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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:PLCB1-MCM8 (FusionGDB2 ID:65964) |
Fusion Gene Summary for PLCB1-MCM8 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PLCB1-MCM8 | Fusion gene ID: 65964 | Hgene | Tgene | Gene symbol | PLCB1 | MCM8 | Gene ID | 23236 | 84515 |
| Gene name | phospholipase C beta 1 | minichromosome maintenance 8 homologous recombination repair factor | |
| Synonyms | EIEE12|PI-PLC|PLC-154|PLC-I|PLC-beta-1|PLC154|PLCB1A|PLCB1B | C20orf154|POF10|dJ967N21.5 | |
| Cytomap | 20p12.3 | 20p12.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-11-phosphatidyl-D-myo-inositol-4,5-bisphosphateinositoltrisphosphohydrolasemonophosphatidylinositol phosphodiesterasephosphoinositidase Cphosphoinositide phospholipase Cphospholipase C, | DNA helicase MCM8DNA replication licensing factor MCM8MCM8 minichromosome maintenance deficient 8REC homologminichromosome maintenance complex component 8 | |
| Modification date | 20200313 | 20200315 | |
| UniProtAcc | . | Q9UJA3 | |
| Ensembl transtripts involved in fusion gene | ENST00000494924, ENST00000338037, ENST00000378637, ENST00000378641, | ENST00000265187, ENST00000378883, ENST00000378886, ENST00000378896, | |
| Fusion gene scores | * DoF score | 24 X 20 X 10=4800 | 5 X 4 X 4=80 |
| # samples | 22 | 5 | |
| ** MAII score | log2(22/4800*10)=-4.44745897697122 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PLCB1 [Title/Abstract] AND MCM8 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | PLCB1(8703068)-MCM8(5937772), # samples:3 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PLCB1 | GO:0035722 | interleukin-12-mediated signaling pathway | 11743656 |
| Hgene | PLCB1 | GO:0035723 | interleukin-15-mediated signaling pathway | 11743656 |
| Hgene | PLCB1 | GO:0046330 | positive regulation of JNK cascade | 9500449 |
| Hgene | PLCB1 | GO:0070498 | interleukin-1-mediated signaling pathway | 8872139 |
| Tgene | MCM8 | GO:0006974 | cellular response to DNA damage stimulus | 22771115 |
| Fusion gene breakpoints across PLCB1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across MCM8 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | LUSC | TCGA-22-A5C4-01A | PLCB1 | chr20 | 8703068 | - | MCM8 | chr20 | 5937772 | + |
| ChimerDB4 | LUSC | TCGA-22-A5C4-01A | PLCB1 | chr20 | 8703068 | + | MCM8 | chr20 | 5937772 | + |
| ChimerDB4 | LUSC | TCGA-22-A5C4 | PLCB1 | chr20 | 8703068 | + | MCM8 | chr20 | 5937772 | + |
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Fusion Gene ORF analysis for PLCB1-MCM8 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3CDS | ENST00000494924 | ENST00000265187 | PLCB1 | chr20 | 8703068 | + | MCM8 | chr20 | 5937772 | + |
| 3UTR-3CDS | ENST00000494924 | ENST00000378883 | PLCB1 | chr20 | 8703068 | + | MCM8 | chr20 | 5937772 | + |
| 3UTR-3CDS | ENST00000494924 | ENST00000378886 | PLCB1 | chr20 | 8703068 | + | MCM8 | chr20 | 5937772 | + |
| 3UTR-3CDS | ENST00000494924 | ENST00000378896 | PLCB1 | chr20 | 8703068 | + | MCM8 | chr20 | 5937772 | + |
| In-frame | ENST00000338037 | ENST00000265187 | PLCB1 | chr20 | 8703068 | + | MCM8 | chr20 | 5937772 | + |
| In-frame | ENST00000338037 | ENST00000378883 | PLCB1 | chr20 | 8703068 | + | MCM8 | chr20 | 5937772 | + |
| In-frame | ENST00000338037 | ENST00000378886 | PLCB1 | chr20 | 8703068 | + | MCM8 | chr20 | 5937772 | + |
| In-frame | ENST00000338037 | ENST00000378896 | PLCB1 | chr20 | 8703068 | + | MCM8 | chr20 | 5937772 | + |
| In-frame | ENST00000378637 | ENST00000265187 | PLCB1 | chr20 | 8703068 | + | MCM8 | chr20 | 5937772 | + |
| In-frame | ENST00000378637 | ENST00000378883 | PLCB1 | chr20 | 8703068 | + | MCM8 | chr20 | 5937772 | + |
| In-frame | ENST00000378637 | ENST00000378886 | PLCB1 | chr20 | 8703068 | + | MCM8 | chr20 | 5937772 | + |
| In-frame | ENST00000378637 | ENST00000378896 | PLCB1 | chr20 | 8703068 | + | MCM8 | chr20 | 5937772 | + |
| In-frame | ENST00000378641 | ENST00000265187 | PLCB1 | chr20 | 8703068 | + | MCM8 | chr20 | 5937772 | + |
| In-frame | ENST00000378641 | ENST00000378883 | PLCB1 | chr20 | 8703068 | + | MCM8 | chr20 | 5937772 | + |
| In-frame | ENST00000378641 | ENST00000378886 | PLCB1 | chr20 | 8703068 | + | MCM8 | chr20 | 5937772 | + |
| In-frame | ENST00000378641 | ENST00000378896 | PLCB1 | chr20 | 8703068 | + | MCM8 | chr20 | 5937772 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000378641 | PLCB1 | chr20 | 8703068 | + | ENST00000378883 | MCM8 | chr20 | 5937772 | + | 4742 | 2056 | 475 | 3951 | 1158 |
| ENST00000378641 | PLCB1 | chr20 | 8703068 | + | ENST00000378896 | MCM8 | chr20 | 5937772 | + | 4908 | 2056 | 475 | 4092 | 1205 |
| ENST00000378641 | PLCB1 | chr20 | 8703068 | + | ENST00000378886 | MCM8 | chr20 | 5937772 | + | 4251 | 2056 | 475 | 4212 | 1245 |
| ENST00000378641 | PLCB1 | chr20 | 8703068 | + | ENST00000265187 | MCM8 | chr20 | 5937772 | + | 4860 | 2056 | 475 | 4044 | 1189 |
| ENST00000338037 | PLCB1 | chr20 | 8703068 | + | ENST00000378883 | MCM8 | chr20 | 5937772 | + | 4294 | 1608 | 27 | 3503 | 1158 |
| ENST00000338037 | PLCB1 | chr20 | 8703068 | + | ENST00000378896 | MCM8 | chr20 | 5937772 | + | 4460 | 1608 | 27 | 3644 | 1205 |
| ENST00000338037 | PLCB1 | chr20 | 8703068 | + | ENST00000378886 | MCM8 | chr20 | 5937772 | + | 3803 | 1608 | 27 | 3764 | 1245 |
| ENST00000338037 | PLCB1 | chr20 | 8703068 | + | ENST00000265187 | MCM8 | chr20 | 5937772 | + | 4412 | 1608 | 27 | 3596 | 1189 |
| ENST00000378637 | PLCB1 | chr20 | 8703068 | + | ENST00000378883 | MCM8 | chr20 | 5937772 | + | 4270 | 1584 | 3 | 3479 | 1158 |
| ENST00000378637 | PLCB1 | chr20 | 8703068 | + | ENST00000378896 | MCM8 | chr20 | 5937772 | + | 4436 | 1584 | 3 | 3620 | 1205 |
| ENST00000378637 | PLCB1 | chr20 | 8703068 | + | ENST00000378886 | MCM8 | chr20 | 5937772 | + | 3779 | 1584 | 3 | 3740 | 1245 |
| ENST00000378637 | PLCB1 | chr20 | 8703068 | + | ENST00000265187 | MCM8 | chr20 | 5937772 | + | 4388 | 1584 | 3 | 3572 | 1189 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000378641 | ENST00000378883 | PLCB1 | chr20 | 8703068 | + | MCM8 | chr20 | 5937772 | + | 0.00043622 | 0.99956375 |
| ENST00000378641 | ENST00000378896 | PLCB1 | chr20 | 8703068 | + | MCM8 | chr20 | 5937772 | + | 0.000339212 | 0.99966085 |
| ENST00000378641 | ENST00000378886 | PLCB1 | chr20 | 8703068 | + | MCM8 | chr20 | 5937772 | + | 0.001045986 | 0.99895394 |
| ENST00000378641 | ENST00000265187 | PLCB1 | chr20 | 8703068 | + | MCM8 | chr20 | 5937772 | + | 0.000220091 | 0.9997799 |
| ENST00000338037 | ENST00000378883 | PLCB1 | chr20 | 8703068 | + | MCM8 | chr20 | 5937772 | + | 0.000242263 | 0.9997577 |
| ENST00000338037 | ENST00000378896 | PLCB1 | chr20 | 8703068 | + | MCM8 | chr20 | 5937772 | + | 0.000185599 | 0.99981445 |
| ENST00000338037 | ENST00000378886 | PLCB1 | chr20 | 8703068 | + | MCM8 | chr20 | 5937772 | + | 0.000598404 | 0.99940157 |
| ENST00000338037 | ENST00000265187 | PLCB1 | chr20 | 8703068 | + | MCM8 | chr20 | 5937772 | + | 0.000123064 | 0.999877 |
| ENST00000378637 | ENST00000378883 | PLCB1 | chr20 | 8703068 | + | MCM8 | chr20 | 5937772 | + | 0.000231501 | 0.99976856 |
| ENST00000378637 | ENST00000378896 | PLCB1 | chr20 | 8703068 | + | MCM8 | chr20 | 5937772 | + | 0.00017758 | 0.99982244 |
| ENST00000378637 | ENST00000378886 | PLCB1 | chr20 | 8703068 | + | MCM8 | chr20 | 5937772 | + | 0.00058879 | 0.9994112 |
| ENST00000378637 | ENST00000265187 | PLCB1 | chr20 | 8703068 | + | MCM8 | chr20 | 5937772 | + | 0.000117709 | 0.9998822 |
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Fusion Genomic Features for PLCB1-MCM8 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| PLCB1 | chr20 | 8703068 | + | MCM8 | chr20 | 5937771 | + | 9.16E-05 | 0.99990845 |
| PLCB1 | chr20 | 8703068 | + | MCM8 | chr20 | 5937771 | + | 9.16E-05 | 0.99990845 |
| PLCB1 | chr20 | 8703068 | + | MCM8 | chr20 | 5937771 | + | 9.16E-05 | 0.99990845 |
| PLCB1 | chr20 | 8703068 | + | MCM8 | chr20 | 5937771 | + | 9.16E-05 | 0.99990845 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for PLCB1-MCM8 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:8703068/chr20:5937772) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | MCM8 |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR) (PubMed:23401855). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity (PubMed:26215093). Probably by regulating the localization of the MNR complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs (PubMed:23401855). The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression (PubMed:23401855). However, may play a non-essential for DNA replication: may be involved in the activation of the prereplicative complex (pre-RC) during G(1) phase by recruiting CDC6 to the origin recognition complex (ORC) (PubMed:15684404). Probably by regulating HR, plays a key role during gametogenesis (By similarity). Stabilizes MCM9 protein (PubMed:23401855, PubMed:26215093). {ECO:0000250|UniProtKB:Q9CWV1, ECO:0000269|PubMed:15684404, ECO:0000269|PubMed:23401855, ECO:0000269|PubMed:26215093}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PLCB1 | chr20:8703068 | chr20:5937772 | ENST00000338037 | + | 15 | 32 | 316_467 | 527 | 1217.0 | Domain | PI-PLC X-box |
| Hgene | PLCB1 | chr20:8703068 | chr20:5937772 | ENST00000378637 | + | 15 | 32 | 316_467 | 527 | 1174.0 | Domain | PI-PLC X-box |
| Hgene | PLCB1 | chr20:8703068 | chr20:5937772 | ENST00000378641 | + | 15 | 33 | 316_467 | 527 | 2075.6666666666665 | Domain | PI-PLC X-box |
| Tgene | MCM8 | chr20:8703068 | chr20:5937772 | ENST00000265187 | 4 | 19 | 481_490 | 162 | 825.0 | Compositional bias | Note=Thr-rich | |
| Tgene | MCM8 | chr20:8703068 | chr20:5937772 | ENST00000378883 | 4 | 18 | 481_490 | 162 | 794.0 | Compositional bias | Note=Thr-rich | |
| Tgene | MCM8 | chr20:8703068 | chr20:5937772 | ENST00000378886 | 4 | 19 | 481_490 | 162 | 881.0 | Compositional bias | Note=Thr-rich | |
| Tgene | MCM8 | chr20:8703068 | chr20:5937772 | ENST00000378896 | 4 | 19 | 481_490 | 162 | 841.0 | Compositional bias | Note=Thr-rich | |
| Tgene | MCM8 | chr20:8703068 | chr20:5937772 | ENST00000265187 | 4 | 19 | 402_609 | 162 | 825.0 | Domain | Note=MCM | |
| Tgene | MCM8 | chr20:8703068 | chr20:5937772 | ENST00000378883 | 4 | 18 | 402_609 | 162 | 794.0 | Domain | Note=MCM | |
| Tgene | MCM8 | chr20:8703068 | chr20:5937772 | ENST00000378886 | 4 | 19 | 402_609 | 162 | 881.0 | Domain | Note=MCM | |
| Tgene | MCM8 | chr20:8703068 | chr20:5937772 | ENST00000378896 | 4 | 19 | 402_609 | 162 | 841.0 | Domain | Note=MCM | |
| Tgene | MCM8 | chr20:8703068 | chr20:5937772 | ENST00000265187 | 4 | 19 | 454_461 | 162 | 825.0 | Nucleotide binding | ATP | |
| Tgene | MCM8 | chr20:8703068 | chr20:5937772 | ENST00000378883 | 4 | 18 | 454_461 | 162 | 794.0 | Nucleotide binding | ATP | |
| Tgene | MCM8 | chr20:8703068 | chr20:5937772 | ENST00000378886 | 4 | 19 | 454_461 | 162 | 881.0 | Nucleotide binding | ATP | |
| Tgene | MCM8 | chr20:8703068 | chr20:5937772 | ENST00000378896 | 4 | 19 | 454_461 | 162 | 841.0 | Nucleotide binding | ATP |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PLCB1 | chr20:8703068 | chr20:5937772 | ENST00000338037 | + | 15 | 32 | 540_656 | 527 | 1217.0 | Domain | PI-PLC Y-box |
| Hgene | PLCB1 | chr20:8703068 | chr20:5937772 | ENST00000338037 | + | 15 | 32 | 656_786 | 527 | 1217.0 | Domain | C2 |
| Hgene | PLCB1 | chr20:8703068 | chr20:5937772 | ENST00000378637 | + | 15 | 32 | 540_656 | 527 | 1174.0 | Domain | PI-PLC Y-box |
| Hgene | PLCB1 | chr20:8703068 | chr20:5937772 | ENST00000378637 | + | 15 | 32 | 656_786 | 527 | 1174.0 | Domain | C2 |
| Hgene | PLCB1 | chr20:8703068 | chr20:5937772 | ENST00000378641 | + | 15 | 33 | 540_656 | 527 | 2075.6666666666665 | Domain | PI-PLC Y-box |
| Hgene | PLCB1 | chr20:8703068 | chr20:5937772 | ENST00000378641 | + | 15 | 33 | 656_786 | 527 | 2075.6666666666665 | Domain | C2 |
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Fusion Gene Sequence for PLCB1-MCM8 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >65964_65964_1_PLCB1-MCM8_PLCB1_chr20_8703068_ENST00000338037_MCM8_chr20_5937772_ENST00000265187_length(transcript)=4412nt_BP=1608nt GGCCGCCCGGAGCCCAGATGAGCCCAGATGGCCGGGGCTCAACCCGGAGTGCACGCCTTGCAACTCAAGCCCGTGTGCGTGTCCGACAGC CTCAAGAAGGGCACCAAATTCGTCAAGTGGGATGATGACTCAACTATTGTTACTCCAATTATTTTGAGGACTGACCCTCAGGGATTTTTC TTTTACTGGACAGATCAAAACAAGGAGACAGAGCTACTGGATCTCAGCCTTGTCAAAGATGCCAGATGTGGGAGACACGCCAAAGCTCCC AAGGACCCCAAATTACGTGAACTTTTGGATGTGGGGAACATCGGGCGCCTGGAGCAGCGCATGATCACAGTGGTGTATGGGCCTGACCTC GTGAACATCTCCCATTTGAATCTCGTGGCTTTCCAAGAAGAAGTGGCCAAGGAATGGACAAATGAGGTTTTCAGTTTGGCAACAAACCTG CTGGCCCAAAACATGTCCAGGGATGCATTTCTGGAAAAAGCCTATACTAAACTTAAGCTGCAAGTCACTCCAGAAGGGCGTATTCCTCTC AAAAACATATATCGCTTGTTTTCAGCAGATCGGAAGCGAGTTGAAACTGCTTTAGAGGCTTGTAGTCTTCCATCTTCAAGGAATGATTCA ATACCTCAAGAAGATTTCACTCCAGAAGTGTACAGAGTTTTCCTCAACAACCTTTGCCCTCGACCTGAAATTGATAACATCTTTTCAGAA TTTGGTGCAAAAAGCAAACCATATCTTACCGTTGATCAGATGATGGATTTTATCAACCTTAAGCAGCGAGATCCTCGGCTTAATGAAATA CTTTATCCACCTCTAAAACAAGAGCAAGTCCAAGTATTGATTGAGAAGTATGAACCCAACAACAGCCTCGCCAGAAAAGGACAAATATCA GTGGATGGGTTCATGCGCTATCTGAGTGGAGAAGAAAACGGAGTCGTTTCACCTGAGAAACTGGATTTGAATGAAGACATGTCTCAGCCC CTTTCTCACTATTTCATTAATTCCTCGCACAACACCTACCTCACAGCTGGCCAACTGGCTGGAAACTCCTCTGTTGAGATGTATCGCCAA GTGCTCCTGTCTGGTTGTCGCTGTGTGGAGCTGGACTGCTGGAAGGGACGGACTGCAGAAGAGGAACCTGTCATCACCCATGGCTTCACC ATGACAACTGAAATATCTTTCAAGGAAGTGATAGAAGCAATTGCGGAGTGTGCATTTAAGACTTCACCTTTTCCAATTCTCCTTTCGTTT GAGAACCATGTGGATTCCCCAAAGCAGCAAGCCAAGATGGCGGAGTACTGCCGACTGATCTTTGGGGATGCCCTTCTCATGGAGCCCCTG GAAAAATATCCACTGGAATCTGGAGTTCCTCTTCCAAGCCCTATGGATTTAATGTATAAAATTTTGGTGAAAAATAAGAAGAAATCACAC AAGTCATCAGAAGGAAGCGGCAAAAAGAAGCTCTCAGAACAAGCCTCCAACACCTACAGTGACTCCTCCAGCATGTTCGAGCCCTCATCC CCAGGAGCCGGAGAAGCTGATACGGAAAGTGACGACGACGATGATGATGATGACTGTAAAAAATCTTCAATGGATGAGGTGTTAACTAAG GACCTTGAAAGGCATGCAGCTGAGTTACAAGCCCAGGAAGGATTGTCTAATGATGGAGAAACAATGGTAAATGTGCCACATATTCATGCA AGGGTGTACAACTATGAGCCTTTGACACAGCTCAAGAATGTCAGAGCAAATTACTATGGAAAATACATTGCTCTAAGAGGGACAGTGGTT CGTGTCAGTAATATAAAGCCTCTTTGCACCAAGATGGCTTTTCTTTGTGCTGCATGTGGAGAAATTCAGAGCTTTCCTCTTCCAGATGGA AAATACAGTCTTCCCACAAAGTGTCCTGTGCCTGTGTGTCGAGGCAGGTCATTTACTGCTCTCCGCAGCTCTCCTCTCACAGTTACGATG GACTGGCAGTCAATCAAAATCCAGGAATTGATGTCTGATGATCAGAGAGAAGCAGGTCGGATTCCACGAACAATAGAATGTGAGCTTGTT CATGATCTTGTGGATAGCTGTGTCCCGGGAGACACAGTGACTATTACTGGAATTGTCAAAGTCTCAAATGCGGAAGAAGCAAATTCTATT AGTAATAGCAAAGGACAGAAAACAAAGAGTTCTGAGGATGGGTGTAAGCATGGAATGTTGATGGAGTTCTCACTTAAAGACCTTTATGCC ATCCAAGAGATTCAAGCTGAAGAAAACCTGTTTAAACTCATTGTCAACTCGCTTTGCCCTGTCATTTTTGGTCATGAACTTGTTAAAGCA GGTTTGGCATTAGCACTCTTTGGAGGAAGCCAGAAATACGCAGATGACAAAAACAGAATTCCAATTCGGGGAGACCCCCACATCCTTGTT GTTGGAGATCCAGGCCTAGGAAAAAGTCAAATGCTACAGGCAGCGTGCAATGTTGCCCCACGTGGCGTGTATGTTTGTGGTAACACCACG ACCACCTCTGGTCTGACGGTAACTCTTTCAAAAGATAGTTCCTCTGGAGATTTTGCTTTGGAAGCTGGTGCCCTGGTACTTGGTGATCAA GGTATTTGTGGAATCGATGAATTTGATAAGATGGGGAATCAACATCAAGCCTTGTTGGAAGCCATGGAGCAGCAAAGTATTAGTCTTGCT AAGGCTGGTGTGGTTTGTAGCCTTCCTGCAAGAACTTCCATTATTGCTGCTGCAAATCCAGTTGGAGGACATTACAATAAAGCCAAAACA GTTTCTGAGAATTTAAAAATGGGGAGTGCACTACTATCCAGATTTGATTTGGTCTTTATCCTGTTAGATACTCCAAATGAGCATCATGAT CACTTACTCTCTGAACATGTGATTGCAATAAGAGCTGGAAAGCAGAGAACCATTAGCAGTGCCACAGTAGCTCGTATGAATAGTCAAGAT TCAAATACTTCCGTACTTGAAGTAGTTTCTGAGAAGCCATTATCAGAAAGACTAAAGGTGGTTCCTGGAGAAACAATAGATCCCATTCCC CACCAGCTATTGAGAAAGTACATTGGCTATGCTCGGCAGTATGTGTACCCAAGGCTATCCACAGAAGCTGCTCGAGTTCTTCAAGATTTT TACCTTGAGCTCCGGAAACAGAGCCAGAGGTTAAATAGCTCACCAATCACTACCAGGCAGCTGGAATCTTTGATTCGTCTGACAGAGGCA CGAGCAAGGTTGGAATTGAGAGAGGAAGCAACCAAAGAAGACGCTGAGGATATAGTGGAAATTATGAAATATAGCATGCTAGGAACTTAC TCTGATGAATTTGGGAACCTAGATTTTGAGCGATCCCAGCATGGTTCTGGAATGAGCAACAGGTCAACAGCGAAAAGATTTATTTCTGCT CTCAACAACGTTGCTGAAAGAACTTATAATAATATATTTCAATTTCATCAACTTCGGCAGATTGCCAAAGAACTAAACATTCAGGTTGCT GATTTTGAAAATTTTATTGGATCACTAAATGACCAGGGTTACCTCTTGAAAAAAGGCCCAAAAGTTTACCAGCTTCAAACTATGTAAAAG GACTTCACCAAGTTAGGGCCTCCTGGGTTTATTGCAGATTAAAGCCATCTCAGTGAAGATATGCGTGCACGCACAGACAGACAGACACAC ACACACACACACACACACACACACACACACACACACACAGTCAAATACTGTTCTCTGAAAAATGATGTCCCAAAAGTATTATAATAGGAA AAAAGCATTAAATATAATAAACTAATTTAAGAAGTGATAAAGTCTCCAGATGCAGTAGCTCACACTGTAATCACAGTGACTCAGGAGGCT GAGGTGAGAGGATTCCTTGAGGCCAGGGTTCGAGACCAACCTTGGGCAACATAGCAAGACCCCATTTCTTAAAAAAAAAAAAAAAAAATT TAAACTTAGCTGGGTATGGTGGCACATGCCTATAGTCTCAGCTACTTGTGAGGCTGAGGCAGGAGGATTCTTTGAGCCCAGGAGTTTGAG GTTACAGTGAGCCACAATCACACCAATCACTGCACTCCAGCCTGGGCAATAAAGTAACTCTTGACTCAAAAAAATAAAAAAAATTGTAGT GGTAGCCATGTGTTAATTGTTAAATAAATTCTCCAAAGGGCTAAAAGTAAATTACTTATAAATTTTTTATAGTTGTATTTTTGACCTGCC TTTTATATGTATGAATATTTCATAGTTTTGCATATCAGATGTAGGCATACAGACAAATACATAAACCAATGAATATATTACATATTCTGT GTTCCAATAAAACTTTATTTATGGACACTAAAATTTGAATTTCATAAAATTTTCCCATGTCAAGAATACAAAATACTTGAGTTTTGTTTT >65964_65964_1_PLCB1-MCM8_PLCB1_chr20_8703068_ENST00000338037_MCM8_chr20_5937772_ENST00000265187_length(amino acids)=1189AA_BP=527 MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKETELLDLSLVKDARCGRHAKAPKDPKLRELL DVGNIGRLEQRMITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSA DRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQ VQVLIEKYEPNNSLARKGQISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGV PLPSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSSSMFEPSSPGAGEADTESDDDDDDDDCKKSSMDEVLTKDLERHAAEL QAQEGLSNDGETMVNVPHIHARVYNYEPLTQLKNVRANYYGKYIALRGTVVRVSNIKPLCTKMAFLCAACGEIQSFPLPDGKYSLPTKCP VPVCRGRSFTALRSSPLTVTMDWQSIKIQELMSDDQREAGRIPRTIECELVHDLVDSCVPGDTVTITGIVKVSNAEEANSISNSKGQKTK SSEDGCKHGMLMEFSLKDLYAIQEIQAEENLFKLIVNSLCPVIFGHELVKAGLALALFGGSQKYADDKNRIPIRGDPHILVVGDPGLGKS QMLQAACNVAPRGVYVCGNTTTTSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQALLEAMEQQSISLAKAGVVCSLP ARTSIIAAANPVGGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEHHDHLLSEHVIAIRAGKQRTISSATVARMNSQDSNTSVLEVV SEKPLSERLKVVPGETIDPIPHQLLRKYIGYARQYVYPRLSTEAARVLQDFYLELRKQSQRLNSSPITTRQLESLIRLTEARARLELREE ATKEDAEDIVEIMKYSMLGTYSDEFGNLDFERSQHGSGMSNRSTAKRFISALNNVAERTYNNIFQFHQLRQIAKELNIQVADFENFIGSL -------------------------------------------------------------- >65964_65964_2_PLCB1-MCM8_PLCB1_chr20_8703068_ENST00000338037_MCM8_chr20_5937772_ENST00000378883_length(transcript)=4294nt_BP=1608nt GGCCGCCCGGAGCCCAGATGAGCCCAGATGGCCGGGGCTCAACCCGGAGTGCACGCCTTGCAACTCAAGCCCGTGTGCGTGTCCGACAGC CTCAAGAAGGGCACCAAATTCGTCAAGTGGGATGATGACTCAACTATTGTTACTCCAATTATTTTGAGGACTGACCCTCAGGGATTTTTC TTTTACTGGACAGATCAAAACAAGGAGACAGAGCTACTGGATCTCAGCCTTGTCAAAGATGCCAGATGTGGGAGACACGCCAAAGCTCCC AAGGACCCCAAATTACGTGAACTTTTGGATGTGGGGAACATCGGGCGCCTGGAGCAGCGCATGATCACAGTGGTGTATGGGCCTGACCTC GTGAACATCTCCCATTTGAATCTCGTGGCTTTCCAAGAAGAAGTGGCCAAGGAATGGACAAATGAGGTTTTCAGTTTGGCAACAAACCTG CTGGCCCAAAACATGTCCAGGGATGCATTTCTGGAAAAAGCCTATACTAAACTTAAGCTGCAAGTCACTCCAGAAGGGCGTATTCCTCTC AAAAACATATATCGCTTGTTTTCAGCAGATCGGAAGCGAGTTGAAACTGCTTTAGAGGCTTGTAGTCTTCCATCTTCAAGGAATGATTCA ATACCTCAAGAAGATTTCACTCCAGAAGTGTACAGAGTTTTCCTCAACAACCTTTGCCCTCGACCTGAAATTGATAACATCTTTTCAGAA TTTGGTGCAAAAAGCAAACCATATCTTACCGTTGATCAGATGATGGATTTTATCAACCTTAAGCAGCGAGATCCTCGGCTTAATGAAATA CTTTATCCACCTCTAAAACAAGAGCAAGTCCAAGTATTGATTGAGAAGTATGAACCCAACAACAGCCTCGCCAGAAAAGGACAAATATCA GTGGATGGGTTCATGCGCTATCTGAGTGGAGAAGAAAACGGAGTCGTTTCACCTGAGAAACTGGATTTGAATGAAGACATGTCTCAGCCC CTTTCTCACTATTTCATTAATTCCTCGCACAACACCTACCTCACAGCTGGCCAACTGGCTGGAAACTCCTCTGTTGAGATGTATCGCCAA GTGCTCCTGTCTGGTTGTCGCTGTGTGGAGCTGGACTGCTGGAAGGGACGGACTGCAGAAGAGGAACCTGTCATCACCCATGGCTTCACC ATGACAACTGAAATATCTTTCAAGGAAGTGATAGAAGCAATTGCGGAGTGTGCATTTAAGACTTCACCTTTTCCAATTCTCCTTTCGTTT GAGAACCATGTGGATTCCCCAAAGCAGCAAGCCAAGATGGCGGAGTACTGCCGACTGATCTTTGGGGATGCCCTTCTCATGGAGCCCCTG GAAAAATATCCACTGGAATCTGGAGTTCCTCTTCCAAGCCCTATGGATTTAATGTATAAAATTTTGGTGAAAAATAAGAAGAAATCACAC AAGTCATCAGAAGGAAGCGGCAAAAAGAAGCTCTCAGAACAAGCCTCCAACACCTACAGTGACTCCTCCAGCATGTTCGAGCCCTCATCC CCAGGAGCCGGAGAAGCTGATACGGAAAGTGACGACGACGATGATGATGATGACTGTAAAAAATCTTCAATGGATGAGGTGTTAACTAAG GACCTTGAAAGGCATGCAGCTGAGTTACAAGCCCAGGAAGGATTGTCTAATGATGGAGAAACAATGGTAAATGTGCCACATATTCATGCA AGGGTGTACAACTATGAGCCTTTGACACAGCTCAAGAATGTCAGAGCAAATTACTATGGAAAATACATTGCTCTAAGAGGGACAGTGGTT CGTGTCAGTAATATAAAGCCTCTTTGCACCAAGATGGCTTTTCTTTGTGCTGCATGTGGAGAAATTCAGAGCTTTCCTCTTCCAGATGGA AAATACAGTCTTCCCACAAAGTGTCCTGTGCCTGTGTGTCGAGGCAGGTCATTTACTGCTCTCCGCAGCTCTCCTCTCACAGTTACGATG GACTGGCAGTCAATCAAAATCCAGGAATTGATGTCTGATGATCAGAGAGAAGCAGGTCGGATTCCACGAACAATAGAATGTGAGCTTGTT CATGATCTTGTGGATAGCTGTGTCCCGGGAGACACAGTGACTATTACTGGAATTGTCAAAGTCTCAAATGCGGAAGAAGGTTCTCGAAAT AAGAATGACAAGTGTATGTTCCTTTTGTATATTGAAGCAAATTCTATTAGTAATAGCAAAGGACAGAAAACAAAGAGTTCTGAGGATGGG TGTAAGCATGGAATGTTGATGGAGTTCTCACTTAAAGACCTTTATGCCATCCAAGAGATTCAAGCTGAAGAAAACCTGTTTAAACTCATT GTCAACTCGCTTTGCCCTGTCATTTTTGGTCATGAAGCAGCGTGCAATGTTGCCCCACGTGGCGTGTATGTTTGTGGTAACACCACGACC ACCTCTGGTCTGACGGTAACTCTTTCAAAAGATAGTTCCTCTGGAGATTTTGCTTTGGAAGCTGGTGCCCTGGTACTTGGTGATCAAGGT ATTTGTGGAATCGATGAATTTGATAAGATGGGGAATCAACATCAAGCCTTGTTGGAAGCCATGGAGCAGCAAAGTATTAGTCTTGCTAAG GCTGGTGTGGTTTGTAGCCTTCCTGCAAGAACTTCCATTATTGCTGCTGCAAATCCAGTTGGAGGACATTACAATAAAGCCAAAACAGTT TCTGAGAATTTAAAAATGGGGAGTGCACTACTATCCAGATTTGATTTGGTCTTTATCCTGTTAGATACTCCAAATGAGCATCATGATCAC TTACTCTCTGAACATGTGATTGCAATAAGAGCTGGAAAGCAGAGAACCATTAGCAGTGCCACAGTAGCTCGTATGAATAGTCAAGATTCA AATACTTCCGTACTTGAAGTAGTTTCTGAGAAGCCATTATCAGAAAGACTAAAGGTGGTTCCTGGAGAAACAATAGATCCCATTCCCCAC CAGCTATTGAGAAAGTACATTGGCTATGCTCGGCAGTATGTGTACCCAAGGCTATCCACAGAAGCTGCTCGAGTTCTTCAAGATTTTTAC CTTGAGCTCCGGAAACAGAGCCAGAGGTTAAATAGCTCACCAATCACTACCAGGCAGCTGGAATCTTTGATTCGTCTGACAGAGGCACGA GCAAGGTTGGAATTGAGAGAGGAAGCAACCAAAGAAGACGCTGAGGATATAGTGGAAATTATGAAATATAGCATGCTAGGAACTTACTCT GATGAATTTGGGAACCTAGATTTTGAGCGATCCCAGCATGGTTCTGGAATGAGCAACAGGTCAACAGCGAAAAGATTTATTTCTGCTCTC AACAACGTTGCTGAAAGAACTTATAATAATATATTTCAATTTCATCAACTTCGGCAGATTGCCAAAGAACTAAACATTCAGGTTGCTGAT TTTGAAAATTTTATTGGATCACTAAATGACCAGGGTTACCTCTTGAAAAAAGGCCCAAAAGTTTACCAGCTTCAAACTATGTAAAAGGAC TTCACCAAGTTAGGGCCTCCTGGGTTTATTGCAGATTAAAGCCATCTCAGTGAAGATATGCGTGCACGCACAGACAGACAGACACACACA CACACACACACACACACACACACACACACACACACAGTCAAATACTGTTCTCTGAAAAATGATGTCCCAAAAGTATTATAATAGGAAAAA AGCATTAAATATAATAAACTAATTTAAGAAGTGATAAAGTCTCCAGATGCAGTAGCTCACACTGTAATCACAGTGACTCAGGAGGCTGAG GTGAGAGGATTCCTTGAGGCCAGGGTTCGAGACCAACCTTGGGCAACATAGCAAGACCCCATTTCTTAAAAAAAAAAAAAAAAAATTTAA ACTTAGCTGGGTATGGTGGCACATGCCTATAGTCTCAGCTACTTGTGAGGCTGAGGCAGGAGGATTCTTTGAGCCCAGGAGTTTGAGGTT ACAGTGAGCCACAATCACACCAATCACTGCACTCCAGCCTGGGCAATAAAGTAACTCTTGACTCAAAAAAATAAAAAAAATTGTAGTGGT AGCCATGTGTTAATTGTTAAATAAATTCTCCAAAGGGCTAAAAGTAAATTACTTATAAATTTTTTATAGTTGTATTTTTGACCTGCCTTT TATATGTATGAATATTTCATAGTTTTGCATATCAGATGTAGGCATACAGACAAATACATAAACCAATGAATATATTACATATTCTGTGTT >65964_65964_2_PLCB1-MCM8_PLCB1_chr20_8703068_ENST00000338037_MCM8_chr20_5937772_ENST00000378883_length(amino acids)=1158AA_BP=527 MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKETELLDLSLVKDARCGRHAKAPKDPKLRELL DVGNIGRLEQRMITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSA DRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQ VQVLIEKYEPNNSLARKGQISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGV PLPSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSSSMFEPSSPGAGEADTESDDDDDDDDCKKSSMDEVLTKDLERHAAEL QAQEGLSNDGETMVNVPHIHARVYNYEPLTQLKNVRANYYGKYIALRGTVVRVSNIKPLCTKMAFLCAACGEIQSFPLPDGKYSLPTKCP VPVCRGRSFTALRSSPLTVTMDWQSIKIQELMSDDQREAGRIPRTIECELVHDLVDSCVPGDTVTITGIVKVSNAEEGSRNKNDKCMFLL YIEANSISNSKGQKTKSSEDGCKHGMLMEFSLKDLYAIQEIQAEENLFKLIVNSLCPVIFGHEAACNVAPRGVYVCGNTTTTSGLTVTLS KDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSA LLSRFDLVFILLDTPNEHHDHLLSEHVIAIRAGKQRTISSATVARMNSQDSNTSVLEVVSEKPLSERLKVVPGETIDPIPHQLLRKYIGY ARQYVYPRLSTEAARVLQDFYLELRKQSQRLNSSPITTRQLESLIRLTEARARLELREEATKEDAEDIVEIMKYSMLGTYSDEFGNLDFE -------------------------------------------------------------- >65964_65964_3_PLCB1-MCM8_PLCB1_chr20_8703068_ENST00000338037_MCM8_chr20_5937772_ENST00000378886_length(transcript)=3803nt_BP=1608nt GGCCGCCCGGAGCCCAGATGAGCCCAGATGGCCGGGGCTCAACCCGGAGTGCACGCCTTGCAACTCAAGCCCGTGTGCGTGTCCGACAGC CTCAAGAAGGGCACCAAATTCGTCAAGTGGGATGATGACTCAACTATTGTTACTCCAATTATTTTGAGGACTGACCCTCAGGGATTTTTC TTTTACTGGACAGATCAAAACAAGGAGACAGAGCTACTGGATCTCAGCCTTGTCAAAGATGCCAGATGTGGGAGACACGCCAAAGCTCCC AAGGACCCCAAATTACGTGAACTTTTGGATGTGGGGAACATCGGGCGCCTGGAGCAGCGCATGATCACAGTGGTGTATGGGCCTGACCTC GTGAACATCTCCCATTTGAATCTCGTGGCTTTCCAAGAAGAAGTGGCCAAGGAATGGACAAATGAGGTTTTCAGTTTGGCAACAAACCTG CTGGCCCAAAACATGTCCAGGGATGCATTTCTGGAAAAAGCCTATACTAAACTTAAGCTGCAAGTCACTCCAGAAGGGCGTATTCCTCTC AAAAACATATATCGCTTGTTTTCAGCAGATCGGAAGCGAGTTGAAACTGCTTTAGAGGCTTGTAGTCTTCCATCTTCAAGGAATGATTCA ATACCTCAAGAAGATTTCACTCCAGAAGTGTACAGAGTTTTCCTCAACAACCTTTGCCCTCGACCTGAAATTGATAACATCTTTTCAGAA TTTGGTGCAAAAAGCAAACCATATCTTACCGTTGATCAGATGATGGATTTTATCAACCTTAAGCAGCGAGATCCTCGGCTTAATGAAATA CTTTATCCACCTCTAAAACAAGAGCAAGTCCAAGTATTGATTGAGAAGTATGAACCCAACAACAGCCTCGCCAGAAAAGGACAAATATCA GTGGATGGGTTCATGCGCTATCTGAGTGGAGAAGAAAACGGAGTCGTTTCACCTGAGAAACTGGATTTGAATGAAGACATGTCTCAGCCC CTTTCTCACTATTTCATTAATTCCTCGCACAACACCTACCTCACAGCTGGCCAACTGGCTGGAAACTCCTCTGTTGAGATGTATCGCCAA GTGCTCCTGTCTGGTTGTCGCTGTGTGGAGCTGGACTGCTGGAAGGGACGGACTGCAGAAGAGGAACCTGTCATCACCCATGGCTTCACC ATGACAACTGAAATATCTTTCAAGGAAGTGATAGAAGCAATTGCGGAGTGTGCATTTAAGACTTCACCTTTTCCAATTCTCCTTTCGTTT GAGAACCATGTGGATTCCCCAAAGCAGCAAGCCAAGATGGCGGAGTACTGCCGACTGATCTTTGGGGATGCCCTTCTCATGGAGCCCCTG GAAAAATATCCACTGGAATCTGGAGTTCCTCTTCCAAGCCCTATGGATTTAATGTATAAAATTTTGGTGAAAAATAAGAAGAAATCACAC AAGTCATCAGAAGGAAGCGGCAAAAAGAAGCTCTCAGAACAAGCCTCCAACACCTACAGTGACTCCTCCAGCATGTTCGAGCCCTCATCC CCAGGAGCCGGAGAAGCTGATACGGAAAGTGACGACGACGATGATGATGATGACTGTAAAAAATCTTCAATGGATGAGGTGTTAACTAAG GACCTTGAAAGGCATGCAGCTGAGTTACAAGCCCAGGAAGGATTGTCTAATGATGGAGAAACAATGGTAAATGTGCCACATATTCATGCA AGGGTGTACAACTATGAGCCTTTGACACAGCTCAAGAATGTCAGAGCAAATTACTATGGAAAATACATTGCTCTAAGAGGGACAGTGGTT CGTGTCAGTAATATAAAGCCTCTTTGCACCAAGATGGCTTTTCTTTGTGCTGCATGTGGAGAAATTCAGAGCTTTCCTCTTCCAGATGGA AAATACAGTCTTCCCACAAAGTGTCCTGTGCCTGTGTGTCGAGGCAGGTCATTTACTGCTCTCCGCAGCTCTCCTCTCACAGTTACGATG GACTGGCAGTCAATCAAAATCCAGGAATTGATGTCTGATGATCAGAGAGAAGCAGGTCGGATTCCACGAACAATAGAATGTGAGCTTGTT CATGATCTTGTGGATAGCTGTGTCCCGGGAGACACAGTGACTATTACTGGAATTGTCAAAGTCTCAAATGCGGAAGAAGGTTCTCGAAAT AAGAATGACAAGTGTATGTTCCTTTTGTATATTGAAGCAAATTCTATTAGTAATAGCAAAGGACAGAAAACAAAGAGTTCTGAGGATGGG TGTAAGCATGGAATGTTGATGGAGTTCTCACTTAAAGACCTTTATGCCATCCAAGAGATTCAAGCTGAAGAAAACCTGTTTAAACTCATT GTCAAATGGAGTCTTGCTCTGTCGCCCAGGCTAGAGTACAGTGGTGCGATCTCAGCTCACTGCAACCTCCACCTCCCAAGTTCAAACAGT TCTCCCACCTCAGCCTGCCGAGTAGCTGGGACTACAGGCATGCGCCACCAGACCCAGCTACTTTTGCTTGTTAAAGCAGGTTTGGCATTA GCACTCTTTGGAGGAAGCCAGAAATACGCAGATGACAAAAACAGAATTCCAATTCGGGGAGACCCCCACATCCTTGTTGTTGGAGATCCA GGCCTAGGAAAAAGTCAAATGCTACAGGCAGCGTGCAATGTTGCCCCACGTGGCGTGTATGTTTGTGGTAACACCACGACCACCTCTGGT CTGACGGTAACTCTTTCAAAAGATAGTTCCTCTGGAGATTTTGCTTTGGAAGCTGGTGCCCTGGTACTTGGTGATCAAGGTATTTGTGGA ATCGATGAATTTGATAAGATGGGGAATCAACATCAAGCCTTGTTGGAAGCCATGGAGCAGCAAAGTATTAGTCTTGCTAAGGCTGGTGTG GTTTGTAGCCTTCCTGCAAGAACTTCCATTATTGCTGCTGCAAATCCAGTTGGAGGACATTACAATAAAGCCAAAACAGTTTCTGAGAAT TTAAAAATGGGGAGTGCACTACTATCCAGATTTGATTTGGTCTTTATCCTGTTAGATACTCCAAATGAGCATCATGATCACTTACTCTCT GAACATGTGATTGCAATAAGAGCTGGAAAGCAGAGAACCATTAGCAGTGCCACAGTAGCTCGTATGAATAGTCAAGATTCAAATACTTCC GTACTTGAAGTAGTTTCTGAGAAGCCATTATCAGAAAGACTAAAGGTGGTTCCTGGAGAAACAATAGATCCCATTCCCCACCAGCTATTG AGAAAGTACATTGGCTATGCTCGGCAGTATGTGTACCCAAGGCTATCCACAGAAGCTGCTCGAGTTCTTCAAGATTTTTACCTTGAGCTC CGGAAACAGAGCCAGAGGTTAAATAGCTCACCAATCACTACCAGGCAGCTGGAATCTTTGATTCGTCTGACAGAGGCACGAGCAAGGTTG GAATTGAGAGAGGAAGCAACCAAAGAAGACGCTGAGGATATAGTGGAAATTATGAAATATAGCATGCTAGGAACTTACTCTGATGAATTT GGGAACCTAGATTTTGAGCGATCCCAGCATGGTTCTGGAATGAGCAACAGGTCAACAGCGAAAAGATTTATTTCTGCTCTCAACAACGTT GCTGAAAGAACTTATAATAATATATTTCAATTTCATCAACTTCGGCAGATTGCCAAAGAACTAAACATTCAGGTTGCTGATTTTGAAAAT TTTATTGGATCACTAAATGACCAGGGTTACCTCTTGAAAAAAGGCCCAAAAGTTTACCAGCTTCAAACTATGTAAAAGGACTTCACCAAG >65964_65964_3_PLCB1-MCM8_PLCB1_chr20_8703068_ENST00000338037_MCM8_chr20_5937772_ENST00000378886_length(amino acids)=1245AA_BP=774 MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKETELLDLSLVKDARCGRHAKAPKDPKLRELL DVGNIGRLEQRMITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSA DRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQ VQVLIEKYEPNNSLARKGQISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGV PLPSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSSSMFEPSSPGAGEADTESDDDDDDDDCKKSSMDEVLTKDLERHAAEL QAQEGLSNDGETMVNVPHIHARVYNYEPLTQLKNVRANYYGKYIALRGTVVRVSNIKPLCTKMAFLCAACGEIQSFPLPDGKYSLPTKCP VPVCRGRSFTALRSSPLTVTMDWQSIKIQELMSDDQREAGRIPRTIECELVHDLVDSCVPGDTVTITGIVKVSNAEEGSRNKNDKCMFLL YIEANSISNSKGQKTKSSEDGCKHGMLMEFSLKDLYAIQEIQAEENLFKLIVKWSLALSPRLEYSGAISAHCNLHLPSSNSSPTSACRVA GTTGMRHQTQLLLLVKAGLALALFGGSQKYADDKNRIPIRGDPHILVVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTTSGLTVTLSKDS SSGDFALEAGALVLGDQGICGIDEFDKMGNQHQALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALLS RFDLVFILLDTPNEHHDHLLSEHVIAIRAGKQRTISSATVARMNSQDSNTSVLEVVSEKPLSERLKVVPGETIDPIPHQLLRKYIGYARQ YVYPRLSTEAARVLQDFYLELRKQSQRLNSSPITTRQLESLIRLTEARARLELREEATKEDAEDIVEIMKYSMLGTYSDEFGNLDFERSQ -------------------------------------------------------------- >65964_65964_4_PLCB1-MCM8_PLCB1_chr20_8703068_ENST00000338037_MCM8_chr20_5937772_ENST00000378896_length(transcript)=4460nt_BP=1608nt GGCCGCCCGGAGCCCAGATGAGCCCAGATGGCCGGGGCTCAACCCGGAGTGCACGCCTTGCAACTCAAGCCCGTGTGCGTGTCCGACAGC CTCAAGAAGGGCACCAAATTCGTCAAGTGGGATGATGACTCAACTATTGTTACTCCAATTATTTTGAGGACTGACCCTCAGGGATTTTTC TTTTACTGGACAGATCAAAACAAGGAGACAGAGCTACTGGATCTCAGCCTTGTCAAAGATGCCAGATGTGGGAGACACGCCAAAGCTCCC AAGGACCCCAAATTACGTGAACTTTTGGATGTGGGGAACATCGGGCGCCTGGAGCAGCGCATGATCACAGTGGTGTATGGGCCTGACCTC GTGAACATCTCCCATTTGAATCTCGTGGCTTTCCAAGAAGAAGTGGCCAAGGAATGGACAAATGAGGTTTTCAGTTTGGCAACAAACCTG CTGGCCCAAAACATGTCCAGGGATGCATTTCTGGAAAAAGCCTATACTAAACTTAAGCTGCAAGTCACTCCAGAAGGGCGTATTCCTCTC AAAAACATATATCGCTTGTTTTCAGCAGATCGGAAGCGAGTTGAAACTGCTTTAGAGGCTTGTAGTCTTCCATCTTCAAGGAATGATTCA ATACCTCAAGAAGATTTCACTCCAGAAGTGTACAGAGTTTTCCTCAACAACCTTTGCCCTCGACCTGAAATTGATAACATCTTTTCAGAA TTTGGTGCAAAAAGCAAACCATATCTTACCGTTGATCAGATGATGGATTTTATCAACCTTAAGCAGCGAGATCCTCGGCTTAATGAAATA CTTTATCCACCTCTAAAACAAGAGCAAGTCCAAGTATTGATTGAGAAGTATGAACCCAACAACAGCCTCGCCAGAAAAGGACAAATATCA GTGGATGGGTTCATGCGCTATCTGAGTGGAGAAGAAAACGGAGTCGTTTCACCTGAGAAACTGGATTTGAATGAAGACATGTCTCAGCCC CTTTCTCACTATTTCATTAATTCCTCGCACAACACCTACCTCACAGCTGGCCAACTGGCTGGAAACTCCTCTGTTGAGATGTATCGCCAA GTGCTCCTGTCTGGTTGTCGCTGTGTGGAGCTGGACTGCTGGAAGGGACGGACTGCAGAAGAGGAACCTGTCATCACCCATGGCTTCACC ATGACAACTGAAATATCTTTCAAGGAAGTGATAGAAGCAATTGCGGAGTGTGCATTTAAGACTTCACCTTTTCCAATTCTCCTTTCGTTT GAGAACCATGTGGATTCCCCAAAGCAGCAAGCCAAGATGGCGGAGTACTGCCGACTGATCTTTGGGGATGCCCTTCTCATGGAGCCCCTG GAAAAATATCCACTGGAATCTGGAGTTCCTCTTCCAAGCCCTATGGATTTAATGTATAAAATTTTGGTGAAAAATAAGAAGAAATCACAC AAGTCATCAGAAGGAAGCGGCAAAAAGAAGCTCTCAGAACAAGCCTCCAACACCTACAGTGACTCCTCCAGCATGTTCGAGCCCTCATCC CCAGGAGCCGGAGAAGCTGATACGGAAAGTGACGACGACGATGATGATGATGACTGTAAAAAATCTTCAATGGATGAGGTGTTAACTAAG GACCTTGAAAGGCATGCAGCTGAGTTACAAGCCCAGGAAGGATTGTCTAATGATGGAGAAACAATGGTAAATGTGCCACATATTCATGCA AGGGTGTACAACTATGAGCCTTTGACACAGCTCAAGAATGTCAGAGCAAATTACTATGGAAAATACATTGCTCTAAGAGGGACAGTGGTT CGTGTCAGTAATATAAAGCCTCTTTGCACCAAGATGGCTTTTCTTTGTGCTGCATGTGGAGAAATTCAGAGCTTTCCTCTTCCAGATGGA AAATACAGTCTTCCCACAAAGTGTCCTGTGCCTGTGTGTCGAGGCAGGTCATTTACTGCTCTCCGCAGCTCTCCTCTCACAGTTACGATG GACTGGCAGTCAATCAAAATCCAGGAATTGATGTCTGATGATCAGAGAGAAGCAGGTCGGATTCCACGAACAATAGAATGTGAGCTTGTT CATGATCTTGTGGATAGCTGTGTCCCGGGAGACACAGTGACTATTACTGGAATTGTCAAAGTCTCAAATGCGGAAGAAGGTTCTCGAAAT AAGAATGACAAGTGTATGTTCCTTTTGTATATTGAAGCAAATTCTATTAGTAATAGCAAAGGACAGAAAACAAAGAGTTCTGAGGATGGG TGTAAGCATGGAATGTTGATGGAGTTCTCACTTAAAGACCTTTATGCCATCCAAGAGATTCAAGCTGAAGAAAACCTGTTTAAACTCATT GTCAACTCGCTTTGCCCTGTCATTTTTGGTCATGAACTTGTTAAAGCAGGTTTGGCATTAGCACTCTTTGGAGGAAGCCAGAAATACGCA GATGACAAAAACAGAATTCCAATTCGGGGAGACCCCCACATCCTTGTTGTTGGAGATCCAGGCCTAGGAAAAAGTCAAATGCTACAGGCA GCGTGCAATGTTGCCCCACGTGGCGTGTATGTTTGTGGTAACACCACGACCACCTCTGGTCTGACGGTAACTCTTTCAAAAGATAGTTCC TCTGGAGATTTTGCTTTGGAAGCTGGTGCCCTGGTACTTGGTGATCAAGGTATTTGTGGAATCGATGAATTTGATAAGATGGGGAATCAA CATCAAGCCTTGTTGGAAGCCATGGAGCAGCAAAGTATTAGTCTTGCTAAGGCTGGTGTGGTTTGTAGCCTTCCTGCAAGAACTTCCATT ATTGCTGCTGCAAATCCAGTTGGAGGACATTACAATAAAGCCAAAACAGTTTCTGAGAATTTAAAAATGGGGAGTGCACTACTATCCAGA TTTGATTTGGTCTTTATCCTGTTAGATACTCCAAATGAGCATCATGATCACTTACTCTCTGAACATGTGATTGCAATAAGAGCTGGAAAG CAGAGAACCATTAGCAGTGCCACAGTAGCTCGTATGAATAGTCAAGATTCAAATACTTCCGTACTTGAAGTAGTTTCTGAGAAGCCATTA TCAGAAAGACTAAAGGTGGTTCCTGGAGAAACAATAGATCCCATTCCCCACCAGCTATTGAGAAAGTACATTGGCTATGCTCGGCAGTAT GTGTACCCAAGGCTATCCACAGAAGCTGCTCGAGTTCTTCAAGATTTTTACCTTGAGCTCCGGAAACAGAGCCAGAGGTTAAATAGCTCA CCAATCACTACCAGGCAGCTGGAATCTTTGATTCGTCTGACAGAGGCACGAGCAAGGTTGGAATTGAGAGAGGAAGCAACCAAAGAAGAC GCTGAGGATATAGTGGAAATTATGAAATATAGCATGCTAGGAACTTACTCTGATGAATTTGGGAACCTAGATTTTGAGCGATCCCAGCAT GGTTCTGGAATGAGCAACAGGTCAACAGCGAAAAGATTTATTTCTGCTCTCAACAACGTTGCTGAAAGAACTTATAATAATATATTTCAA TTTCATCAACTTCGGCAGATTGCCAAAGAACTAAACATTCAGGTTGCTGATTTTGAAAATTTTATTGGATCACTAAATGACCAGGGTTAC CTCTTGAAAAAAGGCCCAAAAGTTTACCAGCTTCAAACTATGTAAAAGGACTTCACCAAGTTAGGGCCTCCTGGGTTTATTGCAGATTAA AGCCATCTCAGTGAAGATATGCGTGCACGCACAGACAGACAGACACACACACACACACACACACACACACACACACACACACACACAGTC AAATACTGTTCTCTGAAAAATGATGTCCCAAAAGTATTATAATAGGAAAAAAGCATTAAATATAATAAACTAATTTAAGAAGTGATAAAG TCTCCAGATGCAGTAGCTCACACTGTAATCACAGTGACTCAGGAGGCTGAGGTGAGAGGATTCCTTGAGGCCAGGGTTCGAGACCAACCT TGGGCAACATAGCAAGACCCCATTTCTTAAAAAAAAAAAAAAAAAATTTAAACTTAGCTGGGTATGGTGGCACATGCCTATAGTCTCAGC TACTTGTGAGGCTGAGGCAGGAGGATTCTTTGAGCCCAGGAGTTTGAGGTTACAGTGAGCCACAATCACACCAATCACTGCACTCCAGCC TGGGCAATAAAGTAACTCTTGACTCAAAAAAATAAAAAAAATTGTAGTGGTAGCCATGTGTTAATTGTTAAATAAATTCTCCAAAGGGCT AAAAGTAAATTACTTATAAATTTTTTATAGTTGTATTTTTGACCTGCCTTTTATATGTATGAATATTTCATAGTTTTGCATATCAGATGT AGGCATACAGACAAATACATAAACCAATGAATATATTACATATTCTGTGTTCCAATAAAACTTTATTTATGGACACTAAAATTTGAATTT >65964_65964_4_PLCB1-MCM8_PLCB1_chr20_8703068_ENST00000338037_MCM8_chr20_5937772_ENST00000378896_length(amino acids)=1205AA_BP=527 MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKETELLDLSLVKDARCGRHAKAPKDPKLRELL DVGNIGRLEQRMITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSA DRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQ VQVLIEKYEPNNSLARKGQISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGV PLPSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSSSMFEPSSPGAGEADTESDDDDDDDDCKKSSMDEVLTKDLERHAAEL QAQEGLSNDGETMVNVPHIHARVYNYEPLTQLKNVRANYYGKYIALRGTVVRVSNIKPLCTKMAFLCAACGEIQSFPLPDGKYSLPTKCP VPVCRGRSFTALRSSPLTVTMDWQSIKIQELMSDDQREAGRIPRTIECELVHDLVDSCVPGDTVTITGIVKVSNAEEGSRNKNDKCMFLL YIEANSISNSKGQKTKSSEDGCKHGMLMEFSLKDLYAIQEIQAEENLFKLIVNSLCPVIFGHELVKAGLALALFGGSQKYADDKNRIPIR GDPHILVVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTTSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQALLEAME QQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEHHDHLLSEHVIAIRAGKQRTISSATV ARMNSQDSNTSVLEVVSEKPLSERLKVVPGETIDPIPHQLLRKYIGYARQYVYPRLSTEAARVLQDFYLELRKQSQRLNSSPITTRQLES LIRLTEARARLELREEATKEDAEDIVEIMKYSMLGTYSDEFGNLDFERSQHGSGMSNRSTAKRFISALNNVAERTYNNIFQFHQLRQIAK -------------------------------------------------------------- >65964_65964_5_PLCB1-MCM8_PLCB1_chr20_8703068_ENST00000378637_MCM8_chr20_5937772_ENST00000265187_length(transcript)=4388nt_BP=1584nt CAGATGGCCGGGGCTCAACCCGGAGTGCACGCCTTGCAACTCAAGCCCGTGTGCGTGTCCGACAGCCTCAAGAAGGGCACCAAATTCGTC AAGTGGGATGATGACTCAACTATTGTTACTCCAATTATTTTGAGGACTGACCCTCAGGGATTTTTCTTTTACTGGACAGATCAAAACAAG GAGACAGAGCTACTGGATCTCAGCCTTGTCAAAGATGCCAGATGTGGGAGACACGCCAAAGCTCCCAAGGACCCCAAATTACGTGAACTT TTGGATGTGGGGAACATCGGGCGCCTGGAGCAGCGCATGATCACAGTGGTGTATGGGCCTGACCTCGTGAACATCTCCCATTTGAATCTC GTGGCTTTCCAAGAAGAAGTGGCCAAGGAATGGACAAATGAGGTTTTCAGTTTGGCAACAAACCTGCTGGCCCAAAACATGTCCAGGGAT GCATTTCTGGAAAAAGCCTATACTAAACTTAAGCTGCAAGTCACTCCAGAAGGGCGTATTCCTCTCAAAAACATATATCGCTTGTTTTCA GCAGATCGGAAGCGAGTTGAAACTGCTTTAGAGGCTTGTAGTCTTCCATCTTCAAGGAATGATTCAATACCTCAAGAAGATTTCACTCCA GAAGTGTACAGAGTTTTCCTCAACAACCTTTGCCCTCGACCTGAAATTGATAACATCTTTTCAGAATTTGGTGCAAAAAGCAAACCATAT CTTACCGTTGATCAGATGATGGATTTTATCAACCTTAAGCAGCGAGATCCTCGGCTTAATGAAATACTTTATCCACCTCTAAAACAAGAG CAAGTCCAAGTATTGATTGAGAAGTATGAACCCAACAACAGCCTCGCCAGAAAAGGACAAATATCAGTGGATGGGTTCATGCGCTATCTG AGTGGAGAAGAAAACGGAGTCGTTTCACCTGAGAAACTGGATTTGAATGAAGACATGTCTCAGCCCCTTTCTCACTATTTCATTAATTCC TCGCACAACACCTACCTCACAGCTGGCCAACTGGCTGGAAACTCCTCTGTTGAGATGTATCGCCAAGTGCTCCTGTCTGGTTGTCGCTGT GTGGAGCTGGACTGCTGGAAGGGACGGACTGCAGAAGAGGAACCTGTCATCACCCATGGCTTCACCATGACAACTGAAATATCTTTCAAG GAAGTGATAGAAGCAATTGCGGAGTGTGCATTTAAGACTTCACCTTTTCCAATTCTCCTTTCGTTTGAGAACCATGTGGATTCCCCAAAG CAGCAAGCCAAGATGGCGGAGTACTGCCGACTGATCTTTGGGGATGCCCTTCTCATGGAGCCCCTGGAAAAATATCCACTGGAATCTGGA GTTCCTCTTCCAAGCCCTATGGATTTAATGTATAAAATTTTGGTGAAAAATAAGAAGAAATCACACAAGTCATCAGAAGGAAGCGGCAAA AAGAAGCTCTCAGAACAAGCCTCCAACACCTACAGTGACTCCTCCAGCATGTTCGAGCCCTCATCCCCAGGAGCCGGAGAAGCTGATACG GAAAGTGACGACGACGATGATGATGATGACTGTAAAAAATCTTCAATGGATGAGGTGTTAACTAAGGACCTTGAAAGGCATGCAGCTGAG TTACAAGCCCAGGAAGGATTGTCTAATGATGGAGAAACAATGGTAAATGTGCCACATATTCATGCAAGGGTGTACAACTATGAGCCTTTG ACACAGCTCAAGAATGTCAGAGCAAATTACTATGGAAAATACATTGCTCTAAGAGGGACAGTGGTTCGTGTCAGTAATATAAAGCCTCTT TGCACCAAGATGGCTTTTCTTTGTGCTGCATGTGGAGAAATTCAGAGCTTTCCTCTTCCAGATGGAAAATACAGTCTTCCCACAAAGTGT CCTGTGCCTGTGTGTCGAGGCAGGTCATTTACTGCTCTCCGCAGCTCTCCTCTCACAGTTACGATGGACTGGCAGTCAATCAAAATCCAG GAATTGATGTCTGATGATCAGAGAGAAGCAGGTCGGATTCCACGAACAATAGAATGTGAGCTTGTTCATGATCTTGTGGATAGCTGTGTC CCGGGAGACACAGTGACTATTACTGGAATTGTCAAAGTCTCAAATGCGGAAGAAGCAAATTCTATTAGTAATAGCAAAGGACAGAAAACA AAGAGTTCTGAGGATGGGTGTAAGCATGGAATGTTGATGGAGTTCTCACTTAAAGACCTTTATGCCATCCAAGAGATTCAAGCTGAAGAA AACCTGTTTAAACTCATTGTCAACTCGCTTTGCCCTGTCATTTTTGGTCATGAACTTGTTAAAGCAGGTTTGGCATTAGCACTCTTTGGA GGAAGCCAGAAATACGCAGATGACAAAAACAGAATTCCAATTCGGGGAGACCCCCACATCCTTGTTGTTGGAGATCCAGGCCTAGGAAAA AGTCAAATGCTACAGGCAGCGTGCAATGTTGCCCCACGTGGCGTGTATGTTTGTGGTAACACCACGACCACCTCTGGTCTGACGGTAACT CTTTCAAAAGATAGTTCCTCTGGAGATTTTGCTTTGGAAGCTGGTGCCCTGGTACTTGGTGATCAAGGTATTTGTGGAATCGATGAATTT GATAAGATGGGGAATCAACATCAAGCCTTGTTGGAAGCCATGGAGCAGCAAAGTATTAGTCTTGCTAAGGCTGGTGTGGTTTGTAGCCTT CCTGCAAGAACTTCCATTATTGCTGCTGCAAATCCAGTTGGAGGACATTACAATAAAGCCAAAACAGTTTCTGAGAATTTAAAAATGGGG AGTGCACTACTATCCAGATTTGATTTGGTCTTTATCCTGTTAGATACTCCAAATGAGCATCATGATCACTTACTCTCTGAACATGTGATT GCAATAAGAGCTGGAAAGCAGAGAACCATTAGCAGTGCCACAGTAGCTCGTATGAATAGTCAAGATTCAAATACTTCCGTACTTGAAGTA GTTTCTGAGAAGCCATTATCAGAAAGACTAAAGGTGGTTCCTGGAGAAACAATAGATCCCATTCCCCACCAGCTATTGAGAAAGTACATT GGCTATGCTCGGCAGTATGTGTACCCAAGGCTATCCACAGAAGCTGCTCGAGTTCTTCAAGATTTTTACCTTGAGCTCCGGAAACAGAGC CAGAGGTTAAATAGCTCACCAATCACTACCAGGCAGCTGGAATCTTTGATTCGTCTGACAGAGGCACGAGCAAGGTTGGAATTGAGAGAG GAAGCAACCAAAGAAGACGCTGAGGATATAGTGGAAATTATGAAATATAGCATGCTAGGAACTTACTCTGATGAATTTGGGAACCTAGAT TTTGAGCGATCCCAGCATGGTTCTGGAATGAGCAACAGGTCAACAGCGAAAAGATTTATTTCTGCTCTCAACAACGTTGCTGAAAGAACT TATAATAATATATTTCAATTTCATCAACTTCGGCAGATTGCCAAAGAACTAAACATTCAGGTTGCTGATTTTGAAAATTTTATTGGATCA CTAAATGACCAGGGTTACCTCTTGAAAAAAGGCCCAAAAGTTTACCAGCTTCAAACTATGTAAAAGGACTTCACCAAGTTAGGGCCTCCT GGGTTTATTGCAGATTAAAGCCATCTCAGTGAAGATATGCGTGCACGCACAGACAGACAGACACACACACACACACACACACACACACAC ACACACACACACACAGTCAAATACTGTTCTCTGAAAAATGATGTCCCAAAAGTATTATAATAGGAAAAAAGCATTAAATATAATAAACTA ATTTAAGAAGTGATAAAGTCTCCAGATGCAGTAGCTCACACTGTAATCACAGTGACTCAGGAGGCTGAGGTGAGAGGATTCCTTGAGGCC AGGGTTCGAGACCAACCTTGGGCAACATAGCAAGACCCCATTTCTTAAAAAAAAAAAAAAAAAATTTAAACTTAGCTGGGTATGGTGGCA CATGCCTATAGTCTCAGCTACTTGTGAGGCTGAGGCAGGAGGATTCTTTGAGCCCAGGAGTTTGAGGTTACAGTGAGCCACAATCACACC AATCACTGCACTCCAGCCTGGGCAATAAAGTAACTCTTGACTCAAAAAAATAAAAAAAATTGTAGTGGTAGCCATGTGTTAATTGTTAAA TAAATTCTCCAAAGGGCTAAAAGTAAATTACTTATAAATTTTTTATAGTTGTATTTTTGACCTGCCTTTTATATGTATGAATATTTCATA GTTTTGCATATCAGATGTAGGCATACAGACAAATACATAAACCAATGAATATATTACATATTCTGTGTTCCAATAAAACTTTATTTATGG >65964_65964_5_PLCB1-MCM8_PLCB1_chr20_8703068_ENST00000378637_MCM8_chr20_5937772_ENST00000265187_length(amino acids)=1189AA_BP=527 MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKETELLDLSLVKDARCGRHAKAPKDPKLRELL DVGNIGRLEQRMITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSA DRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQ VQVLIEKYEPNNSLARKGQISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGV PLPSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSSSMFEPSSPGAGEADTESDDDDDDDDCKKSSMDEVLTKDLERHAAEL QAQEGLSNDGETMVNVPHIHARVYNYEPLTQLKNVRANYYGKYIALRGTVVRVSNIKPLCTKMAFLCAACGEIQSFPLPDGKYSLPTKCP VPVCRGRSFTALRSSPLTVTMDWQSIKIQELMSDDQREAGRIPRTIECELVHDLVDSCVPGDTVTITGIVKVSNAEEANSISNSKGQKTK SSEDGCKHGMLMEFSLKDLYAIQEIQAEENLFKLIVNSLCPVIFGHELVKAGLALALFGGSQKYADDKNRIPIRGDPHILVVGDPGLGKS QMLQAACNVAPRGVYVCGNTTTTSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQALLEAMEQQSISLAKAGVVCSLP ARTSIIAAANPVGGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEHHDHLLSEHVIAIRAGKQRTISSATVARMNSQDSNTSVLEVV SEKPLSERLKVVPGETIDPIPHQLLRKYIGYARQYVYPRLSTEAARVLQDFYLELRKQSQRLNSSPITTRQLESLIRLTEARARLELREE ATKEDAEDIVEIMKYSMLGTYSDEFGNLDFERSQHGSGMSNRSTAKRFISALNNVAERTYNNIFQFHQLRQIAKELNIQVADFENFIGSL -------------------------------------------------------------- >65964_65964_6_PLCB1-MCM8_PLCB1_chr20_8703068_ENST00000378637_MCM8_chr20_5937772_ENST00000378883_length(transcript)=4270nt_BP=1584nt CAGATGGCCGGGGCTCAACCCGGAGTGCACGCCTTGCAACTCAAGCCCGTGTGCGTGTCCGACAGCCTCAAGAAGGGCACCAAATTCGTC AAGTGGGATGATGACTCAACTATTGTTACTCCAATTATTTTGAGGACTGACCCTCAGGGATTTTTCTTTTACTGGACAGATCAAAACAAG GAGACAGAGCTACTGGATCTCAGCCTTGTCAAAGATGCCAGATGTGGGAGACACGCCAAAGCTCCCAAGGACCCCAAATTACGTGAACTT TTGGATGTGGGGAACATCGGGCGCCTGGAGCAGCGCATGATCACAGTGGTGTATGGGCCTGACCTCGTGAACATCTCCCATTTGAATCTC GTGGCTTTCCAAGAAGAAGTGGCCAAGGAATGGACAAATGAGGTTTTCAGTTTGGCAACAAACCTGCTGGCCCAAAACATGTCCAGGGAT GCATTTCTGGAAAAAGCCTATACTAAACTTAAGCTGCAAGTCACTCCAGAAGGGCGTATTCCTCTCAAAAACATATATCGCTTGTTTTCA GCAGATCGGAAGCGAGTTGAAACTGCTTTAGAGGCTTGTAGTCTTCCATCTTCAAGGAATGATTCAATACCTCAAGAAGATTTCACTCCA GAAGTGTACAGAGTTTTCCTCAACAACCTTTGCCCTCGACCTGAAATTGATAACATCTTTTCAGAATTTGGTGCAAAAAGCAAACCATAT CTTACCGTTGATCAGATGATGGATTTTATCAACCTTAAGCAGCGAGATCCTCGGCTTAATGAAATACTTTATCCACCTCTAAAACAAGAG CAAGTCCAAGTATTGATTGAGAAGTATGAACCCAACAACAGCCTCGCCAGAAAAGGACAAATATCAGTGGATGGGTTCATGCGCTATCTG AGTGGAGAAGAAAACGGAGTCGTTTCACCTGAGAAACTGGATTTGAATGAAGACATGTCTCAGCCCCTTTCTCACTATTTCATTAATTCC TCGCACAACACCTACCTCACAGCTGGCCAACTGGCTGGAAACTCCTCTGTTGAGATGTATCGCCAAGTGCTCCTGTCTGGTTGTCGCTGT GTGGAGCTGGACTGCTGGAAGGGACGGACTGCAGAAGAGGAACCTGTCATCACCCATGGCTTCACCATGACAACTGAAATATCTTTCAAG GAAGTGATAGAAGCAATTGCGGAGTGTGCATTTAAGACTTCACCTTTTCCAATTCTCCTTTCGTTTGAGAACCATGTGGATTCCCCAAAG CAGCAAGCCAAGATGGCGGAGTACTGCCGACTGATCTTTGGGGATGCCCTTCTCATGGAGCCCCTGGAAAAATATCCACTGGAATCTGGA GTTCCTCTTCCAAGCCCTATGGATTTAATGTATAAAATTTTGGTGAAAAATAAGAAGAAATCACACAAGTCATCAGAAGGAAGCGGCAAA AAGAAGCTCTCAGAACAAGCCTCCAACACCTACAGTGACTCCTCCAGCATGTTCGAGCCCTCATCCCCAGGAGCCGGAGAAGCTGATACG GAAAGTGACGACGACGATGATGATGATGACTGTAAAAAATCTTCAATGGATGAGGTGTTAACTAAGGACCTTGAAAGGCATGCAGCTGAG TTACAAGCCCAGGAAGGATTGTCTAATGATGGAGAAACAATGGTAAATGTGCCACATATTCATGCAAGGGTGTACAACTATGAGCCTTTG ACACAGCTCAAGAATGTCAGAGCAAATTACTATGGAAAATACATTGCTCTAAGAGGGACAGTGGTTCGTGTCAGTAATATAAAGCCTCTT TGCACCAAGATGGCTTTTCTTTGTGCTGCATGTGGAGAAATTCAGAGCTTTCCTCTTCCAGATGGAAAATACAGTCTTCCCACAAAGTGT CCTGTGCCTGTGTGTCGAGGCAGGTCATTTACTGCTCTCCGCAGCTCTCCTCTCACAGTTACGATGGACTGGCAGTCAATCAAAATCCAG GAATTGATGTCTGATGATCAGAGAGAAGCAGGTCGGATTCCACGAACAATAGAATGTGAGCTTGTTCATGATCTTGTGGATAGCTGTGTC CCGGGAGACACAGTGACTATTACTGGAATTGTCAAAGTCTCAAATGCGGAAGAAGGTTCTCGAAATAAGAATGACAAGTGTATGTTCCTT TTGTATATTGAAGCAAATTCTATTAGTAATAGCAAAGGACAGAAAACAAAGAGTTCTGAGGATGGGTGTAAGCATGGAATGTTGATGGAG TTCTCACTTAAAGACCTTTATGCCATCCAAGAGATTCAAGCTGAAGAAAACCTGTTTAAACTCATTGTCAACTCGCTTTGCCCTGTCATT TTTGGTCATGAAGCAGCGTGCAATGTTGCCCCACGTGGCGTGTATGTTTGTGGTAACACCACGACCACCTCTGGTCTGACGGTAACTCTT TCAAAAGATAGTTCCTCTGGAGATTTTGCTTTGGAAGCTGGTGCCCTGGTACTTGGTGATCAAGGTATTTGTGGAATCGATGAATTTGAT AAGATGGGGAATCAACATCAAGCCTTGTTGGAAGCCATGGAGCAGCAAAGTATTAGTCTTGCTAAGGCTGGTGTGGTTTGTAGCCTTCCT GCAAGAACTTCCATTATTGCTGCTGCAAATCCAGTTGGAGGACATTACAATAAAGCCAAAACAGTTTCTGAGAATTTAAAAATGGGGAGT GCACTACTATCCAGATTTGATTTGGTCTTTATCCTGTTAGATACTCCAAATGAGCATCATGATCACTTACTCTCTGAACATGTGATTGCA ATAAGAGCTGGAAAGCAGAGAACCATTAGCAGTGCCACAGTAGCTCGTATGAATAGTCAAGATTCAAATACTTCCGTACTTGAAGTAGTT TCTGAGAAGCCATTATCAGAAAGACTAAAGGTGGTTCCTGGAGAAACAATAGATCCCATTCCCCACCAGCTATTGAGAAAGTACATTGGC TATGCTCGGCAGTATGTGTACCCAAGGCTATCCACAGAAGCTGCTCGAGTTCTTCAAGATTTTTACCTTGAGCTCCGGAAACAGAGCCAG AGGTTAAATAGCTCACCAATCACTACCAGGCAGCTGGAATCTTTGATTCGTCTGACAGAGGCACGAGCAAGGTTGGAATTGAGAGAGGAA GCAACCAAAGAAGACGCTGAGGATATAGTGGAAATTATGAAATATAGCATGCTAGGAACTTACTCTGATGAATTTGGGAACCTAGATTTT GAGCGATCCCAGCATGGTTCTGGAATGAGCAACAGGTCAACAGCGAAAAGATTTATTTCTGCTCTCAACAACGTTGCTGAAAGAACTTAT AATAATATATTTCAATTTCATCAACTTCGGCAGATTGCCAAAGAACTAAACATTCAGGTTGCTGATTTTGAAAATTTTATTGGATCACTA AATGACCAGGGTTACCTCTTGAAAAAAGGCCCAAAAGTTTACCAGCTTCAAACTATGTAAAAGGACTTCACCAAGTTAGGGCCTCCTGGG TTTATTGCAGATTAAAGCCATCTCAGTGAAGATATGCGTGCACGCACAGACAGACAGACACACACACACACACACACACACACACACACA CACACACACACAGTCAAATACTGTTCTCTGAAAAATGATGTCCCAAAAGTATTATAATAGGAAAAAAGCATTAAATATAATAAACTAATT TAAGAAGTGATAAAGTCTCCAGATGCAGTAGCTCACACTGTAATCACAGTGACTCAGGAGGCTGAGGTGAGAGGATTCCTTGAGGCCAGG GTTCGAGACCAACCTTGGGCAACATAGCAAGACCCCATTTCTTAAAAAAAAAAAAAAAAAATTTAAACTTAGCTGGGTATGGTGGCACAT GCCTATAGTCTCAGCTACTTGTGAGGCTGAGGCAGGAGGATTCTTTGAGCCCAGGAGTTTGAGGTTACAGTGAGCCACAATCACACCAAT CACTGCACTCCAGCCTGGGCAATAAAGTAACTCTTGACTCAAAAAAATAAAAAAAATTGTAGTGGTAGCCATGTGTTAATTGTTAAATAA ATTCTCCAAAGGGCTAAAAGTAAATTACTTATAAATTTTTTATAGTTGTATTTTTGACCTGCCTTTTATATGTATGAATATTTCATAGTT TTGCATATCAGATGTAGGCATACAGACAAATACATAAACCAATGAATATATTACATATTCTGTGTTCCAATAAAACTTTATTTATGGACA >65964_65964_6_PLCB1-MCM8_PLCB1_chr20_8703068_ENST00000378637_MCM8_chr20_5937772_ENST00000378883_length(amino acids)=1158AA_BP=527 MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKETELLDLSLVKDARCGRHAKAPKDPKLRELL DVGNIGRLEQRMITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSA DRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQ VQVLIEKYEPNNSLARKGQISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGV PLPSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSSSMFEPSSPGAGEADTESDDDDDDDDCKKSSMDEVLTKDLERHAAEL QAQEGLSNDGETMVNVPHIHARVYNYEPLTQLKNVRANYYGKYIALRGTVVRVSNIKPLCTKMAFLCAACGEIQSFPLPDGKYSLPTKCP VPVCRGRSFTALRSSPLTVTMDWQSIKIQELMSDDQREAGRIPRTIECELVHDLVDSCVPGDTVTITGIVKVSNAEEGSRNKNDKCMFLL YIEANSISNSKGQKTKSSEDGCKHGMLMEFSLKDLYAIQEIQAEENLFKLIVNSLCPVIFGHEAACNVAPRGVYVCGNTTTTSGLTVTLS KDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSA LLSRFDLVFILLDTPNEHHDHLLSEHVIAIRAGKQRTISSATVARMNSQDSNTSVLEVVSEKPLSERLKVVPGETIDPIPHQLLRKYIGY ARQYVYPRLSTEAARVLQDFYLELRKQSQRLNSSPITTRQLESLIRLTEARARLELREEATKEDAEDIVEIMKYSMLGTYSDEFGNLDFE -------------------------------------------------------------- >65964_65964_7_PLCB1-MCM8_PLCB1_chr20_8703068_ENST00000378637_MCM8_chr20_5937772_ENST00000378886_length(transcript)=3779nt_BP=1584nt CAGATGGCCGGGGCTCAACCCGGAGTGCACGCCTTGCAACTCAAGCCCGTGTGCGTGTCCGACAGCCTCAAGAAGGGCACCAAATTCGTC AAGTGGGATGATGACTCAACTATTGTTACTCCAATTATTTTGAGGACTGACCCTCAGGGATTTTTCTTTTACTGGACAGATCAAAACAAG GAGACAGAGCTACTGGATCTCAGCCTTGTCAAAGATGCCAGATGTGGGAGACACGCCAAAGCTCCCAAGGACCCCAAATTACGTGAACTT TTGGATGTGGGGAACATCGGGCGCCTGGAGCAGCGCATGATCACAGTGGTGTATGGGCCTGACCTCGTGAACATCTCCCATTTGAATCTC GTGGCTTTCCAAGAAGAAGTGGCCAAGGAATGGACAAATGAGGTTTTCAGTTTGGCAACAAACCTGCTGGCCCAAAACATGTCCAGGGAT GCATTTCTGGAAAAAGCCTATACTAAACTTAAGCTGCAAGTCACTCCAGAAGGGCGTATTCCTCTCAAAAACATATATCGCTTGTTTTCA GCAGATCGGAAGCGAGTTGAAACTGCTTTAGAGGCTTGTAGTCTTCCATCTTCAAGGAATGATTCAATACCTCAAGAAGATTTCACTCCA GAAGTGTACAGAGTTTTCCTCAACAACCTTTGCCCTCGACCTGAAATTGATAACATCTTTTCAGAATTTGGTGCAAAAAGCAAACCATAT CTTACCGTTGATCAGATGATGGATTTTATCAACCTTAAGCAGCGAGATCCTCGGCTTAATGAAATACTTTATCCACCTCTAAAACAAGAG CAAGTCCAAGTATTGATTGAGAAGTATGAACCCAACAACAGCCTCGCCAGAAAAGGACAAATATCAGTGGATGGGTTCATGCGCTATCTG AGTGGAGAAGAAAACGGAGTCGTTTCACCTGAGAAACTGGATTTGAATGAAGACATGTCTCAGCCCCTTTCTCACTATTTCATTAATTCC TCGCACAACACCTACCTCACAGCTGGCCAACTGGCTGGAAACTCCTCTGTTGAGATGTATCGCCAAGTGCTCCTGTCTGGTTGTCGCTGT GTGGAGCTGGACTGCTGGAAGGGACGGACTGCAGAAGAGGAACCTGTCATCACCCATGGCTTCACCATGACAACTGAAATATCTTTCAAG GAAGTGATAGAAGCAATTGCGGAGTGTGCATTTAAGACTTCACCTTTTCCAATTCTCCTTTCGTTTGAGAACCATGTGGATTCCCCAAAG CAGCAAGCCAAGATGGCGGAGTACTGCCGACTGATCTTTGGGGATGCCCTTCTCATGGAGCCCCTGGAAAAATATCCACTGGAATCTGGA GTTCCTCTTCCAAGCCCTATGGATTTAATGTATAAAATTTTGGTGAAAAATAAGAAGAAATCACACAAGTCATCAGAAGGAAGCGGCAAA AAGAAGCTCTCAGAACAAGCCTCCAACACCTACAGTGACTCCTCCAGCATGTTCGAGCCCTCATCCCCAGGAGCCGGAGAAGCTGATACG GAAAGTGACGACGACGATGATGATGATGACTGTAAAAAATCTTCAATGGATGAGGTGTTAACTAAGGACCTTGAAAGGCATGCAGCTGAG TTACAAGCCCAGGAAGGATTGTCTAATGATGGAGAAACAATGGTAAATGTGCCACATATTCATGCAAGGGTGTACAACTATGAGCCTTTG ACACAGCTCAAGAATGTCAGAGCAAATTACTATGGAAAATACATTGCTCTAAGAGGGACAGTGGTTCGTGTCAGTAATATAAAGCCTCTT TGCACCAAGATGGCTTTTCTTTGTGCTGCATGTGGAGAAATTCAGAGCTTTCCTCTTCCAGATGGAAAATACAGTCTTCCCACAAAGTGT CCTGTGCCTGTGTGTCGAGGCAGGTCATTTACTGCTCTCCGCAGCTCTCCTCTCACAGTTACGATGGACTGGCAGTCAATCAAAATCCAG GAATTGATGTCTGATGATCAGAGAGAAGCAGGTCGGATTCCACGAACAATAGAATGTGAGCTTGTTCATGATCTTGTGGATAGCTGTGTC CCGGGAGACACAGTGACTATTACTGGAATTGTCAAAGTCTCAAATGCGGAAGAAGGTTCTCGAAATAAGAATGACAAGTGTATGTTCCTT TTGTATATTGAAGCAAATTCTATTAGTAATAGCAAAGGACAGAAAACAAAGAGTTCTGAGGATGGGTGTAAGCATGGAATGTTGATGGAG TTCTCACTTAAAGACCTTTATGCCATCCAAGAGATTCAAGCTGAAGAAAACCTGTTTAAACTCATTGTCAAATGGAGTCTTGCTCTGTCG CCCAGGCTAGAGTACAGTGGTGCGATCTCAGCTCACTGCAACCTCCACCTCCCAAGTTCAAACAGTTCTCCCACCTCAGCCTGCCGAGTA GCTGGGACTACAGGCATGCGCCACCAGACCCAGCTACTTTTGCTTGTTAAAGCAGGTTTGGCATTAGCACTCTTTGGAGGAAGCCAGAAA TACGCAGATGACAAAAACAGAATTCCAATTCGGGGAGACCCCCACATCCTTGTTGTTGGAGATCCAGGCCTAGGAAAAAGTCAAATGCTA CAGGCAGCGTGCAATGTTGCCCCACGTGGCGTGTATGTTTGTGGTAACACCACGACCACCTCTGGTCTGACGGTAACTCTTTCAAAAGAT AGTTCCTCTGGAGATTTTGCTTTGGAAGCTGGTGCCCTGGTACTTGGTGATCAAGGTATTTGTGGAATCGATGAATTTGATAAGATGGGG AATCAACATCAAGCCTTGTTGGAAGCCATGGAGCAGCAAAGTATTAGTCTTGCTAAGGCTGGTGTGGTTTGTAGCCTTCCTGCAAGAACT TCCATTATTGCTGCTGCAAATCCAGTTGGAGGACATTACAATAAAGCCAAAACAGTTTCTGAGAATTTAAAAATGGGGAGTGCACTACTA TCCAGATTTGATTTGGTCTTTATCCTGTTAGATACTCCAAATGAGCATCATGATCACTTACTCTCTGAACATGTGATTGCAATAAGAGCT GGAAAGCAGAGAACCATTAGCAGTGCCACAGTAGCTCGTATGAATAGTCAAGATTCAAATACTTCCGTACTTGAAGTAGTTTCTGAGAAG CCATTATCAGAAAGACTAAAGGTGGTTCCTGGAGAAACAATAGATCCCATTCCCCACCAGCTATTGAGAAAGTACATTGGCTATGCTCGG CAGTATGTGTACCCAAGGCTATCCACAGAAGCTGCTCGAGTTCTTCAAGATTTTTACCTTGAGCTCCGGAAACAGAGCCAGAGGTTAAAT AGCTCACCAATCACTACCAGGCAGCTGGAATCTTTGATTCGTCTGACAGAGGCACGAGCAAGGTTGGAATTGAGAGAGGAAGCAACCAAA GAAGACGCTGAGGATATAGTGGAAATTATGAAATATAGCATGCTAGGAACTTACTCTGATGAATTTGGGAACCTAGATTTTGAGCGATCC CAGCATGGTTCTGGAATGAGCAACAGGTCAACAGCGAAAAGATTTATTTCTGCTCTCAACAACGTTGCTGAAAGAACTTATAATAATATA TTTCAATTTCATCAACTTCGGCAGATTGCCAAAGAACTAAACATTCAGGTTGCTGATTTTGAAAATTTTATTGGATCACTAAATGACCAG >65964_65964_7_PLCB1-MCM8_PLCB1_chr20_8703068_ENST00000378637_MCM8_chr20_5937772_ENST00000378886_length(amino acids)=1245AA_BP=774 MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKETELLDLSLVKDARCGRHAKAPKDPKLRELL DVGNIGRLEQRMITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSA DRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQ VQVLIEKYEPNNSLARKGQISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGV PLPSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSSSMFEPSSPGAGEADTESDDDDDDDDCKKSSMDEVLTKDLERHAAEL QAQEGLSNDGETMVNVPHIHARVYNYEPLTQLKNVRANYYGKYIALRGTVVRVSNIKPLCTKMAFLCAACGEIQSFPLPDGKYSLPTKCP VPVCRGRSFTALRSSPLTVTMDWQSIKIQELMSDDQREAGRIPRTIECELVHDLVDSCVPGDTVTITGIVKVSNAEEGSRNKNDKCMFLL YIEANSISNSKGQKTKSSEDGCKHGMLMEFSLKDLYAIQEIQAEENLFKLIVKWSLALSPRLEYSGAISAHCNLHLPSSNSSPTSACRVA GTTGMRHQTQLLLLVKAGLALALFGGSQKYADDKNRIPIRGDPHILVVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTTSGLTVTLSKDS SSGDFALEAGALVLGDQGICGIDEFDKMGNQHQALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALLS RFDLVFILLDTPNEHHDHLLSEHVIAIRAGKQRTISSATVARMNSQDSNTSVLEVVSEKPLSERLKVVPGETIDPIPHQLLRKYIGYARQ YVYPRLSTEAARVLQDFYLELRKQSQRLNSSPITTRQLESLIRLTEARARLELREEATKEDAEDIVEIMKYSMLGTYSDEFGNLDFERSQ -------------------------------------------------------------- >65964_65964_8_PLCB1-MCM8_PLCB1_chr20_8703068_ENST00000378637_MCM8_chr20_5937772_ENST00000378896_length(transcript)=4436nt_BP=1584nt CAGATGGCCGGGGCTCAACCCGGAGTGCACGCCTTGCAACTCAAGCCCGTGTGCGTGTCCGACAGCCTCAAGAAGGGCACCAAATTCGTC AAGTGGGATGATGACTCAACTATTGTTACTCCAATTATTTTGAGGACTGACCCTCAGGGATTTTTCTTTTACTGGACAGATCAAAACAAG GAGACAGAGCTACTGGATCTCAGCCTTGTCAAAGATGCCAGATGTGGGAGACACGCCAAAGCTCCCAAGGACCCCAAATTACGTGAACTT TTGGATGTGGGGAACATCGGGCGCCTGGAGCAGCGCATGATCACAGTGGTGTATGGGCCTGACCTCGTGAACATCTCCCATTTGAATCTC GTGGCTTTCCAAGAAGAAGTGGCCAAGGAATGGACAAATGAGGTTTTCAGTTTGGCAACAAACCTGCTGGCCCAAAACATGTCCAGGGAT GCATTTCTGGAAAAAGCCTATACTAAACTTAAGCTGCAAGTCACTCCAGAAGGGCGTATTCCTCTCAAAAACATATATCGCTTGTTTTCA GCAGATCGGAAGCGAGTTGAAACTGCTTTAGAGGCTTGTAGTCTTCCATCTTCAAGGAATGATTCAATACCTCAAGAAGATTTCACTCCA GAAGTGTACAGAGTTTTCCTCAACAACCTTTGCCCTCGACCTGAAATTGATAACATCTTTTCAGAATTTGGTGCAAAAAGCAAACCATAT CTTACCGTTGATCAGATGATGGATTTTATCAACCTTAAGCAGCGAGATCCTCGGCTTAATGAAATACTTTATCCACCTCTAAAACAAGAG CAAGTCCAAGTATTGATTGAGAAGTATGAACCCAACAACAGCCTCGCCAGAAAAGGACAAATATCAGTGGATGGGTTCATGCGCTATCTG AGTGGAGAAGAAAACGGAGTCGTTTCACCTGAGAAACTGGATTTGAATGAAGACATGTCTCAGCCCCTTTCTCACTATTTCATTAATTCC TCGCACAACACCTACCTCACAGCTGGCCAACTGGCTGGAAACTCCTCTGTTGAGATGTATCGCCAAGTGCTCCTGTCTGGTTGTCGCTGT GTGGAGCTGGACTGCTGGAAGGGACGGACTGCAGAAGAGGAACCTGTCATCACCCATGGCTTCACCATGACAACTGAAATATCTTTCAAG GAAGTGATAGAAGCAATTGCGGAGTGTGCATTTAAGACTTCACCTTTTCCAATTCTCCTTTCGTTTGAGAACCATGTGGATTCCCCAAAG CAGCAAGCCAAGATGGCGGAGTACTGCCGACTGATCTTTGGGGATGCCCTTCTCATGGAGCCCCTGGAAAAATATCCACTGGAATCTGGA GTTCCTCTTCCAAGCCCTATGGATTTAATGTATAAAATTTTGGTGAAAAATAAGAAGAAATCACACAAGTCATCAGAAGGAAGCGGCAAA AAGAAGCTCTCAGAACAAGCCTCCAACACCTACAGTGACTCCTCCAGCATGTTCGAGCCCTCATCCCCAGGAGCCGGAGAAGCTGATACG GAAAGTGACGACGACGATGATGATGATGACTGTAAAAAATCTTCAATGGATGAGGTGTTAACTAAGGACCTTGAAAGGCATGCAGCTGAG TTACAAGCCCAGGAAGGATTGTCTAATGATGGAGAAACAATGGTAAATGTGCCACATATTCATGCAAGGGTGTACAACTATGAGCCTTTG ACACAGCTCAAGAATGTCAGAGCAAATTACTATGGAAAATACATTGCTCTAAGAGGGACAGTGGTTCGTGTCAGTAATATAAAGCCTCTT TGCACCAAGATGGCTTTTCTTTGTGCTGCATGTGGAGAAATTCAGAGCTTTCCTCTTCCAGATGGAAAATACAGTCTTCCCACAAAGTGT CCTGTGCCTGTGTGTCGAGGCAGGTCATTTACTGCTCTCCGCAGCTCTCCTCTCACAGTTACGATGGACTGGCAGTCAATCAAAATCCAG GAATTGATGTCTGATGATCAGAGAGAAGCAGGTCGGATTCCACGAACAATAGAATGTGAGCTTGTTCATGATCTTGTGGATAGCTGTGTC CCGGGAGACACAGTGACTATTACTGGAATTGTCAAAGTCTCAAATGCGGAAGAAGGTTCTCGAAATAAGAATGACAAGTGTATGTTCCTT TTGTATATTGAAGCAAATTCTATTAGTAATAGCAAAGGACAGAAAACAAAGAGTTCTGAGGATGGGTGTAAGCATGGAATGTTGATGGAG TTCTCACTTAAAGACCTTTATGCCATCCAAGAGATTCAAGCTGAAGAAAACCTGTTTAAACTCATTGTCAACTCGCTTTGCCCTGTCATT TTTGGTCATGAACTTGTTAAAGCAGGTTTGGCATTAGCACTCTTTGGAGGAAGCCAGAAATACGCAGATGACAAAAACAGAATTCCAATT CGGGGAGACCCCCACATCCTTGTTGTTGGAGATCCAGGCCTAGGAAAAAGTCAAATGCTACAGGCAGCGTGCAATGTTGCCCCACGTGGC GTGTATGTTTGTGGTAACACCACGACCACCTCTGGTCTGACGGTAACTCTTTCAAAAGATAGTTCCTCTGGAGATTTTGCTTTGGAAGCT GGTGCCCTGGTACTTGGTGATCAAGGTATTTGTGGAATCGATGAATTTGATAAGATGGGGAATCAACATCAAGCCTTGTTGGAAGCCATG GAGCAGCAAAGTATTAGTCTTGCTAAGGCTGGTGTGGTTTGTAGCCTTCCTGCAAGAACTTCCATTATTGCTGCTGCAAATCCAGTTGGA GGACATTACAATAAAGCCAAAACAGTTTCTGAGAATTTAAAAATGGGGAGTGCACTACTATCCAGATTTGATTTGGTCTTTATCCTGTTA GATACTCCAAATGAGCATCATGATCACTTACTCTCTGAACATGTGATTGCAATAAGAGCTGGAAAGCAGAGAACCATTAGCAGTGCCACA GTAGCTCGTATGAATAGTCAAGATTCAAATACTTCCGTACTTGAAGTAGTTTCTGAGAAGCCATTATCAGAAAGACTAAAGGTGGTTCCT GGAGAAACAATAGATCCCATTCCCCACCAGCTATTGAGAAAGTACATTGGCTATGCTCGGCAGTATGTGTACCCAAGGCTATCCACAGAA GCTGCTCGAGTTCTTCAAGATTTTTACCTTGAGCTCCGGAAACAGAGCCAGAGGTTAAATAGCTCACCAATCACTACCAGGCAGCTGGAA TCTTTGATTCGTCTGACAGAGGCACGAGCAAGGTTGGAATTGAGAGAGGAAGCAACCAAAGAAGACGCTGAGGATATAGTGGAAATTATG AAATATAGCATGCTAGGAACTTACTCTGATGAATTTGGGAACCTAGATTTTGAGCGATCCCAGCATGGTTCTGGAATGAGCAACAGGTCA ACAGCGAAAAGATTTATTTCTGCTCTCAACAACGTTGCTGAAAGAACTTATAATAATATATTTCAATTTCATCAACTTCGGCAGATTGCC AAAGAACTAAACATTCAGGTTGCTGATTTTGAAAATTTTATTGGATCACTAAATGACCAGGGTTACCTCTTGAAAAAAGGCCCAAAAGTT TACCAGCTTCAAACTATGTAAAAGGACTTCACCAAGTTAGGGCCTCCTGGGTTTATTGCAGATTAAAGCCATCTCAGTGAAGATATGCGT GCACGCACAGACAGACAGACACACACACACACACACACACACACACACACACACACACACACAGTCAAATACTGTTCTCTGAAAAATGAT GTCCCAAAAGTATTATAATAGGAAAAAAGCATTAAATATAATAAACTAATTTAAGAAGTGATAAAGTCTCCAGATGCAGTAGCTCACACT GTAATCACAGTGACTCAGGAGGCTGAGGTGAGAGGATTCCTTGAGGCCAGGGTTCGAGACCAACCTTGGGCAACATAGCAAGACCCCATT TCTTAAAAAAAAAAAAAAAAAATTTAAACTTAGCTGGGTATGGTGGCACATGCCTATAGTCTCAGCTACTTGTGAGGCTGAGGCAGGAGG ATTCTTTGAGCCCAGGAGTTTGAGGTTACAGTGAGCCACAATCACACCAATCACTGCACTCCAGCCTGGGCAATAAAGTAACTCTTGACT CAAAAAAATAAAAAAAATTGTAGTGGTAGCCATGTGTTAATTGTTAAATAAATTCTCCAAAGGGCTAAAAGTAAATTACTTATAAATTTT TTATAGTTGTATTTTTGACCTGCCTTTTATATGTATGAATATTTCATAGTTTTGCATATCAGATGTAGGCATACAGACAAATACATAAAC CAATGAATATATTACATATTCTGTGTTCCAATAAAACTTTATTTATGGACACTAAAATTTGAATTTCATAAAATTTTCCCATGTCAAGAA >65964_65964_8_PLCB1-MCM8_PLCB1_chr20_8703068_ENST00000378637_MCM8_chr20_5937772_ENST00000378896_length(amino acids)=1205AA_BP=527 MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKETELLDLSLVKDARCGRHAKAPKDPKLRELL DVGNIGRLEQRMITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSA DRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQ VQVLIEKYEPNNSLARKGQISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGV PLPSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSSSMFEPSSPGAGEADTESDDDDDDDDCKKSSMDEVLTKDLERHAAEL QAQEGLSNDGETMVNVPHIHARVYNYEPLTQLKNVRANYYGKYIALRGTVVRVSNIKPLCTKMAFLCAACGEIQSFPLPDGKYSLPTKCP VPVCRGRSFTALRSSPLTVTMDWQSIKIQELMSDDQREAGRIPRTIECELVHDLVDSCVPGDTVTITGIVKVSNAEEGSRNKNDKCMFLL YIEANSISNSKGQKTKSSEDGCKHGMLMEFSLKDLYAIQEIQAEENLFKLIVNSLCPVIFGHELVKAGLALALFGGSQKYADDKNRIPIR GDPHILVVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTTSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQALLEAME QQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEHHDHLLSEHVIAIRAGKQRTISSATV ARMNSQDSNTSVLEVVSEKPLSERLKVVPGETIDPIPHQLLRKYIGYARQYVYPRLSTEAARVLQDFYLELRKQSQRLNSSPITTRQLES LIRLTEARARLELREEATKEDAEDIVEIMKYSMLGTYSDEFGNLDFERSQHGSGMSNRSTAKRFISALNNVAERTYNNIFQFHQLRQIAK -------------------------------------------------------------- >65964_65964_9_PLCB1-MCM8_PLCB1_chr20_8703068_ENST00000378641_MCM8_chr20_5937772_ENST00000265187_length(transcript)=4860nt_BP=2056nt CAGCGAGCGAGGGTGGCGGGGAAGGGGGGCGGGGGGGAGGAGGAGGGAGGAGGGAAAAGAGCGGTTAGGGGGGGCGCCGGGCGTGTGTCA CTCGCTCTCTCCCTCTGTGTATAGAGGATGTGCTGAATGGTGCGCTTTGAGGCGGCGGCGGCGGAGGAGCAGAATCCGCCGCGACTGGCA GCCTCGGCTGACCGGCTCGGCTTCTCTTCGCCTTCCGAGGCTCCTCATCCACCGCGGGCTCCAGACCTCGCGTCCCGCCCGGGGCATGGC CGGGCGCTGCGCCCCCGCGCGCTCTGCCTGCTGAGCGGCGCCGGAGGGAGGTGCGGAGGCCGGGAGGCCGGGGAGGCCGGCGGGGAGCAG AGTCGAGCGCCTCCGGAGCAGAGAAAGGAGCCCGCGCCCCGCGCCCCGCGCCCCGCGCACGGTCCCCAGTCCCTGCCGCGCTCGCCCGGG CCGCCCGGAGCCCAGATGAGCCCAGATGGCCGGGGCTCAACCCGGAGTGCACGCCTTGCAACTCAAGCCCGTGTGCGTGTCCGACAGCCT CAAGAAGGGCACCAAATTCGTCAAGTGGGATGATGACTCAACTATTGTTACTCCAATTATTTTGAGGACTGACCCTCAGGGATTTTTCTT TTACTGGACAGATCAAAACAAGGAGACAGAGCTACTGGATCTCAGCCTTGTCAAAGATGCCAGATGTGGGAGACACGCCAAAGCTCCCAA GGACCCCAAATTACGTGAACTTTTGGATGTGGGGAACATCGGGCGCCTGGAGCAGCGCATGATCACAGTGGTGTATGGGCCTGACCTCGT GAACATCTCCCATTTGAATCTCGTGGCTTTCCAAGAAGAAGTGGCCAAGGAATGGACAAATGAGGTTTTCAGTTTGGCAACAAACCTGCT GGCCCAAAACATGTCCAGGGATGCATTTCTGGAAAAAGCCTATACTAAACTTAAGCTGCAAGTCACTCCAGAAGGGCGTATTCCTCTCAA AAACATATATCGCTTGTTTTCAGCAGATCGGAAGCGAGTTGAAACTGCTTTAGAGGCTTGTAGTCTTCCATCTTCAAGGAATGATTCAAT ACCTCAAGAAGATTTCACTCCAGAAGTGTACAGAGTTTTCCTCAACAACCTTTGCCCTCGACCTGAAATTGATAACATCTTTTCAGAATT TGGTGCAAAAAGCAAACCATATCTTACCGTTGATCAGATGATGGATTTTATCAACCTTAAGCAGCGAGATCCTCGGCTTAATGAAATACT TTATCCACCTCTAAAACAAGAGCAAGTCCAAGTATTGATTGAGAAGTATGAACCCAACAACAGCCTCGCCAGAAAAGGACAAATATCAGT GGATGGGTTCATGCGCTATCTGAGTGGAGAAGAAAACGGAGTCGTTTCACCTGAGAAACTGGATTTGAATGAAGACATGTCTCAGCCCCT TTCTCACTATTTCATTAATTCCTCGCACAACACCTACCTCACAGCTGGCCAACTGGCTGGAAACTCCTCTGTTGAGATGTATCGCCAAGT GCTCCTGTCTGGTTGTCGCTGTGTGGAGCTGGACTGCTGGAAGGGACGGACTGCAGAAGAGGAACCTGTCATCACCCATGGCTTCACCAT GACAACTGAAATATCTTTCAAGGAAGTGATAGAAGCAATTGCGGAGTGTGCATTTAAGACTTCACCTTTTCCAATTCTCCTTTCGTTTGA GAACCATGTGGATTCCCCAAAGCAGCAAGCCAAGATGGCGGAGTACTGCCGACTGATCTTTGGGGATGCCCTTCTCATGGAGCCCCTGGA AAAATATCCACTGGAATCTGGAGTTCCTCTTCCAAGCCCTATGGATTTAATGTATAAAATTTTGGTGAAAAATAAGAAGAAATCACACAA GTCATCAGAAGGAAGCGGCAAAAAGAAGCTCTCAGAACAAGCCTCCAACACCTACAGTGACTCCTCCAGCATGTTCGAGCCCTCATCCCC AGGAGCCGGAGAAGCTGATACGGAAAGTGACGACGACGATGATGATGATGACTGTAAAAAATCTTCAATGGATGAGGTGTTAACTAAGGA CCTTGAAAGGCATGCAGCTGAGTTACAAGCCCAGGAAGGATTGTCTAATGATGGAGAAACAATGGTAAATGTGCCACATATTCATGCAAG GGTGTACAACTATGAGCCTTTGACACAGCTCAAGAATGTCAGAGCAAATTACTATGGAAAATACATTGCTCTAAGAGGGACAGTGGTTCG TGTCAGTAATATAAAGCCTCTTTGCACCAAGATGGCTTTTCTTTGTGCTGCATGTGGAGAAATTCAGAGCTTTCCTCTTCCAGATGGAAA ATACAGTCTTCCCACAAAGTGTCCTGTGCCTGTGTGTCGAGGCAGGTCATTTACTGCTCTCCGCAGCTCTCCTCTCACAGTTACGATGGA CTGGCAGTCAATCAAAATCCAGGAATTGATGTCTGATGATCAGAGAGAAGCAGGTCGGATTCCACGAACAATAGAATGTGAGCTTGTTCA TGATCTTGTGGATAGCTGTGTCCCGGGAGACACAGTGACTATTACTGGAATTGTCAAAGTCTCAAATGCGGAAGAAGCAAATTCTATTAG TAATAGCAAAGGACAGAAAACAAAGAGTTCTGAGGATGGGTGTAAGCATGGAATGTTGATGGAGTTCTCACTTAAAGACCTTTATGCCAT CCAAGAGATTCAAGCTGAAGAAAACCTGTTTAAACTCATTGTCAACTCGCTTTGCCCTGTCATTTTTGGTCATGAACTTGTTAAAGCAGG TTTGGCATTAGCACTCTTTGGAGGAAGCCAGAAATACGCAGATGACAAAAACAGAATTCCAATTCGGGGAGACCCCCACATCCTTGTTGT TGGAGATCCAGGCCTAGGAAAAAGTCAAATGCTACAGGCAGCGTGCAATGTTGCCCCACGTGGCGTGTATGTTTGTGGTAACACCACGAC CACCTCTGGTCTGACGGTAACTCTTTCAAAAGATAGTTCCTCTGGAGATTTTGCTTTGGAAGCTGGTGCCCTGGTACTTGGTGATCAAGG TATTTGTGGAATCGATGAATTTGATAAGATGGGGAATCAACATCAAGCCTTGTTGGAAGCCATGGAGCAGCAAAGTATTAGTCTTGCTAA GGCTGGTGTGGTTTGTAGCCTTCCTGCAAGAACTTCCATTATTGCTGCTGCAAATCCAGTTGGAGGACATTACAATAAAGCCAAAACAGT TTCTGAGAATTTAAAAATGGGGAGTGCACTACTATCCAGATTTGATTTGGTCTTTATCCTGTTAGATACTCCAAATGAGCATCATGATCA CTTACTCTCTGAACATGTGATTGCAATAAGAGCTGGAAAGCAGAGAACCATTAGCAGTGCCACAGTAGCTCGTATGAATAGTCAAGATTC AAATACTTCCGTACTTGAAGTAGTTTCTGAGAAGCCATTATCAGAAAGACTAAAGGTGGTTCCTGGAGAAACAATAGATCCCATTCCCCA CCAGCTATTGAGAAAGTACATTGGCTATGCTCGGCAGTATGTGTACCCAAGGCTATCCACAGAAGCTGCTCGAGTTCTTCAAGATTTTTA CCTTGAGCTCCGGAAACAGAGCCAGAGGTTAAATAGCTCACCAATCACTACCAGGCAGCTGGAATCTTTGATTCGTCTGACAGAGGCACG AGCAAGGTTGGAATTGAGAGAGGAAGCAACCAAAGAAGACGCTGAGGATATAGTGGAAATTATGAAATATAGCATGCTAGGAACTTACTC TGATGAATTTGGGAACCTAGATTTTGAGCGATCCCAGCATGGTTCTGGAATGAGCAACAGGTCAACAGCGAAAAGATTTATTTCTGCTCT CAACAACGTTGCTGAAAGAACTTATAATAATATATTTCAATTTCATCAACTTCGGCAGATTGCCAAAGAACTAAACATTCAGGTTGCTGA TTTTGAAAATTTTATTGGATCACTAAATGACCAGGGTTACCTCTTGAAAAAAGGCCCAAAAGTTTACCAGCTTCAAACTATGTAAAAGGA CTTCACCAAGTTAGGGCCTCCTGGGTTTATTGCAGATTAAAGCCATCTCAGTGAAGATATGCGTGCACGCACAGACAGACAGACACACAC ACACACACACACACACACACACACACACACACACACAGTCAAATACTGTTCTCTGAAAAATGATGTCCCAAAAGTATTATAATAGGAAAA AAGCATTAAATATAATAAACTAATTTAAGAAGTGATAAAGTCTCCAGATGCAGTAGCTCACACTGTAATCACAGTGACTCAGGAGGCTGA GGTGAGAGGATTCCTTGAGGCCAGGGTTCGAGACCAACCTTGGGCAACATAGCAAGACCCCATTTCTTAAAAAAAAAAAAAAAAAATTTA AACTTAGCTGGGTATGGTGGCACATGCCTATAGTCTCAGCTACTTGTGAGGCTGAGGCAGGAGGATTCTTTGAGCCCAGGAGTTTGAGGT TACAGTGAGCCACAATCACACCAATCACTGCACTCCAGCCTGGGCAATAAAGTAACTCTTGACTCAAAAAAATAAAAAAAATTGTAGTGG TAGCCATGTGTTAATTGTTAAATAAATTCTCCAAAGGGCTAAAAGTAAATTACTTATAAATTTTTTATAGTTGTATTTTTGACCTGCCTT TTATATGTATGAATATTTCATAGTTTTGCATATCAGATGTAGGCATACAGACAAATACATAAACCAATGAATATATTACATATTCTGTGT TCCAATAAAACTTTATTTATGGACACTAAAATTTGAATTTCATAAAATTTTCCCATGTCAAGAATACAAAATACTTGAGTTTTGTTTTTA >65964_65964_9_PLCB1-MCM8_PLCB1_chr20_8703068_ENST00000378641_MCM8_chr20_5937772_ENST00000265187_length(amino acids)=1189AA_BP=527 MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKETELLDLSLVKDARCGRHAKAPKDPKLRELL DVGNIGRLEQRMITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSA DRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQ VQVLIEKYEPNNSLARKGQISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGV PLPSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSSSMFEPSSPGAGEADTESDDDDDDDDCKKSSMDEVLTKDLERHAAEL QAQEGLSNDGETMVNVPHIHARVYNYEPLTQLKNVRANYYGKYIALRGTVVRVSNIKPLCTKMAFLCAACGEIQSFPLPDGKYSLPTKCP VPVCRGRSFTALRSSPLTVTMDWQSIKIQELMSDDQREAGRIPRTIECELVHDLVDSCVPGDTVTITGIVKVSNAEEANSISNSKGQKTK SSEDGCKHGMLMEFSLKDLYAIQEIQAEENLFKLIVNSLCPVIFGHELVKAGLALALFGGSQKYADDKNRIPIRGDPHILVVGDPGLGKS QMLQAACNVAPRGVYVCGNTTTTSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQALLEAMEQQSISLAKAGVVCSLP ARTSIIAAANPVGGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEHHDHLLSEHVIAIRAGKQRTISSATVARMNSQDSNTSVLEVV SEKPLSERLKVVPGETIDPIPHQLLRKYIGYARQYVYPRLSTEAARVLQDFYLELRKQSQRLNSSPITTRQLESLIRLTEARARLELREE ATKEDAEDIVEIMKYSMLGTYSDEFGNLDFERSQHGSGMSNRSTAKRFISALNNVAERTYNNIFQFHQLRQIAKELNIQVADFENFIGSL -------------------------------------------------------------- >65964_65964_10_PLCB1-MCM8_PLCB1_chr20_8703068_ENST00000378641_MCM8_chr20_5937772_ENST00000378883_length(transcript)=4742nt_BP=2056nt CAGCGAGCGAGGGTGGCGGGGAAGGGGGGCGGGGGGGAGGAGGAGGGAGGAGGGAAAAGAGCGGTTAGGGGGGGCGCCGGGCGTGTGTCA CTCGCTCTCTCCCTCTGTGTATAGAGGATGTGCTGAATGGTGCGCTTTGAGGCGGCGGCGGCGGAGGAGCAGAATCCGCCGCGACTGGCA GCCTCGGCTGACCGGCTCGGCTTCTCTTCGCCTTCCGAGGCTCCTCATCCACCGCGGGCTCCAGACCTCGCGTCCCGCCCGGGGCATGGC CGGGCGCTGCGCCCCCGCGCGCTCTGCCTGCTGAGCGGCGCCGGAGGGAGGTGCGGAGGCCGGGAGGCCGGGGAGGCCGGCGGGGAGCAG AGTCGAGCGCCTCCGGAGCAGAGAAAGGAGCCCGCGCCCCGCGCCCCGCGCCCCGCGCACGGTCCCCAGTCCCTGCCGCGCTCGCCCGGG CCGCCCGGAGCCCAGATGAGCCCAGATGGCCGGGGCTCAACCCGGAGTGCACGCCTTGCAACTCAAGCCCGTGTGCGTGTCCGACAGCCT CAAGAAGGGCACCAAATTCGTCAAGTGGGATGATGACTCAACTATTGTTACTCCAATTATTTTGAGGACTGACCCTCAGGGATTTTTCTT TTACTGGACAGATCAAAACAAGGAGACAGAGCTACTGGATCTCAGCCTTGTCAAAGATGCCAGATGTGGGAGACACGCCAAAGCTCCCAA GGACCCCAAATTACGTGAACTTTTGGATGTGGGGAACATCGGGCGCCTGGAGCAGCGCATGATCACAGTGGTGTATGGGCCTGACCTCGT GAACATCTCCCATTTGAATCTCGTGGCTTTCCAAGAAGAAGTGGCCAAGGAATGGACAAATGAGGTTTTCAGTTTGGCAACAAACCTGCT GGCCCAAAACATGTCCAGGGATGCATTTCTGGAAAAAGCCTATACTAAACTTAAGCTGCAAGTCACTCCAGAAGGGCGTATTCCTCTCAA AAACATATATCGCTTGTTTTCAGCAGATCGGAAGCGAGTTGAAACTGCTTTAGAGGCTTGTAGTCTTCCATCTTCAAGGAATGATTCAAT ACCTCAAGAAGATTTCACTCCAGAAGTGTACAGAGTTTTCCTCAACAACCTTTGCCCTCGACCTGAAATTGATAACATCTTTTCAGAATT TGGTGCAAAAAGCAAACCATATCTTACCGTTGATCAGATGATGGATTTTATCAACCTTAAGCAGCGAGATCCTCGGCTTAATGAAATACT TTATCCACCTCTAAAACAAGAGCAAGTCCAAGTATTGATTGAGAAGTATGAACCCAACAACAGCCTCGCCAGAAAAGGACAAATATCAGT GGATGGGTTCATGCGCTATCTGAGTGGAGAAGAAAACGGAGTCGTTTCACCTGAGAAACTGGATTTGAATGAAGACATGTCTCAGCCCCT TTCTCACTATTTCATTAATTCCTCGCACAACACCTACCTCACAGCTGGCCAACTGGCTGGAAACTCCTCTGTTGAGATGTATCGCCAAGT GCTCCTGTCTGGTTGTCGCTGTGTGGAGCTGGACTGCTGGAAGGGACGGACTGCAGAAGAGGAACCTGTCATCACCCATGGCTTCACCAT GACAACTGAAATATCTTTCAAGGAAGTGATAGAAGCAATTGCGGAGTGTGCATTTAAGACTTCACCTTTTCCAATTCTCCTTTCGTTTGA GAACCATGTGGATTCCCCAAAGCAGCAAGCCAAGATGGCGGAGTACTGCCGACTGATCTTTGGGGATGCCCTTCTCATGGAGCCCCTGGA AAAATATCCACTGGAATCTGGAGTTCCTCTTCCAAGCCCTATGGATTTAATGTATAAAATTTTGGTGAAAAATAAGAAGAAATCACACAA GTCATCAGAAGGAAGCGGCAAAAAGAAGCTCTCAGAACAAGCCTCCAACACCTACAGTGACTCCTCCAGCATGTTCGAGCCCTCATCCCC AGGAGCCGGAGAAGCTGATACGGAAAGTGACGACGACGATGATGATGATGACTGTAAAAAATCTTCAATGGATGAGGTGTTAACTAAGGA CCTTGAAAGGCATGCAGCTGAGTTACAAGCCCAGGAAGGATTGTCTAATGATGGAGAAACAATGGTAAATGTGCCACATATTCATGCAAG GGTGTACAACTATGAGCCTTTGACACAGCTCAAGAATGTCAGAGCAAATTACTATGGAAAATACATTGCTCTAAGAGGGACAGTGGTTCG TGTCAGTAATATAAAGCCTCTTTGCACCAAGATGGCTTTTCTTTGTGCTGCATGTGGAGAAATTCAGAGCTTTCCTCTTCCAGATGGAAA ATACAGTCTTCCCACAAAGTGTCCTGTGCCTGTGTGTCGAGGCAGGTCATTTACTGCTCTCCGCAGCTCTCCTCTCACAGTTACGATGGA CTGGCAGTCAATCAAAATCCAGGAATTGATGTCTGATGATCAGAGAGAAGCAGGTCGGATTCCACGAACAATAGAATGTGAGCTTGTTCA TGATCTTGTGGATAGCTGTGTCCCGGGAGACACAGTGACTATTACTGGAATTGTCAAAGTCTCAAATGCGGAAGAAGGTTCTCGAAATAA GAATGACAAGTGTATGTTCCTTTTGTATATTGAAGCAAATTCTATTAGTAATAGCAAAGGACAGAAAACAAAGAGTTCTGAGGATGGGTG TAAGCATGGAATGTTGATGGAGTTCTCACTTAAAGACCTTTATGCCATCCAAGAGATTCAAGCTGAAGAAAACCTGTTTAAACTCATTGT CAACTCGCTTTGCCCTGTCATTTTTGGTCATGAAGCAGCGTGCAATGTTGCCCCACGTGGCGTGTATGTTTGTGGTAACACCACGACCAC CTCTGGTCTGACGGTAACTCTTTCAAAAGATAGTTCCTCTGGAGATTTTGCTTTGGAAGCTGGTGCCCTGGTACTTGGTGATCAAGGTAT TTGTGGAATCGATGAATTTGATAAGATGGGGAATCAACATCAAGCCTTGTTGGAAGCCATGGAGCAGCAAAGTATTAGTCTTGCTAAGGC TGGTGTGGTTTGTAGCCTTCCTGCAAGAACTTCCATTATTGCTGCTGCAAATCCAGTTGGAGGACATTACAATAAAGCCAAAACAGTTTC TGAGAATTTAAAAATGGGGAGTGCACTACTATCCAGATTTGATTTGGTCTTTATCCTGTTAGATACTCCAAATGAGCATCATGATCACTT ACTCTCTGAACATGTGATTGCAATAAGAGCTGGAAAGCAGAGAACCATTAGCAGTGCCACAGTAGCTCGTATGAATAGTCAAGATTCAAA TACTTCCGTACTTGAAGTAGTTTCTGAGAAGCCATTATCAGAAAGACTAAAGGTGGTTCCTGGAGAAACAATAGATCCCATTCCCCACCA GCTATTGAGAAAGTACATTGGCTATGCTCGGCAGTATGTGTACCCAAGGCTATCCACAGAAGCTGCTCGAGTTCTTCAAGATTTTTACCT TGAGCTCCGGAAACAGAGCCAGAGGTTAAATAGCTCACCAATCACTACCAGGCAGCTGGAATCTTTGATTCGTCTGACAGAGGCACGAGC AAGGTTGGAATTGAGAGAGGAAGCAACCAAAGAAGACGCTGAGGATATAGTGGAAATTATGAAATATAGCATGCTAGGAACTTACTCTGA TGAATTTGGGAACCTAGATTTTGAGCGATCCCAGCATGGTTCTGGAATGAGCAACAGGTCAACAGCGAAAAGATTTATTTCTGCTCTCAA CAACGTTGCTGAAAGAACTTATAATAATATATTTCAATTTCATCAACTTCGGCAGATTGCCAAAGAACTAAACATTCAGGTTGCTGATTT TGAAAATTTTATTGGATCACTAAATGACCAGGGTTACCTCTTGAAAAAAGGCCCAAAAGTTTACCAGCTTCAAACTATGTAAAAGGACTT CACCAAGTTAGGGCCTCCTGGGTTTATTGCAGATTAAAGCCATCTCAGTGAAGATATGCGTGCACGCACAGACAGACAGACACACACACA CACACACACACACACACACACACACACACACACAGTCAAATACTGTTCTCTGAAAAATGATGTCCCAAAAGTATTATAATAGGAAAAAAG CATTAAATATAATAAACTAATTTAAGAAGTGATAAAGTCTCCAGATGCAGTAGCTCACACTGTAATCACAGTGACTCAGGAGGCTGAGGT GAGAGGATTCCTTGAGGCCAGGGTTCGAGACCAACCTTGGGCAACATAGCAAGACCCCATTTCTTAAAAAAAAAAAAAAAAAATTTAAAC TTAGCTGGGTATGGTGGCACATGCCTATAGTCTCAGCTACTTGTGAGGCTGAGGCAGGAGGATTCTTTGAGCCCAGGAGTTTGAGGTTAC AGTGAGCCACAATCACACCAATCACTGCACTCCAGCCTGGGCAATAAAGTAACTCTTGACTCAAAAAAATAAAAAAAATTGTAGTGGTAG CCATGTGTTAATTGTTAAATAAATTCTCCAAAGGGCTAAAAGTAAATTACTTATAAATTTTTTATAGTTGTATTTTTGACCTGCCTTTTA TATGTATGAATATTTCATAGTTTTGCATATCAGATGTAGGCATACAGACAAATACATAAACCAATGAATATATTACATATTCTGTGTTCC >65964_65964_10_PLCB1-MCM8_PLCB1_chr20_8703068_ENST00000378641_MCM8_chr20_5937772_ENST00000378883_length(amino acids)=1158AA_BP=527 MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKETELLDLSLVKDARCGRHAKAPKDPKLRELL DVGNIGRLEQRMITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSA DRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQ VQVLIEKYEPNNSLARKGQISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGV PLPSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSSSMFEPSSPGAGEADTESDDDDDDDDCKKSSMDEVLTKDLERHAAEL QAQEGLSNDGETMVNVPHIHARVYNYEPLTQLKNVRANYYGKYIALRGTVVRVSNIKPLCTKMAFLCAACGEIQSFPLPDGKYSLPTKCP VPVCRGRSFTALRSSPLTVTMDWQSIKIQELMSDDQREAGRIPRTIECELVHDLVDSCVPGDTVTITGIVKVSNAEEGSRNKNDKCMFLL YIEANSISNSKGQKTKSSEDGCKHGMLMEFSLKDLYAIQEIQAEENLFKLIVNSLCPVIFGHEAACNVAPRGVYVCGNTTTTSGLTVTLS KDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSA LLSRFDLVFILLDTPNEHHDHLLSEHVIAIRAGKQRTISSATVARMNSQDSNTSVLEVVSEKPLSERLKVVPGETIDPIPHQLLRKYIGY ARQYVYPRLSTEAARVLQDFYLELRKQSQRLNSSPITTRQLESLIRLTEARARLELREEATKEDAEDIVEIMKYSMLGTYSDEFGNLDFE -------------------------------------------------------------- >65964_65964_11_PLCB1-MCM8_PLCB1_chr20_8703068_ENST00000378641_MCM8_chr20_5937772_ENST00000378886_length(transcript)=4251nt_BP=2056nt CAGCGAGCGAGGGTGGCGGGGAAGGGGGGCGGGGGGGAGGAGGAGGGAGGAGGGAAAAGAGCGGTTAGGGGGGGCGCCGGGCGTGTGTCA CTCGCTCTCTCCCTCTGTGTATAGAGGATGTGCTGAATGGTGCGCTTTGAGGCGGCGGCGGCGGAGGAGCAGAATCCGCCGCGACTGGCA GCCTCGGCTGACCGGCTCGGCTTCTCTTCGCCTTCCGAGGCTCCTCATCCACCGCGGGCTCCAGACCTCGCGTCCCGCCCGGGGCATGGC CGGGCGCTGCGCCCCCGCGCGCTCTGCCTGCTGAGCGGCGCCGGAGGGAGGTGCGGAGGCCGGGAGGCCGGGGAGGCCGGCGGGGAGCAG AGTCGAGCGCCTCCGGAGCAGAGAAAGGAGCCCGCGCCCCGCGCCCCGCGCCCCGCGCACGGTCCCCAGTCCCTGCCGCGCTCGCCCGGG CCGCCCGGAGCCCAGATGAGCCCAGATGGCCGGGGCTCAACCCGGAGTGCACGCCTTGCAACTCAAGCCCGTGTGCGTGTCCGACAGCCT CAAGAAGGGCACCAAATTCGTCAAGTGGGATGATGACTCAACTATTGTTACTCCAATTATTTTGAGGACTGACCCTCAGGGATTTTTCTT TTACTGGACAGATCAAAACAAGGAGACAGAGCTACTGGATCTCAGCCTTGTCAAAGATGCCAGATGTGGGAGACACGCCAAAGCTCCCAA GGACCCCAAATTACGTGAACTTTTGGATGTGGGGAACATCGGGCGCCTGGAGCAGCGCATGATCACAGTGGTGTATGGGCCTGACCTCGT GAACATCTCCCATTTGAATCTCGTGGCTTTCCAAGAAGAAGTGGCCAAGGAATGGACAAATGAGGTTTTCAGTTTGGCAACAAACCTGCT GGCCCAAAACATGTCCAGGGATGCATTTCTGGAAAAAGCCTATACTAAACTTAAGCTGCAAGTCACTCCAGAAGGGCGTATTCCTCTCAA AAACATATATCGCTTGTTTTCAGCAGATCGGAAGCGAGTTGAAACTGCTTTAGAGGCTTGTAGTCTTCCATCTTCAAGGAATGATTCAAT ACCTCAAGAAGATTTCACTCCAGAAGTGTACAGAGTTTTCCTCAACAACCTTTGCCCTCGACCTGAAATTGATAACATCTTTTCAGAATT TGGTGCAAAAAGCAAACCATATCTTACCGTTGATCAGATGATGGATTTTATCAACCTTAAGCAGCGAGATCCTCGGCTTAATGAAATACT TTATCCACCTCTAAAACAAGAGCAAGTCCAAGTATTGATTGAGAAGTATGAACCCAACAACAGCCTCGCCAGAAAAGGACAAATATCAGT GGATGGGTTCATGCGCTATCTGAGTGGAGAAGAAAACGGAGTCGTTTCACCTGAGAAACTGGATTTGAATGAAGACATGTCTCAGCCCCT TTCTCACTATTTCATTAATTCCTCGCACAACACCTACCTCACAGCTGGCCAACTGGCTGGAAACTCCTCTGTTGAGATGTATCGCCAAGT GCTCCTGTCTGGTTGTCGCTGTGTGGAGCTGGACTGCTGGAAGGGACGGACTGCAGAAGAGGAACCTGTCATCACCCATGGCTTCACCAT GACAACTGAAATATCTTTCAAGGAAGTGATAGAAGCAATTGCGGAGTGTGCATTTAAGACTTCACCTTTTCCAATTCTCCTTTCGTTTGA GAACCATGTGGATTCCCCAAAGCAGCAAGCCAAGATGGCGGAGTACTGCCGACTGATCTTTGGGGATGCCCTTCTCATGGAGCCCCTGGA AAAATATCCACTGGAATCTGGAGTTCCTCTTCCAAGCCCTATGGATTTAATGTATAAAATTTTGGTGAAAAATAAGAAGAAATCACACAA GTCATCAGAAGGAAGCGGCAAAAAGAAGCTCTCAGAACAAGCCTCCAACACCTACAGTGACTCCTCCAGCATGTTCGAGCCCTCATCCCC AGGAGCCGGAGAAGCTGATACGGAAAGTGACGACGACGATGATGATGATGACTGTAAAAAATCTTCAATGGATGAGGTGTTAACTAAGGA CCTTGAAAGGCATGCAGCTGAGTTACAAGCCCAGGAAGGATTGTCTAATGATGGAGAAACAATGGTAAATGTGCCACATATTCATGCAAG GGTGTACAACTATGAGCCTTTGACACAGCTCAAGAATGTCAGAGCAAATTACTATGGAAAATACATTGCTCTAAGAGGGACAGTGGTTCG TGTCAGTAATATAAAGCCTCTTTGCACCAAGATGGCTTTTCTTTGTGCTGCATGTGGAGAAATTCAGAGCTTTCCTCTTCCAGATGGAAA ATACAGTCTTCCCACAAAGTGTCCTGTGCCTGTGTGTCGAGGCAGGTCATTTACTGCTCTCCGCAGCTCTCCTCTCACAGTTACGATGGA CTGGCAGTCAATCAAAATCCAGGAATTGATGTCTGATGATCAGAGAGAAGCAGGTCGGATTCCACGAACAATAGAATGTGAGCTTGTTCA TGATCTTGTGGATAGCTGTGTCCCGGGAGACACAGTGACTATTACTGGAATTGTCAAAGTCTCAAATGCGGAAGAAGGTTCTCGAAATAA GAATGACAAGTGTATGTTCCTTTTGTATATTGAAGCAAATTCTATTAGTAATAGCAAAGGACAGAAAACAAAGAGTTCTGAGGATGGGTG TAAGCATGGAATGTTGATGGAGTTCTCACTTAAAGACCTTTATGCCATCCAAGAGATTCAAGCTGAAGAAAACCTGTTTAAACTCATTGT CAAATGGAGTCTTGCTCTGTCGCCCAGGCTAGAGTACAGTGGTGCGATCTCAGCTCACTGCAACCTCCACCTCCCAAGTTCAAACAGTTC TCCCACCTCAGCCTGCCGAGTAGCTGGGACTACAGGCATGCGCCACCAGACCCAGCTACTTTTGCTTGTTAAAGCAGGTTTGGCATTAGC ACTCTTTGGAGGAAGCCAGAAATACGCAGATGACAAAAACAGAATTCCAATTCGGGGAGACCCCCACATCCTTGTTGTTGGAGATCCAGG CCTAGGAAAAAGTCAAATGCTACAGGCAGCGTGCAATGTTGCCCCACGTGGCGTGTATGTTTGTGGTAACACCACGACCACCTCTGGTCT GACGGTAACTCTTTCAAAAGATAGTTCCTCTGGAGATTTTGCTTTGGAAGCTGGTGCCCTGGTACTTGGTGATCAAGGTATTTGTGGAAT CGATGAATTTGATAAGATGGGGAATCAACATCAAGCCTTGTTGGAAGCCATGGAGCAGCAAAGTATTAGTCTTGCTAAGGCTGGTGTGGT TTGTAGCCTTCCTGCAAGAACTTCCATTATTGCTGCTGCAAATCCAGTTGGAGGACATTACAATAAAGCCAAAACAGTTTCTGAGAATTT AAAAATGGGGAGTGCACTACTATCCAGATTTGATTTGGTCTTTATCCTGTTAGATACTCCAAATGAGCATCATGATCACTTACTCTCTGA ACATGTGATTGCAATAAGAGCTGGAAAGCAGAGAACCATTAGCAGTGCCACAGTAGCTCGTATGAATAGTCAAGATTCAAATACTTCCGT ACTTGAAGTAGTTTCTGAGAAGCCATTATCAGAAAGACTAAAGGTGGTTCCTGGAGAAACAATAGATCCCATTCCCCACCAGCTATTGAG AAAGTACATTGGCTATGCTCGGCAGTATGTGTACCCAAGGCTATCCACAGAAGCTGCTCGAGTTCTTCAAGATTTTTACCTTGAGCTCCG GAAACAGAGCCAGAGGTTAAATAGCTCACCAATCACTACCAGGCAGCTGGAATCTTTGATTCGTCTGACAGAGGCACGAGCAAGGTTGGA ATTGAGAGAGGAAGCAACCAAAGAAGACGCTGAGGATATAGTGGAAATTATGAAATATAGCATGCTAGGAACTTACTCTGATGAATTTGG GAACCTAGATTTTGAGCGATCCCAGCATGGTTCTGGAATGAGCAACAGGTCAACAGCGAAAAGATTTATTTCTGCTCTCAACAACGTTGC TGAAAGAACTTATAATAATATATTTCAATTTCATCAACTTCGGCAGATTGCCAAAGAACTAAACATTCAGGTTGCTGATTTTGAAAATTT TATTGGATCACTAAATGACCAGGGTTACCTCTTGAAAAAAGGCCCAAAAGTTTACCAGCTTCAAACTATGTAAAAGGACTTCACCAAGTT >65964_65964_11_PLCB1-MCM8_PLCB1_chr20_8703068_ENST00000378641_MCM8_chr20_5937772_ENST00000378886_length(amino acids)=1245AA_BP=774 MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKETELLDLSLVKDARCGRHAKAPKDPKLRELL DVGNIGRLEQRMITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSA DRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQ VQVLIEKYEPNNSLARKGQISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGV PLPSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSSSMFEPSSPGAGEADTESDDDDDDDDCKKSSMDEVLTKDLERHAAEL QAQEGLSNDGETMVNVPHIHARVYNYEPLTQLKNVRANYYGKYIALRGTVVRVSNIKPLCTKMAFLCAACGEIQSFPLPDGKYSLPTKCP VPVCRGRSFTALRSSPLTVTMDWQSIKIQELMSDDQREAGRIPRTIECELVHDLVDSCVPGDTVTITGIVKVSNAEEGSRNKNDKCMFLL YIEANSISNSKGQKTKSSEDGCKHGMLMEFSLKDLYAIQEIQAEENLFKLIVKWSLALSPRLEYSGAISAHCNLHLPSSNSSPTSACRVA GTTGMRHQTQLLLLVKAGLALALFGGSQKYADDKNRIPIRGDPHILVVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTTSGLTVTLSKDS SSGDFALEAGALVLGDQGICGIDEFDKMGNQHQALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALLS RFDLVFILLDTPNEHHDHLLSEHVIAIRAGKQRTISSATVARMNSQDSNTSVLEVVSEKPLSERLKVVPGETIDPIPHQLLRKYIGYARQ YVYPRLSTEAARVLQDFYLELRKQSQRLNSSPITTRQLESLIRLTEARARLELREEATKEDAEDIVEIMKYSMLGTYSDEFGNLDFERSQ -------------------------------------------------------------- >65964_65964_12_PLCB1-MCM8_PLCB1_chr20_8703068_ENST00000378641_MCM8_chr20_5937772_ENST00000378896_length(transcript)=4908nt_BP=2056nt CAGCGAGCGAGGGTGGCGGGGAAGGGGGGCGGGGGGGAGGAGGAGGGAGGAGGGAAAAGAGCGGTTAGGGGGGGCGCCGGGCGTGTGTCA CTCGCTCTCTCCCTCTGTGTATAGAGGATGTGCTGAATGGTGCGCTTTGAGGCGGCGGCGGCGGAGGAGCAGAATCCGCCGCGACTGGCA GCCTCGGCTGACCGGCTCGGCTTCTCTTCGCCTTCCGAGGCTCCTCATCCACCGCGGGCTCCAGACCTCGCGTCCCGCCCGGGGCATGGC CGGGCGCTGCGCCCCCGCGCGCTCTGCCTGCTGAGCGGCGCCGGAGGGAGGTGCGGAGGCCGGGAGGCCGGGGAGGCCGGCGGGGAGCAG AGTCGAGCGCCTCCGGAGCAGAGAAAGGAGCCCGCGCCCCGCGCCCCGCGCCCCGCGCACGGTCCCCAGTCCCTGCCGCGCTCGCCCGGG CCGCCCGGAGCCCAGATGAGCCCAGATGGCCGGGGCTCAACCCGGAGTGCACGCCTTGCAACTCAAGCCCGTGTGCGTGTCCGACAGCCT CAAGAAGGGCACCAAATTCGTCAAGTGGGATGATGACTCAACTATTGTTACTCCAATTATTTTGAGGACTGACCCTCAGGGATTTTTCTT TTACTGGACAGATCAAAACAAGGAGACAGAGCTACTGGATCTCAGCCTTGTCAAAGATGCCAGATGTGGGAGACACGCCAAAGCTCCCAA GGACCCCAAATTACGTGAACTTTTGGATGTGGGGAACATCGGGCGCCTGGAGCAGCGCATGATCACAGTGGTGTATGGGCCTGACCTCGT GAACATCTCCCATTTGAATCTCGTGGCTTTCCAAGAAGAAGTGGCCAAGGAATGGACAAATGAGGTTTTCAGTTTGGCAACAAACCTGCT GGCCCAAAACATGTCCAGGGATGCATTTCTGGAAAAAGCCTATACTAAACTTAAGCTGCAAGTCACTCCAGAAGGGCGTATTCCTCTCAA AAACATATATCGCTTGTTTTCAGCAGATCGGAAGCGAGTTGAAACTGCTTTAGAGGCTTGTAGTCTTCCATCTTCAAGGAATGATTCAAT ACCTCAAGAAGATTTCACTCCAGAAGTGTACAGAGTTTTCCTCAACAACCTTTGCCCTCGACCTGAAATTGATAACATCTTTTCAGAATT TGGTGCAAAAAGCAAACCATATCTTACCGTTGATCAGATGATGGATTTTATCAACCTTAAGCAGCGAGATCCTCGGCTTAATGAAATACT TTATCCACCTCTAAAACAAGAGCAAGTCCAAGTATTGATTGAGAAGTATGAACCCAACAACAGCCTCGCCAGAAAAGGACAAATATCAGT GGATGGGTTCATGCGCTATCTGAGTGGAGAAGAAAACGGAGTCGTTTCACCTGAGAAACTGGATTTGAATGAAGACATGTCTCAGCCCCT TTCTCACTATTTCATTAATTCCTCGCACAACACCTACCTCACAGCTGGCCAACTGGCTGGAAACTCCTCTGTTGAGATGTATCGCCAAGT GCTCCTGTCTGGTTGTCGCTGTGTGGAGCTGGACTGCTGGAAGGGACGGACTGCAGAAGAGGAACCTGTCATCACCCATGGCTTCACCAT GACAACTGAAATATCTTTCAAGGAAGTGATAGAAGCAATTGCGGAGTGTGCATTTAAGACTTCACCTTTTCCAATTCTCCTTTCGTTTGA GAACCATGTGGATTCCCCAAAGCAGCAAGCCAAGATGGCGGAGTACTGCCGACTGATCTTTGGGGATGCCCTTCTCATGGAGCCCCTGGA AAAATATCCACTGGAATCTGGAGTTCCTCTTCCAAGCCCTATGGATTTAATGTATAAAATTTTGGTGAAAAATAAGAAGAAATCACACAA GTCATCAGAAGGAAGCGGCAAAAAGAAGCTCTCAGAACAAGCCTCCAACACCTACAGTGACTCCTCCAGCATGTTCGAGCCCTCATCCCC AGGAGCCGGAGAAGCTGATACGGAAAGTGACGACGACGATGATGATGATGACTGTAAAAAATCTTCAATGGATGAGGTGTTAACTAAGGA CCTTGAAAGGCATGCAGCTGAGTTACAAGCCCAGGAAGGATTGTCTAATGATGGAGAAACAATGGTAAATGTGCCACATATTCATGCAAG GGTGTACAACTATGAGCCTTTGACACAGCTCAAGAATGTCAGAGCAAATTACTATGGAAAATACATTGCTCTAAGAGGGACAGTGGTTCG TGTCAGTAATATAAAGCCTCTTTGCACCAAGATGGCTTTTCTTTGTGCTGCATGTGGAGAAATTCAGAGCTTTCCTCTTCCAGATGGAAA ATACAGTCTTCCCACAAAGTGTCCTGTGCCTGTGTGTCGAGGCAGGTCATTTACTGCTCTCCGCAGCTCTCCTCTCACAGTTACGATGGA CTGGCAGTCAATCAAAATCCAGGAATTGATGTCTGATGATCAGAGAGAAGCAGGTCGGATTCCACGAACAATAGAATGTGAGCTTGTTCA TGATCTTGTGGATAGCTGTGTCCCGGGAGACACAGTGACTATTACTGGAATTGTCAAAGTCTCAAATGCGGAAGAAGGTTCTCGAAATAA GAATGACAAGTGTATGTTCCTTTTGTATATTGAAGCAAATTCTATTAGTAATAGCAAAGGACAGAAAACAAAGAGTTCTGAGGATGGGTG TAAGCATGGAATGTTGATGGAGTTCTCACTTAAAGACCTTTATGCCATCCAAGAGATTCAAGCTGAAGAAAACCTGTTTAAACTCATTGT CAACTCGCTTTGCCCTGTCATTTTTGGTCATGAACTTGTTAAAGCAGGTTTGGCATTAGCACTCTTTGGAGGAAGCCAGAAATACGCAGA TGACAAAAACAGAATTCCAATTCGGGGAGACCCCCACATCCTTGTTGTTGGAGATCCAGGCCTAGGAAAAAGTCAAATGCTACAGGCAGC GTGCAATGTTGCCCCACGTGGCGTGTATGTTTGTGGTAACACCACGACCACCTCTGGTCTGACGGTAACTCTTTCAAAAGATAGTTCCTC TGGAGATTTTGCTTTGGAAGCTGGTGCCCTGGTACTTGGTGATCAAGGTATTTGTGGAATCGATGAATTTGATAAGATGGGGAATCAACA TCAAGCCTTGTTGGAAGCCATGGAGCAGCAAAGTATTAGTCTTGCTAAGGCTGGTGTGGTTTGTAGCCTTCCTGCAAGAACTTCCATTAT TGCTGCTGCAAATCCAGTTGGAGGACATTACAATAAAGCCAAAACAGTTTCTGAGAATTTAAAAATGGGGAGTGCACTACTATCCAGATT TGATTTGGTCTTTATCCTGTTAGATACTCCAAATGAGCATCATGATCACTTACTCTCTGAACATGTGATTGCAATAAGAGCTGGAAAGCA GAGAACCATTAGCAGTGCCACAGTAGCTCGTATGAATAGTCAAGATTCAAATACTTCCGTACTTGAAGTAGTTTCTGAGAAGCCATTATC AGAAAGACTAAAGGTGGTTCCTGGAGAAACAATAGATCCCATTCCCCACCAGCTATTGAGAAAGTACATTGGCTATGCTCGGCAGTATGT GTACCCAAGGCTATCCACAGAAGCTGCTCGAGTTCTTCAAGATTTTTACCTTGAGCTCCGGAAACAGAGCCAGAGGTTAAATAGCTCACC AATCACTACCAGGCAGCTGGAATCTTTGATTCGTCTGACAGAGGCACGAGCAAGGTTGGAATTGAGAGAGGAAGCAACCAAAGAAGACGC TGAGGATATAGTGGAAATTATGAAATATAGCATGCTAGGAACTTACTCTGATGAATTTGGGAACCTAGATTTTGAGCGATCCCAGCATGG TTCTGGAATGAGCAACAGGTCAACAGCGAAAAGATTTATTTCTGCTCTCAACAACGTTGCTGAAAGAACTTATAATAATATATTTCAATT TCATCAACTTCGGCAGATTGCCAAAGAACTAAACATTCAGGTTGCTGATTTTGAAAATTTTATTGGATCACTAAATGACCAGGGTTACCT CTTGAAAAAAGGCCCAAAAGTTTACCAGCTTCAAACTATGTAAAAGGACTTCACCAAGTTAGGGCCTCCTGGGTTTATTGCAGATTAAAG CCATCTCAGTGAAGATATGCGTGCACGCACAGACAGACAGACACACACACACACACACACACACACACACACACACACACACACAGTCAA ATACTGTTCTCTGAAAAATGATGTCCCAAAAGTATTATAATAGGAAAAAAGCATTAAATATAATAAACTAATTTAAGAAGTGATAAAGTC TCCAGATGCAGTAGCTCACACTGTAATCACAGTGACTCAGGAGGCTGAGGTGAGAGGATTCCTTGAGGCCAGGGTTCGAGACCAACCTTG GGCAACATAGCAAGACCCCATTTCTTAAAAAAAAAAAAAAAAAATTTAAACTTAGCTGGGTATGGTGGCACATGCCTATAGTCTCAGCTA CTTGTGAGGCTGAGGCAGGAGGATTCTTTGAGCCCAGGAGTTTGAGGTTACAGTGAGCCACAATCACACCAATCACTGCACTCCAGCCTG GGCAATAAAGTAACTCTTGACTCAAAAAAATAAAAAAAATTGTAGTGGTAGCCATGTGTTAATTGTTAAATAAATTCTCCAAAGGGCTAA AAGTAAATTACTTATAAATTTTTTATAGTTGTATTTTTGACCTGCCTTTTATATGTATGAATATTTCATAGTTTTGCATATCAGATGTAG GCATACAGACAAATACATAAACCAATGAATATATTACATATTCTGTGTTCCAATAAAACTTTATTTATGGACACTAAAATTTGAATTTCA >65964_65964_12_PLCB1-MCM8_PLCB1_chr20_8703068_ENST00000378641_MCM8_chr20_5937772_ENST00000378896_length(amino acids)=1205AA_BP=527 MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKETELLDLSLVKDARCGRHAKAPKDPKLRELL DVGNIGRLEQRMITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSA DRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQ VQVLIEKYEPNNSLARKGQISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGV PLPSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSSSMFEPSSPGAGEADTESDDDDDDDDCKKSSMDEVLTKDLERHAAEL QAQEGLSNDGETMVNVPHIHARVYNYEPLTQLKNVRANYYGKYIALRGTVVRVSNIKPLCTKMAFLCAACGEIQSFPLPDGKYSLPTKCP VPVCRGRSFTALRSSPLTVTMDWQSIKIQELMSDDQREAGRIPRTIECELVHDLVDSCVPGDTVTITGIVKVSNAEEGSRNKNDKCMFLL YIEANSISNSKGQKTKSSEDGCKHGMLMEFSLKDLYAIQEIQAEENLFKLIVNSLCPVIFGHELVKAGLALALFGGSQKYADDKNRIPIR GDPHILVVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTTSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQALLEAME QQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEHHDHLLSEHVIAIRAGKQRTISSATV ARMNSQDSNTSVLEVVSEKPLSERLKVVPGETIDPIPHQLLRKYIGYARQYVYPRLSTEAARVLQDFYLELRKQSQRLNSSPITTRQLES LIRLTEARARLELREEATKEDAEDIVEIMKYSMLGTYSDEFGNLDFERSQHGSGMSNRSTAKRFISALNNVAERTYNNIFQFHQLRQIAK -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for PLCB1-MCM8 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for PLCB1-MCM8 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for PLCB1-MCM8 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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