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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARL5A-IL1B (FusionGDB2 ID:6610)

Fusion Gene Summary for ARL5A-IL1B

check button Fusion gene summary
Fusion gene informationFusion gene name: ARL5A-IL1B
Fusion gene ID: 6610
HgeneTgene
Gene symbol

ARL5A

IL1B

Gene ID

26225

3553

Gene nameADP ribosylation factor like GTPase 5Ainterleukin 1 beta
SynonymsARFLP5|ARL5IL-1|IL1-BETA|IL1F2|IL1beta
Cytomap

2q23.3

2q14.1

Type of geneprotein-codingprotein-coding
DescriptionADP-ribosylation factor-like protein 5AADP-ribosylation factor-like 5ADP-ribosylation factor-like 5AADP-ribosylation factor-like protein 5interleukin-1 betaIL-1 betacatabolininterleukin 1betapreinterleukin 1 betapro-interleukin-1-beta
Modification date2020031320200329
UniProtAcc

Q9Y689

P01584

Ensembl transtripts involved in fusion geneENST00000295087, ENST00000428992, 
ENST00000487723, 		ENST00000263341, 
ENST00000491056, 
Fusion gene scores* DoF score4 X 6 X 4=964 X 6 X 3=72
# samples 56
** MAII scorelog2(5/96*10)=-0.941106310946431
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARL5A [Title/Abstract] AND IL1B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARL5A(152668871)-IL1B(113593821), # samples:2
Anticipated loss of major functional domain due to fusion event.ARL5A-IL1B seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneIL1B

GO:0000187

activation of MAPK activity

10748004

TgeneIL1B

GO:0001934

positive regulation of protein phosphorylation

10748004

TgeneIL1B

GO:0006954

inflammatory response

10748004|21147091

TgeneIL1B

GO:0008284

positive regulation of cell proliferation

25204733

TgeneIL1B

GO:0008285

negative regulation of cell proliferation

3493774

TgeneIL1B

GO:0010575

positive regulation of vascular endothelial growth factor production

12958148

TgeneIL1B

GO:0010628

positive regulation of gene expression

11090614|21559518|23817958|25327529|26687115|29384235

TgeneIL1B

GO:0010718

positive regulation of epithelial to mesenchymal transition

25204733

TgeneIL1B

GO:0019221

cytokine-mediated signaling pathway

10748004

TgeneIL1B

GO:0030213

hyaluronan biosynthetic process

15100360

TgeneIL1B

GO:0030335

positive regulation of cell migration

25204733

TgeneIL1B

GO:0030730

sequestering of triglyceride

19032770

TgeneIL1B

GO:0031663

lipopolysaccharide-mediated signaling pathway

21147091

TgeneIL1B

GO:0032496

response to lipopolysaccharide

19193853

TgeneIL1B

GO:0032725

positive regulation of granulocyte macrophage colony-stimulating factor production

20027291

TgeneIL1B

GO:0032729

positive regulation of interferon-gamma production

10653850|20027291

TgeneIL1B

GO:0032757

positive regulation of interleukin-8 production

19524870

TgeneIL1B

GO:0034116

positive regulation of heterotypic cell-cell adhesion

15100360

TgeneIL1B

GO:0035505

positive regulation of myosin light chain kinase activity

18390750

TgeneIL1B

GO:0035690

cellular response to drug

19158679

TgeneIL1B

GO:0042102

positive regulation of T cell proliferation

1919436

TgeneIL1B

GO:0043122

regulation of I-kappaB kinase/NF-kappaB signaling

10748004

TgeneIL1B

GO:0045429

positive regulation of nitric oxide biosynthetic process

8383325

TgeneIL1B

GO:0045766

positive regulation of angiogenesis

25204733

TgeneIL1B

GO:0045893

positive regulation of transcription, DNA-templated

15100360

TgeneIL1B

GO:0050796

regulation of insulin secretion

8383325

TgeneIL1B

GO:0050995

negative regulation of lipid catabolic process

19032770

TgeneIL1B

GO:0050999

regulation of nitric-oxide synthase activity

15899045

TgeneIL1B

GO:0051044

positive regulation of membrane protein ectodomain proteolysis

18373975

TgeneIL1B

GO:0051091

positive regulation of DNA-binding transcription factor activity

10748004

TgeneIL1B

GO:0051092

positive regulation of NF-kappaB transcription factor activity

10383454|12958148|25327529

TgeneIL1B

GO:0060559

positive regulation of calcidiol 1-monooxygenase activity

16720713|17023519

TgeneIL1B

GO:0070372

regulation of ERK1 and ERK2 cascade

25204733

TgeneIL1B

GO:0070487

monocyte aggregation

15100360

TgeneIL1B

GO:0070498

interleukin-1-mediated signaling pathway

25327529

TgeneIL1B

GO:0070555

response to interleukin-1

29441883

TgeneIL1B

GO:0071310

cellular response to organic substance

19158679

TgeneIL1B

GO:0071407

cellular response to organic cyclic compound

21147091

TgeneIL1B

GO:0071639

positive regulation of monocyte chemotactic protein-1 production

19524870

TgeneIL1B

GO:1901224

positive regulation of NIK/NF-kappaB signaling

18390750

TgeneIL1B

GO:1902680

positive regulation of RNA biosynthetic process

29384235

TgeneIL1B

GO:1903140

regulation of establishment of endothelial barrier

25816133

TgeneIL1B

GO:1903597

negative regulation of gap junction assembly

11090614

TgeneIL1B

GO:2000556

positive regulation of T-helper 1 cell cytokine production

10653850

TgeneIL1B

GO:2001240

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

10748004


check buttonFusion gene breakpoints across ARL5A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across IL1B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-8524-01AARL5Achr2

152668871

-IL1Bchr2

113591152

-
ChimerDB4STADTCGA-CD-8524-01AARL5Achr2

152668871

-IL1Bchr2

113593821

-
ChimerDB4STADTCGA-CD-8524-01AARL5Achr2

152668871

-IL1Bchr2

113594435

-
ChimerDB4STADTCGA-CD-8524-01AARL5Achr2

152670683

-IL1Bchr2

113593821

-
ChimerDB4STADTCGA-CD-8524ARL5Achr2

152668870

-IL1Bchr2

113593821

-


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Fusion Gene ORF analysis for ARL5A-IL1B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000295087ENST00000263341ARL5Achr2

152668871

-IL1Bchr2

113593821

-
5CDS-5UTRENST00000295087ENST00000263341ARL5Achr2

152668871

-IL1Bchr2

113594435

-
5CDS-5UTRENST00000295087ENST00000263341ARL5Achr2

152670683

-IL1Bchr2

113593821

-
5CDS-5UTRENST00000295087ENST00000263341ARL5Achr2

152668870

-IL1Bchr2

113593821

-
5CDS-5UTRENST00000295087ENST00000491056ARL5Achr2

152668871

-IL1Bchr2

113591152

-
5CDS-5UTRENST00000295087ENST00000491056ARL5Achr2

152668871

-IL1Bchr2

113593821

-
5CDS-5UTRENST00000295087ENST00000491056ARL5Achr2

152670683

-IL1Bchr2

113593821

-
5CDS-5UTRENST00000295087ENST00000491056ARL5Achr2

152668870

-IL1Bchr2

113593821

-
5CDS-5UTRENST00000428992ENST00000263341ARL5Achr2

152668871

-IL1Bchr2

113593821

-
5CDS-5UTRENST00000428992ENST00000263341ARL5Achr2

152668871

-IL1Bchr2

113594435

-
5CDS-5UTRENST00000428992ENST00000263341ARL5Achr2

152670683

-IL1Bchr2

113593821

-
5CDS-5UTRENST00000428992ENST00000263341ARL5Achr2

152668870

-IL1Bchr2

113593821

-
5CDS-5UTRENST00000428992ENST00000491056ARL5Achr2

152668871

-IL1Bchr2

113591152

-
5CDS-5UTRENST00000428992ENST00000491056ARL5Achr2

152668871

-IL1Bchr2

113593821

-
5CDS-5UTRENST00000428992ENST00000491056ARL5Achr2

152670683

-IL1Bchr2

113593821

-
5CDS-5UTRENST00000428992ENST00000491056ARL5Achr2

152668870

-IL1Bchr2

113593821

-
5CDS-intronENST00000295087ENST00000491056ARL5Achr2

152668871

-IL1Bchr2

113594435

-
5CDS-intronENST00000428992ENST00000491056ARL5Achr2

152668871

-IL1Bchr2

113594435

-
Frame-shiftENST00000428992ENST00000263341ARL5Achr2

152668871

-IL1Bchr2

113591152

-
In-frameENST00000295087ENST00000263341ARL5Achr2

152668871

-IL1Bchr2

113591152

-
intron-3CDSENST00000487723ENST00000263341ARL5Achr2

152668871

-IL1Bchr2

113591152

-
intron-5UTRENST00000487723ENST00000263341ARL5Achr2

152668871

-IL1Bchr2

113593821

-
intron-5UTRENST00000487723ENST00000263341ARL5Achr2

152668871

-IL1Bchr2

113594435

-
intron-5UTRENST00000487723ENST00000263341ARL5Achr2

152670683

-IL1Bchr2

113593821

-
intron-5UTRENST00000487723ENST00000263341ARL5Achr2

152668870

-IL1Bchr2

113593821

-
intron-5UTRENST00000487723ENST00000491056ARL5Achr2

152668871

-IL1Bchr2

113591152

-
intron-5UTRENST00000487723ENST00000491056ARL5Achr2

152668871

-IL1Bchr2

113593821

-
intron-5UTRENST00000487723ENST00000491056ARL5Achr2

152670683

-IL1Bchr2

113593821

-
intron-5UTRENST00000487723ENST00000491056ARL5Achr2

152668870

-IL1Bchr2

113593821

-
intron-intronENST00000487723ENST00000491056ARL5Achr2

152668871

-IL1Bchr2

113594435

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000295087ARL5Achr2152668871-ENST00000263341IL1Bchr2113591152-19726511291361410

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000295087ENST00000263341ARL5Achr2152668871-IL1Bchr2113591152-0.0009082220.99909174

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Fusion Genomic Features for ARL5A-IL1B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ARL5A-IL1B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:152668871/chr2:113593821)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARL5A

Q9Y689

IL1B

P01584

FUNCTION: Lacks ADP-ribosylation enhancing activity. {ECO:0000250}.FUNCTION: Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells (PubMed:10653850). Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6 (PubMed:12794819). {ECO:0000269|PubMed:10653850, ECO:0000269|PubMed:12794819, ECO:0000269|PubMed:3920526}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARL5Achr2:152668871chr2:113591152ENST00000295087-4623_30113180.0Nucleotide bindingNote=GTP
HgeneARL5Achr2:152668871chr2:113591152ENST00000295087-4666_70113180.0Nucleotide bindingGTP
HgeneARL5Achr2:152668871chr2:113591152ENST00000428992-4623_3076143.0Nucleotide bindingNote=GTP
HgeneARL5Achr2:152668871chr2:113591152ENST00000428992-4666_7076143.0Nucleotide bindingGTP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARL5Achr2:152668871chr2:113591152ENST00000295087-46125_128113180.0Nucleotide bindingNote=GTP
HgeneARL5Achr2:152668871chr2:113591152ENST00000428992-46125_12876143.0Nucleotide bindingNote=GTP


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Fusion Gene Sequence for ARL5A-IL1B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>6610_6610_1_ARL5A-IL1B_ARL5A_chr2_152668871_ENST00000295087_IL1B_chr2_113591152_ENST00000263341_length(transcript)=1972nt_BP=651nt
GCGTGGTCGTCGCCACCGCAGCCGCCCGAGAGGAGCTGGGGGAGGACGGTGGCCCGCGAGGCTCGTCGCAGACAACGCGGCGGCGATGTC
CGCGAGCCAGGCGAGTGCCGCGGCGGCAGCGGCGGGGCCTTGCGCGCGGCAGGGCGGCCTGGGCTTCGGCCTCCCTCCGGTTCCCTGGAA
GCGGGCCCGCGACCAGCGCGGGAGCAGCAGCAGAGGCGGAGGCTCCAGCGCGTCTCTCTCCTCCCCCTCAGCCTGAGCCGGGGGAAGCCA
GGCGGCCCGGGTGTCTGGAGGGGGGGGGTCCGCTGCCCGAGAATGGGAATTCTCTTCACTAGAATATGGAGACTGTTCAATCACCAGGAG
CACAAAGTTATCATTGTTGGGCTGGATAATGCAGGGAAAACTACCATTCTTTACCAATTTTCTATGAATGAAGTTGTACATACATCTCCT
ACAATAGGAAGTAATGTAGAAGAGATAGTGATTAATAATACACGTTTCCTAATGTGGGATATTGGTGGCCAAGAATCTCTTCGTTCTTCC
TGGAACACTTACTATACTAACACAGAGTTTGTAATAGTTGTTGTGGACAGTACAGACAGAGAGAGGATTTCTGTAACTAGAGAAGAACTC
TATAAAATGTTAGCGCATGAGTGCTCCTTCCAGGACCTGGACCTCTGCCCTCTGGATGGCGGCATCCAGCTACGAATCTCCGACCACCAC
TACAGCAAGGGCTTCAGGCAGGCCGCGTCAGTTGTTGTGGCCATGGACAAGCTGAGGAAGATGCTGGTTCCCTGCCCACAGACCTTCCAG
GAGAATGACCTGAGCACCTTCTTTCCCTTCATCTTTGAAGAAGAACCTATCTTCTTCGACACATGGGATAACGAGGCTTATGTGCACGAT
GCACCTGTACGATCACTGAACTGCACGCTCCGGGACTCACAGCAAAAAAGCTTGGTGATGTCTGGTCCATATGAACTGAAAGCTCTCCAC
CTCCAGGGACAGGATATGGAGCAACAAGTGGTGTTCTCCATGTCCTTTGTACAAGGAGAAGAAAGTAATGACAAAATACCTGTGGCCTTG
GGCCTCAAGGAAAAGAATCTGTACCTGTCCTGCGTGTTGAAAGATGATAAGCCCACTCTACAGCTGGAGAGTGTAGATCCCAAAAATTAC
CCAAAGAAGAAGATGGAAAAGCGATTTGTCTTCAACAAGATAGAAATCAATAACAAGCTGGAATTTGAGTCTGCCCAGTTCCCCAACTGG
TACATCAGCACCTCTCAAGCAGAAAACATGCCCGTCTTCCTGGGAGGGACCAAAGGCGGCCAGGATATAACTGACTTCACCATGCAATTT
GTGTCTTCCTAAAGAGAGCTGTACCCAGAGAGTCCTGTGCTGAATGTGGACTCAATCCCTAGGGCTGGCAGAAAGGGAACAGAAAGGTTT
TTGAGTACGGCTATAGCCTGGACTTTCCTGTTGTCTACACCAATGCCCAACTGCCTGCCTTAGGGTAGTGCTAAGAGGATCTCCTGTCCA
TCAGCCAGGACAGTCAGCTCTCTCCTTTCAGGGCCAATCCCCAGCCCTTTTGTTGAGCCAGGCCTCTCTCACCTCTCCTACTCACTTAAA
GCCCGCCTGACAGAAACCACGGCCACATTTGGTTCTAAGAAACCCTCTGTCATTCGCTCCCACATTCTGATGAGCAACCGCTTCCCTATT
TATTTATTTATTTGTTTGTTTGTTTTATTCATTGGTCTAATTTATTCAAAGGGGGCAAGAAGTAGCAGTGTCTGTAAAAGAGCCTAGTTT
TTAATAGCTATGGAATCAATTCAATTTGGACTGGTGTGCTCTCTTTAAATCAAGTCCTTTAATTAAGACTGAAAATATATAAGCTCAGAT

>6610_6610_1_ARL5A-IL1B_ARL5A_chr2_152668871_ENST00000295087_IL1B_chr2_113591152_ENST00000263341_length(amino acids)=410AA_BP=174
MRAAGRPGLRPPSGSLEAGPRPAREQQQRRRLQRVSLLPLSLSRGKPGGPGVWRGGVRCPRMGILFTRIWRLFNHQEHKVIIVGLDNAGK
TTILYQFSMNEVVHTSPTIGSNVEEIVINNTRFLMWDIGGQESLRSSWNTYYTNTEFVIVVVDSTDRERISVTREELYKMLAHECSFQDL
DLCPLDGGIQLRISDHHYSKGFRQAASVVVAMDKLRKMLVPCPQTFQENDLSTFFPFIFEEEPIFFDTWDNEAYVHDAPVRSLNCTLRDS
QQKSLVMSGPYELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALGLKEKNLYLSCVLKDDKPTLQLESVDPKNYPKKKMEKRFVFNK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ARL5A-IL1B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARL5A-IL1B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARL5A-IL1B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource