FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:PLCZ1-PTHLH (FusionGDB2 ID:66077)

Fusion Gene Summary for PLCZ1-PTHLH

check button Fusion gene summary
Fusion gene informationFusion gene name: PLCZ1-PTHLH
Fusion gene ID: 66077
HgeneTgene
Gene symbol

PLCZ1

PTHLH

Gene ID

89869

5744

Gene namephospholipase C zeta 1parathyroid hormone like hormone
SynonymsNYD-SP27|PLC-zeta-1|PLCzeta|SPGF17BDE2|HHM|PLP|PTHR|PTHRP
Cytomap

12p12.3

12p11.22

Type of geneprotein-codingprotein-coding
Description1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1PI-phospholipase C zeta 1phosphoinositide phospholipase C-zeta-1testicular tissue protein Li 145testis-development related NYD-SP27parathyroid hormone-related proteinPTH-rPPTH-related proteinosteostatinparathyroid hormone-like hormone preproproteinparathyroid hormone-like related protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000266505, ENST00000435379, 
ENST00000447925, ENST00000538330, 
ENST00000539875, ENST00000541695, 
ENST00000534932, ENST00000542762, 
ENST00000201015, ENST00000354417, 
ENST00000395868, ENST00000535992, 
ENST00000538310, ENST00000395872, 
ENST00000539239, ENST00000545234, 
Fusion gene scores* DoF score1 X 1 X 1=11 X 1 X 1=1
# samples 11
** MAII scorelog2(1/1*10)=3.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: PLCZ1 [Title/Abstract] AND PTHLH [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPLCZ1(18847844)-PTHLH(28111501), # samples:2
Anticipated loss of major functional domain due to fusion event.PLCZ1-PTHLH seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
PLCZ1-PTHLH seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePLCZ1

GO:0060470

positive regulation of cytosolic calcium ion concentration involved in egg activation

18322275|26116451

TgenePTHLH

GO:0001501

skeletal system development

9008714

TgenePTHLH

GO:0007189

adenylate cyclase-activating G protein-coupled receptor signaling pathway

9832460

TgenePTHLH

GO:0010468

regulation of gene expression

90087

TgenePTHLH

GO:0032331

negative regulation of chondrocyte differentiation

90087

TgenePTHLH

GO:0061182

negative regulation of chondrocyte development

90087


check buttonFusion gene breakpoints across PLCZ1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PTHLH (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AR-A1AR-01APLCZ1chr12

18847844

-PTHLHchr12

28111501

-


Top

Fusion Gene ORF analysis for PLCZ1-PTHLH

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000266505ENST00000201015PLCZ1chr12

18847844

-PTHLHchr12

28111501

-
5CDS-intronENST00000266505ENST00000354417PLCZ1chr12

18847844

-PTHLHchr12

28111501

-
5CDS-intronENST00000266505ENST00000395868PLCZ1chr12

18847844

-PTHLHchr12

28111501

-
5CDS-intronENST00000266505ENST00000535992PLCZ1chr12

18847844

-PTHLHchr12

28111501

-
5CDS-intronENST00000266505ENST00000538310PLCZ1chr12

18847844

-PTHLHchr12

28111501

-
5CDS-intronENST00000435379ENST00000201015PLCZ1chr12

18847844

-PTHLHchr12

28111501

-
5CDS-intronENST00000435379ENST00000354417PLCZ1chr12

18847844

-PTHLHchr12

28111501

-
5CDS-intronENST00000435379ENST00000395868PLCZ1chr12

18847844

-PTHLHchr12

28111501

-
5CDS-intronENST00000435379ENST00000535992PLCZ1chr12

18847844

-PTHLHchr12

28111501

-
5CDS-intronENST00000435379ENST00000538310PLCZ1chr12

18847844

-PTHLHchr12

28111501

-
5CDS-intronENST00000447925ENST00000201015PLCZ1chr12

18847844

-PTHLHchr12

28111501

-
5CDS-intronENST00000447925ENST00000354417PLCZ1chr12

18847844

-PTHLHchr12

28111501

-
5CDS-intronENST00000447925ENST00000395868PLCZ1chr12

18847844

-PTHLHchr12

28111501

-
5CDS-intronENST00000447925ENST00000535992PLCZ1chr12

18847844

-PTHLHchr12

28111501

-
5CDS-intronENST00000447925ENST00000538310PLCZ1chr12

18847844

-PTHLHchr12

28111501

-
5CDS-intronENST00000538330ENST00000201015PLCZ1chr12

18847844

-PTHLHchr12

28111501

-
5CDS-intronENST00000538330ENST00000354417PLCZ1chr12

18847844

-PTHLHchr12

28111501

-
5CDS-intronENST00000538330ENST00000395868PLCZ1chr12

18847844

-PTHLHchr12

28111501

-
5CDS-intronENST00000538330ENST00000535992PLCZ1chr12

18847844

-PTHLHchr12

28111501

-
5CDS-intronENST00000538330ENST00000538310PLCZ1chr12

18847844

-PTHLHchr12

28111501

-
5CDS-intronENST00000539875ENST00000201015PLCZ1chr12

18847844

-PTHLHchr12

28111501

-
5CDS-intronENST00000539875ENST00000354417PLCZ1chr12

18847844

-PTHLHchr12

28111501

-
5CDS-intronENST00000539875ENST00000395868PLCZ1chr12

18847844

-PTHLHchr12

28111501

-
5CDS-intronENST00000539875ENST00000535992PLCZ1chr12

18847844

-PTHLHchr12

28111501

-
5CDS-intronENST00000539875ENST00000538310PLCZ1chr12

18847844

-PTHLHchr12

28111501

-
5CDS-intronENST00000541695ENST00000201015PLCZ1chr12

18847844

-PTHLHchr12

28111501

-
5CDS-intronENST00000541695ENST00000354417PLCZ1chr12

18847844

-PTHLHchr12

28111501

-
5CDS-intronENST00000541695ENST00000395868PLCZ1chr12

18847844

-PTHLHchr12

28111501

-
5CDS-intronENST00000541695ENST00000535992PLCZ1chr12

18847844

-PTHLHchr12

28111501

-
5CDS-intronENST00000541695ENST00000538310PLCZ1chr12

18847844

-PTHLHchr12

28111501

-
Frame-shiftENST00000539875ENST00000395872PLCZ1chr12

18847844

-PTHLHchr12

28111501

-
Frame-shiftENST00000539875ENST00000539239PLCZ1chr12

18847844

-PTHLHchr12

28111501

-
Frame-shiftENST00000539875ENST00000545234PLCZ1chr12

18847844

-PTHLHchr12

28111501

-
In-frameENST00000266505ENST00000395872PLCZ1chr12

18847844

-PTHLHchr12

28111501

-
In-frameENST00000266505ENST00000539239PLCZ1chr12

18847844

-PTHLHchr12

28111501

-
In-frameENST00000266505ENST00000545234PLCZ1chr12

18847844

-PTHLHchr12

28111501

-
In-frameENST00000435379ENST00000395872PLCZ1chr12

18847844

-PTHLHchr12

28111501

-
In-frameENST00000435379ENST00000539239PLCZ1chr12

18847844

-PTHLHchr12

28111501

-
In-frameENST00000435379ENST00000545234PLCZ1chr12

18847844

-PTHLHchr12

28111501

-
In-frameENST00000447925ENST00000395872PLCZ1chr12

18847844

-PTHLHchr12

28111501

-
In-frameENST00000447925ENST00000539239PLCZ1chr12

18847844

-PTHLHchr12

28111501

-
In-frameENST00000447925ENST00000545234PLCZ1chr12

18847844

-PTHLHchr12

28111501

-
In-frameENST00000538330ENST00000395872PLCZ1chr12

18847844

-PTHLHchr12

28111501

-
In-frameENST00000538330ENST00000539239PLCZ1chr12

18847844

-PTHLHchr12

28111501

-
In-frameENST00000538330ENST00000545234PLCZ1chr12

18847844

-PTHLHchr12

28111501

-
In-frameENST00000541695ENST00000395872PLCZ1chr12

18847844

-PTHLHchr12

28111501

-
In-frameENST00000541695ENST00000539239PLCZ1chr12

18847844

-PTHLHchr12

28111501

-
In-frameENST00000541695ENST00000545234PLCZ1chr12

18847844

-PTHLHchr12

28111501

-
intron-3CDSENST00000534932ENST00000395872PLCZ1chr12

18847844

-PTHLHchr12

28111501

-
intron-3CDSENST00000534932ENST00000539239PLCZ1chr12

18847844

-PTHLHchr12

28111501

-
intron-3CDSENST00000534932ENST00000545234PLCZ1chr12

18847844

-PTHLHchr12

28111501

-
intron-3CDSENST00000542762ENST00000395872PLCZ1chr12

18847844

-PTHLHchr12

28111501

-
intron-3CDSENST00000542762ENST00000539239PLCZ1chr12

18847844

-PTHLHchr12

28111501

-
intron-3CDSENST00000542762ENST00000545234PLCZ1chr12

18847844

-PTHLHchr12

28111501

-
intron-intronENST00000534932ENST00000201015PLCZ1chr12

18847844

-PTHLHchr12

28111501

-
intron-intronENST00000534932ENST00000354417PLCZ1chr12

18847844

-PTHLHchr12

28111501

-
intron-intronENST00000534932ENST00000395868PLCZ1chr12

18847844

-PTHLHchr12

28111501

-
intron-intronENST00000534932ENST00000535992PLCZ1chr12

18847844

-PTHLHchr12

28111501

-
intron-intronENST00000534932ENST00000538310PLCZ1chr12

18847844

-PTHLHchr12

28111501

-
intron-intronENST00000542762ENST00000201015PLCZ1chr12

18847844

-PTHLHchr12

28111501

-
intron-intronENST00000542762ENST00000354417PLCZ1chr12

18847844

-PTHLHchr12

28111501

-
intron-intronENST00000542762ENST00000395868PLCZ1chr12

18847844

-PTHLHchr12

28111501

-
intron-intronENST00000542762ENST00000535992PLCZ1chr12

18847844

-PTHLHchr12

28111501

-
intron-intronENST00000542762ENST00000538310PLCZ1chr12

18847844

-PTHLHchr12

28111501

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000447925PLCZ1chr1218847844-ENST00000395872PTHLHchr1228111501-221017252641823519
ENST00000447925PLCZ1chr1218847844-ENST00000539239PTHLHchr1228111501-202417252641823519
ENST00000447925PLCZ1chr1218847844-ENST00000545234PTHLHchr1228111501-187417252641823519
ENST00000435379PLCZ1chr1218847844-ENST00000395872PTHLHchr1228111501-163111462641244326
ENST00000435379PLCZ1chr1218847844-ENST00000539239PTHLHchr1228111501-144511462641244326
ENST00000435379PLCZ1chr1218847844-ENST00000545234PTHLHchr1228111501-129511462641244326
ENST00000266505PLCZ1chr1218847844-ENST00000395872PTHLHchr1228111501-221017252641823519
ENST00000266505PLCZ1chr1218847844-ENST00000539239PTHLHchr1228111501-202417252641823519
ENST00000266505PLCZ1chr1218847844-ENST00000545234PTHLHchr1228111501-187417252641823519
ENST00000538330PLCZ1chr1218847844-ENST00000395872PTHLHchr1228111501-167411893821287301
ENST00000538330PLCZ1chr1218847844-ENST00000539239PTHLHchr1228111501-148811893821287301
ENST00000538330PLCZ1chr1218847844-ENST00000545234PTHLHchr1228111501-133811893821287301
ENST00000541695PLCZ1chr1218847844-ENST00000395872PTHLHchr1228111501-15601075251173382
ENST00000541695PLCZ1chr1218847844-ENST00000539239PTHLHchr1228111501-13741075251173382
ENST00000541695PLCZ1chr1218847844-ENST00000545234PTHLHchr1228111501-12241075251173382

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000447925ENST00000395872PLCZ1chr1218847844-PTHLHchr1228111501-0.0010844940.99891555
ENST00000447925ENST00000539239PLCZ1chr1218847844-PTHLHchr1228111501-0.0014335640.99856645
ENST00000447925ENST00000545234PLCZ1chr1218847844-PTHLHchr1228111501-0.0020363790.99796367
ENST00000435379ENST00000395872PLCZ1chr1218847844-PTHLHchr1228111501-0.0005024780.99949753
ENST00000435379ENST00000539239PLCZ1chr1218847844-PTHLHchr1228111501-0.0006360720.99936396
ENST00000435379ENST00000545234PLCZ1chr1218847844-PTHLHchr1228111501-0.0011725010.9988275
ENST00000266505ENST00000395872PLCZ1chr1218847844-PTHLHchr1228111501-0.0010844940.99891555
ENST00000266505ENST00000539239PLCZ1chr1218847844-PTHLHchr1228111501-0.0014335640.99856645
ENST00000266505ENST00000545234PLCZ1chr1218847844-PTHLHchr1228111501-0.0020363790.99796367
ENST00000538330ENST00000395872PLCZ1chr1218847844-PTHLHchr1228111501-0.0002146390.99978536
ENST00000538330ENST00000539239PLCZ1chr1218847844-PTHLHchr1228111501-0.000333370.9996667
ENST00000538330ENST00000545234PLCZ1chr1218847844-PTHLHchr1228111501-0.0004571710.99954283
ENST00000541695ENST00000395872PLCZ1chr1218847844-PTHLHchr1228111501-0.0001449160.99985504
ENST00000541695ENST00000539239PLCZ1chr1218847844-PTHLHchr1228111501-0.000196990.999803
ENST00000541695ENST00000545234PLCZ1chr1218847844-PTHLHchr1228111501-0.0002957620.9997042

Top

Fusion Genomic Features for PLCZ1-PTHLH


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for PLCZ1-PTHLH


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:18847844/chr12:28111501)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePLCZ1chr12:18847844chr12:28111501ENST00000266505-1215155_299487609.0DomainPI-PLC X-box
HgenePLCZ1chr12:18847844chr12:28111501ENST00000266505-1215349_465487609.0DomainPI-PLC Y-box
HgenePLCZ1chr12:18847844chr12:28111501ENST00000266505-121535_70487609.0DomainEF-hand
HgenePLCZ1chr12:18847844chr12:28111501ENST00000539875-81135_70294416.0DomainEF-hand
TgenePTHLHchr12:18847844chr12:28111501ENST0000020101504108_1290176.0MotifNuclear localization signal
TgenePTHLHchr12:18847844chr12:28111501ENST0000035441705108_1290210.0MotifNuclear localization signal
TgenePTHLHchr12:18847844chr12:28111501ENST0000039586803108_1290176.0MotifNuclear localization signal
TgenePTHLHchr12:18847844chr12:28111501ENST0000053599203108_1290176.0MotifNuclear localization signal
TgenePTHLHchr12:18847844chr12:28111501ENST0000053831003108_1290210.0MotifNuclear localization signal
TgenePTHLHchr12:18847844chr12:28111501ENST000002010150457_680176.0RegionNote=Important for receptor binding
TgenePTHLHchr12:18847844chr12:28111501ENST000003544170557_680210.0RegionNote=Important for receptor binding
TgenePTHLHchr12:18847844chr12:28111501ENST000003958680357_680176.0RegionNote=Important for receptor binding
TgenePTHLHchr12:18847844chr12:28111501ENST000005359920357_680176.0RegionNote=Important for receptor binding
TgenePTHLHchr12:18847844chr12:28111501ENST000005383100357_680210.0RegionNote=Important for receptor binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePLCZ1chr12:18847844chr12:28111501ENST00000266505-1215465_589487609.0DomainC2
HgenePLCZ1chr12:18847844chr12:28111501ENST00000539875-811155_299294416.0DomainPI-PLC X-box
HgenePLCZ1chr12:18847844chr12:28111501ENST00000539875-811349_465294416.0DomainPI-PLC Y-box
HgenePLCZ1chr12:18847844chr12:28111501ENST00000539875-811465_589294416.0DomainC2
TgenePTHLHchr12:18847844chr12:28111501ENST0000039587235108_129174178.0MotifNuclear localization signal
TgenePTHLHchr12:18847844chr12:28111501ENST0000053923913108_129174178.0MotifNuclear localization signal
TgenePTHLHchr12:18847844chr12:28111501ENST0000054523446108_129174178.0MotifNuclear localization signal
TgenePTHLHchr12:18847844chr12:28111501ENST000003958723557_68174178.0RegionNote=Important for receptor binding
TgenePTHLHchr12:18847844chr12:28111501ENST000005392391357_68174178.0RegionNote=Important for receptor binding
TgenePTHLHchr12:18847844chr12:28111501ENST000005452344657_68174178.0RegionNote=Important for receptor binding


Top

Fusion Gene Sequence for PLCZ1-PTHLH


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>66077_66077_1_PLCZ1-PTHLH_PLCZ1_chr12_18847844_ENST00000266505_PTHLH_chr12_28111501_ENST00000395872_length(transcript)=2210nt_BP=1725nt
ACAATGGGAATTCAGACCAAAAGGAAAAAATGACAGTCACCTGACAGTGTGGTGCCCAGCCAACCAGCTATACCTCTTTTGAAGATTTTA
AGAACTTAGCCTCCTGAACAGTCTTCTTCGAAAGTGAAAAGTGGTAACAGCTGATGAGTATCAAGAAATTATTTTCTGCAAAGGGGCAGA
GTTAATTGTATTTGGAACCCATGACAGCACCTACTGGGGAAAGACTTCTAAGTGAGGAGAAACGGCTCTACAGGTCATGAAACTATGGAA
ATGAGATGGTTTTTGTCAAAGATTCAGGATGACTTCAGAGGTGGAAAAATTAACCTAGAAAAAACTCAGAGGTTACTTGAAAAATTAGAT
ATTCGGTGCAGTTATATTCATGTGAAACAGATTTTTAAGGACAATGACAGGCTGAAACAAGGAAGAATCACCATAGAAGAATTTAGAGCA
ATTTATCGAATTATCACGCACAGAGAAGAAATTATTGAGATTTTCAACACATATTCTGAAAACCGGAAAATTCTTTTAGCAAGTAATCTG
GCTCAATTTCTGACACAAGAACAATATGCAGCTGAGATGAGTAAAGCTATTGCTTTTGAGATCATTCAGAAATACGAGCCTATCGAAGAA
GTTAGGAAAGCACACCAAATGTCATTAGAAGGTTTTACAAGATACATGGATTCACGTGAATGTCTACTGTTTAAAAATGAATGTAGAAAA
GTTTATCAAGATATGACTCATCCATTAAATGATTATTTTATTTCATCTTCACATAACACATATTTGGTATCTGATCAATTATTGGGACCA
AGTGACCTTTGGGGATATGTAAGTGCCCTTGTGAAAGGATGCCGTTGTTTGGAGATTGACTGCTGGGATGGAGCACAAAATGAACCTGTT
GTATATCATGGCTACACACTCACAAGCAAACTTCTGTTTAAAACTGTTATCCAAGCTATACACAAGTATGCATTCATGACATCTGACTAC
CCAGTGGTGCTCTCTTTAGAAAATCACTGCTCCACTGCCCAACAAGAAGTAATGGCAGACAATTTGCAGGCTACTTTTGGAGAGTCCTTG
CTTTCTGATATGCTTGATGATTTTCCTGATACTCTACCATCACCAGAGGCACTAAAATTCAAAATATTAGTTAAAAATAAGAAAATAGGA
ACCTTAAAGGAAACCCATGAAAGAAAAGGTTCTGATAAGCGTGGAGACAATCAAGACAAGGAAACAGGGGTAAAAAAGTTACCTGGAGTA
ATGCTTTTCAAGAAAAAGAAGACCAGGAAGCTAAAAATTGCTCTGGCCTTATCTGATCTTGTCATTTATACGAAAGCTGAGAAATTCAAA
AGCTTTCAACATTCAAGATTATATCAGCAATTTAATGAAAATAATTCTATTGGGGAGACACAAGCCCGAAAACTTTCAAAATTGCGAGTC
CATGAGTTTATTTTTCACACCAGGAAGTTCATTACCAGAATATATCCCAAAGCAACAAGAGCAGACTCTTCTAATTTTAATCCCCAAGAA
TTTTGGAATATAGGTTGTCAAATGGTGGCTTTAAATTTCCAGACCCCTGGTCTGCCCATGGATCTGCAAAATGGGAAATTTTTGGATAAT
GGTGGTTCTGGATATATTTTGAAACCACATTTCTTAAGAGAGAGTAAATCATACTTTAACCCAAGTAACATAAAAGAGGGTATGCCAATT
ACACTTACAATAAGGGAGGCATTGAAATTTTCAGCAGAGACCTTCCAAGGACATATTGCAGGATTCTGTAATAGTGAACATATGGAAAGT
ATTAGAAATATTTATTGTCTGTAAATACTGTAAATGCATTGGAATAAAACTGTCTCCCCCATTGCTCTATGAAACTGCACATTGGTCATT
GTGAATATTTTTTTTTTGCCAAGGCTAATCCAATTATTATTATCACATTTACCATAATTTATTTTGTCCATTGATGTATTTATTTTGTAA
ATGTATCTTGGTGCTGCTGAATTTCTATATTTTTTGTAACATAATGCACTTTAGATATACATATCAAGTATGTTGATAAATGACACAATG
AAGTGTCTCTATTTTGTGGTTGATTTTAATGAATGCCTAAATATAATTATCCAAATTGATTTTCCTTTGTGCATGTAAAAATAACAGTAT

>66077_66077_1_PLCZ1-PTHLH_PLCZ1_chr12_18847844_ENST00000266505_PTHLH_chr12_28111501_ENST00000395872_length(amino acids)=519AA_BP=487
MEMRWFLSKIQDDFRGGKINLEKTQRLLEKLDIRCSYIHVKQIFKDNDRLKQGRITIEEFRAIYRIITHREEIIEIFNTYSENRKILLAS
NLAQFLTQEQYAAEMSKAIAFEIIQKYEPIEEVRKAHQMSLEGFTRYMDSRECLLFKNECRKVYQDMTHPLNDYFISSSHNTYLVSDQLL
GPSDLWGYVSALVKGCRCLEIDCWDGAQNEPVVYHGYTLTSKLLFKTVIQAIHKYAFMTSDYPVVLSLENHCSTAQQEVMADNLQATFGE
SLLSDMLDDFPDTLPSPEALKFKILVKNKKIGTLKETHERKGSDKRGDNQDKETGVKKLPGVMLFKKKKTRKLKIALALSDLVIYTKAEK
FKSFQHSRLYQQFNENNSIGETQARKLSKLRVHEFIFHTRKFITRIYPKATRADSSNFNPQEFWNIGCQMVALNFQTPGLPMDLQNGKFL

--------------------------------------------------------------
>66077_66077_2_PLCZ1-PTHLH_PLCZ1_chr12_18847844_ENST00000266505_PTHLH_chr12_28111501_ENST00000539239_length(transcript)=2024nt_BP=1725nt
ACAATGGGAATTCAGACCAAAAGGAAAAAATGACAGTCACCTGACAGTGTGGTGCCCAGCCAACCAGCTATACCTCTTTTGAAGATTTTA
AGAACTTAGCCTCCTGAACAGTCTTCTTCGAAAGTGAAAAGTGGTAACAGCTGATGAGTATCAAGAAATTATTTTCTGCAAAGGGGCAGA
GTTAATTGTATTTGGAACCCATGACAGCACCTACTGGGGAAAGACTTCTAAGTGAGGAGAAACGGCTCTACAGGTCATGAAACTATGGAA
ATGAGATGGTTTTTGTCAAAGATTCAGGATGACTTCAGAGGTGGAAAAATTAACCTAGAAAAAACTCAGAGGTTACTTGAAAAATTAGAT
ATTCGGTGCAGTTATATTCATGTGAAACAGATTTTTAAGGACAATGACAGGCTGAAACAAGGAAGAATCACCATAGAAGAATTTAGAGCA
ATTTATCGAATTATCACGCACAGAGAAGAAATTATTGAGATTTTCAACACATATTCTGAAAACCGGAAAATTCTTTTAGCAAGTAATCTG
GCTCAATTTCTGACACAAGAACAATATGCAGCTGAGATGAGTAAAGCTATTGCTTTTGAGATCATTCAGAAATACGAGCCTATCGAAGAA
GTTAGGAAAGCACACCAAATGTCATTAGAAGGTTTTACAAGATACATGGATTCACGTGAATGTCTACTGTTTAAAAATGAATGTAGAAAA
GTTTATCAAGATATGACTCATCCATTAAATGATTATTTTATTTCATCTTCACATAACACATATTTGGTATCTGATCAATTATTGGGACCA
AGTGACCTTTGGGGATATGTAAGTGCCCTTGTGAAAGGATGCCGTTGTTTGGAGATTGACTGCTGGGATGGAGCACAAAATGAACCTGTT
GTATATCATGGCTACACACTCACAAGCAAACTTCTGTTTAAAACTGTTATCCAAGCTATACACAAGTATGCATTCATGACATCTGACTAC
CCAGTGGTGCTCTCTTTAGAAAATCACTGCTCCACTGCCCAACAAGAAGTAATGGCAGACAATTTGCAGGCTACTTTTGGAGAGTCCTTG
CTTTCTGATATGCTTGATGATTTTCCTGATACTCTACCATCACCAGAGGCACTAAAATTCAAAATATTAGTTAAAAATAAGAAAATAGGA
ACCTTAAAGGAAACCCATGAAAGAAAAGGTTCTGATAAGCGTGGAGACAATCAAGACAAGGAAACAGGGGTAAAAAAGTTACCTGGAGTA
ATGCTTTTCAAGAAAAAGAAGACCAGGAAGCTAAAAATTGCTCTGGCCTTATCTGATCTTGTCATTTATACGAAAGCTGAGAAATTCAAA
AGCTTTCAACATTCAAGATTATATCAGCAATTTAATGAAAATAATTCTATTGGGGAGACACAAGCCCGAAAACTTTCAAAATTGCGAGTC
CATGAGTTTATTTTTCACACCAGGAAGTTCATTACCAGAATATATCCCAAAGCAACAAGAGCAGACTCTTCTAATTTTAATCCCCAAGAA
TTTTGGAATATAGGTTGTCAAATGGTGGCTTTAAATTTCCAGACCCCTGGTCTGCCCATGGATCTGCAAAATGGGAAATTTTTGGATAAT
GGTGGTTCTGGATATATTTTGAAACCACATTTCTTAAGAGAGAGTAAATCATACTTTAACCCAAGTAACATAAAAGAGGGTATGCCAATT
ACACTTACAATAAGGGAGGCATTGAAATTTTCAGCAGAGACCTTCCAAGGACATATTGCAGGATTCTGTAATAGTGAACATATGGAAAGT
ATTAGAAATATTTATTGTCTGTAAATACTGTAAATGCATTGGAATAAAACTGTCTCCCCCATTGCTCTATGAAACTGCACATTGGTCATT
GTGAATATTTTTTTTTTGCCAAGGCTAATCCAATTATTATTATCACATTTACCATAATTTATTTTGTCCATTGATGTATTTATTTTGTAA

>66077_66077_2_PLCZ1-PTHLH_PLCZ1_chr12_18847844_ENST00000266505_PTHLH_chr12_28111501_ENST00000539239_length(amino acids)=519AA_BP=487
MEMRWFLSKIQDDFRGGKINLEKTQRLLEKLDIRCSYIHVKQIFKDNDRLKQGRITIEEFRAIYRIITHREEIIEIFNTYSENRKILLAS
NLAQFLTQEQYAAEMSKAIAFEIIQKYEPIEEVRKAHQMSLEGFTRYMDSRECLLFKNECRKVYQDMTHPLNDYFISSSHNTYLVSDQLL
GPSDLWGYVSALVKGCRCLEIDCWDGAQNEPVVYHGYTLTSKLLFKTVIQAIHKYAFMTSDYPVVLSLENHCSTAQQEVMADNLQATFGE
SLLSDMLDDFPDTLPSPEALKFKILVKNKKIGTLKETHERKGSDKRGDNQDKETGVKKLPGVMLFKKKKTRKLKIALALSDLVIYTKAEK
FKSFQHSRLYQQFNENNSIGETQARKLSKLRVHEFIFHTRKFITRIYPKATRADSSNFNPQEFWNIGCQMVALNFQTPGLPMDLQNGKFL

--------------------------------------------------------------
>66077_66077_3_PLCZ1-PTHLH_PLCZ1_chr12_18847844_ENST00000266505_PTHLH_chr12_28111501_ENST00000545234_length(transcript)=1874nt_BP=1725nt
ACAATGGGAATTCAGACCAAAAGGAAAAAATGACAGTCACCTGACAGTGTGGTGCCCAGCCAACCAGCTATACCTCTTTTGAAGATTTTA
AGAACTTAGCCTCCTGAACAGTCTTCTTCGAAAGTGAAAAGTGGTAACAGCTGATGAGTATCAAGAAATTATTTTCTGCAAAGGGGCAGA
GTTAATTGTATTTGGAACCCATGACAGCACCTACTGGGGAAAGACTTCTAAGTGAGGAGAAACGGCTCTACAGGTCATGAAACTATGGAA
ATGAGATGGTTTTTGTCAAAGATTCAGGATGACTTCAGAGGTGGAAAAATTAACCTAGAAAAAACTCAGAGGTTACTTGAAAAATTAGAT
ATTCGGTGCAGTTATATTCATGTGAAACAGATTTTTAAGGACAATGACAGGCTGAAACAAGGAAGAATCACCATAGAAGAATTTAGAGCA
ATTTATCGAATTATCACGCACAGAGAAGAAATTATTGAGATTTTCAACACATATTCTGAAAACCGGAAAATTCTTTTAGCAAGTAATCTG
GCTCAATTTCTGACACAAGAACAATATGCAGCTGAGATGAGTAAAGCTATTGCTTTTGAGATCATTCAGAAATACGAGCCTATCGAAGAA
GTTAGGAAAGCACACCAAATGTCATTAGAAGGTTTTACAAGATACATGGATTCACGTGAATGTCTACTGTTTAAAAATGAATGTAGAAAA
GTTTATCAAGATATGACTCATCCATTAAATGATTATTTTATTTCATCTTCACATAACACATATTTGGTATCTGATCAATTATTGGGACCA
AGTGACCTTTGGGGATATGTAAGTGCCCTTGTGAAAGGATGCCGTTGTTTGGAGATTGACTGCTGGGATGGAGCACAAAATGAACCTGTT
GTATATCATGGCTACACACTCACAAGCAAACTTCTGTTTAAAACTGTTATCCAAGCTATACACAAGTATGCATTCATGACATCTGACTAC
CCAGTGGTGCTCTCTTTAGAAAATCACTGCTCCACTGCCCAACAAGAAGTAATGGCAGACAATTTGCAGGCTACTTTTGGAGAGTCCTTG
CTTTCTGATATGCTTGATGATTTTCCTGATACTCTACCATCACCAGAGGCACTAAAATTCAAAATATTAGTTAAAAATAAGAAAATAGGA
ACCTTAAAGGAAACCCATGAAAGAAAAGGTTCTGATAAGCGTGGAGACAATCAAGACAAGGAAACAGGGGTAAAAAAGTTACCTGGAGTA
ATGCTTTTCAAGAAAAAGAAGACCAGGAAGCTAAAAATTGCTCTGGCCTTATCTGATCTTGTCATTTATACGAAAGCTGAGAAATTCAAA
AGCTTTCAACATTCAAGATTATATCAGCAATTTAATGAAAATAATTCTATTGGGGAGACACAAGCCCGAAAACTTTCAAAATTGCGAGTC
CATGAGTTTATTTTTCACACCAGGAAGTTCATTACCAGAATATATCCCAAAGCAACAAGAGCAGACTCTTCTAATTTTAATCCCCAAGAA
TTTTGGAATATAGGTTGTCAAATGGTGGCTTTAAATTTCCAGACCCCTGGTCTGCCCATGGATCTGCAAAATGGGAAATTTTTGGATAAT
GGTGGTTCTGGATATATTTTGAAACCACATTTCTTAAGAGAGAGTAAATCATACTTTAACCCAAGTAACATAAAAGAGGGTATGCCAATT
ACACTTACAATAAGGGAGGCATTGAAATTTTCAGCAGAGACCTTCCAAGGACATATTGCAGGATTCTGTAATAGTGAACATATGGAAAGT

>66077_66077_3_PLCZ1-PTHLH_PLCZ1_chr12_18847844_ENST00000266505_PTHLH_chr12_28111501_ENST00000545234_length(amino acids)=519AA_BP=487
MEMRWFLSKIQDDFRGGKINLEKTQRLLEKLDIRCSYIHVKQIFKDNDRLKQGRITIEEFRAIYRIITHREEIIEIFNTYSENRKILLAS
NLAQFLTQEQYAAEMSKAIAFEIIQKYEPIEEVRKAHQMSLEGFTRYMDSRECLLFKNECRKVYQDMTHPLNDYFISSSHNTYLVSDQLL
GPSDLWGYVSALVKGCRCLEIDCWDGAQNEPVVYHGYTLTSKLLFKTVIQAIHKYAFMTSDYPVVLSLENHCSTAQQEVMADNLQATFGE
SLLSDMLDDFPDTLPSPEALKFKILVKNKKIGTLKETHERKGSDKRGDNQDKETGVKKLPGVMLFKKKKTRKLKIALALSDLVIYTKAEK
FKSFQHSRLYQQFNENNSIGETQARKLSKLRVHEFIFHTRKFITRIYPKATRADSSNFNPQEFWNIGCQMVALNFQTPGLPMDLQNGKFL

--------------------------------------------------------------
>66077_66077_4_PLCZ1-PTHLH_PLCZ1_chr12_18847844_ENST00000435379_PTHLH_chr12_28111501_ENST00000395872_length(transcript)=1631nt_BP=1146nt
ACAATGGGAATTCAGACCAAAAGGAAAAAATGACAGTCACCTGACAGTGTGGTGCCCAGCCAACCAGCTATACCTCTTTTGAAGATTTTA
AGAACTTAGCCTCCTGAACAGTCTTCTTCGAAAGTGAAAAGTGGTAACAGCTGATGAGTATCAAGAAATTATTTTCTGCAAAGGGGCAGA
GTTAATTGTATTTGGAACCCATGACAGCACCTACTGGGGAAAGACTTCTAAGTGAGGAGAAACGGCTCTACAGGTCATGAAACTATGGAA
ATGAGATGGTTTTTGTCAAAGATTCAGGATGACTTCAGAGGTGGAAAAATTAACCTAGAAAAAACTCAGAGGTTACTTGAAAAATTAGAT
ATTCGGTGCAGTTATATTCATGTGAAACAGATTTTTAAGACATCTGACTACCCAGTGGTGCTCTCTTTAGAAAATCACTGCTCCACTGCC
CAACAAGAAGTAATGGCAGACAATTTGCAGGCTACTTTTGGAGAGTCCTTGCTTTCTGATATGCTTGATGATTTTCCTGATACTCTACCA
TCACCAGAGGCACTAAAATTCAAAATATTAGTTAAAAATAAGAAAATAGGAACCTTAAAGGAAACCCATGAAAGAAAAGGTTCTGATAAG
CGTGGAGACAATCAAGACAAGGAAACAGGGGTAAAAAAGTTACCTGGAGTAATGCTTTTCAAGAAAAAGAAGACCAGGAAGCTAAAAATT
GCTCTGGCCTTATCTGATCTTGTCATTTATACGAAAGCTGAGAAATTCAAAAGCTTTCAACATTCAAGATTATATCAGCAATTTAATGAA
AATAATTCTATTGGGGAGACACAAGCCCGAAAACTTTCAAAATTGCGAGTCCATGAGTTTATTTTTCACACCAGGAAGTTCATTACCAGA
ATATATCCCAAAGCAACAAGAGCAGACTCTTCTAATTTTAATCCCCAAGAATTTTGGAATATAGGTTGTCAAATGGTGGCTTTAAATTTC
CAGACCCCTGGTCTGCCCATGGATCTGCAAAATGGGAAATTTTTGGATAATGGTGGTTCTGGATATATTTTGAAACCACATTTCTTAAGA
GAGAGTAAATCATACTTTAACCCAAGTAACATAAAAGAGGGTATGCCAATTACACTTACAATAAGGGAGGCATTGAAATTTTCAGCAGAG
ACCTTCCAAGGACATATTGCAGGATTCTGTAATAGTGAACATATGGAAAGTATTAGAAATATTTATTGTCTGTAAATACTGTAAATGCAT
TGGAATAAAACTGTCTCCCCCATTGCTCTATGAAACTGCACATTGGTCATTGTGAATATTTTTTTTTTGCCAAGGCTAATCCAATTATTA
TTATCACATTTACCATAATTTATTTTGTCCATTGATGTATTTATTTTGTAAATGTATCTTGGTGCTGCTGAATTTCTATATTTTTTGTAA
CATAATGCACTTTAGATATACATATCAAGTATGTTGATAAATGACACAATGAAGTGTCTCTATTTTGTGGTTGATTTTAATGAATGCCTA
AATATAATTATCCAAATTGATTTTCCTTTGTGCATGTAAAAATAACAGTATTTTAAATTTGTAAAGAATGTCTAATAAAATATAATCTAA

>66077_66077_4_PLCZ1-PTHLH_PLCZ1_chr12_18847844_ENST00000435379_PTHLH_chr12_28111501_ENST00000395872_length(amino acids)=326AA_BP=294
MEMRWFLSKIQDDFRGGKINLEKTQRLLEKLDIRCSYIHVKQIFKTSDYPVVLSLENHCSTAQQEVMADNLQATFGESLLSDMLDDFPDT
LPSPEALKFKILVKNKKIGTLKETHERKGSDKRGDNQDKETGVKKLPGVMLFKKKKTRKLKIALALSDLVIYTKAEKFKSFQHSRLYQQF
NENNSIGETQARKLSKLRVHEFIFHTRKFITRIYPKATRADSSNFNPQEFWNIGCQMVALNFQTPGLPMDLQNGKFLDNGGSGYILKPHF

--------------------------------------------------------------
>66077_66077_5_PLCZ1-PTHLH_PLCZ1_chr12_18847844_ENST00000435379_PTHLH_chr12_28111501_ENST00000539239_length(transcript)=1445nt_BP=1146nt
ACAATGGGAATTCAGACCAAAAGGAAAAAATGACAGTCACCTGACAGTGTGGTGCCCAGCCAACCAGCTATACCTCTTTTGAAGATTTTA
AGAACTTAGCCTCCTGAACAGTCTTCTTCGAAAGTGAAAAGTGGTAACAGCTGATGAGTATCAAGAAATTATTTTCTGCAAAGGGGCAGA
GTTAATTGTATTTGGAACCCATGACAGCACCTACTGGGGAAAGACTTCTAAGTGAGGAGAAACGGCTCTACAGGTCATGAAACTATGGAA
ATGAGATGGTTTTTGTCAAAGATTCAGGATGACTTCAGAGGTGGAAAAATTAACCTAGAAAAAACTCAGAGGTTACTTGAAAAATTAGAT
ATTCGGTGCAGTTATATTCATGTGAAACAGATTTTTAAGACATCTGACTACCCAGTGGTGCTCTCTTTAGAAAATCACTGCTCCACTGCC
CAACAAGAAGTAATGGCAGACAATTTGCAGGCTACTTTTGGAGAGTCCTTGCTTTCTGATATGCTTGATGATTTTCCTGATACTCTACCA
TCACCAGAGGCACTAAAATTCAAAATATTAGTTAAAAATAAGAAAATAGGAACCTTAAAGGAAACCCATGAAAGAAAAGGTTCTGATAAG
CGTGGAGACAATCAAGACAAGGAAACAGGGGTAAAAAAGTTACCTGGAGTAATGCTTTTCAAGAAAAAGAAGACCAGGAAGCTAAAAATT
GCTCTGGCCTTATCTGATCTTGTCATTTATACGAAAGCTGAGAAATTCAAAAGCTTTCAACATTCAAGATTATATCAGCAATTTAATGAA
AATAATTCTATTGGGGAGACACAAGCCCGAAAACTTTCAAAATTGCGAGTCCATGAGTTTATTTTTCACACCAGGAAGTTCATTACCAGA
ATATATCCCAAAGCAACAAGAGCAGACTCTTCTAATTTTAATCCCCAAGAATTTTGGAATATAGGTTGTCAAATGGTGGCTTTAAATTTC
CAGACCCCTGGTCTGCCCATGGATCTGCAAAATGGGAAATTTTTGGATAATGGTGGTTCTGGATATATTTTGAAACCACATTTCTTAAGA
GAGAGTAAATCATACTTTAACCCAAGTAACATAAAAGAGGGTATGCCAATTACACTTACAATAAGGGAGGCATTGAAATTTTCAGCAGAG
ACCTTCCAAGGACATATTGCAGGATTCTGTAATAGTGAACATATGGAAAGTATTAGAAATATTTATTGTCTGTAAATACTGTAAATGCAT
TGGAATAAAACTGTCTCCCCCATTGCTCTATGAAACTGCACATTGGTCATTGTGAATATTTTTTTTTTGCCAAGGCTAATCCAATTATTA
TTATCACATTTACCATAATTTATTTTGTCCATTGATGTATTTATTTTGTAAATGTATCTTGGTGCTGCTGAATTTCTATATTTTTTGTAA

>66077_66077_5_PLCZ1-PTHLH_PLCZ1_chr12_18847844_ENST00000435379_PTHLH_chr12_28111501_ENST00000539239_length(amino acids)=326AA_BP=294
MEMRWFLSKIQDDFRGGKINLEKTQRLLEKLDIRCSYIHVKQIFKTSDYPVVLSLENHCSTAQQEVMADNLQATFGESLLSDMLDDFPDT
LPSPEALKFKILVKNKKIGTLKETHERKGSDKRGDNQDKETGVKKLPGVMLFKKKKTRKLKIALALSDLVIYTKAEKFKSFQHSRLYQQF
NENNSIGETQARKLSKLRVHEFIFHTRKFITRIYPKATRADSSNFNPQEFWNIGCQMVALNFQTPGLPMDLQNGKFLDNGGSGYILKPHF

--------------------------------------------------------------
>66077_66077_6_PLCZ1-PTHLH_PLCZ1_chr12_18847844_ENST00000435379_PTHLH_chr12_28111501_ENST00000545234_length(transcript)=1295nt_BP=1146nt
ACAATGGGAATTCAGACCAAAAGGAAAAAATGACAGTCACCTGACAGTGTGGTGCCCAGCCAACCAGCTATACCTCTTTTGAAGATTTTA
AGAACTTAGCCTCCTGAACAGTCTTCTTCGAAAGTGAAAAGTGGTAACAGCTGATGAGTATCAAGAAATTATTTTCTGCAAAGGGGCAGA
GTTAATTGTATTTGGAACCCATGACAGCACCTACTGGGGAAAGACTTCTAAGTGAGGAGAAACGGCTCTACAGGTCATGAAACTATGGAA
ATGAGATGGTTTTTGTCAAAGATTCAGGATGACTTCAGAGGTGGAAAAATTAACCTAGAAAAAACTCAGAGGTTACTTGAAAAATTAGAT
ATTCGGTGCAGTTATATTCATGTGAAACAGATTTTTAAGACATCTGACTACCCAGTGGTGCTCTCTTTAGAAAATCACTGCTCCACTGCC
CAACAAGAAGTAATGGCAGACAATTTGCAGGCTACTTTTGGAGAGTCCTTGCTTTCTGATATGCTTGATGATTTTCCTGATACTCTACCA
TCACCAGAGGCACTAAAATTCAAAATATTAGTTAAAAATAAGAAAATAGGAACCTTAAAGGAAACCCATGAAAGAAAAGGTTCTGATAAG
CGTGGAGACAATCAAGACAAGGAAACAGGGGTAAAAAAGTTACCTGGAGTAATGCTTTTCAAGAAAAAGAAGACCAGGAAGCTAAAAATT
GCTCTGGCCTTATCTGATCTTGTCATTTATACGAAAGCTGAGAAATTCAAAAGCTTTCAACATTCAAGATTATATCAGCAATTTAATGAA
AATAATTCTATTGGGGAGACACAAGCCCGAAAACTTTCAAAATTGCGAGTCCATGAGTTTATTTTTCACACCAGGAAGTTCATTACCAGA
ATATATCCCAAAGCAACAAGAGCAGACTCTTCTAATTTTAATCCCCAAGAATTTTGGAATATAGGTTGTCAAATGGTGGCTTTAAATTTC
CAGACCCCTGGTCTGCCCATGGATCTGCAAAATGGGAAATTTTTGGATAATGGTGGTTCTGGATATATTTTGAAACCACATTTCTTAAGA
GAGAGTAAATCATACTTTAACCCAAGTAACATAAAAGAGGGTATGCCAATTACACTTACAATAAGGGAGGCATTGAAATTTTCAGCAGAG
ACCTTCCAAGGACATATTGCAGGATTCTGTAATAGTGAACATATGGAAAGTATTAGAAATATTTATTGTCTGTAAATACTGTAAATGCAT

>66077_66077_6_PLCZ1-PTHLH_PLCZ1_chr12_18847844_ENST00000435379_PTHLH_chr12_28111501_ENST00000545234_length(amino acids)=326AA_BP=294
MEMRWFLSKIQDDFRGGKINLEKTQRLLEKLDIRCSYIHVKQIFKTSDYPVVLSLENHCSTAQQEVMADNLQATFGESLLSDMLDDFPDT
LPSPEALKFKILVKNKKIGTLKETHERKGSDKRGDNQDKETGVKKLPGVMLFKKKKTRKLKIALALSDLVIYTKAEKFKSFQHSRLYQQF
NENNSIGETQARKLSKLRVHEFIFHTRKFITRIYPKATRADSSNFNPQEFWNIGCQMVALNFQTPGLPMDLQNGKFLDNGGSGYILKPHF

--------------------------------------------------------------
>66077_66077_7_PLCZ1-PTHLH_PLCZ1_chr12_18847844_ENST00000447925_PTHLH_chr12_28111501_ENST00000395872_length(transcript)=2210nt_BP=1725nt
ACAATGGGAATTCAGACCAAAAGGAAAAAATGACAGTCACCTGACAGTGTGGTGCCCAGCCAACCAGCTATACCTCTTTTGAAGATTTTA
AGAACTTAGCCTCCTGAACAGTCTTCTTCGAAAGTGAAAAGTGGTAACAGCTGATGAGTATCAAGAAATTATTTTCTGCAAAGGGGCAGA
GTTAATTGTATTTGGAACCCATGACAGCACCTACTGGGGAAAGACTTCTAAGTGAGGAGAAACGGCTCTACAGGTCATGAAACTATGGAA
ATGAGATGGTTTTTGTCAAAGATTCAGGATGACTTCAGAGGTGGAAAAATTAACCTAGAAAAAACTCAGAGGTTACTTGAAAAATTAGAT
ATTCGGTGCAGTTATATTCATGTGAAACAGATTTTTAAGGACAATGACAGGCTGAAACAAGGAAGAATCACCATAGAAGAATTTAGAGCA
ATTTATCGAATTATCACGCACAGAGAAGAAATTATTGAGATTTTCAACACATATTCTGAAAACCGGAAAATTCTTTTAGCAAGTAATCTG
GCTCAATTTCTGACACAAGAACAATATGCAGCTGAGATGAGTAAAGCTATTGCTTTTGAGATCATTCAGAAATACGAGCCTATCGAAGAA
GTTAGGAAAGCACACCAAATGTCATTAGAAGGTTTTACAAGATACATGGATTCACGTGAATGTCTACTGTTTAAAAATGAATGTAGAAAA
GTTTATCAAGATATGACTCATCCATTAAATGATTATTTTATTTCATCTTCACATAACACATATTTGGTATCTGATCAATTATTGGGACCA
AGTGACCTTTGGGGATATGTAAGTGCCCTTGTGAAAGGATGCCGTTGTTTGGAGATTGACTGCTGGGATGGAGCACAAAATGAACCTGTT
GTATATCATGGCTACACACTCACAAGCAAACTTCTGTTTAAAACTGTTATCCAAGCTATACACAAGTATGCATTCATGACATCTGACTAC
CCAGTGGTGCTCTCTTTAGAAAATCACTGCTCCACTGCCCAACAAGAAGTAATGGCAGACAATTTGCAGGCTACTTTTGGAGAGTCCTTG
CTTTCTGATATGCTTGATGATTTTCCTGATACTCTACCATCACCAGAGGCACTAAAATTCAAAATATTAGTTAAAAATAAGAAAATAGGA
ACCTTAAAGGAAACCCATGAAAGAAAAGGTTCTGATAAGCGTGGAGACAATCAAGACAAGGAAACAGGGGTAAAAAAGTTACCTGGAGTA
ATGCTTTTCAAGAAAAAGAAGACCAGGAAGCTAAAAATTGCTCTGGCCTTATCTGATCTTGTCATTTATACGAAAGCTGAGAAATTCAAA
AGCTTTCAACATTCAAGATTATATCAGCAATTTAATGAAAATAATTCTATTGGGGAGACACAAGCCCGAAAACTTTCAAAATTGCGAGTC
CATGAGTTTATTTTTCACACCAGGAAGTTCATTACCAGAATATATCCCAAAGCAACAAGAGCAGACTCTTCTAATTTTAATCCCCAAGAA
TTTTGGAATATAGGTTGTCAAATGGTGGCTTTAAATTTCCAGACCCCTGGTCTGCCCATGGATCTGCAAAATGGGAAATTTTTGGATAAT
GGTGGTTCTGGATATATTTTGAAACCACATTTCTTAAGAGAGAGTAAATCATACTTTAACCCAAGTAACATAAAAGAGGGTATGCCAATT
ACACTTACAATAAGGGAGGCATTGAAATTTTCAGCAGAGACCTTCCAAGGACATATTGCAGGATTCTGTAATAGTGAACATATGGAAAGT
ATTAGAAATATTTATTGTCTGTAAATACTGTAAATGCATTGGAATAAAACTGTCTCCCCCATTGCTCTATGAAACTGCACATTGGTCATT
GTGAATATTTTTTTTTTGCCAAGGCTAATCCAATTATTATTATCACATTTACCATAATTTATTTTGTCCATTGATGTATTTATTTTGTAA
ATGTATCTTGGTGCTGCTGAATTTCTATATTTTTTGTAACATAATGCACTTTAGATATACATATCAAGTATGTTGATAAATGACACAATG
AAGTGTCTCTATTTTGTGGTTGATTTTAATGAATGCCTAAATATAATTATCCAAATTGATTTTCCTTTGTGCATGTAAAAATAACAGTAT

>66077_66077_7_PLCZ1-PTHLH_PLCZ1_chr12_18847844_ENST00000447925_PTHLH_chr12_28111501_ENST00000395872_length(amino acids)=519AA_BP=487
MEMRWFLSKIQDDFRGGKINLEKTQRLLEKLDIRCSYIHVKQIFKDNDRLKQGRITIEEFRAIYRIITHREEIIEIFNTYSENRKILLAS
NLAQFLTQEQYAAEMSKAIAFEIIQKYEPIEEVRKAHQMSLEGFTRYMDSRECLLFKNECRKVYQDMTHPLNDYFISSSHNTYLVSDQLL
GPSDLWGYVSALVKGCRCLEIDCWDGAQNEPVVYHGYTLTSKLLFKTVIQAIHKYAFMTSDYPVVLSLENHCSTAQQEVMADNLQATFGE
SLLSDMLDDFPDTLPSPEALKFKILVKNKKIGTLKETHERKGSDKRGDNQDKETGVKKLPGVMLFKKKKTRKLKIALALSDLVIYTKAEK
FKSFQHSRLYQQFNENNSIGETQARKLSKLRVHEFIFHTRKFITRIYPKATRADSSNFNPQEFWNIGCQMVALNFQTPGLPMDLQNGKFL

--------------------------------------------------------------
>66077_66077_8_PLCZ1-PTHLH_PLCZ1_chr12_18847844_ENST00000447925_PTHLH_chr12_28111501_ENST00000539239_length(transcript)=2024nt_BP=1725nt
ACAATGGGAATTCAGACCAAAAGGAAAAAATGACAGTCACCTGACAGTGTGGTGCCCAGCCAACCAGCTATACCTCTTTTGAAGATTTTA
AGAACTTAGCCTCCTGAACAGTCTTCTTCGAAAGTGAAAAGTGGTAACAGCTGATGAGTATCAAGAAATTATTTTCTGCAAAGGGGCAGA
GTTAATTGTATTTGGAACCCATGACAGCACCTACTGGGGAAAGACTTCTAAGTGAGGAGAAACGGCTCTACAGGTCATGAAACTATGGAA
ATGAGATGGTTTTTGTCAAAGATTCAGGATGACTTCAGAGGTGGAAAAATTAACCTAGAAAAAACTCAGAGGTTACTTGAAAAATTAGAT
ATTCGGTGCAGTTATATTCATGTGAAACAGATTTTTAAGGACAATGACAGGCTGAAACAAGGAAGAATCACCATAGAAGAATTTAGAGCA
ATTTATCGAATTATCACGCACAGAGAAGAAATTATTGAGATTTTCAACACATATTCTGAAAACCGGAAAATTCTTTTAGCAAGTAATCTG
GCTCAATTTCTGACACAAGAACAATATGCAGCTGAGATGAGTAAAGCTATTGCTTTTGAGATCATTCAGAAATACGAGCCTATCGAAGAA
GTTAGGAAAGCACACCAAATGTCATTAGAAGGTTTTACAAGATACATGGATTCACGTGAATGTCTACTGTTTAAAAATGAATGTAGAAAA
GTTTATCAAGATATGACTCATCCATTAAATGATTATTTTATTTCATCTTCACATAACACATATTTGGTATCTGATCAATTATTGGGACCA
AGTGACCTTTGGGGATATGTAAGTGCCCTTGTGAAAGGATGCCGTTGTTTGGAGATTGACTGCTGGGATGGAGCACAAAATGAACCTGTT
GTATATCATGGCTACACACTCACAAGCAAACTTCTGTTTAAAACTGTTATCCAAGCTATACACAAGTATGCATTCATGACATCTGACTAC
CCAGTGGTGCTCTCTTTAGAAAATCACTGCTCCACTGCCCAACAAGAAGTAATGGCAGACAATTTGCAGGCTACTTTTGGAGAGTCCTTG
CTTTCTGATATGCTTGATGATTTTCCTGATACTCTACCATCACCAGAGGCACTAAAATTCAAAATATTAGTTAAAAATAAGAAAATAGGA
ACCTTAAAGGAAACCCATGAAAGAAAAGGTTCTGATAAGCGTGGAGACAATCAAGACAAGGAAACAGGGGTAAAAAAGTTACCTGGAGTA
ATGCTTTTCAAGAAAAAGAAGACCAGGAAGCTAAAAATTGCTCTGGCCTTATCTGATCTTGTCATTTATACGAAAGCTGAGAAATTCAAA
AGCTTTCAACATTCAAGATTATATCAGCAATTTAATGAAAATAATTCTATTGGGGAGACACAAGCCCGAAAACTTTCAAAATTGCGAGTC
CATGAGTTTATTTTTCACACCAGGAAGTTCATTACCAGAATATATCCCAAAGCAACAAGAGCAGACTCTTCTAATTTTAATCCCCAAGAA
TTTTGGAATATAGGTTGTCAAATGGTGGCTTTAAATTTCCAGACCCCTGGTCTGCCCATGGATCTGCAAAATGGGAAATTTTTGGATAAT
GGTGGTTCTGGATATATTTTGAAACCACATTTCTTAAGAGAGAGTAAATCATACTTTAACCCAAGTAACATAAAAGAGGGTATGCCAATT
ACACTTACAATAAGGGAGGCATTGAAATTTTCAGCAGAGACCTTCCAAGGACATATTGCAGGATTCTGTAATAGTGAACATATGGAAAGT
ATTAGAAATATTTATTGTCTGTAAATACTGTAAATGCATTGGAATAAAACTGTCTCCCCCATTGCTCTATGAAACTGCACATTGGTCATT
GTGAATATTTTTTTTTTGCCAAGGCTAATCCAATTATTATTATCACATTTACCATAATTTATTTTGTCCATTGATGTATTTATTTTGTAA

>66077_66077_8_PLCZ1-PTHLH_PLCZ1_chr12_18847844_ENST00000447925_PTHLH_chr12_28111501_ENST00000539239_length(amino acids)=519AA_BP=487
MEMRWFLSKIQDDFRGGKINLEKTQRLLEKLDIRCSYIHVKQIFKDNDRLKQGRITIEEFRAIYRIITHREEIIEIFNTYSENRKILLAS
NLAQFLTQEQYAAEMSKAIAFEIIQKYEPIEEVRKAHQMSLEGFTRYMDSRECLLFKNECRKVYQDMTHPLNDYFISSSHNTYLVSDQLL
GPSDLWGYVSALVKGCRCLEIDCWDGAQNEPVVYHGYTLTSKLLFKTVIQAIHKYAFMTSDYPVVLSLENHCSTAQQEVMADNLQATFGE
SLLSDMLDDFPDTLPSPEALKFKILVKNKKIGTLKETHERKGSDKRGDNQDKETGVKKLPGVMLFKKKKTRKLKIALALSDLVIYTKAEK
FKSFQHSRLYQQFNENNSIGETQARKLSKLRVHEFIFHTRKFITRIYPKATRADSSNFNPQEFWNIGCQMVALNFQTPGLPMDLQNGKFL

--------------------------------------------------------------
>66077_66077_9_PLCZ1-PTHLH_PLCZ1_chr12_18847844_ENST00000447925_PTHLH_chr12_28111501_ENST00000545234_length(transcript)=1874nt_BP=1725nt
ACAATGGGAATTCAGACCAAAAGGAAAAAATGACAGTCACCTGACAGTGTGGTGCCCAGCCAACCAGCTATACCTCTTTTGAAGATTTTA
AGAACTTAGCCTCCTGAACAGTCTTCTTCGAAAGTGAAAAGTGGTAACAGCTGATGAGTATCAAGAAATTATTTTCTGCAAAGGGGCAGA
GTTAATTGTATTTGGAACCCATGACAGCACCTACTGGGGAAAGACTTCTAAGTGAGGAGAAACGGCTCTACAGGTCATGAAACTATGGAA
ATGAGATGGTTTTTGTCAAAGATTCAGGATGACTTCAGAGGTGGAAAAATTAACCTAGAAAAAACTCAGAGGTTACTTGAAAAATTAGAT
ATTCGGTGCAGTTATATTCATGTGAAACAGATTTTTAAGGACAATGACAGGCTGAAACAAGGAAGAATCACCATAGAAGAATTTAGAGCA
ATTTATCGAATTATCACGCACAGAGAAGAAATTATTGAGATTTTCAACACATATTCTGAAAACCGGAAAATTCTTTTAGCAAGTAATCTG
GCTCAATTTCTGACACAAGAACAATATGCAGCTGAGATGAGTAAAGCTATTGCTTTTGAGATCATTCAGAAATACGAGCCTATCGAAGAA
GTTAGGAAAGCACACCAAATGTCATTAGAAGGTTTTACAAGATACATGGATTCACGTGAATGTCTACTGTTTAAAAATGAATGTAGAAAA
GTTTATCAAGATATGACTCATCCATTAAATGATTATTTTATTTCATCTTCACATAACACATATTTGGTATCTGATCAATTATTGGGACCA
AGTGACCTTTGGGGATATGTAAGTGCCCTTGTGAAAGGATGCCGTTGTTTGGAGATTGACTGCTGGGATGGAGCACAAAATGAACCTGTT
GTATATCATGGCTACACACTCACAAGCAAACTTCTGTTTAAAACTGTTATCCAAGCTATACACAAGTATGCATTCATGACATCTGACTAC
CCAGTGGTGCTCTCTTTAGAAAATCACTGCTCCACTGCCCAACAAGAAGTAATGGCAGACAATTTGCAGGCTACTTTTGGAGAGTCCTTG
CTTTCTGATATGCTTGATGATTTTCCTGATACTCTACCATCACCAGAGGCACTAAAATTCAAAATATTAGTTAAAAATAAGAAAATAGGA
ACCTTAAAGGAAACCCATGAAAGAAAAGGTTCTGATAAGCGTGGAGACAATCAAGACAAGGAAACAGGGGTAAAAAAGTTACCTGGAGTA
ATGCTTTTCAAGAAAAAGAAGACCAGGAAGCTAAAAATTGCTCTGGCCTTATCTGATCTTGTCATTTATACGAAAGCTGAGAAATTCAAA
AGCTTTCAACATTCAAGATTATATCAGCAATTTAATGAAAATAATTCTATTGGGGAGACACAAGCCCGAAAACTTTCAAAATTGCGAGTC
CATGAGTTTATTTTTCACACCAGGAAGTTCATTACCAGAATATATCCCAAAGCAACAAGAGCAGACTCTTCTAATTTTAATCCCCAAGAA
TTTTGGAATATAGGTTGTCAAATGGTGGCTTTAAATTTCCAGACCCCTGGTCTGCCCATGGATCTGCAAAATGGGAAATTTTTGGATAAT
GGTGGTTCTGGATATATTTTGAAACCACATTTCTTAAGAGAGAGTAAATCATACTTTAACCCAAGTAACATAAAAGAGGGTATGCCAATT
ACACTTACAATAAGGGAGGCATTGAAATTTTCAGCAGAGACCTTCCAAGGACATATTGCAGGATTCTGTAATAGTGAACATATGGAAAGT

>66077_66077_9_PLCZ1-PTHLH_PLCZ1_chr12_18847844_ENST00000447925_PTHLH_chr12_28111501_ENST00000545234_length(amino acids)=519AA_BP=487
MEMRWFLSKIQDDFRGGKINLEKTQRLLEKLDIRCSYIHVKQIFKDNDRLKQGRITIEEFRAIYRIITHREEIIEIFNTYSENRKILLAS
NLAQFLTQEQYAAEMSKAIAFEIIQKYEPIEEVRKAHQMSLEGFTRYMDSRECLLFKNECRKVYQDMTHPLNDYFISSSHNTYLVSDQLL
GPSDLWGYVSALVKGCRCLEIDCWDGAQNEPVVYHGYTLTSKLLFKTVIQAIHKYAFMTSDYPVVLSLENHCSTAQQEVMADNLQATFGE
SLLSDMLDDFPDTLPSPEALKFKILVKNKKIGTLKETHERKGSDKRGDNQDKETGVKKLPGVMLFKKKKTRKLKIALALSDLVIYTKAEK
FKSFQHSRLYQQFNENNSIGETQARKLSKLRVHEFIFHTRKFITRIYPKATRADSSNFNPQEFWNIGCQMVALNFQTPGLPMDLQNGKFL

--------------------------------------------------------------
>66077_66077_10_PLCZ1-PTHLH_PLCZ1_chr12_18847844_ENST00000538330_PTHLH_chr12_28111501_ENST00000395872_length(transcript)=1674nt_BP=1189nt
TTACAAACCTCTCCCTATCTCCAGTTGTGGCAGCCGAAAATGTCTCCAGACATTGCCAAATCCCTCCTGTGAGGCAAAGTCGTCCCAGTG
GAAAACCAGTAGCCTGTAGACATGGGGTAGAAAAATCAGGCCCAGTTTTAGATATCAGCAGAAGCAGAAATATAGTTTCCTCAGTTTTGA
TAAAGCTGTGAACTTGTATTCTGAGTGCCCTTGTGAAAGGATGCCGTTGTTTGGAGATTGACTGCTGGGATGGAGCACAAAATGAACCTG
TTGTATATCATGGCTACACACTCACAAGCAAACTTCTGTTTAAAACTGTTATCCAAGCTATACACAAGTATGCATTCATGAAAATCACTG
CTCCACTGCCCAACAAGAAGTAATGGCAGACAATTTGCAGGCTACTTTTGGAGAGTCCTTGCTTTCTGATATGCTTGATGATTTTCCTGA
TACTCTACCATCACCAGAGGCACTAAAATTCAAAATATTAGTTAAAAATAAGAAAATAGGAACCTTAAAGGAAACCCATGAAAGAAAAGG
TTCTGATAAGCGTGGTAAGGTGGAGGAATGGGAAGAAGAAGTGGCAGATGGAGAGGAGGAGGAGGAGGAGGAGGAGGAGGAGGAGGAGGA
GGAGGAGGATAAATTCAAAGAATCAGAAGTATTGGAATCTGTTTTAGGAGACAATCAAGACAAGGAAACAGGGGTAAAAAAGTTACCTGG
AGTAATGCTTTTCAAGAAAAAGAAGACCAGGAAGCTAAAAATTGCTCTGGCCTTATCTGATCTTGTCATTTATACGAAAGCTGAGAAATT
CAAAAGCTTTCAACATTCAAGATTATATCAGCAATTTAATGAAAATAATTCTATTGGGGAGACACAAGCCCGAAAACTTTCAAAATTGCG
AGTCCATGAGTTTATTTTTCACACCAGGAAGTTCATTACCAGAATATATCCCAAAGCAACAAGAGCAGACTCTTCTAATTTTAATCCCCA
AGAATTTTGGAATATAGGTTGTCAAATGGTGGCTTTAAATTTCCAGACCCCTGGTCTGCCCATGGATCTGCAAAATGGGAAATTTTTGGA
TAATGGTGGTTCTGGATATATTTTGAAACCACATTTCTTAAGAGAGAGTAAATCATACTTTAACCCAAGTAACATAAAAGAGGGTATGCC
AATTACACTTACAATAAGGGAGGCATTGAAATTTTCAGCAGAGACCTTCCAAGGACATATTGCAGGATTCTGTAATAGTGAACATATGGA
AAGTATTAGAAATATTTATTGTCTGTAAATACTGTAAATGCATTGGAATAAAACTGTCTCCCCCATTGCTCTATGAAACTGCACATTGGT
CATTGTGAATATTTTTTTTTTGCCAAGGCTAATCCAATTATTATTATCACATTTACCATAATTTATTTTGTCCATTGATGTATTTATTTT
GTAAATGTATCTTGGTGCTGCTGAATTTCTATATTTTTTGTAACATAATGCACTTTAGATATACATATCAAGTATGTTGATAAATGACAC
AATGAAGTGTCTCTATTTTGTGGTTGATTTTAATGAATGCCTAAATATAATTATCCAAATTGATTTTCCTTTGTGCATGTAAAAATAACA

>66077_66077_10_PLCZ1-PTHLH_PLCZ1_chr12_18847844_ENST00000538330_PTHLH_chr12_28111501_ENST00000395872_length(amino acids)=301AA_BP=269
MADNLQATFGESLLSDMLDDFPDTLPSPEALKFKILVKNKKIGTLKETHERKGSDKRGKVEEWEEEVADGEEEEEEEEEEEEEEEDKFKE
SEVLESVLGDNQDKETGVKKLPGVMLFKKKKTRKLKIALALSDLVIYTKAEKFKSFQHSRLYQQFNENNSIGETQARKLSKLRVHEFIFH
TRKFITRIYPKATRADSSNFNPQEFWNIGCQMVALNFQTPGLPMDLQNGKFLDNGGSGYILKPHFLRESKSYFNPSNIKEGMPITLTIRE

--------------------------------------------------------------
>66077_66077_11_PLCZ1-PTHLH_PLCZ1_chr12_18847844_ENST00000538330_PTHLH_chr12_28111501_ENST00000539239_length(transcript)=1488nt_BP=1189nt
TTACAAACCTCTCCCTATCTCCAGTTGTGGCAGCCGAAAATGTCTCCAGACATTGCCAAATCCCTCCTGTGAGGCAAAGTCGTCCCAGTG
GAAAACCAGTAGCCTGTAGACATGGGGTAGAAAAATCAGGCCCAGTTTTAGATATCAGCAGAAGCAGAAATATAGTTTCCTCAGTTTTGA
TAAAGCTGTGAACTTGTATTCTGAGTGCCCTTGTGAAAGGATGCCGTTGTTTGGAGATTGACTGCTGGGATGGAGCACAAAATGAACCTG
TTGTATATCATGGCTACACACTCACAAGCAAACTTCTGTTTAAAACTGTTATCCAAGCTATACACAAGTATGCATTCATGAAAATCACTG
CTCCACTGCCCAACAAGAAGTAATGGCAGACAATTTGCAGGCTACTTTTGGAGAGTCCTTGCTTTCTGATATGCTTGATGATTTTCCTGA
TACTCTACCATCACCAGAGGCACTAAAATTCAAAATATTAGTTAAAAATAAGAAAATAGGAACCTTAAAGGAAACCCATGAAAGAAAAGG
TTCTGATAAGCGTGGTAAGGTGGAGGAATGGGAAGAAGAAGTGGCAGATGGAGAGGAGGAGGAGGAGGAGGAGGAGGAGGAGGAGGAGGA
GGAGGAGGATAAATTCAAAGAATCAGAAGTATTGGAATCTGTTTTAGGAGACAATCAAGACAAGGAAACAGGGGTAAAAAAGTTACCTGG
AGTAATGCTTTTCAAGAAAAAGAAGACCAGGAAGCTAAAAATTGCTCTGGCCTTATCTGATCTTGTCATTTATACGAAAGCTGAGAAATT
CAAAAGCTTTCAACATTCAAGATTATATCAGCAATTTAATGAAAATAATTCTATTGGGGAGACACAAGCCCGAAAACTTTCAAAATTGCG
AGTCCATGAGTTTATTTTTCACACCAGGAAGTTCATTACCAGAATATATCCCAAAGCAACAAGAGCAGACTCTTCTAATTTTAATCCCCA
AGAATTTTGGAATATAGGTTGTCAAATGGTGGCTTTAAATTTCCAGACCCCTGGTCTGCCCATGGATCTGCAAAATGGGAAATTTTTGGA
TAATGGTGGTTCTGGATATATTTTGAAACCACATTTCTTAAGAGAGAGTAAATCATACTTTAACCCAAGTAACATAAAAGAGGGTATGCC
AATTACACTTACAATAAGGGAGGCATTGAAATTTTCAGCAGAGACCTTCCAAGGACATATTGCAGGATTCTGTAATAGTGAACATATGGA
AAGTATTAGAAATATTTATTGTCTGTAAATACTGTAAATGCATTGGAATAAAACTGTCTCCCCCATTGCTCTATGAAACTGCACATTGGT
CATTGTGAATATTTTTTTTTTGCCAAGGCTAATCCAATTATTATTATCACATTTACCATAATTTATTTTGTCCATTGATGTATTTATTTT

>66077_66077_11_PLCZ1-PTHLH_PLCZ1_chr12_18847844_ENST00000538330_PTHLH_chr12_28111501_ENST00000539239_length(amino acids)=301AA_BP=269
MADNLQATFGESLLSDMLDDFPDTLPSPEALKFKILVKNKKIGTLKETHERKGSDKRGKVEEWEEEVADGEEEEEEEEEEEEEEEDKFKE
SEVLESVLGDNQDKETGVKKLPGVMLFKKKKTRKLKIALALSDLVIYTKAEKFKSFQHSRLYQQFNENNSIGETQARKLSKLRVHEFIFH
TRKFITRIYPKATRADSSNFNPQEFWNIGCQMVALNFQTPGLPMDLQNGKFLDNGGSGYILKPHFLRESKSYFNPSNIKEGMPITLTIRE

--------------------------------------------------------------
>66077_66077_12_PLCZ1-PTHLH_PLCZ1_chr12_18847844_ENST00000538330_PTHLH_chr12_28111501_ENST00000545234_length(transcript)=1338nt_BP=1189nt
TTACAAACCTCTCCCTATCTCCAGTTGTGGCAGCCGAAAATGTCTCCAGACATTGCCAAATCCCTCCTGTGAGGCAAAGTCGTCCCAGTG
GAAAACCAGTAGCCTGTAGACATGGGGTAGAAAAATCAGGCCCAGTTTTAGATATCAGCAGAAGCAGAAATATAGTTTCCTCAGTTTTGA
TAAAGCTGTGAACTTGTATTCTGAGTGCCCTTGTGAAAGGATGCCGTTGTTTGGAGATTGACTGCTGGGATGGAGCACAAAATGAACCTG
TTGTATATCATGGCTACACACTCACAAGCAAACTTCTGTTTAAAACTGTTATCCAAGCTATACACAAGTATGCATTCATGAAAATCACTG
CTCCACTGCCCAACAAGAAGTAATGGCAGACAATTTGCAGGCTACTTTTGGAGAGTCCTTGCTTTCTGATATGCTTGATGATTTTCCTGA
TACTCTACCATCACCAGAGGCACTAAAATTCAAAATATTAGTTAAAAATAAGAAAATAGGAACCTTAAAGGAAACCCATGAAAGAAAAGG
TTCTGATAAGCGTGGTAAGGTGGAGGAATGGGAAGAAGAAGTGGCAGATGGAGAGGAGGAGGAGGAGGAGGAGGAGGAGGAGGAGGAGGA
GGAGGAGGATAAATTCAAAGAATCAGAAGTATTGGAATCTGTTTTAGGAGACAATCAAGACAAGGAAACAGGGGTAAAAAAGTTACCTGG
AGTAATGCTTTTCAAGAAAAAGAAGACCAGGAAGCTAAAAATTGCTCTGGCCTTATCTGATCTTGTCATTTATACGAAAGCTGAGAAATT
CAAAAGCTTTCAACATTCAAGATTATATCAGCAATTTAATGAAAATAATTCTATTGGGGAGACACAAGCCCGAAAACTTTCAAAATTGCG
AGTCCATGAGTTTATTTTTCACACCAGGAAGTTCATTACCAGAATATATCCCAAAGCAACAAGAGCAGACTCTTCTAATTTTAATCCCCA
AGAATTTTGGAATATAGGTTGTCAAATGGTGGCTTTAAATTTCCAGACCCCTGGTCTGCCCATGGATCTGCAAAATGGGAAATTTTTGGA
TAATGGTGGTTCTGGATATATTTTGAAACCACATTTCTTAAGAGAGAGTAAATCATACTTTAACCCAAGTAACATAAAAGAGGGTATGCC
AATTACACTTACAATAAGGGAGGCATTGAAATTTTCAGCAGAGACCTTCCAAGGACATATTGCAGGATTCTGTAATAGTGAACATATGGA

>66077_66077_12_PLCZ1-PTHLH_PLCZ1_chr12_18847844_ENST00000538330_PTHLH_chr12_28111501_ENST00000545234_length(amino acids)=301AA_BP=269
MADNLQATFGESLLSDMLDDFPDTLPSPEALKFKILVKNKKIGTLKETHERKGSDKRGKVEEWEEEVADGEEEEEEEEEEEEEEEDKFKE
SEVLESVLGDNQDKETGVKKLPGVMLFKKKKTRKLKIALALSDLVIYTKAEKFKSFQHSRLYQQFNENNSIGETQARKLSKLRVHEFIFH
TRKFITRIYPKATRADSSNFNPQEFWNIGCQMVALNFQTPGLPMDLQNGKFLDNGGSGYILKPHFLRESKSYFNPSNIKEGMPITLTIRE

--------------------------------------------------------------
>66077_66077_13_PLCZ1-PTHLH_PLCZ1_chr12_18847844_ENST00000541695_PTHLH_chr12_28111501_ENST00000395872_length(transcript)=1560nt_BP=1075nt
GTCATTAGAAGGTTTTACAAGATACATGGATTCACGTGAATGTCTACTGTTTAAAAATGAATGTAGAAAAGTTTATCAAGATATGACTCA
TCCATTAAATGATTATTTTATTTCATCTTCACATAACACATATTTGGTATCTGATCAATTATTGGGACCAAGTGACCTTTGGGGATATGT
AAGTGCCCTTGTGAAAGGATGCCGTTGTTTGGAGATTGACTGCTGGGATGGAGCACAAAATGAACCTGTTGTATATCATGGCTACACACT
CACAAGCAAACTTCTGTTTAAAACTGTTATCCAAGCTATACACAAGTATGCATTCATGACATCTGACTACCCAGTGGTGCTCTCTTTAGA
AAATCACTGCTCCACTGCCCAACAAGAAGTAATGGCAGACAATTTGCAGGCTACTTTTGGAGAGTCCTTGCTTTCTGATATGCTTGATGA
TTTTCCTGATACTCTACCATCACCAGAGGCACTAAAATTCAAAATATTAGTTAAAAATAAGAAAATAGGAACCTTAAAGGAAACCCATGA
AAGAAAAGGTTCTGATAAGCGTGGAGACAATCAAGACAAGGAAACAGGGGTAAAAAAGTTACCTGGAGTAATGCTTTTCAAGAAAAAGAA
GACCAGGAAGCTAAAAATTGCTCTGGCCTTATCTGATCTTGTCATTTATACGAAAGCTGAGAAATTCAAAAGCTTTCAACATTCAAGATT
ATATCAGCAATTTAATGAAAATAATTCTATTGGGGAGACACAAGCCCGAAAACTTTCAAAATTGCGAGTCCATGAGTTTATTTTTCACAC
CAGGAAGTTCATTACCAGAATATATCCCAAAGCAACAAGAGCAGACTCTTCTAATTTTAATCCCCAAGAATTTTGGAATATAGGTTGTCA
AATGGTGGCTTTAAATTTCCAGACCCCTGGTCTGCCCATGGATCTGCAAAATGGGAAATTTTTGGATAATGGTGGTTCTGGATATATTTT
GAAACCACATTTCTTAAGAGAGAGTAAATCATACTTTAACCCAAGTAACATAAAAGAGGGTATGCCAATTACACTTACAATAAGGGAGGC
ATTGAAATTTTCAGCAGAGACCTTCCAAGGACATATTGCAGGATTCTGTAATAGTGAACATATGGAAAGTATTAGAAATATTTATTGTCT
GTAAATACTGTAAATGCATTGGAATAAAACTGTCTCCCCCATTGCTCTATGAAACTGCACATTGGTCATTGTGAATATTTTTTTTTTGCC
AAGGCTAATCCAATTATTATTATCACATTTACCATAATTTATTTTGTCCATTGATGTATTTATTTTGTAAATGTATCTTGGTGCTGCTGA
ATTTCTATATTTTTTGTAACATAATGCACTTTAGATATACATATCAAGTATGTTGATAAATGACACAATGAAGTGTCTCTATTTTGTGGT
TGATTTTAATGAATGCCTAAATATAATTATCCAAATTGATTTTCCTTTGTGCATGTAAAAATAACAGTATTTTAAATTTGTAAAGAATGT

>66077_66077_13_PLCZ1-PTHLH_PLCZ1_chr12_18847844_ENST00000541695_PTHLH_chr12_28111501_ENST00000395872_length(amino acids)=382AA_BP=350
MDSRECLLFKNECRKVYQDMTHPLNDYFISSSHNTYLVSDQLLGPSDLWGYVSALVKGCRCLEIDCWDGAQNEPVVYHGYTLTSKLLFKT
VIQAIHKYAFMTSDYPVVLSLENHCSTAQQEVMADNLQATFGESLLSDMLDDFPDTLPSPEALKFKILVKNKKIGTLKETHERKGSDKRG
DNQDKETGVKKLPGVMLFKKKKTRKLKIALALSDLVIYTKAEKFKSFQHSRLYQQFNENNSIGETQARKLSKLRVHEFIFHTRKFITRIY
PKATRADSSNFNPQEFWNIGCQMVALNFQTPGLPMDLQNGKFLDNGGSGYILKPHFLRESKSYFNPSNIKEGMPITLTIREALKFSAETF

--------------------------------------------------------------
>66077_66077_14_PLCZ1-PTHLH_PLCZ1_chr12_18847844_ENST00000541695_PTHLH_chr12_28111501_ENST00000539239_length(transcript)=1374nt_BP=1075nt
GTCATTAGAAGGTTTTACAAGATACATGGATTCACGTGAATGTCTACTGTTTAAAAATGAATGTAGAAAAGTTTATCAAGATATGACTCA
TCCATTAAATGATTATTTTATTTCATCTTCACATAACACATATTTGGTATCTGATCAATTATTGGGACCAAGTGACCTTTGGGGATATGT
AAGTGCCCTTGTGAAAGGATGCCGTTGTTTGGAGATTGACTGCTGGGATGGAGCACAAAATGAACCTGTTGTATATCATGGCTACACACT
CACAAGCAAACTTCTGTTTAAAACTGTTATCCAAGCTATACACAAGTATGCATTCATGACATCTGACTACCCAGTGGTGCTCTCTTTAGA
AAATCACTGCTCCACTGCCCAACAAGAAGTAATGGCAGACAATTTGCAGGCTACTTTTGGAGAGTCCTTGCTTTCTGATATGCTTGATGA
TTTTCCTGATACTCTACCATCACCAGAGGCACTAAAATTCAAAATATTAGTTAAAAATAAGAAAATAGGAACCTTAAAGGAAACCCATGA
AAGAAAAGGTTCTGATAAGCGTGGAGACAATCAAGACAAGGAAACAGGGGTAAAAAAGTTACCTGGAGTAATGCTTTTCAAGAAAAAGAA
GACCAGGAAGCTAAAAATTGCTCTGGCCTTATCTGATCTTGTCATTTATACGAAAGCTGAGAAATTCAAAAGCTTTCAACATTCAAGATT
ATATCAGCAATTTAATGAAAATAATTCTATTGGGGAGACACAAGCCCGAAAACTTTCAAAATTGCGAGTCCATGAGTTTATTTTTCACAC
CAGGAAGTTCATTACCAGAATATATCCCAAAGCAACAAGAGCAGACTCTTCTAATTTTAATCCCCAAGAATTTTGGAATATAGGTTGTCA
AATGGTGGCTTTAAATTTCCAGACCCCTGGTCTGCCCATGGATCTGCAAAATGGGAAATTTTTGGATAATGGTGGTTCTGGATATATTTT
GAAACCACATTTCTTAAGAGAGAGTAAATCATACTTTAACCCAAGTAACATAAAAGAGGGTATGCCAATTACACTTACAATAAGGGAGGC
ATTGAAATTTTCAGCAGAGACCTTCCAAGGACATATTGCAGGATTCTGTAATAGTGAACATATGGAAAGTATTAGAAATATTTATTGTCT
GTAAATACTGTAAATGCATTGGAATAAAACTGTCTCCCCCATTGCTCTATGAAACTGCACATTGGTCATTGTGAATATTTTTTTTTTGCC
AAGGCTAATCCAATTATTATTATCACATTTACCATAATTTATTTTGTCCATTGATGTATTTATTTTGTAAATGTATCTTGGTGCTGCTGA

>66077_66077_14_PLCZ1-PTHLH_PLCZ1_chr12_18847844_ENST00000541695_PTHLH_chr12_28111501_ENST00000539239_length(amino acids)=382AA_BP=350
MDSRECLLFKNECRKVYQDMTHPLNDYFISSSHNTYLVSDQLLGPSDLWGYVSALVKGCRCLEIDCWDGAQNEPVVYHGYTLTSKLLFKT
VIQAIHKYAFMTSDYPVVLSLENHCSTAQQEVMADNLQATFGESLLSDMLDDFPDTLPSPEALKFKILVKNKKIGTLKETHERKGSDKRG
DNQDKETGVKKLPGVMLFKKKKTRKLKIALALSDLVIYTKAEKFKSFQHSRLYQQFNENNSIGETQARKLSKLRVHEFIFHTRKFITRIY
PKATRADSSNFNPQEFWNIGCQMVALNFQTPGLPMDLQNGKFLDNGGSGYILKPHFLRESKSYFNPSNIKEGMPITLTIREALKFSAETF

--------------------------------------------------------------
>66077_66077_15_PLCZ1-PTHLH_PLCZ1_chr12_18847844_ENST00000541695_PTHLH_chr12_28111501_ENST00000545234_length(transcript)=1224nt_BP=1075nt
GTCATTAGAAGGTTTTACAAGATACATGGATTCACGTGAATGTCTACTGTTTAAAAATGAATGTAGAAAAGTTTATCAAGATATGACTCA
TCCATTAAATGATTATTTTATTTCATCTTCACATAACACATATTTGGTATCTGATCAATTATTGGGACCAAGTGACCTTTGGGGATATGT
AAGTGCCCTTGTGAAAGGATGCCGTTGTTTGGAGATTGACTGCTGGGATGGAGCACAAAATGAACCTGTTGTATATCATGGCTACACACT
CACAAGCAAACTTCTGTTTAAAACTGTTATCCAAGCTATACACAAGTATGCATTCATGACATCTGACTACCCAGTGGTGCTCTCTTTAGA
AAATCACTGCTCCACTGCCCAACAAGAAGTAATGGCAGACAATTTGCAGGCTACTTTTGGAGAGTCCTTGCTTTCTGATATGCTTGATGA
TTTTCCTGATACTCTACCATCACCAGAGGCACTAAAATTCAAAATATTAGTTAAAAATAAGAAAATAGGAACCTTAAAGGAAACCCATGA
AAGAAAAGGTTCTGATAAGCGTGGAGACAATCAAGACAAGGAAACAGGGGTAAAAAAGTTACCTGGAGTAATGCTTTTCAAGAAAAAGAA
GACCAGGAAGCTAAAAATTGCTCTGGCCTTATCTGATCTTGTCATTTATACGAAAGCTGAGAAATTCAAAAGCTTTCAACATTCAAGATT
ATATCAGCAATTTAATGAAAATAATTCTATTGGGGAGACACAAGCCCGAAAACTTTCAAAATTGCGAGTCCATGAGTTTATTTTTCACAC
CAGGAAGTTCATTACCAGAATATATCCCAAAGCAACAAGAGCAGACTCTTCTAATTTTAATCCCCAAGAATTTTGGAATATAGGTTGTCA
AATGGTGGCTTTAAATTTCCAGACCCCTGGTCTGCCCATGGATCTGCAAAATGGGAAATTTTTGGATAATGGTGGTTCTGGATATATTTT
GAAACCACATTTCTTAAGAGAGAGTAAATCATACTTTAACCCAAGTAACATAAAAGAGGGTATGCCAATTACACTTACAATAAGGGAGGC
ATTGAAATTTTCAGCAGAGACCTTCCAAGGACATATTGCAGGATTCTGTAATAGTGAACATATGGAAAGTATTAGAAATATTTATTGTCT

>66077_66077_15_PLCZ1-PTHLH_PLCZ1_chr12_18847844_ENST00000541695_PTHLH_chr12_28111501_ENST00000545234_length(amino acids)=382AA_BP=350
MDSRECLLFKNECRKVYQDMTHPLNDYFISSSHNTYLVSDQLLGPSDLWGYVSALVKGCRCLEIDCWDGAQNEPVVYHGYTLTSKLLFKT
VIQAIHKYAFMTSDYPVVLSLENHCSTAQQEVMADNLQATFGESLLSDMLDDFPDTLPSPEALKFKILVKNKKIGTLKETHERKGSDKRG
DNQDKETGVKKLPGVMLFKKKKTRKLKIALALSDLVIYTKAEKFKSFQHSRLYQQFNENNSIGETQARKLSKLRVHEFIFHTRKFITRIY
PKATRADSSNFNPQEFWNIGCQMVALNFQTPGLPMDLQNGKFLDNGGSGYILKPHFLRESKSYFNPSNIKEGMPITLTIREALKFSAETF

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for PLCZ1-PTHLH


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for PLCZ1-PTHLH


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for PLCZ1-PTHLH


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource