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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PLCB2-EPN1 (FusionGDB2 ID:65980)

Fusion Gene Summary for PLCB2-EPN1

check button Fusion gene summary
Fusion gene informationFusion gene name: PLCB2-EPN1
Fusion gene ID: 65980
HgeneTgene
Gene symbol

PLCB2

EPN1

Gene ID

5330

29924

Gene namephospholipase C beta 2epsin 1
SynonymsPLC-beta-2-
Cytomap

15q15.1

19q13.42

Type of geneprotein-codingprotein-coding
Description1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2phosphoinositide phospholipase C-beta-2epsin-1EH domain-binding mitotic phosphoproteinEPS-15-interacting protein 1
Modification date2020032020200313
UniProtAcc.

Q9Y6I3

Ensembl transtripts involved in fusion geneENST00000260402, ENST00000456256, 
ENST00000557821, ENST00000543785, 
ENST00000591743, ENST00000411543, 
ENST00000085079, ENST00000270460, 
Fusion gene scores* DoF score5 X 5 X 3=757 X 5 X 6=210
# samples 58
** MAII scorelog2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/210*10)=-1.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PLCB2 [Title/Abstract] AND EPN1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPLCB2(40584049)-EPN1(56206513), # samples:2
Anticipated loss of major functional domain due to fusion event.PLCB2-EPN1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
PLCB2-EPN1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PLCB2-EPN1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PLCB2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across EPN1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-L7-A56GPLCB2chr15

40584049

-EPN1chr19

56206513

+


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Fusion Gene ORF analysis for PLCB2-EPN1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000260402ENST00000591743PLCB2chr15

40584049

-EPN1chr19

56206513

+
5CDS-intronENST00000456256ENST00000591743PLCB2chr15

40584049

-EPN1chr19

56206513

+
5CDS-intronENST00000557821ENST00000591743PLCB2chr15

40584049

-EPN1chr19

56206513

+
Frame-shiftENST00000260402ENST00000411543PLCB2chr15

40584049

-EPN1chr19

56206513

+
Frame-shiftENST00000456256ENST00000411543PLCB2chr15

40584049

-EPN1chr19

56206513

+
Frame-shiftENST00000557821ENST00000411543PLCB2chr15

40584049

-EPN1chr19

56206513

+
In-frameENST00000260402ENST00000085079PLCB2chr15

40584049

-EPN1chr19

56206513

+
In-frameENST00000260402ENST00000270460PLCB2chr15

40584049

-EPN1chr19

56206513

+
In-frameENST00000456256ENST00000085079PLCB2chr15

40584049

-EPN1chr19

56206513

+
In-frameENST00000456256ENST00000270460PLCB2chr15

40584049

-EPN1chr19

56206513

+
In-frameENST00000557821ENST00000085079PLCB2chr15

40584049

-EPN1chr19

56206513

+
In-frameENST00000557821ENST00000270460PLCB2chr15

40584049

-EPN1chr19

56206513

+
intron-3CDSENST00000543785ENST00000085079PLCB2chr15

40584049

-EPN1chr19

56206513

+
intron-3CDSENST00000543785ENST00000270460PLCB2chr15

40584049

-EPN1chr19

56206513

+
intron-3CDSENST00000543785ENST00000411543PLCB2chr15

40584049

-EPN1chr19

56206513

+
intron-intronENST00000543785ENST00000591743PLCB2chr15

40584049

-EPN1chr19

56206513

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000260402PLCB2chr1540584049-ENST00000270460EPN1chr1956206513+347128521813060959
ENST00000260402PLCB2chr1540584049-ENST00000085079EPN1chr1956206513+347128521813060959
ENST00000557821PLCB2chr1540584049-ENST00000270460EPN1chr1956206513+33742755962963955
ENST00000557821PLCB2chr1540584049-ENST00000085079EPN1chr1956206513+33742755962963955
ENST00000456256PLCB2chr1540584049-ENST00000270460EPN1chr1956206513+33742755842963959
ENST00000456256PLCB2chr1540584049-ENST00000085079EPN1chr1956206513+33742755842963959

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000260402ENST00000270460PLCB2chr1540584049-EPN1chr1956206513+0.0032946940.99670535
ENST00000260402ENST00000085079PLCB2chr1540584049-EPN1chr1956206513+0.0032946940.99670535
ENST00000557821ENST00000270460PLCB2chr1540584049-EPN1chr1956206513+0.0032742760.9967257
ENST00000557821ENST00000085079PLCB2chr1540584049-EPN1chr1956206513+0.0032742760.9967257
ENST00000456256ENST00000270460PLCB2chr1540584049-EPN1chr1956206513+0.0032329160.99676704
ENST00000456256ENST00000085079PLCB2chr1540584049-EPN1chr1956206513+0.0032329160.99676704

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Fusion Genomic Features for PLCB2-EPN1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PLCB2chr1540584049-EPN1chr1956206513+0.99841630.001583667
PLCB2chr1540584049-EPN1chr1956206513+0.99841630.001583667

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PLCB2-EPN1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:40584049/chr19:56206513)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.EPN1

Q9Y6I3

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis. {ECO:0000250, ECO:0000269|PubMed:10557078}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePLCB2chr15:40584049chr19:56206513ENST00000260402-2432500_5458671186.0Compositional biasNote=Glu-rich
HgenePLCB2chr15:40584049chr19:56206513ENST00000557821-2432500_5458631182.0Compositional biasNote=Glu-rich
HgenePLCB2chr15:40584049chr19:56206513ENST00000260402-2432312_4638671186.0DomainPI-PLC X-box
HgenePLCB2chr15:40584049chr19:56206513ENST00000260402-2432546_6628671186.0DomainPI-PLC Y-box
HgenePLCB2chr15:40584049chr19:56206513ENST00000260402-2432662_7908671186.0DomainC2
HgenePLCB2chr15:40584049chr19:56206513ENST00000557821-2432312_4638631182.0DomainPI-PLC X-box
HgenePLCB2chr15:40584049chr19:56206513ENST00000557821-2432546_6628631182.0DomainPI-PLC Y-box
HgenePLCB2chr15:40584049chr19:56206513ENST00000557821-2432662_7908631182.0DomainC2
TgeneEPN1chr15:40584049chr19:56206513ENST00000085079810502_574481551.0RegionNote=3 X 3 AA repeats of N-P-F
TgeneEPN1chr15:40584049chr19:56206513ENST00000085079810502_504481551.0RepeatNote=1
TgeneEPN1chr15:40584049chr19:56206513ENST00000085079810518_520481551.0RepeatNote=2
TgeneEPN1chr15:40584049chr19:56206513ENST00000085079810572_574481551.0RepeatNote=3
TgeneEPN1chr15:40584049chr19:56206513ENST00000270460911518_520507577.0RepeatNote=2
TgeneEPN1chr15:40584049chr19:56206513ENST00000270460911572_574507577.0RepeatNote=3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePLCB2chr15:40584049chr19:56206513ENST00000260402-2432988_11478671186.0Coiled coilOntology_term=ECO:0000255
HgenePLCB2chr15:40584049chr19:56206513ENST00000557821-2432988_11478631182.0Coiled coilOntology_term=ECO:0000255
TgeneEPN1chr15:40584049chr19:56206513ENST00000085079810267_573481551.0Compositional biasNote=Ala/Gly/Pro-rich
TgeneEPN1chr15:40584049chr19:56206513ENST00000270460911267_573507577.0Compositional biasNote=Ala/Gly/Pro-rich
TgeneEPN1chr15:40584049chr19:56206513ENST00000411543911267_573593663.0Compositional biasNote=Ala/Gly/Pro-rich
TgeneEPN1chr15:40584049chr19:56206513ENST0000008507981012_144481551.0DomainENTH
TgeneEPN1chr15:40584049chr19:56206513ENST00000085079810183_202481551.0DomainUIM 1
TgeneEPN1chr15:40584049chr19:56206513ENST00000085079810208_227481551.0DomainUIM 2
TgeneEPN1chr15:40584049chr19:56206513ENST00000085079810233_252481551.0DomainUIM 3
TgeneEPN1chr15:40584049chr19:56206513ENST0000027046091112_144507577.0DomainENTH
TgeneEPN1chr15:40584049chr19:56206513ENST00000270460911183_202507577.0DomainUIM 1
TgeneEPN1chr15:40584049chr19:56206513ENST00000270460911208_227507577.0DomainUIM 2
TgeneEPN1chr15:40584049chr19:56206513ENST00000270460911233_252507577.0DomainUIM 3
TgeneEPN1chr15:40584049chr19:56206513ENST0000041154391112_144593663.0DomainENTH
TgeneEPN1chr15:40584049chr19:56206513ENST00000411543911183_202593663.0DomainUIM 1
TgeneEPN1chr15:40584049chr19:56206513ENST00000411543911208_227593663.0DomainUIM 2
TgeneEPN1chr15:40584049chr19:56206513ENST00000411543911233_252593663.0DomainUIM 3
TgeneEPN1chr15:40584049chr19:56206513ENST00000085079810402_411481551.0MotifNote=[DE]-X(1%2C2)-F-X-X-[FL]-X-X-X-R motif
TgeneEPN1chr15:40584049chr19:56206513ENST00000270460911402_411507577.0MotifNote=[DE]-X(1%2C2)-F-X-X-[FL]-X-X-X-R motif
TgeneEPN1chr15:40584049chr19:56206513ENST00000411543911402_411593663.0MotifNote=[DE]-X(1%2C2)-F-X-X-[FL]-X-X-X-R motif
TgeneEPN1chr15:40584049chr19:56206513ENST00000085079810274_379481551.0RegionNote=8 X 3 AA repeats of [ED]-P-W
TgeneEPN1chr15:40584049chr19:56206513ENST00000270460911274_379507577.0RegionNote=8 X 3 AA repeats of [ED]-P-W
TgeneEPN1chr15:40584049chr19:56206513ENST00000270460911502_574507577.0RegionNote=3 X 3 AA repeats of N-P-F
TgeneEPN1chr15:40584049chr19:56206513ENST00000411543911274_379593663.0RegionNote=8 X 3 AA repeats of [ED]-P-W
TgeneEPN1chr15:40584049chr19:56206513ENST00000411543911502_574593663.0RegionNote=3 X 3 AA repeats of N-P-F
TgeneEPN1chr15:40584049chr19:56206513ENST00000085079810274_276481551.0RepeatNote=1
TgeneEPN1chr15:40584049chr19:56206513ENST00000085079810294_296481551.0RepeatNote=2
TgeneEPN1chr15:40584049chr19:56206513ENST00000085079810306_308481551.0RepeatNote=3
TgeneEPN1chr15:40584049chr19:56206513ENST00000085079810319_321481551.0RepeatNote=4
TgeneEPN1chr15:40584049chr19:56206513ENST00000085079810332_334481551.0RepeatNote=5
TgeneEPN1chr15:40584049chr19:56206513ENST00000085079810349_351481551.0RepeatNote=6
TgeneEPN1chr15:40584049chr19:56206513ENST00000085079810367_369481551.0RepeatNote=7
TgeneEPN1chr15:40584049chr19:56206513ENST00000085079810377_379481551.0RepeatNote=8
TgeneEPN1chr15:40584049chr19:56206513ENST00000270460911274_276507577.0RepeatNote=1
TgeneEPN1chr15:40584049chr19:56206513ENST00000270460911294_296507577.0RepeatNote=2
TgeneEPN1chr15:40584049chr19:56206513ENST00000270460911306_308507577.0RepeatNote=3
TgeneEPN1chr15:40584049chr19:56206513ENST00000270460911319_321507577.0RepeatNote=4
TgeneEPN1chr15:40584049chr19:56206513ENST00000270460911332_334507577.0RepeatNote=5
TgeneEPN1chr15:40584049chr19:56206513ENST00000270460911349_351507577.0RepeatNote=6
TgeneEPN1chr15:40584049chr19:56206513ENST00000270460911367_369507577.0RepeatNote=7
TgeneEPN1chr15:40584049chr19:56206513ENST00000270460911377_379507577.0RepeatNote=8
TgeneEPN1chr15:40584049chr19:56206513ENST00000270460911502_504507577.0RepeatNote=1
TgeneEPN1chr15:40584049chr19:56206513ENST00000411543911274_276593663.0RepeatNote=1
TgeneEPN1chr15:40584049chr19:56206513ENST00000411543911294_296593663.0RepeatNote=2
TgeneEPN1chr15:40584049chr19:56206513ENST00000411543911306_308593663.0RepeatNote=3
TgeneEPN1chr15:40584049chr19:56206513ENST00000411543911319_321593663.0RepeatNote=4
TgeneEPN1chr15:40584049chr19:56206513ENST00000411543911332_334593663.0RepeatNote=5
TgeneEPN1chr15:40584049chr19:56206513ENST00000411543911349_351593663.0RepeatNote=6
TgeneEPN1chr15:40584049chr19:56206513ENST00000411543911367_369593663.0RepeatNote=7
TgeneEPN1chr15:40584049chr19:56206513ENST00000411543911377_379593663.0RepeatNote=8
TgeneEPN1chr15:40584049chr19:56206513ENST00000411543911502_504593663.0RepeatNote=1
TgeneEPN1chr15:40584049chr19:56206513ENST00000411543911518_520593663.0RepeatNote=2
TgeneEPN1chr15:40584049chr19:56206513ENST00000411543911572_574593663.0RepeatNote=3


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Fusion Gene Sequence for PLCB2-EPN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>65980_65980_1_PLCB2-EPN1_PLCB2_chr15_40584049_ENST00000260402_EPN1_chr19_56206513_ENST00000085079_length(transcript)=3471nt_BP=2852nt
ACAGGCCCCCATGGCAGGCAGGGCGGGTGGGAGGAGGGTGATTTACAAGGCAGATGGGCCTCTGGCTACAGCTCAGTCCTGCACTCAGCC
AGGGCCACCCCAGGGGCTATAAGAGCAACTAGATTTCTGGAGCAGCTCGGGGATGGGTGCCATTTGAGCCCAGCTTGGCTCCCCCTCCTG
GCTGGCCTCCTTCCTGCCCTTCTGCCTGCCTGTGTCTGCTGAGATTCTGCAAAGAGGAACGCTTGGCACCATGTCTCTGCTCAACCCTGT
CCTGCTGCCCCCCAAGGTGAAGGCCTATCTGAGCCAAGGGGAGCGCTTCATCAAATGGGATGATGAAACTACAGTTGCCTCTCCAGTTAT
CCTCCGTGTGGATCCTAAGGGCTACTACTTATACTGGACGTATCAAAGTAAGGAGATGGAGTTTCTGGATATCACCAGCATCCGGGATAC
TCGCTTTGGGAAGTTTGCCAAGATGCCCAAGAGCCAGAAGCTCCGGGACGTCTTCAACATGGACTTTCCTGATAACAGTTTCCTGCTGAA
GACACTCACGGTGGTGTCCGGCCCGGACATGGTGGACCTCACCTTCCACAACTTCGTCTCCTACAAGGAGAACGTGGGCAAGGCCTGGGC
TGAGGACGTACTGGCCCTAGTCAAACATCCGCTGACGGCCAACGCCTCCCGCAGCACCTTCCTGGACAAGATCCTTGTGAAGCTCAAGAT
GCAGCTCAACTCTGAAGGGAAGATTCCGGTGAAGAACTTTTTCCAGATGTTTCCTGCTGACCGCAAGCGGGTGGAAGCTGCTCTCAGTGC
CTGCCACCTCCCCAAAGGCAAAAATGACGCCATCAATCCTGAGGACTTCCCAGAACCTGTCTACAAGAGTTTCCTCATGAGCCTCTGTCC
TCGGCCAGAAATAGATGAGATCTTCACTTCTTACCATGCTAAGGCCAAACCCTACATGACGAAGGAGCACCTGACCAAATTCATCAACCA
GAAACAGCGGGACTCCCGGCTTAACTCCCTGCTGTTCCCGCCAGCACGGCCTGACCAGGTGCAGGGCCTCATCGACAAGTATGAGCCCAG
TGGCATCAATGCACAGAGGGGCCAGCTGTCACCTGAAGGCATGGTCTGGTTTCTCTGTGGGCCAGAGAACAGCGTGCTGGCCCAGGACAA
GCTGCTGCTCCACCACGACATGACGCAGCCACTCAATCATTACTTCATCAACTCGTCCCACAACACCTACCTGACAGCCGGCCAGTTCTC
AGGCCTCTCCTCGGCTGAGATGTACCGCCAGGTGCTGCTCTCTGGCTGCCGTTGCGTGGAGCTAGACTGCTGGAAGGGGAAACCCCCTGA
CGAGGAGCCCATTATCACCCATGGCTTCACCATGACCACAGACATCTTCTTCAAAGAAGCAATTGAGGCTATTGCAGAAAGCGCCTTTAA
GACCTCCCCCTATCCCATCATCCTGTCGTTTGAGAACCATGTGGACTCACCCCGCCAGCAGGCTAAGATGGCTGAGTATTGCCGGACGAT
CTTTGGGGATATGCTGCTCACAGAGCCCCTGGAAAAGTTCCCACTAAAACCAGGTGTCCCCCTGCCCAGCCCTGAGGATCTCAGGGGCAA
GATCCTCATCAAGAACAAGAAGAACCAGTTTTCTGGCCCCACCTCCTCCAGTAAGGATACTGGTGGGGAGGCTGAGGGCAGCAGCCCACC
CAGTGCCCCTGCAGGTGAGGGCACAGTGTGGGCTGGCGAGGAAGGGACTGAGCTGGAGGAGGAGGAGGTGGAAGAGGAAGAGGAGGAGGA
GTCAGGAAACCTGGATGAAGAAGAGATTAAGAAGATGCAGTCGGATGAGGGCACAGCGGGCCTGGAAGTGACGGCTTATGAGGAGATGTC
CAGCCTAGTCAATTACATCCAGCCCACCAAGTTCGTCTCCTTTGAGTTCTCTGCCCAAAAGAACCGAAGTTATGTCATCTCGTCCTTCAC
AGAGCTCAAGGCATATGACCTGCTCTCCAAGGCCTCGGTGCAGTTTGTGGACTACAACAAGCGCCAGATGAGCCGCATTTACCCCAAGGG
AACCCGCATGGACTCCTCCAACTACATGCCCCAGATGTTCTGGAATGCTGGATGCCAGATGGTTGCCCTCAACTTCCAGACGATGGACTT
GCCCATGCAGCAGAACATGGCAGTATTTGAGTTCAACGGGCAGAGCGGCTACCTCCTCAAGCATGAGTTCATGCGCCGGCCGGACAAGCA
GTTCAACCCCTTCTCAGTGGACCGCATCGACGTGGTGGTGGCCACCACCCTTTCCATTACGGTGATCTCTGGGCAGTTCCTGTCAGAACG
CAGCGTGCGCACCTATGTAGAAGTGGAGCTGTTTGGCCTTCCTGGGGACCCCAAGAGGCGCTATCGAACTAAGCTGTCACCCAGTACTAA
CTCCATCAATCCTGTCTGGAAGGAGGAGCCCTTTGTCTTTGAGAAGATCTTGATGCCTGAGCTGGCCTCCCTCAGAGTGGCTGTGATGGA
GGAAGGCAACAAGTTTCTTGGACACCGCATCATCCCCATCAATGCCCTAAATTCTGGGTACCACCACCTGTGCCTGCACAGTGAGAGCAA
CATGCCCCTCACCATGCCTGCGCTCTTCATCTTCCTGGAGATGAAGGACTACATACCTGGTGCTTGGGCAGATCTCACTGTGGCCCTCGC
CAACCCCATTAAGTTCTTCAGTGCCCATGACACGAAGTCTGTGAAGCTCAAGGAGGCCATGGGAGGTCTGCCTGAGAAGCCCTTCCCACT
GGCGAGTCCAGTTGCCAGCCAGGTCAATGGGGCGTTGGCCCCAACGAGCAATGGGTCACCAGGAGGCCCAGCCACTGGCCCTTCCGTCAC
CAACCCCTTCCAGCCCGCGCCTCCCGCGACGCTCACCCTGAACCAGCTCCGTCTCAGTCCTGTGCCTCCCGTCCCTGGAGCGCCACCCAC
GTACATCTCTCCCCTTGGCGGGGGCCCTGGCCTGCCCCCCATGATGCCCCCGGGCCCCCCGGCCCCCAACACTAATCCCTTCCTCCTATA
ATCCAGGGCGGAAGGGGGCCTGGCTCCATCCGGCTGCCCCATTCCGGCTCCCTGGGAGATCAGTGTTGTGAGTGCATGTGAAATGGGGGA
TCCCCACCCCCAGTGCCCTTCCCCTTCCTGGGGCCCACTCACACTACACCCTCTTCCTTTCCCACCCCACCTCCCCGGAGAGAAACTGGA
CATGGGGCCTGGGGAGGGGAGCTGGCCAGAGGAGGACCCCTTTCCCGTGGCATTAGAAGGGGGAGGGGTGGCTGGGGCCCCCACCCATTC
CCCCTCCCTCCAAACTCCCAACCCCCAGTCAGTGTTTGAGCCTCCTCGTTCCCCTCACGCACCCGCTCACGCACCCTCGGTGAATCCTTG

>65980_65980_1_PLCB2-EPN1_PLCB2_chr15_40584049_ENST00000260402_EPN1_chr19_56206513_ENST00000085079_length(amino acids)=959AA_BP=890
MASFLPFCLPVSAEILQRGTLGTMSLLNPVLLPPKVKAYLSQGERFIKWDDETTVASPVILRVDPKGYYLYWTYQSKEMEFLDITSIRDT
RFGKFAKMPKSQKLRDVFNMDFPDNSFLLKTLTVVSGPDMVDLTFHNFVSYKENVGKAWAEDVLALVKHPLTANASRSTFLDKILVKLKM
QLNSEGKIPVKNFFQMFPADRKRVEAALSACHLPKGKNDAINPEDFPEPVYKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEHLTKFINQ
KQRDSRLNSLLFPPARPDQVQGLIDKYEPSGINAQRGQLSPEGMVWFLCGPENSVLAQDKLLLHHDMTQPLNHYFINSSHNTYLTAGQFS
GLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDIFFKEAIEAIAESAFKTSPYPIILSFENHVDSPRQQAKMAEYCRTI
FGDMLLTEPLEKFPLKPGVPLPSPEDLRGKILIKNKKNQFSGPTSSSKDTGGEAEGSSPPSAPAGEGTVWAGEEGTELEEEEVEEEEEEE
SGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFVSFEFSAQKNRSYVISSFTELKAYDLLSKASVQFVDYNKRQMSRIYPKG
TRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMAVFEFNGQSGYLLKHEFMRRPDKQFNPFSVDRIDVVVATTLSITVISGQFLSER
SVRTYVEVELFGLPGDPKRRYRTKLSPSTNSINPVWKEEPFVFEKILMPELASLRVAVMEEGNKFLGHRIIPINALNSGYHHLCLHSESN
MPLTMPALFIFLEMKDYIPGAWADLTVALANPIKFFSAHDTKSVKLKEAMGGLPEKPFPLASPVASQVNGALAPTSNGSPGGPATGPSVT

--------------------------------------------------------------
>65980_65980_2_PLCB2-EPN1_PLCB2_chr15_40584049_ENST00000260402_EPN1_chr19_56206513_ENST00000270460_length(transcript)=3471nt_BP=2852nt
ACAGGCCCCCATGGCAGGCAGGGCGGGTGGGAGGAGGGTGATTTACAAGGCAGATGGGCCTCTGGCTACAGCTCAGTCCTGCACTCAGCC
AGGGCCACCCCAGGGGCTATAAGAGCAACTAGATTTCTGGAGCAGCTCGGGGATGGGTGCCATTTGAGCCCAGCTTGGCTCCCCCTCCTG
GCTGGCCTCCTTCCTGCCCTTCTGCCTGCCTGTGTCTGCTGAGATTCTGCAAAGAGGAACGCTTGGCACCATGTCTCTGCTCAACCCTGT
CCTGCTGCCCCCCAAGGTGAAGGCCTATCTGAGCCAAGGGGAGCGCTTCATCAAATGGGATGATGAAACTACAGTTGCCTCTCCAGTTAT
CCTCCGTGTGGATCCTAAGGGCTACTACTTATACTGGACGTATCAAAGTAAGGAGATGGAGTTTCTGGATATCACCAGCATCCGGGATAC
TCGCTTTGGGAAGTTTGCCAAGATGCCCAAGAGCCAGAAGCTCCGGGACGTCTTCAACATGGACTTTCCTGATAACAGTTTCCTGCTGAA
GACACTCACGGTGGTGTCCGGCCCGGACATGGTGGACCTCACCTTCCACAACTTCGTCTCCTACAAGGAGAACGTGGGCAAGGCCTGGGC
TGAGGACGTACTGGCCCTAGTCAAACATCCGCTGACGGCCAACGCCTCCCGCAGCACCTTCCTGGACAAGATCCTTGTGAAGCTCAAGAT
GCAGCTCAACTCTGAAGGGAAGATTCCGGTGAAGAACTTTTTCCAGATGTTTCCTGCTGACCGCAAGCGGGTGGAAGCTGCTCTCAGTGC
CTGCCACCTCCCCAAAGGCAAAAATGACGCCATCAATCCTGAGGACTTCCCAGAACCTGTCTACAAGAGTTTCCTCATGAGCCTCTGTCC
TCGGCCAGAAATAGATGAGATCTTCACTTCTTACCATGCTAAGGCCAAACCCTACATGACGAAGGAGCACCTGACCAAATTCATCAACCA
GAAACAGCGGGACTCCCGGCTTAACTCCCTGCTGTTCCCGCCAGCACGGCCTGACCAGGTGCAGGGCCTCATCGACAAGTATGAGCCCAG
TGGCATCAATGCACAGAGGGGCCAGCTGTCACCTGAAGGCATGGTCTGGTTTCTCTGTGGGCCAGAGAACAGCGTGCTGGCCCAGGACAA
GCTGCTGCTCCACCACGACATGACGCAGCCACTCAATCATTACTTCATCAACTCGTCCCACAACACCTACCTGACAGCCGGCCAGTTCTC
AGGCCTCTCCTCGGCTGAGATGTACCGCCAGGTGCTGCTCTCTGGCTGCCGTTGCGTGGAGCTAGACTGCTGGAAGGGGAAACCCCCTGA
CGAGGAGCCCATTATCACCCATGGCTTCACCATGACCACAGACATCTTCTTCAAAGAAGCAATTGAGGCTATTGCAGAAAGCGCCTTTAA
GACCTCCCCCTATCCCATCATCCTGTCGTTTGAGAACCATGTGGACTCACCCCGCCAGCAGGCTAAGATGGCTGAGTATTGCCGGACGAT
CTTTGGGGATATGCTGCTCACAGAGCCCCTGGAAAAGTTCCCACTAAAACCAGGTGTCCCCCTGCCCAGCCCTGAGGATCTCAGGGGCAA
GATCCTCATCAAGAACAAGAAGAACCAGTTTTCTGGCCCCACCTCCTCCAGTAAGGATACTGGTGGGGAGGCTGAGGGCAGCAGCCCACC
CAGTGCCCCTGCAGGTGAGGGCACAGTGTGGGCTGGCGAGGAAGGGACTGAGCTGGAGGAGGAGGAGGTGGAAGAGGAAGAGGAGGAGGA
GTCAGGAAACCTGGATGAAGAAGAGATTAAGAAGATGCAGTCGGATGAGGGCACAGCGGGCCTGGAAGTGACGGCTTATGAGGAGATGTC
CAGCCTAGTCAATTACATCCAGCCCACCAAGTTCGTCTCCTTTGAGTTCTCTGCCCAAAAGAACCGAAGTTATGTCATCTCGTCCTTCAC
AGAGCTCAAGGCATATGACCTGCTCTCCAAGGCCTCGGTGCAGTTTGTGGACTACAACAAGCGCCAGATGAGCCGCATTTACCCCAAGGG
AACCCGCATGGACTCCTCCAACTACATGCCCCAGATGTTCTGGAATGCTGGATGCCAGATGGTTGCCCTCAACTTCCAGACGATGGACTT
GCCCATGCAGCAGAACATGGCAGTATTTGAGTTCAACGGGCAGAGCGGCTACCTCCTCAAGCATGAGTTCATGCGCCGGCCGGACAAGCA
GTTCAACCCCTTCTCAGTGGACCGCATCGACGTGGTGGTGGCCACCACCCTTTCCATTACGGTGATCTCTGGGCAGTTCCTGTCAGAACG
CAGCGTGCGCACCTATGTAGAAGTGGAGCTGTTTGGCCTTCCTGGGGACCCCAAGAGGCGCTATCGAACTAAGCTGTCACCCAGTACTAA
CTCCATCAATCCTGTCTGGAAGGAGGAGCCCTTTGTCTTTGAGAAGATCTTGATGCCTGAGCTGGCCTCCCTCAGAGTGGCTGTGATGGA
GGAAGGCAACAAGTTTCTTGGACACCGCATCATCCCCATCAATGCCCTAAATTCTGGGTACCACCACCTGTGCCTGCACAGTGAGAGCAA
CATGCCCCTCACCATGCCTGCGCTCTTCATCTTCCTGGAGATGAAGGACTACATACCTGGTGCTTGGGCAGATCTCACTGTGGCCCTCGC
CAACCCCATTAAGTTCTTCAGTGCCCATGACACGAAGTCTGTGAAGCTCAAGGAGGCCATGGGAGGTCTGCCTGAGAAGCCCTTCCCACT
GGCGAGTCCAGTTGCCAGCCAGGTCAATGGGGCGTTGGCCCCAACGAGCAATGGGTCACCAGGAGGCCCAGCCACTGGCCCTTCCGTCAC
CAACCCCTTCCAGCCCGCGCCTCCCGCGACGCTCACCCTGAACCAGCTCCGTCTCAGTCCTGTGCCTCCCGTCCCTGGAGCGCCACCCAC
GTACATCTCTCCCCTTGGCGGGGGCCCTGGCCTGCCCCCCATGATGCCCCCGGGCCCCCCGGCCCCCAACACTAATCCCTTCCTCCTATA
ATCCAGGGCGGAAGGGGGCCTGGCTCCATCCGGCTGCCCCATTCCGGCTCCCTGGGAGATCAGTGTTGTGAGTGCATGTGAAATGGGGGA
TCCCCACCCCCAGTGCCCTTCCCCTTCCTGGGGCCCACTCACACTACACCCTCTTCCTTTCCCACCCCACCTCCCCGGAGAGAAACTGGA
CATGGGGCCTGGGGAGGGGAGCTGGCCAGAGGAGGACCCCTTTCCCGTGGCATTAGAAGGGGGAGGGGTGGCTGGGGCCCCCACCCATTC
CCCCTCCCTCCAAACTCCCAACCCCCAGTCAGTGTTTGAGCCTCCTCGTTCCCCTCACGCACCCGCTCACGCACCCTCGGTGAATCCTTG

>65980_65980_2_PLCB2-EPN1_PLCB2_chr15_40584049_ENST00000260402_EPN1_chr19_56206513_ENST00000270460_length(amino acids)=959AA_BP=890
MASFLPFCLPVSAEILQRGTLGTMSLLNPVLLPPKVKAYLSQGERFIKWDDETTVASPVILRVDPKGYYLYWTYQSKEMEFLDITSIRDT
RFGKFAKMPKSQKLRDVFNMDFPDNSFLLKTLTVVSGPDMVDLTFHNFVSYKENVGKAWAEDVLALVKHPLTANASRSTFLDKILVKLKM
QLNSEGKIPVKNFFQMFPADRKRVEAALSACHLPKGKNDAINPEDFPEPVYKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEHLTKFINQ
KQRDSRLNSLLFPPARPDQVQGLIDKYEPSGINAQRGQLSPEGMVWFLCGPENSVLAQDKLLLHHDMTQPLNHYFINSSHNTYLTAGQFS
GLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDIFFKEAIEAIAESAFKTSPYPIILSFENHVDSPRQQAKMAEYCRTI
FGDMLLTEPLEKFPLKPGVPLPSPEDLRGKILIKNKKNQFSGPTSSSKDTGGEAEGSSPPSAPAGEGTVWAGEEGTELEEEEVEEEEEEE
SGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFVSFEFSAQKNRSYVISSFTELKAYDLLSKASVQFVDYNKRQMSRIYPKG
TRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMAVFEFNGQSGYLLKHEFMRRPDKQFNPFSVDRIDVVVATTLSITVISGQFLSER
SVRTYVEVELFGLPGDPKRRYRTKLSPSTNSINPVWKEEPFVFEKILMPELASLRVAVMEEGNKFLGHRIIPINALNSGYHHLCLHSESN
MPLTMPALFIFLEMKDYIPGAWADLTVALANPIKFFSAHDTKSVKLKEAMGGLPEKPFPLASPVASQVNGALAPTSNGSPGGPATGPSVT

--------------------------------------------------------------
>65980_65980_3_PLCB2-EPN1_PLCB2_chr15_40584049_ENST00000456256_EPN1_chr19_56206513_ENST00000085079_length(transcript)=3374nt_BP=2755nt
CCCCAGGGGCTATAAGAGCAACTAGATTTCTGGAGCAGCTCGGGGATGGGTGCCATTTGAGCCCAGCTTGGCTCCCCCTCCTGGCTGGCC
TCCTTCCTGCCCTTCTGCCTGCCTGTGTCTGCTGAGATTCTGCAAAGAGGAACGCTTGGCACCATGTCTCTGCTCAACCCTGTCCTGCTG
CCCCCCAAGGTGAAGGCCTATCTGAGCCAAGGGGAGCGCTTCATCAAATGGGATGATGAAACTACAGTTGCCTCTCCAGTTATCCTCCGT
GTGGATCCTAAGGGCTACTACTTATACTGGACGTATCAAAGTAAGGAGATGGAGTTTCTGGATATCACCAGCATCCGGGATACTCGCTTT
GGGAAGTTTGCCAAGATGCCCAAGAGCCAGAAGCTCCGGGACGTCTTCAACATGGACTTTCCTGATAACAGTTTCCTGCTGAAGACACTC
ACGGTGGTGTCCGGCCCGGACATGGTGGACCTCACCTTCCACAACTTCGTCTCCTACAAGGAGAACGTGGGCAAGGCCTGGGCTGAGGAC
GTACTGGCCCTAGTCAAACATCCGCTGACGGCCAACGCCTCCCGCAGCACCTTCCTGGACAAGATCCTTGTGAAGCTCAAGATGCAGCTC
AACTCTGAAGGGAAGATTCCGGTGAAGAACTTTTTCCAGATGTTTCCTGCTGACCGCAAGCGGGTGGAAGCTGCTCTCAGTGCCTGCCAC
CTCCCCAAAGGCAAAAATGACGCCATCAATCCTGAGGACTTCCCAGAACCTGTCTACAAGAGTTTCCTCATGAGCCTCTGTCCTCGGCCA
GAAATAGATGAGATCTTCACTTCTTACCATGCTAAGGCCAAACCCTACATGACGAAGGAGCACCTGACCAAATTCATCAACCAGAAACAG
CGGGACTCCCGGCTTAACTCCCTGCTGTTCCCGCCAGCACGGCCTGACCAGGTGCAGGGCCTCATCGACAAGTATGAGCCCAGTGGCATC
AATGCACAGAGGGGCCAGCTGTCACCTGAAGGCATGGTCTGGTTTCTCTGTGGGCCAGAGAACAGCGTGCTGGCCCAGGACAAGCTGCTG
CTCCACCACGACATGACGCAGCCACTCAATCATTACTTCATCAACTCGTCCCACAACACCTACCTGACAGCCGGCCAGTTCTCAGGCCTC
TCCTCGGCTGAGATGTACCGCCAGGTGCTGCTCTCTGGCTGCCGTTGCGTGGAGCTAGACTGCTGGAAGGGGAAACCCCCTGACGAGGAG
CCCATTATCACCCATGGCTTCACCATGACCACAGACATCTTCTTCAAAGAAGCAATTGAGGCTATTGCAGAAAGCGCCTTTAAGACCTCC
CCCTATCCCATCATCCTGTCGTTTGAGAACCATGTGGACTCACCCCGCCAGCAGGCTAAGATGGCTGAGTATTGCCGGACGATCTTTGGG
GATATGCTGCTCACAGAGCCCCTGGAAAAGTTCCCACTAAAACCAGGTGTCCCCCTGCCCAGCCCTGAGGATCTCAGGGGCAAGATCCTC
ATCAAGAACAAGAAGAACCAGTTTTCTGGCCCCACCTCCTCCAGTAAGGATACTGGTGGGGAGGCTGAGGGCAGCAGCCCACCCAGTGCC
CCTGCAGGTGAGGGCACAGTGTGGGCTGGCGAGGAAGGGACTGAGCTGGAGGAGGAGGAGGTGGAAGAGGAAGAGGAGGAGGAGTCAGGA
AACCTGGATGAAGAAGAGATTAAGAAGATGCAGTCGGATGAGGGCACAGCGGGCCTGGAAGTGACGGCTTATGAGGAGATGTCCAGCCTA
GTCAATTACATCCAGCCCACCAAGTTCGTCTCCTTTGAGTTCTCTGCCCAAAAGAACCGAAGTTATGTCATCTCGTCCTTCACAGAGCTC
AAGGCATATGACCTGCTCTCCAAGGCCTCGGTGCAGTTTGTGGACTACAACAAGCGCCAGATGAGCCGCATTTACCCCAAGGGAACCCGC
ATGGACTCCTCCAACTACATGCCCCAGATGTTCTGGAATGCTGGATGCCAGATGGTTGCCCTCAACTTCCAGACGATGGACTTGCCCATG
CAGCAGAACATGGCAGTATTTGAGTTCAACGGGCAGAGCGGCTACCTCCTCAAGCATGAGTTCATGCGCCGGCCGGACAAGCAGTTCAAC
CCCTTCTCAGTGGACCGCATCGACGTGGTGGTGGCCACCACCCTTTCCATTACGGTGATCTCTGGGCAGTTCCTGTCAGAACGCAGCGTG
CGCACCTATGTAGAAGTGGAGCTGTTTGGCCTTCCTGGGGACCCCAAGAGGCGCTATCGAACTAAGCTGTCACCCAGTACTAACTCCATC
AATCCTGTCTGGAAGGAGGAGCCCTTTGTCTTTGAGAAGATCTTGATGCCTGAGCTGGCCTCCCTCAGAGTGGCTGTGATGGAGGAAGGC
AACAAGTTTCTTGGACACCGCATCATCCCCATCAATGCCCTAAATTCTGGGTACCACCACCTGTGCCTGCACAGTGAGAGCAACATGCCC
CTCACCATGCCTGCGCTCTTCATCTTCCTGGAGATGAAGGACTACATACCTGGTGCTTGGGCAGATCTCACTGTGGCCCTCGCCAACCCC
ATTAAGTTCTTCAGTGCCCATGACACGAAGTCTGTGAAGCTCAAGGAGGCCATGGGAGGTCTGCCTGAGAAGCCCTTCCCACTGGCGAGT
CCAGTTGCCAGCCAGGTCAATGGGGCGTTGGCCCCAACGAGCAATGGGTCACCAGGAGGCCCAGCCACTGGCCCTTCCGTCACCAACCCC
TTCCAGCCCGCGCCTCCCGCGACGCTCACCCTGAACCAGCTCCGTCTCAGTCCTGTGCCTCCCGTCCCTGGAGCGCCACCCACGTACATC
TCTCCCCTTGGCGGGGGCCCTGGCCTGCCCCCCATGATGCCCCCGGGCCCCCCGGCCCCCAACACTAATCCCTTCCTCCTATAATCCAGG
GCGGAAGGGGGCCTGGCTCCATCCGGCTGCCCCATTCCGGCTCCCTGGGAGATCAGTGTTGTGAGTGCATGTGAAATGGGGGATCCCCAC
CCCCAGTGCCCTTCCCCTTCCTGGGGCCCACTCACACTACACCCTCTTCCTTTCCCACCCCACCTCCCCGGAGAGAAACTGGACATGGGG
CCTGGGGAGGGGAGCTGGCCAGAGGAGGACCCCTTTCCCGTGGCATTAGAAGGGGGAGGGGTGGCTGGGGCCCCCACCCATTCCCCCTCC
CTCCAAACTCCCAACCCCCAGTCAGTGTTTGAGCCTCCTCGTTCCCCTCACGCACCCGCTCACGCACCCTCGGTGAATCCTTGGTGATGA

>65980_65980_3_PLCB2-EPN1_PLCB2_chr15_40584049_ENST00000456256_EPN1_chr19_56206513_ENST00000085079_length(amino acids)=959AA_BP=890
MASFLPFCLPVSAEILQRGTLGTMSLLNPVLLPPKVKAYLSQGERFIKWDDETTVASPVILRVDPKGYYLYWTYQSKEMEFLDITSIRDT
RFGKFAKMPKSQKLRDVFNMDFPDNSFLLKTLTVVSGPDMVDLTFHNFVSYKENVGKAWAEDVLALVKHPLTANASRSTFLDKILVKLKM
QLNSEGKIPVKNFFQMFPADRKRVEAALSACHLPKGKNDAINPEDFPEPVYKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEHLTKFINQ
KQRDSRLNSLLFPPARPDQVQGLIDKYEPSGINAQRGQLSPEGMVWFLCGPENSVLAQDKLLLHHDMTQPLNHYFINSSHNTYLTAGQFS
GLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDIFFKEAIEAIAESAFKTSPYPIILSFENHVDSPRQQAKMAEYCRTI
FGDMLLTEPLEKFPLKPGVPLPSPEDLRGKILIKNKKNQFSGPTSSSKDTGGEAEGSSPPSAPAGEGTVWAGEEGTELEEEEVEEEEEEE
SGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFVSFEFSAQKNRSYVISSFTELKAYDLLSKASVQFVDYNKRQMSRIYPKG
TRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMAVFEFNGQSGYLLKHEFMRRPDKQFNPFSVDRIDVVVATTLSITVISGQFLSER
SVRTYVEVELFGLPGDPKRRYRTKLSPSTNSINPVWKEEPFVFEKILMPELASLRVAVMEEGNKFLGHRIIPINALNSGYHHLCLHSESN
MPLTMPALFIFLEMKDYIPGAWADLTVALANPIKFFSAHDTKSVKLKEAMGGLPEKPFPLASPVASQVNGALAPTSNGSPGGPATGPSVT

--------------------------------------------------------------
>65980_65980_4_PLCB2-EPN1_PLCB2_chr15_40584049_ENST00000456256_EPN1_chr19_56206513_ENST00000270460_length(transcript)=3374nt_BP=2755nt
CCCCAGGGGCTATAAGAGCAACTAGATTTCTGGAGCAGCTCGGGGATGGGTGCCATTTGAGCCCAGCTTGGCTCCCCCTCCTGGCTGGCC
TCCTTCCTGCCCTTCTGCCTGCCTGTGTCTGCTGAGATTCTGCAAAGAGGAACGCTTGGCACCATGTCTCTGCTCAACCCTGTCCTGCTG
CCCCCCAAGGTGAAGGCCTATCTGAGCCAAGGGGAGCGCTTCATCAAATGGGATGATGAAACTACAGTTGCCTCTCCAGTTATCCTCCGT
GTGGATCCTAAGGGCTACTACTTATACTGGACGTATCAAAGTAAGGAGATGGAGTTTCTGGATATCACCAGCATCCGGGATACTCGCTTT
GGGAAGTTTGCCAAGATGCCCAAGAGCCAGAAGCTCCGGGACGTCTTCAACATGGACTTTCCTGATAACAGTTTCCTGCTGAAGACACTC
ACGGTGGTGTCCGGCCCGGACATGGTGGACCTCACCTTCCACAACTTCGTCTCCTACAAGGAGAACGTGGGCAAGGCCTGGGCTGAGGAC
GTACTGGCCCTAGTCAAACATCCGCTGACGGCCAACGCCTCCCGCAGCACCTTCCTGGACAAGATCCTTGTGAAGCTCAAGATGCAGCTC
AACTCTGAAGGGAAGATTCCGGTGAAGAACTTTTTCCAGATGTTTCCTGCTGACCGCAAGCGGGTGGAAGCTGCTCTCAGTGCCTGCCAC
CTCCCCAAAGGCAAAAATGACGCCATCAATCCTGAGGACTTCCCAGAACCTGTCTACAAGAGTTTCCTCATGAGCCTCTGTCCTCGGCCA
GAAATAGATGAGATCTTCACTTCTTACCATGCTAAGGCCAAACCCTACATGACGAAGGAGCACCTGACCAAATTCATCAACCAGAAACAG
CGGGACTCCCGGCTTAACTCCCTGCTGTTCCCGCCAGCACGGCCTGACCAGGTGCAGGGCCTCATCGACAAGTATGAGCCCAGTGGCATC
AATGCACAGAGGGGCCAGCTGTCACCTGAAGGCATGGTCTGGTTTCTCTGTGGGCCAGAGAACAGCGTGCTGGCCCAGGACAAGCTGCTG
CTCCACCACGACATGACGCAGCCACTCAATCATTACTTCATCAACTCGTCCCACAACACCTACCTGACAGCCGGCCAGTTCTCAGGCCTC
TCCTCGGCTGAGATGTACCGCCAGGTGCTGCTCTCTGGCTGCCGTTGCGTGGAGCTAGACTGCTGGAAGGGGAAACCCCCTGACGAGGAG
CCCATTATCACCCATGGCTTCACCATGACCACAGACATCTTCTTCAAAGAAGCAATTGAGGCTATTGCAGAAAGCGCCTTTAAGACCTCC
CCCTATCCCATCATCCTGTCGTTTGAGAACCATGTGGACTCACCCCGCCAGCAGGCTAAGATGGCTGAGTATTGCCGGACGATCTTTGGG
GATATGCTGCTCACAGAGCCCCTGGAAAAGTTCCCACTAAAACCAGGTGTCCCCCTGCCCAGCCCTGAGGATCTCAGGGGCAAGATCCTC
ATCAAGAACAAGAAGAACCAGTTTTCTGGCCCCACCTCCTCCAGTAAGGATACTGGTGGGGAGGCTGAGGGCAGCAGCCCACCCAGTGCC
CCTGCAGGTGAGGGCACAGTGTGGGCTGGCGAGGAAGGGACTGAGCTGGAGGAGGAGGAGGTGGAAGAGGAAGAGGAGGAGGAGTCAGGA
AACCTGGATGAAGAAGAGATTAAGAAGATGCAGTCGGATGAGGGCACAGCGGGCCTGGAAGTGACGGCTTATGAGGAGATGTCCAGCCTA
GTCAATTACATCCAGCCCACCAAGTTCGTCTCCTTTGAGTTCTCTGCCCAAAAGAACCGAAGTTATGTCATCTCGTCCTTCACAGAGCTC
AAGGCATATGACCTGCTCTCCAAGGCCTCGGTGCAGTTTGTGGACTACAACAAGCGCCAGATGAGCCGCATTTACCCCAAGGGAACCCGC
ATGGACTCCTCCAACTACATGCCCCAGATGTTCTGGAATGCTGGATGCCAGATGGTTGCCCTCAACTTCCAGACGATGGACTTGCCCATG
CAGCAGAACATGGCAGTATTTGAGTTCAACGGGCAGAGCGGCTACCTCCTCAAGCATGAGTTCATGCGCCGGCCGGACAAGCAGTTCAAC
CCCTTCTCAGTGGACCGCATCGACGTGGTGGTGGCCACCACCCTTTCCATTACGGTGATCTCTGGGCAGTTCCTGTCAGAACGCAGCGTG
CGCACCTATGTAGAAGTGGAGCTGTTTGGCCTTCCTGGGGACCCCAAGAGGCGCTATCGAACTAAGCTGTCACCCAGTACTAACTCCATC
AATCCTGTCTGGAAGGAGGAGCCCTTTGTCTTTGAGAAGATCTTGATGCCTGAGCTGGCCTCCCTCAGAGTGGCTGTGATGGAGGAAGGC
AACAAGTTTCTTGGACACCGCATCATCCCCATCAATGCCCTAAATTCTGGGTACCACCACCTGTGCCTGCACAGTGAGAGCAACATGCCC
CTCACCATGCCTGCGCTCTTCATCTTCCTGGAGATGAAGGACTACATACCTGGTGCTTGGGCAGATCTCACTGTGGCCCTCGCCAACCCC
ATTAAGTTCTTCAGTGCCCATGACACGAAGTCTGTGAAGCTCAAGGAGGCCATGGGAGGTCTGCCTGAGAAGCCCTTCCCACTGGCGAGT
CCAGTTGCCAGCCAGGTCAATGGGGCGTTGGCCCCAACGAGCAATGGGTCACCAGGAGGCCCAGCCACTGGCCCTTCCGTCACCAACCCC
TTCCAGCCCGCGCCTCCCGCGACGCTCACCCTGAACCAGCTCCGTCTCAGTCCTGTGCCTCCCGTCCCTGGAGCGCCACCCACGTACATC
TCTCCCCTTGGCGGGGGCCCTGGCCTGCCCCCCATGATGCCCCCGGGCCCCCCGGCCCCCAACACTAATCCCTTCCTCCTATAATCCAGG
GCGGAAGGGGGCCTGGCTCCATCCGGCTGCCCCATTCCGGCTCCCTGGGAGATCAGTGTTGTGAGTGCATGTGAAATGGGGGATCCCCAC
CCCCAGTGCCCTTCCCCTTCCTGGGGCCCACTCACACTACACCCTCTTCCTTTCCCACCCCACCTCCCCGGAGAGAAACTGGACATGGGG
CCTGGGGAGGGGAGCTGGCCAGAGGAGGACCCCTTTCCCGTGGCATTAGAAGGGGGAGGGGTGGCTGGGGCCCCCACCCATTCCCCCTCC
CTCCAAACTCCCAACCCCCAGTCAGTGTTTGAGCCTCCTCGTTCCCCTCACGCACCCGCTCACGCACCCTCGGTGAATCCTTGGTGATGA

>65980_65980_4_PLCB2-EPN1_PLCB2_chr15_40584049_ENST00000456256_EPN1_chr19_56206513_ENST00000270460_length(amino acids)=959AA_BP=890
MASFLPFCLPVSAEILQRGTLGTMSLLNPVLLPPKVKAYLSQGERFIKWDDETTVASPVILRVDPKGYYLYWTYQSKEMEFLDITSIRDT
RFGKFAKMPKSQKLRDVFNMDFPDNSFLLKTLTVVSGPDMVDLTFHNFVSYKENVGKAWAEDVLALVKHPLTANASRSTFLDKILVKLKM
QLNSEGKIPVKNFFQMFPADRKRVEAALSACHLPKGKNDAINPEDFPEPVYKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEHLTKFINQ
KQRDSRLNSLLFPPARPDQVQGLIDKYEPSGINAQRGQLSPEGMVWFLCGPENSVLAQDKLLLHHDMTQPLNHYFINSSHNTYLTAGQFS
GLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDIFFKEAIEAIAESAFKTSPYPIILSFENHVDSPRQQAKMAEYCRTI
FGDMLLTEPLEKFPLKPGVPLPSPEDLRGKILIKNKKNQFSGPTSSSKDTGGEAEGSSPPSAPAGEGTVWAGEEGTELEEEEVEEEEEEE
SGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFVSFEFSAQKNRSYVISSFTELKAYDLLSKASVQFVDYNKRQMSRIYPKG
TRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMAVFEFNGQSGYLLKHEFMRRPDKQFNPFSVDRIDVVVATTLSITVISGQFLSER
SVRTYVEVELFGLPGDPKRRYRTKLSPSTNSINPVWKEEPFVFEKILMPELASLRVAVMEEGNKFLGHRIIPINALNSGYHHLCLHSESN
MPLTMPALFIFLEMKDYIPGAWADLTVALANPIKFFSAHDTKSVKLKEAMGGLPEKPFPLASPVASQVNGALAPTSNGSPGGPATGPSVT

--------------------------------------------------------------
>65980_65980_5_PLCB2-EPN1_PLCB2_chr15_40584049_ENST00000557821_EPN1_chr19_56206513_ENST00000085079_length(transcript)=3374nt_BP=2755nt
CAGCCAGGGCCACCCCAGGGGCTATAAGAGCAACTAGATTTCTGGAGCAGCTCGGGGATGGGTGCCATTTGAGCCCAGCTTGGCTCCCCC
TCCTGGCTGGCCTCCTTCCTGCCCTTCTGCCTGCCTGTGTCTGCTGAGATTCTGCAAAGAGGAACGCTTGGCACCATGTCTCTGCTCAAC
CCTGTCCTGCTGCCCCCCAAGGTGAAGGCCTATCTGAGCCAAGGGGAGCGCTTCATCAAATGGGATGATGAAACTACAGTTGCCTCTCCA
GTTATCCTCCGTGTGGATCCTAAGGGCTACTACTTATACTGGACGTATCAAAGTAAGGAGATGGAGTTTCTGGATATCACCAGCATCCGG
GATACTCGCTTTGGGAAGTTTGCCAAGATGCCCAAGAGCCAGAAGCTCCGGGACGTCTTCAACATGGACTTTCCTGATAACAGTTTCCTG
CTGAAGACACTCACGGTGGTGTCCGGCCCGGACATGGTGGACCTCACCTTCCACAACTTCGTCTCCTACAAGGAGAACGTGGGCAAGGCC
TGGGCTGAGGACGTACTGGCCCTAGTCAAACATCCGCTGACGGCCAACGCCTCCCGCAGCACCTTCCTGGACAAGATCCTTGTGAAGCTC
AAGATGCAGCTCAACTCTGAAGGGAAGATTCCGGTGAAGAACTTTTTCCAGATGTTTCCTGCTGACCGCAAGCGGGTGGAAGCTGCTCTC
AGTGCCTGCCACCTCCCCAAAGGCAAAAATGACGCCATCAATCCTGAGGACTTCCCAGAACCTGTCTACAAGAGTTTCCTCATGAGCCTC
TGTCCTCGGCCAGAAATAGATGAGATCTTCACTTCTTACCATGCTAAGGCCAAACCCTACATGACGAAGGAGCACCTGACCAAATTCATC
AACCAGAAACAGCGGGACTCCCGGCTTAACTCCCTGCTGTTCCCGCCAGCACGGCCTGACCAGGTGCAGGGCCTCATCGACAAGTATGAG
CCCAGTGGCATCAATGCACAGAGGGGCCAGCTGTCACCTGAAGGCATGGTCTGGTTTCTCTGTGGGCCAGAGAACAGCGTGCTGGCCCAG
GACAAGCTGCTGCTCCACCACGACATGACGCAGCCACTCAATCATTACTTCATCAACTCGTCCCACAACACCTACCTGACAGCCGGCCAG
TTCTCAGGCCTCTCCTCGGCTGAGATGTACCGCCAGGTGCTGCTCTCTGGCTGCCGTTGCGTGGAGCTAGACTGCTGGAAGGGGAAACCC
CCTGACGAGGAGCCCATTATCACCCATGGCTTCACCATGACCACAGACATCTTCTTCAAAGAAGCAATTGAGGCTATTGCAGAAAGCGCC
TTTAAGACCTCCCCCTATCCCATCATCCTGTCGTTTGAGAACCATGTGGACTCACCCCGCCAGCAGGCTAAGATGGCTGAGTATTGCCGG
ACGATCTTTGGGGATATGCTGCTCACAGAGCCCCTGGAAAAGTTCCCACTAAAACCAGGTGTCCCCCTGCCCAGCCCTGAGGATCTCAGG
GGCAAGATCCTCATCAAGAACAAGAAGAACCAGTTTTCTGGCCCCACCTCCTCCAGTAAGGATACTGGTGGGGAGGCTGAGGGCAGCAGC
CCACCCAGTGCCCCTGCAGTGTGGGCTGGCGAGGAAGGGACTGAGCTGGAGGAGGAGGAGGTGGAAGAGGAAGAGGAGGAGGAGTCAGGA
AACCTGGATGAAGAAGAGATTAAGAAGATGCAGTCGGATGAGGGCACAGCGGGCCTGGAAGTGACGGCTTATGAGGAGATGTCCAGCCTA
GTCAATTACATCCAGCCCACCAAGTTCGTCTCCTTTGAGTTCTCTGCCCAAAAGAACCGAAGTTATGTCATCTCGTCCTTCACAGAGCTC
AAGGCATATGACCTGCTCTCCAAGGCCTCGGTGCAGTTTGTGGACTACAACAAGCGCCAGATGAGCCGCATTTACCCCAAGGGAACCCGC
ATGGACTCCTCCAACTACATGCCCCAGATGTTCTGGAATGCTGGATGCCAGATGGTTGCCCTCAACTTCCAGACGATGGACTTGCCCATG
CAGCAGAACATGGCAGTATTTGAGTTCAACGGGCAGAGCGGCTACCTCCTCAAGCATGAGTTCATGCGCCGGCCGGACAAGCAGTTCAAC
CCCTTCTCAGTGGACCGCATCGACGTGGTGGTGGCCACCACCCTTTCCATTACGGTGATCTCTGGGCAGTTCCTGTCAGAACGCAGCGTG
CGCACCTATGTAGAAGTGGAGCTGTTTGGCCTTCCTGGGGACCCCAAGAGGCGCTATCGAACTAAGCTGTCACCCAGTACTAACTCCATC
AATCCTGTCTGGAAGGAGGAGCCCTTTGTCTTTGAGAAGATCTTGATGCCTGAGCTGGCCTCCCTCAGAGTGGCTGTGATGGAGGAAGGC
AACAAGTTTCTTGGACACCGCATCATCCCCATCAATGCCCTAAATTCTGGGTACCACCACCTGTGCCTGCACAGTGAGAGCAACATGCCC
CTCACCATGCCTGCGCTCTTCATCTTCCTGGAGATGAAGGACTACATACCTGGTGCTTGGGCAGATCTCACTGTGGCCCTCGCCAACCCC
ATTAAGTTCTTCAGTGCCCATGACACGAAGTCTGTGAAGCTCAAGGAGGCCATGGGAGGTCTGCCTGAGAAGCCCTTCCCACTGGCGAGT
CCAGTTGCCAGCCAGGTCAATGGGGCGTTGGCCCCAACGAGCAATGGGTCACCAGGAGGCCCAGCCACTGGCCCTTCCGTCACCAACCCC
TTCCAGCCCGCGCCTCCCGCGACGCTCACCCTGAACCAGCTCCGTCTCAGTCCTGTGCCTCCCGTCCCTGGAGCGCCACCCACGTACATC
TCTCCCCTTGGCGGGGGCCCTGGCCTGCCCCCCATGATGCCCCCGGGCCCCCCGGCCCCCAACACTAATCCCTTCCTCCTATAATCCAGG
GCGGAAGGGGGCCTGGCTCCATCCGGCTGCCCCATTCCGGCTCCCTGGGAGATCAGTGTTGTGAGTGCATGTGAAATGGGGGATCCCCAC
CCCCAGTGCCCTTCCCCTTCCTGGGGCCCACTCACACTACACCCTCTTCCTTTCCCACCCCACCTCCCCGGAGAGAAACTGGACATGGGG
CCTGGGGAGGGGAGCTGGCCAGAGGAGGACCCCTTTCCCGTGGCATTAGAAGGGGGAGGGGTGGCTGGGGCCCCCACCCATTCCCCCTCC
CTCCAAACTCCCAACCCCCAGTCAGTGTTTGAGCCTCCTCGTTCCCCTCACGCACCCGCTCACGCACCCTCGGTGAATCCTTGGTGATGA

>65980_65980_5_PLCB2-EPN1_PLCB2_chr15_40584049_ENST00000557821_EPN1_chr19_56206513_ENST00000085079_length(amino acids)=955AA_BP=886
MASFLPFCLPVSAEILQRGTLGTMSLLNPVLLPPKVKAYLSQGERFIKWDDETTVASPVILRVDPKGYYLYWTYQSKEMEFLDITSIRDT
RFGKFAKMPKSQKLRDVFNMDFPDNSFLLKTLTVVSGPDMVDLTFHNFVSYKENVGKAWAEDVLALVKHPLTANASRSTFLDKILVKLKM
QLNSEGKIPVKNFFQMFPADRKRVEAALSACHLPKGKNDAINPEDFPEPVYKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEHLTKFINQ
KQRDSRLNSLLFPPARPDQVQGLIDKYEPSGINAQRGQLSPEGMVWFLCGPENSVLAQDKLLLHHDMTQPLNHYFINSSHNTYLTAGQFS
GLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDIFFKEAIEAIAESAFKTSPYPIILSFENHVDSPRQQAKMAEYCRTI
FGDMLLTEPLEKFPLKPGVPLPSPEDLRGKILIKNKKNQFSGPTSSSKDTGGEAEGSSPPSAPAVWAGEEGTELEEEEVEEEEEEESGNL
DEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFVSFEFSAQKNRSYVISSFTELKAYDLLSKASVQFVDYNKRQMSRIYPKGTRMD
SSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMAVFEFNGQSGYLLKHEFMRRPDKQFNPFSVDRIDVVVATTLSITVISGQFLSERSVRT
YVEVELFGLPGDPKRRYRTKLSPSTNSINPVWKEEPFVFEKILMPELASLRVAVMEEGNKFLGHRIIPINALNSGYHHLCLHSESNMPLT
MPALFIFLEMKDYIPGAWADLTVALANPIKFFSAHDTKSVKLKEAMGGLPEKPFPLASPVASQVNGALAPTSNGSPGGPATGPSVTNPFQ

--------------------------------------------------------------
>65980_65980_6_PLCB2-EPN1_PLCB2_chr15_40584049_ENST00000557821_EPN1_chr19_56206513_ENST00000270460_length(transcript)=3374nt_BP=2755nt
CAGCCAGGGCCACCCCAGGGGCTATAAGAGCAACTAGATTTCTGGAGCAGCTCGGGGATGGGTGCCATTTGAGCCCAGCTTGGCTCCCCC
TCCTGGCTGGCCTCCTTCCTGCCCTTCTGCCTGCCTGTGTCTGCTGAGATTCTGCAAAGAGGAACGCTTGGCACCATGTCTCTGCTCAAC
CCTGTCCTGCTGCCCCCCAAGGTGAAGGCCTATCTGAGCCAAGGGGAGCGCTTCATCAAATGGGATGATGAAACTACAGTTGCCTCTCCA
GTTATCCTCCGTGTGGATCCTAAGGGCTACTACTTATACTGGACGTATCAAAGTAAGGAGATGGAGTTTCTGGATATCACCAGCATCCGG
GATACTCGCTTTGGGAAGTTTGCCAAGATGCCCAAGAGCCAGAAGCTCCGGGACGTCTTCAACATGGACTTTCCTGATAACAGTTTCCTG
CTGAAGACACTCACGGTGGTGTCCGGCCCGGACATGGTGGACCTCACCTTCCACAACTTCGTCTCCTACAAGGAGAACGTGGGCAAGGCC
TGGGCTGAGGACGTACTGGCCCTAGTCAAACATCCGCTGACGGCCAACGCCTCCCGCAGCACCTTCCTGGACAAGATCCTTGTGAAGCTC
AAGATGCAGCTCAACTCTGAAGGGAAGATTCCGGTGAAGAACTTTTTCCAGATGTTTCCTGCTGACCGCAAGCGGGTGGAAGCTGCTCTC
AGTGCCTGCCACCTCCCCAAAGGCAAAAATGACGCCATCAATCCTGAGGACTTCCCAGAACCTGTCTACAAGAGTTTCCTCATGAGCCTC
TGTCCTCGGCCAGAAATAGATGAGATCTTCACTTCTTACCATGCTAAGGCCAAACCCTACATGACGAAGGAGCACCTGACCAAATTCATC
AACCAGAAACAGCGGGACTCCCGGCTTAACTCCCTGCTGTTCCCGCCAGCACGGCCTGACCAGGTGCAGGGCCTCATCGACAAGTATGAG
CCCAGTGGCATCAATGCACAGAGGGGCCAGCTGTCACCTGAAGGCATGGTCTGGTTTCTCTGTGGGCCAGAGAACAGCGTGCTGGCCCAG
GACAAGCTGCTGCTCCACCACGACATGACGCAGCCACTCAATCATTACTTCATCAACTCGTCCCACAACACCTACCTGACAGCCGGCCAG
TTCTCAGGCCTCTCCTCGGCTGAGATGTACCGCCAGGTGCTGCTCTCTGGCTGCCGTTGCGTGGAGCTAGACTGCTGGAAGGGGAAACCC
CCTGACGAGGAGCCCATTATCACCCATGGCTTCACCATGACCACAGACATCTTCTTCAAAGAAGCAATTGAGGCTATTGCAGAAAGCGCC
TTTAAGACCTCCCCCTATCCCATCATCCTGTCGTTTGAGAACCATGTGGACTCACCCCGCCAGCAGGCTAAGATGGCTGAGTATTGCCGG
ACGATCTTTGGGGATATGCTGCTCACAGAGCCCCTGGAAAAGTTCCCACTAAAACCAGGTGTCCCCCTGCCCAGCCCTGAGGATCTCAGG
GGCAAGATCCTCATCAAGAACAAGAAGAACCAGTTTTCTGGCCCCACCTCCTCCAGTAAGGATACTGGTGGGGAGGCTGAGGGCAGCAGC
CCACCCAGTGCCCCTGCAGTGTGGGCTGGCGAGGAAGGGACTGAGCTGGAGGAGGAGGAGGTGGAAGAGGAAGAGGAGGAGGAGTCAGGA
AACCTGGATGAAGAAGAGATTAAGAAGATGCAGTCGGATGAGGGCACAGCGGGCCTGGAAGTGACGGCTTATGAGGAGATGTCCAGCCTA
GTCAATTACATCCAGCCCACCAAGTTCGTCTCCTTTGAGTTCTCTGCCCAAAAGAACCGAAGTTATGTCATCTCGTCCTTCACAGAGCTC
AAGGCATATGACCTGCTCTCCAAGGCCTCGGTGCAGTTTGTGGACTACAACAAGCGCCAGATGAGCCGCATTTACCCCAAGGGAACCCGC
ATGGACTCCTCCAACTACATGCCCCAGATGTTCTGGAATGCTGGATGCCAGATGGTTGCCCTCAACTTCCAGACGATGGACTTGCCCATG
CAGCAGAACATGGCAGTATTTGAGTTCAACGGGCAGAGCGGCTACCTCCTCAAGCATGAGTTCATGCGCCGGCCGGACAAGCAGTTCAAC
CCCTTCTCAGTGGACCGCATCGACGTGGTGGTGGCCACCACCCTTTCCATTACGGTGATCTCTGGGCAGTTCCTGTCAGAACGCAGCGTG
CGCACCTATGTAGAAGTGGAGCTGTTTGGCCTTCCTGGGGACCCCAAGAGGCGCTATCGAACTAAGCTGTCACCCAGTACTAACTCCATC
AATCCTGTCTGGAAGGAGGAGCCCTTTGTCTTTGAGAAGATCTTGATGCCTGAGCTGGCCTCCCTCAGAGTGGCTGTGATGGAGGAAGGC
AACAAGTTTCTTGGACACCGCATCATCCCCATCAATGCCCTAAATTCTGGGTACCACCACCTGTGCCTGCACAGTGAGAGCAACATGCCC
CTCACCATGCCTGCGCTCTTCATCTTCCTGGAGATGAAGGACTACATACCTGGTGCTTGGGCAGATCTCACTGTGGCCCTCGCCAACCCC
ATTAAGTTCTTCAGTGCCCATGACACGAAGTCTGTGAAGCTCAAGGAGGCCATGGGAGGTCTGCCTGAGAAGCCCTTCCCACTGGCGAGT
CCAGTTGCCAGCCAGGTCAATGGGGCGTTGGCCCCAACGAGCAATGGGTCACCAGGAGGCCCAGCCACTGGCCCTTCCGTCACCAACCCC
TTCCAGCCCGCGCCTCCCGCGACGCTCACCCTGAACCAGCTCCGTCTCAGTCCTGTGCCTCCCGTCCCTGGAGCGCCACCCACGTACATC
TCTCCCCTTGGCGGGGGCCCTGGCCTGCCCCCCATGATGCCCCCGGGCCCCCCGGCCCCCAACACTAATCCCTTCCTCCTATAATCCAGG
GCGGAAGGGGGCCTGGCTCCATCCGGCTGCCCCATTCCGGCTCCCTGGGAGATCAGTGTTGTGAGTGCATGTGAAATGGGGGATCCCCAC
CCCCAGTGCCCTTCCCCTTCCTGGGGCCCACTCACACTACACCCTCTTCCTTTCCCACCCCACCTCCCCGGAGAGAAACTGGACATGGGG
CCTGGGGAGGGGAGCTGGCCAGAGGAGGACCCCTTTCCCGTGGCATTAGAAGGGGGAGGGGTGGCTGGGGCCCCCACCCATTCCCCCTCC
CTCCAAACTCCCAACCCCCAGTCAGTGTTTGAGCCTCCTCGTTCCCCTCACGCACCCGCTCACGCACCCTCGGTGAATCCTTGGTGATGA

>65980_65980_6_PLCB2-EPN1_PLCB2_chr15_40584049_ENST00000557821_EPN1_chr19_56206513_ENST00000270460_length(amino acids)=955AA_BP=886
MASFLPFCLPVSAEILQRGTLGTMSLLNPVLLPPKVKAYLSQGERFIKWDDETTVASPVILRVDPKGYYLYWTYQSKEMEFLDITSIRDT
RFGKFAKMPKSQKLRDVFNMDFPDNSFLLKTLTVVSGPDMVDLTFHNFVSYKENVGKAWAEDVLALVKHPLTANASRSTFLDKILVKLKM
QLNSEGKIPVKNFFQMFPADRKRVEAALSACHLPKGKNDAINPEDFPEPVYKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEHLTKFINQ
KQRDSRLNSLLFPPARPDQVQGLIDKYEPSGINAQRGQLSPEGMVWFLCGPENSVLAQDKLLLHHDMTQPLNHYFINSSHNTYLTAGQFS
GLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDIFFKEAIEAIAESAFKTSPYPIILSFENHVDSPRQQAKMAEYCRTI
FGDMLLTEPLEKFPLKPGVPLPSPEDLRGKILIKNKKNQFSGPTSSSKDTGGEAEGSSPPSAPAVWAGEEGTELEEEEVEEEEEEESGNL
DEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFVSFEFSAQKNRSYVISSFTELKAYDLLSKASVQFVDYNKRQMSRIYPKGTRMD
SSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMAVFEFNGQSGYLLKHEFMRRPDKQFNPFSVDRIDVVVATTLSITVISGQFLSERSVRT
YVEVELFGLPGDPKRRYRTKLSPSTNSINPVWKEEPFVFEKILMPELASLRVAVMEEGNKFLGHRIIPINALNSGYHHLCLHSESNMPLT
MPALFIFLEMKDYIPGAWADLTVALANPIKFFSAHDTKSVKLKEAMGGLPEKPFPLASPVASQVNGALAPTSNGSPGGPATGPSVTNPFQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PLCB2-EPN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PLCB2-EPN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PLCB2-EPN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource