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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PLCG1-EYA2 (FusionGDB2 ID:66023)

Fusion Gene Summary for PLCG1-EYA2

check button Fusion gene summary
Fusion gene informationFusion gene name: PLCG1-EYA2
Fusion gene ID: 66023
HgeneTgene
Gene symbol

PLCG1

EYA2

Gene ID

5335

2139

Gene namephospholipase C gamma 1EYA transcriptional coactivator and phosphatase 2
SynonymsNCKAP3|PLC-II|PLC1|PLC148|PLCgamma1EAB1
Cytomap

20q12

20q13.12

Type of geneprotein-codingprotein-coding
Description1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-11-phosphatidyl-D-myo-inositol-4,5-bisphosphatePLC-148PLC-gamma-1inositoltrisphosphohydrolasemonophosphatidylinositol phosphodiesterasephosphatidylinositol phospholipase Cphosphoinositeyes absent homolog 2
Modification date2020031320200313
UniProtAcc.

O00167

Ensembl transtripts involved in fusion geneENST00000244007, ENST00000373271, 
ENST00000373272, ENST00000608689, 
ENST00000317304, ENST00000497428, 
ENST00000327619, ENST00000357410, 
Fusion gene scores* DoF score6 X 5 X 3=9015 X 15 X 10=2250
# samples 730
** MAII scorelog2(7/90*10)=-0.362570079384708
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(30/2250*10)=-2.90689059560852
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PLCG1 [Title/Abstract] AND EYA2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPLCG1(39798909)-EYA2(45797787), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePLCG1

GO:0043536

positive regulation of blood vessel endothelial cell migration

20011604

HgenePLCG1

GO:0045766

positive regulation of angiogenesis

20011604

HgenePLCG1

GO:0071364

cellular response to epidermal growth factor stimulus

17229814

TgeneEYA2

GO:0016576

histone dephosphorylation

19351884


check buttonFusion gene breakpoints across PLCG1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across EYA2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-VQ-A8PH-01APLCG1chr20

39798909

-EYA2chr20

45797787

+
ChimerDB4STADTCGA-VQ-A8PH-01APLCG1chr20

39798909

+EYA2chr20

45797787

+
ChimerDB4STADTCGA-VQ-A8PHPLCG1chr20

39798909

+EYA2chr20

45797786

+


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Fusion Gene ORF analysis for PLCG1-EYA2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000244007ENST00000317304PLCG1chr20

39798909

+EYA2chr20

45797787

+
5CDS-intronENST00000244007ENST00000317304PLCG1chr20

39798909

+EYA2chr20

45797786

+
5CDS-intronENST00000244007ENST00000497428PLCG1chr20

39798909

+EYA2chr20

45797787

+
5CDS-intronENST00000244007ENST00000497428PLCG1chr20

39798909

+EYA2chr20

45797786

+
5CDS-intronENST00000373271ENST00000317304PLCG1chr20

39798909

+EYA2chr20

45797787

+
5CDS-intronENST00000373271ENST00000317304PLCG1chr20

39798909

+EYA2chr20

45797786

+
5CDS-intronENST00000373271ENST00000497428PLCG1chr20

39798909

+EYA2chr20

45797787

+
5CDS-intronENST00000373271ENST00000497428PLCG1chr20

39798909

+EYA2chr20

45797786

+
5CDS-intronENST00000373272ENST00000317304PLCG1chr20

39798909

+EYA2chr20

45797787

+
5CDS-intronENST00000373272ENST00000317304PLCG1chr20

39798909

+EYA2chr20

45797786

+
5CDS-intronENST00000373272ENST00000497428PLCG1chr20

39798909

+EYA2chr20

45797787

+
5CDS-intronENST00000373272ENST00000497428PLCG1chr20

39798909

+EYA2chr20

45797786

+
In-frameENST00000244007ENST00000327619PLCG1chr20

39798909

+EYA2chr20

45797787

+
In-frameENST00000244007ENST00000327619PLCG1chr20

39798909

+EYA2chr20

45797786

+
In-frameENST00000244007ENST00000357410PLCG1chr20

39798909

+EYA2chr20

45797787

+
In-frameENST00000244007ENST00000357410PLCG1chr20

39798909

+EYA2chr20

45797786

+
In-frameENST00000373271ENST00000327619PLCG1chr20

39798909

+EYA2chr20

45797787

+
In-frameENST00000373271ENST00000327619PLCG1chr20

39798909

+EYA2chr20

45797786

+
In-frameENST00000373271ENST00000357410PLCG1chr20

39798909

+EYA2chr20

45797787

+
In-frameENST00000373271ENST00000357410PLCG1chr20

39798909

+EYA2chr20

45797786

+
In-frameENST00000373272ENST00000327619PLCG1chr20

39798909

+EYA2chr20

45797787

+
In-frameENST00000373272ENST00000327619PLCG1chr20

39798909

+EYA2chr20

45797786

+
In-frameENST00000373272ENST00000357410PLCG1chr20

39798909

+EYA2chr20

45797787

+
In-frameENST00000373272ENST00000357410PLCG1chr20

39798909

+EYA2chr20

45797786

+
intron-3CDSENST00000608689ENST00000327619PLCG1chr20

39798909

+EYA2chr20

45797787

+
intron-3CDSENST00000608689ENST00000327619PLCG1chr20

39798909

+EYA2chr20

45797786

+
intron-3CDSENST00000608689ENST00000357410PLCG1chr20

39798909

+EYA2chr20

45797787

+
intron-3CDSENST00000608689ENST00000357410PLCG1chr20

39798909

+EYA2chr20

45797786

+
intron-intronENST00000608689ENST00000317304PLCG1chr20

39798909

+EYA2chr20

45797787

+
intron-intronENST00000608689ENST00000317304PLCG1chr20

39798909

+EYA2chr20

45797786

+
intron-intronENST00000608689ENST00000497428PLCG1chr20

39798909

+EYA2chr20

45797787

+
intron-intronENST00000608689ENST00000497428PLCG1chr20

39798909

+EYA2chr20

45797786

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000244007PLCG1chr2039798909+ENST00000357410EYA2chr2045797787+4118300516134061081
ENST00000244007PLCG1chr2039798909+ENST00000327619EYA2chr2045797787+4355300516136431160
ENST00000373272PLCG1chr2039798909+ENST00000357410EYA2chr2045797787+432632135436141186
ENST00000373272PLCG1chr2039798909+ENST00000327619EYA2chr2045797787+456332135438511265
ENST00000373271PLCG1chr2039798909+ENST00000357410EYA2chr2045797787+432632135436141186
ENST00000373271PLCG1chr2039798909+ENST00000327619EYA2chr2045797787+456332135438511265
ENST00000244007PLCG1chr2039798909+ENST00000357410EYA2chr2045797786+4118300516134061081
ENST00000244007PLCG1chr2039798909+ENST00000327619EYA2chr2045797786+4355300516136431160
ENST00000373272PLCG1chr2039798909+ENST00000357410EYA2chr2045797786+432632135436141186
ENST00000373272PLCG1chr2039798909+ENST00000327619EYA2chr2045797786+456332135438511265
ENST00000373271PLCG1chr2039798909+ENST00000357410EYA2chr2045797786+432632135436141186
ENST00000373271PLCG1chr2039798909+ENST00000327619EYA2chr2045797786+456332135438511265

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000244007ENST00000357410PLCG1chr2039798909+EYA2chr2045797787+0.0026033780.9973966
ENST00000244007ENST00000327619PLCG1chr2039798909+EYA2chr2045797787+0.0016568620.9983431
ENST00000373272ENST00000357410PLCG1chr2039798909+EYA2chr2045797787+0.0028983150.9971016
ENST00000373272ENST00000327619PLCG1chr2039798909+EYA2chr2045797787+0.0018470370.9981529
ENST00000373271ENST00000357410PLCG1chr2039798909+EYA2chr2045797787+0.0028983150.9971016
ENST00000373271ENST00000327619PLCG1chr2039798909+EYA2chr2045797787+0.0018470370.9981529
ENST00000244007ENST00000357410PLCG1chr2039798909+EYA2chr2045797786+0.0026033780.9973966
ENST00000244007ENST00000327619PLCG1chr2039798909+EYA2chr2045797786+0.0016568620.9983431
ENST00000373272ENST00000357410PLCG1chr2039798909+EYA2chr2045797786+0.0028983150.9971016
ENST00000373272ENST00000327619PLCG1chr2039798909+EYA2chr2045797786+0.0018470370.9981529
ENST00000373271ENST00000357410PLCG1chr2039798909+EYA2chr2045797786+0.0028983150.9971016
ENST00000373271ENST00000327619PLCG1chr2039798909+EYA2chr2045797786+0.0018470370.9981529

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Fusion Genomic Features for PLCG1-EYA2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PLCG1chr2039798909+EYA2chr2045797786+8.78E-091
PLCG1chr2039798909+EYA2chr2045797786+8.78E-091
PLCG1chr2039798909+EYA2chr2045797786+8.78E-091
PLCG1chr2039798909+EYA2chr2045797786+8.78E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PLCG1-EYA2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:39798909/chr20:45797787)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.EYA2

O00167

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5 (PubMed:12500905, PubMed:23435380). Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19351884). Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2; in this it is functionally redundant with EYA1 (PubMed:12500905). {ECO:0000269|PubMed:12500905, ECO:0000269|PubMed:19351884, ECO:0000269|PubMed:21706047, ECO:0000269|PubMed:23435380}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePLCG1chr20:39798909chr20:45797786ENST00000244007+2533165_1769361292.0Calcium bindingOntology_term=ECO:0000255
HgenePLCG1chr20:39798909chr20:45797786ENST00000373271+2432165_1769361291.0Calcium bindingOntology_term=ECO:0000255
HgenePLCG1chr20:39798909chr20:45797786ENST00000373272+2432165_1769361292.0Calcium bindingOntology_term=ECO:0000255
HgenePLCG1chr20:39798909chr20:45797787ENST00000244007+2533165_1769361292.0Calcium bindingOntology_term=ECO:0000255
HgenePLCG1chr20:39798909chr20:45797787ENST00000373271+2432165_1769361291.0Calcium bindingOntology_term=ECO:0000255
HgenePLCG1chr20:39798909chr20:45797787ENST00000373272+2432165_1769361292.0Calcium bindingOntology_term=ECO:0000255
HgenePLCG1chr20:39798909chr20:45797786ENST00000244007+2533152_1879361292.0DomainEF-hand
HgenePLCG1chr20:39798909chr20:45797786ENST00000244007+253327_1429361292.0DomainPH 1
HgenePLCG1chr20:39798909chr20:45797786ENST00000244007+2533320_4649361292.0DomainPI-PLC X-box
HgenePLCG1chr20:39798909chr20:45797786ENST00000244007+2533489_5239361292.0DomainPH 2%3B first part
HgenePLCG1chr20:39798909chr20:45797786ENST00000244007+2533550_6579361292.0DomainSH2 1
HgenePLCG1chr20:39798909chr20:45797786ENST00000244007+2533668_7569361292.0DomainSH2 2
HgenePLCG1chr20:39798909chr20:45797786ENST00000244007+2533791_8519361292.0DomainSH3
HgenePLCG1chr20:39798909chr20:45797786ENST00000244007+2533895_9319361292.0DomainPH 2%3B second part
HgenePLCG1chr20:39798909chr20:45797786ENST00000373271+2432152_1879361291.0DomainEF-hand
HgenePLCG1chr20:39798909chr20:45797786ENST00000373271+243227_1429361291.0DomainPH 1
HgenePLCG1chr20:39798909chr20:45797786ENST00000373271+2432320_4649361291.0DomainPI-PLC X-box
HgenePLCG1chr20:39798909chr20:45797786ENST00000373271+2432489_5239361291.0DomainPH 2%3B first part
HgenePLCG1chr20:39798909chr20:45797786ENST00000373271+2432550_6579361291.0DomainSH2 1
HgenePLCG1chr20:39798909chr20:45797786ENST00000373271+2432668_7569361291.0DomainSH2 2
HgenePLCG1chr20:39798909chr20:45797786ENST00000373271+2432791_8519361291.0DomainSH3
HgenePLCG1chr20:39798909chr20:45797786ENST00000373271+2432895_9319361291.0DomainPH 2%3B second part
HgenePLCG1chr20:39798909chr20:45797786ENST00000373272+2432152_1879361292.0DomainEF-hand
HgenePLCG1chr20:39798909chr20:45797786ENST00000373272+243227_1429361292.0DomainPH 1
HgenePLCG1chr20:39798909chr20:45797786ENST00000373272+2432320_4649361292.0DomainPI-PLC X-box
HgenePLCG1chr20:39798909chr20:45797786ENST00000373272+2432489_5239361292.0DomainPH 2%3B first part
HgenePLCG1chr20:39798909chr20:45797786ENST00000373272+2432550_6579361292.0DomainSH2 1
HgenePLCG1chr20:39798909chr20:45797786ENST00000373272+2432668_7569361292.0DomainSH2 2
HgenePLCG1chr20:39798909chr20:45797786ENST00000373272+2432791_8519361292.0DomainSH3
HgenePLCG1chr20:39798909chr20:45797786ENST00000373272+2432895_9319361292.0DomainPH 2%3B second part
HgenePLCG1chr20:39798909chr20:45797787ENST00000244007+2533152_1879361292.0DomainEF-hand
HgenePLCG1chr20:39798909chr20:45797787ENST00000244007+253327_1429361292.0DomainPH 1
HgenePLCG1chr20:39798909chr20:45797787ENST00000244007+2533320_4649361292.0DomainPI-PLC X-box
HgenePLCG1chr20:39798909chr20:45797787ENST00000244007+2533489_5239361292.0DomainPH 2%3B first part
HgenePLCG1chr20:39798909chr20:45797787ENST00000244007+2533550_6579361292.0DomainSH2 1
HgenePLCG1chr20:39798909chr20:45797787ENST00000244007+2533668_7569361292.0DomainSH2 2
HgenePLCG1chr20:39798909chr20:45797787ENST00000244007+2533791_8519361292.0DomainSH3
HgenePLCG1chr20:39798909chr20:45797787ENST00000244007+2533895_9319361292.0DomainPH 2%3B second part
HgenePLCG1chr20:39798909chr20:45797787ENST00000373271+2432152_1879361291.0DomainEF-hand
HgenePLCG1chr20:39798909chr20:45797787ENST00000373271+243227_1429361291.0DomainPH 1
HgenePLCG1chr20:39798909chr20:45797787ENST00000373271+2432320_4649361291.0DomainPI-PLC X-box
HgenePLCG1chr20:39798909chr20:45797787ENST00000373271+2432489_5239361291.0DomainPH 2%3B first part
HgenePLCG1chr20:39798909chr20:45797787ENST00000373271+2432550_6579361291.0DomainSH2 1
HgenePLCG1chr20:39798909chr20:45797787ENST00000373271+2432668_7569361291.0DomainSH2 2
HgenePLCG1chr20:39798909chr20:45797787ENST00000373271+2432791_8519361291.0DomainSH3
HgenePLCG1chr20:39798909chr20:45797787ENST00000373271+2432895_9319361291.0DomainPH 2%3B second part
HgenePLCG1chr20:39798909chr20:45797787ENST00000373272+2432152_1879361292.0DomainEF-hand
HgenePLCG1chr20:39798909chr20:45797787ENST00000373272+243227_1429361292.0DomainPH 1
HgenePLCG1chr20:39798909chr20:45797787ENST00000373272+2432320_4649361292.0DomainPI-PLC X-box
HgenePLCG1chr20:39798909chr20:45797787ENST00000373272+2432489_5239361292.0DomainPH 2%3B first part
HgenePLCG1chr20:39798909chr20:45797787ENST00000373272+2432550_6579361292.0DomainSH2 1
HgenePLCG1chr20:39798909chr20:45797787ENST00000373272+2432668_7569361292.0DomainSH2 2
HgenePLCG1chr20:39798909chr20:45797787ENST00000373272+2432791_8519361292.0DomainSH3
HgenePLCG1chr20:39798909chr20:45797787ENST00000373272+2432895_9319361292.0DomainPH 2%3B second part

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePLCG1chr20:39798909chr20:45797786ENST00000244007+25331071_11949361292.0DomainC2
HgenePLCG1chr20:39798909chr20:45797786ENST00000244007+2533953_10709361292.0DomainPI-PLC Y-box
HgenePLCG1chr20:39798909chr20:45797786ENST00000373271+24321071_11949361291.0DomainC2
HgenePLCG1chr20:39798909chr20:45797786ENST00000373271+2432953_10709361291.0DomainPI-PLC Y-box
HgenePLCG1chr20:39798909chr20:45797786ENST00000373272+24321071_11949361292.0DomainC2
HgenePLCG1chr20:39798909chr20:45797786ENST00000373272+2432953_10709361292.0DomainPI-PLC Y-box
HgenePLCG1chr20:39798909chr20:45797787ENST00000244007+25331071_11949361292.0DomainC2
HgenePLCG1chr20:39798909chr20:45797787ENST00000244007+2533953_10709361292.0DomainPI-PLC Y-box
HgenePLCG1chr20:39798909chr20:45797787ENST00000373271+24321071_11949361291.0DomainC2
HgenePLCG1chr20:39798909chr20:45797787ENST00000373271+2432953_10709361291.0DomainPI-PLC Y-box
HgenePLCG1chr20:39798909chr20:45797787ENST00000373272+24321071_11949361292.0DomainC2
HgenePLCG1chr20:39798909chr20:45797787ENST00000373272+2432953_10709361292.0DomainPI-PLC Y-box


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Fusion Gene Sequence for PLCG1-EYA2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>66023_66023_1_PLCG1-EYA2_PLCG1_chr20_39798909_ENST00000244007_EYA2_chr20_45797786_ENST00000327619_length(transcript)=4355nt_BP=3005nt
GAGGGCGCGCGGAGGACCCGCCGCCGCCGGTGTGAGGCGGCCCGTCCTGGCTCCCTTGTCCGGGAAGCCCGCCCAGGAGCCGCCGCCGGG
TCCCGCTCGTCTGCCGCCTCAGCCTCAGCCCCAACCTCAGCCGCCGCCGTTGCGCTTGCTCCCGGGCGGTCCTGGCCTGTGCCGCCGCCG
CCCCCAGCGTCGGAGCCATGGCGGGCGCCGCGTCCCCTTGCGCCAACGGCTGCGGGCCCGGCGCGCCCTCGGACGCCGAGGTGCTGCACC
TCTGCCGCAGCCTCGAGGTGGGCACCGTCATGACTTTGTTCTACTCCAAGAAGTCGCAGCGACCCGAGCGGAAGACCTTCCAGGTCAAGC
TGGAGACGCGCCAGATCACGTGGAGCCGGGGCGCCGACAAGATCGAGGGGGCCATTGACATTCGTGAAATTAAGGAGATCCGCCCAGGGA
AGACCTCACGGGACTTTGATCGCTATCAAGAGGACCCAGCTTTCCGGCCGGACCAGTCACATTGCTTTGTCATTCTCTATGGAATGGAAT
TTCGCCTGAAAACGCTGAGCCTGCAAGCCACATCTGAGGATGAAGTGAACATGTGGATCAAGGGCTTAACTTGGCTGATGGAGGATACAT
TGCAGGCACCCACACCCCTGCAGATTGAGAGGTGGCTCCGGAAGCAGTTTTACTCAGTGGATCGGAATCGTGAGGATCGTATATCAGCCA
AGGACCTGAAGAACATGCTGTCCCAGGTCAACTACCGGGTCCCCAACATGCGCTTCCTCCGAGAGCGGCTGACGGACCTGGAGCAGCGCA
GCGGGGACATCACCTACGGGCAGTTTGCTCAGCTGTACCGCAGCCTCATGTACAGCGCCCAGAAGACGATGGACCTCCCCTTCTTGGAAG
CCAGTACTCTGAGGGCTGGGGAGCGGCCGGAGCTTTGCCGAGTGTCCCTTCCTGAGTTCCAGCAGTTCCTTCTTGACTACCAGGGGGAGC
TGTGGGCTGTTGATCGCCTCCAGGTGCAGGAGTTCATGCTCAGCTTCCTCCGAGACCCCTTACGAGAGATCGAGGAGCCATACTTCTTCC
TGGATGAGTTTGTCACCTTCCTGTTCTCCAAAGAGAACAGTGTGTGGAACTCGCAGCTGGATGCAGTATGCCCGGACACCATGAACAACC
CTCTTTCCCACTACTGGATCTCCTCCTCGCACAACACGTACCTGACCGGGGACCAGTTCTCCAGTGAGTCCTCCTTGGAAGCCTATGCTC
GCTGCCTGCGGATGGGCTGTCGCTGCATTGAGTTGGACTGCTGGGACGGCCCGGATGGGATGCCAGTTATTTACCATGGGCACACCCTTA
CCACCAAGATCAAGTTCTCAGATGTCCTGCACACCATCAAGGAGCATGCCTTTGTGGCCTCAGAGTACCCAGTCATCCTGTCCATTGAGG
ACCACTGCAGCATTGCCCAGCAGAGAAACATGGCCCAATACTTCAAGAAGGTGCTGGGGGACACACTCCTCACCAAGCCCGTGGAGATCT
CTGCCGACGGGCTCCCCTCACCCAACCAGCTTAAGAGGAAGATCCTCATCAAGCACAAGAAGCTGGCTGAGGGCAGTGCCTACGAGGAGG
TGCCTACATCCATGATGTACTCTGAGAACGACATCAGCAACTCTATCAAGAATGGCATCCTCTACCTGGAGGACCCTGTGAACCACGAAT
GGTATCCCCACTACTTTGTTCTGACCAGCAGCAAGATCTACTACTCTGAGGAGACCAGCAGTGACCAGGGCAACGAGGATGAGGAGGAGC
CCAAGGAGGTCAGCAGCAGCACAGAGCTGCACTCCAATGAGAAGTGGTTCCATGGGAAGCTAGGGGCAGGGCGTGACGGGCGTCACATCG
CTGAGCGCCTGCTTACTGAGTACTGCATCGAGACCGGAGCCCCTGACGGCTCCTTCCTCGTGCGAGAGAGTGAGACCTTCGTGGGCGACT
ACACGCTCTCTTTCTGGCGGAACGGGAAAGTCCAGCACTGCCGTATCCACTCCCGGCAAGATGCTGGGACCCCCAAGTTCTTCTTGACAG
ACAACCTCGTCTTTGACTCCCTCTATGACCTCATCACGCACTACCAGCAGGTGCCCCTGCGCTGTAATGAGTTTGAGATGCGACTTTCAG
AGCCTGTCCCACAGACCAACGCCCACGAGAGCAAAGAGTGGTACCACGCGAGCCTGACCAGAGCACAGGCTGAGCACATGCTAATGCGCG
TCCCTCGTGATGGGGCCTTCCTGGTGCGGAAGCGGAATGAACCCAACTCATATGCCATCTCTTTCCGGGCTGAGGGCAAGATCAAGCATT
GCCGTGTCCAGCAAGAGGGCCAGACAGTGATGCTAGGGAACTCGGAGTTCGACAGCCTTGTTGACCTCATCAGCTACTATGAGAAACACC
CGCTATACCGCAAGATGAAGCTGCGCTATCCCATCAACGAGGAGGCACTGGAGAAGATTGGCACAGCTGAGCCTGACTACGGGGCCCTGT
ATGAGGGACGCAACCCTGGCTTCTATGTAGAGGCAAACCCTATGCCAACTTTCAAGTGTGCAGTCAAAGCCCTCTTTGACTACAAGGCCC
AGAGGGAGGACGAGCTGACCTTCATCAAGAGCGCCATCATCCAGAATGTGGAGAAGCAAGAGGGAGGCTGGTGGCGAGGGGACTACGGAG
GGAAGAAGCAGCTGTGGTTCCCATCAAACTACGTGGAAGAGATGGTCAACCCCGTGGCCCTGGAGCCGGAGAGGGAGCACTTGGACGAGA
ACAGCCCCCTAGGGGACTTGCTGCGGGGGGTCTTGGATGTGCCGGCTTGTCAGATTGCCATCCGTCCTGAGGGCAAGAACAACCGGCTCT
TCGTCTTCTCCATCAGCATGGCGTCGGTGGCCCACTGGTCCCTGGATGTTGCTGCCGACTCACAGGAGGAGCTGCAGGACTGGGTGAAAA
AGATCCGTGAAGTGGCCCAGACAGCAGACGCCAGGGATTGTGACCAGATCCACGTTGATGACGTCTCATCAGATGACAATGGCCAAGATT
TAAGCACATACAACTTCTCCGCTGACGGCTTCCACAGTTCGGCCCCAGGAGCCAACCTGTGCCTGGGCTCTGGCGTGCACGGCGGCGTGG
ACTGGATGAGGAAGCTGGCCTTCCGCTACCGGCGGGTGAAGGAGATGTACAATACCTACAAGAACAACGTTGGTGGGTTGATAGGCACTC
CCAAAAGGGAGACCTGGCTACAGCTCCGAGCTGAGCTGGAAGCTCTCACAGACCTCTGGCTGACCCACTCCCTGAAGGCACTAAACCTCA
TCAACTCCCGGCCCAACTGTGTCAATGTGCTGGTCACCACCACTCAACTAATTCCTGCCCTGGCCAAAGTCCTGCTATATGGCCTGGGGT
CTGTGTTTCCTATTGAGAACATCTACAGTGCAACCAAGACAGGGAAGGAGAGCTGCTTCGAGAGGATAATGCAGAGATTCGGCAGAAAAG
CTGTCTACGTGGTGATCGGTGATGGTGTGGAAGAGGAGCAAGGAGCGAAAAAGCACAACATGCCTTTCTGGCGGATATCCTGCCACGCAG
ACCTGGAGGCACTGAGGCACGCCCTGGAGCTGGAGTATTTATAGCAGGATCAGCAGCATCTCCACCTGCCATCTCACCCTCAGACCCCCT
CGCCTTCCCCACCTCCCCACCGAGAACTCCAGAGACCCAGATGTTGGACACCAGGAAGGGGCCCCACAGCCGAGACGACGTGTCCAGTGA
CCATCTCAGAAGCCGTCCATCAGTCCAAATGGGGGTTCTGAGAAGGAAAGTACCCAACATTGGCTTCGGAGTATTTGACTTTGGGGAAAA
GGGCTGGCTCGGAGTCTAGACTCTTCTGTAAGACTCACAGAACAAAAGCAAGGAATTGCTGATTTGGGGGGTGCCTGGTGATGAGGAGGG
GATGGGTTTGTCTTGTCTTCTTTTTAATTTATGGACTAGTCTCATTACTCCGGAATTATGCTCTTGTACCTGTGTGGCTGGGTTTCTTAG
TCGTTGGTTTGGTTTGGTTTTTTGAACTGGTATGTGGGGTGGTTCACAGTTCTAATGTAAGCACTCTATTCTCCAAGTTGTGCTTTGTGG
GGACAATCATTCTTTGAACATTAGAGAGGAAGGCAGTTCAAGCTGTTGAAAAGACTATTGCTTATTTTTGTTTTTAAAGACCTACTTGAC
GTCATGTGGACAGTGCACGTGCCTTACGCTACATCTTGTTTTCTAGGAAGAGGGGGATGCTGGGAAGGAATGGGTGCTTTGTGATGGATA

>66023_66023_1_PLCG1-EYA2_PLCG1_chr20_39798909_ENST00000244007_EYA2_chr20_45797786_ENST00000327619_length(amino acids)=1160AA_BP=948
MACAAAAPSVGAMAGAASPCANGCGPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQITWSRGADKIEGAIDIREI
KEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWIKGLTWLMEDTLQAPTPLQIERWLRKQFYSVDRNR
EDRISAKDLKNMLSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRAGERPELCRVSLPEFQQFL
LDYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVTFLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSES
SLEAYARCLRMGCRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQRNMAQYFKKVLGDTLL
TKPVEISADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSMMYSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQG
NEDEEEPKEVSSSTELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFWRNGKVQHCRIHSRQDAGT
PKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQTNAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRA
EGKIKHCRVQQEGQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNPGFYVEANPMPTFKCAVKA
LFDYKAQREDELTFIKSAIIQNVEKQEGGWWRGDYGGKKQLWFPSNYVEEMVNPVALEPEREHLDENSPLGDLLRGVLDVPACQIAIRPE
GKNNRLFVFSISMASVAHWSLDVAADSQEELQDWVKKIREVAQTADARDCDQIHVDDVSSDDNGQDLSTYNFSADGFHSSAPGANLCLGS
GVHGGVDWMRKLAFRYRRVKEMYNTYKNNVGGLIGTPKRETWLQLRAELEALTDLWLTHSLKALNLINSRPNCVNVLVTTTQLIPALAKV

--------------------------------------------------------------
>66023_66023_2_PLCG1-EYA2_PLCG1_chr20_39798909_ENST00000244007_EYA2_chr20_45797786_ENST00000357410_length(transcript)=4118nt_BP=3005nt
GAGGGCGCGCGGAGGACCCGCCGCCGCCGGTGTGAGGCGGCCCGTCCTGGCTCCCTTGTCCGGGAAGCCCGCCCAGGAGCCGCCGCCGGG
TCCCGCTCGTCTGCCGCCTCAGCCTCAGCCCCAACCTCAGCCGCCGCCGTTGCGCTTGCTCCCGGGCGGTCCTGGCCTGTGCCGCCGCCG
CCCCCAGCGTCGGAGCCATGGCGGGCGCCGCGTCCCCTTGCGCCAACGGCTGCGGGCCCGGCGCGCCCTCGGACGCCGAGGTGCTGCACC
TCTGCCGCAGCCTCGAGGTGGGCACCGTCATGACTTTGTTCTACTCCAAGAAGTCGCAGCGACCCGAGCGGAAGACCTTCCAGGTCAAGC
TGGAGACGCGCCAGATCACGTGGAGCCGGGGCGCCGACAAGATCGAGGGGGCCATTGACATTCGTGAAATTAAGGAGATCCGCCCAGGGA
AGACCTCACGGGACTTTGATCGCTATCAAGAGGACCCAGCTTTCCGGCCGGACCAGTCACATTGCTTTGTCATTCTCTATGGAATGGAAT
TTCGCCTGAAAACGCTGAGCCTGCAAGCCACATCTGAGGATGAAGTGAACATGTGGATCAAGGGCTTAACTTGGCTGATGGAGGATACAT
TGCAGGCACCCACACCCCTGCAGATTGAGAGGTGGCTCCGGAAGCAGTTTTACTCAGTGGATCGGAATCGTGAGGATCGTATATCAGCCA
AGGACCTGAAGAACATGCTGTCCCAGGTCAACTACCGGGTCCCCAACATGCGCTTCCTCCGAGAGCGGCTGACGGACCTGGAGCAGCGCA
GCGGGGACATCACCTACGGGCAGTTTGCTCAGCTGTACCGCAGCCTCATGTACAGCGCCCAGAAGACGATGGACCTCCCCTTCTTGGAAG
CCAGTACTCTGAGGGCTGGGGAGCGGCCGGAGCTTTGCCGAGTGTCCCTTCCTGAGTTCCAGCAGTTCCTTCTTGACTACCAGGGGGAGC
TGTGGGCTGTTGATCGCCTCCAGGTGCAGGAGTTCATGCTCAGCTTCCTCCGAGACCCCTTACGAGAGATCGAGGAGCCATACTTCTTCC
TGGATGAGTTTGTCACCTTCCTGTTCTCCAAAGAGAACAGTGTGTGGAACTCGCAGCTGGATGCAGTATGCCCGGACACCATGAACAACC
CTCTTTCCCACTACTGGATCTCCTCCTCGCACAACACGTACCTGACCGGGGACCAGTTCTCCAGTGAGTCCTCCTTGGAAGCCTATGCTC
GCTGCCTGCGGATGGGCTGTCGCTGCATTGAGTTGGACTGCTGGGACGGCCCGGATGGGATGCCAGTTATTTACCATGGGCACACCCTTA
CCACCAAGATCAAGTTCTCAGATGTCCTGCACACCATCAAGGAGCATGCCTTTGTGGCCTCAGAGTACCCAGTCATCCTGTCCATTGAGG
ACCACTGCAGCATTGCCCAGCAGAGAAACATGGCCCAATACTTCAAGAAGGTGCTGGGGGACACACTCCTCACCAAGCCCGTGGAGATCT
CTGCCGACGGGCTCCCCTCACCCAACCAGCTTAAGAGGAAGATCCTCATCAAGCACAAGAAGCTGGCTGAGGGCAGTGCCTACGAGGAGG
TGCCTACATCCATGATGTACTCTGAGAACGACATCAGCAACTCTATCAAGAATGGCATCCTCTACCTGGAGGACCCTGTGAACCACGAAT
GGTATCCCCACTACTTTGTTCTGACCAGCAGCAAGATCTACTACTCTGAGGAGACCAGCAGTGACCAGGGCAACGAGGATGAGGAGGAGC
CCAAGGAGGTCAGCAGCAGCACAGAGCTGCACTCCAATGAGAAGTGGTTCCATGGGAAGCTAGGGGCAGGGCGTGACGGGCGTCACATCG
CTGAGCGCCTGCTTACTGAGTACTGCATCGAGACCGGAGCCCCTGACGGCTCCTTCCTCGTGCGAGAGAGTGAGACCTTCGTGGGCGACT
ACACGCTCTCTTTCTGGCGGAACGGGAAAGTCCAGCACTGCCGTATCCACTCCCGGCAAGATGCTGGGACCCCCAAGTTCTTCTTGACAG
ACAACCTCGTCTTTGACTCCCTCTATGACCTCATCACGCACTACCAGCAGGTGCCCCTGCGCTGTAATGAGTTTGAGATGCGACTTTCAG
AGCCTGTCCCACAGACCAACGCCCACGAGAGCAAAGAGTGGTACCACGCGAGCCTGACCAGAGCACAGGCTGAGCACATGCTAATGCGCG
TCCCTCGTGATGGGGCCTTCCTGGTGCGGAAGCGGAATGAACCCAACTCATATGCCATCTCTTTCCGGGCTGAGGGCAAGATCAAGCATT
GCCGTGTCCAGCAAGAGGGCCAGACAGTGATGCTAGGGAACTCGGAGTTCGACAGCCTTGTTGACCTCATCAGCTACTATGAGAAACACC
CGCTATACCGCAAGATGAAGCTGCGCTATCCCATCAACGAGGAGGCACTGGAGAAGATTGGCACAGCTGAGCCTGACTACGGGGCCCTGT
ATGAGGGACGCAACCCTGGCTTCTATGTAGAGGCAAACCCTATGCCAACTTTCAAGTGTGCAGTCAAAGCCCTCTTTGACTACAAGGCCC
AGAGGGAGGACGAGCTGACCTTCATCAAGAGCGCCATCATCCAGAATGTGGAGAAGCAAGAGGGAGGCTGGTGGCGAGGGGACTACGGAG
GGAAGAAGCAGCTGTGGTTCCCATCAAACTACGTGGAAGAGATGGTCAACCCCGTGGCCCTGGAGCCGGAGAGGGAGCACTTGGACGAGA
ACAGCCCCCTAGGGGACTTGCTGCGGGGGGTCTTGGATGTGCCGGCTTGTCAGATTGCCATCCGTCCTGAGGGCAAGAACAACCGGCTCT
TCGTCTTCTCCATCAGCATGGCGTCGGTGGCCCACTGGTCCCTGGATGTTGCTGCCGACTCACAGGAGGAGCTGCAGGACTGGGTGAAAA
AGATCCGTGAAGTGGCCCAGACAGCAGACGCCAGGGATTGTGACCAGATCCACGTTGATGACGTCTCATCAGATGACAATGGCCAAGATT
TAAGCACATACAACTTCTCCGCTGACGGCTTCCACAGTTCGGCCCCAGGAGCCAACCTGTGCCTGGGCTCTGGCGTGCACGGCGGCGTGG
ACTGGATGAGGAAGCTGGCCTTCCGCTACCGGCGGGTGAAGGAGATGTACAATACCTACAAGAACAACGTTGGTGGGAAGGAGAGCTGCT
TCGAGAGGATAATGCAGAGATTCGGCAGAAAAGCTGTCTACGTGGTGATCGGTGATGGTGTGGAAGAGGAGCAAGGAGCGAAAAAGCACA
ACATGCCTTTCTGGCGGATATCCTGCCACGCAGACCTGGAGGCACTGAGGCACGCCCTGGAGCTGGAGTATTTATAGCAGGATCAGCAGC
ATCTCCACCTGCCATCTCACCCTCAGACCCCCTCGCCTTCCCCACCTCCCCACCGAGAACTCCAGAGACCCAGATGTTGGACACCAGGAA
GGGGCCCCACAGCCGAGACGACGTGTCCAGTGACCATCTCAGAAGCCGTCCATCAGTCCAAATGGGGGTTCTGAGAAGGAAAGTACCCAA
CATTGGCTTCGGAGTATTTGACTTTGGGGAAAAGGGCTGGCTCGGAGTCTAGACTCTTCTGTAAGACTCACAGAACAAAAGCAAGGAATT
GCTGATTTGGGGGGTGCCTGGTGATGAGGAGGGGATGGGTTTGTCTTGTCTTCTTTTTAATTTATGGACTAGTCTCATTACTCCGGAATT
ATGCTCTTGTACCTGTGTGGCTGGGTTTCTTAGTCGTTGGTTTGGTTTGGTTTTTTGAACTGGTATGTGGGGTGGTTCACAGTTCTAATG
TAAGCACTCTATTCTCCAAGTTGTGCTTTGTGGGGACAATCATTCTTTGAACATTAGAGAGGAAGGCAGTTCAAGCTGTTGAAAAGACTA
TTGCTTATTTTTGTTTTTAAAGACCTACTTGACGTCATGTGGACAGTGCACGTGCCTTACGCTACATCTTGTTTTCTAGGAAGAGGGGGA

>66023_66023_2_PLCG1-EYA2_PLCG1_chr20_39798909_ENST00000244007_EYA2_chr20_45797786_ENST00000357410_length(amino acids)=1081AA_BP=948
MACAAAAPSVGAMAGAASPCANGCGPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQITWSRGADKIEGAIDIREI
KEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWIKGLTWLMEDTLQAPTPLQIERWLRKQFYSVDRNR
EDRISAKDLKNMLSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRAGERPELCRVSLPEFQQFL
LDYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVTFLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSES
SLEAYARCLRMGCRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQRNMAQYFKKVLGDTLL
TKPVEISADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSMMYSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQG
NEDEEEPKEVSSSTELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFWRNGKVQHCRIHSRQDAGT
PKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQTNAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRA
EGKIKHCRVQQEGQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNPGFYVEANPMPTFKCAVKA
LFDYKAQREDELTFIKSAIIQNVEKQEGGWWRGDYGGKKQLWFPSNYVEEMVNPVALEPEREHLDENSPLGDLLRGVLDVPACQIAIRPE
GKNNRLFVFSISMASVAHWSLDVAADSQEELQDWVKKIREVAQTADARDCDQIHVDDVSSDDNGQDLSTYNFSADGFHSSAPGANLCLGS
GVHGGVDWMRKLAFRYRRVKEMYNTYKNNVGGKESCFERIMQRFGRKAVYVVIGDGVEEEQGAKKHNMPFWRISCHADLEALRHALELEY

--------------------------------------------------------------
>66023_66023_3_PLCG1-EYA2_PLCG1_chr20_39798909_ENST00000244007_EYA2_chr20_45797787_ENST00000327619_length(transcript)=4355nt_BP=3005nt
GAGGGCGCGCGGAGGACCCGCCGCCGCCGGTGTGAGGCGGCCCGTCCTGGCTCCCTTGTCCGGGAAGCCCGCCCAGGAGCCGCCGCCGGG
TCCCGCTCGTCTGCCGCCTCAGCCTCAGCCCCAACCTCAGCCGCCGCCGTTGCGCTTGCTCCCGGGCGGTCCTGGCCTGTGCCGCCGCCG
CCCCCAGCGTCGGAGCCATGGCGGGCGCCGCGTCCCCTTGCGCCAACGGCTGCGGGCCCGGCGCGCCCTCGGACGCCGAGGTGCTGCACC
TCTGCCGCAGCCTCGAGGTGGGCACCGTCATGACTTTGTTCTACTCCAAGAAGTCGCAGCGACCCGAGCGGAAGACCTTCCAGGTCAAGC
TGGAGACGCGCCAGATCACGTGGAGCCGGGGCGCCGACAAGATCGAGGGGGCCATTGACATTCGTGAAATTAAGGAGATCCGCCCAGGGA
AGACCTCACGGGACTTTGATCGCTATCAAGAGGACCCAGCTTTCCGGCCGGACCAGTCACATTGCTTTGTCATTCTCTATGGAATGGAAT
TTCGCCTGAAAACGCTGAGCCTGCAAGCCACATCTGAGGATGAAGTGAACATGTGGATCAAGGGCTTAACTTGGCTGATGGAGGATACAT
TGCAGGCACCCACACCCCTGCAGATTGAGAGGTGGCTCCGGAAGCAGTTTTACTCAGTGGATCGGAATCGTGAGGATCGTATATCAGCCA
AGGACCTGAAGAACATGCTGTCCCAGGTCAACTACCGGGTCCCCAACATGCGCTTCCTCCGAGAGCGGCTGACGGACCTGGAGCAGCGCA
GCGGGGACATCACCTACGGGCAGTTTGCTCAGCTGTACCGCAGCCTCATGTACAGCGCCCAGAAGACGATGGACCTCCCCTTCTTGGAAG
CCAGTACTCTGAGGGCTGGGGAGCGGCCGGAGCTTTGCCGAGTGTCCCTTCCTGAGTTCCAGCAGTTCCTTCTTGACTACCAGGGGGAGC
TGTGGGCTGTTGATCGCCTCCAGGTGCAGGAGTTCATGCTCAGCTTCCTCCGAGACCCCTTACGAGAGATCGAGGAGCCATACTTCTTCC
TGGATGAGTTTGTCACCTTCCTGTTCTCCAAAGAGAACAGTGTGTGGAACTCGCAGCTGGATGCAGTATGCCCGGACACCATGAACAACC
CTCTTTCCCACTACTGGATCTCCTCCTCGCACAACACGTACCTGACCGGGGACCAGTTCTCCAGTGAGTCCTCCTTGGAAGCCTATGCTC
GCTGCCTGCGGATGGGCTGTCGCTGCATTGAGTTGGACTGCTGGGACGGCCCGGATGGGATGCCAGTTATTTACCATGGGCACACCCTTA
CCACCAAGATCAAGTTCTCAGATGTCCTGCACACCATCAAGGAGCATGCCTTTGTGGCCTCAGAGTACCCAGTCATCCTGTCCATTGAGG
ACCACTGCAGCATTGCCCAGCAGAGAAACATGGCCCAATACTTCAAGAAGGTGCTGGGGGACACACTCCTCACCAAGCCCGTGGAGATCT
CTGCCGACGGGCTCCCCTCACCCAACCAGCTTAAGAGGAAGATCCTCATCAAGCACAAGAAGCTGGCTGAGGGCAGTGCCTACGAGGAGG
TGCCTACATCCATGATGTACTCTGAGAACGACATCAGCAACTCTATCAAGAATGGCATCCTCTACCTGGAGGACCCTGTGAACCACGAAT
GGTATCCCCACTACTTTGTTCTGACCAGCAGCAAGATCTACTACTCTGAGGAGACCAGCAGTGACCAGGGCAACGAGGATGAGGAGGAGC
CCAAGGAGGTCAGCAGCAGCACAGAGCTGCACTCCAATGAGAAGTGGTTCCATGGGAAGCTAGGGGCAGGGCGTGACGGGCGTCACATCG
CTGAGCGCCTGCTTACTGAGTACTGCATCGAGACCGGAGCCCCTGACGGCTCCTTCCTCGTGCGAGAGAGTGAGACCTTCGTGGGCGACT
ACACGCTCTCTTTCTGGCGGAACGGGAAAGTCCAGCACTGCCGTATCCACTCCCGGCAAGATGCTGGGACCCCCAAGTTCTTCTTGACAG
ACAACCTCGTCTTTGACTCCCTCTATGACCTCATCACGCACTACCAGCAGGTGCCCCTGCGCTGTAATGAGTTTGAGATGCGACTTTCAG
AGCCTGTCCCACAGACCAACGCCCACGAGAGCAAAGAGTGGTACCACGCGAGCCTGACCAGAGCACAGGCTGAGCACATGCTAATGCGCG
TCCCTCGTGATGGGGCCTTCCTGGTGCGGAAGCGGAATGAACCCAACTCATATGCCATCTCTTTCCGGGCTGAGGGCAAGATCAAGCATT
GCCGTGTCCAGCAAGAGGGCCAGACAGTGATGCTAGGGAACTCGGAGTTCGACAGCCTTGTTGACCTCATCAGCTACTATGAGAAACACC
CGCTATACCGCAAGATGAAGCTGCGCTATCCCATCAACGAGGAGGCACTGGAGAAGATTGGCACAGCTGAGCCTGACTACGGGGCCCTGT
ATGAGGGACGCAACCCTGGCTTCTATGTAGAGGCAAACCCTATGCCAACTTTCAAGTGTGCAGTCAAAGCCCTCTTTGACTACAAGGCCC
AGAGGGAGGACGAGCTGACCTTCATCAAGAGCGCCATCATCCAGAATGTGGAGAAGCAAGAGGGAGGCTGGTGGCGAGGGGACTACGGAG
GGAAGAAGCAGCTGTGGTTCCCATCAAACTACGTGGAAGAGATGGTCAACCCCGTGGCCCTGGAGCCGGAGAGGGAGCACTTGGACGAGA
ACAGCCCCCTAGGGGACTTGCTGCGGGGGGTCTTGGATGTGCCGGCTTGTCAGATTGCCATCCGTCCTGAGGGCAAGAACAACCGGCTCT
TCGTCTTCTCCATCAGCATGGCGTCGGTGGCCCACTGGTCCCTGGATGTTGCTGCCGACTCACAGGAGGAGCTGCAGGACTGGGTGAAAA
AGATCCGTGAAGTGGCCCAGACAGCAGACGCCAGGGATTGTGACCAGATCCACGTTGATGACGTCTCATCAGATGACAATGGCCAAGATT
TAAGCACATACAACTTCTCCGCTGACGGCTTCCACAGTTCGGCCCCAGGAGCCAACCTGTGCCTGGGCTCTGGCGTGCACGGCGGCGTGG
ACTGGATGAGGAAGCTGGCCTTCCGCTACCGGCGGGTGAAGGAGATGTACAATACCTACAAGAACAACGTTGGTGGGTTGATAGGCACTC
CCAAAAGGGAGACCTGGCTACAGCTCCGAGCTGAGCTGGAAGCTCTCACAGACCTCTGGCTGACCCACTCCCTGAAGGCACTAAACCTCA
TCAACTCCCGGCCCAACTGTGTCAATGTGCTGGTCACCACCACTCAACTAATTCCTGCCCTGGCCAAAGTCCTGCTATATGGCCTGGGGT
CTGTGTTTCCTATTGAGAACATCTACAGTGCAACCAAGACAGGGAAGGAGAGCTGCTTCGAGAGGATAATGCAGAGATTCGGCAGAAAAG
CTGTCTACGTGGTGATCGGTGATGGTGTGGAAGAGGAGCAAGGAGCGAAAAAGCACAACATGCCTTTCTGGCGGATATCCTGCCACGCAG
ACCTGGAGGCACTGAGGCACGCCCTGGAGCTGGAGTATTTATAGCAGGATCAGCAGCATCTCCACCTGCCATCTCACCCTCAGACCCCCT
CGCCTTCCCCACCTCCCCACCGAGAACTCCAGAGACCCAGATGTTGGACACCAGGAAGGGGCCCCACAGCCGAGACGACGTGTCCAGTGA
CCATCTCAGAAGCCGTCCATCAGTCCAAATGGGGGTTCTGAGAAGGAAAGTACCCAACATTGGCTTCGGAGTATTTGACTTTGGGGAAAA
GGGCTGGCTCGGAGTCTAGACTCTTCTGTAAGACTCACAGAACAAAAGCAAGGAATTGCTGATTTGGGGGGTGCCTGGTGATGAGGAGGG
GATGGGTTTGTCTTGTCTTCTTTTTAATTTATGGACTAGTCTCATTACTCCGGAATTATGCTCTTGTACCTGTGTGGCTGGGTTTCTTAG
TCGTTGGTTTGGTTTGGTTTTTTGAACTGGTATGTGGGGTGGTTCACAGTTCTAATGTAAGCACTCTATTCTCCAAGTTGTGCTTTGTGG
GGACAATCATTCTTTGAACATTAGAGAGGAAGGCAGTTCAAGCTGTTGAAAAGACTATTGCTTATTTTTGTTTTTAAAGACCTACTTGAC
GTCATGTGGACAGTGCACGTGCCTTACGCTACATCTTGTTTTCTAGGAAGAGGGGGATGCTGGGAAGGAATGGGTGCTTTGTGATGGATA

>66023_66023_3_PLCG1-EYA2_PLCG1_chr20_39798909_ENST00000244007_EYA2_chr20_45797787_ENST00000327619_length(amino acids)=1160AA_BP=948
MACAAAAPSVGAMAGAASPCANGCGPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQITWSRGADKIEGAIDIREI
KEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWIKGLTWLMEDTLQAPTPLQIERWLRKQFYSVDRNR
EDRISAKDLKNMLSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRAGERPELCRVSLPEFQQFL
LDYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVTFLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSES
SLEAYARCLRMGCRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQRNMAQYFKKVLGDTLL
TKPVEISADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSMMYSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQG
NEDEEEPKEVSSSTELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFWRNGKVQHCRIHSRQDAGT
PKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQTNAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRA
EGKIKHCRVQQEGQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNPGFYVEANPMPTFKCAVKA
LFDYKAQREDELTFIKSAIIQNVEKQEGGWWRGDYGGKKQLWFPSNYVEEMVNPVALEPEREHLDENSPLGDLLRGVLDVPACQIAIRPE
GKNNRLFVFSISMASVAHWSLDVAADSQEELQDWVKKIREVAQTADARDCDQIHVDDVSSDDNGQDLSTYNFSADGFHSSAPGANLCLGS
GVHGGVDWMRKLAFRYRRVKEMYNTYKNNVGGLIGTPKRETWLQLRAELEALTDLWLTHSLKALNLINSRPNCVNVLVTTTQLIPALAKV

--------------------------------------------------------------
>66023_66023_4_PLCG1-EYA2_PLCG1_chr20_39798909_ENST00000244007_EYA2_chr20_45797787_ENST00000357410_length(transcript)=4118nt_BP=3005nt
GAGGGCGCGCGGAGGACCCGCCGCCGCCGGTGTGAGGCGGCCCGTCCTGGCTCCCTTGTCCGGGAAGCCCGCCCAGGAGCCGCCGCCGGG
TCCCGCTCGTCTGCCGCCTCAGCCTCAGCCCCAACCTCAGCCGCCGCCGTTGCGCTTGCTCCCGGGCGGTCCTGGCCTGTGCCGCCGCCG
CCCCCAGCGTCGGAGCCATGGCGGGCGCCGCGTCCCCTTGCGCCAACGGCTGCGGGCCCGGCGCGCCCTCGGACGCCGAGGTGCTGCACC
TCTGCCGCAGCCTCGAGGTGGGCACCGTCATGACTTTGTTCTACTCCAAGAAGTCGCAGCGACCCGAGCGGAAGACCTTCCAGGTCAAGC
TGGAGACGCGCCAGATCACGTGGAGCCGGGGCGCCGACAAGATCGAGGGGGCCATTGACATTCGTGAAATTAAGGAGATCCGCCCAGGGA
AGACCTCACGGGACTTTGATCGCTATCAAGAGGACCCAGCTTTCCGGCCGGACCAGTCACATTGCTTTGTCATTCTCTATGGAATGGAAT
TTCGCCTGAAAACGCTGAGCCTGCAAGCCACATCTGAGGATGAAGTGAACATGTGGATCAAGGGCTTAACTTGGCTGATGGAGGATACAT
TGCAGGCACCCACACCCCTGCAGATTGAGAGGTGGCTCCGGAAGCAGTTTTACTCAGTGGATCGGAATCGTGAGGATCGTATATCAGCCA
AGGACCTGAAGAACATGCTGTCCCAGGTCAACTACCGGGTCCCCAACATGCGCTTCCTCCGAGAGCGGCTGACGGACCTGGAGCAGCGCA
GCGGGGACATCACCTACGGGCAGTTTGCTCAGCTGTACCGCAGCCTCATGTACAGCGCCCAGAAGACGATGGACCTCCCCTTCTTGGAAG
CCAGTACTCTGAGGGCTGGGGAGCGGCCGGAGCTTTGCCGAGTGTCCCTTCCTGAGTTCCAGCAGTTCCTTCTTGACTACCAGGGGGAGC
TGTGGGCTGTTGATCGCCTCCAGGTGCAGGAGTTCATGCTCAGCTTCCTCCGAGACCCCTTACGAGAGATCGAGGAGCCATACTTCTTCC
TGGATGAGTTTGTCACCTTCCTGTTCTCCAAAGAGAACAGTGTGTGGAACTCGCAGCTGGATGCAGTATGCCCGGACACCATGAACAACC
CTCTTTCCCACTACTGGATCTCCTCCTCGCACAACACGTACCTGACCGGGGACCAGTTCTCCAGTGAGTCCTCCTTGGAAGCCTATGCTC
GCTGCCTGCGGATGGGCTGTCGCTGCATTGAGTTGGACTGCTGGGACGGCCCGGATGGGATGCCAGTTATTTACCATGGGCACACCCTTA
CCACCAAGATCAAGTTCTCAGATGTCCTGCACACCATCAAGGAGCATGCCTTTGTGGCCTCAGAGTACCCAGTCATCCTGTCCATTGAGG
ACCACTGCAGCATTGCCCAGCAGAGAAACATGGCCCAATACTTCAAGAAGGTGCTGGGGGACACACTCCTCACCAAGCCCGTGGAGATCT
CTGCCGACGGGCTCCCCTCACCCAACCAGCTTAAGAGGAAGATCCTCATCAAGCACAAGAAGCTGGCTGAGGGCAGTGCCTACGAGGAGG
TGCCTACATCCATGATGTACTCTGAGAACGACATCAGCAACTCTATCAAGAATGGCATCCTCTACCTGGAGGACCCTGTGAACCACGAAT
GGTATCCCCACTACTTTGTTCTGACCAGCAGCAAGATCTACTACTCTGAGGAGACCAGCAGTGACCAGGGCAACGAGGATGAGGAGGAGC
CCAAGGAGGTCAGCAGCAGCACAGAGCTGCACTCCAATGAGAAGTGGTTCCATGGGAAGCTAGGGGCAGGGCGTGACGGGCGTCACATCG
CTGAGCGCCTGCTTACTGAGTACTGCATCGAGACCGGAGCCCCTGACGGCTCCTTCCTCGTGCGAGAGAGTGAGACCTTCGTGGGCGACT
ACACGCTCTCTTTCTGGCGGAACGGGAAAGTCCAGCACTGCCGTATCCACTCCCGGCAAGATGCTGGGACCCCCAAGTTCTTCTTGACAG
ACAACCTCGTCTTTGACTCCCTCTATGACCTCATCACGCACTACCAGCAGGTGCCCCTGCGCTGTAATGAGTTTGAGATGCGACTTTCAG
AGCCTGTCCCACAGACCAACGCCCACGAGAGCAAAGAGTGGTACCACGCGAGCCTGACCAGAGCACAGGCTGAGCACATGCTAATGCGCG
TCCCTCGTGATGGGGCCTTCCTGGTGCGGAAGCGGAATGAACCCAACTCATATGCCATCTCTTTCCGGGCTGAGGGCAAGATCAAGCATT
GCCGTGTCCAGCAAGAGGGCCAGACAGTGATGCTAGGGAACTCGGAGTTCGACAGCCTTGTTGACCTCATCAGCTACTATGAGAAACACC
CGCTATACCGCAAGATGAAGCTGCGCTATCCCATCAACGAGGAGGCACTGGAGAAGATTGGCACAGCTGAGCCTGACTACGGGGCCCTGT
ATGAGGGACGCAACCCTGGCTTCTATGTAGAGGCAAACCCTATGCCAACTTTCAAGTGTGCAGTCAAAGCCCTCTTTGACTACAAGGCCC
AGAGGGAGGACGAGCTGACCTTCATCAAGAGCGCCATCATCCAGAATGTGGAGAAGCAAGAGGGAGGCTGGTGGCGAGGGGACTACGGAG
GGAAGAAGCAGCTGTGGTTCCCATCAAACTACGTGGAAGAGATGGTCAACCCCGTGGCCCTGGAGCCGGAGAGGGAGCACTTGGACGAGA
ACAGCCCCCTAGGGGACTTGCTGCGGGGGGTCTTGGATGTGCCGGCTTGTCAGATTGCCATCCGTCCTGAGGGCAAGAACAACCGGCTCT
TCGTCTTCTCCATCAGCATGGCGTCGGTGGCCCACTGGTCCCTGGATGTTGCTGCCGACTCACAGGAGGAGCTGCAGGACTGGGTGAAAA
AGATCCGTGAAGTGGCCCAGACAGCAGACGCCAGGGATTGTGACCAGATCCACGTTGATGACGTCTCATCAGATGACAATGGCCAAGATT
TAAGCACATACAACTTCTCCGCTGACGGCTTCCACAGTTCGGCCCCAGGAGCCAACCTGTGCCTGGGCTCTGGCGTGCACGGCGGCGTGG
ACTGGATGAGGAAGCTGGCCTTCCGCTACCGGCGGGTGAAGGAGATGTACAATACCTACAAGAACAACGTTGGTGGGAAGGAGAGCTGCT
TCGAGAGGATAATGCAGAGATTCGGCAGAAAAGCTGTCTACGTGGTGATCGGTGATGGTGTGGAAGAGGAGCAAGGAGCGAAAAAGCACA
ACATGCCTTTCTGGCGGATATCCTGCCACGCAGACCTGGAGGCACTGAGGCACGCCCTGGAGCTGGAGTATTTATAGCAGGATCAGCAGC
ATCTCCACCTGCCATCTCACCCTCAGACCCCCTCGCCTTCCCCACCTCCCCACCGAGAACTCCAGAGACCCAGATGTTGGACACCAGGAA
GGGGCCCCACAGCCGAGACGACGTGTCCAGTGACCATCTCAGAAGCCGTCCATCAGTCCAAATGGGGGTTCTGAGAAGGAAAGTACCCAA
CATTGGCTTCGGAGTATTTGACTTTGGGGAAAAGGGCTGGCTCGGAGTCTAGACTCTTCTGTAAGACTCACAGAACAAAAGCAAGGAATT
GCTGATTTGGGGGGTGCCTGGTGATGAGGAGGGGATGGGTTTGTCTTGTCTTCTTTTTAATTTATGGACTAGTCTCATTACTCCGGAATT
ATGCTCTTGTACCTGTGTGGCTGGGTTTCTTAGTCGTTGGTTTGGTTTGGTTTTTTGAACTGGTATGTGGGGTGGTTCACAGTTCTAATG
TAAGCACTCTATTCTCCAAGTTGTGCTTTGTGGGGACAATCATTCTTTGAACATTAGAGAGGAAGGCAGTTCAAGCTGTTGAAAAGACTA
TTGCTTATTTTTGTTTTTAAAGACCTACTTGACGTCATGTGGACAGTGCACGTGCCTTACGCTACATCTTGTTTTCTAGGAAGAGGGGGA

>66023_66023_4_PLCG1-EYA2_PLCG1_chr20_39798909_ENST00000244007_EYA2_chr20_45797787_ENST00000357410_length(amino acids)=1081AA_BP=948
MACAAAAPSVGAMAGAASPCANGCGPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQITWSRGADKIEGAIDIREI
KEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWIKGLTWLMEDTLQAPTPLQIERWLRKQFYSVDRNR
EDRISAKDLKNMLSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRAGERPELCRVSLPEFQQFL
LDYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVTFLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSES
SLEAYARCLRMGCRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQRNMAQYFKKVLGDTLL
TKPVEISADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSMMYSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQG
NEDEEEPKEVSSSTELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFWRNGKVQHCRIHSRQDAGT
PKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQTNAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRA
EGKIKHCRVQQEGQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNPGFYVEANPMPTFKCAVKA
LFDYKAQREDELTFIKSAIIQNVEKQEGGWWRGDYGGKKQLWFPSNYVEEMVNPVALEPEREHLDENSPLGDLLRGVLDVPACQIAIRPE
GKNNRLFVFSISMASVAHWSLDVAADSQEELQDWVKKIREVAQTADARDCDQIHVDDVSSDDNGQDLSTYNFSADGFHSSAPGANLCLGS
GVHGGVDWMRKLAFRYRRVKEMYNTYKNNVGGKESCFERIMQRFGRKAVYVVIGDGVEEEQGAKKHNMPFWRISCHADLEALRHALELEY

--------------------------------------------------------------
>66023_66023_5_PLCG1-EYA2_PLCG1_chr20_39798909_ENST00000373271_EYA2_chr20_45797786_ENST00000327619_length(transcript)=4563nt_BP=3213nt
GCCGCTCGTGGCCGCCGGGCTGTGTCCGGGGCCGCGTGAGAAAGCTCTGCGGGACTGAGGGCTGGGTGGGTCGACCGGGAACGGCGCGCG
CTCCCGCCGCCATCGCGCCTCCGTCCCCGCCTGCGGCCTGTCTGGGGGTCGCGGGGCGCAGGCGCGGCGGGCCGACGGGCGGGGGTCCTC
CCCACGGGTGCGCGGGCGCCTTTGTTCCCGGCGCCGAAGCGGGGTGGGGCCTCAGGGCAGCCCCGCCCCGCCGCGCTGAGGCCCCGCCCC
GTGTCCGCCTGCAGGAGCCGCCGCCGGGTCCCGCTCGTCTGCCGCCTCAGCCTCAGCCCCAACCTCAGCCGCCGCCGTTGCGCTTGCTCC
CGGGCGGTCCTGGCCTGTGCCGCCGCCGCCCCCAGCGTCGGAGCCATGGCGGGCGCCGCGTCCCCTTGCGCCAACGGCTGCGGGCCCGGC
GCGCCCTCGGACGCCGAGGTGCTGCACCTCTGCCGCAGCCTCGAGGTGGGCACCGTCATGACTTTGTTCTACTCCAAGAAGTCGCAGCGA
CCCGAGCGGAAGACCTTCCAGGTCAAGCTGGAGACGCGCCAGATCACGTGGAGCCGGGGCGCCGACAAGATCGAGGGGGCCATTGACATT
CGTGAAATTAAGGAGATCCGCCCAGGGAAGACCTCACGGGACTTTGATCGCTATCAAGAGGACCCAGCTTTCCGGCCGGACCAGTCACAT
TGCTTTGTCATTCTCTATGGAATGGAATTTCGCCTGAAAACGCTGAGCCTGCAAGCCACATCTGAGGATGAAGTGAACATGTGGATCAAG
GGCTTAACTTGGCTGATGGAGGATACATTGCAGGCACCCACACCCCTGCAGATTGAGAGGTGGCTCCGGAAGCAGTTTTACTCAGTGGAT
CGGAATCGTGAGGATCGTATATCAGCCAAGGACCTGAAGAACATGCTGTCCCAGGTCAACTACCGGGTCCCCAACATGCGCTTCCTCCGA
GAGCGGCTGACGGACCTGGAGCAGCGCAGCGGGGACATCACCTACGGGCAGTTTGCTCAGCTGTACCGCAGCCTCATGTACAGCGCCCAG
AAGACGATGGACCTCCCCTTCTTGGAAGCCAGTACTCTGAGGGCTGGGGAGCGGCCGGAGCTTTGCCGAGTGTCCCTTCCTGAGTTCCAG
CAGTTCCTTCTTGACTACCAGGGGGAGCTGTGGGCTGTTGATCGCCTCCAGGTGCAGGAGTTCATGCTCAGCTTCCTCCGAGACCCCTTA
CGAGAGATCGAGGAGCCATACTTCTTCCTGGATGAGTTTGTCACCTTCCTGTTCTCCAAAGAGAACAGTGTGTGGAACTCGCAGCTGGAT
GCAGTATGCCCGGACACCATGAACAACCCTCTTTCCCACTACTGGATCTCCTCCTCGCACAACACGTACCTGACCGGGGACCAGTTCTCC
AGTGAGTCCTCCTTGGAAGCCTATGCTCGCTGCCTGCGGATGGGCTGTCGCTGCATTGAGTTGGACTGCTGGGACGGCCCGGATGGGATG
CCAGTTATTTACCATGGGCACACCCTTACCACCAAGATCAAGTTCTCAGATGTCCTGCACACCATCAAGGAGCATGCCTTTGTGGCCTCA
GAGTACCCAGTCATCCTGTCCATTGAGGACCACTGCAGCATTGCCCAGCAGAGAAACATGGCCCAATACTTCAAGAAGGTGCTGGGGGAC
ACACTCCTCACCAAGCCCGTGGAGATCTCTGCCGACGGGCTCCCCTCACCCAACCAGCTTAAGAGGAAGATCCTCATCAAGCACAAGAAG
CTGGCTGAGGGCAGTGCCTACGAGGAGGTGCCTACATCCATGATGTACTCTGAGAACGACATCAGCAACTCTATCAAGAATGGCATCCTC
TACCTGGAGGACCCTGTGAACCACGAATGGTATCCCCACTACTTTGTTCTGACCAGCAGCAAGATCTACTACTCTGAGGAGACCAGCAGT
GACCAGGGCAACGAGGATGAGGAGGAGCCCAAGGAGGTCAGCAGCAGCACAGAGCTGCACTCCAATGAGAAGTGGTTCCATGGGAAGCTA
GGGGCAGGGCGTGACGGGCGTCACATCGCTGAGCGCCTGCTTACTGAGTACTGCATCGAGACCGGAGCCCCTGACGGCTCCTTCCTCGTG
CGAGAGAGTGAGACCTTCGTGGGCGACTACACGCTCTCTTTCTGGCGGAACGGGAAAGTCCAGCACTGCCGTATCCACTCCCGGCAAGAT
GCTGGGACCCCCAAGTTCTTCTTGACAGACAACCTCGTCTTTGACTCCCTCTATGACCTCATCACGCACTACCAGCAGGTGCCCCTGCGC
TGTAATGAGTTTGAGATGCGACTTTCAGAGCCTGTCCCACAGACCAACGCCCACGAGAGCAAAGAGTGGTACCACGCGAGCCTGACCAGA
GCACAGGCTGAGCACATGCTAATGCGCGTCCCTCGTGATGGGGCCTTCCTGGTGCGGAAGCGGAATGAACCCAACTCATATGCCATCTCT
TTCCGGGCTGAGGGCAAGATCAAGCATTGCCGTGTCCAGCAAGAGGGCCAGACAGTGATGCTAGGGAACTCGGAGTTCGACAGCCTTGTT
GACCTCATCAGCTACTATGAGAAACACCCGCTATACCGCAAGATGAAGCTGCGCTATCCCATCAACGAGGAGGCACTGGAGAAGATTGGC
ACAGCTGAGCCTGACTACGGGGCCCTGTATGAGGGACGCAACCCTGGCTTCTATGTAGAGGCAAACCCTATGCCAACTTTCAAGTGTGCA
GTCAAAGCCCTCTTTGACTACAAGGCCCAGAGGGAGGACGAGCTGACCTTCATCAAGAGCGCCATCATCCAGAATGTGGAGAAGCAAGAG
GGAGGCTGGTGGCGAGGGGACTACGGAGGGAAGAAGCAGCTGTGGTTCCCATCAAACTACGTGGAAGAGATGGTCAACCCCGTGGCCCTG
GAGCCGGAGAGGGAGCACTTGGACGAGAACAGCCCCCTAGGGGACTTGCTGCGGGGGGTCTTGGATGTGCCGGCTTGTCAGATTGCCATC
CGTCCTGAGGGCAAGAACAACCGGCTCTTCGTCTTCTCCATCAGCATGGCGTCGGTGGCCCACTGGTCCCTGGATGTTGCTGCCGACTCA
CAGGAGGAGCTGCAGGACTGGGTGAAAAAGATCCGTGAAGTGGCCCAGACAGCAGACGCCAGGGATTGTGACCAGATCCACGTTGATGAC
GTCTCATCAGATGACAATGGCCAAGATTTAAGCACATACAACTTCTCCGCTGACGGCTTCCACAGTTCGGCCCCAGGAGCCAACCTGTGC
CTGGGCTCTGGCGTGCACGGCGGCGTGGACTGGATGAGGAAGCTGGCCTTCCGCTACCGGCGGGTGAAGGAGATGTACAATACCTACAAG
AACAACGTTGGTGGGTTGATAGGCACTCCCAAAAGGGAGACCTGGCTACAGCTCCGAGCTGAGCTGGAAGCTCTCACAGACCTCTGGCTG
ACCCACTCCCTGAAGGCACTAAACCTCATCAACTCCCGGCCCAACTGTGTCAATGTGCTGGTCACCACCACTCAACTAATTCCTGCCCTG
GCCAAAGTCCTGCTATATGGCCTGGGGTCTGTGTTTCCTATTGAGAACATCTACAGTGCAACCAAGACAGGGAAGGAGAGCTGCTTCGAG
AGGATAATGCAGAGATTCGGCAGAAAAGCTGTCTACGTGGTGATCGGTGATGGTGTGGAAGAGGAGCAAGGAGCGAAAAAGCACAACATG
CCTTTCTGGCGGATATCCTGCCACGCAGACCTGGAGGCACTGAGGCACGCCCTGGAGCTGGAGTATTTATAGCAGGATCAGCAGCATCTC
CACCTGCCATCTCACCCTCAGACCCCCTCGCCTTCCCCACCTCCCCACCGAGAACTCCAGAGACCCAGATGTTGGACACCAGGAAGGGGC
CCCACAGCCGAGACGACGTGTCCAGTGACCATCTCAGAAGCCGTCCATCAGTCCAAATGGGGGTTCTGAGAAGGAAAGTACCCAACATTG
GCTTCGGAGTATTTGACTTTGGGGAAAAGGGCTGGCTCGGAGTCTAGACTCTTCTGTAAGACTCACAGAACAAAAGCAAGGAATTGCTGA
TTTGGGGGGTGCCTGGTGATGAGGAGGGGATGGGTTTGTCTTGTCTTCTTTTTAATTTATGGACTAGTCTCATTACTCCGGAATTATGCT
CTTGTACCTGTGTGGCTGGGTTTCTTAGTCGTTGGTTTGGTTTGGTTTTTTGAACTGGTATGTGGGGTGGTTCACAGTTCTAATGTAAGC
ACTCTATTCTCCAAGTTGTGCTTTGTGGGGACAATCATTCTTTGAACATTAGAGAGGAAGGCAGTTCAAGCTGTTGAAAAGACTATTGCT
TATTTTTGTTTTTAAAGACCTACTTGACGTCATGTGGACAGTGCACGTGCCTTACGCTACATCTTGTTTTCTAGGAAGAGGGGGATGCTG

>66023_66023_5_PLCG1-EYA2_PLCG1_chr20_39798909_ENST00000373271_EYA2_chr20_45797786_ENST00000327619_length(amino acids)=1265AA_BP=1053
MRAGWVDRERRALPPPSRLRPRLRPVWGSRGAGAAGRRAGVLPTGARAPLFPAPKRGGASGQPRPAALRPRPVSACRSRRRVPLVCRLSL
SPNLSRRRCACSRAVLACAAAAPSVGAMAGAASPCANGCGPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQITWS
RGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWIKGLTWLMEDTLQAPTPLQI
ERWLRKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRAGER
PELCRVSLPEFQQFLLDYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVTFLFSKENSVWNSQLDAVCPDTMNNPLSHYWISS
SHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQR
NMAQYFKKVLGDTLLTKPVEISADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSMMYSENDISNSIKNGILYLEDPVNHEWYPHYFVLT
SSKIYYSEETSSDQGNEDEEEPKEVSSSTELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFWRNG
KVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQTNAHESKEWYHASLTRAQAEHMLMRVPRDGAFLV
RKRNEPNSYAISFRAEGKIKHCRVQQEGQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNPGFY
VEANPMPTFKCAVKALFDYKAQREDELTFIKSAIIQNVEKQEGGWWRGDYGGKKQLWFPSNYVEEMVNPVALEPEREHLDENSPLGDLLR
GVLDVPACQIAIRPEGKNNRLFVFSISMASVAHWSLDVAADSQEELQDWVKKIREVAQTADARDCDQIHVDDVSSDDNGQDLSTYNFSAD
GFHSSAPGANLCLGSGVHGGVDWMRKLAFRYRRVKEMYNTYKNNVGGLIGTPKRETWLQLRAELEALTDLWLTHSLKALNLINSRPNCVN
VLVTTTQLIPALAKVLLYGLGSVFPIENIYSATKTGKESCFERIMQRFGRKAVYVVIGDGVEEEQGAKKHNMPFWRISCHADLEALRHAL

--------------------------------------------------------------
>66023_66023_6_PLCG1-EYA2_PLCG1_chr20_39798909_ENST00000373271_EYA2_chr20_45797786_ENST00000357410_length(transcript)=4326nt_BP=3213nt
GCCGCTCGTGGCCGCCGGGCTGTGTCCGGGGCCGCGTGAGAAAGCTCTGCGGGACTGAGGGCTGGGTGGGTCGACCGGGAACGGCGCGCG
CTCCCGCCGCCATCGCGCCTCCGTCCCCGCCTGCGGCCTGTCTGGGGGTCGCGGGGCGCAGGCGCGGCGGGCCGACGGGCGGGGGTCCTC
CCCACGGGTGCGCGGGCGCCTTTGTTCCCGGCGCCGAAGCGGGGTGGGGCCTCAGGGCAGCCCCGCCCCGCCGCGCTGAGGCCCCGCCCC
GTGTCCGCCTGCAGGAGCCGCCGCCGGGTCCCGCTCGTCTGCCGCCTCAGCCTCAGCCCCAACCTCAGCCGCCGCCGTTGCGCTTGCTCC
CGGGCGGTCCTGGCCTGTGCCGCCGCCGCCCCCAGCGTCGGAGCCATGGCGGGCGCCGCGTCCCCTTGCGCCAACGGCTGCGGGCCCGGC
GCGCCCTCGGACGCCGAGGTGCTGCACCTCTGCCGCAGCCTCGAGGTGGGCACCGTCATGACTTTGTTCTACTCCAAGAAGTCGCAGCGA
CCCGAGCGGAAGACCTTCCAGGTCAAGCTGGAGACGCGCCAGATCACGTGGAGCCGGGGCGCCGACAAGATCGAGGGGGCCATTGACATT
CGTGAAATTAAGGAGATCCGCCCAGGGAAGACCTCACGGGACTTTGATCGCTATCAAGAGGACCCAGCTTTCCGGCCGGACCAGTCACAT
TGCTTTGTCATTCTCTATGGAATGGAATTTCGCCTGAAAACGCTGAGCCTGCAAGCCACATCTGAGGATGAAGTGAACATGTGGATCAAG
GGCTTAACTTGGCTGATGGAGGATACATTGCAGGCACCCACACCCCTGCAGATTGAGAGGTGGCTCCGGAAGCAGTTTTACTCAGTGGAT
CGGAATCGTGAGGATCGTATATCAGCCAAGGACCTGAAGAACATGCTGTCCCAGGTCAACTACCGGGTCCCCAACATGCGCTTCCTCCGA
GAGCGGCTGACGGACCTGGAGCAGCGCAGCGGGGACATCACCTACGGGCAGTTTGCTCAGCTGTACCGCAGCCTCATGTACAGCGCCCAG
AAGACGATGGACCTCCCCTTCTTGGAAGCCAGTACTCTGAGGGCTGGGGAGCGGCCGGAGCTTTGCCGAGTGTCCCTTCCTGAGTTCCAG
CAGTTCCTTCTTGACTACCAGGGGGAGCTGTGGGCTGTTGATCGCCTCCAGGTGCAGGAGTTCATGCTCAGCTTCCTCCGAGACCCCTTA
CGAGAGATCGAGGAGCCATACTTCTTCCTGGATGAGTTTGTCACCTTCCTGTTCTCCAAAGAGAACAGTGTGTGGAACTCGCAGCTGGAT
GCAGTATGCCCGGACACCATGAACAACCCTCTTTCCCACTACTGGATCTCCTCCTCGCACAACACGTACCTGACCGGGGACCAGTTCTCC
AGTGAGTCCTCCTTGGAAGCCTATGCTCGCTGCCTGCGGATGGGCTGTCGCTGCATTGAGTTGGACTGCTGGGACGGCCCGGATGGGATG
CCAGTTATTTACCATGGGCACACCCTTACCACCAAGATCAAGTTCTCAGATGTCCTGCACACCATCAAGGAGCATGCCTTTGTGGCCTCA
GAGTACCCAGTCATCCTGTCCATTGAGGACCACTGCAGCATTGCCCAGCAGAGAAACATGGCCCAATACTTCAAGAAGGTGCTGGGGGAC
ACACTCCTCACCAAGCCCGTGGAGATCTCTGCCGACGGGCTCCCCTCACCCAACCAGCTTAAGAGGAAGATCCTCATCAAGCACAAGAAG
CTGGCTGAGGGCAGTGCCTACGAGGAGGTGCCTACATCCATGATGTACTCTGAGAACGACATCAGCAACTCTATCAAGAATGGCATCCTC
TACCTGGAGGACCCTGTGAACCACGAATGGTATCCCCACTACTTTGTTCTGACCAGCAGCAAGATCTACTACTCTGAGGAGACCAGCAGT
GACCAGGGCAACGAGGATGAGGAGGAGCCCAAGGAGGTCAGCAGCAGCACAGAGCTGCACTCCAATGAGAAGTGGTTCCATGGGAAGCTA
GGGGCAGGGCGTGACGGGCGTCACATCGCTGAGCGCCTGCTTACTGAGTACTGCATCGAGACCGGAGCCCCTGACGGCTCCTTCCTCGTG
CGAGAGAGTGAGACCTTCGTGGGCGACTACACGCTCTCTTTCTGGCGGAACGGGAAAGTCCAGCACTGCCGTATCCACTCCCGGCAAGAT
GCTGGGACCCCCAAGTTCTTCTTGACAGACAACCTCGTCTTTGACTCCCTCTATGACCTCATCACGCACTACCAGCAGGTGCCCCTGCGC
TGTAATGAGTTTGAGATGCGACTTTCAGAGCCTGTCCCACAGACCAACGCCCACGAGAGCAAAGAGTGGTACCACGCGAGCCTGACCAGA
GCACAGGCTGAGCACATGCTAATGCGCGTCCCTCGTGATGGGGCCTTCCTGGTGCGGAAGCGGAATGAACCCAACTCATATGCCATCTCT
TTCCGGGCTGAGGGCAAGATCAAGCATTGCCGTGTCCAGCAAGAGGGCCAGACAGTGATGCTAGGGAACTCGGAGTTCGACAGCCTTGTT
GACCTCATCAGCTACTATGAGAAACACCCGCTATACCGCAAGATGAAGCTGCGCTATCCCATCAACGAGGAGGCACTGGAGAAGATTGGC
ACAGCTGAGCCTGACTACGGGGCCCTGTATGAGGGACGCAACCCTGGCTTCTATGTAGAGGCAAACCCTATGCCAACTTTCAAGTGTGCA
GTCAAAGCCCTCTTTGACTACAAGGCCCAGAGGGAGGACGAGCTGACCTTCATCAAGAGCGCCATCATCCAGAATGTGGAGAAGCAAGAG
GGAGGCTGGTGGCGAGGGGACTACGGAGGGAAGAAGCAGCTGTGGTTCCCATCAAACTACGTGGAAGAGATGGTCAACCCCGTGGCCCTG
GAGCCGGAGAGGGAGCACTTGGACGAGAACAGCCCCCTAGGGGACTTGCTGCGGGGGGTCTTGGATGTGCCGGCTTGTCAGATTGCCATC
CGTCCTGAGGGCAAGAACAACCGGCTCTTCGTCTTCTCCATCAGCATGGCGTCGGTGGCCCACTGGTCCCTGGATGTTGCTGCCGACTCA
CAGGAGGAGCTGCAGGACTGGGTGAAAAAGATCCGTGAAGTGGCCCAGACAGCAGACGCCAGGGATTGTGACCAGATCCACGTTGATGAC
GTCTCATCAGATGACAATGGCCAAGATTTAAGCACATACAACTTCTCCGCTGACGGCTTCCACAGTTCGGCCCCAGGAGCCAACCTGTGC
CTGGGCTCTGGCGTGCACGGCGGCGTGGACTGGATGAGGAAGCTGGCCTTCCGCTACCGGCGGGTGAAGGAGATGTACAATACCTACAAG
AACAACGTTGGTGGGAAGGAGAGCTGCTTCGAGAGGATAATGCAGAGATTCGGCAGAAAAGCTGTCTACGTGGTGATCGGTGATGGTGTG
GAAGAGGAGCAAGGAGCGAAAAAGCACAACATGCCTTTCTGGCGGATATCCTGCCACGCAGACCTGGAGGCACTGAGGCACGCCCTGGAG
CTGGAGTATTTATAGCAGGATCAGCAGCATCTCCACCTGCCATCTCACCCTCAGACCCCCTCGCCTTCCCCACCTCCCCACCGAGAACTC
CAGAGACCCAGATGTTGGACACCAGGAAGGGGCCCCACAGCCGAGACGACGTGTCCAGTGACCATCTCAGAAGCCGTCCATCAGTCCAAA
TGGGGGTTCTGAGAAGGAAAGTACCCAACATTGGCTTCGGAGTATTTGACTTTGGGGAAAAGGGCTGGCTCGGAGTCTAGACTCTTCTGT
AAGACTCACAGAACAAAAGCAAGGAATTGCTGATTTGGGGGGTGCCTGGTGATGAGGAGGGGATGGGTTTGTCTTGTCTTCTTTTTAATT
TATGGACTAGTCTCATTACTCCGGAATTATGCTCTTGTACCTGTGTGGCTGGGTTTCTTAGTCGTTGGTTTGGTTTGGTTTTTTGAACTG
GTATGTGGGGTGGTTCACAGTTCTAATGTAAGCACTCTATTCTCCAAGTTGTGCTTTGTGGGGACAATCATTCTTTGAACATTAGAGAGG
AAGGCAGTTCAAGCTGTTGAAAAGACTATTGCTTATTTTTGTTTTTAAAGACCTACTTGACGTCATGTGGACAGTGCACGTGCCTTACGC
TACATCTTGTTTTCTAGGAAGAGGGGGATGCTGGGAAGGAATGGGTGCTTTGTGATGGATAAAAGGCATTAAATAAAACCACGTTTACAT

>66023_66023_6_PLCG1-EYA2_PLCG1_chr20_39798909_ENST00000373271_EYA2_chr20_45797786_ENST00000357410_length(amino acids)=1186AA_BP=1053
MRAGWVDRERRALPPPSRLRPRLRPVWGSRGAGAAGRRAGVLPTGARAPLFPAPKRGGASGQPRPAALRPRPVSACRSRRRVPLVCRLSL
SPNLSRRRCACSRAVLACAAAAPSVGAMAGAASPCANGCGPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQITWS
RGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWIKGLTWLMEDTLQAPTPLQI
ERWLRKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRAGER
PELCRVSLPEFQQFLLDYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVTFLFSKENSVWNSQLDAVCPDTMNNPLSHYWISS
SHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQR
NMAQYFKKVLGDTLLTKPVEISADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSMMYSENDISNSIKNGILYLEDPVNHEWYPHYFVLT
SSKIYYSEETSSDQGNEDEEEPKEVSSSTELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFWRNG
KVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQTNAHESKEWYHASLTRAQAEHMLMRVPRDGAFLV
RKRNEPNSYAISFRAEGKIKHCRVQQEGQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNPGFY
VEANPMPTFKCAVKALFDYKAQREDELTFIKSAIIQNVEKQEGGWWRGDYGGKKQLWFPSNYVEEMVNPVALEPEREHLDENSPLGDLLR
GVLDVPACQIAIRPEGKNNRLFVFSISMASVAHWSLDVAADSQEELQDWVKKIREVAQTADARDCDQIHVDDVSSDDNGQDLSTYNFSAD
GFHSSAPGANLCLGSGVHGGVDWMRKLAFRYRRVKEMYNTYKNNVGGKESCFERIMQRFGRKAVYVVIGDGVEEEQGAKKHNMPFWRISC

--------------------------------------------------------------
>66023_66023_7_PLCG1-EYA2_PLCG1_chr20_39798909_ENST00000373271_EYA2_chr20_45797787_ENST00000327619_length(transcript)=4563nt_BP=3213nt
GCCGCTCGTGGCCGCCGGGCTGTGTCCGGGGCCGCGTGAGAAAGCTCTGCGGGACTGAGGGCTGGGTGGGTCGACCGGGAACGGCGCGCG
CTCCCGCCGCCATCGCGCCTCCGTCCCCGCCTGCGGCCTGTCTGGGGGTCGCGGGGCGCAGGCGCGGCGGGCCGACGGGCGGGGGTCCTC
CCCACGGGTGCGCGGGCGCCTTTGTTCCCGGCGCCGAAGCGGGGTGGGGCCTCAGGGCAGCCCCGCCCCGCCGCGCTGAGGCCCCGCCCC
GTGTCCGCCTGCAGGAGCCGCCGCCGGGTCCCGCTCGTCTGCCGCCTCAGCCTCAGCCCCAACCTCAGCCGCCGCCGTTGCGCTTGCTCC
CGGGCGGTCCTGGCCTGTGCCGCCGCCGCCCCCAGCGTCGGAGCCATGGCGGGCGCCGCGTCCCCTTGCGCCAACGGCTGCGGGCCCGGC
GCGCCCTCGGACGCCGAGGTGCTGCACCTCTGCCGCAGCCTCGAGGTGGGCACCGTCATGACTTTGTTCTACTCCAAGAAGTCGCAGCGA
CCCGAGCGGAAGACCTTCCAGGTCAAGCTGGAGACGCGCCAGATCACGTGGAGCCGGGGCGCCGACAAGATCGAGGGGGCCATTGACATT
CGTGAAATTAAGGAGATCCGCCCAGGGAAGACCTCACGGGACTTTGATCGCTATCAAGAGGACCCAGCTTTCCGGCCGGACCAGTCACAT
TGCTTTGTCATTCTCTATGGAATGGAATTTCGCCTGAAAACGCTGAGCCTGCAAGCCACATCTGAGGATGAAGTGAACATGTGGATCAAG
GGCTTAACTTGGCTGATGGAGGATACATTGCAGGCACCCACACCCCTGCAGATTGAGAGGTGGCTCCGGAAGCAGTTTTACTCAGTGGAT
CGGAATCGTGAGGATCGTATATCAGCCAAGGACCTGAAGAACATGCTGTCCCAGGTCAACTACCGGGTCCCCAACATGCGCTTCCTCCGA
GAGCGGCTGACGGACCTGGAGCAGCGCAGCGGGGACATCACCTACGGGCAGTTTGCTCAGCTGTACCGCAGCCTCATGTACAGCGCCCAG
AAGACGATGGACCTCCCCTTCTTGGAAGCCAGTACTCTGAGGGCTGGGGAGCGGCCGGAGCTTTGCCGAGTGTCCCTTCCTGAGTTCCAG
CAGTTCCTTCTTGACTACCAGGGGGAGCTGTGGGCTGTTGATCGCCTCCAGGTGCAGGAGTTCATGCTCAGCTTCCTCCGAGACCCCTTA
CGAGAGATCGAGGAGCCATACTTCTTCCTGGATGAGTTTGTCACCTTCCTGTTCTCCAAAGAGAACAGTGTGTGGAACTCGCAGCTGGAT
GCAGTATGCCCGGACACCATGAACAACCCTCTTTCCCACTACTGGATCTCCTCCTCGCACAACACGTACCTGACCGGGGACCAGTTCTCC
AGTGAGTCCTCCTTGGAAGCCTATGCTCGCTGCCTGCGGATGGGCTGTCGCTGCATTGAGTTGGACTGCTGGGACGGCCCGGATGGGATG
CCAGTTATTTACCATGGGCACACCCTTACCACCAAGATCAAGTTCTCAGATGTCCTGCACACCATCAAGGAGCATGCCTTTGTGGCCTCA
GAGTACCCAGTCATCCTGTCCATTGAGGACCACTGCAGCATTGCCCAGCAGAGAAACATGGCCCAATACTTCAAGAAGGTGCTGGGGGAC
ACACTCCTCACCAAGCCCGTGGAGATCTCTGCCGACGGGCTCCCCTCACCCAACCAGCTTAAGAGGAAGATCCTCATCAAGCACAAGAAG
CTGGCTGAGGGCAGTGCCTACGAGGAGGTGCCTACATCCATGATGTACTCTGAGAACGACATCAGCAACTCTATCAAGAATGGCATCCTC
TACCTGGAGGACCCTGTGAACCACGAATGGTATCCCCACTACTTTGTTCTGACCAGCAGCAAGATCTACTACTCTGAGGAGACCAGCAGT
GACCAGGGCAACGAGGATGAGGAGGAGCCCAAGGAGGTCAGCAGCAGCACAGAGCTGCACTCCAATGAGAAGTGGTTCCATGGGAAGCTA
GGGGCAGGGCGTGACGGGCGTCACATCGCTGAGCGCCTGCTTACTGAGTACTGCATCGAGACCGGAGCCCCTGACGGCTCCTTCCTCGTG
CGAGAGAGTGAGACCTTCGTGGGCGACTACACGCTCTCTTTCTGGCGGAACGGGAAAGTCCAGCACTGCCGTATCCACTCCCGGCAAGAT
GCTGGGACCCCCAAGTTCTTCTTGACAGACAACCTCGTCTTTGACTCCCTCTATGACCTCATCACGCACTACCAGCAGGTGCCCCTGCGC
TGTAATGAGTTTGAGATGCGACTTTCAGAGCCTGTCCCACAGACCAACGCCCACGAGAGCAAAGAGTGGTACCACGCGAGCCTGACCAGA
GCACAGGCTGAGCACATGCTAATGCGCGTCCCTCGTGATGGGGCCTTCCTGGTGCGGAAGCGGAATGAACCCAACTCATATGCCATCTCT
TTCCGGGCTGAGGGCAAGATCAAGCATTGCCGTGTCCAGCAAGAGGGCCAGACAGTGATGCTAGGGAACTCGGAGTTCGACAGCCTTGTT
GACCTCATCAGCTACTATGAGAAACACCCGCTATACCGCAAGATGAAGCTGCGCTATCCCATCAACGAGGAGGCACTGGAGAAGATTGGC
ACAGCTGAGCCTGACTACGGGGCCCTGTATGAGGGACGCAACCCTGGCTTCTATGTAGAGGCAAACCCTATGCCAACTTTCAAGTGTGCA
GTCAAAGCCCTCTTTGACTACAAGGCCCAGAGGGAGGACGAGCTGACCTTCATCAAGAGCGCCATCATCCAGAATGTGGAGAAGCAAGAG
GGAGGCTGGTGGCGAGGGGACTACGGAGGGAAGAAGCAGCTGTGGTTCCCATCAAACTACGTGGAAGAGATGGTCAACCCCGTGGCCCTG
GAGCCGGAGAGGGAGCACTTGGACGAGAACAGCCCCCTAGGGGACTTGCTGCGGGGGGTCTTGGATGTGCCGGCTTGTCAGATTGCCATC
CGTCCTGAGGGCAAGAACAACCGGCTCTTCGTCTTCTCCATCAGCATGGCGTCGGTGGCCCACTGGTCCCTGGATGTTGCTGCCGACTCA
CAGGAGGAGCTGCAGGACTGGGTGAAAAAGATCCGTGAAGTGGCCCAGACAGCAGACGCCAGGGATTGTGACCAGATCCACGTTGATGAC
GTCTCATCAGATGACAATGGCCAAGATTTAAGCACATACAACTTCTCCGCTGACGGCTTCCACAGTTCGGCCCCAGGAGCCAACCTGTGC
CTGGGCTCTGGCGTGCACGGCGGCGTGGACTGGATGAGGAAGCTGGCCTTCCGCTACCGGCGGGTGAAGGAGATGTACAATACCTACAAG
AACAACGTTGGTGGGTTGATAGGCACTCCCAAAAGGGAGACCTGGCTACAGCTCCGAGCTGAGCTGGAAGCTCTCACAGACCTCTGGCTG
ACCCACTCCCTGAAGGCACTAAACCTCATCAACTCCCGGCCCAACTGTGTCAATGTGCTGGTCACCACCACTCAACTAATTCCTGCCCTG
GCCAAAGTCCTGCTATATGGCCTGGGGTCTGTGTTTCCTATTGAGAACATCTACAGTGCAACCAAGACAGGGAAGGAGAGCTGCTTCGAG
AGGATAATGCAGAGATTCGGCAGAAAAGCTGTCTACGTGGTGATCGGTGATGGTGTGGAAGAGGAGCAAGGAGCGAAAAAGCACAACATG
CCTTTCTGGCGGATATCCTGCCACGCAGACCTGGAGGCACTGAGGCACGCCCTGGAGCTGGAGTATTTATAGCAGGATCAGCAGCATCTC
CACCTGCCATCTCACCCTCAGACCCCCTCGCCTTCCCCACCTCCCCACCGAGAACTCCAGAGACCCAGATGTTGGACACCAGGAAGGGGC
CCCACAGCCGAGACGACGTGTCCAGTGACCATCTCAGAAGCCGTCCATCAGTCCAAATGGGGGTTCTGAGAAGGAAAGTACCCAACATTG
GCTTCGGAGTATTTGACTTTGGGGAAAAGGGCTGGCTCGGAGTCTAGACTCTTCTGTAAGACTCACAGAACAAAAGCAAGGAATTGCTGA
TTTGGGGGGTGCCTGGTGATGAGGAGGGGATGGGTTTGTCTTGTCTTCTTTTTAATTTATGGACTAGTCTCATTACTCCGGAATTATGCT
CTTGTACCTGTGTGGCTGGGTTTCTTAGTCGTTGGTTTGGTTTGGTTTTTTGAACTGGTATGTGGGGTGGTTCACAGTTCTAATGTAAGC
ACTCTATTCTCCAAGTTGTGCTTTGTGGGGACAATCATTCTTTGAACATTAGAGAGGAAGGCAGTTCAAGCTGTTGAAAAGACTATTGCT
TATTTTTGTTTTTAAAGACCTACTTGACGTCATGTGGACAGTGCACGTGCCTTACGCTACATCTTGTTTTCTAGGAAGAGGGGGATGCTG

>66023_66023_7_PLCG1-EYA2_PLCG1_chr20_39798909_ENST00000373271_EYA2_chr20_45797787_ENST00000327619_length(amino acids)=1265AA_BP=1053
MRAGWVDRERRALPPPSRLRPRLRPVWGSRGAGAAGRRAGVLPTGARAPLFPAPKRGGASGQPRPAALRPRPVSACRSRRRVPLVCRLSL
SPNLSRRRCACSRAVLACAAAAPSVGAMAGAASPCANGCGPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQITWS
RGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWIKGLTWLMEDTLQAPTPLQI
ERWLRKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRAGER
PELCRVSLPEFQQFLLDYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVTFLFSKENSVWNSQLDAVCPDTMNNPLSHYWISS
SHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQR
NMAQYFKKVLGDTLLTKPVEISADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSMMYSENDISNSIKNGILYLEDPVNHEWYPHYFVLT
SSKIYYSEETSSDQGNEDEEEPKEVSSSTELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFWRNG
KVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQTNAHESKEWYHASLTRAQAEHMLMRVPRDGAFLV
RKRNEPNSYAISFRAEGKIKHCRVQQEGQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNPGFY
VEANPMPTFKCAVKALFDYKAQREDELTFIKSAIIQNVEKQEGGWWRGDYGGKKQLWFPSNYVEEMVNPVALEPEREHLDENSPLGDLLR
GVLDVPACQIAIRPEGKNNRLFVFSISMASVAHWSLDVAADSQEELQDWVKKIREVAQTADARDCDQIHVDDVSSDDNGQDLSTYNFSAD
GFHSSAPGANLCLGSGVHGGVDWMRKLAFRYRRVKEMYNTYKNNVGGLIGTPKRETWLQLRAELEALTDLWLTHSLKALNLINSRPNCVN
VLVTTTQLIPALAKVLLYGLGSVFPIENIYSATKTGKESCFERIMQRFGRKAVYVVIGDGVEEEQGAKKHNMPFWRISCHADLEALRHAL

--------------------------------------------------------------
>66023_66023_8_PLCG1-EYA2_PLCG1_chr20_39798909_ENST00000373271_EYA2_chr20_45797787_ENST00000357410_length(transcript)=4326nt_BP=3213nt
GCCGCTCGTGGCCGCCGGGCTGTGTCCGGGGCCGCGTGAGAAAGCTCTGCGGGACTGAGGGCTGGGTGGGTCGACCGGGAACGGCGCGCG
CTCCCGCCGCCATCGCGCCTCCGTCCCCGCCTGCGGCCTGTCTGGGGGTCGCGGGGCGCAGGCGCGGCGGGCCGACGGGCGGGGGTCCTC
CCCACGGGTGCGCGGGCGCCTTTGTTCCCGGCGCCGAAGCGGGGTGGGGCCTCAGGGCAGCCCCGCCCCGCCGCGCTGAGGCCCCGCCCC
GTGTCCGCCTGCAGGAGCCGCCGCCGGGTCCCGCTCGTCTGCCGCCTCAGCCTCAGCCCCAACCTCAGCCGCCGCCGTTGCGCTTGCTCC
CGGGCGGTCCTGGCCTGTGCCGCCGCCGCCCCCAGCGTCGGAGCCATGGCGGGCGCCGCGTCCCCTTGCGCCAACGGCTGCGGGCCCGGC
GCGCCCTCGGACGCCGAGGTGCTGCACCTCTGCCGCAGCCTCGAGGTGGGCACCGTCATGACTTTGTTCTACTCCAAGAAGTCGCAGCGA
CCCGAGCGGAAGACCTTCCAGGTCAAGCTGGAGACGCGCCAGATCACGTGGAGCCGGGGCGCCGACAAGATCGAGGGGGCCATTGACATT
CGTGAAATTAAGGAGATCCGCCCAGGGAAGACCTCACGGGACTTTGATCGCTATCAAGAGGACCCAGCTTTCCGGCCGGACCAGTCACAT
TGCTTTGTCATTCTCTATGGAATGGAATTTCGCCTGAAAACGCTGAGCCTGCAAGCCACATCTGAGGATGAAGTGAACATGTGGATCAAG
GGCTTAACTTGGCTGATGGAGGATACATTGCAGGCACCCACACCCCTGCAGATTGAGAGGTGGCTCCGGAAGCAGTTTTACTCAGTGGAT
CGGAATCGTGAGGATCGTATATCAGCCAAGGACCTGAAGAACATGCTGTCCCAGGTCAACTACCGGGTCCCCAACATGCGCTTCCTCCGA
GAGCGGCTGACGGACCTGGAGCAGCGCAGCGGGGACATCACCTACGGGCAGTTTGCTCAGCTGTACCGCAGCCTCATGTACAGCGCCCAG
AAGACGATGGACCTCCCCTTCTTGGAAGCCAGTACTCTGAGGGCTGGGGAGCGGCCGGAGCTTTGCCGAGTGTCCCTTCCTGAGTTCCAG
CAGTTCCTTCTTGACTACCAGGGGGAGCTGTGGGCTGTTGATCGCCTCCAGGTGCAGGAGTTCATGCTCAGCTTCCTCCGAGACCCCTTA
CGAGAGATCGAGGAGCCATACTTCTTCCTGGATGAGTTTGTCACCTTCCTGTTCTCCAAAGAGAACAGTGTGTGGAACTCGCAGCTGGAT
GCAGTATGCCCGGACACCATGAACAACCCTCTTTCCCACTACTGGATCTCCTCCTCGCACAACACGTACCTGACCGGGGACCAGTTCTCC
AGTGAGTCCTCCTTGGAAGCCTATGCTCGCTGCCTGCGGATGGGCTGTCGCTGCATTGAGTTGGACTGCTGGGACGGCCCGGATGGGATG
CCAGTTATTTACCATGGGCACACCCTTACCACCAAGATCAAGTTCTCAGATGTCCTGCACACCATCAAGGAGCATGCCTTTGTGGCCTCA
GAGTACCCAGTCATCCTGTCCATTGAGGACCACTGCAGCATTGCCCAGCAGAGAAACATGGCCCAATACTTCAAGAAGGTGCTGGGGGAC
ACACTCCTCACCAAGCCCGTGGAGATCTCTGCCGACGGGCTCCCCTCACCCAACCAGCTTAAGAGGAAGATCCTCATCAAGCACAAGAAG
CTGGCTGAGGGCAGTGCCTACGAGGAGGTGCCTACATCCATGATGTACTCTGAGAACGACATCAGCAACTCTATCAAGAATGGCATCCTC
TACCTGGAGGACCCTGTGAACCACGAATGGTATCCCCACTACTTTGTTCTGACCAGCAGCAAGATCTACTACTCTGAGGAGACCAGCAGT
GACCAGGGCAACGAGGATGAGGAGGAGCCCAAGGAGGTCAGCAGCAGCACAGAGCTGCACTCCAATGAGAAGTGGTTCCATGGGAAGCTA
GGGGCAGGGCGTGACGGGCGTCACATCGCTGAGCGCCTGCTTACTGAGTACTGCATCGAGACCGGAGCCCCTGACGGCTCCTTCCTCGTG
CGAGAGAGTGAGACCTTCGTGGGCGACTACACGCTCTCTTTCTGGCGGAACGGGAAAGTCCAGCACTGCCGTATCCACTCCCGGCAAGAT
GCTGGGACCCCCAAGTTCTTCTTGACAGACAACCTCGTCTTTGACTCCCTCTATGACCTCATCACGCACTACCAGCAGGTGCCCCTGCGC
TGTAATGAGTTTGAGATGCGACTTTCAGAGCCTGTCCCACAGACCAACGCCCACGAGAGCAAAGAGTGGTACCACGCGAGCCTGACCAGA
GCACAGGCTGAGCACATGCTAATGCGCGTCCCTCGTGATGGGGCCTTCCTGGTGCGGAAGCGGAATGAACCCAACTCATATGCCATCTCT
TTCCGGGCTGAGGGCAAGATCAAGCATTGCCGTGTCCAGCAAGAGGGCCAGACAGTGATGCTAGGGAACTCGGAGTTCGACAGCCTTGTT
GACCTCATCAGCTACTATGAGAAACACCCGCTATACCGCAAGATGAAGCTGCGCTATCCCATCAACGAGGAGGCACTGGAGAAGATTGGC
ACAGCTGAGCCTGACTACGGGGCCCTGTATGAGGGACGCAACCCTGGCTTCTATGTAGAGGCAAACCCTATGCCAACTTTCAAGTGTGCA
GTCAAAGCCCTCTTTGACTACAAGGCCCAGAGGGAGGACGAGCTGACCTTCATCAAGAGCGCCATCATCCAGAATGTGGAGAAGCAAGAG
GGAGGCTGGTGGCGAGGGGACTACGGAGGGAAGAAGCAGCTGTGGTTCCCATCAAACTACGTGGAAGAGATGGTCAACCCCGTGGCCCTG
GAGCCGGAGAGGGAGCACTTGGACGAGAACAGCCCCCTAGGGGACTTGCTGCGGGGGGTCTTGGATGTGCCGGCTTGTCAGATTGCCATC
CGTCCTGAGGGCAAGAACAACCGGCTCTTCGTCTTCTCCATCAGCATGGCGTCGGTGGCCCACTGGTCCCTGGATGTTGCTGCCGACTCA
CAGGAGGAGCTGCAGGACTGGGTGAAAAAGATCCGTGAAGTGGCCCAGACAGCAGACGCCAGGGATTGTGACCAGATCCACGTTGATGAC
GTCTCATCAGATGACAATGGCCAAGATTTAAGCACATACAACTTCTCCGCTGACGGCTTCCACAGTTCGGCCCCAGGAGCCAACCTGTGC
CTGGGCTCTGGCGTGCACGGCGGCGTGGACTGGATGAGGAAGCTGGCCTTCCGCTACCGGCGGGTGAAGGAGATGTACAATACCTACAAG
AACAACGTTGGTGGGAAGGAGAGCTGCTTCGAGAGGATAATGCAGAGATTCGGCAGAAAAGCTGTCTACGTGGTGATCGGTGATGGTGTG
GAAGAGGAGCAAGGAGCGAAAAAGCACAACATGCCTTTCTGGCGGATATCCTGCCACGCAGACCTGGAGGCACTGAGGCACGCCCTGGAG
CTGGAGTATTTATAGCAGGATCAGCAGCATCTCCACCTGCCATCTCACCCTCAGACCCCCTCGCCTTCCCCACCTCCCCACCGAGAACTC
CAGAGACCCAGATGTTGGACACCAGGAAGGGGCCCCACAGCCGAGACGACGTGTCCAGTGACCATCTCAGAAGCCGTCCATCAGTCCAAA
TGGGGGTTCTGAGAAGGAAAGTACCCAACATTGGCTTCGGAGTATTTGACTTTGGGGAAAAGGGCTGGCTCGGAGTCTAGACTCTTCTGT
AAGACTCACAGAACAAAAGCAAGGAATTGCTGATTTGGGGGGTGCCTGGTGATGAGGAGGGGATGGGTTTGTCTTGTCTTCTTTTTAATT
TATGGACTAGTCTCATTACTCCGGAATTATGCTCTTGTACCTGTGTGGCTGGGTTTCTTAGTCGTTGGTTTGGTTTGGTTTTTTGAACTG
GTATGTGGGGTGGTTCACAGTTCTAATGTAAGCACTCTATTCTCCAAGTTGTGCTTTGTGGGGACAATCATTCTTTGAACATTAGAGAGG
AAGGCAGTTCAAGCTGTTGAAAAGACTATTGCTTATTTTTGTTTTTAAAGACCTACTTGACGTCATGTGGACAGTGCACGTGCCTTACGC
TACATCTTGTTTTCTAGGAAGAGGGGGATGCTGGGAAGGAATGGGTGCTTTGTGATGGATAAAAGGCATTAAATAAAACCACGTTTACAT

>66023_66023_8_PLCG1-EYA2_PLCG1_chr20_39798909_ENST00000373271_EYA2_chr20_45797787_ENST00000357410_length(amino acids)=1186AA_BP=1053
MRAGWVDRERRALPPPSRLRPRLRPVWGSRGAGAAGRRAGVLPTGARAPLFPAPKRGGASGQPRPAALRPRPVSACRSRRRVPLVCRLSL
SPNLSRRRCACSRAVLACAAAAPSVGAMAGAASPCANGCGPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQITWS
RGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWIKGLTWLMEDTLQAPTPLQI
ERWLRKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRAGER
PELCRVSLPEFQQFLLDYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVTFLFSKENSVWNSQLDAVCPDTMNNPLSHYWISS
SHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQR
NMAQYFKKVLGDTLLTKPVEISADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSMMYSENDISNSIKNGILYLEDPVNHEWYPHYFVLT
SSKIYYSEETSSDQGNEDEEEPKEVSSSTELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFWRNG
KVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQTNAHESKEWYHASLTRAQAEHMLMRVPRDGAFLV
RKRNEPNSYAISFRAEGKIKHCRVQQEGQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNPGFY
VEANPMPTFKCAVKALFDYKAQREDELTFIKSAIIQNVEKQEGGWWRGDYGGKKQLWFPSNYVEEMVNPVALEPEREHLDENSPLGDLLR
GVLDVPACQIAIRPEGKNNRLFVFSISMASVAHWSLDVAADSQEELQDWVKKIREVAQTADARDCDQIHVDDVSSDDNGQDLSTYNFSAD
GFHSSAPGANLCLGSGVHGGVDWMRKLAFRYRRVKEMYNTYKNNVGGKESCFERIMQRFGRKAVYVVIGDGVEEEQGAKKHNMPFWRISC

--------------------------------------------------------------
>66023_66023_9_PLCG1-EYA2_PLCG1_chr20_39798909_ENST00000373272_EYA2_chr20_45797786_ENST00000327619_length(transcript)=4563nt_BP=3213nt
GCCGCTCGTGGCCGCCGGGCTGTGTCCGGGGCCGCGTGAGAAAGCTCTGCGGGACTGAGGGCTGGGTGGGTCGACCGGGAACGGCGCGCG
CTCCCGCCGCCATCGCGCCTCCGTCCCCGCCTGCGGCCTGTCTGGGGGTCGCGGGGCGCAGGCGCGGCGGGCCGACGGGCGGGGGTCCTC
CCCACGGGTGCGCGGGCGCCTTTGTTCCCGGCGCCGAAGCGGGGTGGGGCCTCAGGGCAGCCCCGCCCCGCCGCGCTGAGGCCCCGCCCC
GTGTCCGCCTGCAGGAGCCGCCGCCGGGTCCCGCTCGTCTGCCGCCTCAGCCTCAGCCCCAACCTCAGCCGCCGCCGTTGCGCTTGCTCC
CGGGCGGTCCTGGCCTGTGCCGCCGCCGCCCCCAGCGTCGGAGCCATGGCGGGCGCCGCGTCCCCTTGCGCCAACGGCTGCGGGCCCGGC
GCGCCCTCGGACGCCGAGGTGCTGCACCTCTGCCGCAGCCTCGAGGTGGGCACCGTCATGACTTTGTTCTACTCCAAGAAGTCGCAGCGA
CCCGAGCGGAAGACCTTCCAGGTCAAGCTGGAGACGCGCCAGATCACGTGGAGCCGGGGCGCCGACAAGATCGAGGGGGCCATTGACATT
CGTGAAATTAAGGAGATCCGCCCAGGGAAGACCTCACGGGACTTTGATCGCTATCAAGAGGACCCAGCTTTCCGGCCGGACCAGTCACAT
TGCTTTGTCATTCTCTATGGAATGGAATTTCGCCTGAAAACGCTGAGCCTGCAAGCCACATCTGAGGATGAAGTGAACATGTGGATCAAG
GGCTTAACTTGGCTGATGGAGGATACATTGCAGGCACCCACACCCCTGCAGATTGAGAGGTGGCTCCGGAAGCAGTTTTACTCAGTGGAT
CGGAATCGTGAGGATCGTATATCAGCCAAGGACCTGAAGAACATGCTGTCCCAGGTCAACTACCGGGTCCCCAACATGCGCTTCCTCCGA
GAGCGGCTGACGGACCTGGAGCAGCGCAGCGGGGACATCACCTACGGGCAGTTTGCTCAGCTGTACCGCAGCCTCATGTACAGCGCCCAG
AAGACGATGGACCTCCCCTTCTTGGAAGCCAGTACTCTGAGGGCTGGGGAGCGGCCGGAGCTTTGCCGAGTGTCCCTTCCTGAGTTCCAG
CAGTTCCTTCTTGACTACCAGGGGGAGCTGTGGGCTGTTGATCGCCTCCAGGTGCAGGAGTTCATGCTCAGCTTCCTCCGAGACCCCTTA
CGAGAGATCGAGGAGCCATACTTCTTCCTGGATGAGTTTGTCACCTTCCTGTTCTCCAAAGAGAACAGTGTGTGGAACTCGCAGCTGGAT
GCAGTATGCCCGGACACCATGAACAACCCTCTTTCCCACTACTGGATCTCCTCCTCGCACAACACGTACCTGACCGGGGACCAGTTCTCC
AGTGAGTCCTCCTTGGAAGCCTATGCTCGCTGCCTGCGGATGGGCTGTCGCTGCATTGAGTTGGACTGCTGGGACGGCCCGGATGGGATG
CCAGTTATTTACCATGGGCACACCCTTACCACCAAGATCAAGTTCTCAGATGTCCTGCACACCATCAAGGAGCATGCCTTTGTGGCCTCA
GAGTACCCAGTCATCCTGTCCATTGAGGACCACTGCAGCATTGCCCAGCAGAGAAACATGGCCCAATACTTCAAGAAGGTGCTGGGGGAC
ACACTCCTCACCAAGCCCGTGGAGATCTCTGCCGACGGGCTCCCCTCACCCAACCAGCTTAAGAGGAAGATCCTCATCAAGCACAAGAAG
CTGGCTGAGGGCAGTGCCTACGAGGAGGTGCCTACATCCATGATGTACTCTGAGAACGACATCAGCAACTCTATCAAGAATGGCATCCTC
TACCTGGAGGACCCTGTGAACCACGAATGGTATCCCCACTACTTTGTTCTGACCAGCAGCAAGATCTACTACTCTGAGGAGACCAGCAGT
GACCAGGGCAACGAGGATGAGGAGGAGCCCAAGGAGGTCAGCAGCAGCACAGAGCTGCACTCCAATGAGAAGTGGTTCCATGGGAAGCTA
GGGGCAGGGCGTGACGGGCGTCACATCGCTGAGCGCCTGCTTACTGAGTACTGCATCGAGACCGGAGCCCCTGACGGCTCCTTCCTCGTG
CGAGAGAGTGAGACCTTCGTGGGCGACTACACGCTCTCTTTCTGGCGGAACGGGAAAGTCCAGCACTGCCGTATCCACTCCCGGCAAGAT
GCTGGGACCCCCAAGTTCTTCTTGACAGACAACCTCGTCTTTGACTCCCTCTATGACCTCATCACGCACTACCAGCAGGTGCCCCTGCGC
TGTAATGAGTTTGAGATGCGACTTTCAGAGCCTGTCCCACAGACCAACGCCCACGAGAGCAAAGAGTGGTACCACGCGAGCCTGACCAGA
GCACAGGCTGAGCACATGCTAATGCGCGTCCCTCGTGATGGGGCCTTCCTGGTGCGGAAGCGGAATGAACCCAACTCATATGCCATCTCT
TTCCGGGCTGAGGGCAAGATCAAGCATTGCCGTGTCCAGCAAGAGGGCCAGACAGTGATGCTAGGGAACTCGGAGTTCGACAGCCTTGTT
GACCTCATCAGCTACTATGAGAAACACCCGCTATACCGCAAGATGAAGCTGCGCTATCCCATCAACGAGGAGGCACTGGAGAAGATTGGC
ACAGCTGAGCCTGACTACGGGGCCCTGTATGAGGGACGCAACCCTGGCTTCTATGTAGAGGCAAACCCTATGCCAACTTTCAAGTGTGCA
GTCAAAGCCCTCTTTGACTACAAGGCCCAGAGGGAGGACGAGCTGACCTTCATCAAGAGCGCCATCATCCAGAATGTGGAGAAGCAAGAG
GGAGGCTGGTGGCGAGGGGACTACGGAGGGAAGAAGCAGCTGTGGTTCCCATCAAACTACGTGGAAGAGATGGTCAACCCCGTGGCCCTG
GAGCCGGAGAGGGAGCACTTGGACGAGAACAGCCCCCTAGGGGACTTGCTGCGGGGGGTCTTGGATGTGCCGGCTTGTCAGATTGCCATC
CGTCCTGAGGGCAAGAACAACCGGCTCTTCGTCTTCTCCATCAGCATGGCGTCGGTGGCCCACTGGTCCCTGGATGTTGCTGCCGACTCA
CAGGAGGAGCTGCAGGACTGGGTGAAAAAGATCCGTGAAGTGGCCCAGACAGCAGACGCCAGGGATTGTGACCAGATCCACGTTGATGAC
GTCTCATCAGATGACAATGGCCAAGATTTAAGCACATACAACTTCTCCGCTGACGGCTTCCACAGTTCGGCCCCAGGAGCCAACCTGTGC
CTGGGCTCTGGCGTGCACGGCGGCGTGGACTGGATGAGGAAGCTGGCCTTCCGCTACCGGCGGGTGAAGGAGATGTACAATACCTACAAG
AACAACGTTGGTGGGTTGATAGGCACTCCCAAAAGGGAGACCTGGCTACAGCTCCGAGCTGAGCTGGAAGCTCTCACAGACCTCTGGCTG
ACCCACTCCCTGAAGGCACTAAACCTCATCAACTCCCGGCCCAACTGTGTCAATGTGCTGGTCACCACCACTCAACTAATTCCTGCCCTG
GCCAAAGTCCTGCTATATGGCCTGGGGTCTGTGTTTCCTATTGAGAACATCTACAGTGCAACCAAGACAGGGAAGGAGAGCTGCTTCGAG
AGGATAATGCAGAGATTCGGCAGAAAAGCTGTCTACGTGGTGATCGGTGATGGTGTGGAAGAGGAGCAAGGAGCGAAAAAGCACAACATG
CCTTTCTGGCGGATATCCTGCCACGCAGACCTGGAGGCACTGAGGCACGCCCTGGAGCTGGAGTATTTATAGCAGGATCAGCAGCATCTC
CACCTGCCATCTCACCCTCAGACCCCCTCGCCTTCCCCACCTCCCCACCGAGAACTCCAGAGACCCAGATGTTGGACACCAGGAAGGGGC
CCCACAGCCGAGACGACGTGTCCAGTGACCATCTCAGAAGCCGTCCATCAGTCCAAATGGGGGTTCTGAGAAGGAAAGTACCCAACATTG
GCTTCGGAGTATTTGACTTTGGGGAAAAGGGCTGGCTCGGAGTCTAGACTCTTCTGTAAGACTCACAGAACAAAAGCAAGGAATTGCTGA
TTTGGGGGGTGCCTGGTGATGAGGAGGGGATGGGTTTGTCTTGTCTTCTTTTTAATTTATGGACTAGTCTCATTACTCCGGAATTATGCT
CTTGTACCTGTGTGGCTGGGTTTCTTAGTCGTTGGTTTGGTTTGGTTTTTTGAACTGGTATGTGGGGTGGTTCACAGTTCTAATGTAAGC
ACTCTATTCTCCAAGTTGTGCTTTGTGGGGACAATCATTCTTTGAACATTAGAGAGGAAGGCAGTTCAAGCTGTTGAAAAGACTATTGCT
TATTTTTGTTTTTAAAGACCTACTTGACGTCATGTGGACAGTGCACGTGCCTTACGCTACATCTTGTTTTCTAGGAAGAGGGGGATGCTG

>66023_66023_9_PLCG1-EYA2_PLCG1_chr20_39798909_ENST00000373272_EYA2_chr20_45797786_ENST00000327619_length(amino acids)=1265AA_BP=1053
MRAGWVDRERRALPPPSRLRPRLRPVWGSRGAGAAGRRAGVLPTGARAPLFPAPKRGGASGQPRPAALRPRPVSACRSRRRVPLVCRLSL
SPNLSRRRCACSRAVLACAAAAPSVGAMAGAASPCANGCGPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQITWS
RGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWIKGLTWLMEDTLQAPTPLQI
ERWLRKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRAGER
PELCRVSLPEFQQFLLDYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVTFLFSKENSVWNSQLDAVCPDTMNNPLSHYWISS
SHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQR
NMAQYFKKVLGDTLLTKPVEISADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSMMYSENDISNSIKNGILYLEDPVNHEWYPHYFVLT
SSKIYYSEETSSDQGNEDEEEPKEVSSSTELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFWRNG
KVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQTNAHESKEWYHASLTRAQAEHMLMRVPRDGAFLV
RKRNEPNSYAISFRAEGKIKHCRVQQEGQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNPGFY
VEANPMPTFKCAVKALFDYKAQREDELTFIKSAIIQNVEKQEGGWWRGDYGGKKQLWFPSNYVEEMVNPVALEPEREHLDENSPLGDLLR
GVLDVPACQIAIRPEGKNNRLFVFSISMASVAHWSLDVAADSQEELQDWVKKIREVAQTADARDCDQIHVDDVSSDDNGQDLSTYNFSAD
GFHSSAPGANLCLGSGVHGGVDWMRKLAFRYRRVKEMYNTYKNNVGGLIGTPKRETWLQLRAELEALTDLWLTHSLKALNLINSRPNCVN
VLVTTTQLIPALAKVLLYGLGSVFPIENIYSATKTGKESCFERIMQRFGRKAVYVVIGDGVEEEQGAKKHNMPFWRISCHADLEALRHAL

--------------------------------------------------------------
>66023_66023_10_PLCG1-EYA2_PLCG1_chr20_39798909_ENST00000373272_EYA2_chr20_45797786_ENST00000357410_length(transcript)=4326nt_BP=3213nt
GCCGCTCGTGGCCGCCGGGCTGTGTCCGGGGCCGCGTGAGAAAGCTCTGCGGGACTGAGGGCTGGGTGGGTCGACCGGGAACGGCGCGCG
CTCCCGCCGCCATCGCGCCTCCGTCCCCGCCTGCGGCCTGTCTGGGGGTCGCGGGGCGCAGGCGCGGCGGGCCGACGGGCGGGGGTCCTC
CCCACGGGTGCGCGGGCGCCTTTGTTCCCGGCGCCGAAGCGGGGTGGGGCCTCAGGGCAGCCCCGCCCCGCCGCGCTGAGGCCCCGCCCC
GTGTCCGCCTGCAGGAGCCGCCGCCGGGTCCCGCTCGTCTGCCGCCTCAGCCTCAGCCCCAACCTCAGCCGCCGCCGTTGCGCTTGCTCC
CGGGCGGTCCTGGCCTGTGCCGCCGCCGCCCCCAGCGTCGGAGCCATGGCGGGCGCCGCGTCCCCTTGCGCCAACGGCTGCGGGCCCGGC
GCGCCCTCGGACGCCGAGGTGCTGCACCTCTGCCGCAGCCTCGAGGTGGGCACCGTCATGACTTTGTTCTACTCCAAGAAGTCGCAGCGA
CCCGAGCGGAAGACCTTCCAGGTCAAGCTGGAGACGCGCCAGATCACGTGGAGCCGGGGCGCCGACAAGATCGAGGGGGCCATTGACATT
CGTGAAATTAAGGAGATCCGCCCAGGGAAGACCTCACGGGACTTTGATCGCTATCAAGAGGACCCAGCTTTCCGGCCGGACCAGTCACAT
TGCTTTGTCATTCTCTATGGAATGGAATTTCGCCTGAAAACGCTGAGCCTGCAAGCCACATCTGAGGATGAAGTGAACATGTGGATCAAG
GGCTTAACTTGGCTGATGGAGGATACATTGCAGGCACCCACACCCCTGCAGATTGAGAGGTGGCTCCGGAAGCAGTTTTACTCAGTGGAT
CGGAATCGTGAGGATCGTATATCAGCCAAGGACCTGAAGAACATGCTGTCCCAGGTCAACTACCGGGTCCCCAACATGCGCTTCCTCCGA
GAGCGGCTGACGGACCTGGAGCAGCGCAGCGGGGACATCACCTACGGGCAGTTTGCTCAGCTGTACCGCAGCCTCATGTACAGCGCCCAG
AAGACGATGGACCTCCCCTTCTTGGAAGCCAGTACTCTGAGGGCTGGGGAGCGGCCGGAGCTTTGCCGAGTGTCCCTTCCTGAGTTCCAG
CAGTTCCTTCTTGACTACCAGGGGGAGCTGTGGGCTGTTGATCGCCTCCAGGTGCAGGAGTTCATGCTCAGCTTCCTCCGAGACCCCTTA
CGAGAGATCGAGGAGCCATACTTCTTCCTGGATGAGTTTGTCACCTTCCTGTTCTCCAAAGAGAACAGTGTGTGGAACTCGCAGCTGGAT
GCAGTATGCCCGGACACCATGAACAACCCTCTTTCCCACTACTGGATCTCCTCCTCGCACAACACGTACCTGACCGGGGACCAGTTCTCC
AGTGAGTCCTCCTTGGAAGCCTATGCTCGCTGCCTGCGGATGGGCTGTCGCTGCATTGAGTTGGACTGCTGGGACGGCCCGGATGGGATG
CCAGTTATTTACCATGGGCACACCCTTACCACCAAGATCAAGTTCTCAGATGTCCTGCACACCATCAAGGAGCATGCCTTTGTGGCCTCA
GAGTACCCAGTCATCCTGTCCATTGAGGACCACTGCAGCATTGCCCAGCAGAGAAACATGGCCCAATACTTCAAGAAGGTGCTGGGGGAC
ACACTCCTCACCAAGCCCGTGGAGATCTCTGCCGACGGGCTCCCCTCACCCAACCAGCTTAAGAGGAAGATCCTCATCAAGCACAAGAAG
CTGGCTGAGGGCAGTGCCTACGAGGAGGTGCCTACATCCATGATGTACTCTGAGAACGACATCAGCAACTCTATCAAGAATGGCATCCTC
TACCTGGAGGACCCTGTGAACCACGAATGGTATCCCCACTACTTTGTTCTGACCAGCAGCAAGATCTACTACTCTGAGGAGACCAGCAGT
GACCAGGGCAACGAGGATGAGGAGGAGCCCAAGGAGGTCAGCAGCAGCACAGAGCTGCACTCCAATGAGAAGTGGTTCCATGGGAAGCTA
GGGGCAGGGCGTGACGGGCGTCACATCGCTGAGCGCCTGCTTACTGAGTACTGCATCGAGACCGGAGCCCCTGACGGCTCCTTCCTCGTG
CGAGAGAGTGAGACCTTCGTGGGCGACTACACGCTCTCTTTCTGGCGGAACGGGAAAGTCCAGCACTGCCGTATCCACTCCCGGCAAGAT
GCTGGGACCCCCAAGTTCTTCTTGACAGACAACCTCGTCTTTGACTCCCTCTATGACCTCATCACGCACTACCAGCAGGTGCCCCTGCGC
TGTAATGAGTTTGAGATGCGACTTTCAGAGCCTGTCCCACAGACCAACGCCCACGAGAGCAAAGAGTGGTACCACGCGAGCCTGACCAGA
GCACAGGCTGAGCACATGCTAATGCGCGTCCCTCGTGATGGGGCCTTCCTGGTGCGGAAGCGGAATGAACCCAACTCATATGCCATCTCT
TTCCGGGCTGAGGGCAAGATCAAGCATTGCCGTGTCCAGCAAGAGGGCCAGACAGTGATGCTAGGGAACTCGGAGTTCGACAGCCTTGTT
GACCTCATCAGCTACTATGAGAAACACCCGCTATACCGCAAGATGAAGCTGCGCTATCCCATCAACGAGGAGGCACTGGAGAAGATTGGC
ACAGCTGAGCCTGACTACGGGGCCCTGTATGAGGGACGCAACCCTGGCTTCTATGTAGAGGCAAACCCTATGCCAACTTTCAAGTGTGCA
GTCAAAGCCCTCTTTGACTACAAGGCCCAGAGGGAGGACGAGCTGACCTTCATCAAGAGCGCCATCATCCAGAATGTGGAGAAGCAAGAG
GGAGGCTGGTGGCGAGGGGACTACGGAGGGAAGAAGCAGCTGTGGTTCCCATCAAACTACGTGGAAGAGATGGTCAACCCCGTGGCCCTG
GAGCCGGAGAGGGAGCACTTGGACGAGAACAGCCCCCTAGGGGACTTGCTGCGGGGGGTCTTGGATGTGCCGGCTTGTCAGATTGCCATC
CGTCCTGAGGGCAAGAACAACCGGCTCTTCGTCTTCTCCATCAGCATGGCGTCGGTGGCCCACTGGTCCCTGGATGTTGCTGCCGACTCA
CAGGAGGAGCTGCAGGACTGGGTGAAAAAGATCCGTGAAGTGGCCCAGACAGCAGACGCCAGGGATTGTGACCAGATCCACGTTGATGAC
GTCTCATCAGATGACAATGGCCAAGATTTAAGCACATACAACTTCTCCGCTGACGGCTTCCACAGTTCGGCCCCAGGAGCCAACCTGTGC
CTGGGCTCTGGCGTGCACGGCGGCGTGGACTGGATGAGGAAGCTGGCCTTCCGCTACCGGCGGGTGAAGGAGATGTACAATACCTACAAG
AACAACGTTGGTGGGAAGGAGAGCTGCTTCGAGAGGATAATGCAGAGATTCGGCAGAAAAGCTGTCTACGTGGTGATCGGTGATGGTGTG
GAAGAGGAGCAAGGAGCGAAAAAGCACAACATGCCTTTCTGGCGGATATCCTGCCACGCAGACCTGGAGGCACTGAGGCACGCCCTGGAG
CTGGAGTATTTATAGCAGGATCAGCAGCATCTCCACCTGCCATCTCACCCTCAGACCCCCTCGCCTTCCCCACCTCCCCACCGAGAACTC
CAGAGACCCAGATGTTGGACACCAGGAAGGGGCCCCACAGCCGAGACGACGTGTCCAGTGACCATCTCAGAAGCCGTCCATCAGTCCAAA
TGGGGGTTCTGAGAAGGAAAGTACCCAACATTGGCTTCGGAGTATTTGACTTTGGGGAAAAGGGCTGGCTCGGAGTCTAGACTCTTCTGT
AAGACTCACAGAACAAAAGCAAGGAATTGCTGATTTGGGGGGTGCCTGGTGATGAGGAGGGGATGGGTTTGTCTTGTCTTCTTTTTAATT
TATGGACTAGTCTCATTACTCCGGAATTATGCTCTTGTACCTGTGTGGCTGGGTTTCTTAGTCGTTGGTTTGGTTTGGTTTTTTGAACTG
GTATGTGGGGTGGTTCACAGTTCTAATGTAAGCACTCTATTCTCCAAGTTGTGCTTTGTGGGGACAATCATTCTTTGAACATTAGAGAGG
AAGGCAGTTCAAGCTGTTGAAAAGACTATTGCTTATTTTTGTTTTTAAAGACCTACTTGACGTCATGTGGACAGTGCACGTGCCTTACGC
TACATCTTGTTTTCTAGGAAGAGGGGGATGCTGGGAAGGAATGGGTGCTTTGTGATGGATAAAAGGCATTAAATAAAACCACGTTTACAT

>66023_66023_10_PLCG1-EYA2_PLCG1_chr20_39798909_ENST00000373272_EYA2_chr20_45797786_ENST00000357410_length(amino acids)=1186AA_BP=1053
MRAGWVDRERRALPPPSRLRPRLRPVWGSRGAGAAGRRAGVLPTGARAPLFPAPKRGGASGQPRPAALRPRPVSACRSRRRVPLVCRLSL
SPNLSRRRCACSRAVLACAAAAPSVGAMAGAASPCANGCGPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQITWS
RGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWIKGLTWLMEDTLQAPTPLQI
ERWLRKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRAGER
PELCRVSLPEFQQFLLDYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVTFLFSKENSVWNSQLDAVCPDTMNNPLSHYWISS
SHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQR
NMAQYFKKVLGDTLLTKPVEISADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSMMYSENDISNSIKNGILYLEDPVNHEWYPHYFVLT
SSKIYYSEETSSDQGNEDEEEPKEVSSSTELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFWRNG
KVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQTNAHESKEWYHASLTRAQAEHMLMRVPRDGAFLV
RKRNEPNSYAISFRAEGKIKHCRVQQEGQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNPGFY
VEANPMPTFKCAVKALFDYKAQREDELTFIKSAIIQNVEKQEGGWWRGDYGGKKQLWFPSNYVEEMVNPVALEPEREHLDENSPLGDLLR
GVLDVPACQIAIRPEGKNNRLFVFSISMASVAHWSLDVAADSQEELQDWVKKIREVAQTADARDCDQIHVDDVSSDDNGQDLSTYNFSAD
GFHSSAPGANLCLGSGVHGGVDWMRKLAFRYRRVKEMYNTYKNNVGGKESCFERIMQRFGRKAVYVVIGDGVEEEQGAKKHNMPFWRISC

--------------------------------------------------------------
>66023_66023_11_PLCG1-EYA2_PLCG1_chr20_39798909_ENST00000373272_EYA2_chr20_45797787_ENST00000327619_length(transcript)=4563nt_BP=3213nt
GCCGCTCGTGGCCGCCGGGCTGTGTCCGGGGCCGCGTGAGAAAGCTCTGCGGGACTGAGGGCTGGGTGGGTCGACCGGGAACGGCGCGCG
CTCCCGCCGCCATCGCGCCTCCGTCCCCGCCTGCGGCCTGTCTGGGGGTCGCGGGGCGCAGGCGCGGCGGGCCGACGGGCGGGGGTCCTC
CCCACGGGTGCGCGGGCGCCTTTGTTCCCGGCGCCGAAGCGGGGTGGGGCCTCAGGGCAGCCCCGCCCCGCCGCGCTGAGGCCCCGCCCC
GTGTCCGCCTGCAGGAGCCGCCGCCGGGTCCCGCTCGTCTGCCGCCTCAGCCTCAGCCCCAACCTCAGCCGCCGCCGTTGCGCTTGCTCC
CGGGCGGTCCTGGCCTGTGCCGCCGCCGCCCCCAGCGTCGGAGCCATGGCGGGCGCCGCGTCCCCTTGCGCCAACGGCTGCGGGCCCGGC
GCGCCCTCGGACGCCGAGGTGCTGCACCTCTGCCGCAGCCTCGAGGTGGGCACCGTCATGACTTTGTTCTACTCCAAGAAGTCGCAGCGA
CCCGAGCGGAAGACCTTCCAGGTCAAGCTGGAGACGCGCCAGATCACGTGGAGCCGGGGCGCCGACAAGATCGAGGGGGCCATTGACATT
CGTGAAATTAAGGAGATCCGCCCAGGGAAGACCTCACGGGACTTTGATCGCTATCAAGAGGACCCAGCTTTCCGGCCGGACCAGTCACAT
TGCTTTGTCATTCTCTATGGAATGGAATTTCGCCTGAAAACGCTGAGCCTGCAAGCCACATCTGAGGATGAAGTGAACATGTGGATCAAG
GGCTTAACTTGGCTGATGGAGGATACATTGCAGGCACCCACACCCCTGCAGATTGAGAGGTGGCTCCGGAAGCAGTTTTACTCAGTGGAT
CGGAATCGTGAGGATCGTATATCAGCCAAGGACCTGAAGAACATGCTGTCCCAGGTCAACTACCGGGTCCCCAACATGCGCTTCCTCCGA
GAGCGGCTGACGGACCTGGAGCAGCGCAGCGGGGACATCACCTACGGGCAGTTTGCTCAGCTGTACCGCAGCCTCATGTACAGCGCCCAG
AAGACGATGGACCTCCCCTTCTTGGAAGCCAGTACTCTGAGGGCTGGGGAGCGGCCGGAGCTTTGCCGAGTGTCCCTTCCTGAGTTCCAG
CAGTTCCTTCTTGACTACCAGGGGGAGCTGTGGGCTGTTGATCGCCTCCAGGTGCAGGAGTTCATGCTCAGCTTCCTCCGAGACCCCTTA
CGAGAGATCGAGGAGCCATACTTCTTCCTGGATGAGTTTGTCACCTTCCTGTTCTCCAAAGAGAACAGTGTGTGGAACTCGCAGCTGGAT
GCAGTATGCCCGGACACCATGAACAACCCTCTTTCCCACTACTGGATCTCCTCCTCGCACAACACGTACCTGACCGGGGACCAGTTCTCC
AGTGAGTCCTCCTTGGAAGCCTATGCTCGCTGCCTGCGGATGGGCTGTCGCTGCATTGAGTTGGACTGCTGGGACGGCCCGGATGGGATG
CCAGTTATTTACCATGGGCACACCCTTACCACCAAGATCAAGTTCTCAGATGTCCTGCACACCATCAAGGAGCATGCCTTTGTGGCCTCA
GAGTACCCAGTCATCCTGTCCATTGAGGACCACTGCAGCATTGCCCAGCAGAGAAACATGGCCCAATACTTCAAGAAGGTGCTGGGGGAC
ACACTCCTCACCAAGCCCGTGGAGATCTCTGCCGACGGGCTCCCCTCACCCAACCAGCTTAAGAGGAAGATCCTCATCAAGCACAAGAAG
CTGGCTGAGGGCAGTGCCTACGAGGAGGTGCCTACATCCATGATGTACTCTGAGAACGACATCAGCAACTCTATCAAGAATGGCATCCTC
TACCTGGAGGACCCTGTGAACCACGAATGGTATCCCCACTACTTTGTTCTGACCAGCAGCAAGATCTACTACTCTGAGGAGACCAGCAGT
GACCAGGGCAACGAGGATGAGGAGGAGCCCAAGGAGGTCAGCAGCAGCACAGAGCTGCACTCCAATGAGAAGTGGTTCCATGGGAAGCTA
GGGGCAGGGCGTGACGGGCGTCACATCGCTGAGCGCCTGCTTACTGAGTACTGCATCGAGACCGGAGCCCCTGACGGCTCCTTCCTCGTG
CGAGAGAGTGAGACCTTCGTGGGCGACTACACGCTCTCTTTCTGGCGGAACGGGAAAGTCCAGCACTGCCGTATCCACTCCCGGCAAGAT
GCTGGGACCCCCAAGTTCTTCTTGACAGACAACCTCGTCTTTGACTCCCTCTATGACCTCATCACGCACTACCAGCAGGTGCCCCTGCGC
TGTAATGAGTTTGAGATGCGACTTTCAGAGCCTGTCCCACAGACCAACGCCCACGAGAGCAAAGAGTGGTACCACGCGAGCCTGACCAGA
GCACAGGCTGAGCACATGCTAATGCGCGTCCCTCGTGATGGGGCCTTCCTGGTGCGGAAGCGGAATGAACCCAACTCATATGCCATCTCT
TTCCGGGCTGAGGGCAAGATCAAGCATTGCCGTGTCCAGCAAGAGGGCCAGACAGTGATGCTAGGGAACTCGGAGTTCGACAGCCTTGTT
GACCTCATCAGCTACTATGAGAAACACCCGCTATACCGCAAGATGAAGCTGCGCTATCCCATCAACGAGGAGGCACTGGAGAAGATTGGC
ACAGCTGAGCCTGACTACGGGGCCCTGTATGAGGGACGCAACCCTGGCTTCTATGTAGAGGCAAACCCTATGCCAACTTTCAAGTGTGCA
GTCAAAGCCCTCTTTGACTACAAGGCCCAGAGGGAGGACGAGCTGACCTTCATCAAGAGCGCCATCATCCAGAATGTGGAGAAGCAAGAG
GGAGGCTGGTGGCGAGGGGACTACGGAGGGAAGAAGCAGCTGTGGTTCCCATCAAACTACGTGGAAGAGATGGTCAACCCCGTGGCCCTG
GAGCCGGAGAGGGAGCACTTGGACGAGAACAGCCCCCTAGGGGACTTGCTGCGGGGGGTCTTGGATGTGCCGGCTTGTCAGATTGCCATC
CGTCCTGAGGGCAAGAACAACCGGCTCTTCGTCTTCTCCATCAGCATGGCGTCGGTGGCCCACTGGTCCCTGGATGTTGCTGCCGACTCA
CAGGAGGAGCTGCAGGACTGGGTGAAAAAGATCCGTGAAGTGGCCCAGACAGCAGACGCCAGGGATTGTGACCAGATCCACGTTGATGAC
GTCTCATCAGATGACAATGGCCAAGATTTAAGCACATACAACTTCTCCGCTGACGGCTTCCACAGTTCGGCCCCAGGAGCCAACCTGTGC
CTGGGCTCTGGCGTGCACGGCGGCGTGGACTGGATGAGGAAGCTGGCCTTCCGCTACCGGCGGGTGAAGGAGATGTACAATACCTACAAG
AACAACGTTGGTGGGTTGATAGGCACTCCCAAAAGGGAGACCTGGCTACAGCTCCGAGCTGAGCTGGAAGCTCTCACAGACCTCTGGCTG
ACCCACTCCCTGAAGGCACTAAACCTCATCAACTCCCGGCCCAACTGTGTCAATGTGCTGGTCACCACCACTCAACTAATTCCTGCCCTG
GCCAAAGTCCTGCTATATGGCCTGGGGTCTGTGTTTCCTATTGAGAACATCTACAGTGCAACCAAGACAGGGAAGGAGAGCTGCTTCGAG
AGGATAATGCAGAGATTCGGCAGAAAAGCTGTCTACGTGGTGATCGGTGATGGTGTGGAAGAGGAGCAAGGAGCGAAAAAGCACAACATG
CCTTTCTGGCGGATATCCTGCCACGCAGACCTGGAGGCACTGAGGCACGCCCTGGAGCTGGAGTATTTATAGCAGGATCAGCAGCATCTC
CACCTGCCATCTCACCCTCAGACCCCCTCGCCTTCCCCACCTCCCCACCGAGAACTCCAGAGACCCAGATGTTGGACACCAGGAAGGGGC
CCCACAGCCGAGACGACGTGTCCAGTGACCATCTCAGAAGCCGTCCATCAGTCCAAATGGGGGTTCTGAGAAGGAAAGTACCCAACATTG
GCTTCGGAGTATTTGACTTTGGGGAAAAGGGCTGGCTCGGAGTCTAGACTCTTCTGTAAGACTCACAGAACAAAAGCAAGGAATTGCTGA
TTTGGGGGGTGCCTGGTGATGAGGAGGGGATGGGTTTGTCTTGTCTTCTTTTTAATTTATGGACTAGTCTCATTACTCCGGAATTATGCT
CTTGTACCTGTGTGGCTGGGTTTCTTAGTCGTTGGTTTGGTTTGGTTTTTTGAACTGGTATGTGGGGTGGTTCACAGTTCTAATGTAAGC
ACTCTATTCTCCAAGTTGTGCTTTGTGGGGACAATCATTCTTTGAACATTAGAGAGGAAGGCAGTTCAAGCTGTTGAAAAGACTATTGCT
TATTTTTGTTTTTAAAGACCTACTTGACGTCATGTGGACAGTGCACGTGCCTTACGCTACATCTTGTTTTCTAGGAAGAGGGGGATGCTG

>66023_66023_11_PLCG1-EYA2_PLCG1_chr20_39798909_ENST00000373272_EYA2_chr20_45797787_ENST00000327619_length(amino acids)=1265AA_BP=1053
MRAGWVDRERRALPPPSRLRPRLRPVWGSRGAGAAGRRAGVLPTGARAPLFPAPKRGGASGQPRPAALRPRPVSACRSRRRVPLVCRLSL
SPNLSRRRCACSRAVLACAAAAPSVGAMAGAASPCANGCGPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQITWS
RGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWIKGLTWLMEDTLQAPTPLQI
ERWLRKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRAGER
PELCRVSLPEFQQFLLDYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVTFLFSKENSVWNSQLDAVCPDTMNNPLSHYWISS
SHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQR
NMAQYFKKVLGDTLLTKPVEISADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSMMYSENDISNSIKNGILYLEDPVNHEWYPHYFVLT
SSKIYYSEETSSDQGNEDEEEPKEVSSSTELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFWRNG
KVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQTNAHESKEWYHASLTRAQAEHMLMRVPRDGAFLV
RKRNEPNSYAISFRAEGKIKHCRVQQEGQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNPGFY
VEANPMPTFKCAVKALFDYKAQREDELTFIKSAIIQNVEKQEGGWWRGDYGGKKQLWFPSNYVEEMVNPVALEPEREHLDENSPLGDLLR
GVLDVPACQIAIRPEGKNNRLFVFSISMASVAHWSLDVAADSQEELQDWVKKIREVAQTADARDCDQIHVDDVSSDDNGQDLSTYNFSAD
GFHSSAPGANLCLGSGVHGGVDWMRKLAFRYRRVKEMYNTYKNNVGGLIGTPKRETWLQLRAELEALTDLWLTHSLKALNLINSRPNCVN
VLVTTTQLIPALAKVLLYGLGSVFPIENIYSATKTGKESCFERIMQRFGRKAVYVVIGDGVEEEQGAKKHNMPFWRISCHADLEALRHAL

--------------------------------------------------------------
>66023_66023_12_PLCG1-EYA2_PLCG1_chr20_39798909_ENST00000373272_EYA2_chr20_45797787_ENST00000357410_length(transcript)=4326nt_BP=3213nt
GCCGCTCGTGGCCGCCGGGCTGTGTCCGGGGCCGCGTGAGAAAGCTCTGCGGGACTGAGGGCTGGGTGGGTCGACCGGGAACGGCGCGCG
CTCCCGCCGCCATCGCGCCTCCGTCCCCGCCTGCGGCCTGTCTGGGGGTCGCGGGGCGCAGGCGCGGCGGGCCGACGGGCGGGGGTCCTC
CCCACGGGTGCGCGGGCGCCTTTGTTCCCGGCGCCGAAGCGGGGTGGGGCCTCAGGGCAGCCCCGCCCCGCCGCGCTGAGGCCCCGCCCC
GTGTCCGCCTGCAGGAGCCGCCGCCGGGTCCCGCTCGTCTGCCGCCTCAGCCTCAGCCCCAACCTCAGCCGCCGCCGTTGCGCTTGCTCC
CGGGCGGTCCTGGCCTGTGCCGCCGCCGCCCCCAGCGTCGGAGCCATGGCGGGCGCCGCGTCCCCTTGCGCCAACGGCTGCGGGCCCGGC
GCGCCCTCGGACGCCGAGGTGCTGCACCTCTGCCGCAGCCTCGAGGTGGGCACCGTCATGACTTTGTTCTACTCCAAGAAGTCGCAGCGA
CCCGAGCGGAAGACCTTCCAGGTCAAGCTGGAGACGCGCCAGATCACGTGGAGCCGGGGCGCCGACAAGATCGAGGGGGCCATTGACATT
CGTGAAATTAAGGAGATCCGCCCAGGGAAGACCTCACGGGACTTTGATCGCTATCAAGAGGACCCAGCTTTCCGGCCGGACCAGTCACAT
TGCTTTGTCATTCTCTATGGAATGGAATTTCGCCTGAAAACGCTGAGCCTGCAAGCCACATCTGAGGATGAAGTGAACATGTGGATCAAG
GGCTTAACTTGGCTGATGGAGGATACATTGCAGGCACCCACACCCCTGCAGATTGAGAGGTGGCTCCGGAAGCAGTTTTACTCAGTGGAT
CGGAATCGTGAGGATCGTATATCAGCCAAGGACCTGAAGAACATGCTGTCCCAGGTCAACTACCGGGTCCCCAACATGCGCTTCCTCCGA
GAGCGGCTGACGGACCTGGAGCAGCGCAGCGGGGACATCACCTACGGGCAGTTTGCTCAGCTGTACCGCAGCCTCATGTACAGCGCCCAG
AAGACGATGGACCTCCCCTTCTTGGAAGCCAGTACTCTGAGGGCTGGGGAGCGGCCGGAGCTTTGCCGAGTGTCCCTTCCTGAGTTCCAG
CAGTTCCTTCTTGACTACCAGGGGGAGCTGTGGGCTGTTGATCGCCTCCAGGTGCAGGAGTTCATGCTCAGCTTCCTCCGAGACCCCTTA
CGAGAGATCGAGGAGCCATACTTCTTCCTGGATGAGTTTGTCACCTTCCTGTTCTCCAAAGAGAACAGTGTGTGGAACTCGCAGCTGGAT
GCAGTATGCCCGGACACCATGAACAACCCTCTTTCCCACTACTGGATCTCCTCCTCGCACAACACGTACCTGACCGGGGACCAGTTCTCC
AGTGAGTCCTCCTTGGAAGCCTATGCTCGCTGCCTGCGGATGGGCTGTCGCTGCATTGAGTTGGACTGCTGGGACGGCCCGGATGGGATG
CCAGTTATTTACCATGGGCACACCCTTACCACCAAGATCAAGTTCTCAGATGTCCTGCACACCATCAAGGAGCATGCCTTTGTGGCCTCA
GAGTACCCAGTCATCCTGTCCATTGAGGACCACTGCAGCATTGCCCAGCAGAGAAACATGGCCCAATACTTCAAGAAGGTGCTGGGGGAC
ACACTCCTCACCAAGCCCGTGGAGATCTCTGCCGACGGGCTCCCCTCACCCAACCAGCTTAAGAGGAAGATCCTCATCAAGCACAAGAAG
CTGGCTGAGGGCAGTGCCTACGAGGAGGTGCCTACATCCATGATGTACTCTGAGAACGACATCAGCAACTCTATCAAGAATGGCATCCTC
TACCTGGAGGACCCTGTGAACCACGAATGGTATCCCCACTACTTTGTTCTGACCAGCAGCAAGATCTACTACTCTGAGGAGACCAGCAGT
GACCAGGGCAACGAGGATGAGGAGGAGCCCAAGGAGGTCAGCAGCAGCACAGAGCTGCACTCCAATGAGAAGTGGTTCCATGGGAAGCTA
GGGGCAGGGCGTGACGGGCGTCACATCGCTGAGCGCCTGCTTACTGAGTACTGCATCGAGACCGGAGCCCCTGACGGCTCCTTCCTCGTG
CGAGAGAGTGAGACCTTCGTGGGCGACTACACGCTCTCTTTCTGGCGGAACGGGAAAGTCCAGCACTGCCGTATCCACTCCCGGCAAGAT
GCTGGGACCCCCAAGTTCTTCTTGACAGACAACCTCGTCTTTGACTCCCTCTATGACCTCATCACGCACTACCAGCAGGTGCCCCTGCGC
TGTAATGAGTTTGAGATGCGACTTTCAGAGCCTGTCCCACAGACCAACGCCCACGAGAGCAAAGAGTGGTACCACGCGAGCCTGACCAGA
GCACAGGCTGAGCACATGCTAATGCGCGTCCCTCGTGATGGGGCCTTCCTGGTGCGGAAGCGGAATGAACCCAACTCATATGCCATCTCT
TTCCGGGCTGAGGGCAAGATCAAGCATTGCCGTGTCCAGCAAGAGGGCCAGACAGTGATGCTAGGGAACTCGGAGTTCGACAGCCTTGTT
GACCTCATCAGCTACTATGAGAAACACCCGCTATACCGCAAGATGAAGCTGCGCTATCCCATCAACGAGGAGGCACTGGAGAAGATTGGC
ACAGCTGAGCCTGACTACGGGGCCCTGTATGAGGGACGCAACCCTGGCTTCTATGTAGAGGCAAACCCTATGCCAACTTTCAAGTGTGCA
GTCAAAGCCCTCTTTGACTACAAGGCCCAGAGGGAGGACGAGCTGACCTTCATCAAGAGCGCCATCATCCAGAATGTGGAGAAGCAAGAG
GGAGGCTGGTGGCGAGGGGACTACGGAGGGAAGAAGCAGCTGTGGTTCCCATCAAACTACGTGGAAGAGATGGTCAACCCCGTGGCCCTG
GAGCCGGAGAGGGAGCACTTGGACGAGAACAGCCCCCTAGGGGACTTGCTGCGGGGGGTCTTGGATGTGCCGGCTTGTCAGATTGCCATC
CGTCCTGAGGGCAAGAACAACCGGCTCTTCGTCTTCTCCATCAGCATGGCGTCGGTGGCCCACTGGTCCCTGGATGTTGCTGCCGACTCA
CAGGAGGAGCTGCAGGACTGGGTGAAAAAGATCCGTGAAGTGGCCCAGACAGCAGACGCCAGGGATTGTGACCAGATCCACGTTGATGAC
GTCTCATCAGATGACAATGGCCAAGATTTAAGCACATACAACTTCTCCGCTGACGGCTTCCACAGTTCGGCCCCAGGAGCCAACCTGTGC
CTGGGCTCTGGCGTGCACGGCGGCGTGGACTGGATGAGGAAGCTGGCCTTCCGCTACCGGCGGGTGAAGGAGATGTACAATACCTACAAG
AACAACGTTGGTGGGAAGGAGAGCTGCTTCGAGAGGATAATGCAGAGATTCGGCAGAAAAGCTGTCTACGTGGTGATCGGTGATGGTGTG
GAAGAGGAGCAAGGAGCGAAAAAGCACAACATGCCTTTCTGGCGGATATCCTGCCACGCAGACCTGGAGGCACTGAGGCACGCCCTGGAG
CTGGAGTATTTATAGCAGGATCAGCAGCATCTCCACCTGCCATCTCACCCTCAGACCCCCTCGCCTTCCCCACCTCCCCACCGAGAACTC
CAGAGACCCAGATGTTGGACACCAGGAAGGGGCCCCACAGCCGAGACGACGTGTCCAGTGACCATCTCAGAAGCCGTCCATCAGTCCAAA
TGGGGGTTCTGAGAAGGAAAGTACCCAACATTGGCTTCGGAGTATTTGACTTTGGGGAAAAGGGCTGGCTCGGAGTCTAGACTCTTCTGT
AAGACTCACAGAACAAAAGCAAGGAATTGCTGATTTGGGGGGTGCCTGGTGATGAGGAGGGGATGGGTTTGTCTTGTCTTCTTTTTAATT
TATGGACTAGTCTCATTACTCCGGAATTATGCTCTTGTACCTGTGTGGCTGGGTTTCTTAGTCGTTGGTTTGGTTTGGTTTTTTGAACTG
GTATGTGGGGTGGTTCACAGTTCTAATGTAAGCACTCTATTCTCCAAGTTGTGCTTTGTGGGGACAATCATTCTTTGAACATTAGAGAGG
AAGGCAGTTCAAGCTGTTGAAAAGACTATTGCTTATTTTTGTTTTTAAAGACCTACTTGACGTCATGTGGACAGTGCACGTGCCTTACGC
TACATCTTGTTTTCTAGGAAGAGGGGGATGCTGGGAAGGAATGGGTGCTTTGTGATGGATAAAAGGCATTAAATAAAACCACGTTTACAT

>66023_66023_12_PLCG1-EYA2_PLCG1_chr20_39798909_ENST00000373272_EYA2_chr20_45797787_ENST00000357410_length(amino acids)=1186AA_BP=1053
MRAGWVDRERRALPPPSRLRPRLRPVWGSRGAGAAGRRAGVLPTGARAPLFPAPKRGGASGQPRPAALRPRPVSACRSRRRVPLVCRLSL
SPNLSRRRCACSRAVLACAAAAPSVGAMAGAASPCANGCGPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQITWS
RGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWIKGLTWLMEDTLQAPTPLQI
ERWLRKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRAGER
PELCRVSLPEFQQFLLDYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVTFLFSKENSVWNSQLDAVCPDTMNNPLSHYWISS
SHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQR
NMAQYFKKVLGDTLLTKPVEISADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSMMYSENDISNSIKNGILYLEDPVNHEWYPHYFVLT
SSKIYYSEETSSDQGNEDEEEPKEVSSSTELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFWRNG
KVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQTNAHESKEWYHASLTRAQAEHMLMRVPRDGAFLV
RKRNEPNSYAISFRAEGKIKHCRVQQEGQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNPGFY
VEANPMPTFKCAVKALFDYKAQREDELTFIKSAIIQNVEKQEGGWWRGDYGGKKQLWFPSNYVEEMVNPVALEPEREHLDENSPLGDLLR
GVLDVPACQIAIRPEGKNNRLFVFSISMASVAHWSLDVAADSQEELQDWVKKIREVAQTADARDCDQIHVDDVSSDDNGQDLSTYNFSAD
GFHSSAPGANLCLGSGVHGGVDWMRKLAFRYRRVKEMYNTYKNNVGGKESCFERIMQRFGRKAVYVVIGDGVEEEQGAKKHNMPFWRISC

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Fusion Gene PPI Analysis for PLCG1-EYA2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PLCG1-EYA2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PLCG1-EYA2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource