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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PLEKHA1-TACC2 (FusionGDB2 ID:66156)

Fusion Gene Summary for PLEKHA1-TACC2

check button Fusion gene summary
Fusion gene informationFusion gene name: PLEKHA1-TACC2
Fusion gene ID: 66156
HgeneTgene
Gene symbol

PLEKHA1

TACC2

Gene ID

59338

10579

Gene namepleckstrin homology domain containing A1transforming acidic coiled-coil containing protein 2
SynonymsTAPP1AZU-1|ECTACC
Cytomap

10q26.13

10q26.13

Type of geneprotein-codingprotein-coding
Descriptionpleckstrin homology domain-containing family A member 1pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1tandem PH domain-containing protein 1transforming acidic coiled-coil-containing protein 2anti zuai-1
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000368988, ENST00000368989, 
ENST00000368990, ENST00000433307, 
ENST00000538022, ENST00000494222, 
ENST00000493951, ENST00000260733, 
ENST00000360561, ENST00000369000, 
ENST00000369001, ENST00000369004, 
ENST00000369005, ENST00000513429, 
ENST00000334433, ENST00000358010, 
ENST00000368999, ENST00000453444, 
ENST00000515273, ENST00000515603, 
Fusion gene scores* DoF score8 X 7 X 7=39211 X 16 X 4=704
# samples 914
** MAII scorelog2(9/392*10)=-2.12285674778553
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/704*10)=-2.33014860169233
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PLEKHA1 [Title/Abstract] AND TACC2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPLEKHA1(124183779)-TACC2(124013506), # samples:1
Anticipated loss of major functional domain due to fusion event.PLEKHA1-TACC2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePLEKHA1

GO:0014065

phosphatidylinositol 3-kinase signaling

12101241

HgenePLEKHA1

GO:0031529

ruffle organization

15485858

HgenePLEKHA1

GO:0045184

establishment of protein localization

14516276

HgenePLEKHA1

GO:0050853

B cell receptor signaling pathway

12101241

HgenePLEKHA1

GO:0070301

cellular response to hydrogen peroxide

14516276


check buttonFusion gene breakpoints across PLEKHA1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TACC2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CESCTCGA-DS-A3LQ-01APLEKHA1chr10

124183779

+TACC2chr10

124013506

+


Top

Fusion Gene ORF analysis for PLEKHA1-TACC2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000368988ENST00000493951PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
5CDS-intronENST00000368989ENST00000493951PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
5CDS-intronENST00000368990ENST00000493951PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
5CDS-intronENST00000433307ENST00000493951PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
5CDS-intronENST00000538022ENST00000493951PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
Frame-shiftENST00000368988ENST00000260733PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
Frame-shiftENST00000368988ENST00000360561PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
Frame-shiftENST00000368988ENST00000369000PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
Frame-shiftENST00000368988ENST00000369001PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
Frame-shiftENST00000368988ENST00000369004PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
Frame-shiftENST00000368988ENST00000369005PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
Frame-shiftENST00000368988ENST00000513429PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
Frame-shiftENST00000368989ENST00000260733PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
Frame-shiftENST00000368989ENST00000360561PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
Frame-shiftENST00000368989ENST00000369000PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
Frame-shiftENST00000368989ENST00000369001PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
Frame-shiftENST00000368989ENST00000369004PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
Frame-shiftENST00000368989ENST00000369005PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
Frame-shiftENST00000368989ENST00000513429PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
Frame-shiftENST00000368990ENST00000260733PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
Frame-shiftENST00000368990ENST00000360561PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
Frame-shiftENST00000368990ENST00000369000PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
Frame-shiftENST00000368990ENST00000369001PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
Frame-shiftENST00000368990ENST00000369004PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
Frame-shiftENST00000368990ENST00000369005PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
Frame-shiftENST00000368990ENST00000513429PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
Frame-shiftENST00000433307ENST00000260733PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
Frame-shiftENST00000433307ENST00000360561PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
Frame-shiftENST00000433307ENST00000369000PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
Frame-shiftENST00000433307ENST00000369001PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
Frame-shiftENST00000433307ENST00000369004PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
Frame-shiftENST00000433307ENST00000369005PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
Frame-shiftENST00000433307ENST00000513429PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
Frame-shiftENST00000538022ENST00000260733PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
Frame-shiftENST00000538022ENST00000360561PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
Frame-shiftENST00000538022ENST00000369000PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
Frame-shiftENST00000538022ENST00000369001PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
Frame-shiftENST00000538022ENST00000369004PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
Frame-shiftENST00000538022ENST00000369005PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
Frame-shiftENST00000538022ENST00000513429PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
In-frameENST00000368988ENST00000334433PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
In-frameENST00000368988ENST00000358010PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
In-frameENST00000368988ENST00000368999PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
In-frameENST00000368988ENST00000453444PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
In-frameENST00000368988ENST00000515273PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
In-frameENST00000368988ENST00000515603PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
In-frameENST00000368989ENST00000334433PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
In-frameENST00000368989ENST00000358010PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
In-frameENST00000368989ENST00000368999PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
In-frameENST00000368989ENST00000453444PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
In-frameENST00000368989ENST00000515273PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
In-frameENST00000368989ENST00000515603PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
In-frameENST00000368990ENST00000334433PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
In-frameENST00000368990ENST00000358010PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
In-frameENST00000368990ENST00000368999PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
In-frameENST00000368990ENST00000453444PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
In-frameENST00000368990ENST00000515273PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
In-frameENST00000368990ENST00000515603PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
In-frameENST00000433307ENST00000334433PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
In-frameENST00000433307ENST00000358010PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
In-frameENST00000433307ENST00000368999PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
In-frameENST00000433307ENST00000453444PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
In-frameENST00000433307ENST00000515273PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
In-frameENST00000433307ENST00000515603PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
In-frameENST00000538022ENST00000334433PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
In-frameENST00000538022ENST00000358010PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
In-frameENST00000538022ENST00000368999PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
In-frameENST00000538022ENST00000453444PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
In-frameENST00000538022ENST00000515273PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
In-frameENST00000538022ENST00000515603PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
intron-3CDSENST00000494222ENST00000260733PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
intron-3CDSENST00000494222ENST00000334433PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
intron-3CDSENST00000494222ENST00000358010PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
intron-3CDSENST00000494222ENST00000360561PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
intron-3CDSENST00000494222ENST00000368999PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
intron-3CDSENST00000494222ENST00000369000PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
intron-3CDSENST00000494222ENST00000369001PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
intron-3CDSENST00000494222ENST00000369004PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
intron-3CDSENST00000494222ENST00000369005PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
intron-3CDSENST00000494222ENST00000453444PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
intron-3CDSENST00000494222ENST00000513429PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
intron-3CDSENST00000494222ENST00000515273PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
intron-3CDSENST00000494222ENST00000515603PLEKHA1chr10

124183779

+TACC2chr10

124013506

+
intron-intronENST00000494222ENST00000493951PLEKHA1chr10

124183779

+TACC2chr10

124013506

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000368990PLEKHA1chr10124183779+ENST00000515273TACC2chr10124013506+1232877131889252
ENST00000368990PLEKHA1chr10124183779+ENST00000515603TACC2chr10124013506+1235877131889252
ENST00000368990PLEKHA1chr10124183779+ENST00000453444TACC2chr10124013506+1232877131889252
ENST00000368990PLEKHA1chr10124183779+ENST00000358010TACC2chr10124013506+1427877131889252
ENST00000368990PLEKHA1chr10124183779+ENST00000334433TACC2chr10124013506+1427877131889252
ENST00000368990PLEKHA1chr10124183779+ENST00000368999TACC2chr10124013506+1370877131889252
ENST00000368988PLEKHA1chr10124183779+ENST00000515273TACC2chr10124013506+1224869123881252
ENST00000368988PLEKHA1chr10124183779+ENST00000515603TACC2chr10124013506+1227869123881252
ENST00000368988PLEKHA1chr10124183779+ENST00000453444TACC2chr10124013506+1224869123881252
ENST00000368988PLEKHA1chr10124183779+ENST00000358010TACC2chr10124013506+1419869123881252
ENST00000368988PLEKHA1chr10124183779+ENST00000334433TACC2chr10124013506+1419869123881252
ENST00000368988PLEKHA1chr10124183779+ENST00000368999TACC2chr10124013506+1362869123881252
ENST00000368989PLEKHA1chr10124183779+ENST00000515273TACC2chr10124013506+1209854108866252
ENST00000368989PLEKHA1chr10124183779+ENST00000515603TACC2chr10124013506+1212854108866252
ENST00000368989PLEKHA1chr10124183779+ENST00000453444TACC2chr10124013506+1209854108866252
ENST00000368989PLEKHA1chr10124183779+ENST00000358010TACC2chr10124013506+1404854108866252
ENST00000368989PLEKHA1chr10124183779+ENST00000334433TACC2chr10124013506+1404854108866252
ENST00000368989PLEKHA1chr10124183779+ENST00000368999TACC2chr10124013506+1347854108866252
ENST00000538022PLEKHA1chr10124183779+ENST00000515273TACC2chr10124013506+1310955209967252
ENST00000538022PLEKHA1chr10124183779+ENST00000515603TACC2chr10124013506+1313955209967252
ENST00000538022PLEKHA1chr10124183779+ENST00000453444TACC2chr10124013506+1310955209967252
ENST00000538022PLEKHA1chr10124183779+ENST00000358010TACC2chr10124013506+1505955209967252
ENST00000538022PLEKHA1chr10124183779+ENST00000334433TACC2chr10124013506+1505955209967252
ENST00000538022PLEKHA1chr10124183779+ENST00000368999TACC2chr10124013506+1448955209967252
ENST00000433307PLEKHA1chr10124183779+ENST00000515273TACC2chr10124013506+112376822780252
ENST00000433307PLEKHA1chr10124183779+ENST00000515603TACC2chr10124013506+112676822780252
ENST00000433307PLEKHA1chr10124183779+ENST00000453444TACC2chr10124013506+112376822780252
ENST00000433307PLEKHA1chr10124183779+ENST00000358010TACC2chr10124013506+131876822780252
ENST00000433307PLEKHA1chr10124183779+ENST00000334433TACC2chr10124013506+131876822780252
ENST00000433307PLEKHA1chr10124183779+ENST00000368999TACC2chr10124013506+126176822780252

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000368990ENST00000515273PLEKHA1chr10124183779+TACC2chr10124013506+0.0008069810.999193
ENST00000368990ENST00000515603PLEKHA1chr10124183779+TACC2chr10124013506+0.0007825680.9992174
ENST00000368990ENST00000453444PLEKHA1chr10124183779+TACC2chr10124013506+0.0008069810.999193
ENST00000368990ENST00000358010PLEKHA1chr10124183779+TACC2chr10124013506+0.0005665460.99943346
ENST00000368990ENST00000334433PLEKHA1chr10124183779+TACC2chr10124013506+0.0005665460.99943346
ENST00000368990ENST00000368999PLEKHA1chr10124183779+TACC2chr10124013506+0.0005924820.99940753
ENST00000368988ENST00000515273PLEKHA1chr10124183779+TACC2chr10124013506+0.0008328880.9991671
ENST00000368988ENST00000515603PLEKHA1chr10124183779+TACC2chr10124013506+0.0008081830.9991918
ENST00000368988ENST00000453444PLEKHA1chr10124183779+TACC2chr10124013506+0.0008328880.9991671
ENST00000368988ENST00000358010PLEKHA1chr10124183779+TACC2chr10124013506+0.000568820.9994312
ENST00000368988ENST00000334433PLEKHA1chr10124183779+TACC2chr10124013506+0.000568820.9994312
ENST00000368988ENST00000368999PLEKHA1chr10124183779+TACC2chr10124013506+0.0006006340.9993993
ENST00000368989ENST00000515273PLEKHA1chr10124183779+TACC2chr10124013506+0.0008574490.9991425
ENST00000368989ENST00000515603PLEKHA1chr10124183779+TACC2chr10124013506+0.000823910.9991761
ENST00000368989ENST00000453444PLEKHA1chr10124183779+TACC2chr10124013506+0.0008574490.9991425
ENST00000368989ENST00000358010PLEKHA1chr10124183779+TACC2chr10124013506+0.0005859870.9994141
ENST00000368989ENST00000334433PLEKHA1chr10124183779+TACC2chr10124013506+0.0005859870.9994141
ENST00000368989ENST00000368999PLEKHA1chr10124183779+TACC2chr10124013506+0.0006089410.9993911
ENST00000538022ENST00000515273PLEKHA1chr10124183779+TACC2chr10124013506+0.0004222810.9995777
ENST00000538022ENST00000515603PLEKHA1chr10124183779+TACC2chr10124013506+0.00040710.99959296
ENST00000538022ENST00000453444PLEKHA1chr10124183779+TACC2chr10124013506+0.0004222810.9995777
ENST00000538022ENST00000358010PLEKHA1chr10124183779+TACC2chr10124013506+0.0003557550.9996443
ENST00000538022ENST00000334433PLEKHA1chr10124183779+TACC2chr10124013506+0.0003557550.9996443
ENST00000538022ENST00000368999PLEKHA1chr10124183779+TACC2chr10124013506+0.0003581950.9996418
ENST00000433307ENST00000515273PLEKHA1chr10124183779+TACC2chr10124013506+0.0009576420.99904233
ENST00000433307ENST00000515603PLEKHA1chr10124183779+TACC2chr10124013506+0.0009190520.9990809
ENST00000433307ENST00000453444PLEKHA1chr10124183779+TACC2chr10124013506+0.0009576420.99904233
ENST00000433307ENST00000358010PLEKHA1chr10124183779+TACC2chr10124013506+0.0006077440.9993923
ENST00000433307ENST00000334433PLEKHA1chr10124183779+TACC2chr10124013506+0.0006077440.9993923
ENST00000433307ENST00000368999PLEKHA1chr10124183779+TACC2chr10124013506+0.0006367870.99936324

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Fusion Genomic Features for PLEKHA1-TACC2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PLEKHA1chr10124183779+TACC2chr10124013505+0.0001721990.99982774
PLEKHA1chr10124183779+TACC2chr10124013505+0.0001721990.99982774

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PLEKHA1-TACC2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:124183779/chr10:124013506)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePLEKHA1chr10:124183779chr10:124013506ENST00000368990+9127_112248405.0DomainPH 1
HgenePLEKHA1chr10:124183779chr10:124013506ENST00000433307+8117_112248405.0DomainPH 1
HgenePLEKHA1chr10:124183779chr10:124013506ENST00000538022+10147_112248461.6666666666667DomainPH 1
TgeneTACC2chr10:124183779chr10:124013506ENST0000026073315172675_270310051027.0Coiled coilOntology_term=ECO:0000255
TgeneTACC2chr10:124183779chr10:124013506ENST0000026073315172746_294710051027.0Coiled coilOntology_term=ECO:0000255
TgeneTACC2chr10:124183779chr10:124013506ENST0000035801017192675_270310731095.0Coiled coilOntology_term=ECO:0000255
TgeneTACC2chr10:124183779chr10:124013506ENST0000035801017192746_294710731095.0Coiled coilOntology_term=ECO:0000255
TgeneTACC2chr10:124183779chr10:124013506ENST0000036056114162675_2703975997.0Coiled coilOntology_term=ECO:0000255
TgeneTACC2chr10:124183779chr10:124013506ENST0000036056114162746_2947975997.0Coiled coilOntology_term=ECO:0000255
TgeneTACC2chr10:124183779chr10:124013506ENST0000036900014162675_2703550572.0Coiled coilOntology_term=ECO:0000255
TgeneTACC2chr10:124183779chr10:124013506ENST0000036900014162746_2947550572.0Coiled coilOntology_term=ECO:0000255
TgeneTACC2chr10:124183779chr10:124013506ENST0000051342918202675_270310731095.0Coiled coilOntology_term=ECO:0000255
TgeneTACC2chr10:124183779chr10:124013506ENST0000051342918202746_294710731095.0Coiled coilOntology_term=ECO:0000255
TgeneTACC2chr10:124183779chr10:124013506ENST0000026073315171956_201610051027.0Compositional biasNote=Pro-rich
TgeneTACC2chr10:124183779chr10:124013506ENST0000026073315172420_242310051027.0Compositional biasNote=Poly-Lys
TgeneTACC2chr10:124183779chr10:124013506ENST0000035801017191956_201610731095.0Compositional biasNote=Pro-rich
TgeneTACC2chr10:124183779chr10:124013506ENST0000035801017192420_242310731095.0Compositional biasNote=Poly-Lys
TgeneTACC2chr10:124183779chr10:124013506ENST0000036056114161956_2016975997.0Compositional biasNote=Pro-rich
TgeneTACC2chr10:124183779chr10:124013506ENST0000036056114162420_2423975997.0Compositional biasNote=Poly-Lys
TgeneTACC2chr10:124183779chr10:124013506ENST0000036900014161956_2016550572.0Compositional biasNote=Pro-rich
TgeneTACC2chr10:124183779chr10:124013506ENST0000036900014162420_2423550572.0Compositional biasNote=Poly-Lys
TgeneTACC2chr10:124183779chr10:124013506ENST0000051342918201956_201610731095.0Compositional biasNote=Pro-rich
TgeneTACC2chr10:124183779chr10:124013506ENST0000051342918202420_242310731095.0Compositional biasNote=Poly-Lys
TgeneTACC2chr10:124183779chr10:124013506ENST0000026073315172315_240310051027.0DomainNote=SPAZ
TgeneTACC2chr10:124183779chr10:124013506ENST0000035801017192315_240310731095.0DomainNote=SPAZ
TgeneTACC2chr10:124183779chr10:124013506ENST0000036056114162315_2403975997.0DomainNote=SPAZ
TgeneTACC2chr10:124183779chr10:124013506ENST0000036900014162315_2403550572.0DomainNote=SPAZ
TgeneTACC2chr10:124183779chr10:124013506ENST0000051342918202315_240310731095.0DomainNote=SPAZ

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePLEKHA1chr10:124183779chr10:124013506ENST00000368990+912191_289248405.0DomainPH 2
HgenePLEKHA1chr10:124183779chr10:124013506ENST00000433307+811191_289248405.0DomainPH 2
HgenePLEKHA1chr10:124183779chr10:124013506ENST00000538022+1014191_289248461.6666666666667DomainPH 2
TgeneTACC2chr10:124183779chr10:124013506ENST0000033443320222675_270329272949.0Coiled coilOntology_term=ECO:0000255
TgeneTACC2chr10:124183779chr10:124013506ENST0000033443320222746_294729272949.0Coiled coilOntology_term=ECO:0000255
TgeneTACC2chr10:124183779chr10:124013506ENST0000036900521232675_270329272949.0Coiled coilOntology_term=ECO:0000255
TgeneTACC2chr10:124183779chr10:124013506ENST0000036900521232746_294729272949.0Coiled coilOntology_term=ECO:0000255
TgeneTACC2chr10:124183779chr10:124013506ENST000002607331517482_54910051027.0Compositional biasNote=Pro-rich
TgeneTACC2chr10:124183779chr10:124013506ENST0000033443320221956_201629272949.0Compositional biasNote=Pro-rich
TgeneTACC2chr10:124183779chr10:124013506ENST0000033443320222420_242329272949.0Compositional biasNote=Poly-Lys
TgeneTACC2chr10:124183779chr10:124013506ENST000003344332022482_54929272949.0Compositional biasNote=Pro-rich
TgeneTACC2chr10:124183779chr10:124013506ENST000003580101719482_54910731095.0Compositional biasNote=Pro-rich
TgeneTACC2chr10:124183779chr10:124013506ENST000003605611416482_549975997.0Compositional biasNote=Pro-rich
TgeneTACC2chr10:124183779chr10:124013506ENST000003690001416482_549550572.0Compositional biasNote=Pro-rich
TgeneTACC2chr10:124183779chr10:124013506ENST0000036900521231956_201629272949.0Compositional biasNote=Pro-rich
TgeneTACC2chr10:124183779chr10:124013506ENST0000036900521232420_242329272949.0Compositional biasNote=Poly-Lys
TgeneTACC2chr10:124183779chr10:124013506ENST000003690052123482_54929272949.0Compositional biasNote=Pro-rich
TgeneTACC2chr10:124183779chr10:124013506ENST000005134291820482_54910731095.0Compositional biasNote=Pro-rich
TgeneTACC2chr10:124183779chr10:124013506ENST0000033443320222315_240329272949.0DomainNote=SPAZ
TgeneTACC2chr10:124183779chr10:124013506ENST0000036900521232315_240329272949.0DomainNote=SPAZ


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Fusion Gene Sequence for PLEKHA1-TACC2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>66156_66156_1_PLEKHA1-TACC2_PLEKHA1_chr10_124183779_ENST00000368988_TACC2_chr10_124013506_ENST00000334433_length(transcript)=1419nt_BP=869nt
GTGCGCAGTGCGCGGGCTGGCCGTCGCGGACGCCGCTCCGGGCAGCCGAGCCTCTGTGGGAGCCGGGGCCGCGGCGGCGCGGGTGCTCCG
GGCCGAGGCCGCGTGTAATGTTCAAGCTCAGAAATGCCTTATGTGGATCGTCAGAATCGCATTTGTGGTTTTCTAGACATTGAAGAAAAT
GAAAACAGTGGGAAATTTCTTCGAAGGTACTTCATACTGGATACCAGAGAAGATAGTTTCGTGTGGTACATGGATAATCCACAGAACCTA
CCTTCTGGATCATCACGTGTTGGAGCCATTAAGCTTACCTACATTTCAAAGGTTAGCGATGCTACTAAGCTAAGGCCAAAGGCGGAGTTC
TGTTTTGTTATGAATGCAGGAATGAGGAAGTACTTCCTACAAGCCAATGATCAGCAGGACCTAGTGGAATGGGTAAATGTGTTAAACAAA
GCTATAAAAATTACAGTACCAAAGCAGTCAGACTCACAGCCTAATTCTGATAACCTAAGTCGCCATGGTGAATGTGGGAAAAAGCAAGTG
TCTTACAGAACTGATATTGTTGGTGGCGTACCCATCATTACTCCCACTCAGAAAGAAGAAGTAAATGAATGTGGTGAAAGTATTGACAGA
AATAATCTGAAACGGTCACAAAGCCATCTTCCTTACTTTACTCCTAAACCACCTCAAGATAGTGCGGTTATCAAAGCTGGATATTGTGTA
AAACAAGGAGCAGTGATGAAAAACTGGAAGAGAAGATATTTTCAATTGGATGAAAACACAATAGGCTACTTCAAATCTGAACTGGAAAAG
GAACCTCTTCGTGTAATACCACTTAAAGAGGTTCATAAAGTCCAGGAATGTAAGCAAAGAATAAAGAAATAGAAGAACTCACCAAGATTT
GTGACGAACTGATTGCCAAAATGGGGAAAAGCTAACTCTGAACCGAATGTTTTGGACTTAACTGTTGCGTGCAATATGACCGTCGGCACA
CTGCTGTTCCTCCAGTTCCATGGACAGGTTCTGTTTTCACTTTTTCGTATGCACTACTGTATTTCCTTTCTAAATAAAATTGATTTGATT
GTATGCAGTACTAAGGAGACTATCAGAATTTCTTGCTATTGGTTTGCATTTTCCTAGTATAATTCATAGCAAGTTGACCTCAGAGTTCCT
GTATCAGGGAGATTGTCTGATTCTCTAATAAAAGACACATTGCTGACCTTGGCCTTGCCCTTTGTACACAAGTTCCCAGGGTGAGCAGCT
TTTGGATTTAATATGAACATGTACAGCGTGCATAGGGACTCTTGCCTTAAGGAGTGTAAACTTGATCTGCATTTGCTGATTTGTTTTTAA

>66156_66156_1_PLEKHA1-TACC2_PLEKHA1_chr10_124183779_ENST00000368988_TACC2_chr10_124013506_ENST00000334433_length(amino acids)=252AA_BP=
MPYVDRQNRICGFLDIEENENSGKFLRRYFILDTREDSFVWYMDNPQNLPSGSSRVGAIKLTYISKVSDATKLRPKAEFCFVMNAGMRKY
FLQANDQQDLVEWVNVLNKAIKITVPKQSDSQPNSDNLSRHGECGKKQVSYRTDIVGGVPIITPTQKEEVNECGESIDRNNLKRSQSHLP

--------------------------------------------------------------
>66156_66156_2_PLEKHA1-TACC2_PLEKHA1_chr10_124183779_ENST00000368988_TACC2_chr10_124013506_ENST00000358010_length(transcript)=1419nt_BP=869nt
GTGCGCAGTGCGCGGGCTGGCCGTCGCGGACGCCGCTCCGGGCAGCCGAGCCTCTGTGGGAGCCGGGGCCGCGGCGGCGCGGGTGCTCCG
GGCCGAGGCCGCGTGTAATGTTCAAGCTCAGAAATGCCTTATGTGGATCGTCAGAATCGCATTTGTGGTTTTCTAGACATTGAAGAAAAT
GAAAACAGTGGGAAATTTCTTCGAAGGTACTTCATACTGGATACCAGAGAAGATAGTTTCGTGTGGTACATGGATAATCCACAGAACCTA
CCTTCTGGATCATCACGTGTTGGAGCCATTAAGCTTACCTACATTTCAAAGGTTAGCGATGCTACTAAGCTAAGGCCAAAGGCGGAGTTC
TGTTTTGTTATGAATGCAGGAATGAGGAAGTACTTCCTACAAGCCAATGATCAGCAGGACCTAGTGGAATGGGTAAATGTGTTAAACAAA
GCTATAAAAATTACAGTACCAAAGCAGTCAGACTCACAGCCTAATTCTGATAACCTAAGTCGCCATGGTGAATGTGGGAAAAAGCAAGTG
TCTTACAGAACTGATATTGTTGGTGGCGTACCCATCATTACTCCCACTCAGAAAGAAGAAGTAAATGAATGTGGTGAAAGTATTGACAGA
AATAATCTGAAACGGTCACAAAGCCATCTTCCTTACTTTACTCCTAAACCACCTCAAGATAGTGCGGTTATCAAAGCTGGATATTGTGTA
AAACAAGGAGCAGTGATGAAAAACTGGAAGAGAAGATATTTTCAATTGGATGAAAACACAATAGGCTACTTCAAATCTGAACTGGAAAAG
GAACCTCTTCGTGTAATACCACTTAAAGAGGTTCATAAAGTCCAGGAATGTAAGCAAAGAATAAAGAAATAGAAGAACTCACCAAGATTT
GTGACGAACTGATTGCCAAAATGGGGAAAAGCTAACTCTGAACCGAATGTTTTGGACTTAACTGTTGCGTGCAATATGACCGTCGGCACA
CTGCTGTTCCTCCAGTTCCATGGACAGGTTCTGTTTTCACTTTTTCGTATGCACTACTGTATTTCCTTTCTAAATAAAATTGATTTGATT
GTATGCAGTACTAAGGAGACTATCAGAATTTCTTGCTATTGGTTTGCATTTTCCTAGTATAATTCATAGCAAGTTGACCTCAGAGTTCCT
GTATCAGGGAGATTGTCTGATTCTCTAATAAAAGACACATTGCTGACCTTGGCCTTGCCCTTTGTACACAAGTTCCCAGGGTGAGCAGCT
TTTGGATTTAATATGAACATGTACAGCGTGCATAGGGACTCTTGCCTTAAGGAGTGTAAACTTGATCTGCATTTGCTGATTTGTTTTTAA

>66156_66156_2_PLEKHA1-TACC2_PLEKHA1_chr10_124183779_ENST00000368988_TACC2_chr10_124013506_ENST00000358010_length(amino acids)=252AA_BP=
MPYVDRQNRICGFLDIEENENSGKFLRRYFILDTREDSFVWYMDNPQNLPSGSSRVGAIKLTYISKVSDATKLRPKAEFCFVMNAGMRKY
FLQANDQQDLVEWVNVLNKAIKITVPKQSDSQPNSDNLSRHGECGKKQVSYRTDIVGGVPIITPTQKEEVNECGESIDRNNLKRSQSHLP

--------------------------------------------------------------
>66156_66156_3_PLEKHA1-TACC2_PLEKHA1_chr10_124183779_ENST00000368988_TACC2_chr10_124013506_ENST00000368999_length(transcript)=1362nt_BP=869nt
GTGCGCAGTGCGCGGGCTGGCCGTCGCGGACGCCGCTCCGGGCAGCCGAGCCTCTGTGGGAGCCGGGGCCGCGGCGGCGCGGGTGCTCCG
GGCCGAGGCCGCGTGTAATGTTCAAGCTCAGAAATGCCTTATGTGGATCGTCAGAATCGCATTTGTGGTTTTCTAGACATTGAAGAAAAT
GAAAACAGTGGGAAATTTCTTCGAAGGTACTTCATACTGGATACCAGAGAAGATAGTTTCGTGTGGTACATGGATAATCCACAGAACCTA
CCTTCTGGATCATCACGTGTTGGAGCCATTAAGCTTACCTACATTTCAAAGGTTAGCGATGCTACTAAGCTAAGGCCAAAGGCGGAGTTC
TGTTTTGTTATGAATGCAGGAATGAGGAAGTACTTCCTACAAGCCAATGATCAGCAGGACCTAGTGGAATGGGTAAATGTGTTAAACAAA
GCTATAAAAATTACAGTACCAAAGCAGTCAGACTCACAGCCTAATTCTGATAACCTAAGTCGCCATGGTGAATGTGGGAAAAAGCAAGTG
TCTTACAGAACTGATATTGTTGGTGGCGTACCCATCATTACTCCCACTCAGAAAGAAGAAGTAAATGAATGTGGTGAAAGTATTGACAGA
AATAATCTGAAACGGTCACAAAGCCATCTTCCTTACTTTACTCCTAAACCACCTCAAGATAGTGCGGTTATCAAAGCTGGATATTGTGTA
AAACAAGGAGCAGTGATGAAAAACTGGAAGAGAAGATATTTTCAATTGGATGAAAACACAATAGGCTACTTCAAATCTGAACTGGAAAAG
GAACCTCTTCGTGTAATACCACTTAAAGAGGTTCATAAAGTCCAGGAATGTAAGCAAAGAATAAAGAAATAGAAGAACTCACCAAGATTT
GTGACGAACTGATTGCCAAAATGGGGAAAAGCTAACTCTGAACCGAATGTTTTGGACTTAACTGTTGCGTGCAATATGACCGTCGGCACA
CTGCTGTTCCTCCAGTTCCATGGACAGGTTCTGTTTTCACTTTTTCGTATGCACTACTGTATTTCCTTTCTAAATAAAATTGATTTGATT
GTATGCAGTACTAAGGAGACTATCAGAATTTCTTGCTATTGGTTTGCATTTTCCTAGTATAATTCATAGCAAGTTGACCTCAGAGTTCCT
GTATCAGGGAGATTGTCTGATTCTCTAATAAAAGACACATTGCTGACCTTGGCCTTGCCCTTTGTACACAAGTTCCCAGGGTGAGCAGCT
TTTGGATTTAATATGAACATGTACAGCGTGCATAGGGACTCTTGCCTTAAGGAGTGTAAACTTGATCTGCATTTGCTGATTTGTTTTTAA

>66156_66156_3_PLEKHA1-TACC2_PLEKHA1_chr10_124183779_ENST00000368988_TACC2_chr10_124013506_ENST00000368999_length(amino acids)=252AA_BP=
MPYVDRQNRICGFLDIEENENSGKFLRRYFILDTREDSFVWYMDNPQNLPSGSSRVGAIKLTYISKVSDATKLRPKAEFCFVMNAGMRKY
FLQANDQQDLVEWVNVLNKAIKITVPKQSDSQPNSDNLSRHGECGKKQVSYRTDIVGGVPIITPTQKEEVNECGESIDRNNLKRSQSHLP

--------------------------------------------------------------
>66156_66156_4_PLEKHA1-TACC2_PLEKHA1_chr10_124183779_ENST00000368988_TACC2_chr10_124013506_ENST00000453444_length(transcript)=1224nt_BP=869nt
GTGCGCAGTGCGCGGGCTGGCCGTCGCGGACGCCGCTCCGGGCAGCCGAGCCTCTGTGGGAGCCGGGGCCGCGGCGGCGCGGGTGCTCCG
GGCCGAGGCCGCGTGTAATGTTCAAGCTCAGAAATGCCTTATGTGGATCGTCAGAATCGCATTTGTGGTTTTCTAGACATTGAAGAAAAT
GAAAACAGTGGGAAATTTCTTCGAAGGTACTTCATACTGGATACCAGAGAAGATAGTTTCGTGTGGTACATGGATAATCCACAGAACCTA
CCTTCTGGATCATCACGTGTTGGAGCCATTAAGCTTACCTACATTTCAAAGGTTAGCGATGCTACTAAGCTAAGGCCAAAGGCGGAGTTC
TGTTTTGTTATGAATGCAGGAATGAGGAAGTACTTCCTACAAGCCAATGATCAGCAGGACCTAGTGGAATGGGTAAATGTGTTAAACAAA
GCTATAAAAATTACAGTACCAAAGCAGTCAGACTCACAGCCTAATTCTGATAACCTAAGTCGCCATGGTGAATGTGGGAAAAAGCAAGTG
TCTTACAGAACTGATATTGTTGGTGGCGTACCCATCATTACTCCCACTCAGAAAGAAGAAGTAAATGAATGTGGTGAAAGTATTGACAGA
AATAATCTGAAACGGTCACAAAGCCATCTTCCTTACTTTACTCCTAAACCACCTCAAGATAGTGCGGTTATCAAAGCTGGATATTGTGTA
AAACAAGGAGCAGTGATGAAAAACTGGAAGAGAAGATATTTTCAATTGGATGAAAACACAATAGGCTACTTCAAATCTGAACTGGAAAAG
GAACCTCTTCGTGTAATACCACTTAAAGAGGTTCATAAAGTCCAGGAATGTAAGCAAAGAATAAAGAAATAGAAGAACTCACCAAGATTT
GTGACGAACTGATTGCCAAAATGGGGAAAAGCTAACTCTGAACCGAATGTTTTGGACTTAACTGTTGCGTGCAATATGACCGTCGGCACA
CTGCTGTTCCTCCAGTTCCATGGACAGGTTCTGTTTTCACTTTTTCGTATGCACTACTGTATTTCCTTTCTAAATAAAATTGATTTGATT
GTATGCAGTACTAAGGAGACTATCAGAATTTCTTGCTATTGGTTTGCATTTTCCTAGTATAATTCATAGCAAGTTGACCTCAGAGTTCCT

>66156_66156_4_PLEKHA1-TACC2_PLEKHA1_chr10_124183779_ENST00000368988_TACC2_chr10_124013506_ENST00000453444_length(amino acids)=252AA_BP=
MPYVDRQNRICGFLDIEENENSGKFLRRYFILDTREDSFVWYMDNPQNLPSGSSRVGAIKLTYISKVSDATKLRPKAEFCFVMNAGMRKY
FLQANDQQDLVEWVNVLNKAIKITVPKQSDSQPNSDNLSRHGECGKKQVSYRTDIVGGVPIITPTQKEEVNECGESIDRNNLKRSQSHLP

--------------------------------------------------------------
>66156_66156_5_PLEKHA1-TACC2_PLEKHA1_chr10_124183779_ENST00000368988_TACC2_chr10_124013506_ENST00000515273_length(transcript)=1224nt_BP=869nt
GTGCGCAGTGCGCGGGCTGGCCGTCGCGGACGCCGCTCCGGGCAGCCGAGCCTCTGTGGGAGCCGGGGCCGCGGCGGCGCGGGTGCTCCG
GGCCGAGGCCGCGTGTAATGTTCAAGCTCAGAAATGCCTTATGTGGATCGTCAGAATCGCATTTGTGGTTTTCTAGACATTGAAGAAAAT
GAAAACAGTGGGAAATTTCTTCGAAGGTACTTCATACTGGATACCAGAGAAGATAGTTTCGTGTGGTACATGGATAATCCACAGAACCTA
CCTTCTGGATCATCACGTGTTGGAGCCATTAAGCTTACCTACATTTCAAAGGTTAGCGATGCTACTAAGCTAAGGCCAAAGGCGGAGTTC
TGTTTTGTTATGAATGCAGGAATGAGGAAGTACTTCCTACAAGCCAATGATCAGCAGGACCTAGTGGAATGGGTAAATGTGTTAAACAAA
GCTATAAAAATTACAGTACCAAAGCAGTCAGACTCACAGCCTAATTCTGATAACCTAAGTCGCCATGGTGAATGTGGGAAAAAGCAAGTG
TCTTACAGAACTGATATTGTTGGTGGCGTACCCATCATTACTCCCACTCAGAAAGAAGAAGTAAATGAATGTGGTGAAAGTATTGACAGA
AATAATCTGAAACGGTCACAAAGCCATCTTCCTTACTTTACTCCTAAACCACCTCAAGATAGTGCGGTTATCAAAGCTGGATATTGTGTA
AAACAAGGAGCAGTGATGAAAAACTGGAAGAGAAGATATTTTCAATTGGATGAAAACACAATAGGCTACTTCAAATCTGAACTGGAAAAG
GAACCTCTTCGTGTAATACCACTTAAAGAGGTTCATAAAGTCCAGGAATGTAAGCAAAGAATAAAGAAATAGAAGAACTCACCAAGATTT
GTGACGAACTGATTGCCAAAATGGGGAAAAGCTAACTCTGAACCGAATGTTTTGGACTTAACTGTTGCGTGCAATATGACCGTCGGCACA
CTGCTGTTCCTCCAGTTCCATGGACAGGTTCTGTTTTCACTTTTTCGTATGCACTACTGTATTTCCTTTCTAAATAAAATTGATTTGATT
GTATGCAGTACTAAGGAGACTATCAGAATTTCTTGCTATTGGTTTGCATTTTCCTAGTATAATTCATAGCAAGTTGACCTCAGAGTTCCT

>66156_66156_5_PLEKHA1-TACC2_PLEKHA1_chr10_124183779_ENST00000368988_TACC2_chr10_124013506_ENST00000515273_length(amino acids)=252AA_BP=
MPYVDRQNRICGFLDIEENENSGKFLRRYFILDTREDSFVWYMDNPQNLPSGSSRVGAIKLTYISKVSDATKLRPKAEFCFVMNAGMRKY
FLQANDQQDLVEWVNVLNKAIKITVPKQSDSQPNSDNLSRHGECGKKQVSYRTDIVGGVPIITPTQKEEVNECGESIDRNNLKRSQSHLP

--------------------------------------------------------------
>66156_66156_6_PLEKHA1-TACC2_PLEKHA1_chr10_124183779_ENST00000368988_TACC2_chr10_124013506_ENST00000515603_length(transcript)=1227nt_BP=869nt
GTGCGCAGTGCGCGGGCTGGCCGTCGCGGACGCCGCTCCGGGCAGCCGAGCCTCTGTGGGAGCCGGGGCCGCGGCGGCGCGGGTGCTCCG
GGCCGAGGCCGCGTGTAATGTTCAAGCTCAGAAATGCCTTATGTGGATCGTCAGAATCGCATTTGTGGTTTTCTAGACATTGAAGAAAAT
GAAAACAGTGGGAAATTTCTTCGAAGGTACTTCATACTGGATACCAGAGAAGATAGTTTCGTGTGGTACATGGATAATCCACAGAACCTA
CCTTCTGGATCATCACGTGTTGGAGCCATTAAGCTTACCTACATTTCAAAGGTTAGCGATGCTACTAAGCTAAGGCCAAAGGCGGAGTTC
TGTTTTGTTATGAATGCAGGAATGAGGAAGTACTTCCTACAAGCCAATGATCAGCAGGACCTAGTGGAATGGGTAAATGTGTTAAACAAA
GCTATAAAAATTACAGTACCAAAGCAGTCAGACTCACAGCCTAATTCTGATAACCTAAGTCGCCATGGTGAATGTGGGAAAAAGCAAGTG
TCTTACAGAACTGATATTGTTGGTGGCGTACCCATCATTACTCCCACTCAGAAAGAAGAAGTAAATGAATGTGGTGAAAGTATTGACAGA
AATAATCTGAAACGGTCACAAAGCCATCTTCCTTACTTTACTCCTAAACCACCTCAAGATAGTGCGGTTATCAAAGCTGGATATTGTGTA
AAACAAGGAGCAGTGATGAAAAACTGGAAGAGAAGATATTTTCAATTGGATGAAAACACAATAGGCTACTTCAAATCTGAACTGGAAAAG
GAACCTCTTCGTGTAATACCACTTAAAGAGGTTCATAAAGTCCAGGAATGTAAGCAAAGAATAAAGAAATAGAAGAACTCACCAAGATTT
GTGACGAACTGATTGCCAAAATGGGGAAAAGCTAACTCTGAACCGAATGTTTTGGACTTAACTGTTGCGTGCAATATGACCGTCGGCACA
CTGCTGTTCCTCCAGTTCCATGGACAGGTTCTGTTTTCACTTTTTCGTATGCACTACTGTATTTCCTTTCTAAATAAAATTGATTTGATT
GTATGCAGTACTAAGGAGACTATCAGAATTTCTTGCTATTGGTTTGCATTTTCCTAGTATAATTCATAGCAAGTTGACCTCAGAGTTCCT

>66156_66156_6_PLEKHA1-TACC2_PLEKHA1_chr10_124183779_ENST00000368988_TACC2_chr10_124013506_ENST00000515603_length(amino acids)=252AA_BP=
MPYVDRQNRICGFLDIEENENSGKFLRRYFILDTREDSFVWYMDNPQNLPSGSSRVGAIKLTYISKVSDATKLRPKAEFCFVMNAGMRKY
FLQANDQQDLVEWVNVLNKAIKITVPKQSDSQPNSDNLSRHGECGKKQVSYRTDIVGGVPIITPTQKEEVNECGESIDRNNLKRSQSHLP

--------------------------------------------------------------
>66156_66156_7_PLEKHA1-TACC2_PLEKHA1_chr10_124183779_ENST00000368989_TACC2_chr10_124013506_ENST00000334433_length(transcript)=1404nt_BP=854nt
TGGGAGCCGGGGCCGCGGCGGCGCGGGTGCTCCGGGCCGAGGCCGCGGTAAAGTTTAGCTTGAAGAACGCGGCCGCGCTGGAGCAGGGTG
TAATGTTCAAGCTCAGAAATGCCTTATGTGGATCGTCAGAATCGCATTTGTGGTTTTCTAGACATTGAAGAAAATGAAAACAGTGGGAAA
TTTCTTCGAAGGTACTTCATACTGGATACCAGAGAAGATAGTTTCGTGTGGTACATGGATAATCCACAGAACCTACCTTCTGGATCATCA
CGTGTTGGAGCCATTAAGCTTACCTACATTTCAAAGGTTAGCGATGCTACTAAGCTAAGGCCAAAGGCGGAGTTCTGTTTTGTTATGAAT
GCAGGAATGAGGAAGTACTTCCTACAAGCCAATGATCAGCAGGACCTAGTGGAATGGGTAAATGTGTTAAACAAAGCTATAAAAATTACA
GTACCAAAGCAGTCAGACTCACAGCCTAATTCTGATAACCTAAGTCGCCATGGTGAATGTGGGAAAAAGCAAGTGTCTTACAGAACTGAT
ATTGTTGGTGGCGTACCCATCATTACTCCCACTCAGAAAGAAGAAGTAAATGAATGTGGTGAAAGTATTGACAGAAATAATCTGAAACGG
TCACAAAGCCATCTTCCTTACTTTACTCCTAAACCACCTCAAGATAGTGCGGTTATCAAAGCTGGATATTGTGTAAAACAAGGAGCAGTG
ATGAAAAACTGGAAGAGAAGATATTTTCAATTGGATGAAAACACAATAGGCTACTTCAAATCTGAACTGGAAAAGGAACCTCTTCGTGTA
ATACCACTTAAAGAGGTTCATAAAGTCCAGGAATGTAAGCAAAGAATAAAGAAATAGAAGAACTCACCAAGATTTGTGACGAACTGATTG
CCAAAATGGGGAAAAGCTAACTCTGAACCGAATGTTTTGGACTTAACTGTTGCGTGCAATATGACCGTCGGCACACTGCTGTTCCTCCAG
TTCCATGGACAGGTTCTGTTTTCACTTTTTCGTATGCACTACTGTATTTCCTTTCTAAATAAAATTGATTTGATTGTATGCAGTACTAAG
GAGACTATCAGAATTTCTTGCTATTGGTTTGCATTTTCCTAGTATAATTCATAGCAAGTTGACCTCAGAGTTCCTGTATCAGGGAGATTG
TCTGATTCTCTAATAAAAGACACATTGCTGACCTTGGCCTTGCCCTTTGTACACAAGTTCCCAGGGTGAGCAGCTTTTGGATTTAATATG
AACATGTACAGCGTGCATAGGGACTCTTGCCTTAAGGAGTGTAAACTTGATCTGCATTTGCTGATTTGTTTTTAAAAAAACAAGAAATGC

>66156_66156_7_PLEKHA1-TACC2_PLEKHA1_chr10_124183779_ENST00000368989_TACC2_chr10_124013506_ENST00000334433_length(amino acids)=252AA_BP=
MPYVDRQNRICGFLDIEENENSGKFLRRYFILDTREDSFVWYMDNPQNLPSGSSRVGAIKLTYISKVSDATKLRPKAEFCFVMNAGMRKY
FLQANDQQDLVEWVNVLNKAIKITVPKQSDSQPNSDNLSRHGECGKKQVSYRTDIVGGVPIITPTQKEEVNECGESIDRNNLKRSQSHLP

--------------------------------------------------------------
>66156_66156_8_PLEKHA1-TACC2_PLEKHA1_chr10_124183779_ENST00000368989_TACC2_chr10_124013506_ENST00000358010_length(transcript)=1404nt_BP=854nt
TGGGAGCCGGGGCCGCGGCGGCGCGGGTGCTCCGGGCCGAGGCCGCGGTAAAGTTTAGCTTGAAGAACGCGGCCGCGCTGGAGCAGGGTG
TAATGTTCAAGCTCAGAAATGCCTTATGTGGATCGTCAGAATCGCATTTGTGGTTTTCTAGACATTGAAGAAAATGAAAACAGTGGGAAA
TTTCTTCGAAGGTACTTCATACTGGATACCAGAGAAGATAGTTTCGTGTGGTACATGGATAATCCACAGAACCTACCTTCTGGATCATCA
CGTGTTGGAGCCATTAAGCTTACCTACATTTCAAAGGTTAGCGATGCTACTAAGCTAAGGCCAAAGGCGGAGTTCTGTTTTGTTATGAAT
GCAGGAATGAGGAAGTACTTCCTACAAGCCAATGATCAGCAGGACCTAGTGGAATGGGTAAATGTGTTAAACAAAGCTATAAAAATTACA
GTACCAAAGCAGTCAGACTCACAGCCTAATTCTGATAACCTAAGTCGCCATGGTGAATGTGGGAAAAAGCAAGTGTCTTACAGAACTGAT
ATTGTTGGTGGCGTACCCATCATTACTCCCACTCAGAAAGAAGAAGTAAATGAATGTGGTGAAAGTATTGACAGAAATAATCTGAAACGG
TCACAAAGCCATCTTCCTTACTTTACTCCTAAACCACCTCAAGATAGTGCGGTTATCAAAGCTGGATATTGTGTAAAACAAGGAGCAGTG
ATGAAAAACTGGAAGAGAAGATATTTTCAATTGGATGAAAACACAATAGGCTACTTCAAATCTGAACTGGAAAAGGAACCTCTTCGTGTA
ATACCACTTAAAGAGGTTCATAAAGTCCAGGAATGTAAGCAAAGAATAAAGAAATAGAAGAACTCACCAAGATTTGTGACGAACTGATTG
CCAAAATGGGGAAAAGCTAACTCTGAACCGAATGTTTTGGACTTAACTGTTGCGTGCAATATGACCGTCGGCACACTGCTGTTCCTCCAG
TTCCATGGACAGGTTCTGTTTTCACTTTTTCGTATGCACTACTGTATTTCCTTTCTAAATAAAATTGATTTGATTGTATGCAGTACTAAG
GAGACTATCAGAATTTCTTGCTATTGGTTTGCATTTTCCTAGTATAATTCATAGCAAGTTGACCTCAGAGTTCCTGTATCAGGGAGATTG
TCTGATTCTCTAATAAAAGACACATTGCTGACCTTGGCCTTGCCCTTTGTACACAAGTTCCCAGGGTGAGCAGCTTTTGGATTTAATATG
AACATGTACAGCGTGCATAGGGACTCTTGCCTTAAGGAGTGTAAACTTGATCTGCATTTGCTGATTTGTTTTTAAAAAAACAAGAAATGC

>66156_66156_8_PLEKHA1-TACC2_PLEKHA1_chr10_124183779_ENST00000368989_TACC2_chr10_124013506_ENST00000358010_length(amino acids)=252AA_BP=
MPYVDRQNRICGFLDIEENENSGKFLRRYFILDTREDSFVWYMDNPQNLPSGSSRVGAIKLTYISKVSDATKLRPKAEFCFVMNAGMRKY
FLQANDQQDLVEWVNVLNKAIKITVPKQSDSQPNSDNLSRHGECGKKQVSYRTDIVGGVPIITPTQKEEVNECGESIDRNNLKRSQSHLP

--------------------------------------------------------------
>66156_66156_9_PLEKHA1-TACC2_PLEKHA1_chr10_124183779_ENST00000368989_TACC2_chr10_124013506_ENST00000368999_length(transcript)=1347nt_BP=854nt
TGGGAGCCGGGGCCGCGGCGGCGCGGGTGCTCCGGGCCGAGGCCGCGGTAAAGTTTAGCTTGAAGAACGCGGCCGCGCTGGAGCAGGGTG
TAATGTTCAAGCTCAGAAATGCCTTATGTGGATCGTCAGAATCGCATTTGTGGTTTTCTAGACATTGAAGAAAATGAAAACAGTGGGAAA
TTTCTTCGAAGGTACTTCATACTGGATACCAGAGAAGATAGTTTCGTGTGGTACATGGATAATCCACAGAACCTACCTTCTGGATCATCA
CGTGTTGGAGCCATTAAGCTTACCTACATTTCAAAGGTTAGCGATGCTACTAAGCTAAGGCCAAAGGCGGAGTTCTGTTTTGTTATGAAT
GCAGGAATGAGGAAGTACTTCCTACAAGCCAATGATCAGCAGGACCTAGTGGAATGGGTAAATGTGTTAAACAAAGCTATAAAAATTACA
GTACCAAAGCAGTCAGACTCACAGCCTAATTCTGATAACCTAAGTCGCCATGGTGAATGTGGGAAAAAGCAAGTGTCTTACAGAACTGAT
ATTGTTGGTGGCGTACCCATCATTACTCCCACTCAGAAAGAAGAAGTAAATGAATGTGGTGAAAGTATTGACAGAAATAATCTGAAACGG
TCACAAAGCCATCTTCCTTACTTTACTCCTAAACCACCTCAAGATAGTGCGGTTATCAAAGCTGGATATTGTGTAAAACAAGGAGCAGTG
ATGAAAAACTGGAAGAGAAGATATTTTCAATTGGATGAAAACACAATAGGCTACTTCAAATCTGAACTGGAAAAGGAACCTCTTCGTGTA
ATACCACTTAAAGAGGTTCATAAAGTCCAGGAATGTAAGCAAAGAATAAAGAAATAGAAGAACTCACCAAGATTTGTGACGAACTGATTG
CCAAAATGGGGAAAAGCTAACTCTGAACCGAATGTTTTGGACTTAACTGTTGCGTGCAATATGACCGTCGGCACACTGCTGTTCCTCCAG
TTCCATGGACAGGTTCTGTTTTCACTTTTTCGTATGCACTACTGTATTTCCTTTCTAAATAAAATTGATTTGATTGTATGCAGTACTAAG
GAGACTATCAGAATTTCTTGCTATTGGTTTGCATTTTCCTAGTATAATTCATAGCAAGTTGACCTCAGAGTTCCTGTATCAGGGAGATTG
TCTGATTCTCTAATAAAAGACACATTGCTGACCTTGGCCTTGCCCTTTGTACACAAGTTCCCAGGGTGAGCAGCTTTTGGATTTAATATG

>66156_66156_9_PLEKHA1-TACC2_PLEKHA1_chr10_124183779_ENST00000368989_TACC2_chr10_124013506_ENST00000368999_length(amino acids)=252AA_BP=
MPYVDRQNRICGFLDIEENENSGKFLRRYFILDTREDSFVWYMDNPQNLPSGSSRVGAIKLTYISKVSDATKLRPKAEFCFVMNAGMRKY
FLQANDQQDLVEWVNVLNKAIKITVPKQSDSQPNSDNLSRHGECGKKQVSYRTDIVGGVPIITPTQKEEVNECGESIDRNNLKRSQSHLP

--------------------------------------------------------------
>66156_66156_10_PLEKHA1-TACC2_PLEKHA1_chr10_124183779_ENST00000368989_TACC2_chr10_124013506_ENST00000453444_length(transcript)=1209nt_BP=854nt
TGGGAGCCGGGGCCGCGGCGGCGCGGGTGCTCCGGGCCGAGGCCGCGGTAAAGTTTAGCTTGAAGAACGCGGCCGCGCTGGAGCAGGGTG
TAATGTTCAAGCTCAGAAATGCCTTATGTGGATCGTCAGAATCGCATTTGTGGTTTTCTAGACATTGAAGAAAATGAAAACAGTGGGAAA
TTTCTTCGAAGGTACTTCATACTGGATACCAGAGAAGATAGTTTCGTGTGGTACATGGATAATCCACAGAACCTACCTTCTGGATCATCA
CGTGTTGGAGCCATTAAGCTTACCTACATTTCAAAGGTTAGCGATGCTACTAAGCTAAGGCCAAAGGCGGAGTTCTGTTTTGTTATGAAT
GCAGGAATGAGGAAGTACTTCCTACAAGCCAATGATCAGCAGGACCTAGTGGAATGGGTAAATGTGTTAAACAAAGCTATAAAAATTACA
GTACCAAAGCAGTCAGACTCACAGCCTAATTCTGATAACCTAAGTCGCCATGGTGAATGTGGGAAAAAGCAAGTGTCTTACAGAACTGAT
ATTGTTGGTGGCGTACCCATCATTACTCCCACTCAGAAAGAAGAAGTAAATGAATGTGGTGAAAGTATTGACAGAAATAATCTGAAACGG
TCACAAAGCCATCTTCCTTACTTTACTCCTAAACCACCTCAAGATAGTGCGGTTATCAAAGCTGGATATTGTGTAAAACAAGGAGCAGTG
ATGAAAAACTGGAAGAGAAGATATTTTCAATTGGATGAAAACACAATAGGCTACTTCAAATCTGAACTGGAAAAGGAACCTCTTCGTGTA
ATACCACTTAAAGAGGTTCATAAAGTCCAGGAATGTAAGCAAAGAATAAAGAAATAGAAGAACTCACCAAGATTTGTGACGAACTGATTG
CCAAAATGGGGAAAAGCTAACTCTGAACCGAATGTTTTGGACTTAACTGTTGCGTGCAATATGACCGTCGGCACACTGCTGTTCCTCCAG
TTCCATGGACAGGTTCTGTTTTCACTTTTTCGTATGCACTACTGTATTTCCTTTCTAAATAAAATTGATTTGATTGTATGCAGTACTAAG
GAGACTATCAGAATTTCTTGCTATTGGTTTGCATTTTCCTAGTATAATTCATAGCAAGTTGACCTCAGAGTTCCTGTATCAGGGAGATTG

>66156_66156_10_PLEKHA1-TACC2_PLEKHA1_chr10_124183779_ENST00000368989_TACC2_chr10_124013506_ENST00000453444_length(amino acids)=252AA_BP=
MPYVDRQNRICGFLDIEENENSGKFLRRYFILDTREDSFVWYMDNPQNLPSGSSRVGAIKLTYISKVSDATKLRPKAEFCFVMNAGMRKY
FLQANDQQDLVEWVNVLNKAIKITVPKQSDSQPNSDNLSRHGECGKKQVSYRTDIVGGVPIITPTQKEEVNECGESIDRNNLKRSQSHLP

--------------------------------------------------------------
>66156_66156_11_PLEKHA1-TACC2_PLEKHA1_chr10_124183779_ENST00000368989_TACC2_chr10_124013506_ENST00000515273_length(transcript)=1209nt_BP=854nt
TGGGAGCCGGGGCCGCGGCGGCGCGGGTGCTCCGGGCCGAGGCCGCGGTAAAGTTTAGCTTGAAGAACGCGGCCGCGCTGGAGCAGGGTG
TAATGTTCAAGCTCAGAAATGCCTTATGTGGATCGTCAGAATCGCATTTGTGGTTTTCTAGACATTGAAGAAAATGAAAACAGTGGGAAA
TTTCTTCGAAGGTACTTCATACTGGATACCAGAGAAGATAGTTTCGTGTGGTACATGGATAATCCACAGAACCTACCTTCTGGATCATCA
CGTGTTGGAGCCATTAAGCTTACCTACATTTCAAAGGTTAGCGATGCTACTAAGCTAAGGCCAAAGGCGGAGTTCTGTTTTGTTATGAAT
GCAGGAATGAGGAAGTACTTCCTACAAGCCAATGATCAGCAGGACCTAGTGGAATGGGTAAATGTGTTAAACAAAGCTATAAAAATTACA
GTACCAAAGCAGTCAGACTCACAGCCTAATTCTGATAACCTAAGTCGCCATGGTGAATGTGGGAAAAAGCAAGTGTCTTACAGAACTGAT
ATTGTTGGTGGCGTACCCATCATTACTCCCACTCAGAAAGAAGAAGTAAATGAATGTGGTGAAAGTATTGACAGAAATAATCTGAAACGG
TCACAAAGCCATCTTCCTTACTTTACTCCTAAACCACCTCAAGATAGTGCGGTTATCAAAGCTGGATATTGTGTAAAACAAGGAGCAGTG
ATGAAAAACTGGAAGAGAAGATATTTTCAATTGGATGAAAACACAATAGGCTACTTCAAATCTGAACTGGAAAAGGAACCTCTTCGTGTA
ATACCACTTAAAGAGGTTCATAAAGTCCAGGAATGTAAGCAAAGAATAAAGAAATAGAAGAACTCACCAAGATTTGTGACGAACTGATTG
CCAAAATGGGGAAAAGCTAACTCTGAACCGAATGTTTTGGACTTAACTGTTGCGTGCAATATGACCGTCGGCACACTGCTGTTCCTCCAG
TTCCATGGACAGGTTCTGTTTTCACTTTTTCGTATGCACTACTGTATTTCCTTTCTAAATAAAATTGATTTGATTGTATGCAGTACTAAG
GAGACTATCAGAATTTCTTGCTATTGGTTTGCATTTTCCTAGTATAATTCATAGCAAGTTGACCTCAGAGTTCCTGTATCAGGGAGATTG

>66156_66156_11_PLEKHA1-TACC2_PLEKHA1_chr10_124183779_ENST00000368989_TACC2_chr10_124013506_ENST00000515273_length(amino acids)=252AA_BP=
MPYVDRQNRICGFLDIEENENSGKFLRRYFILDTREDSFVWYMDNPQNLPSGSSRVGAIKLTYISKVSDATKLRPKAEFCFVMNAGMRKY
FLQANDQQDLVEWVNVLNKAIKITVPKQSDSQPNSDNLSRHGECGKKQVSYRTDIVGGVPIITPTQKEEVNECGESIDRNNLKRSQSHLP

--------------------------------------------------------------
>66156_66156_12_PLEKHA1-TACC2_PLEKHA1_chr10_124183779_ENST00000368989_TACC2_chr10_124013506_ENST00000515603_length(transcript)=1212nt_BP=854nt
TGGGAGCCGGGGCCGCGGCGGCGCGGGTGCTCCGGGCCGAGGCCGCGGTAAAGTTTAGCTTGAAGAACGCGGCCGCGCTGGAGCAGGGTG
TAATGTTCAAGCTCAGAAATGCCTTATGTGGATCGTCAGAATCGCATTTGTGGTTTTCTAGACATTGAAGAAAATGAAAACAGTGGGAAA
TTTCTTCGAAGGTACTTCATACTGGATACCAGAGAAGATAGTTTCGTGTGGTACATGGATAATCCACAGAACCTACCTTCTGGATCATCA
CGTGTTGGAGCCATTAAGCTTACCTACATTTCAAAGGTTAGCGATGCTACTAAGCTAAGGCCAAAGGCGGAGTTCTGTTTTGTTATGAAT
GCAGGAATGAGGAAGTACTTCCTACAAGCCAATGATCAGCAGGACCTAGTGGAATGGGTAAATGTGTTAAACAAAGCTATAAAAATTACA
GTACCAAAGCAGTCAGACTCACAGCCTAATTCTGATAACCTAAGTCGCCATGGTGAATGTGGGAAAAAGCAAGTGTCTTACAGAACTGAT
ATTGTTGGTGGCGTACCCATCATTACTCCCACTCAGAAAGAAGAAGTAAATGAATGTGGTGAAAGTATTGACAGAAATAATCTGAAACGG
TCACAAAGCCATCTTCCTTACTTTACTCCTAAACCACCTCAAGATAGTGCGGTTATCAAAGCTGGATATTGTGTAAAACAAGGAGCAGTG
ATGAAAAACTGGAAGAGAAGATATTTTCAATTGGATGAAAACACAATAGGCTACTTCAAATCTGAACTGGAAAAGGAACCTCTTCGTGTA
ATACCACTTAAAGAGGTTCATAAAGTCCAGGAATGTAAGCAAAGAATAAAGAAATAGAAGAACTCACCAAGATTTGTGACGAACTGATTG
CCAAAATGGGGAAAAGCTAACTCTGAACCGAATGTTTTGGACTTAACTGTTGCGTGCAATATGACCGTCGGCACACTGCTGTTCCTCCAG
TTCCATGGACAGGTTCTGTTTTCACTTTTTCGTATGCACTACTGTATTTCCTTTCTAAATAAAATTGATTTGATTGTATGCAGTACTAAG
GAGACTATCAGAATTTCTTGCTATTGGTTTGCATTTTCCTAGTATAATTCATAGCAAGTTGACCTCAGAGTTCCTGTATCAGGGAGATTG

>66156_66156_12_PLEKHA1-TACC2_PLEKHA1_chr10_124183779_ENST00000368989_TACC2_chr10_124013506_ENST00000515603_length(amino acids)=252AA_BP=
MPYVDRQNRICGFLDIEENENSGKFLRRYFILDTREDSFVWYMDNPQNLPSGSSRVGAIKLTYISKVSDATKLRPKAEFCFVMNAGMRKY
FLQANDQQDLVEWVNVLNKAIKITVPKQSDSQPNSDNLSRHGECGKKQVSYRTDIVGGVPIITPTQKEEVNECGESIDRNNLKRSQSHLP

--------------------------------------------------------------
>66156_66156_13_PLEKHA1-TACC2_PLEKHA1_chr10_124183779_ENST00000368990_TACC2_chr10_124013506_ENST00000334433_length(transcript)=1427nt_BP=877nt
GGGGACGCGTGCGCAGTGCGCGGGCTGGCCGTCGCGGACGCCGCTCCGGGCAGCCGAGCCTCTGTGGGAGCCGGGGCCGCGGCGGCGCGG
GTGCTCCGGGCCGAGGCCGCGTGTAATGTTCAAGCTCAGAAATGCCTTATGTGGATCGTCAGAATCGCATTTGTGGTTTTCTAGACATTG
AAGAAAATGAAAACAGTGGGAAATTTCTTCGAAGGTACTTCATACTGGATACCAGAGAAGATAGTTTCGTGTGGTACATGGATAATCCAC
AGAACCTACCTTCTGGATCATCACGTGTTGGAGCCATTAAGCTTACCTACATTTCAAAGGTTAGCGATGCTACTAAGCTAAGGCCAAAGG
CGGAGTTCTGTTTTGTTATGAATGCAGGAATGAGGAAGTACTTCCTACAAGCCAATGATCAGCAGGACCTAGTGGAATGGGTAAATGTGT
TAAACAAAGCTATAAAAATTACAGTACCAAAGCAGTCAGACTCACAGCCTAATTCTGATAACCTAAGTCGCCATGGTGAATGTGGGAAAA
AGCAAGTGTCTTACAGAACTGATATTGTTGGTGGCGTACCCATCATTACTCCCACTCAGAAAGAAGAAGTAAATGAATGTGGTGAAAGTA
TTGACAGAAATAATCTGAAACGGTCACAAAGCCATCTTCCTTACTTTACTCCTAAACCACCTCAAGATAGTGCGGTTATCAAAGCTGGAT
ATTGTGTAAAACAAGGAGCAGTGATGAAAAACTGGAAGAGAAGATATTTTCAATTGGATGAAAACACAATAGGCTACTTCAAATCTGAAC
TGGAAAAGGAACCTCTTCGTGTAATACCACTTAAAGAGGTTCATAAAGTCCAGGAATGTAAGCAAAGAATAAAGAAATAGAAGAACTCAC
CAAGATTTGTGACGAACTGATTGCCAAAATGGGGAAAAGCTAACTCTGAACCGAATGTTTTGGACTTAACTGTTGCGTGCAATATGACCG
TCGGCACACTGCTGTTCCTCCAGTTCCATGGACAGGTTCTGTTTTCACTTTTTCGTATGCACTACTGTATTTCCTTTCTAAATAAAATTG
ATTTGATTGTATGCAGTACTAAGGAGACTATCAGAATTTCTTGCTATTGGTTTGCATTTTCCTAGTATAATTCATAGCAAGTTGACCTCA
GAGTTCCTGTATCAGGGAGATTGTCTGATTCTCTAATAAAAGACACATTGCTGACCTTGGCCTTGCCCTTTGTACACAAGTTCCCAGGGT
GAGCAGCTTTTGGATTTAATATGAACATGTACAGCGTGCATAGGGACTCTTGCCTTAAGGAGTGTAAACTTGATCTGCATTTGCTGATTT

>66156_66156_13_PLEKHA1-TACC2_PLEKHA1_chr10_124183779_ENST00000368990_TACC2_chr10_124013506_ENST00000334433_length(amino acids)=252AA_BP=
MPYVDRQNRICGFLDIEENENSGKFLRRYFILDTREDSFVWYMDNPQNLPSGSSRVGAIKLTYISKVSDATKLRPKAEFCFVMNAGMRKY
FLQANDQQDLVEWVNVLNKAIKITVPKQSDSQPNSDNLSRHGECGKKQVSYRTDIVGGVPIITPTQKEEVNECGESIDRNNLKRSQSHLP

--------------------------------------------------------------
>66156_66156_14_PLEKHA1-TACC2_PLEKHA1_chr10_124183779_ENST00000368990_TACC2_chr10_124013506_ENST00000358010_length(transcript)=1427nt_BP=877nt
GGGGACGCGTGCGCAGTGCGCGGGCTGGCCGTCGCGGACGCCGCTCCGGGCAGCCGAGCCTCTGTGGGAGCCGGGGCCGCGGCGGCGCGG
GTGCTCCGGGCCGAGGCCGCGTGTAATGTTCAAGCTCAGAAATGCCTTATGTGGATCGTCAGAATCGCATTTGTGGTTTTCTAGACATTG
AAGAAAATGAAAACAGTGGGAAATTTCTTCGAAGGTACTTCATACTGGATACCAGAGAAGATAGTTTCGTGTGGTACATGGATAATCCAC
AGAACCTACCTTCTGGATCATCACGTGTTGGAGCCATTAAGCTTACCTACATTTCAAAGGTTAGCGATGCTACTAAGCTAAGGCCAAAGG
CGGAGTTCTGTTTTGTTATGAATGCAGGAATGAGGAAGTACTTCCTACAAGCCAATGATCAGCAGGACCTAGTGGAATGGGTAAATGTGT
TAAACAAAGCTATAAAAATTACAGTACCAAAGCAGTCAGACTCACAGCCTAATTCTGATAACCTAAGTCGCCATGGTGAATGTGGGAAAA
AGCAAGTGTCTTACAGAACTGATATTGTTGGTGGCGTACCCATCATTACTCCCACTCAGAAAGAAGAAGTAAATGAATGTGGTGAAAGTA
TTGACAGAAATAATCTGAAACGGTCACAAAGCCATCTTCCTTACTTTACTCCTAAACCACCTCAAGATAGTGCGGTTATCAAAGCTGGAT
ATTGTGTAAAACAAGGAGCAGTGATGAAAAACTGGAAGAGAAGATATTTTCAATTGGATGAAAACACAATAGGCTACTTCAAATCTGAAC
TGGAAAAGGAACCTCTTCGTGTAATACCACTTAAAGAGGTTCATAAAGTCCAGGAATGTAAGCAAAGAATAAAGAAATAGAAGAACTCAC
CAAGATTTGTGACGAACTGATTGCCAAAATGGGGAAAAGCTAACTCTGAACCGAATGTTTTGGACTTAACTGTTGCGTGCAATATGACCG
TCGGCACACTGCTGTTCCTCCAGTTCCATGGACAGGTTCTGTTTTCACTTTTTCGTATGCACTACTGTATTTCCTTTCTAAATAAAATTG
ATTTGATTGTATGCAGTACTAAGGAGACTATCAGAATTTCTTGCTATTGGTTTGCATTTTCCTAGTATAATTCATAGCAAGTTGACCTCA
GAGTTCCTGTATCAGGGAGATTGTCTGATTCTCTAATAAAAGACACATTGCTGACCTTGGCCTTGCCCTTTGTACACAAGTTCCCAGGGT
GAGCAGCTTTTGGATTTAATATGAACATGTACAGCGTGCATAGGGACTCTTGCCTTAAGGAGTGTAAACTTGATCTGCATTTGCTGATTT

>66156_66156_14_PLEKHA1-TACC2_PLEKHA1_chr10_124183779_ENST00000368990_TACC2_chr10_124013506_ENST00000358010_length(amino acids)=252AA_BP=
MPYVDRQNRICGFLDIEENENSGKFLRRYFILDTREDSFVWYMDNPQNLPSGSSRVGAIKLTYISKVSDATKLRPKAEFCFVMNAGMRKY
FLQANDQQDLVEWVNVLNKAIKITVPKQSDSQPNSDNLSRHGECGKKQVSYRTDIVGGVPIITPTQKEEVNECGESIDRNNLKRSQSHLP

--------------------------------------------------------------
>66156_66156_15_PLEKHA1-TACC2_PLEKHA1_chr10_124183779_ENST00000368990_TACC2_chr10_124013506_ENST00000368999_length(transcript)=1370nt_BP=877nt
GGGGACGCGTGCGCAGTGCGCGGGCTGGCCGTCGCGGACGCCGCTCCGGGCAGCCGAGCCTCTGTGGGAGCCGGGGCCGCGGCGGCGCGG
GTGCTCCGGGCCGAGGCCGCGTGTAATGTTCAAGCTCAGAAATGCCTTATGTGGATCGTCAGAATCGCATTTGTGGTTTTCTAGACATTG
AAGAAAATGAAAACAGTGGGAAATTTCTTCGAAGGTACTTCATACTGGATACCAGAGAAGATAGTTTCGTGTGGTACATGGATAATCCAC
AGAACCTACCTTCTGGATCATCACGTGTTGGAGCCATTAAGCTTACCTACATTTCAAAGGTTAGCGATGCTACTAAGCTAAGGCCAAAGG
CGGAGTTCTGTTTTGTTATGAATGCAGGAATGAGGAAGTACTTCCTACAAGCCAATGATCAGCAGGACCTAGTGGAATGGGTAAATGTGT
TAAACAAAGCTATAAAAATTACAGTACCAAAGCAGTCAGACTCACAGCCTAATTCTGATAACCTAAGTCGCCATGGTGAATGTGGGAAAA
AGCAAGTGTCTTACAGAACTGATATTGTTGGTGGCGTACCCATCATTACTCCCACTCAGAAAGAAGAAGTAAATGAATGTGGTGAAAGTA
TTGACAGAAATAATCTGAAACGGTCACAAAGCCATCTTCCTTACTTTACTCCTAAACCACCTCAAGATAGTGCGGTTATCAAAGCTGGAT
ATTGTGTAAAACAAGGAGCAGTGATGAAAAACTGGAAGAGAAGATATTTTCAATTGGATGAAAACACAATAGGCTACTTCAAATCTGAAC
TGGAAAAGGAACCTCTTCGTGTAATACCACTTAAAGAGGTTCATAAAGTCCAGGAATGTAAGCAAAGAATAAAGAAATAGAAGAACTCAC
CAAGATTTGTGACGAACTGATTGCCAAAATGGGGAAAAGCTAACTCTGAACCGAATGTTTTGGACTTAACTGTTGCGTGCAATATGACCG
TCGGCACACTGCTGTTCCTCCAGTTCCATGGACAGGTTCTGTTTTCACTTTTTCGTATGCACTACTGTATTTCCTTTCTAAATAAAATTG
ATTTGATTGTATGCAGTACTAAGGAGACTATCAGAATTTCTTGCTATTGGTTTGCATTTTCCTAGTATAATTCATAGCAAGTTGACCTCA
GAGTTCCTGTATCAGGGAGATTGTCTGATTCTCTAATAAAAGACACATTGCTGACCTTGGCCTTGCCCTTTGTACACAAGTTCCCAGGGT
GAGCAGCTTTTGGATTTAATATGAACATGTACAGCGTGCATAGGGACTCTTGCCTTAAGGAGTGTAAACTTGATCTGCATTTGCTGATTT

>66156_66156_15_PLEKHA1-TACC2_PLEKHA1_chr10_124183779_ENST00000368990_TACC2_chr10_124013506_ENST00000368999_length(amino acids)=252AA_BP=
MPYVDRQNRICGFLDIEENENSGKFLRRYFILDTREDSFVWYMDNPQNLPSGSSRVGAIKLTYISKVSDATKLRPKAEFCFVMNAGMRKY
FLQANDQQDLVEWVNVLNKAIKITVPKQSDSQPNSDNLSRHGECGKKQVSYRTDIVGGVPIITPTQKEEVNECGESIDRNNLKRSQSHLP

--------------------------------------------------------------
>66156_66156_16_PLEKHA1-TACC2_PLEKHA1_chr10_124183779_ENST00000368990_TACC2_chr10_124013506_ENST00000453444_length(transcript)=1232nt_BP=877nt
GGGGACGCGTGCGCAGTGCGCGGGCTGGCCGTCGCGGACGCCGCTCCGGGCAGCCGAGCCTCTGTGGGAGCCGGGGCCGCGGCGGCGCGG
GTGCTCCGGGCCGAGGCCGCGTGTAATGTTCAAGCTCAGAAATGCCTTATGTGGATCGTCAGAATCGCATTTGTGGTTTTCTAGACATTG
AAGAAAATGAAAACAGTGGGAAATTTCTTCGAAGGTACTTCATACTGGATACCAGAGAAGATAGTTTCGTGTGGTACATGGATAATCCAC
AGAACCTACCTTCTGGATCATCACGTGTTGGAGCCATTAAGCTTACCTACATTTCAAAGGTTAGCGATGCTACTAAGCTAAGGCCAAAGG
CGGAGTTCTGTTTTGTTATGAATGCAGGAATGAGGAAGTACTTCCTACAAGCCAATGATCAGCAGGACCTAGTGGAATGGGTAAATGTGT
TAAACAAAGCTATAAAAATTACAGTACCAAAGCAGTCAGACTCACAGCCTAATTCTGATAACCTAAGTCGCCATGGTGAATGTGGGAAAA
AGCAAGTGTCTTACAGAACTGATATTGTTGGTGGCGTACCCATCATTACTCCCACTCAGAAAGAAGAAGTAAATGAATGTGGTGAAAGTA
TTGACAGAAATAATCTGAAACGGTCACAAAGCCATCTTCCTTACTTTACTCCTAAACCACCTCAAGATAGTGCGGTTATCAAAGCTGGAT
ATTGTGTAAAACAAGGAGCAGTGATGAAAAACTGGAAGAGAAGATATTTTCAATTGGATGAAAACACAATAGGCTACTTCAAATCTGAAC
TGGAAAAGGAACCTCTTCGTGTAATACCACTTAAAGAGGTTCATAAAGTCCAGGAATGTAAGCAAAGAATAAAGAAATAGAAGAACTCAC
CAAGATTTGTGACGAACTGATTGCCAAAATGGGGAAAAGCTAACTCTGAACCGAATGTTTTGGACTTAACTGTTGCGTGCAATATGACCG
TCGGCACACTGCTGTTCCTCCAGTTCCATGGACAGGTTCTGTTTTCACTTTTTCGTATGCACTACTGTATTTCCTTTCTAAATAAAATTG
ATTTGATTGTATGCAGTACTAAGGAGACTATCAGAATTTCTTGCTATTGGTTTGCATTTTCCTAGTATAATTCATAGCAAGTTGACCTCA

>66156_66156_16_PLEKHA1-TACC2_PLEKHA1_chr10_124183779_ENST00000368990_TACC2_chr10_124013506_ENST00000453444_length(amino acids)=252AA_BP=
MPYVDRQNRICGFLDIEENENSGKFLRRYFILDTREDSFVWYMDNPQNLPSGSSRVGAIKLTYISKVSDATKLRPKAEFCFVMNAGMRKY
FLQANDQQDLVEWVNVLNKAIKITVPKQSDSQPNSDNLSRHGECGKKQVSYRTDIVGGVPIITPTQKEEVNECGESIDRNNLKRSQSHLP

--------------------------------------------------------------
>66156_66156_17_PLEKHA1-TACC2_PLEKHA1_chr10_124183779_ENST00000368990_TACC2_chr10_124013506_ENST00000515273_length(transcript)=1232nt_BP=877nt
GGGGACGCGTGCGCAGTGCGCGGGCTGGCCGTCGCGGACGCCGCTCCGGGCAGCCGAGCCTCTGTGGGAGCCGGGGCCGCGGCGGCGCGG
GTGCTCCGGGCCGAGGCCGCGTGTAATGTTCAAGCTCAGAAATGCCTTATGTGGATCGTCAGAATCGCATTTGTGGTTTTCTAGACATTG
AAGAAAATGAAAACAGTGGGAAATTTCTTCGAAGGTACTTCATACTGGATACCAGAGAAGATAGTTTCGTGTGGTACATGGATAATCCAC
AGAACCTACCTTCTGGATCATCACGTGTTGGAGCCATTAAGCTTACCTACATTTCAAAGGTTAGCGATGCTACTAAGCTAAGGCCAAAGG
CGGAGTTCTGTTTTGTTATGAATGCAGGAATGAGGAAGTACTTCCTACAAGCCAATGATCAGCAGGACCTAGTGGAATGGGTAAATGTGT
TAAACAAAGCTATAAAAATTACAGTACCAAAGCAGTCAGACTCACAGCCTAATTCTGATAACCTAAGTCGCCATGGTGAATGTGGGAAAA
AGCAAGTGTCTTACAGAACTGATATTGTTGGTGGCGTACCCATCATTACTCCCACTCAGAAAGAAGAAGTAAATGAATGTGGTGAAAGTA
TTGACAGAAATAATCTGAAACGGTCACAAAGCCATCTTCCTTACTTTACTCCTAAACCACCTCAAGATAGTGCGGTTATCAAAGCTGGAT
ATTGTGTAAAACAAGGAGCAGTGATGAAAAACTGGAAGAGAAGATATTTTCAATTGGATGAAAACACAATAGGCTACTTCAAATCTGAAC
TGGAAAAGGAACCTCTTCGTGTAATACCACTTAAAGAGGTTCATAAAGTCCAGGAATGTAAGCAAAGAATAAAGAAATAGAAGAACTCAC
CAAGATTTGTGACGAACTGATTGCCAAAATGGGGAAAAGCTAACTCTGAACCGAATGTTTTGGACTTAACTGTTGCGTGCAATATGACCG
TCGGCACACTGCTGTTCCTCCAGTTCCATGGACAGGTTCTGTTTTCACTTTTTCGTATGCACTACTGTATTTCCTTTCTAAATAAAATTG
ATTTGATTGTATGCAGTACTAAGGAGACTATCAGAATTTCTTGCTATTGGTTTGCATTTTCCTAGTATAATTCATAGCAAGTTGACCTCA

>66156_66156_17_PLEKHA1-TACC2_PLEKHA1_chr10_124183779_ENST00000368990_TACC2_chr10_124013506_ENST00000515273_length(amino acids)=252AA_BP=
MPYVDRQNRICGFLDIEENENSGKFLRRYFILDTREDSFVWYMDNPQNLPSGSSRVGAIKLTYISKVSDATKLRPKAEFCFVMNAGMRKY
FLQANDQQDLVEWVNVLNKAIKITVPKQSDSQPNSDNLSRHGECGKKQVSYRTDIVGGVPIITPTQKEEVNECGESIDRNNLKRSQSHLP

--------------------------------------------------------------
>66156_66156_18_PLEKHA1-TACC2_PLEKHA1_chr10_124183779_ENST00000368990_TACC2_chr10_124013506_ENST00000515603_length(transcript)=1235nt_BP=877nt
GGGGACGCGTGCGCAGTGCGCGGGCTGGCCGTCGCGGACGCCGCTCCGGGCAGCCGAGCCTCTGTGGGAGCCGGGGCCGCGGCGGCGCGG
GTGCTCCGGGCCGAGGCCGCGTGTAATGTTCAAGCTCAGAAATGCCTTATGTGGATCGTCAGAATCGCATTTGTGGTTTTCTAGACATTG
AAGAAAATGAAAACAGTGGGAAATTTCTTCGAAGGTACTTCATACTGGATACCAGAGAAGATAGTTTCGTGTGGTACATGGATAATCCAC
AGAACCTACCTTCTGGATCATCACGTGTTGGAGCCATTAAGCTTACCTACATTTCAAAGGTTAGCGATGCTACTAAGCTAAGGCCAAAGG
CGGAGTTCTGTTTTGTTATGAATGCAGGAATGAGGAAGTACTTCCTACAAGCCAATGATCAGCAGGACCTAGTGGAATGGGTAAATGTGT
TAAACAAAGCTATAAAAATTACAGTACCAAAGCAGTCAGACTCACAGCCTAATTCTGATAACCTAAGTCGCCATGGTGAATGTGGGAAAA
AGCAAGTGTCTTACAGAACTGATATTGTTGGTGGCGTACCCATCATTACTCCCACTCAGAAAGAAGAAGTAAATGAATGTGGTGAAAGTA
TTGACAGAAATAATCTGAAACGGTCACAAAGCCATCTTCCTTACTTTACTCCTAAACCACCTCAAGATAGTGCGGTTATCAAAGCTGGAT
ATTGTGTAAAACAAGGAGCAGTGATGAAAAACTGGAAGAGAAGATATTTTCAATTGGATGAAAACACAATAGGCTACTTCAAATCTGAAC
TGGAAAAGGAACCTCTTCGTGTAATACCACTTAAAGAGGTTCATAAAGTCCAGGAATGTAAGCAAAGAATAAAGAAATAGAAGAACTCAC
CAAGATTTGTGACGAACTGATTGCCAAAATGGGGAAAAGCTAACTCTGAACCGAATGTTTTGGACTTAACTGTTGCGTGCAATATGACCG
TCGGCACACTGCTGTTCCTCCAGTTCCATGGACAGGTTCTGTTTTCACTTTTTCGTATGCACTACTGTATTTCCTTTCTAAATAAAATTG
ATTTGATTGTATGCAGTACTAAGGAGACTATCAGAATTTCTTGCTATTGGTTTGCATTTTCCTAGTATAATTCATAGCAAGTTGACCTCA

>66156_66156_18_PLEKHA1-TACC2_PLEKHA1_chr10_124183779_ENST00000368990_TACC2_chr10_124013506_ENST00000515603_length(amino acids)=252AA_BP=
MPYVDRQNRICGFLDIEENENSGKFLRRYFILDTREDSFVWYMDNPQNLPSGSSRVGAIKLTYISKVSDATKLRPKAEFCFVMNAGMRKY
FLQANDQQDLVEWVNVLNKAIKITVPKQSDSQPNSDNLSRHGECGKKQVSYRTDIVGGVPIITPTQKEEVNECGESIDRNNLKRSQSHLP

--------------------------------------------------------------
>66156_66156_19_PLEKHA1-TACC2_PLEKHA1_chr10_124183779_ENST00000433307_TACC2_chr10_124013506_ENST00000334433_length(transcript)=1318nt_BP=768nt
AGTGTAATGTTCAAGCTCAGAAATGCCTTATGTGGATCGTCAGAATCGCATTTGTGGTTTTCTAGACATTGAAGAAAATGAAAACAGTGG
GAAATTTCTTCGAAGGTACTTCATACTGGATACCAGAGAAGATAGTTTCGTGTGGTACATGGATAATCCACAGAACCTACCTTCTGGATC
ATCACGTGTTGGAGCCATTAAGCTTACCTACATTTCAAAGGTTAGCGATGCTACTAAGCTAAGGCCAAAGGCGGAGTTCTGTTTTGTTAT
GAATGCAGGAATGAGGAAGTACTTCCTACAAGCCAATGATCAGCAGGACCTAGTGGAATGGGTAAATGTGTTAAACAAAGCTATAAAAAT
TACAGTACCAAAGCAGTCAGACTCACAGCCTAATTCTGATAACCTAAGTCGCCATGGTGAATGTGGGAAAAAGCAAGTGTCTTACAGAAC
TGATATTGTTGGTGGCGTACCCATCATTACTCCCACTCAGAAAGAAGAAGTAAATGAATGTGGTGAAAGTATTGACAGAAATAATCTGAA
ACGGTCACAAAGCCATCTTCCTTACTTTACTCCTAAACCACCTCAAGATAGTGCGGTTATCAAAGCTGGATATTGTGTAAAACAAGGAGC
AGTGATGAAAAACTGGAAGAGAAGATATTTTCAATTGGATGAAAACACAATAGGCTACTTCAAATCTGAACTGGAAAAGGAACCTCTTCG
TGTAATACCACTTAAAGAGGTTCATAAAGTCCAGGAATGTAAGCAAAGAATAAAGAAATAGAAGAACTCACCAAGATTTGTGACGAACTG
ATTGCCAAAATGGGGAAAAGCTAACTCTGAACCGAATGTTTTGGACTTAACTGTTGCGTGCAATATGACCGTCGGCACACTGCTGTTCCT
CCAGTTCCATGGACAGGTTCTGTTTTCACTTTTTCGTATGCACTACTGTATTTCCTTTCTAAATAAAATTGATTTGATTGTATGCAGTAC
TAAGGAGACTATCAGAATTTCTTGCTATTGGTTTGCATTTTCCTAGTATAATTCATAGCAAGTTGACCTCAGAGTTCCTGTATCAGGGAG
ATTGTCTGATTCTCTAATAAAAGACACATTGCTGACCTTGGCCTTGCCCTTTGTACACAAGTTCCCAGGGTGAGCAGCTTTTGGATTTAA
TATGAACATGTACAGCGTGCATAGGGACTCTTGCCTTAAGGAGTGTAAACTTGATCTGCATTTGCTGATTTGTTTTTAAAAAAACAAGAA

>66156_66156_19_PLEKHA1-TACC2_PLEKHA1_chr10_124183779_ENST00000433307_TACC2_chr10_124013506_ENST00000334433_length(amino acids)=252AA_BP=
MPYVDRQNRICGFLDIEENENSGKFLRRYFILDTREDSFVWYMDNPQNLPSGSSRVGAIKLTYISKVSDATKLRPKAEFCFVMNAGMRKY
FLQANDQQDLVEWVNVLNKAIKITVPKQSDSQPNSDNLSRHGECGKKQVSYRTDIVGGVPIITPTQKEEVNECGESIDRNNLKRSQSHLP

--------------------------------------------------------------
>66156_66156_20_PLEKHA1-TACC2_PLEKHA1_chr10_124183779_ENST00000433307_TACC2_chr10_124013506_ENST00000358010_length(transcript)=1318nt_BP=768nt
AGTGTAATGTTCAAGCTCAGAAATGCCTTATGTGGATCGTCAGAATCGCATTTGTGGTTTTCTAGACATTGAAGAAAATGAAAACAGTGG
GAAATTTCTTCGAAGGTACTTCATACTGGATACCAGAGAAGATAGTTTCGTGTGGTACATGGATAATCCACAGAACCTACCTTCTGGATC
ATCACGTGTTGGAGCCATTAAGCTTACCTACATTTCAAAGGTTAGCGATGCTACTAAGCTAAGGCCAAAGGCGGAGTTCTGTTTTGTTAT
GAATGCAGGAATGAGGAAGTACTTCCTACAAGCCAATGATCAGCAGGACCTAGTGGAATGGGTAAATGTGTTAAACAAAGCTATAAAAAT
TACAGTACCAAAGCAGTCAGACTCACAGCCTAATTCTGATAACCTAAGTCGCCATGGTGAATGTGGGAAAAAGCAAGTGTCTTACAGAAC
TGATATTGTTGGTGGCGTACCCATCATTACTCCCACTCAGAAAGAAGAAGTAAATGAATGTGGTGAAAGTATTGACAGAAATAATCTGAA
ACGGTCACAAAGCCATCTTCCTTACTTTACTCCTAAACCACCTCAAGATAGTGCGGTTATCAAAGCTGGATATTGTGTAAAACAAGGAGC
AGTGATGAAAAACTGGAAGAGAAGATATTTTCAATTGGATGAAAACACAATAGGCTACTTCAAATCTGAACTGGAAAAGGAACCTCTTCG
TGTAATACCACTTAAAGAGGTTCATAAAGTCCAGGAATGTAAGCAAAGAATAAAGAAATAGAAGAACTCACCAAGATTTGTGACGAACTG
ATTGCCAAAATGGGGAAAAGCTAACTCTGAACCGAATGTTTTGGACTTAACTGTTGCGTGCAATATGACCGTCGGCACACTGCTGTTCCT
CCAGTTCCATGGACAGGTTCTGTTTTCACTTTTTCGTATGCACTACTGTATTTCCTTTCTAAATAAAATTGATTTGATTGTATGCAGTAC
TAAGGAGACTATCAGAATTTCTTGCTATTGGTTTGCATTTTCCTAGTATAATTCATAGCAAGTTGACCTCAGAGTTCCTGTATCAGGGAG
ATTGTCTGATTCTCTAATAAAAGACACATTGCTGACCTTGGCCTTGCCCTTTGTACACAAGTTCCCAGGGTGAGCAGCTTTTGGATTTAA
TATGAACATGTACAGCGTGCATAGGGACTCTTGCCTTAAGGAGTGTAAACTTGATCTGCATTTGCTGATTTGTTTTTAAAAAAACAAGAA

>66156_66156_20_PLEKHA1-TACC2_PLEKHA1_chr10_124183779_ENST00000433307_TACC2_chr10_124013506_ENST00000358010_length(amino acids)=252AA_BP=
MPYVDRQNRICGFLDIEENENSGKFLRRYFILDTREDSFVWYMDNPQNLPSGSSRVGAIKLTYISKVSDATKLRPKAEFCFVMNAGMRKY
FLQANDQQDLVEWVNVLNKAIKITVPKQSDSQPNSDNLSRHGECGKKQVSYRTDIVGGVPIITPTQKEEVNECGESIDRNNLKRSQSHLP

--------------------------------------------------------------
>66156_66156_21_PLEKHA1-TACC2_PLEKHA1_chr10_124183779_ENST00000433307_TACC2_chr10_124013506_ENST00000368999_length(transcript)=1261nt_BP=768nt
AGTGTAATGTTCAAGCTCAGAAATGCCTTATGTGGATCGTCAGAATCGCATTTGTGGTTTTCTAGACATTGAAGAAAATGAAAACAGTGG
GAAATTTCTTCGAAGGTACTTCATACTGGATACCAGAGAAGATAGTTTCGTGTGGTACATGGATAATCCACAGAACCTACCTTCTGGATC
ATCACGTGTTGGAGCCATTAAGCTTACCTACATTTCAAAGGTTAGCGATGCTACTAAGCTAAGGCCAAAGGCGGAGTTCTGTTTTGTTAT
GAATGCAGGAATGAGGAAGTACTTCCTACAAGCCAATGATCAGCAGGACCTAGTGGAATGGGTAAATGTGTTAAACAAAGCTATAAAAAT
TACAGTACCAAAGCAGTCAGACTCACAGCCTAATTCTGATAACCTAAGTCGCCATGGTGAATGTGGGAAAAAGCAAGTGTCTTACAGAAC
TGATATTGTTGGTGGCGTACCCATCATTACTCCCACTCAGAAAGAAGAAGTAAATGAATGTGGTGAAAGTATTGACAGAAATAATCTGAA
ACGGTCACAAAGCCATCTTCCTTACTTTACTCCTAAACCACCTCAAGATAGTGCGGTTATCAAAGCTGGATATTGTGTAAAACAAGGAGC
AGTGATGAAAAACTGGAAGAGAAGATATTTTCAATTGGATGAAAACACAATAGGCTACTTCAAATCTGAACTGGAAAAGGAACCTCTTCG
TGTAATACCACTTAAAGAGGTTCATAAAGTCCAGGAATGTAAGCAAAGAATAAAGAAATAGAAGAACTCACCAAGATTTGTGACGAACTG
ATTGCCAAAATGGGGAAAAGCTAACTCTGAACCGAATGTTTTGGACTTAACTGTTGCGTGCAATATGACCGTCGGCACACTGCTGTTCCT
CCAGTTCCATGGACAGGTTCTGTTTTCACTTTTTCGTATGCACTACTGTATTTCCTTTCTAAATAAAATTGATTTGATTGTATGCAGTAC
TAAGGAGACTATCAGAATTTCTTGCTATTGGTTTGCATTTTCCTAGTATAATTCATAGCAAGTTGACCTCAGAGTTCCTGTATCAGGGAG
ATTGTCTGATTCTCTAATAAAAGACACATTGCTGACCTTGGCCTTGCCCTTTGTACACAAGTTCCCAGGGTGAGCAGCTTTTGGATTTAA
TATGAACATGTACAGCGTGCATAGGGACTCTTGCCTTAAGGAGTGTAAACTTGATCTGCATTTGCTGATTTGTTTTTAAAAAAACAAGAA

>66156_66156_21_PLEKHA1-TACC2_PLEKHA1_chr10_124183779_ENST00000433307_TACC2_chr10_124013506_ENST00000368999_length(amino acids)=252AA_BP=
MPYVDRQNRICGFLDIEENENSGKFLRRYFILDTREDSFVWYMDNPQNLPSGSSRVGAIKLTYISKVSDATKLRPKAEFCFVMNAGMRKY
FLQANDQQDLVEWVNVLNKAIKITVPKQSDSQPNSDNLSRHGECGKKQVSYRTDIVGGVPIITPTQKEEVNECGESIDRNNLKRSQSHLP

--------------------------------------------------------------
>66156_66156_22_PLEKHA1-TACC2_PLEKHA1_chr10_124183779_ENST00000433307_TACC2_chr10_124013506_ENST00000453444_length(transcript)=1123nt_BP=768nt
AGTGTAATGTTCAAGCTCAGAAATGCCTTATGTGGATCGTCAGAATCGCATTTGTGGTTTTCTAGACATTGAAGAAAATGAAAACAGTGG
GAAATTTCTTCGAAGGTACTTCATACTGGATACCAGAGAAGATAGTTTCGTGTGGTACATGGATAATCCACAGAACCTACCTTCTGGATC
ATCACGTGTTGGAGCCATTAAGCTTACCTACATTTCAAAGGTTAGCGATGCTACTAAGCTAAGGCCAAAGGCGGAGTTCTGTTTTGTTAT
GAATGCAGGAATGAGGAAGTACTTCCTACAAGCCAATGATCAGCAGGACCTAGTGGAATGGGTAAATGTGTTAAACAAAGCTATAAAAAT
TACAGTACCAAAGCAGTCAGACTCACAGCCTAATTCTGATAACCTAAGTCGCCATGGTGAATGTGGGAAAAAGCAAGTGTCTTACAGAAC
TGATATTGTTGGTGGCGTACCCATCATTACTCCCACTCAGAAAGAAGAAGTAAATGAATGTGGTGAAAGTATTGACAGAAATAATCTGAA
ACGGTCACAAAGCCATCTTCCTTACTTTACTCCTAAACCACCTCAAGATAGTGCGGTTATCAAAGCTGGATATTGTGTAAAACAAGGAGC
AGTGATGAAAAACTGGAAGAGAAGATATTTTCAATTGGATGAAAACACAATAGGCTACTTCAAATCTGAACTGGAAAAGGAACCTCTTCG
TGTAATACCACTTAAAGAGGTTCATAAAGTCCAGGAATGTAAGCAAAGAATAAAGAAATAGAAGAACTCACCAAGATTTGTGACGAACTG
ATTGCCAAAATGGGGAAAAGCTAACTCTGAACCGAATGTTTTGGACTTAACTGTTGCGTGCAATATGACCGTCGGCACACTGCTGTTCCT
CCAGTTCCATGGACAGGTTCTGTTTTCACTTTTTCGTATGCACTACTGTATTTCCTTTCTAAATAAAATTGATTTGATTGTATGCAGTAC
TAAGGAGACTATCAGAATTTCTTGCTATTGGTTTGCATTTTCCTAGTATAATTCATAGCAAGTTGACCTCAGAGTTCCTGTATCAGGGAG

>66156_66156_22_PLEKHA1-TACC2_PLEKHA1_chr10_124183779_ENST00000433307_TACC2_chr10_124013506_ENST00000453444_length(amino acids)=252AA_BP=
MPYVDRQNRICGFLDIEENENSGKFLRRYFILDTREDSFVWYMDNPQNLPSGSSRVGAIKLTYISKVSDATKLRPKAEFCFVMNAGMRKY
FLQANDQQDLVEWVNVLNKAIKITVPKQSDSQPNSDNLSRHGECGKKQVSYRTDIVGGVPIITPTQKEEVNECGESIDRNNLKRSQSHLP

--------------------------------------------------------------
>66156_66156_23_PLEKHA1-TACC2_PLEKHA1_chr10_124183779_ENST00000433307_TACC2_chr10_124013506_ENST00000515273_length(transcript)=1123nt_BP=768nt
AGTGTAATGTTCAAGCTCAGAAATGCCTTATGTGGATCGTCAGAATCGCATTTGTGGTTTTCTAGACATTGAAGAAAATGAAAACAGTGG
GAAATTTCTTCGAAGGTACTTCATACTGGATACCAGAGAAGATAGTTTCGTGTGGTACATGGATAATCCACAGAACCTACCTTCTGGATC
ATCACGTGTTGGAGCCATTAAGCTTACCTACATTTCAAAGGTTAGCGATGCTACTAAGCTAAGGCCAAAGGCGGAGTTCTGTTTTGTTAT
GAATGCAGGAATGAGGAAGTACTTCCTACAAGCCAATGATCAGCAGGACCTAGTGGAATGGGTAAATGTGTTAAACAAAGCTATAAAAAT
TACAGTACCAAAGCAGTCAGACTCACAGCCTAATTCTGATAACCTAAGTCGCCATGGTGAATGTGGGAAAAAGCAAGTGTCTTACAGAAC
TGATATTGTTGGTGGCGTACCCATCATTACTCCCACTCAGAAAGAAGAAGTAAATGAATGTGGTGAAAGTATTGACAGAAATAATCTGAA
ACGGTCACAAAGCCATCTTCCTTACTTTACTCCTAAACCACCTCAAGATAGTGCGGTTATCAAAGCTGGATATTGTGTAAAACAAGGAGC
AGTGATGAAAAACTGGAAGAGAAGATATTTTCAATTGGATGAAAACACAATAGGCTACTTCAAATCTGAACTGGAAAAGGAACCTCTTCG
TGTAATACCACTTAAAGAGGTTCATAAAGTCCAGGAATGTAAGCAAAGAATAAAGAAATAGAAGAACTCACCAAGATTTGTGACGAACTG
ATTGCCAAAATGGGGAAAAGCTAACTCTGAACCGAATGTTTTGGACTTAACTGTTGCGTGCAATATGACCGTCGGCACACTGCTGTTCCT
CCAGTTCCATGGACAGGTTCTGTTTTCACTTTTTCGTATGCACTACTGTATTTCCTTTCTAAATAAAATTGATTTGATTGTATGCAGTAC
TAAGGAGACTATCAGAATTTCTTGCTATTGGTTTGCATTTTCCTAGTATAATTCATAGCAAGTTGACCTCAGAGTTCCTGTATCAGGGAG

>66156_66156_23_PLEKHA1-TACC2_PLEKHA1_chr10_124183779_ENST00000433307_TACC2_chr10_124013506_ENST00000515273_length(amino acids)=252AA_BP=
MPYVDRQNRICGFLDIEENENSGKFLRRYFILDTREDSFVWYMDNPQNLPSGSSRVGAIKLTYISKVSDATKLRPKAEFCFVMNAGMRKY
FLQANDQQDLVEWVNVLNKAIKITVPKQSDSQPNSDNLSRHGECGKKQVSYRTDIVGGVPIITPTQKEEVNECGESIDRNNLKRSQSHLP

--------------------------------------------------------------
>66156_66156_24_PLEKHA1-TACC2_PLEKHA1_chr10_124183779_ENST00000433307_TACC2_chr10_124013506_ENST00000515603_length(transcript)=1126nt_BP=768nt
AGTGTAATGTTCAAGCTCAGAAATGCCTTATGTGGATCGTCAGAATCGCATTTGTGGTTTTCTAGACATTGAAGAAAATGAAAACAGTGG
GAAATTTCTTCGAAGGTACTTCATACTGGATACCAGAGAAGATAGTTTCGTGTGGTACATGGATAATCCACAGAACCTACCTTCTGGATC
ATCACGTGTTGGAGCCATTAAGCTTACCTACATTTCAAAGGTTAGCGATGCTACTAAGCTAAGGCCAAAGGCGGAGTTCTGTTTTGTTAT
GAATGCAGGAATGAGGAAGTACTTCCTACAAGCCAATGATCAGCAGGACCTAGTGGAATGGGTAAATGTGTTAAACAAAGCTATAAAAAT
TACAGTACCAAAGCAGTCAGACTCACAGCCTAATTCTGATAACCTAAGTCGCCATGGTGAATGTGGGAAAAAGCAAGTGTCTTACAGAAC
TGATATTGTTGGTGGCGTACCCATCATTACTCCCACTCAGAAAGAAGAAGTAAATGAATGTGGTGAAAGTATTGACAGAAATAATCTGAA
ACGGTCACAAAGCCATCTTCCTTACTTTACTCCTAAACCACCTCAAGATAGTGCGGTTATCAAAGCTGGATATTGTGTAAAACAAGGAGC
AGTGATGAAAAACTGGAAGAGAAGATATTTTCAATTGGATGAAAACACAATAGGCTACTTCAAATCTGAACTGGAAAAGGAACCTCTTCG
TGTAATACCACTTAAAGAGGTTCATAAAGTCCAGGAATGTAAGCAAAGAATAAAGAAATAGAAGAACTCACCAAGATTTGTGACGAACTG
ATTGCCAAAATGGGGAAAAGCTAACTCTGAACCGAATGTTTTGGACTTAACTGTTGCGTGCAATATGACCGTCGGCACACTGCTGTTCCT
CCAGTTCCATGGACAGGTTCTGTTTTCACTTTTTCGTATGCACTACTGTATTTCCTTTCTAAATAAAATTGATTTGATTGTATGCAGTAC
TAAGGAGACTATCAGAATTTCTTGCTATTGGTTTGCATTTTCCTAGTATAATTCATAGCAAGTTGACCTCAGAGTTCCTGTATCAGGGAG

>66156_66156_24_PLEKHA1-TACC2_PLEKHA1_chr10_124183779_ENST00000433307_TACC2_chr10_124013506_ENST00000515603_length(amino acids)=252AA_BP=
MPYVDRQNRICGFLDIEENENSGKFLRRYFILDTREDSFVWYMDNPQNLPSGSSRVGAIKLTYISKVSDATKLRPKAEFCFVMNAGMRKY
FLQANDQQDLVEWVNVLNKAIKITVPKQSDSQPNSDNLSRHGECGKKQVSYRTDIVGGVPIITPTQKEEVNECGESIDRNNLKRSQSHLP

--------------------------------------------------------------
>66156_66156_25_PLEKHA1-TACC2_PLEKHA1_chr10_124183779_ENST00000538022_TACC2_chr10_124013506_ENST00000334433_length(transcript)=1505nt_BP=955nt
AAAGTTGCTATGTCATTTTGCATTTCCACCAGCAATATATGATAGTTCGTTTATTTCACATCTTTGACAGCATTTAGTGTTGTCAGGGTT
TTTTTTGTTTGTTTTAGACATTTTAGTAGTCTGGCTCTTGCTGATTGAATTCCTTTGGTGCAGTTTAGCATGTTCCTCTGTGTTCTGCAT
CTCCTGTAGTGTAATGTTCAAGCTCAGAAATGCCTTATGTGGATCGTCAGAATCGCATTTGTGGTTTTCTAGACATTGAAGAAAATGAAA
ACAGTGGGAAATTTCTTCGAAGGTACTTCATACTGGATACCAGAGAAGATAGTTTCGTGTGGTACATGGATAATCCACAGAACCTACCTT
CTGGATCATCACGTGTTGGAGCCATTAAGCTTACCTACATTTCAAAGGTTAGCGATGCTACTAAGCTAAGGCCAAAGGCGGAGTTCTGTT
TTGTTATGAATGCAGGAATGAGGAAGTACTTCCTACAAGCCAATGATCAGCAGGACCTAGTGGAATGGGTAAATGTGTTAAACAAAGCTA
TAAAAATTACAGTACCAAAGCAGTCAGACTCACAGCCTAATTCTGATAACCTAAGTCGCCATGGTGAATGTGGGAAAAAGCAAGTGTCTT
ACAGAACTGATATTGTTGGTGGCGTACCCATCATTACTCCCACTCAGAAAGAAGAAGTAAATGAATGTGGTGAAAGTATTGACAGAAATA
ATCTGAAACGGTCACAAAGCCATCTTCCTTACTTTACTCCTAAACCACCTCAAGATAGTGCGGTTATCAAAGCTGGATATTGTGTAAAAC
AAGGAGCAGTGATGAAAAACTGGAAGAGAAGATATTTTCAATTGGATGAAAACACAATAGGCTACTTCAAATCTGAACTGGAAAAGGAAC
CTCTTCGTGTAATACCACTTAAAGAGGTTCATAAAGTCCAGGAATGTAAGCAAAGAATAAAGAAATAGAAGAACTCACCAAGATTTGTGA
CGAACTGATTGCCAAAATGGGGAAAAGCTAACTCTGAACCGAATGTTTTGGACTTAACTGTTGCGTGCAATATGACCGTCGGCACACTGC
TGTTCCTCCAGTTCCATGGACAGGTTCTGTTTTCACTTTTTCGTATGCACTACTGTATTTCCTTTCTAAATAAAATTGATTTGATTGTAT
GCAGTACTAAGGAGACTATCAGAATTTCTTGCTATTGGTTTGCATTTTCCTAGTATAATTCATAGCAAGTTGACCTCAGAGTTCCTGTAT
CAGGGAGATTGTCTGATTCTCTAATAAAAGACACATTGCTGACCTTGGCCTTGCCCTTTGTACACAAGTTCCCAGGGTGAGCAGCTTTTG
GATTTAATATGAACATGTACAGCGTGCATAGGGACTCTTGCCTTAAGGAGTGTAAACTTGATCTGCATTTGCTGATTTGTTTTTAAAAAA

>66156_66156_25_PLEKHA1-TACC2_PLEKHA1_chr10_124183779_ENST00000538022_TACC2_chr10_124013506_ENST00000334433_length(amino acids)=252AA_BP=
MPYVDRQNRICGFLDIEENENSGKFLRRYFILDTREDSFVWYMDNPQNLPSGSSRVGAIKLTYISKVSDATKLRPKAEFCFVMNAGMRKY
FLQANDQQDLVEWVNVLNKAIKITVPKQSDSQPNSDNLSRHGECGKKQVSYRTDIVGGVPIITPTQKEEVNECGESIDRNNLKRSQSHLP

--------------------------------------------------------------
>66156_66156_26_PLEKHA1-TACC2_PLEKHA1_chr10_124183779_ENST00000538022_TACC2_chr10_124013506_ENST00000358010_length(transcript)=1505nt_BP=955nt
AAAGTTGCTATGTCATTTTGCATTTCCACCAGCAATATATGATAGTTCGTTTATTTCACATCTTTGACAGCATTTAGTGTTGTCAGGGTT
TTTTTTGTTTGTTTTAGACATTTTAGTAGTCTGGCTCTTGCTGATTGAATTCCTTTGGTGCAGTTTAGCATGTTCCTCTGTGTTCTGCAT
CTCCTGTAGTGTAATGTTCAAGCTCAGAAATGCCTTATGTGGATCGTCAGAATCGCATTTGTGGTTTTCTAGACATTGAAGAAAATGAAA
ACAGTGGGAAATTTCTTCGAAGGTACTTCATACTGGATACCAGAGAAGATAGTTTCGTGTGGTACATGGATAATCCACAGAACCTACCTT
CTGGATCATCACGTGTTGGAGCCATTAAGCTTACCTACATTTCAAAGGTTAGCGATGCTACTAAGCTAAGGCCAAAGGCGGAGTTCTGTT
TTGTTATGAATGCAGGAATGAGGAAGTACTTCCTACAAGCCAATGATCAGCAGGACCTAGTGGAATGGGTAAATGTGTTAAACAAAGCTA
TAAAAATTACAGTACCAAAGCAGTCAGACTCACAGCCTAATTCTGATAACCTAAGTCGCCATGGTGAATGTGGGAAAAAGCAAGTGTCTT
ACAGAACTGATATTGTTGGTGGCGTACCCATCATTACTCCCACTCAGAAAGAAGAAGTAAATGAATGTGGTGAAAGTATTGACAGAAATA
ATCTGAAACGGTCACAAAGCCATCTTCCTTACTTTACTCCTAAACCACCTCAAGATAGTGCGGTTATCAAAGCTGGATATTGTGTAAAAC
AAGGAGCAGTGATGAAAAACTGGAAGAGAAGATATTTTCAATTGGATGAAAACACAATAGGCTACTTCAAATCTGAACTGGAAAAGGAAC
CTCTTCGTGTAATACCACTTAAAGAGGTTCATAAAGTCCAGGAATGTAAGCAAAGAATAAAGAAATAGAAGAACTCACCAAGATTTGTGA
CGAACTGATTGCCAAAATGGGGAAAAGCTAACTCTGAACCGAATGTTTTGGACTTAACTGTTGCGTGCAATATGACCGTCGGCACACTGC
TGTTCCTCCAGTTCCATGGACAGGTTCTGTTTTCACTTTTTCGTATGCACTACTGTATTTCCTTTCTAAATAAAATTGATTTGATTGTAT
GCAGTACTAAGGAGACTATCAGAATTTCTTGCTATTGGTTTGCATTTTCCTAGTATAATTCATAGCAAGTTGACCTCAGAGTTCCTGTAT
CAGGGAGATTGTCTGATTCTCTAATAAAAGACACATTGCTGACCTTGGCCTTGCCCTTTGTACACAAGTTCCCAGGGTGAGCAGCTTTTG
GATTTAATATGAACATGTACAGCGTGCATAGGGACTCTTGCCTTAAGGAGTGTAAACTTGATCTGCATTTGCTGATTTGTTTTTAAAAAA

>66156_66156_26_PLEKHA1-TACC2_PLEKHA1_chr10_124183779_ENST00000538022_TACC2_chr10_124013506_ENST00000358010_length(amino acids)=252AA_BP=
MPYVDRQNRICGFLDIEENENSGKFLRRYFILDTREDSFVWYMDNPQNLPSGSSRVGAIKLTYISKVSDATKLRPKAEFCFVMNAGMRKY
FLQANDQQDLVEWVNVLNKAIKITVPKQSDSQPNSDNLSRHGECGKKQVSYRTDIVGGVPIITPTQKEEVNECGESIDRNNLKRSQSHLP

--------------------------------------------------------------
>66156_66156_27_PLEKHA1-TACC2_PLEKHA1_chr10_124183779_ENST00000538022_TACC2_chr10_124013506_ENST00000368999_length(transcript)=1448nt_BP=955nt
AAAGTTGCTATGTCATTTTGCATTTCCACCAGCAATATATGATAGTTCGTTTATTTCACATCTTTGACAGCATTTAGTGTTGTCAGGGTT
TTTTTTGTTTGTTTTAGACATTTTAGTAGTCTGGCTCTTGCTGATTGAATTCCTTTGGTGCAGTTTAGCATGTTCCTCTGTGTTCTGCAT
CTCCTGTAGTGTAATGTTCAAGCTCAGAAATGCCTTATGTGGATCGTCAGAATCGCATTTGTGGTTTTCTAGACATTGAAGAAAATGAAA
ACAGTGGGAAATTTCTTCGAAGGTACTTCATACTGGATACCAGAGAAGATAGTTTCGTGTGGTACATGGATAATCCACAGAACCTACCTT
CTGGATCATCACGTGTTGGAGCCATTAAGCTTACCTACATTTCAAAGGTTAGCGATGCTACTAAGCTAAGGCCAAAGGCGGAGTTCTGTT
TTGTTATGAATGCAGGAATGAGGAAGTACTTCCTACAAGCCAATGATCAGCAGGACCTAGTGGAATGGGTAAATGTGTTAAACAAAGCTA
TAAAAATTACAGTACCAAAGCAGTCAGACTCACAGCCTAATTCTGATAACCTAAGTCGCCATGGTGAATGTGGGAAAAAGCAAGTGTCTT
ACAGAACTGATATTGTTGGTGGCGTACCCATCATTACTCCCACTCAGAAAGAAGAAGTAAATGAATGTGGTGAAAGTATTGACAGAAATA
ATCTGAAACGGTCACAAAGCCATCTTCCTTACTTTACTCCTAAACCACCTCAAGATAGTGCGGTTATCAAAGCTGGATATTGTGTAAAAC
AAGGAGCAGTGATGAAAAACTGGAAGAGAAGATATTTTCAATTGGATGAAAACACAATAGGCTACTTCAAATCTGAACTGGAAAAGGAAC
CTCTTCGTGTAATACCACTTAAAGAGGTTCATAAAGTCCAGGAATGTAAGCAAAGAATAAAGAAATAGAAGAACTCACCAAGATTTGTGA
CGAACTGATTGCCAAAATGGGGAAAAGCTAACTCTGAACCGAATGTTTTGGACTTAACTGTTGCGTGCAATATGACCGTCGGCACACTGC
TGTTCCTCCAGTTCCATGGACAGGTTCTGTTTTCACTTTTTCGTATGCACTACTGTATTTCCTTTCTAAATAAAATTGATTTGATTGTAT
GCAGTACTAAGGAGACTATCAGAATTTCTTGCTATTGGTTTGCATTTTCCTAGTATAATTCATAGCAAGTTGACCTCAGAGTTCCTGTAT
CAGGGAGATTGTCTGATTCTCTAATAAAAGACACATTGCTGACCTTGGCCTTGCCCTTTGTACACAAGTTCCCAGGGTGAGCAGCTTTTG
GATTTAATATGAACATGTACAGCGTGCATAGGGACTCTTGCCTTAAGGAGTGTAAACTTGATCTGCATTTGCTGATTTGTTTTTAAAAAA

>66156_66156_27_PLEKHA1-TACC2_PLEKHA1_chr10_124183779_ENST00000538022_TACC2_chr10_124013506_ENST00000368999_length(amino acids)=252AA_BP=
MPYVDRQNRICGFLDIEENENSGKFLRRYFILDTREDSFVWYMDNPQNLPSGSSRVGAIKLTYISKVSDATKLRPKAEFCFVMNAGMRKY
FLQANDQQDLVEWVNVLNKAIKITVPKQSDSQPNSDNLSRHGECGKKQVSYRTDIVGGVPIITPTQKEEVNECGESIDRNNLKRSQSHLP

--------------------------------------------------------------
>66156_66156_28_PLEKHA1-TACC2_PLEKHA1_chr10_124183779_ENST00000538022_TACC2_chr10_124013506_ENST00000453444_length(transcript)=1310nt_BP=955nt
AAAGTTGCTATGTCATTTTGCATTTCCACCAGCAATATATGATAGTTCGTTTATTTCACATCTTTGACAGCATTTAGTGTTGTCAGGGTT
TTTTTTGTTTGTTTTAGACATTTTAGTAGTCTGGCTCTTGCTGATTGAATTCCTTTGGTGCAGTTTAGCATGTTCCTCTGTGTTCTGCAT
CTCCTGTAGTGTAATGTTCAAGCTCAGAAATGCCTTATGTGGATCGTCAGAATCGCATTTGTGGTTTTCTAGACATTGAAGAAAATGAAA
ACAGTGGGAAATTTCTTCGAAGGTACTTCATACTGGATACCAGAGAAGATAGTTTCGTGTGGTACATGGATAATCCACAGAACCTACCTT
CTGGATCATCACGTGTTGGAGCCATTAAGCTTACCTACATTTCAAAGGTTAGCGATGCTACTAAGCTAAGGCCAAAGGCGGAGTTCTGTT
TTGTTATGAATGCAGGAATGAGGAAGTACTTCCTACAAGCCAATGATCAGCAGGACCTAGTGGAATGGGTAAATGTGTTAAACAAAGCTA
TAAAAATTACAGTACCAAAGCAGTCAGACTCACAGCCTAATTCTGATAACCTAAGTCGCCATGGTGAATGTGGGAAAAAGCAAGTGTCTT
ACAGAACTGATATTGTTGGTGGCGTACCCATCATTACTCCCACTCAGAAAGAAGAAGTAAATGAATGTGGTGAAAGTATTGACAGAAATA
ATCTGAAACGGTCACAAAGCCATCTTCCTTACTTTACTCCTAAACCACCTCAAGATAGTGCGGTTATCAAAGCTGGATATTGTGTAAAAC
AAGGAGCAGTGATGAAAAACTGGAAGAGAAGATATTTTCAATTGGATGAAAACACAATAGGCTACTTCAAATCTGAACTGGAAAAGGAAC
CTCTTCGTGTAATACCACTTAAAGAGGTTCATAAAGTCCAGGAATGTAAGCAAAGAATAAAGAAATAGAAGAACTCACCAAGATTTGTGA
CGAACTGATTGCCAAAATGGGGAAAAGCTAACTCTGAACCGAATGTTTTGGACTTAACTGTTGCGTGCAATATGACCGTCGGCACACTGC
TGTTCCTCCAGTTCCATGGACAGGTTCTGTTTTCACTTTTTCGTATGCACTACTGTATTTCCTTTCTAAATAAAATTGATTTGATTGTAT
GCAGTACTAAGGAGACTATCAGAATTTCTTGCTATTGGTTTGCATTTTCCTAGTATAATTCATAGCAAGTTGACCTCAGAGTTCCTGTAT

>66156_66156_28_PLEKHA1-TACC2_PLEKHA1_chr10_124183779_ENST00000538022_TACC2_chr10_124013506_ENST00000453444_length(amino acids)=252AA_BP=
MPYVDRQNRICGFLDIEENENSGKFLRRYFILDTREDSFVWYMDNPQNLPSGSSRVGAIKLTYISKVSDATKLRPKAEFCFVMNAGMRKY
FLQANDQQDLVEWVNVLNKAIKITVPKQSDSQPNSDNLSRHGECGKKQVSYRTDIVGGVPIITPTQKEEVNECGESIDRNNLKRSQSHLP

--------------------------------------------------------------
>66156_66156_29_PLEKHA1-TACC2_PLEKHA1_chr10_124183779_ENST00000538022_TACC2_chr10_124013506_ENST00000515273_length(transcript)=1310nt_BP=955nt
AAAGTTGCTATGTCATTTTGCATTTCCACCAGCAATATATGATAGTTCGTTTATTTCACATCTTTGACAGCATTTAGTGTTGTCAGGGTT
TTTTTTGTTTGTTTTAGACATTTTAGTAGTCTGGCTCTTGCTGATTGAATTCCTTTGGTGCAGTTTAGCATGTTCCTCTGTGTTCTGCAT
CTCCTGTAGTGTAATGTTCAAGCTCAGAAATGCCTTATGTGGATCGTCAGAATCGCATTTGTGGTTTTCTAGACATTGAAGAAAATGAAA
ACAGTGGGAAATTTCTTCGAAGGTACTTCATACTGGATACCAGAGAAGATAGTTTCGTGTGGTACATGGATAATCCACAGAACCTACCTT
CTGGATCATCACGTGTTGGAGCCATTAAGCTTACCTACATTTCAAAGGTTAGCGATGCTACTAAGCTAAGGCCAAAGGCGGAGTTCTGTT
TTGTTATGAATGCAGGAATGAGGAAGTACTTCCTACAAGCCAATGATCAGCAGGACCTAGTGGAATGGGTAAATGTGTTAAACAAAGCTA
TAAAAATTACAGTACCAAAGCAGTCAGACTCACAGCCTAATTCTGATAACCTAAGTCGCCATGGTGAATGTGGGAAAAAGCAAGTGTCTT
ACAGAACTGATATTGTTGGTGGCGTACCCATCATTACTCCCACTCAGAAAGAAGAAGTAAATGAATGTGGTGAAAGTATTGACAGAAATA
ATCTGAAACGGTCACAAAGCCATCTTCCTTACTTTACTCCTAAACCACCTCAAGATAGTGCGGTTATCAAAGCTGGATATTGTGTAAAAC
AAGGAGCAGTGATGAAAAACTGGAAGAGAAGATATTTTCAATTGGATGAAAACACAATAGGCTACTTCAAATCTGAACTGGAAAAGGAAC
CTCTTCGTGTAATACCACTTAAAGAGGTTCATAAAGTCCAGGAATGTAAGCAAAGAATAAAGAAATAGAAGAACTCACCAAGATTTGTGA
CGAACTGATTGCCAAAATGGGGAAAAGCTAACTCTGAACCGAATGTTTTGGACTTAACTGTTGCGTGCAATATGACCGTCGGCACACTGC
TGTTCCTCCAGTTCCATGGACAGGTTCTGTTTTCACTTTTTCGTATGCACTACTGTATTTCCTTTCTAAATAAAATTGATTTGATTGTAT
GCAGTACTAAGGAGACTATCAGAATTTCTTGCTATTGGTTTGCATTTTCCTAGTATAATTCATAGCAAGTTGACCTCAGAGTTCCTGTAT

>66156_66156_29_PLEKHA1-TACC2_PLEKHA1_chr10_124183779_ENST00000538022_TACC2_chr10_124013506_ENST00000515273_length(amino acids)=252AA_BP=
MPYVDRQNRICGFLDIEENENSGKFLRRYFILDTREDSFVWYMDNPQNLPSGSSRVGAIKLTYISKVSDATKLRPKAEFCFVMNAGMRKY
FLQANDQQDLVEWVNVLNKAIKITVPKQSDSQPNSDNLSRHGECGKKQVSYRTDIVGGVPIITPTQKEEVNECGESIDRNNLKRSQSHLP

--------------------------------------------------------------
>66156_66156_30_PLEKHA1-TACC2_PLEKHA1_chr10_124183779_ENST00000538022_TACC2_chr10_124013506_ENST00000515603_length(transcript)=1313nt_BP=955nt
AAAGTTGCTATGTCATTTTGCATTTCCACCAGCAATATATGATAGTTCGTTTATTTCACATCTTTGACAGCATTTAGTGTTGTCAGGGTT
TTTTTTGTTTGTTTTAGACATTTTAGTAGTCTGGCTCTTGCTGATTGAATTCCTTTGGTGCAGTTTAGCATGTTCCTCTGTGTTCTGCAT
CTCCTGTAGTGTAATGTTCAAGCTCAGAAATGCCTTATGTGGATCGTCAGAATCGCATTTGTGGTTTTCTAGACATTGAAGAAAATGAAA
ACAGTGGGAAATTTCTTCGAAGGTACTTCATACTGGATACCAGAGAAGATAGTTTCGTGTGGTACATGGATAATCCACAGAACCTACCTT
CTGGATCATCACGTGTTGGAGCCATTAAGCTTACCTACATTTCAAAGGTTAGCGATGCTACTAAGCTAAGGCCAAAGGCGGAGTTCTGTT
TTGTTATGAATGCAGGAATGAGGAAGTACTTCCTACAAGCCAATGATCAGCAGGACCTAGTGGAATGGGTAAATGTGTTAAACAAAGCTA
TAAAAATTACAGTACCAAAGCAGTCAGACTCACAGCCTAATTCTGATAACCTAAGTCGCCATGGTGAATGTGGGAAAAAGCAAGTGTCTT
ACAGAACTGATATTGTTGGTGGCGTACCCATCATTACTCCCACTCAGAAAGAAGAAGTAAATGAATGTGGTGAAAGTATTGACAGAAATA
ATCTGAAACGGTCACAAAGCCATCTTCCTTACTTTACTCCTAAACCACCTCAAGATAGTGCGGTTATCAAAGCTGGATATTGTGTAAAAC
AAGGAGCAGTGATGAAAAACTGGAAGAGAAGATATTTTCAATTGGATGAAAACACAATAGGCTACTTCAAATCTGAACTGGAAAAGGAAC
CTCTTCGTGTAATACCACTTAAAGAGGTTCATAAAGTCCAGGAATGTAAGCAAAGAATAAAGAAATAGAAGAACTCACCAAGATTTGTGA
CGAACTGATTGCCAAAATGGGGAAAAGCTAACTCTGAACCGAATGTTTTGGACTTAACTGTTGCGTGCAATATGACCGTCGGCACACTGC
TGTTCCTCCAGTTCCATGGACAGGTTCTGTTTTCACTTTTTCGTATGCACTACTGTATTTCCTTTCTAAATAAAATTGATTTGATTGTAT
GCAGTACTAAGGAGACTATCAGAATTTCTTGCTATTGGTTTGCATTTTCCTAGTATAATTCATAGCAAGTTGACCTCAGAGTTCCTGTAT

>66156_66156_30_PLEKHA1-TACC2_PLEKHA1_chr10_124183779_ENST00000538022_TACC2_chr10_124013506_ENST00000515603_length(amino acids)=252AA_BP=
MPYVDRQNRICGFLDIEENENSGKFLRRYFILDTREDSFVWYMDNPQNLPSGSSRVGAIKLTYISKVSDATKLRPKAEFCFVMNAGMRKY
FLQANDQQDLVEWVNVLNKAIKITVPKQSDSQPNSDNLSRHGECGKKQVSYRTDIVGGVPIITPTQKEEVNECGESIDRNNLKRSQSHLP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PLEKHA1-TACC2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PLEKHA1-TACC2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PLEKHA1-TACC2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource