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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:PLD5-PLA2R1 (FusionGDB2 ID:66111)

Fusion Gene Summary for PLD5-PLA2R1

Fusion gene summary

Fusion gene information	Fusion gene name: PLD5-PLA2R1
	Fusion gene ID: 66111
		Hgene	Tgene
	Gene symbol	PLD5	PLA2R1
	Gene ID	200150	22925
	Gene name	phospholipase D family member 5	phospholipase A2 receptor 1
	Synonyms	PLDC	CLEC13C\|PLA2-R\|PLA2G1R\|PLA2IR\|PLA2R
	Cytomap	1q43	2q24.2
	Type of gene	protein-coding	protein-coding
	Description	inactive phospholipase D5inactive PLD 5inactive choline phosphatase 5inactive phosphatidylcholine-hydrolyzing phospholipase D5	secretory phospholipase A2 receptor180 kDa secretory phospholipase A2 receptorC-type lectin domain family 13 member CM-type receptorphospholipase A2 receptor 1, 180kDphospholipase A2 receptor 1, 180kDa
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000536534, ENST00000442594, ENST00000427495, ENST00000474177,	ENST00000460710, ENST00000283243, ENST00000392771,
Fusion gene scores	* DoF score	5 X 3 X 5=75	2 X 4 X 3=24
	# samples	5	3
	** MAII score	log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/24*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: PLD5 [Title/Abstract] AND PLA2R1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	PLD5(242687390)-PLA2R1(160806287), # samples:2 PLD5(242687390)-PLA2R1(160808089), # samples:2
Anticipated loss of major functional domain due to fusion event.	PLD5-PLA2R1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	PLA2R1	GO:0072593	reactive oxygen species metabolic process	19197340

Fusion gene breakpoints across PLD5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PLA2R1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SKCM	TCGA-ER-A197-06A	PLD5	chr1	242687390	-	PLA2R1	chr2	160806287	-
ChimerDB4	SKCM	TCGA-ER-A197-06A	PLD5	chr1	242687390	-	PLA2R1	chr2	160808089	-

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Fusion Gene ORF analysis for PLD5-PLA2R1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000536534	ENST00000460710	PLD5	chr1	242687390	-	PLA2R1	chr2	160806287	-
5CDS-intron	ENST00000536534	ENST00000460710	PLD5	chr1	242687390	-	PLA2R1	chr2	160808089	-
5UTR-3CDS	ENST00000442594	ENST00000283243	PLD5	chr1	242687390	-	PLA2R1	chr2	160806287	-
5UTR-3CDS	ENST00000442594	ENST00000283243	PLD5	chr1	242687390	-	PLA2R1	chr2	160808089	-
5UTR-3CDS	ENST00000442594	ENST00000392771	PLD5	chr1	242687390	-	PLA2R1	chr2	160806287	-
5UTR-3CDS	ENST00000442594	ENST00000392771	PLD5	chr1	242687390	-	PLA2R1	chr2	160808089	-
5UTR-intron	ENST00000442594	ENST00000460710	PLD5	chr1	242687390	-	PLA2R1	chr2	160806287	-
5UTR-intron	ENST00000442594	ENST00000460710	PLD5	chr1	242687390	-	PLA2R1	chr2	160808089	-
Frame-shift	ENST00000536534	ENST00000283243	PLD5	chr1	242687390	-	PLA2R1	chr2	160808089	-
Frame-shift	ENST00000536534	ENST00000392771	PLD5	chr1	242687390	-	PLA2R1	chr2	160808089	-
In-frame	ENST00000536534	ENST00000283243	PLD5	chr1	242687390	-	PLA2R1	chr2	160806287	-
In-frame	ENST00000536534	ENST00000392771	PLD5	chr1	242687390	-	PLA2R1	chr2	160806287	-
intron-3CDS	ENST00000427495	ENST00000283243	PLD5	chr1	242687390	-	PLA2R1	chr2	160806287	-
intron-3CDS	ENST00000427495	ENST00000283243	PLD5	chr1	242687390	-	PLA2R1	chr2	160808089	-
intron-3CDS	ENST00000427495	ENST00000392771	PLD5	chr1	242687390	-	PLA2R1	chr2	160806287	-
intron-3CDS	ENST00000427495	ENST00000392771	PLD5	chr1	242687390	-	PLA2R1	chr2	160808089	-
intron-3CDS	ENST00000474177	ENST00000283243	PLD5	chr1	242687390	-	PLA2R1	chr2	160806287	-
intron-3CDS	ENST00000474177	ENST00000283243	PLD5	chr1	242687390	-	PLA2R1	chr2	160808089	-
intron-3CDS	ENST00000474177	ENST00000392771	PLD5	chr1	242687390	-	PLA2R1	chr2	160806287	-
intron-3CDS	ENST00000474177	ENST00000392771	PLD5	chr1	242687390	-	PLA2R1	chr2	160808089	-
intron-intron	ENST00000427495	ENST00000460710	PLD5	chr1	242687390	-	PLA2R1	chr2	160806287	-
intron-intron	ENST00000427495	ENST00000460710	PLD5	chr1	242687390	-	PLA2R1	chr2	160808089	-
intron-intron	ENST00000474177	ENST00000460710	PLD5	chr1	242687390	-	PLA2R1	chr2	160806287	-
intron-intron	ENST00000474177	ENST00000460710	PLD5	chr1	242687390	-	PLA2R1	chr2	160808089	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000536534	PLD5	chr1	242687390	-	ENST00000283243	PLA2R1	chr2	160806287	-	5210	431	242	1282	346
ENST00000536534	PLD5	chr1	242687390	-	ENST00000392771	PLA2R1	chr2	160806287	-	1844	431	242	865	207

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000536534	ENST00000283243	PLD5	chr1	242687390	-	PLA2R1	chr2	160806287	-	0.000329307	0.99967074
ENST00000536534	ENST00000392771	PLD5	chr1	242687390	-	PLA2R1	chr2	160806287	-	0.006337799	0.99366224

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Fusion Genomic Features for PLD5-PLA2R1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PLD5-PLA2R1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:242687390/chr2:160806287)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

PLA2R1

chr1:242687390

chr2:160806287

ENST00000283243

1257_1378

1180

1464.0

Domain

C-type lectin 8

Tgene

PLA2R1

chr1:242687390

chr2:160806287

ENST00000392771

1257_1378

1180

1325.0

Domain

C-type lectin 8

Tgene

PLA2R1

chr1:242687390

chr2:160806287

ENST00000283243

1436_1442

1180

1464.0

Motif

Note=Endocytosis signal

Tgene

PLA2R1

chr1:242687390

chr2:160806287

ENST00000392771

1436_1442

1180

1325.0

Motif

Note=Endocytosis signal

Tgene

PLA2R1

chr1:242687390

chr2:160806287

ENST00000283243

1419_1463

1180

1464.0

Topological domain

Cytoplasmic

Tgene

PLA2R1

chr1:242687390

chr2:160806287

ENST00000392771

1419_1463

1180

1325.0

Topological domain

Cytoplasmic

Tgene

PLA2R1

chr1:242687390

chr2:160806287

ENST00000283243

1398_1418

1180

1464.0

Transmembrane

Helical

Tgene

PLA2R1

chr1:242687390

chr2:160806287

ENST00000392771

1398_1418

1180

1325.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PLD5

chr1:242687390

chr2:160806287

ENST00000427495

215_242

475.0

Domain

Note=PLD phosphodiesterase 1

Hgene

PLD5

chr1:242687390

chr2:160806287

ENST00000427495

434_460

475.0

Domain

Note=PLD phosphodiesterase 2

Hgene

PLD5

chr1:242687390

chr2:160806287

ENST00000442594

215_242

445.0

Domain

Note=PLD phosphodiesterase 1

Hgene

PLD5

chr1:242687390

chr2:160806287

ENST00000442594

434_460

445.0

Domain

Note=PLD phosphodiesterase 2

Hgene

PLD5

chr1:242687390

chr2:160806287

ENST00000536534

215_242

537.0

Domain

Note=PLD phosphodiesterase 1

Hgene

PLD5

chr1:242687390

chr2:160806287

ENST00000536534

434_460

537.0

Domain

Note=PLD phosphodiesterase 2

Hgene

PLD5

chr1:242687390

chr2:160806287

ENST00000427495

69_89

475.0

Transmembrane

Helical

Hgene

PLD5

chr1:242687390

chr2:160806287

ENST00000442594

69_89

445.0

Transmembrane

Helical

Hgene

PLD5

chr1:242687390

chr2:160806287

ENST00000536534

69_89

537.0

Transmembrane

Helical

Tgene

PLA2R1

chr1:242687390

chr2:160806287

ENST00000283243

1121_1232

1180

1464.0

Domain

C-type lectin 7

Tgene

PLA2R1

chr1:242687390

chr2:160806287

ENST00000283243

173_221

1180

1464.0

Domain

Fibronectin type-II

Tgene

PLA2R1

chr1:242687390

chr2:160806287

ENST00000283243

238_355

1180

1464.0

Domain

C-type lectin 1

Tgene

PLA2R1

chr1:242687390

chr2:160806287

ENST00000283243

385_502

1180

1464.0

Domain

C-type lectin 2

Tgene

PLA2R1

chr1:242687390

chr2:160806287

ENST00000283243

38_161

1180

1464.0

Domain

Ricin B-type lectin

Tgene

PLA2R1

chr1:242687390

chr2:160806287

ENST00000283243

522_643

1180

1464.0

Domain

C-type lectin 3

Tgene

PLA2R1

chr1:242687390

chr2:160806287

ENST00000283243

673_797

1180

1464.0

Domain

C-type lectin 4

Tgene

PLA2R1

chr1:242687390

chr2:160806287

ENST00000283243

819_938

1180

1464.0

Domain

C-type lectin 5

Tgene

PLA2R1

chr1:242687390

chr2:160806287

ENST00000283243

965_1096

1180

1464.0

Domain

C-type lectin 6

Tgene

PLA2R1

chr1:242687390

chr2:160806287

ENST00000392771

1121_1232

1180

1325.0

Domain

C-type lectin 7

Tgene

PLA2R1

chr1:242687390

chr2:160806287

ENST00000392771

173_221

1180

1325.0

Domain

Fibronectin type-II

Tgene

PLA2R1

chr1:242687390

chr2:160806287

ENST00000392771

238_355

1180

1325.0

Domain

C-type lectin 1

Tgene

PLA2R1

chr1:242687390

chr2:160806287

ENST00000392771

385_502

1180

1325.0

Domain

C-type lectin 2

Tgene

PLA2R1

chr1:242687390

chr2:160806287

ENST00000392771

38_161

1180

1325.0

Domain

Ricin B-type lectin

Tgene

PLA2R1

chr1:242687390

chr2:160806287

ENST00000392771

522_643

1180

1325.0

Domain

C-type lectin 3

Tgene

PLA2R1

chr1:242687390

chr2:160806287

ENST00000392771

673_797

1180

1325.0

Domain

C-type lectin 4

Tgene

PLA2R1

chr1:242687390

chr2:160806287

ENST00000392771

819_938

1180

1325.0

Domain

C-type lectin 5

Tgene

PLA2R1

chr1:242687390

chr2:160806287

ENST00000392771

965_1096

1180

1325.0

Domain

C-type lectin 6

Tgene

PLA2R1

chr1:242687390

chr2:160806287

ENST00000283243

21_1397

1180

1464.0

Topological domain

Extracellular

Tgene

PLA2R1

chr1:242687390

chr2:160806287

ENST00000392771

21_1397

1180

1325.0

Topological domain

Extracellular

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Fusion Gene Sequence for PLD5-PLA2R1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>66111_66111_1_PLD5-PLA2R1_PLD5_chr1_242687390_ENST00000536534_PLA2R1_chr2_160806287_ENST00000283243_length(transcript)=5210nt_BP=431nt
CACCTCGCCCTCCCTCCTTCCGCCCCGCGCCTCCCGCGATCGCCCCCTCCCGCCCGGCCGCGCTCCCAGCTGGCGCTCAGCACCCCGCGC
TCCCCGCGCCCGCTCGCTCCTCCAGCTCCTCCAGCTCAGTCTCCAGCTCCACCTCCGGCTCCCGCTGGGCCTCCCGCTCGCCCTCCGCGC
CCGGCTCCCCGCGCGCCCGTCCCGAGTCCGCTGCTCGCCGGCGGCCGCCCGGTCATGTCAGGATGGAGATCCGGCAGCACGAGTGGCTCT
CGGCCTCCCCCCATGAGGGCTTCGAGCAGATGAGGCTCAAAAGCCGCCCCAAGGAGCCCTCCCCAAGCCTGACCCGAGTGGGCGCGAACT
TCTACAGCAGCGTCAAGCAGCAGGACTACAGCGCCAGCGTCTGGCTTCGGAGGAAAGACAAGCTGGAGCACAATGGTCTTAATTTTGACT
GGTCTGATGGCACCAAATCTTCTTTCACTTTTTGGAAAGATGAGGAGTCCTCCCTCCTTGGTGACTGCGTTTTTGCCGACAGCAACGGAC
GCTGGCATAGCACAGCCTGCGAGTCATTTCTGCAAGGTGCCATTTGTCATGTGCCACCTGAAACAAGACAATCTGAACACCCAGAGTTGT
GCTCAGAAACATCTATTCCCTGGATAAAATTTAAAAGTAATTGCTACAGTTTTTCTACAGTCCTAGACAGTATGAGTTTTGAGGCTGCTC
ATGAATTTTGCAAAAAGGAAGGTTCTAATCTTTTAACAATCAAGGATGAGGCTGAAAATGCATTTCTCCTAGAAGAGCTGTTTGCTTTTG
GTTCTTCTGTCCAGATGGTTTGGTTGAATGCTCAATTTGATGGTAACAATGAAACCATAAAGTGGTTTGATGGAACTCCCACAGACCAGT
CAAACTGGGGCATTCGGAAGCCAGACACAGACTACTTCAAGCCCCATCATTGTGTTGCCTTGAGGATCCCTGAAGGATTATGGCAGCTAT
CCCCGTGTCAAGAAAAAAAAGGCTTTATATGTAAAATGGAGGCAGATATTCACACTGCAGAGGCGCTGCCAGAAAAAGGACCAAGTCACA
GCATCATTCCTCTTGCGGTTGTACTGACACTGATAGTCATTGTGGCCATTTGCACACTTTCCTTCTGCATATACAAGCATAACGGTGGCT
TCTTCAGGAGACTTGCAGGGTTTCGGAATCCTTACTATCCTGCAACCAACTTTAGTACAGTATATTTAGAAGAAAATATTCTCATTTCTG
ATCTTGAGAAGAGTGACCAATAATAATGAGGTCAGAGAATGCCACAGACACCAGGGTAAGTAAAGAAGACTAAACAGGAGTCTCATCTGT
CTTTCCCTTTACAGCACAGATGCCATTAGAATGTGAATTGGGTCACTATTTTAATTATTCTTGAAGTGATTACTGGTTTTGAATCTTAAC
CAAATCAGATGGGTTTTGATTTATTCATTTCCCTAAACTGTGATCCATTCTTAAAAGGGGTAAATTATGCATTGGTTATTTTTCAGAAAG
ACAAGAACTATTAAAAGAAACTCCCTATTGAAAACTCTGAAATCAATGCGAATAATAGTTTTTGCATTAATGTATCTCTACTAAAATTTG
GGGGAATTTTAAAACTAATCTGGTATCTATTCAGACATTTACCTGCACTCGTACCATTAAGAAAGACAGAAAGAAGCAAAAAAAAATTAA
TCTTGTATATGAGAGGAAAAGGAAAGGGCTTCTGAGAGGATTCTTAGTTGTTTCTTTTGAATTCACTTTTAATAGCAGGATTTGGAAAAT
ACTAATTTCTGTGCTTAAGGGTCACAGGTTCTGGGCTCTCAACTGATATTTAAGGTGACATTCATTTTTATTAGGTCTAACATCTCAAGC
TAAAGGAGAAAGAAAAATACCTTCTTTTAAATGGCAAAGACCTTCATTAGCAGCACACTTTTATAAACAACCATATAGTTAAAATGTGGC
CTTAAACTTTCAATTACTAAATGATGATTAAGTTGGATATTTTAAAATGTCTTATACATAAGCTTAAAGTAATATATTGAAACTTTAACA
GTTGTACTGTTAAAACTCATGGACTTTCTGAAAAACTAAATATATAAAATAATATGTAACACTCTTAATAACTGGAAGATATAAAATGTA
ACTTGGATTTAAAGGAGAAGAGCTAAAGATCTGAATTATAGTCTCATTAGAACCAGACAGATGTTGTTGAGAAGTACTAAATAAATTAGT
AATCTAGATATCTTTATTATGTAAATGAGTTTAGGTGTTCTATTTAATAAACTATTTTCTGGGAACGATCTCCTTTTATATTAGTCTAGT
TAGTGTAGATGGTAAATAATGATTATGATACTGTCTGTAAATAAAAAATTACAGATTTTATTTTCCTTTATTAGTTCCTTATAAAGAAAA
CAGCTTCATAATCAATATCTAAAAATTTACTCATTACATAACTGTTTATTGAATTTTATCAAGAAAAAAGTGTACTGAGCATGGTGGCAC
GCACCTGTAGTCCCAGCTACTTAGGAGGCTGAGGGAAGAGGATCAACTGAGCCCAGAAGTTGAAGGCTGCAGTGAGCTATGGTTGCACCA
CTGCACTCCTGCCTGGGCAACTGAATGAGACCCCACCTCAAAAAAGTGCTGTTCTAGAAACAGAGGTACTAAGGTGAGCAACTTGGGGTA
AGGGCTATCTTTTCATGCCACTTATTTTCTAATGAGGGAAAATTGACAGTAACTCAGTAAAGAAATGCATATGCATAAAATAGCAAGTGG
TTATGAAAATGAAGTAAGGTTCCATGATAGAGAGAAACTGGGGGACTCTCAGGGCCTCCCTGAGAGTGTGCATTTTAATTATTACAACCA
ACTGCCTCAAAACCAGTGGCCACTAATCACAAGGGGGAGCTCTGAGAGAAAGTATGAATGAATTTCTAAGAGGCAAACCATCATCATTAG
AAATACAATTTGAAGAGCATACCACTAAGAATGGAATCCTTGTGGCCTGCAACAGTTAATCCAGCTTCCAAAAGCAGCTCTTTGCTACTG
TTATAATAATTTACACACTGGGACAGTCTACCTCCATAATTTTTTTAAGTATTGGGACTTCATTTTTTAAAAGATATTATATTATGTGGC
AGTTGCATATTTATGACTCAAAAAATAATTGGCTTGAACTCACCAGATGGTATAAAAGCCCAATTTAACCATCTTTTGAGTGGAATTAAA
GTTCTGTTCTTTTCAATGGACTTGGTAAAAACTGCTAATCAACCAGCCTTCCAGTCAAGGTATATAGTCACACATAATAATTTGACAAAA
TACACCATTAGGAAAGTGATTTTGCAGAAAGAAGCTGTATTGCTTCTCAGTGCTCCATACTTTGATGTTTAGTATTGAACAACATCTCCA
GATAATCTGGACCCATGGACAGATCACACACTTCTTGCCATTACTGAATTTGCAGAAATAGTACTGAAGTATTCTGCTACATTTTTATAT
TTGCATTTTTTTTGAAACTTTTTTTCATTTTTTTTTTTTTTTTTTGGAGATGGAGTCTTGCTCTGTTGCCAGGCAGGAGTACAGTGGCAT
GATCTCAGCTCACTGCAACCTTCAACTGCCTGGTTCGAGCAAGTTTCCTGCCTCAGCCTCCCGAGTAGCTGTGATTACAGGCACATGCCA
CCATGCCCAGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGTCCAGGATGGTCTCGATCTCCTGATCTCGTGATCCAC
CCGCCCCAGCCTCCCAAAGTGCTAAGATTACAGGCATGAGCCACCGCACCTGGCCTCATCTGTATTTTTAATGTGAACTAGATTTTATAG
CTATAATTCGAAAAGAAAAAAAAGTAGCAGGTAATGGGTATATTATACACTATTTGCGTGATGGTTACACCAGACTTTACCACTACATAC
TGTATTTATGTAACAAAATTACACTTGTACTCCTTACATTTATGCCAAAAAAGCGGCAGGATCACAAATTCACACATAGTTAATGTGCCC
CTCCAACAGTCAATTATGTTCTATGACTAACCTGAGGATCTTTATAGAATCTGAGTAATGGAAATGCCTGGGTTTTTCCATTTAACAATA
TATTGGGCTCTTACAGTTACAACAGTCTTCTTTCGGGTTAAATATTTCTTCTCTTGAAGGGTCCACTCCTTATTAAAGATAAGATTGAAC
TGAATGTTTACTTAAACGTTCAGTCTTTTGGAGTTTCTTTACTCTTCTCAAAATGGTGGTTGGATATATAAGAACTTGCTGTGTCCTGGT
AGTGTTGAGGGGAGAAGGTGACAACTTACTGTGGATGTATGTTAGCTGGTGTCCACTGAGAATAGCTGTCTGGCCTCACTCCTGGGAATT
CTGCTGGCATCTGCTGTGAAGTCTGCAGTTGCTTTAATCTGTAGTCTGTTCTCTTTGATTTGGCCTCATTCTGGCTGTCCCTGGTGCTGT
CTTATCTCTTGAGAACTGGCTGTGTCTCCTGTTGAATTCCCTATCCGAACACTGCAGTTCTTGGCTACAAGGCAGTCACTTCACCCCTGC
AGTGGTGAGATCCCATTAGCTACCATTAGCTACTCTTTTCGTCCAGAAAGGCGAAATGCCATAGCAAACAATCCCACAGTCTTGGTGGAT
TAACACAGCAAAGGTTTATTTCTCACCCACACCTGCATGGGCTGGCAAGAGGACTTTGCTCTGTTCAGTCATTCATGGGTCCATGCTTCT
CCTATATAGCCAGCCCTCTGTCTCCTAAGGCCTGGAGTCCTCCATGGGCCTCCAATCTGTGGCTGACAGAGGATGTTGACTTGAGACCCA
TCTTTGATTCATTATGGAGCTTCCACAGGCTGTTGAAATCCTCTAAGTCAAAAGTCCTCAAACTGGGGACACATGCCTAAGGAATACAGG
AGCATGGGTATTTAAGAAACTTAATTTCCAGAATCTTCATGTATATTTTTTCTTAAAACTGATTTACCTGAGAGCACCCCTGGTTCTTCT
TTCCCACCTCTCTTTACACAAATGCCTTTCTCTACCTTTAAAAAGAAAAAGAAAAAGAAATGGCTTTCATTTCAGATCTTACTATGGGAA

>66111_66111_1_PLD5-PLA2R1_PLD5_chr1_242687390_ENST00000536534_PLA2R1_chr2_160806287_ENST00000283243_length(amino acids)=346AA_BP=63
MEIRQHEWLSASPHEGFEQMRLKSRPKEPSPSLTRVGANFYSSVKQQDYSASVWLRRKDKLEHNGLNFDWSDGTKSSFTFWKDEESSLLG
DCVFADSNGRWHSTACESFLQGAICHVPPETRQSEHPELCSETSIPWIKFKSNCYSFSTVLDSMSFEAAHEFCKKEGSNLLTIKDEAENA
FLLEELFAFGSSVQMVWLNAQFDGNNETIKWFDGTPTDQSNWGIRKPDTDYFKPHHCVALRIPEGLWQLSPCQEKKGFICKMEADIHTAE

--------------------------------------------------------------
>66111_66111_2_PLD5-PLA2R1_PLD5_chr1_242687390_ENST00000536534_PLA2R1_chr2_160806287_ENST00000392771_length(transcript)=1844nt_BP=431nt
CACCTCGCCCTCCCTCCTTCCGCCCCGCGCCTCCCGCGATCGCCCCCTCCCGCCCGGCCGCGCTCCCAGCTGGCGCTCAGCACCCCGCGC
TCCCCGCGCCCGCTCGCTCCTCCAGCTCCTCCAGCTCAGTCTCCAGCTCCACCTCCGGCTCCCGCTGGGCCTCCCGCTCGCCCTCCGCGC
CCGGCTCCCCGCGCGCCCGTCCCGAGTCCGCTGCTCGCCGGCGGCCGCCCGGTCATGTCAGGATGGAGATCCGGCAGCACGAGTGGCTCT
CGGCCTCCCCCCATGAGGGCTTCGAGCAGATGAGGCTCAAAAGCCGCCCCAAGGAGCCCTCCCCAAGCCTGACCCGAGTGGGCGCGAACT
TCTACAGCAGCGTCAAGCAGCAGGACTACAGCGCCAGCGTCTGGCTTCGGAGGAAAGACAAGCTGGAGCACAATGGTCTTAATTTTGACT
GGTCTGATGGCACCAAATCTTCTTTCACTTTTTGGAAAGATGAGGAGTCCTCCCTCCTTGGTGACTGCGTTTTTGCCGACAGCAACGGAC
GCTGGCATAGCACAGCCTGCGAGTCATTTCTGCAAGGTGCCATTTGTCATGTGCCACCTGAAACAAGACAATCTGAACACCCAGAGTTGT
GCTCAGAAACATCTATTCCCTGGATAAAATTTAAAAGTAATTGCTACAGTTTTTCTACAGTCCTAGACAGTATGAGTTTTGAGGCTGCTC
ATGAATTTTGCAAAAAGGAAGGTTCTAATCTTTTAACAATCAAGGATGAGGCTGAAAATGCATTTCTCCTAGAAGAGCTGTTTGCTTTTG
GTTCTTCTGTCCAGATGGTTTGGTTGAATGCTCAATTTGATGGTAACAGTAAGTGATTTGGGTAGAGGAGAGGACATAAATAAATACATG
GTTGTTAAAGCTGATGATAATGGCATCTGTGAGCCAGAAAACTCTCCTTGGATACGTTTTCTGAGAAAAAATAGCATGAAGCCTAAAGCC
ATTTCTTCCAAAAACAACATTGCAACCCTTTTCTTTACCCTTTTGTCTTTTAAAATAATCCCAGAACACCAAAAATAAAAACAAACAATA
ACATGTTTATCTTTACCCTTAGCAGGAAGATGCTTGGCTGGAACTTTGTGTTCACAGACTTAGTCATTGCATACCAAAACCATATTTACT
GGAAAATATCCCAGGTTTCTAAATGTTATAAAAGCACAATAGAGTTATGGAAATGTTTCCATGATGAACTGTGCTGTTAGGATTCTTATT
TGCTACTCATAAAAACCAGAGTTTGTAATAAAATGGAAGCATGGTATTCTTTTCTTTATGTAATTGATGGTTATTGAAAGGTACTTGTGA
AGAAAATTATTTTAATTGGTATGGAGAGCTTGTTACAGTGGTGTACCAAGGTTGGGGGTGAGCCTACCCTTTCGAGGAGGAGTATTTTAA
TCACCAACATTGTTTAGAATTTCAAGCAGATGGTGATAATAAAAAGCAGACCAACTTTTAGTTAGCTGTATTGTTAGTTTTAAATTATTT
TCAGACAATACACTATTGCCCACACATGGGATGGACTCTCCTACCGCCCCTACCCCCTTGGTACATGGCTGGCTTGGTATTAAAGAAATT
CACTGTAAAATCTTTTTAGAAAGTGAGCCATTTTGTAATGATGAAGATGTTAGGACTTCAAAGGATTTTTCTTTACTCGATTAGTTTTGT
TTATCAAATGATTTCTTTAAATCGATTATATATATATATGGAATATTTCAAAATTCAAACTGTCACATTAAGAAACATGATAACCTAAAT

>66111_66111_2_PLD5-PLA2R1_PLD5_chr1_242687390_ENST00000536534_PLA2R1_chr2_160806287_ENST00000392771_length(amino acids)=207AA_BP=63
MEIRQHEWLSASPHEGFEQMRLKSRPKEPSPSLTRVGANFYSSVKQQDYSASVWLRRKDKLEHNGLNFDWSDGTKSSFTFWKDEESSLLG
DCVFADSNGRWHSTACESFLQGAICHVPPETRQSEHPELCSETSIPWIKFKSNCYSFSTVLDSMSFEAAHEFCKKEGSNLLTIKDEAENA

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for PLD5-PLA2R1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for PLD5-PLA2R1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for PLD5-PLA2R1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source