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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PLEKHA5-LSM3 (FusionGDB2 ID:66183)

Fusion Gene Summary for PLEKHA5-LSM3

check button Fusion gene summary
Fusion gene informationFusion gene name: PLEKHA5-LSM3
Fusion gene ID: 66183
HgeneTgene
Gene symbol

PLEKHA5

LSM3

Gene ID

54477

27258

Gene namepleckstrin homology domain containing A5LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated
SynonymsPEPP-2|PEPP2SMX4|USS2|YLR438C
Cytomap

12p12.3

3p25.1

Type of geneprotein-codingprotein-coding
Descriptionpleckstrin homology domain-containing family A member 5PH domain-containing family A member 5phosphoinositol 3-phosphate-binding protein-2pleckstrin homology domain containing, family A member 5U6 snRNA-associated Sm-like protein LSm3LSM3 U6 small nuclear RNA and mRNA degradation associatedLSM3 homolog, U6 small nuclear RNA associated
Modification date2020032020200313
UniProtAcc.

P62310

Ensembl transtripts involved in fusion geneENST00000299275, ENST00000317589, 
ENST00000355397, ENST00000359180, 
ENST00000424268, ENST00000429027, 
ENST00000538714, ENST00000539256, 
ENST00000543806, ENST00000309364, 
ENST00000510738, ENST00000540972, 
ENST00000306024, 
Fusion gene scores* DoF score19 X 17 X 12=38768 X 7 X 4=224
# samples 238
** MAII scorelog2(23/3876*10)=-4.07486280447071
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/224*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PLEKHA5 [Title/Abstract] AND LSM3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPLEKHA5(19475516)-LSM3(14223081), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneLSM3

GO:0000398

mRNA splicing, via spliceosome

10369684|10523320|28781166


check buttonFusion gene breakpoints across PLEKHA5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LSM3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAA176220PLEKHA5chr12

19475516

-LSM3chr3

14223081

+


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Fusion Gene ORF analysis for PLEKHA5-LSM3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000299275ENST00000306024PLEKHA5chr12

19475516

-LSM3chr3

14223081

+
In-frameENST00000317589ENST00000306024PLEKHA5chr12

19475516

-LSM3chr3

14223081

+
In-frameENST00000355397ENST00000306024PLEKHA5chr12

19475516

-LSM3chr3

14223081

+
In-frameENST00000359180ENST00000306024PLEKHA5chr12

19475516

-LSM3chr3

14223081

+
In-frameENST00000424268ENST00000306024PLEKHA5chr12

19475516

-LSM3chr3

14223081

+
In-frameENST00000429027ENST00000306024PLEKHA5chr12

19475516

-LSM3chr3

14223081

+
In-frameENST00000538714ENST00000306024PLEKHA5chr12

19475516

-LSM3chr3

14223081

+
In-frameENST00000539256ENST00000306024PLEKHA5chr12

19475516

-LSM3chr3

14223081

+
In-frameENST00000543806ENST00000306024PLEKHA5chr12

19475516

-LSM3chr3

14223081

+
intron-3CDSENST00000309364ENST00000306024PLEKHA5chr12

19475516

-LSM3chr3

14223081

+
intron-3CDSENST00000510738ENST00000306024PLEKHA5chr12

19475516

-LSM3chr3

14223081

+
intron-3CDSENST00000540972ENST00000306024PLEKHA5chr12

19475516

-LSM3chr3

14223081

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000359180PLEKHA5chr1219475516-ENST00000306024LSM3chr314223081+54292160862107673
ENST00000317589PLEKHA5chr1219475516-ENST00000306024LSM3chr314223081+54292160862107673
ENST00000355397PLEKHA5chr1219475516-ENST00000306024LSM3chr314223081+56032334862281731
ENST00000429027PLEKHA5chr1219475516-ENST00000306024LSM3chr314223081+56842415322362776
ENST00000539256PLEKHA5chr1219475516-ENST00000306024LSM3chr314223081+527620075631954463
ENST00000299275PLEKHA5chr1219475516-ENST00000306024LSM3chr314223081+5349208062027673
ENST00000538714PLEKHA5chr1219475516-ENST00000306024LSM3chr314223081+5521225242199731
ENST00000543806PLEKHA5chr1219475516-ENST00000306024LSM3chr314223081+531620472161994592
ENST00000424268PLEKHA5chr1219475516-ENST00000306024LSM3chr314223081+535220832162030604

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000359180ENST00000306024PLEKHA5chr1219475516-LSM3chr314223081+0.000812820.9991872
ENST00000317589ENST00000306024PLEKHA5chr1219475516-LSM3chr314223081+0.000812820.9991872
ENST00000355397ENST00000306024PLEKHA5chr1219475516-LSM3chr314223081+0.0010948870.99890506
ENST00000429027ENST00000306024PLEKHA5chr1219475516-LSM3chr314223081+0.0008143290.9991856
ENST00000539256ENST00000306024PLEKHA5chr1219475516-LSM3chr314223081+0.0008439450.999156
ENST00000299275ENST00000306024PLEKHA5chr1219475516-LSM3chr314223081+0.0007170260.999283
ENST00000538714ENST00000306024PLEKHA5chr1219475516-LSM3chr314223081+0.0009541040.9990459
ENST00000543806ENST00000306024PLEKHA5chr1219475516-LSM3chr314223081+0.000918840.99908113
ENST00000424268ENST00000306024PLEKHA5chr1219475516-LSM3chr314223081+0.0009106360.99908936

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Fusion Genomic Features for PLEKHA5-LSM3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PLEKHA5-LSM3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:19475516/chr3:14223081)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.LSM3

P62310

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320). {ECO:0000269|PubMed:10523320, ECO:0000269|PubMed:28781166}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePLEKHA5chr12:19475516chr3:14223081ENST00000299275-12610_4301375.3333333333333DomainWW 1
HgenePLEKHA5chr12:19475516chr3:14223081ENST00000299275-126169_26801375.3333333333333DomainPH
HgenePLEKHA5chr12:19475516chr3:14223081ENST00000299275-12656_8901375.3333333333333DomainWW 2
HgenePLEKHA5chr12:19475516chr3:14223081ENST00000309364-11310_430651.0DomainWW 1
HgenePLEKHA5chr12:19475516chr3:14223081ENST00000309364-113169_2680651.0DomainPH
HgenePLEKHA5chr12:19475516chr3:14223081ENST00000309364-11356_890651.0DomainWW 2
HgenePLEKHA5chr12:19475516chr3:14223081ENST00000317589-12710_4301410.6666666666667DomainWW 1
HgenePLEKHA5chr12:19475516chr3:14223081ENST00000317589-127169_26801410.6666666666667DomainPH
HgenePLEKHA5chr12:19475516chr3:14223081ENST00000317589-12756_8901410.6666666666667DomainWW 2
HgenePLEKHA5chr12:19475516chr3:14223081ENST00000355397-12810_4301405.6666666666667DomainWW 1
HgenePLEKHA5chr12:19475516chr3:14223081ENST00000355397-128169_26801405.6666666666667DomainPH
HgenePLEKHA5chr12:19475516chr3:14223081ENST00000355397-12856_8901405.6666666666667DomainWW 2
HgenePLEKHA5chr12:19475516chr3:14223081ENST00000359180-12410_4301291.6666666666667DomainWW 1
HgenePLEKHA5chr12:19475516chr3:14223081ENST00000359180-124169_26801291.6666666666667DomainPH
HgenePLEKHA5chr12:19475516chr3:14223081ENST00000359180-12456_8901291.6666666666667DomainWW 2
HgenePLEKHA5chr12:19475516chr3:14223081ENST00000429027-13210_4301532.6666666666667DomainWW 1
HgenePLEKHA5chr12:19475516chr3:14223081ENST00000429027-132169_26801532.6666666666667DomainPH
HgenePLEKHA5chr12:19475516chr3:14223081ENST00000429027-13256_8901532.6666666666667DomainWW 2
HgenePLEKHA5chr12:19475516chr3:14223081ENST00000538714-12810_4302126.3333333333335DomainWW 1
HgenePLEKHA5chr12:19475516chr3:14223081ENST00000538714-128169_26802126.3333333333335DomainPH
HgenePLEKHA5chr12:19475516chr3:14223081ENST00000538714-12856_8902126.3333333333335DomainWW 2
HgenePLEKHA5chr12:19475516chr3:14223081ENST00000540972-1410_43077.0DomainWW 1
HgenePLEKHA5chr12:19475516chr3:14223081ENST00000540972-14169_268077.0DomainPH
HgenePLEKHA5chr12:19475516chr3:14223081ENST00000540972-1456_89077.0DomainWW 2
HgenePLEKHA5chr12:19475516chr3:14223081ENST00000543806-12610_4301152.3333333333333DomainWW 1
HgenePLEKHA5chr12:19475516chr3:14223081ENST00000543806-126169_26801152.3333333333333DomainPH
HgenePLEKHA5chr12:19475516chr3:14223081ENST00000543806-12656_8901152.3333333333333DomainWW 2


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Fusion Gene Sequence for PLEKHA5-LSM3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>66183_66183_1_PLEKHA5-LSM3_PLEKHA5_chr12_19475516_ENST00000299275_LSM3_chr3_14223081_ENST00000306024_length(transcript)=5349nt_BP=2080nt
TCAGACATGGCGGCGGATCTGAACCTGGAGTGGATCTCCCTGCCCCGGTCCTGGACTTACGGGATCACCAGGGGCGGCCGAGTCTTCTTC
ATCAACGAGGAGGCCAAGAGCACCACCTGGCTGCACCCCGTCACCGGCGAGGCGGTGGTCACCGGACACCGGCGGCAGAGCACAGATTTG
CCTACTGGCTGGGAAGAAGCATATACTTTTGAAGGTGCAAGATACTATATAAACCATAATGAAAGGAAAGTGACCTGCAAACATCCAGTC
ACAGGACAACCATCACAGGACAATTGTATTTTTGTAGTGAATGAACAGACTGTTGCAACCATGACATCTGAAGAAAAGAAGGAACGGCCA
ATAAGTATGATAAATGAAGCTTCTAACTATAACGTGACTTCAGATTATGCAGTGCATCCAATGAGCCCTGTAGGCAGAACTTCACGAGCT
TCAAAAAAAGTTCATAATTTTGGAAAGAGGTCAAATTCAATTAAAAGGAATCCTAATGCACCGGTTGTCAGACGAGGTTGGCTTTATAAA
CAGGACAGTACTGGCATGAAATTGTGGAAGAAACGCTGGTTTGTGCTTTCTGACCTTTGCCTCTTTTATTATAGAGATGAGAAAGAAGAG
GGTATCCTGGGAAGCATACTGTTACCTAGTTTTCAGATAGCTTTGCTTACCTCTGAAGATCACATTAATCGCAAATATGCTTTTAAGGCA
GCCCATCCAAACATGCGGACCTATTATTTCTGCACTGATACAGGAAAGGAAATGGAGTTGTGGATGAAAGCCATGTTAGATGCTGCCCTA
GTACAGACAGAACCTGTGAAAAGAGTGGACAAGATTACATCTGAAAATGCACCAACTAAAGAAACCAATAACATTCCCAACCATAGAGTG
CTAATTAAACCAGAGATCCAAAACAATCAAAAAAACAAGGAAATGAGCAAAATTGAAGAAAAAAAGGCATTAGAAGCTGAAAAATATGGA
TTTCAGAAGGATGGTCAAGATAGACCCTTAACAAAAATTAATAGTGTAAAGCTGAATTCTCTGCCATCTGAATATGAGAGTGGGTCAGCA
TGCCCTGCTCAGACTGTGCACTACAGACCAATCAACTTGAGCAGTTCAGAGAACAAAATAGTCAATGTTAGCCTGGCAGATCTTAGAGGT
GGAAATCGCCCCAATACAGGGCCCTTATACACAGAGGCCGATCGAGTCATACAGAGAACAAATTCAATGCAGCAGTTGGAACAGTGGATT
AAAATCCAGAAGGGGAGGGGTCATGAAGAAGAAACCAGGGGAGTAATTTCTTACCAAACATTACCAAGAAATATGCCAAGTCACAGAGCC
CAGATTATGGCCCGCTACCCTGAAGGTTATAGAACACTCCCAAGAAACAGCAAGACAAGGCCTGAAAGTATCTGCAGTGTAACCCCTTCC
ACTCATGACAAGACATTAGGACCCGGAGCGGAGGAGAAACGGAGGTCCATGAGAGATGACACAATGTGGCAGCTCTACGAATGGCAGCAG
CGTCAGTTTTATAACAAACAGAGCACCCTCCCTCGACACAGTACTTTGAGTAGTCCCAAAACCATGGTAAATATTTCTGACCAGACAATG
CACTCTATTCCCACATCACCTTCCCACGGGTCAATAGCTGCTTATCAGGGATACTCCCCTCAACGAACTTACAGATCGGAAGTGTCTTCA
CCAATTCAGAGAGGAGATGTGACAATAGACCGCAGACACAGGGCCCATCACCCTAAGCATGTCTATGTGCCTGACAGAAGGTCAGTGCCA
GCTGGCCTGACTTTACAGTCTGTTAGTCCCCAGAGCCTCCAAGGGAAAACGCTGTCACAAGATGAAGGTAGAGGCACATTATACAAATAC
AGACCTGAAGAAGTAGATATTGATGCCAAGTTAAGCCGATTATGTGAACAAGATAAAGTGGTGCATGCTCTGGAAGAGAAACTTCAGCAA
CTCCACAAGGAGAAAAGCCATTCAGACAGTGGTGTTACAAAGGGATGATTTACAAAATGGACTGCTTAGTACGTGTCGAGAACTTTCTCG
AGCCACTGCCAGGAGCCCCTGGATCTTATCAGGCTCAGCCTAGATGAGCGAATTTATGTGAAAATGAGAAATGACCGAGAGCTTCGAGGC
AGATTACATGCTTATGATCAACATTTAAATATGATCTTGGGAGATGTGGAAGAAACTGTGACTACTATAGAAATTGATGAAGAAACATAT
GAAGAGATATATAAATCAACGAAACGGAATATTCCAATGCTCTTTGTCCGGGGAGATGGCGTTGTCCTGGTTGCCCCTCCACTGAGAGTT
GGCTGAAACAAAGAATTTGTCCTGTATGGAAAACGGGAGACTTTGTACAGTGGCCTCTCTAAAAGTACAAAACATTCATAAGAGAAACCT
GCATACATTTTGATATTAAGAAATAATTCCGGGGATTCTTCCACTCCTGAAATGAGTTGATTTGCAGATAACTCACAACTTCTTAAGCTA
AATGGTATTTTCATTTTTCTCAAGCTCTCCAATAAATATGACCACCAAGATGCAGAACTCTTTCAGGACTTCTTTTGCTCCATTATTCTC
ACAGATACTTACTGATTTTTCTTTTCTTTAAATTGGTGTTTCCTTGTAGATTTTTTTAAGTGCGGTCTTCTGTCTTGTGAATTATTTAAA
GTAAGCATGTCTTACCTTCACTTAGCACACATTTGCAGTGCACCTACTGTGTTTGAGGCACCAGGTTTGAGTGCTGGGAACCAGAGTTTT
ATCAAAATGCTTTCTGGGCCAGACATGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGATCACCTGAGGTCAG
GCGTTTGAGACCAGCCTGGCCAACATGGTGAAACCCTTTCTCTACTGAAAATATAAAAATTAGCCAGGCGTGGTGGCGCATACTTGTAAT
CCCAGCTACTCAGGAGGCTGAGGCAGTAGACGCTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCAAGATCACACCATTGCACTTCAACC
TGGTCAACAGAGCGAGACTCCGTGTCAAAAAAAAAAAAAAAAAAGTTTTCTGCCCTCAAGTCTTCTGGGGAGGCAGATGTTTAAACCAAC
AATTGCAGGCAGTAAGATTAGTGCTGATAGAATCATGCACATGCAGGATGCCATAGGAGCATGGGGAAGAGCACCCAAATATGGGAGAAA
GGGGCAGAGGGACATTGTAAACATCAACCCTGCAGTAGAAGACAGAGCAAAGCATGATTTCTCTTTTCTCTGGCCTGATTTAATTCTAAG
GTCAGACGTTCAGCTTGATCATAACCTGTTTATAATTATGACTCAGACCATTTTTCCACTCTTGGATCATTGGCCATTAATGATGAGGGG
TCTCAAACAACATGTCTCAGTGACACAGTAAAGCAGAAATTGGCTGAAAGCAAAGCTGTTTTTATTTCTAGCTTCAGTCAGCACATAATG
CTTAAAACCTAAAGAGGAAAGTAAAAGCGTGTTACAATCTCTCAAACTTTATCAAGACAGGGCTTAGAACCTGACATCCTCCGCTATGGT
CATTCCATTTTGAAATGTAGAAAATCCAACTTGTGGATGGTTTGTCTGTAAATGAGCTGAATGTGTGTGCGTGTTCATTATCAAGCACGA
TATGCTCACAAATGCACAGTACTTTAAGCCTTGTGCAAGAAAGATGCTTTCAGTAAACATATTTAAAAGGTTTTATTTTCCTTACTAATG
GTACATGCCCCTGCAAGTTCATGGAGAAGAGAAAAACAAGTGTGGGTGAGCTGATGGAGGCTTCATCTTAGGTGAGGAGGCAGGAGAGAC
ACCCTCCCTTCACTTGTGCCATCCCCACGCTTTGTCCTTAAGCTGTAGTGGTCCCAGGAGATAACCTGTTTACAGCAGCCCATTCAGTAT
TGAAAAATGAACTCCCTCCTGCAGAATGTTAGAAGAAACAACCTCAAAGACCTCAGGCCGCCTGTGGTCATTAGTATGTGGCAGCAAGAT
TGAACCTGCCTGCCTCCTACCTGTGTGAGCCTGTGGTGTGGGTGTGGTACCAAGGCCCTGGCTCTGGGCAGTCTGTTGGCTCCTGGTGTT
CACTAAGGCGTGGGGTGACAGGCCATCTGGCCTCGCTCTGCCAGTCTGCAGTTCTCCCCAGCACTGCATTCATTTTTAGTGGTTTCTGAT
AGTCACACTGAATTCCTGGACACTTTCTTCTCTTCATTCTTAGTTATCTTTCTCCTTTTTCTCCTGGAACTGATAGTTTACACTAAAACT
TTTGGCTGTGAGGACTTGATTATACACATTTCTAAAACCCATGAACCTTAATATCTGACACTGTTACTCTCATATGCACACACAACTAAA
ACATACCAACCTACTTCATTTCCTAGCTGCTAAGATACAAGGGGAGGGACAATAAAAGGTTAACTGCAGAATAGCCACCTATGTGTCAGG
AAATGGAGGGAGGGGAGGCAATGTGTGAGTCCTTTTGGAGCTGGGACTCAATCCACAACAGAGACAGCTCAAGCAGGGCCCTGCCATGGT
CCACACTGAGGTTTCCTCTGCAGTGGTGCTGTCCACTGAGGGGTTATGGTGTGAGGGCCCCTGGGAGCCACGCCTTGGACTTCTGAGTCT
GCAGAGCACTCGGCTCCAGCCAGCTGGATGGCAGGTGGTCAGTGGAGCTGGTGACTGGTGGTTTCTGCAATGAGGTGTCAGATTAGCCTA
AGGGAAGCCTCTTCAGCAAGTATCATGCCTGGATCCCGGTCTTGGTTGTTTTATGAGAGGCCGATATGAATTGCCATTGCCTCCCACAAA
GAAAAATGGACAAAATATGGGACCACATCTTTGAGATGAAATGTGCCCAAAATGAAAAGTAACTTGAGTATCCCAAGTTAAACTTAATCA
TTAGCTGCAAATGGACGATTTTCAAATTTCAAATAGTGATTTTTGAAGATTTGCCCAAACTAGAGTACTATCCCTCTTCACACTAAGAGG
CAGAAAGTGGTTTCACACACCCTTTTATTTAATCAGCTAAAGTGGGTGCGGTGACACACACCTGTAAACTCAACCACTAAGGAGACTGAG
GCGGGAGGATTACTTGAGCCCAGGAGTTCGAGATCAGCCTGAGCAACATAACAAGACCCTGTCTCAAATAATACTTAGCTATTACCCATA
TTGCTTTTAGCCTGCTGCCAGGAGGGGAGAAATGTTATTGTTTGAACAGATGTCAGATGTGAGTAATGCTCAGCTGTGTTCAATGTAGAA

>66183_66183_1_PLEKHA5-LSM3_PLEKHA5_chr12_19475516_ENST00000299275_LSM3_chr3_14223081_ENST00000306024_length(amino acids)=673AA_BP=
MAADLNLEWISLPRSWTYGITRGGRVFFINEEAKSTTWLHPVTGEAVVTGHRRQSTDLPTGWEEAYTFEGARYYINHNERKVTCKHPVTG
QPSQDNCIFVVNEQTVATMTSEEKKERPISMINEASNYNVTSDYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNAPVVRRGWLYKQD
STGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSEDHINRKYAFKAAHPNMRTYYFCTDTGKEMELWMKAMLDAALVQ
TEPVKRVDKITSENAPTKETNNIPNHRVLIKPEIQNNQKNKEMSKIEEKKALEAEKYGFQKDGQDRPLTKINSVKLNSLPSEYESGSACP
AQTVHYRPINLSSSENKIVNVSLADLRGGNRPNTGPLYTEADRVIQRTNSMQQLEQWIKIQKGRGHEEETRGVISYQTLPRNMPSHRAQI
MARYPEGYRTLPRNSKTRPESICSVTPSTHDKTLGPGAEEKRRSMRDDTMWQLYEWQQRQFYNKQSTLPRHSTLSSPKTMVNISDQTMHS
IPTSPSHGSIAAYQGYSPQRTYRSEVSSPIQRGDVTIDRRHRAHHPKHVYVPDRRSVPAGLTLQSVSPQSLQGKTLSQDEGRGTLYKYRP

--------------------------------------------------------------
>66183_66183_2_PLEKHA5-LSM3_PLEKHA5_chr12_19475516_ENST00000317589_LSM3_chr3_14223081_ENST00000306024_length(transcript)=5429nt_BP=2160nt
GCGCTCCCTTCGCTCGCTCGTTCCCTCCTCCCTCGGCAGCCGCGGCGGCAGCAGGAGAAGGCGGCGGCGGCGGCTAGGGATCAGACATGG
CGGCGGATCTGAACCTGGAGTGGATCTCCCTGCCCCGGTCCTGGACTTACGGGATCACCAGGGGCGGCCGAGTCTTCTTCATCAACGAGG
AGGCCAAGAGCACCACCTGGCTGCACCCCGTCACCGGCGAGGCGGTGGTCACCGGACACCGGCGGCAGAGCACAGATTTGCCTACTGGCT
GGGAAGAAGCATATACTTTTGAAGGTGCAAGATACTATATAAACCATAATGAAAGGAAAGTGACCTGCAAACATCCAGTCACAGGACAAC
CATCACAGGACAATTGTATTTTTGTAGTGAATGAACAGACTGTTGCAACCATGACATCTGAAGAAAAGAAGGAACGGCCAATAAGTATGA
TAAATGAAGCTTCTAACTATAACGTGACTTCAGATTATGCAGTGCATCCAATGAGCCCTGTAGGCAGAACTTCACGAGCTTCAAAAAAAG
TTCATAATTTTGGAAAGAGGTCAAATTCAATTAAAAGGAATCCTAATGCACCGGTTGTCAGACGAGGTTGGCTTTATAAACAGGACAGTA
CTGGCATGAAATTGTGGAAGAAACGCTGGTTTGTGCTTTCTGACCTTTGCCTCTTTTATTATAGAGATGAGAAAGAAGAGGGTATCCTGG
GAAGCATACTGTTACCTAGTTTTCAGATAGCTTTGCTTACCTCTGAAGATCACATTAATCGCAAATATGCTTTTAAGGCAGCCCATCCAA
ACATGCGGACCTATTATTTCTGCACTGATACAGGAAAGGAAATGGAGTTGTGGATGAAAGCCATGTTAGATGCTGCCCTAGTACAGACAG
AACCTGTGAAAAGAGTGGACAAGATTACATCTGAAAATGCACCAACTAAAGAAACCAATAACATTCCCAACCATAGAGTGCTAATTAAAC
CAGAGATCCAAAACAATCAAAAAAACAAGGAAATGAGCAAAATTGAAGAAAAAAAGGCATTAGAAGCTGAAAAATATGGATTTCAGAAGG
ATGGTCAAGATAGACCCTTAACAAAAATTAATAGTGTAAAGCTGAATTCTCTGCCATCTGAATATGAGAGTGGGTCAGCATGCCCTGCTC
AGACTGTGCACTACAGACCAATCAACTTGAGCAGTTCAGAGAACAAAATAGTCAATGTTAGCCTGGCAGATCTTAGAGGTGGAAATCGCC
CCAATACAGGGCCCTTATACACAGAGGCCGATCGAGTCATACAGAGAACAAATTCAATGCAGCAGTTGGAACAGTGGATTAAAATCCAGA
AGGGGAGGGGTCATGAAGAAGAAACCAGGGGAGTAATTTCTTACCAAACATTACCAAGAAATATGCCAAGTCACAGAGCCCAGATTATGG
CCCGCTACCCTGAAGGTTATAGAACACTCCCAAGAAACAGCAAGACAAGGCCTGAAAGTATCTGCAGTGTAACCCCTTCCACTCATGACA
AGACATTAGGACCCGGAGCGGAGGAGAAACGGAGGTCCATGAGAGATGACACAATGTGGCAGCTCTACGAATGGCAGCAGCGTCAGTTTT
ATAACAAACAGAGCACCCTCCCTCGACACAGTACTTTGAGTAGTCCCAAAACCATGGTAAATATTTCTGACCAGACAATGCACTCTATTC
CCACATCACCTTCCCACGGGTCAATAGCTGCTTATCAGGGATACTCCCCTCAACGAACTTACAGATCGGAAGTGTCTTCACCAATTCAGA
GAGGAGATGTGACAATAGACCGCAGACACAGGGCCCATCACCCTAAGCATGTCTATGTGCCTGACAGAAGGTCAGTGCCAGCTGGCCTGA
CTTTACAGTCTGTTAGTCCCCAGAGCCTCCAAGGGAAAACGCTGTCACAAGATGAAGGTAGAGGCACATTATACAAATACAGACCTGAAG
AAGTAGATATTGATGCCAAGTTAAGCCGATTATGTGAACAAGATAAAGTGGTGCATGCTCTGGAAGAGAAACTTCAGCAACTCCACAAGG
AGAAAAGCCATTCAGACAGTGGTGTTACAAAGGGATGATTTACAAAATGGACTGCTTAGTACGTGTCGAGAACTTTCTCGAGCCACTGCC
AGGAGCCCCTGGATCTTATCAGGCTCAGCCTAGATGAGCGAATTTATGTGAAAATGAGAAATGACCGAGAGCTTCGAGGCAGATTACATG
CTTATGATCAACATTTAAATATGATCTTGGGAGATGTGGAAGAAACTGTGACTACTATAGAAATTGATGAAGAAACATATGAAGAGATAT
ATAAATCAACGAAACGGAATATTCCAATGCTCTTTGTCCGGGGAGATGGCGTTGTCCTGGTTGCCCCTCCACTGAGAGTTGGCTGAAACA
AAGAATTTGTCCTGTATGGAAAACGGGAGACTTTGTACAGTGGCCTCTCTAAAAGTACAAAACATTCATAAGAGAAACCTGCATACATTT
TGATATTAAGAAATAATTCCGGGGATTCTTCCACTCCTGAAATGAGTTGATTTGCAGATAACTCACAACTTCTTAAGCTAAATGGTATTT
TCATTTTTCTCAAGCTCTCCAATAAATATGACCACCAAGATGCAGAACTCTTTCAGGACTTCTTTTGCTCCATTATTCTCACAGATACTT
ACTGATTTTTCTTTTCTTTAAATTGGTGTTTCCTTGTAGATTTTTTTAAGTGCGGTCTTCTGTCTTGTGAATTATTTAAAGTAAGCATGT
CTTACCTTCACTTAGCACACATTTGCAGTGCACCTACTGTGTTTGAGGCACCAGGTTTGAGTGCTGGGAACCAGAGTTTTATCAAAATGC
TTTCTGGGCCAGACATGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGATCACCTGAGGTCAGGCGTTTGAGA
CCAGCCTGGCCAACATGGTGAAACCCTTTCTCTACTGAAAATATAAAAATTAGCCAGGCGTGGTGGCGCATACTTGTAATCCCAGCTACT
CAGGAGGCTGAGGCAGTAGACGCTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCAAGATCACACCATTGCACTTCAACCTGGTCAACAG
AGCGAGACTCCGTGTCAAAAAAAAAAAAAAAAAAGTTTTCTGCCCTCAAGTCTTCTGGGGAGGCAGATGTTTAAACCAACAATTGCAGGC
AGTAAGATTAGTGCTGATAGAATCATGCACATGCAGGATGCCATAGGAGCATGGGGAAGAGCACCCAAATATGGGAGAAAGGGGCAGAGG
GACATTGTAAACATCAACCCTGCAGTAGAAGACAGAGCAAAGCATGATTTCTCTTTTCTCTGGCCTGATTTAATTCTAAGGTCAGACGTT
CAGCTTGATCATAACCTGTTTATAATTATGACTCAGACCATTTTTCCACTCTTGGATCATTGGCCATTAATGATGAGGGGTCTCAAACAA
CATGTCTCAGTGACACAGTAAAGCAGAAATTGGCTGAAAGCAAAGCTGTTTTTATTTCTAGCTTCAGTCAGCACATAATGCTTAAAACCT
AAAGAGGAAAGTAAAAGCGTGTTACAATCTCTCAAACTTTATCAAGACAGGGCTTAGAACCTGACATCCTCCGCTATGGTCATTCCATTT
TGAAATGTAGAAAATCCAACTTGTGGATGGTTTGTCTGTAAATGAGCTGAATGTGTGTGCGTGTTCATTATCAAGCACGATATGCTCACA
AATGCACAGTACTTTAAGCCTTGTGCAAGAAAGATGCTTTCAGTAAACATATTTAAAAGGTTTTATTTTCCTTACTAATGGTACATGCCC
CTGCAAGTTCATGGAGAAGAGAAAAACAAGTGTGGGTGAGCTGATGGAGGCTTCATCTTAGGTGAGGAGGCAGGAGAGACACCCTCCCTT
CACTTGTGCCATCCCCACGCTTTGTCCTTAAGCTGTAGTGGTCCCAGGAGATAACCTGTTTACAGCAGCCCATTCAGTATTGAAAAATGA
ACTCCCTCCTGCAGAATGTTAGAAGAAACAACCTCAAAGACCTCAGGCCGCCTGTGGTCATTAGTATGTGGCAGCAAGATTGAACCTGCC
TGCCTCCTACCTGTGTGAGCCTGTGGTGTGGGTGTGGTACCAAGGCCCTGGCTCTGGGCAGTCTGTTGGCTCCTGGTGTTCACTAAGGCG
TGGGGTGACAGGCCATCTGGCCTCGCTCTGCCAGTCTGCAGTTCTCCCCAGCACTGCATTCATTTTTAGTGGTTTCTGATAGTCACACTG
AATTCCTGGACACTTTCTTCTCTTCATTCTTAGTTATCTTTCTCCTTTTTCTCCTGGAACTGATAGTTTACACTAAAACTTTTGGCTGTG
AGGACTTGATTATACACATTTCTAAAACCCATGAACCTTAATATCTGACACTGTTACTCTCATATGCACACACAACTAAAACATACCAAC
CTACTTCATTTCCTAGCTGCTAAGATACAAGGGGAGGGACAATAAAAGGTTAACTGCAGAATAGCCACCTATGTGTCAGGAAATGGAGGG
AGGGGAGGCAATGTGTGAGTCCTTTTGGAGCTGGGACTCAATCCACAACAGAGACAGCTCAAGCAGGGCCCTGCCATGGTCCACACTGAG
GTTTCCTCTGCAGTGGTGCTGTCCACTGAGGGGTTATGGTGTGAGGGCCCCTGGGAGCCACGCCTTGGACTTCTGAGTCTGCAGAGCACT
CGGCTCCAGCCAGCTGGATGGCAGGTGGTCAGTGGAGCTGGTGACTGGTGGTTTCTGCAATGAGGTGTCAGATTAGCCTAAGGGAAGCCT
CTTCAGCAAGTATCATGCCTGGATCCCGGTCTTGGTTGTTTTATGAGAGGCCGATATGAATTGCCATTGCCTCCCACAAAGAAAAATGGA
CAAAATATGGGACCACATCTTTGAGATGAAATGTGCCCAAAATGAAAAGTAACTTGAGTATCCCAAGTTAAACTTAATCATTAGCTGCAA
ATGGACGATTTTCAAATTTCAAATAGTGATTTTTGAAGATTTGCCCAAACTAGAGTACTATCCCTCTTCACACTAAGAGGCAGAAAGTGG
TTTCACACACCCTTTTATTTAATCAGCTAAAGTGGGTGCGGTGACACACACCTGTAAACTCAACCACTAAGGAGACTGAGGCGGGAGGAT
TACTTGAGCCCAGGAGTTCGAGATCAGCCTGAGCAACATAACAAGACCCTGTCTCAAATAATACTTAGCTATTACCCATATTGCTTTTAG
CCTGCTGCCAGGAGGGGAGAAATGTTATTGTTTGAACAGATGTCAGATGTGAGTAATGCTCAGCTGTGTTCAATGTAGAAAATTAATAAA

>66183_66183_2_PLEKHA5-LSM3_PLEKHA5_chr12_19475516_ENST00000317589_LSM3_chr3_14223081_ENST00000306024_length(amino acids)=673AA_BP=
MAADLNLEWISLPRSWTYGITRGGRVFFINEEAKSTTWLHPVTGEAVVTGHRRQSTDLPTGWEEAYTFEGARYYINHNERKVTCKHPVTG
QPSQDNCIFVVNEQTVATMTSEEKKERPISMINEASNYNVTSDYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNAPVVRRGWLYKQD
STGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSEDHINRKYAFKAAHPNMRTYYFCTDTGKEMELWMKAMLDAALVQ
TEPVKRVDKITSENAPTKETNNIPNHRVLIKPEIQNNQKNKEMSKIEEKKALEAEKYGFQKDGQDRPLTKINSVKLNSLPSEYESGSACP
AQTVHYRPINLSSSENKIVNVSLADLRGGNRPNTGPLYTEADRVIQRTNSMQQLEQWIKIQKGRGHEEETRGVISYQTLPRNMPSHRAQI
MARYPEGYRTLPRNSKTRPESICSVTPSTHDKTLGPGAEEKRRSMRDDTMWQLYEWQQRQFYNKQSTLPRHSTLSSPKTMVNISDQTMHS
IPTSPSHGSIAAYQGYSPQRTYRSEVSSPIQRGDVTIDRRHRAHHPKHVYVPDRRSVPAGLTLQSVSPQSLQGKTLSQDEGRGTLYKYRP

--------------------------------------------------------------
>66183_66183_3_PLEKHA5-LSM3_PLEKHA5_chr12_19475516_ENST00000355397_LSM3_chr3_14223081_ENST00000306024_length(transcript)=5603nt_BP=2334nt
GCGCTCCCTTCGCTCGCTCGTTCCCTCCTCCCTCGGCAGCCGCGGCGGCAGCAGGAGAAGGCGGCGGCGGCGGCTAGGGATCAGACATGG
CGGCGGATCTGAACCTGGAGTGGATCTCCCTGCCCCGGTCCTGGACTTACGGGATCACCAGGGGCGGCCGAGTCTTCTTCATCAACGAGG
AGGCCAAGAGCACCACCTGGCTGCACCCCGTCACCGGCGAGGCGGTGGTCACCGGACACCGGCGGCAGAGCACAGATTTGCCTACTGGCT
GGGAAGAAGCATATACTTTTGAAGGTGCAAGATACTATATAAACCATAATGAAAGGAAAGTGACCTGCAAACATCCAGTCACAGGACAAC
CATCACAGGACAATTGTATTTTTGTAGTGAATGAACAGACTGTTGCAACCATGACATCTGAAGAAAAGAAGGAACGGCCAATAAGTATGA
TAAATGAAGCTTCTAACTATAACGTGACTTCAGATTATGCAGTGCATCCAATGAGCCCTGTAGGCAGAACTTCACGAGCTTCAAAAAAAG
TTCATAATTTTGGAAAGAGGTCAAATTCAATTAAAAGGAATCCTAATGCACCGGTTGTCAGACGAGGTTGGCTTTATAAACAGGACAGTA
CTGGCATGAAATTGTGGAAGAAACGCTGGTTTGTGCTTTCTGACCTTTGCCTCTTTTATTATAGAGATGAGAAAGAAGAGGGTATCCTGG
GAAGCATACTGTTACCTAGTTTTCAGATAGCTTTGCTTACCTCTGAAGATCACATTAATCGCAAATATGCTTTTAAGGCAGCCCATCCAA
ACATGCGGACCTATTATTTCTGCACTGATACAGGAAAGGAAATGGAGTTGTGGATGAAAGCCATGTTAGATGCTGCCCTAGTACAGACAG
AACCTGTGAAAAGAGTGGACAAGATTACATCTGAAAATGCACCAACTAAAGAAACCAATAACATTCCCAACCATAGAGTGCTAATTAAAC
CAGAGATCCAAAACAATCAAAAAAACAAGGAAATGAGCAAAATTGAAGAAAAAAAGGCATTAGAAGCTGAAAAATATGGATTTCAGAAGG
ATGGTCAAGATAGACCCTTAACAAAAATTAATAGTGTAAAGCTGAATTCTCTGCCATCTGAATATGAGAGTGGGTCAGCATGCCCTGCTC
AGACTGTGCACTACAGACCAATCAACTTGAGCAGTTCAGAGAACAAAATAGTCAATGTTAGCCTGGCAGATCTTAGAGGTGGAAATCGCC
CCAATACAGGGCCCTTATACACAGAGGCCGATCGAGTCATACAGAGAACAAATTCAATGCAGCAGTTGGAACAGTGGATTAAAATCCAGA
AGGGGAGGGGTCATGAAGAAGAAACCAGGGGAGTAATTTCTTACCAAACATTACCAAGAAATATGCCAAGTCACAGAGCCCAGATTATGG
CCCGCTACCCTGAAGGTTATAGAACACTCCCAAGAAACAGCAAGACAAGGCCTGAAAGTATCTGCAGTGTAACCCCTTCCACTCATGACA
AGACATTAGGACCCGGAGCGGAGGAGAAACGGAGGTCCATGAGAGATGACACAATGTGGCAGCTCTACGAATGGCAGCAGCGTCAGTTTT
ATAACAAACAGAGCACCCTCCCTCGACACAGTACTTTGAGTAGTCCCAAAACCATGGTAAATATTTCTGACCAGACAATGCACTCTATTC
CCACATCACCTTCCCACGGGTCAATAGCTGCTTATCAGGGATACTCCCCTCAACGAACTTACAGATCGGAAGTGTCTTCACCAATTCAGA
GAGGAGATGTGACAATAGACCGCAGACACAGGGCCCATCACCCTAAGCATGTCTATGTGCCTGACAGAAGGTCAGTGCCAGCTGGCCTGA
CTTTACAGTCTGTTAGTCCCCAGAGCCTCCAAGGGAAAACGCCAGAGGAGCTTACGCTGCTGCTAATAAAGCTGAGACGGCAGCAAGCCG
AACTGAGTAGTATCCGGGAGCATACGTTAGCACAGCTCATGCAGCTAAAGCTTGAGGCCCACAGCCCAAAGAATGAAATTCTTTCACATC
ATCTCCAAAGGAACACCATATATTTGGATCATCAGCTGTCACAAGATGAAGGTAGAGGCACATTATACAAATACAGACCTGAAGAAGTAG
ATATTGATGCCAAGTTAAGCCGATTATGTGAACAAGATAAAGTGGTGCATGCTCTGGAAGAGAAACTTCAGCAACTCCACAAGGAGAAAA
GCCATTCAGACAGTGGTGTTACAAAGGGATGATTTACAAAATGGACTGCTTAGTACGTGTCGAGAACTTTCTCGAGCCACTGCCAGGAGC
CCCTGGATCTTATCAGGCTCAGCCTAGATGAGCGAATTTATGTGAAAATGAGAAATGACCGAGAGCTTCGAGGCAGATTACATGCTTATG
ATCAACATTTAAATATGATCTTGGGAGATGTGGAAGAAACTGTGACTACTATAGAAATTGATGAAGAAACATATGAAGAGATATATAAAT
CAACGAAACGGAATATTCCAATGCTCTTTGTCCGGGGAGATGGCGTTGTCCTGGTTGCCCCTCCACTGAGAGTTGGCTGAAACAAAGAAT
TTGTCCTGTATGGAAAACGGGAGACTTTGTACAGTGGCCTCTCTAAAAGTACAAAACATTCATAAGAGAAACCTGCATACATTTTGATAT
TAAGAAATAATTCCGGGGATTCTTCCACTCCTGAAATGAGTTGATTTGCAGATAACTCACAACTTCTTAAGCTAAATGGTATTTTCATTT
TTCTCAAGCTCTCCAATAAATATGACCACCAAGATGCAGAACTCTTTCAGGACTTCTTTTGCTCCATTATTCTCACAGATACTTACTGAT
TTTTCTTTTCTTTAAATTGGTGTTTCCTTGTAGATTTTTTTAAGTGCGGTCTTCTGTCTTGTGAATTATTTAAAGTAAGCATGTCTTACC
TTCACTTAGCACACATTTGCAGTGCACCTACTGTGTTTGAGGCACCAGGTTTGAGTGCTGGGAACCAGAGTTTTATCAAAATGCTTTCTG
GGCCAGACATGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGATCACCTGAGGTCAGGCGTTTGAGACCAGCC
TGGCCAACATGGTGAAACCCTTTCTCTACTGAAAATATAAAAATTAGCCAGGCGTGGTGGCGCATACTTGTAATCCCAGCTACTCAGGAG
GCTGAGGCAGTAGACGCTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCAAGATCACACCATTGCACTTCAACCTGGTCAACAGAGCGAG
ACTCCGTGTCAAAAAAAAAAAAAAAAAAGTTTTCTGCCCTCAAGTCTTCTGGGGAGGCAGATGTTTAAACCAACAATTGCAGGCAGTAAG
ATTAGTGCTGATAGAATCATGCACATGCAGGATGCCATAGGAGCATGGGGAAGAGCACCCAAATATGGGAGAAAGGGGCAGAGGGACATT
GTAAACATCAACCCTGCAGTAGAAGACAGAGCAAAGCATGATTTCTCTTTTCTCTGGCCTGATTTAATTCTAAGGTCAGACGTTCAGCTT
GATCATAACCTGTTTATAATTATGACTCAGACCATTTTTCCACTCTTGGATCATTGGCCATTAATGATGAGGGGTCTCAAACAACATGTC
TCAGTGACACAGTAAAGCAGAAATTGGCTGAAAGCAAAGCTGTTTTTATTTCTAGCTTCAGTCAGCACATAATGCTTAAAACCTAAAGAG
GAAAGTAAAAGCGTGTTACAATCTCTCAAACTTTATCAAGACAGGGCTTAGAACCTGACATCCTCCGCTATGGTCATTCCATTTTGAAAT
GTAGAAAATCCAACTTGTGGATGGTTTGTCTGTAAATGAGCTGAATGTGTGTGCGTGTTCATTATCAAGCACGATATGCTCACAAATGCA
CAGTACTTTAAGCCTTGTGCAAGAAAGATGCTTTCAGTAAACATATTTAAAAGGTTTTATTTTCCTTACTAATGGTACATGCCCCTGCAA
GTTCATGGAGAAGAGAAAAACAAGTGTGGGTGAGCTGATGGAGGCTTCATCTTAGGTGAGGAGGCAGGAGAGACACCCTCCCTTCACTTG
TGCCATCCCCACGCTTTGTCCTTAAGCTGTAGTGGTCCCAGGAGATAACCTGTTTACAGCAGCCCATTCAGTATTGAAAAATGAACTCCC
TCCTGCAGAATGTTAGAAGAAACAACCTCAAAGACCTCAGGCCGCCTGTGGTCATTAGTATGTGGCAGCAAGATTGAACCTGCCTGCCTC
CTACCTGTGTGAGCCTGTGGTGTGGGTGTGGTACCAAGGCCCTGGCTCTGGGCAGTCTGTTGGCTCCTGGTGTTCACTAAGGCGTGGGGT
GACAGGCCATCTGGCCTCGCTCTGCCAGTCTGCAGTTCTCCCCAGCACTGCATTCATTTTTAGTGGTTTCTGATAGTCACACTGAATTCC
TGGACACTTTCTTCTCTTCATTCTTAGTTATCTTTCTCCTTTTTCTCCTGGAACTGATAGTTTACACTAAAACTTTTGGCTGTGAGGACT
TGATTATACACATTTCTAAAACCCATGAACCTTAATATCTGACACTGTTACTCTCATATGCACACACAACTAAAACATACCAACCTACTT
CATTTCCTAGCTGCTAAGATACAAGGGGAGGGACAATAAAAGGTTAACTGCAGAATAGCCACCTATGTGTCAGGAAATGGAGGGAGGGGA
GGCAATGTGTGAGTCCTTTTGGAGCTGGGACTCAATCCACAACAGAGACAGCTCAAGCAGGGCCCTGCCATGGTCCACACTGAGGTTTCC
TCTGCAGTGGTGCTGTCCACTGAGGGGTTATGGTGTGAGGGCCCCTGGGAGCCACGCCTTGGACTTCTGAGTCTGCAGAGCACTCGGCTC
CAGCCAGCTGGATGGCAGGTGGTCAGTGGAGCTGGTGACTGGTGGTTTCTGCAATGAGGTGTCAGATTAGCCTAAGGGAAGCCTCTTCAG
CAAGTATCATGCCTGGATCCCGGTCTTGGTTGTTTTATGAGAGGCCGATATGAATTGCCATTGCCTCCCACAAAGAAAAATGGACAAAAT
ATGGGACCACATCTTTGAGATGAAATGTGCCCAAAATGAAAAGTAACTTGAGTATCCCAAGTTAAACTTAATCATTAGCTGCAAATGGAC
GATTTTCAAATTTCAAATAGTGATTTTTGAAGATTTGCCCAAACTAGAGTACTATCCCTCTTCACACTAAGAGGCAGAAAGTGGTTTCAC
ACACCCTTTTATTTAATCAGCTAAAGTGGGTGCGGTGACACACACCTGTAAACTCAACCACTAAGGAGACTGAGGCGGGAGGATTACTTG
AGCCCAGGAGTTCGAGATCAGCCTGAGCAACATAACAAGACCCTGTCTCAAATAATACTTAGCTATTACCCATATTGCTTTTAGCCTGCT
GCCAGGAGGGGAGAAATGTTATTGTTTGAACAGATGTCAGATGTGAGTAATGCTCAGCTGTGTTCAATGTAGAAAATTAATAAAAGTTCC

>66183_66183_3_PLEKHA5-LSM3_PLEKHA5_chr12_19475516_ENST00000355397_LSM3_chr3_14223081_ENST00000306024_length(amino acids)=731AA_BP=
MAADLNLEWISLPRSWTYGITRGGRVFFINEEAKSTTWLHPVTGEAVVTGHRRQSTDLPTGWEEAYTFEGARYYINHNERKVTCKHPVTG
QPSQDNCIFVVNEQTVATMTSEEKKERPISMINEASNYNVTSDYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNAPVVRRGWLYKQD
STGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSEDHINRKYAFKAAHPNMRTYYFCTDTGKEMELWMKAMLDAALVQ
TEPVKRVDKITSENAPTKETNNIPNHRVLIKPEIQNNQKNKEMSKIEEKKALEAEKYGFQKDGQDRPLTKINSVKLNSLPSEYESGSACP
AQTVHYRPINLSSSENKIVNVSLADLRGGNRPNTGPLYTEADRVIQRTNSMQQLEQWIKIQKGRGHEEETRGVISYQTLPRNMPSHRAQI
MARYPEGYRTLPRNSKTRPESICSVTPSTHDKTLGPGAEEKRRSMRDDTMWQLYEWQQRQFYNKQSTLPRHSTLSSPKTMVNISDQTMHS
IPTSPSHGSIAAYQGYSPQRTYRSEVSSPIQRGDVTIDRRHRAHHPKHVYVPDRRSVPAGLTLQSVSPQSLQGKTPEELTLLLIKLRRQQ
AELSSIREHTLAQLMQLKLEAHSPKNEILSHHLQRNTIYLDHQLSQDEGRGTLYKYRPEEVDIDAKLSRLCEQDKVVHALEEKLQQLHKE

--------------------------------------------------------------
>66183_66183_4_PLEKHA5-LSM3_PLEKHA5_chr12_19475516_ENST00000359180_LSM3_chr3_14223081_ENST00000306024_length(transcript)=5429nt_BP=2160nt
GCGCTCCCTTCGCTCGCTCGTTCCCTCCTCCCTCGGCAGCCGCGGCGGCAGCAGGAGAAGGCGGCGGCGGCGGCTAGGGATCAGACATGG
CGGCGGATCTGAACCTGGAGTGGATCTCCCTGCCCCGGTCCTGGACTTACGGGATCACCAGGGGCGGCCGAGTCTTCTTCATCAACGAGG
AGGCCAAGAGCACCACCTGGCTGCACCCCGTCACCGGCGAGGCGGTGGTCACCGGACACCGGCGGCAGAGCACAGATTTGCCTACTGGCT
GGGAAGAAGCATATACTTTTGAAGGTGCAAGATACTATATAAACCATAATGAAAGGAAAGTGACCTGCAAACATCCAGTCACAGGACAAC
CATCACAGGACAATTGTATTTTTGTAGTGAATGAACAGACTGTTGCAACCATGACATCTGAAGAAAAGAAGGAACGGCCAATAAGTATGA
TAAATGAAGCTTCTAACTATAACGTGACTTCAGATTATGCAGTGCATCCAATGAGCCCTGTAGGCAGAACTTCACGAGCTTCAAAAAAAG
TTCATAATTTTGGAAAGAGGTCAAATTCAATTAAAAGGAATCCTAATGCACCGGTTGTCAGACGAGGTTGGCTTTATAAACAGGACAGTA
CTGGCATGAAATTGTGGAAGAAACGCTGGTTTGTGCTTTCTGACCTTTGCCTCTTTTATTATAGAGATGAGAAAGAAGAGGGTATCCTGG
GAAGCATACTGTTACCTAGTTTTCAGATAGCTTTGCTTACCTCTGAAGATCACATTAATCGCAAATATGCTTTTAAGGCAGCCCATCCAA
ACATGCGGACCTATTATTTCTGCACTGATACAGGAAAGGAAATGGAGTTGTGGATGAAAGCCATGTTAGATGCTGCCCTAGTACAGACAG
AACCTGTGAAAAGAGTGGACAAGATTACATCTGAAAATGCACCAACTAAAGAAACCAATAACATTCCCAACCATAGAGTGCTAATTAAAC
CAGAGATCCAAAACAATCAAAAAAACAAGGAAATGAGCAAAATTGAAGAAAAAAAGGCATTAGAAGCTGAAAAATATGGATTTCAGAAGG
ATGGTCAAGATAGACCCTTAACAAAAATTAATAGTGTAAAGCTGAATTCTCTGCCATCTGAATATGAGAGTGGGTCAGCATGCCCTGCTC
AGACTGTGCACTACAGACCAATCAACTTGAGCAGTTCAGAGAACAAAATAGTCAATGTTAGCCTGGCAGATCTTAGAGGTGGAAATCGCC
CCAATACAGGGCCCTTATACACAGAGGCCGATCGAGTCATACAGAGAACAAATTCAATGCAGCAGTTGGAACAGTGGATTAAAATCCAGA
AGGGGAGGGGTCATGAAGAAGAAACCAGGGGAGTAATTTCTTACCAAACATTACCAAGAAATATGCCAAGTCACAGAGCCCAGATTATGG
CCCGCTACCCTGAAGGTTATAGAACACTCCCAAGAAACAGCAAGACAAGGCCTGAAAGTATCTGCAGTGTAACCCCTTCCACTCATGACA
AGACATTAGGACCCGGAGCGGAGGAGAAACGGAGGTCCATGAGAGATGACACAATGTGGCAGCTCTACGAATGGCAGCAGCGTCAGTTTT
ATAACAAACAGAGCACCCTCCCTCGACACAGTACTTTGAGTAGTCCCAAAACCATGGTAAATATTTCTGACCAGACAATGCACTCTATTC
CCACATCACCTTCCCACGGGTCAATAGCTGCTTATCAGGGATACTCCCCTCAACGAACTTACAGATCGGAAGTGTCTTCACCAATTCAGA
GAGGAGATGTGACAATAGACCGCAGACACAGGGCCCATCACCCTAAGCATGTCTATGTGCCTGACAGAAGGTCAGTGCCAGCTGGCCTGA
CTTTACAGTCTGTTAGTCCCCAGAGCCTCCAAGGGAAAACGCTGTCACAAGATGAAGGTAGAGGCACATTATACAAATACAGACCTGAAG
AAGTAGATATTGATGCCAAGTTAAGCCGATTATGTGAACAAGATAAAGTGGTGCATGCTCTGGAAGAGAAACTTCAGCAACTCCACAAGG
AGAAAAGCCATTCAGACAGTGGTGTTACAAAGGGATGATTTACAAAATGGACTGCTTAGTACGTGTCGAGAACTTTCTCGAGCCACTGCC
AGGAGCCCCTGGATCTTATCAGGCTCAGCCTAGATGAGCGAATTTATGTGAAAATGAGAAATGACCGAGAGCTTCGAGGCAGATTACATG
CTTATGATCAACATTTAAATATGATCTTGGGAGATGTGGAAGAAACTGTGACTACTATAGAAATTGATGAAGAAACATATGAAGAGATAT
ATAAATCAACGAAACGGAATATTCCAATGCTCTTTGTCCGGGGAGATGGCGTTGTCCTGGTTGCCCCTCCACTGAGAGTTGGCTGAAACA
AAGAATTTGTCCTGTATGGAAAACGGGAGACTTTGTACAGTGGCCTCTCTAAAAGTACAAAACATTCATAAGAGAAACCTGCATACATTT
TGATATTAAGAAATAATTCCGGGGATTCTTCCACTCCTGAAATGAGTTGATTTGCAGATAACTCACAACTTCTTAAGCTAAATGGTATTT
TCATTTTTCTCAAGCTCTCCAATAAATATGACCACCAAGATGCAGAACTCTTTCAGGACTTCTTTTGCTCCATTATTCTCACAGATACTT
ACTGATTTTTCTTTTCTTTAAATTGGTGTTTCCTTGTAGATTTTTTTAAGTGCGGTCTTCTGTCTTGTGAATTATTTAAAGTAAGCATGT
CTTACCTTCACTTAGCACACATTTGCAGTGCACCTACTGTGTTTGAGGCACCAGGTTTGAGTGCTGGGAACCAGAGTTTTATCAAAATGC
TTTCTGGGCCAGACATGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGATCACCTGAGGTCAGGCGTTTGAGA
CCAGCCTGGCCAACATGGTGAAACCCTTTCTCTACTGAAAATATAAAAATTAGCCAGGCGTGGTGGCGCATACTTGTAATCCCAGCTACT
CAGGAGGCTGAGGCAGTAGACGCTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCAAGATCACACCATTGCACTTCAACCTGGTCAACAG
AGCGAGACTCCGTGTCAAAAAAAAAAAAAAAAAAGTTTTCTGCCCTCAAGTCTTCTGGGGAGGCAGATGTTTAAACCAACAATTGCAGGC
AGTAAGATTAGTGCTGATAGAATCATGCACATGCAGGATGCCATAGGAGCATGGGGAAGAGCACCCAAATATGGGAGAAAGGGGCAGAGG
GACATTGTAAACATCAACCCTGCAGTAGAAGACAGAGCAAAGCATGATTTCTCTTTTCTCTGGCCTGATTTAATTCTAAGGTCAGACGTT
CAGCTTGATCATAACCTGTTTATAATTATGACTCAGACCATTTTTCCACTCTTGGATCATTGGCCATTAATGATGAGGGGTCTCAAACAA
CATGTCTCAGTGACACAGTAAAGCAGAAATTGGCTGAAAGCAAAGCTGTTTTTATTTCTAGCTTCAGTCAGCACATAATGCTTAAAACCT
AAAGAGGAAAGTAAAAGCGTGTTACAATCTCTCAAACTTTATCAAGACAGGGCTTAGAACCTGACATCCTCCGCTATGGTCATTCCATTT
TGAAATGTAGAAAATCCAACTTGTGGATGGTTTGTCTGTAAATGAGCTGAATGTGTGTGCGTGTTCATTATCAAGCACGATATGCTCACA
AATGCACAGTACTTTAAGCCTTGTGCAAGAAAGATGCTTTCAGTAAACATATTTAAAAGGTTTTATTTTCCTTACTAATGGTACATGCCC
CTGCAAGTTCATGGAGAAGAGAAAAACAAGTGTGGGTGAGCTGATGGAGGCTTCATCTTAGGTGAGGAGGCAGGAGAGACACCCTCCCTT
CACTTGTGCCATCCCCACGCTTTGTCCTTAAGCTGTAGTGGTCCCAGGAGATAACCTGTTTACAGCAGCCCATTCAGTATTGAAAAATGA
ACTCCCTCCTGCAGAATGTTAGAAGAAACAACCTCAAAGACCTCAGGCCGCCTGTGGTCATTAGTATGTGGCAGCAAGATTGAACCTGCC
TGCCTCCTACCTGTGTGAGCCTGTGGTGTGGGTGTGGTACCAAGGCCCTGGCTCTGGGCAGTCTGTTGGCTCCTGGTGTTCACTAAGGCG
TGGGGTGACAGGCCATCTGGCCTCGCTCTGCCAGTCTGCAGTTCTCCCCAGCACTGCATTCATTTTTAGTGGTTTCTGATAGTCACACTG
AATTCCTGGACACTTTCTTCTCTTCATTCTTAGTTATCTTTCTCCTTTTTCTCCTGGAACTGATAGTTTACACTAAAACTTTTGGCTGTG
AGGACTTGATTATACACATTTCTAAAACCCATGAACCTTAATATCTGACACTGTTACTCTCATATGCACACACAACTAAAACATACCAAC
CTACTTCATTTCCTAGCTGCTAAGATACAAGGGGAGGGACAATAAAAGGTTAACTGCAGAATAGCCACCTATGTGTCAGGAAATGGAGGG
AGGGGAGGCAATGTGTGAGTCCTTTTGGAGCTGGGACTCAATCCACAACAGAGACAGCTCAAGCAGGGCCCTGCCATGGTCCACACTGAG
GTTTCCTCTGCAGTGGTGCTGTCCACTGAGGGGTTATGGTGTGAGGGCCCCTGGGAGCCACGCCTTGGACTTCTGAGTCTGCAGAGCACT
CGGCTCCAGCCAGCTGGATGGCAGGTGGTCAGTGGAGCTGGTGACTGGTGGTTTCTGCAATGAGGTGTCAGATTAGCCTAAGGGAAGCCT
CTTCAGCAAGTATCATGCCTGGATCCCGGTCTTGGTTGTTTTATGAGAGGCCGATATGAATTGCCATTGCCTCCCACAAAGAAAAATGGA
CAAAATATGGGACCACATCTTTGAGATGAAATGTGCCCAAAATGAAAAGTAACTTGAGTATCCCAAGTTAAACTTAATCATTAGCTGCAA
ATGGACGATTTTCAAATTTCAAATAGTGATTTTTGAAGATTTGCCCAAACTAGAGTACTATCCCTCTTCACACTAAGAGGCAGAAAGTGG
TTTCACACACCCTTTTATTTAATCAGCTAAAGTGGGTGCGGTGACACACACCTGTAAACTCAACCACTAAGGAGACTGAGGCGGGAGGAT
TACTTGAGCCCAGGAGTTCGAGATCAGCCTGAGCAACATAACAAGACCCTGTCTCAAATAATACTTAGCTATTACCCATATTGCTTTTAG
CCTGCTGCCAGGAGGGGAGAAATGTTATTGTTTGAACAGATGTCAGATGTGAGTAATGCTCAGCTGTGTTCAATGTAGAAAATTAATAAA

>66183_66183_4_PLEKHA5-LSM3_PLEKHA5_chr12_19475516_ENST00000359180_LSM3_chr3_14223081_ENST00000306024_length(amino acids)=673AA_BP=
MAADLNLEWISLPRSWTYGITRGGRVFFINEEAKSTTWLHPVTGEAVVTGHRRQSTDLPTGWEEAYTFEGARYYINHNERKVTCKHPVTG
QPSQDNCIFVVNEQTVATMTSEEKKERPISMINEASNYNVTSDYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNAPVVRRGWLYKQD
STGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSEDHINRKYAFKAAHPNMRTYYFCTDTGKEMELWMKAMLDAALVQ
TEPVKRVDKITSENAPTKETNNIPNHRVLIKPEIQNNQKNKEMSKIEEKKALEAEKYGFQKDGQDRPLTKINSVKLNSLPSEYESGSACP
AQTVHYRPINLSSSENKIVNVSLADLRGGNRPNTGPLYTEADRVIQRTNSMQQLEQWIKIQKGRGHEEETRGVISYQTLPRNMPSHRAQI
MARYPEGYRTLPRNSKTRPESICSVTPSTHDKTLGPGAEEKRRSMRDDTMWQLYEWQQRQFYNKQSTLPRHSTLSSPKTMVNISDQTMHS
IPTSPSHGSIAAYQGYSPQRTYRSEVSSPIQRGDVTIDRRHRAHHPKHVYVPDRRSVPAGLTLQSVSPQSLQGKTLSQDEGRGTLYKYRP

--------------------------------------------------------------
>66183_66183_5_PLEKHA5-LSM3_PLEKHA5_chr12_19475516_ENST00000424268_LSM3_chr3_14223081_ENST00000306024_length(transcript)=5352nt_BP=2083nt
AAAAGAGATCACGGTGTGCCCCTTTGTCATCGTTCTGTCAGGAAGCATGTAATTTGTCTTTAGAAACCAGAAGCCTGAGACAAAGAAAAG
AACACAGATTTTTAGCAAAAGGCTATTTGCCATAATGAAAGGAAAGTGACCTGCAAACATCCAGTCACAGGACAACCATCACAGGACAAT
TGTATTTTTGTAGTGAATGAACAGACTGTTGCAACCATGACATCTGAAGAAAAGAAGGAACGGCCAATAAGTATGATAAATGAAGCTTCT
AACTATAACGTGACTTCAGATTATGCAGTGCATCCAATGAGCCCTGTAGGCAGAACTTCACGAGCTTCAAAAAAAGTTCATAATTTTGGA
AAGAGGTCAAATTCAATTAAAAGGAATCCTAATGCACCGGTTGTCAGACGAGGTTGGCTTTATAAACAGGACAGTACTGGCATGAAATTG
TGGAAGAAACGCTGGTTTGTGCTTTCTGACCTTTGCCTCTTTTATTATAGAGATGAGAAAGAAGAGGGTATCCTGGGAAGCATACTGTTA
CCTAGTTTTCAGATAGCTTTGCTTACCTCTGAAGATCACATTAATCGCAAATATGCTTTTAAGGCAGCCCATCCAAACATGCGGACCTAT
TATTTCTGCACTGATACAGGAAAGGAAATGGAGTTGTGGATGAAAGCCATGTTAGATGCTGCCCTAGTACAGACAGAACCTGTGAAAAGA
GTGGACAAGATTACATCTGAAAATGCACCAACTAAAGAAACCAATAACATTCCCAACCATAGAGTGCTAATTAAACCAGAGATCCAAAAC
AATCAAAAAAACAAGGAAATGAGCAAAATTGAAGAAAAAAAGGCATTAGAAGCTGAAAAATATGGATTTCAGAAGGATGGTCAAGATAGA
CCCTTAACAAAAATTAATAGTGTAAAGCTGAATTCTCTGCCATCTGAATATGAGAGTGGGTCAGCATGCCCTGCTCAGACTGTGCACTAC
AGACCAATCAACTTGAGCAGTTCAGAGAACAAAATAGTCAATGTTAGCCTGGCAGATCTTAGAGGTGGAAATCGCCCCAATACAGGGCCC
TTATACACAGAGGCCGATCGAGTCATACAGAGAACAAATTCAATGCAGCAGTTGGAACAGTGGATTAAAATCCAGAAGGGGAGGGGTCAT
GAAGAAGAAACCAGGGGAGTAATTTCTTACCAAACATTACCAAGAAATATGCCAAGTCACAGAGCCCAGATTATGGCCCGCTACCCTGAA
GGTTATAGAACACTCCCAAGAAACAGCAAGACAAGGCCTGAAAGTATCTGCAGTGTAACCCCTTCCACTCATGACAAGACATTAGGACCC
GGAGCGGAGGAGAAACGGAGGTCCATGAGAGATGACACAATGTGGCAGCTCTACGAATGGCAGCAGCGTCAGTTTTATAACAAACAGAGC
ACCCTCCCTCGACACAGTACTTTGAGTAGTCCCAAAACCATGGTAAATATTTCTGACCAGACAATGCACTCTATTCCCACATCACCTTCC
CACGGGTCAATAGCTGCTTATCAGGGATACTCCCCTCAACGAACTTACAGATCGGAAGTGTCTTCACCAATTCAGAGAGGAGATGTGACA
ATAGACCGCAGACACAGGGCCCATCACCCTAAGCATGTCTATGTGCCTGACAGAAGGTCAGTGCCAGCTGGCCTGACTTTACAGTCTGTT
AGTCCCCAGAGCCTCCAAGGGAAAACGATGAAAGAAAATGAACCTATTATCACCATGGTTCACACAATGATTGAGAACTCGGCGCTAAGA
CCCCAACTGTACCAGCAATTCTTAAGACAGAAGAGCAAGATAAGTCTATATTGTCTGTCACAAGATGAAGGTAGAGGCACATTATACAAA
TACAGACCTGAAGAAGTAGATATTGATGCCAAGTTAAGCCGATTATGTGAACAAGATAAAGTGGTGCATGCTCTGGAAGAGAAACTTCAG
CAACTCCACAAGGAGAAAAGCCATTCAGACAGTGGTGTTACAAAGGGATGATTTACAAAATGGACTGCTTAGTACGTGTCGAGAACTTTC
TCGAGCCACTGCCAGGAGCCCCTGGATCTTATCAGGCTCAGCCTAGATGAGCGAATTTATGTGAAAATGAGAAATGACCGAGAGCTTCGA
GGCAGATTACATGCTTATGATCAACATTTAAATATGATCTTGGGAGATGTGGAAGAAACTGTGACTACTATAGAAATTGATGAAGAAACA
TATGAAGAGATATATAAATCAACGAAACGGAATATTCCAATGCTCTTTGTCCGGGGAGATGGCGTTGTCCTGGTTGCCCCTCCACTGAGA
GTTGGCTGAAACAAAGAATTTGTCCTGTATGGAAAACGGGAGACTTTGTACAGTGGCCTCTCTAAAAGTACAAAACATTCATAAGAGAAA
CCTGCATACATTTTGATATTAAGAAATAATTCCGGGGATTCTTCCACTCCTGAAATGAGTTGATTTGCAGATAACTCACAACTTCTTAAG
CTAAATGGTATTTTCATTTTTCTCAAGCTCTCCAATAAATATGACCACCAAGATGCAGAACTCTTTCAGGACTTCTTTTGCTCCATTATT
CTCACAGATACTTACTGATTTTTCTTTTCTTTAAATTGGTGTTTCCTTGTAGATTTTTTTAAGTGCGGTCTTCTGTCTTGTGAATTATTT
AAAGTAAGCATGTCTTACCTTCACTTAGCACACATTTGCAGTGCACCTACTGTGTTTGAGGCACCAGGTTTGAGTGCTGGGAACCAGAGT
TTTATCAAAATGCTTTCTGGGCCAGACATGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGATCACCTGAGGT
CAGGCGTTTGAGACCAGCCTGGCCAACATGGTGAAACCCTTTCTCTACTGAAAATATAAAAATTAGCCAGGCGTGGTGGCGCATACTTGT
AATCCCAGCTACTCAGGAGGCTGAGGCAGTAGACGCTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCAAGATCACACCATTGCACTTCA
ACCTGGTCAACAGAGCGAGACTCCGTGTCAAAAAAAAAAAAAAAAAAGTTTTCTGCCCTCAAGTCTTCTGGGGAGGCAGATGTTTAAACC
AACAATTGCAGGCAGTAAGATTAGTGCTGATAGAATCATGCACATGCAGGATGCCATAGGAGCATGGGGAAGAGCACCCAAATATGGGAG
AAAGGGGCAGAGGGACATTGTAAACATCAACCCTGCAGTAGAAGACAGAGCAAAGCATGATTTCTCTTTTCTCTGGCCTGATTTAATTCT
AAGGTCAGACGTTCAGCTTGATCATAACCTGTTTATAATTATGACTCAGACCATTTTTCCACTCTTGGATCATTGGCCATTAATGATGAG
GGGTCTCAAACAACATGTCTCAGTGACACAGTAAAGCAGAAATTGGCTGAAAGCAAAGCTGTTTTTATTTCTAGCTTCAGTCAGCACATA
ATGCTTAAAACCTAAAGAGGAAAGTAAAAGCGTGTTACAATCTCTCAAACTTTATCAAGACAGGGCTTAGAACCTGACATCCTCCGCTAT
GGTCATTCCATTTTGAAATGTAGAAAATCCAACTTGTGGATGGTTTGTCTGTAAATGAGCTGAATGTGTGTGCGTGTTCATTATCAAGCA
CGATATGCTCACAAATGCACAGTACTTTAAGCCTTGTGCAAGAAAGATGCTTTCAGTAAACATATTTAAAAGGTTTTATTTTCCTTACTA
ATGGTACATGCCCCTGCAAGTTCATGGAGAAGAGAAAAACAAGTGTGGGTGAGCTGATGGAGGCTTCATCTTAGGTGAGGAGGCAGGAGA
GACACCCTCCCTTCACTTGTGCCATCCCCACGCTTTGTCCTTAAGCTGTAGTGGTCCCAGGAGATAACCTGTTTACAGCAGCCCATTCAG
TATTGAAAAATGAACTCCCTCCTGCAGAATGTTAGAAGAAACAACCTCAAAGACCTCAGGCCGCCTGTGGTCATTAGTATGTGGCAGCAA
GATTGAACCTGCCTGCCTCCTACCTGTGTGAGCCTGTGGTGTGGGTGTGGTACCAAGGCCCTGGCTCTGGGCAGTCTGTTGGCTCCTGGT
GTTCACTAAGGCGTGGGGTGACAGGCCATCTGGCCTCGCTCTGCCAGTCTGCAGTTCTCCCCAGCACTGCATTCATTTTTAGTGGTTTCT
GATAGTCACACTGAATTCCTGGACACTTTCTTCTCTTCATTCTTAGTTATCTTTCTCCTTTTTCTCCTGGAACTGATAGTTTACACTAAA
ACTTTTGGCTGTGAGGACTTGATTATACACATTTCTAAAACCCATGAACCTTAATATCTGACACTGTTACTCTCATATGCACACACAACT
AAAACATACCAACCTACTTCATTTCCTAGCTGCTAAGATACAAGGGGAGGGACAATAAAAGGTTAACTGCAGAATAGCCACCTATGTGTC
AGGAAATGGAGGGAGGGGAGGCAATGTGTGAGTCCTTTTGGAGCTGGGACTCAATCCACAACAGAGACAGCTCAAGCAGGGCCCTGCCAT
GGTCCACACTGAGGTTTCCTCTGCAGTGGTGCTGTCCACTGAGGGGTTATGGTGTGAGGGCCCCTGGGAGCCACGCCTTGGACTTCTGAG
TCTGCAGAGCACTCGGCTCCAGCCAGCTGGATGGCAGGTGGTCAGTGGAGCTGGTGACTGGTGGTTTCTGCAATGAGGTGTCAGATTAGC
CTAAGGGAAGCCTCTTCAGCAAGTATCATGCCTGGATCCCGGTCTTGGTTGTTTTATGAGAGGCCGATATGAATTGCCATTGCCTCCCAC
AAAGAAAAATGGACAAAATATGGGACCACATCTTTGAGATGAAATGTGCCCAAAATGAAAAGTAACTTGAGTATCCCAAGTTAAACTTAA
TCATTAGCTGCAAATGGACGATTTTCAAATTTCAAATAGTGATTTTTGAAGATTTGCCCAAACTAGAGTACTATCCCTCTTCACACTAAG
AGGCAGAAAGTGGTTTCACACACCCTTTTATTTAATCAGCTAAAGTGGGTGCGGTGACACACACCTGTAAACTCAACCACTAAGGAGACT
GAGGCGGGAGGATTACTTGAGCCCAGGAGTTCGAGATCAGCCTGAGCAACATAACAAGACCCTGTCTCAAATAATACTTAGCTATTACCC
ATATTGCTTTTAGCCTGCTGCCAGGAGGGGAGAAATGTTATTGTTTGAACAGATGTCAGATGTGAGTAATGCTCAGCTGTGTTCAATGTA

>66183_66183_5_PLEKHA5-LSM3_PLEKHA5_chr12_19475516_ENST00000424268_LSM3_chr3_14223081_ENST00000306024_length(amino acids)=604AA_BP=
MTSEEKKERPISMINEASNYNVTSDYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNAPVVRRGWLYKQDSTGMKLWKKRWFVLSDLC
LFYYRDEKEEGILGSILLPSFQIALLTSEDHINRKYAFKAAHPNMRTYYFCTDTGKEMELWMKAMLDAALVQTEPVKRVDKITSENAPTK
ETNNIPNHRVLIKPEIQNNQKNKEMSKIEEKKALEAEKYGFQKDGQDRPLTKINSVKLNSLPSEYESGSACPAQTVHYRPINLSSSENKI
VNVSLADLRGGNRPNTGPLYTEADRVIQRTNSMQQLEQWIKIQKGRGHEEETRGVISYQTLPRNMPSHRAQIMARYPEGYRTLPRNSKTR
PESICSVTPSTHDKTLGPGAEEKRRSMRDDTMWQLYEWQQRQFYNKQSTLPRHSTLSSPKTMVNISDQTMHSIPTSPSHGSIAAYQGYSP
QRTYRSEVSSPIQRGDVTIDRRHRAHHPKHVYVPDRRSVPAGLTLQSVSPQSLQGKTMKENEPIITMVHTMIENSALRPQLYQQFLRQKS

--------------------------------------------------------------
>66183_66183_6_PLEKHA5-LSM3_PLEKHA5_chr12_19475516_ENST00000429027_LSM3_chr3_14223081_ENST00000306024_length(transcript)=5684nt_BP=2415nt
GAGAAGGCGGCGGCGGCGGCTAGGGATCAGACATGGCGGCGGATCTGAACCTGGAGTGGATCTCCCTGCCCCGGTCCTGGACTTACGGGA
TCACCAGGGGCGGCCGAGTCTTCTTCATCAACGAGGAGGCCAAGAGCACCACCTGGCTGCACCCCGTCACCGGCGAGGCGGTGGTCACCG
GACACCGGCGGCAGAGCACAGATTTGCCTACTGGCTGGGAAGAAGCATATACTTTTGAAGGTGCAAGATACTATATAAACCATAATGAAA
GGAAAGTGACCTGCAAACATCCAGTCACAGGACAACCATCACAGGACAATTGTATTTTTGTAGTGAATGAACAGACTGTTGCAACCATGA
CATCTGAAGAAAAGAAGGAACGGCCAATAAGTATGATAAATGAAGCTTCTAACTATAACGTGACTTCAGATTATGCAGTGCATCCAATGA
GCCCTGTAGGCAGAACTTCACGAGCTTCAAAAAAAGTTCATAATTTTGGAAAGAGGTCAAATTCAATTAAAAGGAATCCTAATGCACCGG
TTGTCAGACGAGGTTGGCTTTATAAACAGGACAGTACTGGCATGAAATTGTGGAAGAAACGCTGGTTTGTGCTTTCTGACCTTTGCCTCT
TTTATTATAGAGATGAGAAAGAAGAGGGTATCCTGGGAAGCATACTGTTACCTAGTTTTCAGATAGCTTTGCTTACCTCTGAAGATCACA
TTAATCGCAAATATGCTTTTAAGGCAGCCCATCCAAACATGCGGACCTATTATTTCTGCACTGATACAGGAAAGGAAATGGAGTTGTGGA
TGAAAGCCATGTTAGATGCTGCCCTAGTACAGACAGAACCTGTGAAAAGAATTACCTTTAATTTCCGAGTGGACAAGATTACATCTGAAA
ATGCACCAACTAAAGAAACCAATAACATTCCCAACCATAGAGTGCTAATTAAACCAGAGATCCAAAACAATCAAAAAAACAAGGAAATGA
GCAAAATTGAAGAAAAAAAGGCATTAGAAGCTGAAAAATATGGATTTCAGAAGGATGGTCAAGATAGACCCTTAACAAAAATTAATAGTG
TAAAGCTGAATTCTCTGCCATCTGAATATGAGAGTGGGTCAGCATGCCCTGCTCAGACTGTGCACTACAGACCAATCAACTTGAGCAGTT
CAGAGAACAAAATAGTCAATGTTAGCCTGGCAGATCTTAGAGGTGGAAATCGCCCCAATACAGGGCCCTTATACACAGAGGCCGATCGAG
TCATACAGAGAACAAATTCAATGCAGCAGTTGGAACAGTGGATTAAAATCCAGAAGGGGAGGGGTCATGAAGAAGAAACCAGGGGAGTAA
TTTCTTACCAAACATTACCAAGAAATATGCCAAGTCACAGAGCCCAGATTATGGCCCGCTACCCTGAAGGTTATAGAACACTCCCAAGAA
ACAGCAAGACAAGGCCTGAAAGTATCTGCAGTGTAACCCCTTCCACTCATGACAAGACATTAGGACCCGGAGCGGAGGAGAAACGGAGGT
CCATGAGAGATGACACAATGTGGCAGCTCTACGAATGGCAGCAGCGTCAGTTTTATAACAAACAGAGCACCCTCCCTCGACACAGTACTT
TGAGTAGTCCCAAAACCATGGTAAATATTTCTGACCAGACAATGCACTCTATTCCCACATCACCTTCCCACGGGTCAATAGCTGCTTATC
AGGGATACTCCCCTCAACGAACTTACAGATCGGAAGTGTCTTCACCAATTCAGAGAGGAGATGTGACAATAGACCGCAGACACAGGGCCC
ATCACCCTAAGCATGTCTATGTGCCTGACAGAAGGTCAGTGCCAGCTGGCCTGACTTTACAGTCTGTTAGTCCCCAGAGCCTCCAAGGGA
AAACGCCAGAGGAGCTTACGCTGCTGCTAATAAAGCTGAGACGGCAGCAAGCCGAACTGAGTAGTATCCGGGAGCATACGTTAGCACAGC
TCATGCAGCTAAAGCTTGAGGCCCACAGCCCAAAGAATGAAATTCTTTCACATCATCTCCAAAGGAACACCATATATTTGGATCATCAGA
TGAAAGAAAATGAACCTATTATCACCATGGTTCACACAATGATTGAGAACTCGGCGCTAAGACCCCAACTGTACCAGCAATTCTTAAGAC
AGAAGAGCAAGATAAGTCTATATTGTCTGTCACAAGATGAAGGTAGAGGCACATTATACAAATACAGACCTGAAGAAGTAGATATTGATG
CCAAGTTAAGCCGATTATGTGAACAAGATAAAGTGGTGCATGCTCTGGAAGAGAAACTTCAGCAACTCCACAAGGAGAAAAGCCATTCAG
ACAGTGGTGTTACAAAGGGATGATTTACAAAATGGACTGCTTAGTACGTGTCGAGAACTTTCTCGAGCCACTGCCAGGAGCCCCTGGATC
TTATCAGGCTCAGCCTAGATGAGCGAATTTATGTGAAAATGAGAAATGACCGAGAGCTTCGAGGCAGATTACATGCTTATGATCAACATT
TAAATATGATCTTGGGAGATGTGGAAGAAACTGTGACTACTATAGAAATTGATGAAGAAACATATGAAGAGATATATAAATCAACGAAAC
GGAATATTCCAATGCTCTTTGTCCGGGGAGATGGCGTTGTCCTGGTTGCCCCTCCACTGAGAGTTGGCTGAAACAAAGAATTTGTCCTGT
ATGGAAAACGGGAGACTTTGTACAGTGGCCTCTCTAAAAGTACAAAACATTCATAAGAGAAACCTGCATACATTTTGATATTAAGAAATA
ATTCCGGGGATTCTTCCACTCCTGAAATGAGTTGATTTGCAGATAACTCACAACTTCTTAAGCTAAATGGTATTTTCATTTTTCTCAAGC
TCTCCAATAAATATGACCACCAAGATGCAGAACTCTTTCAGGACTTCTTTTGCTCCATTATTCTCACAGATACTTACTGATTTTTCTTTT
CTTTAAATTGGTGTTTCCTTGTAGATTTTTTTAAGTGCGGTCTTCTGTCTTGTGAATTATTTAAAGTAAGCATGTCTTACCTTCACTTAG
CACACATTTGCAGTGCACCTACTGTGTTTGAGGCACCAGGTTTGAGTGCTGGGAACCAGAGTTTTATCAAAATGCTTTCTGGGCCAGACA
TGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGATCACCTGAGGTCAGGCGTTTGAGACCAGCCTGGCCAACA
TGGTGAAACCCTTTCTCTACTGAAAATATAAAAATTAGCCAGGCGTGGTGGCGCATACTTGTAATCCCAGCTACTCAGGAGGCTGAGGCA
GTAGACGCTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCAAGATCACACCATTGCACTTCAACCTGGTCAACAGAGCGAGACTCCGTGT
CAAAAAAAAAAAAAAAAAAGTTTTCTGCCCTCAAGTCTTCTGGGGAGGCAGATGTTTAAACCAACAATTGCAGGCAGTAAGATTAGTGCT
GATAGAATCATGCACATGCAGGATGCCATAGGAGCATGGGGAAGAGCACCCAAATATGGGAGAAAGGGGCAGAGGGACATTGTAAACATC
AACCCTGCAGTAGAAGACAGAGCAAAGCATGATTTCTCTTTTCTCTGGCCTGATTTAATTCTAAGGTCAGACGTTCAGCTTGATCATAAC
CTGTTTATAATTATGACTCAGACCATTTTTCCACTCTTGGATCATTGGCCATTAATGATGAGGGGTCTCAAACAACATGTCTCAGTGACA
CAGTAAAGCAGAAATTGGCTGAAAGCAAAGCTGTTTTTATTTCTAGCTTCAGTCAGCACATAATGCTTAAAACCTAAAGAGGAAAGTAAA
AGCGTGTTACAATCTCTCAAACTTTATCAAGACAGGGCTTAGAACCTGACATCCTCCGCTATGGTCATTCCATTTTGAAATGTAGAAAAT
CCAACTTGTGGATGGTTTGTCTGTAAATGAGCTGAATGTGTGTGCGTGTTCATTATCAAGCACGATATGCTCACAAATGCACAGTACTTT
AAGCCTTGTGCAAGAAAGATGCTTTCAGTAAACATATTTAAAAGGTTTTATTTTCCTTACTAATGGTACATGCCCCTGCAAGTTCATGGA
GAAGAGAAAAACAAGTGTGGGTGAGCTGATGGAGGCTTCATCTTAGGTGAGGAGGCAGGAGAGACACCCTCCCTTCACTTGTGCCATCCC
CACGCTTTGTCCTTAAGCTGTAGTGGTCCCAGGAGATAACCTGTTTACAGCAGCCCATTCAGTATTGAAAAATGAACTCCCTCCTGCAGA
ATGTTAGAAGAAACAACCTCAAAGACCTCAGGCCGCCTGTGGTCATTAGTATGTGGCAGCAAGATTGAACCTGCCTGCCTCCTACCTGTG
TGAGCCTGTGGTGTGGGTGTGGTACCAAGGCCCTGGCTCTGGGCAGTCTGTTGGCTCCTGGTGTTCACTAAGGCGTGGGGTGACAGGCCA
TCTGGCCTCGCTCTGCCAGTCTGCAGTTCTCCCCAGCACTGCATTCATTTTTAGTGGTTTCTGATAGTCACACTGAATTCCTGGACACTT
TCTTCTCTTCATTCTTAGTTATCTTTCTCCTTTTTCTCCTGGAACTGATAGTTTACACTAAAACTTTTGGCTGTGAGGACTTGATTATAC
ACATTTCTAAAACCCATGAACCTTAATATCTGACACTGTTACTCTCATATGCACACACAACTAAAACATACCAACCTACTTCATTTCCTA
GCTGCTAAGATACAAGGGGAGGGACAATAAAAGGTTAACTGCAGAATAGCCACCTATGTGTCAGGAAATGGAGGGAGGGGAGGCAATGTG
TGAGTCCTTTTGGAGCTGGGACTCAATCCACAACAGAGACAGCTCAAGCAGGGCCCTGCCATGGTCCACACTGAGGTTTCCTCTGCAGTG
GTGCTGTCCACTGAGGGGTTATGGTGTGAGGGCCCCTGGGAGCCACGCCTTGGACTTCTGAGTCTGCAGAGCACTCGGCTCCAGCCAGCT
GGATGGCAGGTGGTCAGTGGAGCTGGTGACTGGTGGTTTCTGCAATGAGGTGTCAGATTAGCCTAAGGGAAGCCTCTTCAGCAAGTATCA
TGCCTGGATCCCGGTCTTGGTTGTTTTATGAGAGGCCGATATGAATTGCCATTGCCTCCCACAAAGAAAAATGGACAAAATATGGGACCA
CATCTTTGAGATGAAATGTGCCCAAAATGAAAAGTAACTTGAGTATCCCAAGTTAAACTTAATCATTAGCTGCAAATGGACGATTTTCAA
ATTTCAAATAGTGATTTTTGAAGATTTGCCCAAACTAGAGTACTATCCCTCTTCACACTAAGAGGCAGAAAGTGGTTTCACACACCCTTT
TATTTAATCAGCTAAAGTGGGTGCGGTGACACACACCTGTAAACTCAACCACTAAGGAGACTGAGGCGGGAGGATTACTTGAGCCCAGGA
GTTCGAGATCAGCCTGAGCAACATAACAAGACCCTGTCTCAAATAATACTTAGCTATTACCCATATTGCTTTTAGCCTGCTGCCAGGAGG
GGAGAAATGTTATTGTTTGAACAGATGTCAGATGTGAGTAATGCTCAGCTGTGTTCAATGTAGAAAATTAATAAAAGTTCCAGGAGTCAT

>66183_66183_6_PLEKHA5-LSM3_PLEKHA5_chr12_19475516_ENST00000429027_LSM3_chr3_14223081_ENST00000306024_length(amino acids)=776AA_BP=
MAADLNLEWISLPRSWTYGITRGGRVFFINEEAKSTTWLHPVTGEAVVTGHRRQSTDLPTGWEEAYTFEGARYYINHNERKVTCKHPVTG
QPSQDNCIFVVNEQTVATMTSEEKKERPISMINEASNYNVTSDYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNAPVVRRGWLYKQD
STGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSEDHINRKYAFKAAHPNMRTYYFCTDTGKEMELWMKAMLDAALVQ
TEPVKRITFNFRVDKITSENAPTKETNNIPNHRVLIKPEIQNNQKNKEMSKIEEKKALEAEKYGFQKDGQDRPLTKINSVKLNSLPSEYE
SGSACPAQTVHYRPINLSSSENKIVNVSLADLRGGNRPNTGPLYTEADRVIQRTNSMQQLEQWIKIQKGRGHEEETRGVISYQTLPRNMP
SHRAQIMARYPEGYRTLPRNSKTRPESICSVTPSTHDKTLGPGAEEKRRSMRDDTMWQLYEWQQRQFYNKQSTLPRHSTLSSPKTMVNIS
DQTMHSIPTSPSHGSIAAYQGYSPQRTYRSEVSSPIQRGDVTIDRRHRAHHPKHVYVPDRRSVPAGLTLQSVSPQSLQGKTPEELTLLLI
KLRRQQAELSSIREHTLAQLMQLKLEAHSPKNEILSHHLQRNTIYLDHQMKENEPIITMVHTMIENSALRPQLYQQFLRQKSKISLYCLS

--------------------------------------------------------------
>66183_66183_7_PLEKHA5-LSM3_PLEKHA5_chr12_19475516_ENST00000538714_LSM3_chr3_14223081_ENST00000306024_length(transcript)=5521nt_BP=2252nt
AGACATGGCGGCGGATCTGAACCTGGAGTGGATCTCCCTGCCCCGGTCCTGGACTTACGGGATCACCAGGGGCGGCCGAGTCTTCTTCAT
CAACGAGGAGGCCAAGAGCACCACCTGGCTGCACCCCGTCACCGGCGAGGCGGTGGTCACCGGACACCGGCGGCAGAGCACAGATTTGCC
TACTGGCTGGGAAGAAGCATATACTTTTGAAGGTGCAAGATACTATATAAACCATAATGAAAGGAAAGTGACCTGCAAACATCCAGTCAC
AGGACAACCATCACAGGACAATTGTATTTTTGTAGTGAATGAACAGACTGTTGCAACCATGACATCTGAAGAAAAGAAGGAACGGCCAAT
AAGTATGATAAATGAAGCTTCTAACTATAACGTGACTTCAGATTATGCAGTGCATCCAATGAGCCCTGTAGGCAGAACTTCACGAGCTTC
AAAAAAAGTTCATAATTTTGGAAAGAGGTCAAATTCAATTAAAAGGAATCCTAATGCACCGGTTGTCAGACGAGGTTGGCTTTATAAACA
GGACAGTACTGGCATGAAATTGTGGAAGAAACGCTGGTTTGTGCTTTCTGACCTTTGCCTCTTTTATTATAGAGATGAGAAAGAAGAGGG
TATCCTGGGAAGCATACTGTTACCTAGTTTTCAGATAGCTTTGCTTACCTCTGAAGATCACATTAATCGCAAATATGCTTTTAAGGCAGC
CCATCCAAACATGCGGACCTATTATTTCTGCACTGATACAGGAAAGGAAATGGAGTTGTGGATGAAAGCCATGTTAGATGCTGCCCTAGT
ACAGACAGAACCTGTGAAAAGAGTGGACAAGATTACATCTGAAAATGCACCAACTAAAGAAACCAATAACATTCCCAACCATAGAGTGCT
AATTAAACCAGAGATCCAAAACAATCAAAAAAACAAGGAAATGAGCAAAATTGAAGAAAAAAAGGCATTAGAAGCTGAAAAATATGGATT
TCAGAAGGATGGTCAAGATAGACCCTTAACAAAAATTAATAGTGTAAAGCTGAATTCTCTGCCATCTGAATATGAGAGTGGGTCAGCATG
CCCTGCTCAGACTGTGCACTACAGACCAATCAACTTGAGCAGTTCAGAGAACAAAATAGTCAATGTTAGCCTGGCAGATCTTAGAGGTGG
AAATCGCCCCAATACAGGGCCCTTATACACAGAGGCCGATCGAGTCATACAGAGAACAAATTCAATGCAGCAGTTGGAACAGTGGATTAA
AATCCAGAAGGGGAGGGGTCATGAAGAAGAAACCAGGGGAGTAATTTCTTACCAAACATTACCAAGAAATATGCCAAGTCACAGAGCCCA
GATTATGGCCCGCTACCCTGAAGGTTATAGAACACTCCCAAGAAACAGCAAGACAAGGCCTGAAAGTATCTGCAGTGTAACCCCTTCCAC
TCATGACAAGACATTAGGACCCGGAGCGGAGGAGAAACGGAGGTCCATGAGAGATGACACAATGTGGCAGCTCTACGAATGGCAGCAGCG
TCAGTTTTATAACAAACAGAGCACCCTCCCTCGACACAGTACTTTGAGTAGTCCCAAAACCATGGTAAATATTTCTGACCAGACAATGCA
CTCTATTCCCACATCACCTTCCCACGGGTCAATAGCTGCTTATCAGGGATACTCCCCTCAACGAACTTACAGATCGGAAGTGTCTTCACC
AATTCAGAGAGGAGATGTGACAATAGACCGCAGACACAGGGCCCATCACCCTAAGCATGTCTATGTGCCTGACAGAAGGTCAGTGCCAGC
TGGCCTGACTTTACAGTCTGTTAGTCCCCAGAGCCTCCAAGGGAAAACGCCAGAGGAGCTTACGCTGCTGCTAATAAAGCTGAGACGGCA
GCAAGCCGAACTGAGTAGTATCCGGGAGCATACGTTAGCACAGCTCATGCAGCTAAAGCTTGAGGCCCACAGCCCAAAGAATGAAATTCT
TTCACATCATCTCCAAAGGAACACCATATATTTGGATCATCAGCTGTCACAAGATGAAGGTAGAGGCACATTATACAAATACAGACCTGA
AGAAGTAGATATTGATGCCAAGTTAAGCCGATTATGTGAACAAGATAAAGTGGTGCATGCTCTGGAAGAGAAACTTCAGCAACTCCACAA
GGAGAAAAGCCATTCAGACAGTGGTGTTACAAAGGGATGATTTACAAAATGGACTGCTTAGTACGTGTCGAGAACTTTCTCGAGCCACTG
CCAGGAGCCCCTGGATCTTATCAGGCTCAGCCTAGATGAGCGAATTTATGTGAAAATGAGAAATGACCGAGAGCTTCGAGGCAGATTACA
TGCTTATGATCAACATTTAAATATGATCTTGGGAGATGTGGAAGAAACTGTGACTACTATAGAAATTGATGAAGAAACATATGAAGAGAT
ATATAAATCAACGAAACGGAATATTCCAATGCTCTTTGTCCGGGGAGATGGCGTTGTCCTGGTTGCCCCTCCACTGAGAGTTGGCTGAAA
CAAAGAATTTGTCCTGTATGGAAAACGGGAGACTTTGTACAGTGGCCTCTCTAAAAGTACAAAACATTCATAAGAGAAACCTGCATACAT
TTTGATATTAAGAAATAATTCCGGGGATTCTTCCACTCCTGAAATGAGTTGATTTGCAGATAACTCACAACTTCTTAAGCTAAATGGTAT
TTTCATTTTTCTCAAGCTCTCCAATAAATATGACCACCAAGATGCAGAACTCTTTCAGGACTTCTTTTGCTCCATTATTCTCACAGATAC
TTACTGATTTTTCTTTTCTTTAAATTGGTGTTTCCTTGTAGATTTTTTTAAGTGCGGTCTTCTGTCTTGTGAATTATTTAAAGTAAGCAT
GTCTTACCTTCACTTAGCACACATTTGCAGTGCACCTACTGTGTTTGAGGCACCAGGTTTGAGTGCTGGGAACCAGAGTTTTATCAAAAT
GCTTTCTGGGCCAGACATGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGATCACCTGAGGTCAGGCGTTTGA
GACCAGCCTGGCCAACATGGTGAAACCCTTTCTCTACTGAAAATATAAAAATTAGCCAGGCGTGGTGGCGCATACTTGTAATCCCAGCTA
CTCAGGAGGCTGAGGCAGTAGACGCTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCAAGATCACACCATTGCACTTCAACCTGGTCAAC
AGAGCGAGACTCCGTGTCAAAAAAAAAAAAAAAAAAGTTTTCTGCCCTCAAGTCTTCTGGGGAGGCAGATGTTTAAACCAACAATTGCAG
GCAGTAAGATTAGTGCTGATAGAATCATGCACATGCAGGATGCCATAGGAGCATGGGGAAGAGCACCCAAATATGGGAGAAAGGGGCAGA
GGGACATTGTAAACATCAACCCTGCAGTAGAAGACAGAGCAAAGCATGATTTCTCTTTTCTCTGGCCTGATTTAATTCTAAGGTCAGACG
TTCAGCTTGATCATAACCTGTTTATAATTATGACTCAGACCATTTTTCCACTCTTGGATCATTGGCCATTAATGATGAGGGGTCTCAAAC
AACATGTCTCAGTGACACAGTAAAGCAGAAATTGGCTGAAAGCAAAGCTGTTTTTATTTCTAGCTTCAGTCAGCACATAATGCTTAAAAC
CTAAAGAGGAAAGTAAAAGCGTGTTACAATCTCTCAAACTTTATCAAGACAGGGCTTAGAACCTGACATCCTCCGCTATGGTCATTCCAT
TTTGAAATGTAGAAAATCCAACTTGTGGATGGTTTGTCTGTAAATGAGCTGAATGTGTGTGCGTGTTCATTATCAAGCACGATATGCTCA
CAAATGCACAGTACTTTAAGCCTTGTGCAAGAAAGATGCTTTCAGTAAACATATTTAAAAGGTTTTATTTTCCTTACTAATGGTACATGC
CCCTGCAAGTTCATGGAGAAGAGAAAAACAAGTGTGGGTGAGCTGATGGAGGCTTCATCTTAGGTGAGGAGGCAGGAGAGACACCCTCCC
TTCACTTGTGCCATCCCCACGCTTTGTCCTTAAGCTGTAGTGGTCCCAGGAGATAACCTGTTTACAGCAGCCCATTCAGTATTGAAAAAT
GAACTCCCTCCTGCAGAATGTTAGAAGAAACAACCTCAAAGACCTCAGGCCGCCTGTGGTCATTAGTATGTGGCAGCAAGATTGAACCTG
CCTGCCTCCTACCTGTGTGAGCCTGTGGTGTGGGTGTGGTACCAAGGCCCTGGCTCTGGGCAGTCTGTTGGCTCCTGGTGTTCACTAAGG
CGTGGGGTGACAGGCCATCTGGCCTCGCTCTGCCAGTCTGCAGTTCTCCCCAGCACTGCATTCATTTTTAGTGGTTTCTGATAGTCACAC
TGAATTCCTGGACACTTTCTTCTCTTCATTCTTAGTTATCTTTCTCCTTTTTCTCCTGGAACTGATAGTTTACACTAAAACTTTTGGCTG
TGAGGACTTGATTATACACATTTCTAAAACCCATGAACCTTAATATCTGACACTGTTACTCTCATATGCACACACAACTAAAACATACCA
ACCTACTTCATTTCCTAGCTGCTAAGATACAAGGGGAGGGACAATAAAAGGTTAACTGCAGAATAGCCACCTATGTGTCAGGAAATGGAG
GGAGGGGAGGCAATGTGTGAGTCCTTTTGGAGCTGGGACTCAATCCACAACAGAGACAGCTCAAGCAGGGCCCTGCCATGGTCCACACTG
AGGTTTCCTCTGCAGTGGTGCTGTCCACTGAGGGGTTATGGTGTGAGGGCCCCTGGGAGCCACGCCTTGGACTTCTGAGTCTGCAGAGCA
CTCGGCTCCAGCCAGCTGGATGGCAGGTGGTCAGTGGAGCTGGTGACTGGTGGTTTCTGCAATGAGGTGTCAGATTAGCCTAAGGGAAGC
CTCTTCAGCAAGTATCATGCCTGGATCCCGGTCTTGGTTGTTTTATGAGAGGCCGATATGAATTGCCATTGCCTCCCACAAAGAAAAATG
GACAAAATATGGGACCACATCTTTGAGATGAAATGTGCCCAAAATGAAAAGTAACTTGAGTATCCCAAGTTAAACTTAATCATTAGCTGC
AAATGGACGATTTTCAAATTTCAAATAGTGATTTTTGAAGATTTGCCCAAACTAGAGTACTATCCCTCTTCACACTAAGAGGCAGAAAGT
GGTTTCACACACCCTTTTATTTAATCAGCTAAAGTGGGTGCGGTGACACACACCTGTAAACTCAACCACTAAGGAGACTGAGGCGGGAGG
ATTACTTGAGCCCAGGAGTTCGAGATCAGCCTGAGCAACATAACAAGACCCTGTCTCAAATAATACTTAGCTATTACCCATATTGCTTTT
AGCCTGCTGCCAGGAGGGGAGAAATGTTATTGTTTGAACAGATGTCAGATGTGAGTAATGCTCAGCTGTGTTCAATGTAGAAAATTAATA

>66183_66183_7_PLEKHA5-LSM3_PLEKHA5_chr12_19475516_ENST00000538714_LSM3_chr3_14223081_ENST00000306024_length(amino acids)=731AA_BP=
MAADLNLEWISLPRSWTYGITRGGRVFFINEEAKSTTWLHPVTGEAVVTGHRRQSTDLPTGWEEAYTFEGARYYINHNERKVTCKHPVTG
QPSQDNCIFVVNEQTVATMTSEEKKERPISMINEASNYNVTSDYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNAPVVRRGWLYKQD
STGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSEDHINRKYAFKAAHPNMRTYYFCTDTGKEMELWMKAMLDAALVQ
TEPVKRVDKITSENAPTKETNNIPNHRVLIKPEIQNNQKNKEMSKIEEKKALEAEKYGFQKDGQDRPLTKINSVKLNSLPSEYESGSACP
AQTVHYRPINLSSSENKIVNVSLADLRGGNRPNTGPLYTEADRVIQRTNSMQQLEQWIKIQKGRGHEEETRGVISYQTLPRNMPSHRAQI
MARYPEGYRTLPRNSKTRPESICSVTPSTHDKTLGPGAEEKRRSMRDDTMWQLYEWQQRQFYNKQSTLPRHSTLSSPKTMVNISDQTMHS
IPTSPSHGSIAAYQGYSPQRTYRSEVSSPIQRGDVTIDRRHRAHHPKHVYVPDRRSVPAGLTLQSVSPQSLQGKTPEELTLLLIKLRRQQ
AELSSIREHTLAQLMQLKLEAHSPKNEILSHHLQRNTIYLDHQLSQDEGRGTLYKYRPEEVDIDAKLSRLCEQDKVVHALEEKLQQLHKE

--------------------------------------------------------------
>66183_66183_8_PLEKHA5-LSM3_PLEKHA5_chr12_19475516_ENST00000539256_LSM3_chr3_14223081_ENST00000306024_length(transcript)=5276nt_BP=2007nt
TCAGACATGGCGGCGGATCTGAACCTGGAGTGGATCTCCCTGCCCCGGTCCTGGACTTACGGGATCACCAGGGGCGGCCGAGTCTTCTTC
ATCAACGAGGAGGCCAAGAGCACCACCTGGCTGCACCCCGTCACCGGCGAGGCGGTGGTCACCGGACACCGGCGGCAGAGCACAGATTTG
CCTACTGGCTGGGAAGAAGCATATACTTTTGAAGGTGCAAGATACTATATAAACCATAATGAAAGGAAAGTGACCTGCAAACATCCAGTC
ACAGGACAACCATCACAGGACAATTGTATTTTTGTAGTGAATGAACAGACTGTTGCAACCATGACATCTGAAGAAAAGAAGGAACGGCCA
ATAAGTATGATAAATGAAGCTTCTAACTATAACGTGACTTCAGATTATGCAGTGCATCCAATGAGCCCTGTAGGCAGAACTTCACGAGCT
TCAAAAAAAGTTCATAATTTTGGAAAGAGGTCAAATTCAATTAAAAGGAATCCTAATGCACCGGTTGTCAGACGAGGTTGGCTTTATAAA
CAGATGAGAAAGAAGAGGGTATCCTGGGAAGCATACTGTTACCTAGTTTTCAGATAGCTTTGCTTACCTCTGAAGATCACATTAATCGCA
AATATGCTTTTAAGGCAGCCCATCCAAACATGCGGACCTATTATTTCTGCACTGATACAGGAAAGGAAATGGAGTTGTGGATGAAAGCCA
TGTTAGATGCTGCCCTAGTACAGACAGAACCTGTGAAAAGAGTGGACAAGATTACATCTGAAAATGCACCAACTAAAGAAACCAATAACA
TTCCCAACCATAGAGTGCTAATTAAACCAGAGATCCAAAACAATCAAAAAAACAAGGAAATGAGCAAAATTGAAGAAAAAAAGGCATTAG
AAGCTGAAAAATATGGATTTCAGAAGGATGGTCAAGATAGACCCTTAACAAAAATTAATAGTGTAAAGCTGAATTCTCTGCCATCTGAAT
ATGAGAGTGGGTCAGCATGCCCTGCTCAGACTGTGCACTACAGACCAATCAACTTGAGCAGTTCAGAGAACAAAATAGTCAATGTTAGCC
TGGCAGATCTTAGAGGTGGAAATCGCCCCAATACAGGGCCCTTATACACAGAGGCCGATCGAGTCATACAGAGAACAAATTCAATGCAGC
AGTTGGAACAGTGGATTAAAATCCAGAAGGGGAGGGGTCATGAAGAAGAAACCAGGGGAGTAATTTCTTACCAAACATTACCAAGAAATA
TGCCAAGTCACAGAGCCCAGATTATGGCCCGCTACCCTGAAGGTTATAGAACACTCCCAAGAAACAGCAAGACAAGGCCTGAAAGTATCT
GCAGTGTAACCCCTTCCACTCATGACAAGACATTAGGACCCGGAGCGGAGGAGAAACGGAGGTCCATGAGAGATGACACAATGTGGCAGC
TCTACGAATGGCAGCAGCGTCAGTTTTATAACAAACAGAGCACCCTCCCTCGACACAGTACTTTGAGTAGTCCCAAAACCATGGTAAATA
TTTCTGACCAGACAATGCACTCTATTCCCACATCACCTTCCCACGGGTCAATAGCTGCTTATCAGGGATACTCCCCTCAACGAACTTACA
GATCGGAAGTGTCTTCACCAATTCAGAGAGGAGATGTGACAATAGACCGCAGACACAGGGCCCATCACCCTAAGCATGTCTATGTGCCTG
ACAGAAGGTCAGTGCCAGCTGGCCTGACTTTACAGTCTGTTAGTCCCCAGAGCCTCCAAGGGAAAACGCTGTCACAAGATGAAGGTAGAG
GCACATTATACAAATACAGACCTGAAGAAGTAGATATTGATGCCAAGTTAAGCCGATTATGTGAACAAGATAAAGTGGTGCATGCTCTGG
AAGAGAAACTTCAGCAACTCCACAAGGAGAAAAGCCATTCAGACAGTGGTGTTACAAAGGGATGATTTACAAAATGGACTGCTTAGTACG
TGTCGAGAACTTTCTCGAGCCACTGCCAGGAGCCCCTGGATCTTATCAGGCTCAGCCTAGATGAGCGAATTTATGTGAAAATGAGAAATG
ACCGAGAGCTTCGAGGCAGATTACATGCTTATGATCAACATTTAAATATGATCTTGGGAGATGTGGAAGAAACTGTGACTACTATAGAAA
TTGATGAAGAAACATATGAAGAGATATATAAATCAACGAAACGGAATATTCCAATGCTCTTTGTCCGGGGAGATGGCGTTGTCCTGGTTG
CCCCTCCACTGAGAGTTGGCTGAAACAAAGAATTTGTCCTGTATGGAAAACGGGAGACTTTGTACAGTGGCCTCTCTAAAAGTACAAAAC
ATTCATAAGAGAAACCTGCATACATTTTGATATTAAGAAATAATTCCGGGGATTCTTCCACTCCTGAAATGAGTTGATTTGCAGATAACT
CACAACTTCTTAAGCTAAATGGTATTTTCATTTTTCTCAAGCTCTCCAATAAATATGACCACCAAGATGCAGAACTCTTTCAGGACTTCT
TTTGCTCCATTATTCTCACAGATACTTACTGATTTTTCTTTTCTTTAAATTGGTGTTTCCTTGTAGATTTTTTTAAGTGCGGTCTTCTGT
CTTGTGAATTATTTAAAGTAAGCATGTCTTACCTTCACTTAGCACACATTTGCAGTGCACCTACTGTGTTTGAGGCACCAGGTTTGAGTG
CTGGGAACCAGAGTTTTATCAAAATGCTTTCTGGGCCAGACATGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGT
GGATCACCTGAGGTCAGGCGTTTGAGACCAGCCTGGCCAACATGGTGAAACCCTTTCTCTACTGAAAATATAAAAATTAGCCAGGCGTGG
TGGCGCATACTTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGTAGACGCTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCAAGATCAC
ACCATTGCACTTCAACCTGGTCAACAGAGCGAGACTCCGTGTCAAAAAAAAAAAAAAAAAAGTTTTCTGCCCTCAAGTCTTCTGGGGAGG
CAGATGTTTAAACCAACAATTGCAGGCAGTAAGATTAGTGCTGATAGAATCATGCACATGCAGGATGCCATAGGAGCATGGGGAAGAGCA
CCCAAATATGGGAGAAAGGGGCAGAGGGACATTGTAAACATCAACCCTGCAGTAGAAGACAGAGCAAAGCATGATTTCTCTTTTCTCTGG
CCTGATTTAATTCTAAGGTCAGACGTTCAGCTTGATCATAACCTGTTTATAATTATGACTCAGACCATTTTTCCACTCTTGGATCATTGG
CCATTAATGATGAGGGGTCTCAAACAACATGTCTCAGTGACACAGTAAAGCAGAAATTGGCTGAAAGCAAAGCTGTTTTTATTTCTAGCT
TCAGTCAGCACATAATGCTTAAAACCTAAAGAGGAAAGTAAAAGCGTGTTACAATCTCTCAAACTTTATCAAGACAGGGCTTAGAACCTG
ACATCCTCCGCTATGGTCATTCCATTTTGAAATGTAGAAAATCCAACTTGTGGATGGTTTGTCTGTAAATGAGCTGAATGTGTGTGCGTG
TTCATTATCAAGCACGATATGCTCACAAATGCACAGTACTTTAAGCCTTGTGCAAGAAAGATGCTTTCAGTAAACATATTTAAAAGGTTT
TATTTTCCTTACTAATGGTACATGCCCCTGCAAGTTCATGGAGAAGAGAAAAACAAGTGTGGGTGAGCTGATGGAGGCTTCATCTTAGGT
GAGGAGGCAGGAGAGACACCCTCCCTTCACTTGTGCCATCCCCACGCTTTGTCCTTAAGCTGTAGTGGTCCCAGGAGATAACCTGTTTAC
AGCAGCCCATTCAGTATTGAAAAATGAACTCCCTCCTGCAGAATGTTAGAAGAAACAACCTCAAAGACCTCAGGCCGCCTGTGGTCATTA
GTATGTGGCAGCAAGATTGAACCTGCCTGCCTCCTACCTGTGTGAGCCTGTGGTGTGGGTGTGGTACCAAGGCCCTGGCTCTGGGCAGTC
TGTTGGCTCCTGGTGTTCACTAAGGCGTGGGGTGACAGGCCATCTGGCCTCGCTCTGCCAGTCTGCAGTTCTCCCCAGCACTGCATTCAT
TTTTAGTGGTTTCTGATAGTCACACTGAATTCCTGGACACTTTCTTCTCTTCATTCTTAGTTATCTTTCTCCTTTTTCTCCTGGAACTGA
TAGTTTACACTAAAACTTTTGGCTGTGAGGACTTGATTATACACATTTCTAAAACCCATGAACCTTAATATCTGACACTGTTACTCTCAT
ATGCACACACAACTAAAACATACCAACCTACTTCATTTCCTAGCTGCTAAGATACAAGGGGAGGGACAATAAAAGGTTAACTGCAGAATA
GCCACCTATGTGTCAGGAAATGGAGGGAGGGGAGGCAATGTGTGAGTCCTTTTGGAGCTGGGACTCAATCCACAACAGAGACAGCTCAAG
CAGGGCCCTGCCATGGTCCACACTGAGGTTTCCTCTGCAGTGGTGCTGTCCACTGAGGGGTTATGGTGTGAGGGCCCCTGGGAGCCACGC
CTTGGACTTCTGAGTCTGCAGAGCACTCGGCTCCAGCCAGCTGGATGGCAGGTGGTCAGTGGAGCTGGTGACTGGTGGTTTCTGCAATGA
GGTGTCAGATTAGCCTAAGGGAAGCCTCTTCAGCAAGTATCATGCCTGGATCCCGGTCTTGGTTGTTTTATGAGAGGCCGATATGAATTG
CCATTGCCTCCCACAAAGAAAAATGGACAAAATATGGGACCACATCTTTGAGATGAAATGTGCCCAAAATGAAAAGTAACTTGAGTATCC
CAAGTTAAACTTAATCATTAGCTGCAAATGGACGATTTTCAAATTTCAAATAGTGATTTTTGAAGATTTGCCCAAACTAGAGTACTATCC
CTCTTCACACTAAGAGGCAGAAAGTGGTTTCACACACCCTTTTATTTAATCAGCTAAAGTGGGTGCGGTGACACACACCTGTAAACTCAA
CCACTAAGGAGACTGAGGCGGGAGGATTACTTGAGCCCAGGAGTTCGAGATCAGCCTGAGCAACATAACAAGACCCTGTCTCAAATAATA
CTTAGCTATTACCCATATTGCTTTTAGCCTGCTGCCAGGAGGGGAGAAATGTTATTGTTTGAACAGATGTCAGATGTGAGTAATGCTCAG

>66183_66183_8_PLEKHA5-LSM3_PLEKHA5_chr12_19475516_ENST00000539256_LSM3_chr3_14223081_ENST00000306024_length(amino acids)=463AA_BP=
MGSILLPSFQIALLTSEDHINRKYAFKAAHPNMRTYYFCTDTGKEMELWMKAMLDAALVQTEPVKRVDKITSENAPTKETNNIPNHRVLI
KPEIQNNQKNKEMSKIEEKKALEAEKYGFQKDGQDRPLTKINSVKLNSLPSEYESGSACPAQTVHYRPINLSSSENKIVNVSLADLRGGN
RPNTGPLYTEADRVIQRTNSMQQLEQWIKIQKGRGHEEETRGVISYQTLPRNMPSHRAQIMARYPEGYRTLPRNSKTRPESICSVTPSTH
DKTLGPGAEEKRRSMRDDTMWQLYEWQQRQFYNKQSTLPRHSTLSSPKTMVNISDQTMHSIPTSPSHGSIAAYQGYSPQRTYRSEVSSPI
QRGDVTIDRRHRAHHPKHVYVPDRRSVPAGLTLQSVSPQSLQGKTLSQDEGRGTLYKYRPEEVDIDAKLSRLCEQDKVVHALEEKLQQLH

--------------------------------------------------------------
>66183_66183_9_PLEKHA5-LSM3_PLEKHA5_chr12_19475516_ENST00000543806_LSM3_chr3_14223081_ENST00000306024_length(transcript)=5316nt_BP=2047nt
AAAAGAGATCACGGTGTGCCCCTTTGTCATCGTTCTGTCAGGAAGCATGTAATTTGTCTTTAGAAACCAGAAGCCTGAGACAAAGAAAAG
AACACAGATTTTTAGCAAAAGGCTATTTGCCATAATGAAAGGAAAGTGACCTGCAAACATCCAGTCACAGGACAACCATCACAGGACAAT
TGTATTTTTGTAGTGAATGAACAGACTGTTGCAACCATGACATCTGAAGAAAAGAAGGAACGGCCAATAAGTATGATAAATGAAGCTTCT
AACTATAACGTGACTTCAGATTATGCAGTGCATCCAATGAGCCCTGTAGGCAGAACTTCACGAGCTTCAAAAAAAGTTCATAATTTTGGA
AAGAGGTCAAATTCAATTAAAAGGAATCCTAATGCACCGGTTGTCAGACGAGGTTGGCTTTATAAACAGGACAGTACTGGCATGAAATTG
TGGAAGAAACGCTGGTTTGTGCTTTCTGACCTTTGCCTCTTTTATTATAGAGATGAGAAAGAAGAGGGTATCCTGGGAAGCATACTGTTA
CCTAGTTTTCAGATAGCTTTGCTTACCTCTGAAGATCACATTAATCGCAAATATGCTTTTAAGGCAGCCCATCCAAACATGCGGACCTAT
TATTTCTGCACTGATACAGGAAAGGAAATGGAGTTGTGGATGAAAGCCATGTTAGATGCTGCCCTAGTACAGACAGAACCTGTGAAAAGA
GTGGACAAGATTACATCTGAAAATGCACCAACTAAAGAAACCAATAACATTCCCAACCATAGAGTGCTAATTAAACCAGAGATCCAAAAC
AATCAAAAAAACAAGGAAATGAGCAAAATTGAAGAAAAAAAGGCATTAGAAGCTGAAAAATATGGATTTCAGAAGGATGGTCAAGATAGA
CCCTTAACAAAAATTAATAGTGTAAAGCTGAATTCTCTGCCATCTGAATATGAGAGTGGGTCAGCATGCCCTGCTCAGACTGTGCACTAC
AGACCAATCAACTTGAGCAGTTCAGAGAACAAAATAGTCAATGTTAGCCTGGCAGATCTTAGAGGTGGAAATCGCCCCAATACAGGGCCC
TTATACACAGAGGCCGATCGAGTCATACAGAGAACAAATTCAATGCAGCAGTTGGAACAGTGGATTAAAATCCAGAAGGGGAGGGGTCAT
GAAGAAGAAACCAGGGGAGTAATTTCTTACCAAACATTACCAAGAAATATGCCAAGTCACAGAGCCCAGATTATGGCCCGCTACCCTGAA
GGTTATAGAACACTCCCAAGAAACAGCAAGACAAGGCCTGAAAGTATCTGCAGTGTAACCCCTTCCACTCATGACAAGACATTAGGACCC
GGAGCGGAGGAGAAACGGAGGTCCATGAGAGATGACACAATGTGGCAGCTCTACGAATGGCAGCAGCGTCAGTTTTATAACAAACAGAGC
ACCCTCCCTCGACACAGTACTTTGAGTAGTCCCAAAACCATGGTAAATATTTCTGACCAGACAATGCACTCTATTCCCACATCACCTTCC
CACGGGTCAATAGCTGCTTATCAGGGATACTCCCCTCAACGAACTTACAGATCGGAAGTGTCTTCACCAATTCAGAGAGGAGATGTGACA
ATAGACCGCAGACACAGGGCCCATCACCCTAAGCATGTCTATGTGCCTGACAGAAGGTCAGTGCCAGCTGGCCTGACTTTACAGTCTGTT
AGTCCCCAGAGCCTCCAAGGGAAAACGATGAAAGAAAATGAACCTATTATCACCATGGTTCACACAATGATTGAGAACTCGGCGCTAAGA
CCCCAACTGTACCAGCAACTGTCACAAGATGAAGGTAGAGGCACATTATACAAATACAGACCTGAAGAAGTAGATATTGATGCCAAGTTA
AGCCGATTATGTGAACAAGATAAAGTGGTGCATGCTCTGGAAGAGAAACTTCAGCAACTCCACAAGGAGAAAAGCCATTCAGACAGTGGT
GTTACAAAGGGATGATTTACAAAATGGACTGCTTAGTACGTGTCGAGAACTTTCTCGAGCCACTGCCAGGAGCCCCTGGATCTTATCAGG
CTCAGCCTAGATGAGCGAATTTATGTGAAAATGAGAAATGACCGAGAGCTTCGAGGCAGATTACATGCTTATGATCAACATTTAAATATG
ATCTTGGGAGATGTGGAAGAAACTGTGACTACTATAGAAATTGATGAAGAAACATATGAAGAGATATATAAATCAACGAAACGGAATATT
CCAATGCTCTTTGTCCGGGGAGATGGCGTTGTCCTGGTTGCCCCTCCACTGAGAGTTGGCTGAAACAAAGAATTTGTCCTGTATGGAAAA
CGGGAGACTTTGTACAGTGGCCTCTCTAAAAGTACAAAACATTCATAAGAGAAACCTGCATACATTTTGATATTAAGAAATAATTCCGGG
GATTCTTCCACTCCTGAAATGAGTTGATTTGCAGATAACTCACAACTTCTTAAGCTAAATGGTATTTTCATTTTTCTCAAGCTCTCCAAT
AAATATGACCACCAAGATGCAGAACTCTTTCAGGACTTCTTTTGCTCCATTATTCTCACAGATACTTACTGATTTTTCTTTTCTTTAAAT
TGGTGTTTCCTTGTAGATTTTTTTAAGTGCGGTCTTCTGTCTTGTGAATTATTTAAAGTAAGCATGTCTTACCTTCACTTAGCACACATT
TGCAGTGCACCTACTGTGTTTGAGGCACCAGGTTTGAGTGCTGGGAACCAGAGTTTTATCAAAATGCTTTCTGGGCCAGACATGGTGGCT
CATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGATCACCTGAGGTCAGGCGTTTGAGACCAGCCTGGCCAACATGGTGAAA
CCCTTTCTCTACTGAAAATATAAAAATTAGCCAGGCGTGGTGGCGCATACTTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGTAGACGC
TTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCAAGATCACACCATTGCACTTCAACCTGGTCAACAGAGCGAGACTCCGTGTCAAAAAAA
AAAAAAAAAAAGTTTTCTGCCCTCAAGTCTTCTGGGGAGGCAGATGTTTAAACCAACAATTGCAGGCAGTAAGATTAGTGCTGATAGAAT
CATGCACATGCAGGATGCCATAGGAGCATGGGGAAGAGCACCCAAATATGGGAGAAAGGGGCAGAGGGACATTGTAAACATCAACCCTGC
AGTAGAAGACAGAGCAAAGCATGATTTCTCTTTTCTCTGGCCTGATTTAATTCTAAGGTCAGACGTTCAGCTTGATCATAACCTGTTTAT
AATTATGACTCAGACCATTTTTCCACTCTTGGATCATTGGCCATTAATGATGAGGGGTCTCAAACAACATGTCTCAGTGACACAGTAAAG
CAGAAATTGGCTGAAAGCAAAGCTGTTTTTATTTCTAGCTTCAGTCAGCACATAATGCTTAAAACCTAAAGAGGAAAGTAAAAGCGTGTT
ACAATCTCTCAAACTTTATCAAGACAGGGCTTAGAACCTGACATCCTCCGCTATGGTCATTCCATTTTGAAATGTAGAAAATCCAACTTG
TGGATGGTTTGTCTGTAAATGAGCTGAATGTGTGTGCGTGTTCATTATCAAGCACGATATGCTCACAAATGCACAGTACTTTAAGCCTTG
TGCAAGAAAGATGCTTTCAGTAAACATATTTAAAAGGTTTTATTTTCCTTACTAATGGTACATGCCCCTGCAAGTTCATGGAGAAGAGAA
AAACAAGTGTGGGTGAGCTGATGGAGGCTTCATCTTAGGTGAGGAGGCAGGAGAGACACCCTCCCTTCACTTGTGCCATCCCCACGCTTT
GTCCTTAAGCTGTAGTGGTCCCAGGAGATAACCTGTTTACAGCAGCCCATTCAGTATTGAAAAATGAACTCCCTCCTGCAGAATGTTAGA
AGAAACAACCTCAAAGACCTCAGGCCGCCTGTGGTCATTAGTATGTGGCAGCAAGATTGAACCTGCCTGCCTCCTACCTGTGTGAGCCTG
TGGTGTGGGTGTGGTACCAAGGCCCTGGCTCTGGGCAGTCTGTTGGCTCCTGGTGTTCACTAAGGCGTGGGGTGACAGGCCATCTGGCCT
CGCTCTGCCAGTCTGCAGTTCTCCCCAGCACTGCATTCATTTTTAGTGGTTTCTGATAGTCACACTGAATTCCTGGACACTTTCTTCTCT
TCATTCTTAGTTATCTTTCTCCTTTTTCTCCTGGAACTGATAGTTTACACTAAAACTTTTGGCTGTGAGGACTTGATTATACACATTTCT
AAAACCCATGAACCTTAATATCTGACACTGTTACTCTCATATGCACACACAACTAAAACATACCAACCTACTTCATTTCCTAGCTGCTAA
GATACAAGGGGAGGGACAATAAAAGGTTAACTGCAGAATAGCCACCTATGTGTCAGGAAATGGAGGGAGGGGAGGCAATGTGTGAGTCCT
TTTGGAGCTGGGACTCAATCCACAACAGAGACAGCTCAAGCAGGGCCCTGCCATGGTCCACACTGAGGTTTCCTCTGCAGTGGTGCTGTC
CACTGAGGGGTTATGGTGTGAGGGCCCCTGGGAGCCACGCCTTGGACTTCTGAGTCTGCAGAGCACTCGGCTCCAGCCAGCTGGATGGCA
GGTGGTCAGTGGAGCTGGTGACTGGTGGTTTCTGCAATGAGGTGTCAGATTAGCCTAAGGGAAGCCTCTTCAGCAAGTATCATGCCTGGA
TCCCGGTCTTGGTTGTTTTATGAGAGGCCGATATGAATTGCCATTGCCTCCCACAAAGAAAAATGGACAAAATATGGGACCACATCTTTG
AGATGAAATGTGCCCAAAATGAAAAGTAACTTGAGTATCCCAAGTTAAACTTAATCATTAGCTGCAAATGGACGATTTTCAAATTTCAAA
TAGTGATTTTTGAAGATTTGCCCAAACTAGAGTACTATCCCTCTTCACACTAAGAGGCAGAAAGTGGTTTCACACACCCTTTTATTTAAT
CAGCTAAAGTGGGTGCGGTGACACACACCTGTAAACTCAACCACTAAGGAGACTGAGGCGGGAGGATTACTTGAGCCCAGGAGTTCGAGA
TCAGCCTGAGCAACATAACAAGACCCTGTCTCAAATAATACTTAGCTATTACCCATATTGCTTTTAGCCTGCTGCCAGGAGGGGAGAAAT
GTTATTGTTTGAACAGATGTCAGATGTGAGTAATGCTCAGCTGTGTTCAATGTAGAAAATTAATAAAAGTTCCAGGAGTCATCCTGGCTA

>66183_66183_9_PLEKHA5-LSM3_PLEKHA5_chr12_19475516_ENST00000543806_LSM3_chr3_14223081_ENST00000306024_length(amino acids)=592AA_BP=
MTSEEKKERPISMINEASNYNVTSDYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNAPVVRRGWLYKQDSTGMKLWKKRWFVLSDLC
LFYYRDEKEEGILGSILLPSFQIALLTSEDHINRKYAFKAAHPNMRTYYFCTDTGKEMELWMKAMLDAALVQTEPVKRVDKITSENAPTK
ETNNIPNHRVLIKPEIQNNQKNKEMSKIEEKKALEAEKYGFQKDGQDRPLTKINSVKLNSLPSEYESGSACPAQTVHYRPINLSSSENKI
VNVSLADLRGGNRPNTGPLYTEADRVIQRTNSMQQLEQWIKIQKGRGHEEETRGVISYQTLPRNMPSHRAQIMARYPEGYRTLPRNSKTR
PESICSVTPSTHDKTLGPGAEEKRRSMRDDTMWQLYEWQQRQFYNKQSTLPRHSTLSSPKTMVNISDQTMHSIPTSPSHGSIAAYQGYSP
QRTYRSEVSSPIQRGDVTIDRRHRAHHPKHVYVPDRRSVPAGLTLQSVSPQSLQGKTMKENEPIITMVHTMIENSALRPQLYQQLSQDEG

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Fusion Gene PPI Analysis for PLEKHA5-LSM3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PLEKHA5-LSM3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PLEKHA5-LSM3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource