTCGTCCAGGAAAGATTGTGCAGATGACTGAAGCAGAAGTTCGAGGCTTATGTATCAAGTCTCGGGAGATCT
TTCTCAGCCAGCCTATTCTTTTGGAATTGGAAGCACCGCTGAAAATTTGTGGAGATATTCATGGACAATATACAGATTTACTGAGATTAT
TTGAATATGGAGGTTTCCCACCAGAAGCCAACTATCTTTTCTTAGGAGATTATGTGGACAGAGGAAAGCAGTCTTTGGAAACCATTTGTT
TGCTATTGGCTTATAAAATCAAATATCCAGAGAACTTCTTTCTCTTAAGAGGAAACCATGAGTGTGCTAGCATCAATCGCATTTATGGAT
TCTATGATGAATGCAAACGAAGATTTAATATTAAATTGTGGAAGACCTTCACTGATTGTTTTAACTGTCTGCCTATAGCAGCCATTGTGG
ATGAGAAGATCTTCTGTTGTCATGGAGGATTGTCACCAGACCTGCAATCTATGGAGCAGATTCGGAGAATTATGAGACCTACTGATGTCC
CTGATACAGGTTTGCTCTGTGATTTGCTATGGTCTGATCCAGATAAGGATGTGCAAGGCTGGGGAGAAAATGATCGTGGTGTTTCCTTTA
CTTTTGGAGCTGATGTAGTCAGTAAATTTCTGAATCGTCATGATTTAGATTTGATTTGTCGAGCTCATCAGGTGGTGGAAGATGGATATG
AATTTTTTGCTAAACGACAGTTGGTAACCTTATTTTCAGCCCCAAATTACTGTGGCGAGTTTGATAATGCTGGTGGAATGATGAGTGTGG
ATGAAACTTTGATGTGTTCATTTCAGATATTGAAACCATCTGAAAAGAAAGCTAAATACCAGTATGGTGGACTGAATTCTGGACGTCCTG
TCACTCCACCTCGAACAGCTAATCCGCCGAAGAAAAGGTGAAGAAAGGAATTCTGTAAAGAAACCATCAGATTTGTTAAGGACATACTTC
ATAATATATAAGTGTGCACTGTAAAACCATCCAGCCATTTGACACCCTTTATGATGTCACACCTTTAACTTAAGGAGACGGGTAAAGGAT
CTTAAATTTTTTTCTAATAGAAAGATGTGCTACACTGTATTGTAATAAGTATACTCTGTTATAGTCAACAAAGTTAAATCCAAATTCAAA
ATTATCCATTAAAGTTACATCTTCATGTATCACAATTTTTAAAGTTGAAAAGCATCCCAGTTAAACTAGATGTGATAGTTAAACCAGATG
AAAGCATGATGATCCATCTGTGTAATGTGGTTTTAGTGTTGCTTGGTTGTTTAATTATTTTGAGCTTGTTTTGTTTTTGTTTGTTTTCAC
TAGAATAATGGCAAATACTTCTAATTTTTTTCCCTAAACATTTTTAAAAGTGAAATATGGGAAGAGCTTTACAGACATTCACCAACTATT
ATTTTCCCTTGTTTATCTACTTAGATATCTGTTTAATCTTACTAAGAAAACTTTCGCCTCATTACATTAAAAAGGAATTTTAGAGATTGA
TTGTTTTAAAAAAAAATACGCACATTGTCCAATCCAGTGATTTTAATCATACAGTTTGACTGGGCAAACTTTACAGCTGATAGTGAATAT
TTTGCTTTATACAGGAATTGACACTGATTTGGATTTGTGCACTCTAATTTTTAACTTATTGATGCTCTATTGTGCAGTAGCATTTCATTT
AAGATAAGGCTCATATAGTATTACCCAACTAGTTGGTAATGTGATTATGTGGTACCTTGGCTTTAGGTTTTCATTCGCACGGAACACCTT
TTGGCATGCTTAACTTCCTGGTAACACCTTCACCTGCATTGGTTTTCTTTTTCTTTTTTCTTTCTTTTTTTTTTTTTTTTTTTTTTTGAG
TTGTTGTTTGTTTTTAGATCCACAGTACATGAGAATCCTTTTTTGACAAGCCTTGGAAAGCTGACACTGTCTCTTTTTCCTCCCTCTATA
CGAAGGATGTATTTAAATGAATGCTGGTCAGTGGGACATTTTGTCAACTATGGGTATTGGGTGCTTAACTGTCTAATATTGCCATGTGAA
TGTTGTATACGATTGTAAGGCTTATGTCACTAAAGATTTTTATTCTGATTTTTTCATAATCAAAGGTCATATGATACTGTATAGACAAGC
TTTGTAGTGAAGTATAGTAGCAATAATTTCTGTACCTGATCAAGTTTATTGCAGCCTTTCTTTTCCTATTTCTTTTTTTTAAGGGTTAGT
ATTAACAAATGGCAATGAGTAGAAAAGTTAACATGAAGATTTTAGAAGGAGAGAACTTACAGGACACAGATTTGTGATTCTTTGACTGTG
ACACTATTGGATGTGATTCTAAAAGCTTTTATTGAGCATTGTCAAATTTGTAAGCTTCATAGGGATGGACATCATATCTATAATGCCCTT
CTATATGTGCTACCATAGATGTGACATTTTTGACCTTAATATCGTCTTTGAAAATGTTAAATTGAGAAACCTGTTAACTTACATTTTATG
AATTGGCACATTGTATTACTTACTGCAAGAGATATTTCATTTTCAGCACAGTGCAAAAGTTCTTTAAAATGCATATGTCTTTTTTTCTAA
TTCCGTTTTGTTTTAAAGCACATTTTAAATGTAGTTTTCTCATTTAGTAAAAGTTGTCTAATTGATATGAAGCCTGACTGATTTTTTTTT
TCCTTACAGTGAGACATTTAAGCACACATTTTATTCACATAGATACTATGTCCTTGACATATTGAAATGATTCTTTTCTGAAAGTATTCA
TGATCTGCATATGATGTATTAGGTTAGGTCACAAAGGTTTTATCTGAGGTGATTTAAATAACTTCCTGATTGGAGTGTGTAAGCTGAGCG
ATTTCTAATAAAATTTTAGTTGTACACTTTTAGTAGTCATAGTGAAGCAGGTCTAGAAAATAAGCCTTTGGCAGGGAAAAAGGGCAATGT
TGATTAATCTCAGTATTAAACCACATTAATCTGTATCCCATTGTCTGGCTTTTGTAAATTCATCCAGGTCAAGACTAAGTATGTTGGTTA
ATAGGAATCCTTTTTTTTTTTTTTAAAGACTAAATGTGAAAAAATAATCACTACTTAAGCTAATTAATATTGGTCATTAAATTTAAAGGA
TGGAAATTTATCATGTTTAAAAATTATTCAAGCACTCTTAAAACCACTTAAACAGCCTCCAGTCATAAAAATGTGTTCTTTACAAATATT
TGCTTGGCAACACGACTTGAAATAAATAAAACTTTGTTTCTTAGGAGAAAATGATTCTGTAATTCCAGTGTCACTAATTTATATTGTTCT
TTCCTCTGATTTTTTTCAGGTTAGTGATTTTTTTGTATACAATTTAATCCAAATGTTATGACATTCAGAAATCATGAAACACAGTAGATA
TCTGTTATAATGTGGTGTATCACATGGATTATAAAGCAAAGTTATGGTCGATTTCTATTCTTGAAAGAATCAACTACAGTGAATCCTTTG
CATTTGAAGCCTTAACATGCATTGCTTTAATTTTGCCCAGGGACAAATTTTAATAATCAGCAAGACTGGTTTGTGCAAAGCGTTGAGTCA
TCAGGTATTTAGAGCCTAGCCAGCTACCCAGTATCCATGCTGCCATATCCCTTCATTGTAAAAAGTACCTAAACATTCGTGAAATGATTT
TTTTTAGCTGAAAAATGCTGGCAAGAAGAATTTTAAAGCTTAAAATAGGTGGTAAATTTGAAGTATGAGTGTGTTCACGAGAAACATAGG
CTTTTCAAAAAAATTTTTATTCAAGGCAAAGCAAGGAACATCTTGAGATATGTCTCAAGAATATAAAGATGTATTATTTTAAGCCAAGGA
GCTGAAATATATCTCAGTTTATAAATTCAGGTATATTCTTTTTGTCTCCATGGCAACCATAACTTTTGAACCAAAAAAAATTGTTTTTAC
ATCTTTATGCTGAAAATGTGTTTAGATTAGGAATATGGTCGGGCTGAATTTGCTGTTGCTCCCTAACCAAATCCACCTCTTGTTTTCCTT
GTGAGTCCATGGCTAAATCAAAGCTGCCCCTGAGAAGAGACTTAATCCAAGCCTGATTGTACTAGTGGCATCACTTAGAAGTAGGCTTTC
CCTCTTCCTAGTAGATCTCAATGTTTTATAATTCCTTAAAACAGCTGAAAATTGGGACAACATACTTTACGCAATGAACAGTAGTTAAAT
AGGAAATAAACTAGTTCCATATAAGTATACACCTAGAGTTTTAATTACCTTTATAATGTTTCTTAAAAGTGAAACTTAGATACAATTGTG
ATTGGATACTTAGATACTAAGTGAAACTTAGTGTAACAATTTTGATCTGTTAAATTGGATTTTACATGTACATTTGAATGCCAGAATTTC
TAAATAAATCCCCTGGTTAGGAAATTTTAAAAGTCAAAGCTTGTTTTCTTCAACCACTACCTTCTACATTGGTTGACTTAGACCGTAAGC

>65940_65940_2_PLB1-PPP1CB_PLB1_chr2_28719036_ENST00000327757_PPP1CB_chr2_28999716_ENST00000358506_length(amino acids)=333AA_BP=1
MEHSGMGLRPGIFLLELLLLLGQVRGCRPGKIVQMTEAEVRGLCIKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPEA
NYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRFNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGG
LSPDLQSMEQIRRIMRPTDVPDTGLLCDLLWSDPDKDVQGWGENDRGVSFTFGADVVSKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVT

--------------------------------------------------------------
>65940_65940_3_PLB1-PPP1CB_PLB1_chr2_28719036_ENST00000327757_PPP1CB_chr2_28999716_ENST00000395366_length(transcript)=4668nt_BP=99nt
GGAGCAGCTCTTCCAGAGGCCCGAGTCACCTGGAGCATTCTGGCATGGGGCTGCGGCCAGGCATTTTCCTCCTGGAGCTGCTGCTGCTTC
TGGGGCAAGTACGAGGATGTCGTCCAGGAAAGATTGTGCAGATGACTGAAGCAGAAGTTCGAGGCTTATGTATCAAGTCTCGGGAGATCT
TTCTCAGCCAGCCTATTCTTTTGGAATTGGAAGCACCGCTGAAAATTTGTGGAGATATTCATGGACAATATACAGATTTACTGAGATTAT
TTGAATATGGAGGTTTCCCACCAGAAGCCAACTATCTTTTCTTAGGAGATTATGTGGACAGAGGAAAGCAGTCTTTGGAAACCATTTGTT
TGCTATTGGCTTATAAAATCAAATATCCAGAGAACTTCTTTCTCTTAAGAGGAAACCATGAGTGTGCTAGCATCAATCGCATTTATGGAT
TCTATGATGAATGCAAACGAAGATTTAATATTAAATTGTGGAAGACCTTCACTGATTGTTTTAACTGTCTGCCTATAGCAGCCATTGTGG
ATGAGAAGATCTTCTGTTGTCATGGAGGATTGTCACCAGACCTGCAATCTATGGAGCAGATTCGGAGAATTATGAGACCTACTGATGTCC
CTGATACAGGTTTGCTCTGTGATTTGCTATGGTCTGATCCAGATAAGGATGTGCAAGGCTGGGGAGAAAATGATCGTGGTGTTTCCTTTA
CTTTTGGAGCTGATGTAGTCAGTAAATTTCTGAATCGTCATGATTTAGATTTGATTTGTCGAGCTCATCAGGTGGTGGAAGATGGATATG
AATTTTTTGCTAAACGACAGTTGGTAACCTTATTTTCAGCCCCAAATTACTGTGGCGAGTTTGATAATGCTGGTGGAATGATGAGTGTGG
ATGAAACTTTGATGTGTTCATTTCAGATATTGAAACCATCTGAAAAGAAAGCTAAATACCAGTATGGTGGACTGAATTCTGGACGTCCTG
TCACTCCACCTCGAACAGCTAATCCGCCGAAGAAAAGGTGAAGAAAGGAATTCTGTAAAGAAACCATCAGATTTGTTAAGGACATACTTC
ATAATATATAAGTGTGCACTGTAAAACCATCCAGCCATTTGACACCCTTTATGATGTCACACCTTTAACTTAAGGAGACGGGTAAAGGAT
CTTAAATTTTTTTCTAATAGAAAGATGTGCTACACTGTATTGTAATAAGTATACTCTGTTATAGTCAACAAAGTTAAATCCAAATTCAAA
ATTATCCATTAAAGTTACATCTTCATGTATCACAATTTTTAAAGTTGAAAAGCATCCCAGTTAAACTAGATGTGATAGTTAAACCAGATG
AAAGCATGATGATCCATCTGTGTAATGTGGTTTTAGTGTTGCTTGGTTGTTTAATTATTTTGAGCTTGTTTTGTTTTTGTTTGTTTTCAC
TAGAATAATGGCAAATACTTCTAATTTTTTTCCCTAAACATTTTTAAAAGTGAAATATGGGAAGAGCTTTACAGACATTCACCAACTATT
ATTTTCCCTTGTTTATCTACTTAGATATCTGTTTAATCTTACTAAGAAAACTTTCGCCTCATTACATTAAAAAGGAATTTTAGAGATTGA
TTGTTTTAAAAAAAAATACGCACATTGTCCAATCCAGTGATTTTAATCATACAGTTTGACTGGGCAAACTTTACAGCTGATAGTGAATAT
TTTGCTTTATACAGGAATTGACACTGATTTGGATTTGTGCACTCTAATTTTTAACTTATTGATGCTCTATTGTGCAGTAGCATTTCATTT
AAGATAAGGCTCATATAGTATTACCCAACTAGTTGGTAATGTGATTATGTGGTACCTTGGCTTTAGGTTTTCATTCGCACGGAACACCTT
TTGGCATGCTTAACTTCCTGGTAACACCTTCACCTGCATTGGTTTTCTTTTTCTTTTTTCTTTCTTTTTTTTTTTTTTTTTTTTTTTGAG
TTGTTGTTTGTTTTTAGATCCACAGTACATGAGAATCCTTTTTTGACAAGCCTTGGAAAGCTGACACTGTCTCTTTTTCCTCCCTCTATA
CGAAGGATGTATTTAAATGAATGCTGGTCAGTGGGACATTTTGTCAACTATGGGTATTGGGTGCTTAACTGTCTAATATTGCCATGTGAA
TGTTGTATACGATTGTAAGGCTTATGTCACTAAAGATTTTTATTCTGATTTTTTCATAATCAAAGGTCATATGATACTGTATAGACAAGC
TTTGTAGTGAAGTATAGTAGCAATAATTTCTGTACCTGATCAAGTTTATTGCAGCCTTTCTTTTCCTATTTCTTTTTTTTAAGGGTTAGT
ATTAACAAATGGCAATGAGTAGAAAAGTTAACATGAAGATTTTAGAAGGAGAGAACTTACAGGACACAGATTTGTGATTCTTTGACTGTG
ACACTATTGGATGTGATTCTAAAAGCTTTTATTGAGCATTGTCAAATTTGTAAGCTTCATAGGGATGGACATCATATCTATAATGCCCTT
CTATATGTGCTACCATAGATGTGACATTTTTGACCTTAATATCGTCTTTGAAAATGTTAAATTGAGAAACCTGTTAACTTACATTTTATG
AATTGGCACATTGTATTACTTACTGCAAGAGATATTTCATTTTCAGCACAGTGCAAAAGTTCTTTAAAATGCATATGTCTTTTTTTCTAA
TTCCGTTTTGTTTTAAAGCACATTTTAAATGTAGTTTTCTCATTTAGTAAAAGTTGTCTAATTGATATGAAGCCTGACTGATTTTTTTTT
TCCTTACAGTGAGACATTTAAGCACACATTTTATTCACATAGATACTATGTCCTTGACATATTGAAATGATTCTTTTCTGAAAGTATTCA
TGATCTGCATATGATGTATTAGGTTAGGTCACAAAGGTTTTATCTGAGGTGATTTAAATAACTTCCTGATTGGAGTGTGTAAGCTGAGCG
ATTTCTAATAAAATTTTAGTTGTACACTTTTAGTAGTCATAGTGAAGCAGGTCTAGAAAATAAGCCTTTGGCAGGGAAAAAGGGCAATGT
TGATTAATCTCAGTATTAAACCACATTAATCTGTATCCCATTGTCTGGCTTTTGTAAATTCATCCAGGTCAAGACTAAGTATGTTGGTTA
ATAGGAATCCTTTTTTTTTTTTTTAAAGACTAAATGTGAAAAAATAATCACTACTTAAGCTAATTAATATTGGTCATTAAATTTAAAGGA
TGGAAATTTATCATGTTTAAAAATTATTCAAGCACTCTTAAAACCACTTAAACAGCCTCCAGTCATAAAAATGTGTTCTTTACAAATATT
TGCTTGGCAACACGACTTGAAATAAATAAAACTTTGTTTCTTAGGAGAAAATGATTCTGTAATTCCAGTGTCACTAATTTATATTGTTCT
TTCCTCTGATTTTTTTCAGGTTAGTGATTTTTTTGTATACAATTTAATCCAAATGTTATGACATTCAGAAATCATGAAACACAGTAGATA
TCTGTTATAATGTGGTGTATCACATGGATTATAAAGCAAAGTTATGGTCGATTTCTATTCTTGAAAGAATCAACTACAGTGAATCCTTTG
CATTTGAAGCCTTAACATGCATTGCTTTAATTTTGCCCAGGGACAAATTTTAATAATCAGCAAGACTGGTTTGTGCAAAGCGTTGAGTCA
TCAGGTATTTAGAGCCTAGCCAGCTACCCAGTATCCATGCTGCCATATCCCTTCATTGTAAAAAGTACCTAAACATTCGTGAAATGATTT
TTTTTAGCTGAAAAATGCTGGCAAGAAGAATTTTAAAGCTTAAAATAGGTGGTAAATTTGAAGTATGAGTGTGTTCACGAGAAACATAGG
CTTTTCAAAAAAATTTTTATTCAAGGCAAAGCAAGGAACATCTTGAGATATGTCTCAAGAATATAAAGATGTATTATTTTAAGCCAAGGA
GCTGAAATATATCTCAGTTTATAAATTCAGGTATATTCTTTTTGTCTCCATGGCAACCATAACTTTTGAACCAAAAAAAATTGTTTTTAC
ATCTTTATGCTGAAAATGTGTTTAGATTAGGAATATGGTCGGGCTGAATTTGCTGTTGCTCCCTAACCAAATCCACCTCTTGTTTTCCTT
GTGAGTCCATGGCTAAATCAAAGCTGCCCCTGAGAAGAGACTTAATCCAAGCCTGATTGTACTAGTGGCATCACTTAGAAGTAGGCTTTC
CCTCTTCCTAGTAGATCTCAATGTTTTATAATTCCTTAAAACAGCTGAAAATTGGGACAACATACTTTACGCAATGAACAGTAGTTAAAT
AGGAAATAAACTAGTTCCATATAAGTATACACCTAGAGTTTTAATTACCTTTATAATGTTTCTTAAAAGTGAAACTTAGATACAATTGTG
ATTGGATACTTAGATACTAAGTGAAACTTAGTGTAACAATTTTGATCTGTTAAATTGGATTTTACATGTACATTTGAATGCCAGAATTTC
TAAATAAATCCCCTGGTTAGGAAATTTTAAAAGTCAAAGCTTGTTTTCTTCAACCACTACCTTCTACATTGGTTGACTTAGACCGTAAGC

>65940_65940_3_PLB1-PPP1CB_PLB1_chr2_28719036_ENST00000327757_PPP1CB_chr2_28999716_ENST00000395366_length(amino acids)=333AA_BP=1
MEHSGMGLRPGIFLLELLLLLGQVRGCRPGKIVQMTEAEVRGLCIKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPEA
NYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRFNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGG
LSPDLQSMEQIRRIMRPTDVPDTGLLCDLLWSDPDKDVQGWGENDRGVSFTFGADVVSKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVT

--------------------------------------------------------------
>65940_65940_4_PLB1-PPP1CB_PLB1_chr2_28719036_ENST00000422425_PPP1CB_chr2_28999716_ENST00000296122_length(transcript)=3376nt_BP=99nt
GGAGCAGCTCTTCCAGAGGCCCGAGTCACCTGGAGCATTCTGGCATGGGGCTGCGGCCAGGCATTTTCCTCCTGGAGCTGCTGCTGCTTC
TGGGGCAAGTACGAGGATGTCGTCCAGGAAAGATTGTGCAGATGACTGAAGCAGAAGTTCGAGGCTTATGTATCAAGTCTCGGGAGATCT
TTCTCAGCCAGCCTATTCTTTTGGAATTGGAAGCACCGCTGAAAATTTGTGGAGATATTCATGGACAATATACAGATTTACTGAGATTAT
TTGAATATGGAGGTTTCCCACCAGAAGCCAACTATCTTTTCTTAGGAGATTATGTGGACAGAGGAAAGCAGTCTTTGGAAACCATTTGTT
TGCTATTGGCTTATAAAATCAAATATCCAGAGAACTTCTTTCTCTTAAGAGGAAACCATGAGTGTGCTAGCATCAATCGCATTTATGGAT
TCTATGATGAATGCAAACGAAGATTTAATATTAAATTGTGGAAGACCTTCACTGATTGTTTTAACTGTCTGCCTATAGCAGCCATTGTGG
ATGAGAAGATCTTCTGTTGTCATGGAGGATTGTCACCAGACCTGCAATCTATGGAGCAGATTCGGAGAATTATGAGACCTACTGATGTCC
CTGATACAGGTTTGCTCTGTGATTTGCTATGGTCTGATCCAGATAAGGATGTGCAAGGCTGGGGAGAAAATGATCGTGGTGTTTCCTTTA
CTTTTGGAGCTGATGTAGTCAGTAAATTTCTGAATCGTCATGATTTAGATTTGATTTGTCGAGCTCATCAGGTGGTGGAAGATGGATATG
AATTTTTTGCTAAACGACAGTTGGTAACCTTATTTTCAGCCCCAAATTACTGTGGCGAGTTTGATAATGCTGGTGGAATGATGAGTGTGG
ATGAAACTTTGATGTGTTCATTTCAGATATTGAAACCATCTGAAAAGAAAGCTAAATACCAGTATGGTGGACTGAATTCTGGACGTCCTG
TCACTCCACCTCGAACAGCTAATCCGCCGAAGAAAAGGTGAAGAAAGGAATTCTGTAAAGAAACCATCAGATTTGTTAAGGACATACTTC
ATAATATATAAGTGTGCACTGTAAAACCATCCAGCCATTTGACACCCTTTATGATGTCACACCTTTAACTTAAGGAGACGGGTAAAGGAT
CTTAAATTTTTTTCTAATAGAAAGATGTGCTACACTGTATTGTAATAAGTATACTCTGTTATAGTCAACAAAGTTAAATCCAAATTCAAA
ATTATCCATTAAAGTTACATCTTCATGTATCACAATTTTTAAAGTTGAAAAGCATCCCAGTTAAACTAGATGTGATAGTTAAACCAGATG
AAAGCATGATGATCCATCTGTGTAATGTGGTTTTAGTGTTGCTTGGTTGTTTAATTATTTTGAGCTTGTTTTGTTTTTGTTTGTTTTCAC
TAGAATAATGGCAAATACTTCTAATTTTTTTCCCTAAACATTTTTAAAAGTGAAATATGGGAAGAGCTTTACAGACATTCACCAACTATT
ATTTTCCCTTGTTTATCTACTTAGATATCTGTTTAATCTTACTAAGAAAACTTTCGCCTCATTACATTAAAAAGGAATTTTAGAGATTGA
TTGTTTTAAAAAAAAATACGCACATTGTCCAATCCAGTGATTTTAATCATACAGTTTGACTGGGCAAACTTTACAGCTGATAGTGAATAT
TTTGCTTTATACAGGAATTGACACTGATTTGGATTTGTGCACTCTAATTTTTAACTTATTGATGCTCTATTGTGCAGTAGCATTTCATTT
AAGATAAGGCTCATATAGTATTACCCAACTAGTTGGTAATGTGATTATGTGGTACCTTGGCTTTAGGTTTTCATTCGCACGGAACACCTT
TTGGCATGCTTAACTTCCTGGTAACACCTTCACCTGCATTGGTTTTCTTTTTCTTTTTTCTTTCTTTTTTTTTTTTTTTTTTTTTTTGAG
TTGTTGTTTGTTTTTAGATCCACAGTACATGAGAATCCTTTTTTGACAAGCCTTGGAAAGCTGACACTGTCTCTTTTTCCTCCCTCTATA
CGAAGGATGTATTTAAATGAATGCTGGTCAGTGGGACATTTTGTCAACTATGGGTATTGGGTGCTTAACTGTCTAATATTGCCATGTGAA
TGTTGTATACGATTGTAAGGCTTATGTCACTAAAGATTTTTATTCTGATTTTTTCATAATCAAAGGTCATATGATACTGTATAGACAAGC
TTTGTAGTGAAGTATAGTAGCAATAATTTCTGTACCTGATCAAGTTTATTGCAGCCTTTCTTTTCCTATTTCTTTTTTTTAAGGGTTAGT
ATTAACAAATGGCAATGAGTAGAAAAGTTAACATGAAGATTTTAGAAGGAGAGAACTTACAGGACACAGATTTGTGATTCTTTGACTGTG
ACACTATTGGATGTGATTCTAAAAGCTTTTATTGAGCATTGTCAAATTTGTAAGCTTCATAGGGATGGACATCATATCTATAATGCCCTT
CTATATGTGCTACCATAGATGTGACATTTTTGACCTTAATATCGTCTTTGAAAATGTTAAATTGAGAAACCTGTTAACTTACATTTTATG
AATTGGCACATTGTATTACTTACTGCAAGAGATATTTCATTTTCAGCACAGTGCAAAAGTTCTTTAAAATGCATATGTCTTTTTTTCTAA
TTCCGTTTTGTTTTAAAGCACATTTTAAATGTAGTTTTCTCATTTAGTAAAAGTTGTCTAATTGATATGAAGCCTGACTGATTTTTTTTT
TCCTTACAGTGAGACATTTAAGCACACATTTTATTCACATAGATACTATGTCCTTGACATATTGAAATGATTCTTTTCTGAAAGTATTCA
TGATCTGCATATGATGTATTAGGTTAGGTCACAAAGGTTTTATCTGAGGTGATTTAAATAACTTCCTGATTGGAGTGTGTAAGCTGAGCG
ATTTCTAATAAAATTTTAGTTGTACACTTTTAGTAGTCATAGTGAAGCAGGTCTAGAAAATAAGCCTTTGGCAGGGAAAAAGGGCAATGT
TGATTAATCTCAGTATTAAACCACATTAATCTGTATCCCATTGTCTGGCTTTTGTAAATTCATCCAGGTCAAGACTAAGTATGTTGGTTA
ATAGGAATCCTTTTTTTTTTTTTTAAAGACTAAATGTGAAAAAATAATCACTACTTAAGCTAATTAATATTGGTCATTAAATTTAAAGGA
TGGAAATTTATCATGTTTAAAAATTATTCAAGCACTCTTAAAACCACTTAAACAGCCTCCAGTCATAAAAATGTGTTCTTTACAAATATT

>65940_65940_4_PLB1-PPP1CB_PLB1_chr2_28719036_ENST00000422425_PPP1CB_chr2_28999716_ENST00000296122_length(amino acids)=333AA_BP=1
MEHSGMGLRPGIFLLELLLLLGQVRGCRPGKIVQMTEAEVRGLCIKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPEA
NYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRFNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGG
LSPDLQSMEQIRRIMRPTDVPDTGLLCDLLWSDPDKDVQGWGENDRGVSFTFGADVVSKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVT

--------------------------------------------------------------
>65940_65940_5_PLB1-PPP1CB_PLB1_chr2_28719036_ENST00000422425_PPP1CB_chr2_28999716_ENST00000358506_length(transcript)=4658nt_BP=99nt
GGAGCAGCTCTTCCAGAGGCCCGAGTCACCTGGAGCATTCTGGCATGGGGCTGCGGCCAGGCATTTTCCTCCTGGAGCTGCTGCTGCTTC
TGGGGCAAGTACGAGGATGTCGTCCAGGAAAGATTGTGCAGATGACTGAAGCAGAAGTTCGAGGCTTATGTATCAAGTCTCGGGAGATCT
TTCTCAGCCAGCCTATTCTTTTGGAATTGGAAGCACCGCTGAAAATTTGTGGAGATATTCATGGACAATATACAGATTTACTGAGATTAT
TTGAATATGGAGGTTTCCCACCAGAAGCCAACTATCTTTTCTTAGGAGATTATGTGGACAGAGGAAAGCAGTCTTTGGAAACCATTTGTT
TGCTATTGGCTTATAAAATCAAATATCCAGAGAACTTCTTTCTCTTAAGAGGAAACCATGAGTGTGCTAGCATCAATCGCATTTATGGAT
TCTATGATGAATGCAAACGAAGATTTAATATTAAATTGTGGAAGACCTTCACTGATTGTTTTAACTGTCTGCCTATAGCAGCCATTGTGG
ATGAGAAGATCTTCTGTTGTCATGGAGGATTGTCACCAGACCTGCAATCTATGGAGCAGATTCGGAGAATTATGAGACCTACTGATGTCC
CTGATACAGGTTTGCTCTGTGATTTGCTATGGTCTGATCCAGATAAGGATGTGCAAGGCTGGGGAGAAAATGATCGTGGTGTTTCCTTTA
CTTTTGGAGCTGATGTAGTCAGTAAATTTCTGAATCGTCATGATTTAGATTTGATTTGTCGAGCTCATCAGGTGGTGGAAGATGGATATG
AATTTTTTGCTAAACGACAGTTGGTAACCTTATTTTCAGCCCCAAATTACTGTGGCGAGTTTGATAATGCTGGTGGAATGATGAGTGTGG
ATGAAACTTTGATGTGTTCATTTCAGATATTGAAACCATCTGAAAAGAAAGCTAAATACCAGTATGGTGGACTGAATTCTGGACGTCCTG
TCACTCCACCTCGAACAGCTAATCCGCCGAAGAAAAGGTGAAGAAAGGAATTCTGTAAAGAAACCATCAGATTTGTTAAGGACATACTTC
ATAATATATAAGTGTGCACTGTAAAACCATCCAGCCATTTGACACCCTTTATGATGTCACACCTTTAACTTAAGGAGACGGGTAAAGGAT
CTTAAATTTTTTTCTAATAGAAAGATGTGCTACACTGTATTGTAATAAGTATACTCTGTTATAGTCAACAAAGTTAAATCCAAATTCAAA
ATTATCCATTAAAGTTACATCTTCATGTATCACAATTTTTAAAGTTGAAAAGCATCCCAGTTAAACTAGATGTGATAGTTAAACCAGATG
AAAGCATGATGATCCATCTGTGTAATGTGGTTTTAGTGTTGCTTGGTTGTTTAATTATTTTGAGCTTGTTTTGTTTTTGTTTGTTTTCAC
TAGAATAATGGCAAATACTTCTAATTTTTTTCCCTAAACATTTTTAAAAGTGAAATATGGGAAGAGCTTTACAGACATTCACCAACTATT
ATTTTCCCTTGTTTATCTACTTAGATATCTGTTTAATCTTACTAAGAAAACTTTCGCCTCATTACATTAAAAAGGAATTTTAGAGATTGA
TTGTTTTAAAAAAAAATACGCACATTGTCCAATCCAGTGATTTTAATCATACAGTTTGACTGGGCAAACTTTACAGCTGATAGTGAATAT
TTTGCTTTATACAGGAATTGACACTGATTTGGATTTGTGCACTCTAATTTTTAACTTATTGATGCTCTATTGTGCAGTAGCATTTCATTT
AAGATAAGGCTCATATAGTATTACCCAACTAGTTGGTAATGTGATTATGTGGTACCTTGGCTTTAGGTTTTCATTCGCACGGAACACCTT
TTGGCATGCTTAACTTCCTGGTAACACCTTCACCTGCATTGGTTTTCTTTTTCTTTTTTCTTTCTTTTTTTTTTTTTTTTTTTTTTTGAG
TTGTTGTTTGTTTTTAGATCCACAGTACATGAGAATCCTTTTTTGACAAGCCTTGGAAAGCTGACACTGTCTCTTTTTCCTCCCTCTATA
CGAAGGATGTATTTAAATGAATGCTGGTCAGTGGGACATTTTGTCAACTATGGGTATTGGGTGCTTAACTGTCTAATATTGCCATGTGAA
TGTTGTATACGATTGTAAGGCTTATGTCACTAAAGATTTTTATTCTGATTTTTTCATAATCAAAGGTCATATGATACTGTATAGACAAGC
TTTGTAGTGAAGTATAGTAGCAATAATTTCTGTACCTGATCAAGTTTATTGCAGCCTTTCTTTTCCTATTTCTTTTTTTTAAGGGTTAGT
ATTAACAAATGGCAATGAGTAGAAAAGTTAACATGAAGATTTTAGAAGGAGAGAACTTACAGGACACAGATTTGTGATTCTTTGACTGTG
ACACTATTGGATGTGATTCTAAAAGCTTTTATTGAGCATTGTCAAATTTGTAAGCTTCATAGGGATGGACATCATATCTATAATGCCCTT
CTATATGTGCTACCATAGATGTGACATTTTTGACCTTAATATCGTCTTTGAAAATGTTAAATTGAGAAACCTGTTAACTTACATTTTATG
AATTGGCACATTGTATTACTTACTGCAAGAGATATTTCATTTTCAGCACAGTGCAAAAGTTCTTTAAAATGCATATGTCTTTTTTTCTAA
TTCCGTTTTGTTTTAAAGCACATTTTAAATGTAGTTTTCTCATTTAGTAAAAGTTGTCTAATTGATATGAAGCCTGACTGATTTTTTTTT
TCCTTACAGTGAGACATTTAAGCACACATTTTATTCACATAGATACTATGTCCTTGACATATTGAAATGATTCTTTTCTGAAAGTATTCA
TGATCTGCATATGATGTATTAGGTTAGGTCACAAAGGTTTTATCTGAGGTGATTTAAATAACTTCCTGATTGGAGTGTGTAAGCTGAGCG
ATTTCTAATAAAATTTTAGTTGTACACTTTTAGTAGTCATAGTGAAGCAGGTCTAGAAAATAAGCCTTTGGCAGGGAAAAAGGGCAATGT
TGATTAATCTCAGTATTAAACCACATTAATCTGTATCCCATTGTCTGGCTTTTGTAAATTCATCCAGGTCAAGACTAAGTATGTTGGTTA
ATAGGAATCCTTTTTTTTTTTTTTAAAGACTAAATGTGAAAAAATAATCACTACTTAAGCTAATTAATATTGGTCATTAAATTTAAAGGA
TGGAAATTTATCATGTTTAAAAATTATTCAAGCACTCTTAAAACCACTTAAACAGCCTCCAGTCATAAAAATGTGTTCTTTACAAATATT
TGCTTGGCAACACGACTTGAAATAAATAAAACTTTGTTTCTTAGGAGAAAATGATTCTGTAATTCCAGTGTCACTAATTTATATTGTTCT
TTCCTCTGATTTTTTTCAGGTTAGTGATTTTTTTGTATACAATTTAATCCAAATGTTATGACATTCAGAAATCATGAAACACAGTAGATA
TCTGTTATAATGTGGTGTATCACATGGATTATAAAGCAAAGTTATGGTCGATTTCTATTCTTGAAAGAATCAACTACAGTGAATCCTTTG
CATTTGAAGCCTTAACATGCATTGCTTTAATTTTGCCCAGGGACAAATTTTAATAATCAGCAAGACTGGTTTGTGCAAAGCGTTGAGTCA
TCAGGTATTTAGAGCCTAGCCAGCTACCCAGTATCCATGCTGCCATATCCCTTCATTGTAAAAAGTACCTAAACATTCGTGAAATGATTT
TTTTTAGCTGAAAAATGCTGGCAAGAAGAATTTTAAAGCTTAAAATAGGTGGTAAATTTGAAGTATGAGTGTGTTCACGAGAAACATAGG
CTTTTCAAAAAAATTTTTATTCAAGGCAAAGCAAGGAACATCTTGAGATATGTCTCAAGAATATAAAGATGTATTATTTTAAGCCAAGGA
GCTGAAATATATCTCAGTTTATAAATTCAGGTATATTCTTTTTGTCTCCATGGCAACCATAACTTTTGAACCAAAAAAAATTGTTTTTAC
ATCTTTATGCTGAAAATGTGTTTAGATTAGGAATATGGTCGGGCTGAATTTGCTGTTGCTCCCTAACCAAATCCACCTCTTGTTTTCCTT
GTGAGTCCATGGCTAAATCAAAGCTGCCCCTGAGAAGAGACTTAATCCAAGCCTGATTGTACTAGTGGCATCACTTAGAAGTAGGCTTTC
CCTCTTCCTAGTAGATCTCAATGTTTTATAATTCCTTAAAACAGCTGAAAATTGGGACAACATACTTTACGCAATGAACAGTAGTTAAAT
AGGAAATAAACTAGTTCCATATAAGTATACACCTAGAGTTTTAATTACCTTTATAATGTTTCTTAAAAGTGAAACTTAGATACAATTGTG
ATTGGATACTTAGATACTAAGTGAAACTTAGTGTAACAATTTTGATCTGTTAAATTGGATTTTACATGTACATTTGAATGCCAGAATTTC
TAAATAAATCCCCTGGTTAGGAAATTTTAAAAGTCAAAGCTTGTTTTCTTCAACCACTACCTTCTACATTGGTTGACTTAGACCGTAAGC

>65940_65940_5_PLB1-PPP1CB_PLB1_chr2_28719036_ENST00000422425_PPP1CB_chr2_28999716_ENST00000358506_length(amino acids)=333AA_BP=1
MEHSGMGLRPGIFLLELLLLLGQVRGCRPGKIVQMTEAEVRGLCIKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPEA
NYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRFNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGG
LSPDLQSMEQIRRIMRPTDVPDTGLLCDLLWSDPDKDVQGWGENDRGVSFTFGADVVSKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVT

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>65940_65940_6_PLB1-PPP1CB_PLB1_chr2_28719036_ENST00000422425_PPP1CB_chr2_28999716_ENST00000395366_length(transcript)=4668nt_BP=99nt
GGAGCAGCTCTTCCAGAGGCCCGAGTCACCTGGAGCATTCTGGCATGGGGCTGCGGCCAGGCATTTTCCTCCTGGAGCTGCTGCTGCTTC
TGGGGCAAGTACGAGGATGTCGTCCAGGAAAGATTGTGCAGATGACTGAAGCAGAAGTTCGAGGCTTATGTATCAAGTCTCGGGAGATCT
TTCTCAGCCAGCCTATTCTTTTGGAATTGGAAGCACCGCTGAAAATTTGTGGAGATATTCATGGACAATATACAGATTTACTGAGATTAT
TTGAATATGGAGGTTTCCCACCAGAAGCCAACTATCTTTTCTTAGGAGATTATGTGGACAGAGGAAAGCAGTCTTTGGAAACCATTTGTT
TGCTATTGGCTTATAAAATCAAATATCCAGAGAACTTCTTTCTCTTAAGAGGAAACCATGAGTGTGCTAGCATCAATCGCATTTATGGAT
TCTATGATGAATGCAAACGAAGATTTAATATTAAATTGTGGAAGACCTTCACTGATTGTTTTAACTGTCTGCCTATAGCAGCCATTGTGG
ATGAGAAGATCTTCTGTTGTCATGGAGGATTGTCACCAGACCTGCAATCTATGGAGCAGATTCGGAGAATTATGAGACCTACTGATGTCC
CTGATACAGGTTTGCTCTGTGATTTGCTATGGTCTGATCCAGATAAGGATGTGCAAGGCTGGGGAGAAAATGATCGTGGTGTTTCCTTTA
CTTTTGGAGCTGATGTAGTCAGTAAATTTCTGAATCGTCATGATTTAGATTTGATTTGTCGAGCTCATCAGGTGGTGGAAGATGGATATG
AATTTTTTGCTAAACGACAGTTGGTAACCTTATTTTCAGCCCCAAATTACTGTGGCGAGTTTGATAATGCTGGTGGAATGATGAGTGTGG
ATGAAACTTTGATGTGTTCATTTCAGATATTGAAACCATCTGAAAAGAAAGCTAAATACCAGTATGGTGGACTGAATTCTGGACGTCCTG
TCACTCCACCTCGAACAGCTAATCCGCCGAAGAAAAGGTGAAGAAAGGAATTCTGTAAAGAAACCATCAGATTTGTTAAGGACATACTTC
ATAATATATAAGTGTGCACTGTAAAACCATCCAGCCATTTGACACCCTTTATGATGTCACACCTTTAACTTAAGGAGACGGGTAAAGGAT
CTTAAATTTTTTTCTAATAGAAAGATGTGCTACACTGTATTGTAATAAGTATACTCTGTTATAGTCAACAAAGTTAAATCCAAATTCAAA
ATTATCCATTAAAGTTACATCTTCATGTATCACAATTTTTAAAGTTGAAAAGCATCCCAGTTAAACTAGATGTGATAGTTAAACCAGATG
AAAGCATGATGATCCATCTGTGTAATGTGGTTTTAGTGTTGCTTGGTTGTTTAATTATTTTGAGCTTGTTTTGTTTTTGTTTGTTTTCAC
TAGAATAATGGCAAATACTTCTAATTTTTTTCCCTAAACATTTTTAAAAGTGAAATATGGGAAGAGCTTTACAGACATTCACCAACTATT
ATTTTCCCTTGTTTATCTACTTAGATATCTGTTTAATCTTACTAAGAAAACTTTCGCCTCATTACATTAAAAAGGAATTTTAGAGATTGA
TTGTTTTAAAAAAAAATACGCACATTGTCCAATCCAGTGATTTTAATCATACAGTTTGACTGGGCAAACTTTACAGCTGATAGTGAATAT
TTTGCTTTATACAGGAATTGACACTGATTTGGATTTGTGCACTCTAATTTTTAACTTATTGATGCTCTATTGTGCAGTAGCATTTCATTT
AAGATAAGGCTCATATAGTATTACCCAACTAGTTGGTAATGTGATTATGTGGTACCTTGGCTTTAGGTTTTCATTCGCACGGAACACCTT
TTGGCATGCTTAACTTCCTGGTAACACCTTCACCTGCATTGGTTTTCTTTTTCTTTTTTCTTTCTTTTTTTTTTTTTTTTTTTTTTTGAG
TTGTTGTTTGTTTTTAGATCCACAGTACATGAGAATCCTTTTTTGACAAGCCTTGGAAAGCTGACACTGTCTCTTTTTCCTCCCTCTATA
CGAAGGATGTATTTAAATGAATGCTGGTCAGTGGGACATTTTGTCAACTATGGGTATTGGGTGCTTAACTGTCTAATATTGCCATGTGAA
TGTTGTATACGATTGTAAGGCTTATGTCACTAAAGATTTTTATTCTGATTTTTTCATAATCAAAGGTCATATGATACTGTATAGACAAGC
TTTGTAGTGAAGTATAGTAGCAATAATTTCTGTACCTGATCAAGTTTATTGCAGCCTTTCTTTTCCTATTTCTTTTTTTTAAGGGTTAGT
ATTAACAAATGGCAATGAGTAGAAAAGTTAACATGAAGATTTTAGAAGGAGAGAACTTACAGGACACAGATTTGTGATTCTTTGACTGTG
ACACTATTGGATGTGATTCTAAAAGCTTTTATTGAGCATTGTCAAATTTGTAAGCTTCATAGGGATGGACATCATATCTATAATGCCCTT
CTATATGTGCTACCATAGATGTGACATTTTTGACCTTAATATCGTCTTTGAAAATGTTAAATTGAGAAACCTGTTAACTTACATTTTATG
AATTGGCACATTGTATTACTTACTGCAAGAGATATTTCATTTTCAGCACAGTGCAAAAGTTCTTTAAAATGCATATGTCTTTTTTTCTAA
TTCCGTTTTGTTTTAAAGCACATTTTAAATGTAGTTTTCTCATTTAGTAAAAGTTGTCTAATTGATATGAAGCCTGACTGATTTTTTTTT
TCCTTACAGTGAGACATTTAAGCACACATTTTATTCACATAGATACTATGTCCTTGACATATTGAAATGATTCTTTTCTGAAAGTATTCA
TGATCTGCATATGATGTATTAGGTTAGGTCACAAAGGTTTTATCTGAGGTGATTTAAATAACTTCCTGATTGGAGTGTGTAAGCTGAGCG
ATTTCTAATAAAATTTTAGTTGTACACTTTTAGTAGTCATAGTGAAGCAGGTCTAGAAAATAAGCCTTTGGCAGGGAAAAAGGGCAATGT
TGATTAATCTCAGTATTAAACCACATTAATCTGTATCCCATTGTCTGGCTTTTGTAAATTCATCCAGGTCAAGACTAAGTATGTTGGTTA
ATAGGAATCCTTTTTTTTTTTTTTAAAGACTAAATGTGAAAAAATAATCACTACTTAAGCTAATTAATATTGGTCATTAAATTTAAAGGA
TGGAAATTTATCATGTTTAAAAATTATTCAAGCACTCTTAAAACCACTTAAACAGCCTCCAGTCATAAAAATGTGTTCTTTACAAATATT
TGCTTGGCAACACGACTTGAAATAAATAAAACTTTGTTTCTTAGGAGAAAATGATTCTGTAATTCCAGTGTCACTAATTTATATTGTTCT
TTCCTCTGATTTTTTTCAGGTTAGTGATTTTTTTGTATACAATTTAATCCAAATGTTATGACATTCAGAAATCATGAAACACAGTAGATA
TCTGTTATAATGTGGTGTATCACATGGATTATAAAGCAAAGTTATGGTCGATTTCTATTCTTGAAAGAATCAACTACAGTGAATCCTTTG
CATTTGAAGCCTTAACATGCATTGCTTTAATTTTGCCCAGGGACAAATTTTAATAATCAGCAAGACTGGTTTGTGCAAAGCGTTGAGTCA
TCAGGTATTTAGAGCCTAGCCAGCTACCCAGTATCCATGCTGCCATATCCCTTCATTGTAAAAAGTACCTAAACATTCGTGAAATGATTT
TTTTTAGCTGAAAAATGCTGGCAAGAAGAATTTTAAAGCTTAAAATAGGTGGTAAATTTGAAGTATGAGTGTGTTCACGAGAAACATAGG
CTTTTCAAAAAAATTTTTATTCAAGGCAAAGCAAGGAACATCTTGAGATATGTCTCAAGAATATAAAGATGTATTATTTTAAGCCAAGGA
GCTGAAATATATCTCAGTTTATAAATTCAGGTATATTCTTTTTGTCTCCATGGCAACCATAACTTTTGAACCAAAAAAAATTGTTTTTAC
ATCTTTATGCTGAAAATGTGTTTAGATTAGGAATATGGTCGGGCTGAATTTGCTGTTGCTCCCTAACCAAATCCACCTCTTGTTTTCCTT
GTGAGTCCATGGCTAAATCAAAGCTGCCCCTGAGAAGAGACTTAATCCAAGCCTGATTGTACTAGTGGCATCACTTAGAAGTAGGCTTTC
CCTCTTCCTAGTAGATCTCAATGTTTTATAATTCCTTAAAACAGCTGAAAATTGGGACAACATACTTTACGCAATGAACAGTAGTTAAAT
AGGAAATAAACTAGTTCCATATAAGTATACACCTAGAGTTTTAATTACCTTTATAATGTTTCTTAAAAGTGAAACTTAGATACAATTGTG
ATTGGATACTTAGATACTAAGTGAAACTTAGTGTAACAATTTTGATCTGTTAAATTGGATTTTACATGTACATTTGAATGCCAGAATTTC
TAAATAAATCCCCTGGTTAGGAAATTTTAAAAGTCAAAGCTTGTTTTCTTCAACCACTACCTTCTACATTGGTTGACTTAGACCGTAAGC

>65940_65940_6_PLB1-PPP1CB_PLB1_chr2_28719036_ENST00000422425_PPP1CB_chr2_28999716_ENST00000395366_length(amino acids)=333AA_BP=1
MEHSGMGLRPGIFLLELLLLLGQVRGCRPGKIVQMTEAEVRGLCIKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPEA
NYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRFNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGG
LSPDLQSMEQIRRIMRPTDVPDTGLLCDLLWSDPDKDVQGWGENDRGVSFTFGADVVSKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVT

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PLB1-PPP1CB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PLB1-PPP1CB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PLB1-PPP1CB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource