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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PLEKHG1-MTHFD1L (FusionGDB2 ID:66263)

Fusion Gene Summary for PLEKHG1-MTHFD1L

check button Fusion gene summary
Fusion gene informationFusion gene name: PLEKHG1-MTHFD1L
Fusion gene ID: 66263
HgeneTgene
Gene symbol

PLEKHG1

MTHFD1L

Gene ID

57480

25902

Gene namepleckstrin homology and RhoGEF domain containing G1methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like
SynonymsARHGEF41FTHFSDC1|MTC1THFS|dJ292B18.2
Cytomap

6q25.1

6q25.1

Type of geneprotein-codingprotein-coding
Descriptionpleckstrin homology domain-containing family G member 1pleckstrin homology domain containing, family G (with RhoGef domain) member 1monofunctional C1-tetrahydrofolate synthase, mitochondrial10-formyl-THF synthetaseformyltetrahydrofolate synthetase domain containing 1
Modification date2020031320200313
UniProtAcc.

Q6UB35

Ensembl transtripts involved in fusion geneENST00000358517, ENST00000367328, 
ENST00000367307, ENST00000478643, 
ENST00000367321, 
Fusion gene scores* DoF score11 X 11 X 10=121014 X 17 X 13=3094
# samples 1927
** MAII scorelog2(19/1210*10)=-2.67093572383101
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(27/3094*10)=-3.51844188439821
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PLEKHG1 [Title/Abstract] AND MTHFD1L [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPLEKHG1(150971922)-MTHFD1L(151355629), # samples:2
MTHFD1L(151358253)-PLEKHG1(150971864), # samples:1
Anticipated loss of major functional domain due to fusion event.PLEKHG1-MTHFD1L seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
PLEKHG1-MTHFD1L seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMTHFD1L

GO:0006760

folic acid-containing compound metabolic process

12937168

TgeneMTHFD1L

GO:0009257

10-formyltetrahydrofolate biosynthetic process

12937168

TgeneMTHFD1L

GO:0015942

formate metabolic process

16171773


check buttonFusion gene breakpoints across PLEKHG1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MTHFD1L (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-BT-A20W-01APLEKHG1chr6

151153341

+MTHFD1Lchr6

151277131

+
ChimerDB4LGGTCGA-E1-A7YNPLEKHG1chr6

151055228

+MTHFD1Lchr6

151198770

+
ChimerDB4LUADTCGA-44-2656-01APLEKHG1chr6

151107595

+MTHFD1Lchr6

151355629

+
ChimerDB4LUSCTCGA-34-A5IXPLEKHG1chr6

150971922

+MTHFD1Lchr6

151355629

+
ChimerDB4SKCMTCGA-ER-A42L-06APLEKHG1chr6

150971922

+MTHFD1Lchr6

151277131

+
ChimerDB4STADTCGA-BR-8591-01APLEKHG1chr6

151055228

+MTHFD1Lchr6

151413603

+
ChimerDB4STADTCGA-BR-8591PLEKHG1chr6

151055228

+MTHFD1Lchr6

151413602

+
ChimerDB4STADTCGA-VQ-A91A-01APLEKHG1chr6

150971922

+MTHFD1Lchr6

151355629

+


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Fusion Gene ORF analysis for PLEKHG1-MTHFD1L

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000358517ENST00000367307PLEKHG1chr6

151153341

+MTHFD1Lchr6

151277131

+
5CDS-intronENST00000358517ENST00000367307PLEKHG1chr6

151107595

+MTHFD1Lchr6

151355629

+
5CDS-intronENST00000358517ENST00000367307PLEKHG1chr6

151055228

+MTHFD1Lchr6

151413603

+
5CDS-intronENST00000358517ENST00000367307PLEKHG1chr6

151055228

+MTHFD1Lchr6

151413602

+
5CDS-intronENST00000358517ENST00000478643PLEKHG1chr6

151153341

+MTHFD1Lchr6

151277131

+
5CDS-intronENST00000358517ENST00000478643PLEKHG1chr6

151055228

+MTHFD1Lchr6

151198770

+
5CDS-intronENST00000358517ENST00000478643PLEKHG1chr6

151107595

+MTHFD1Lchr6

151355629

+
5CDS-intronENST00000358517ENST00000478643PLEKHG1chr6

151055228

+MTHFD1Lchr6

151413603

+
5CDS-intronENST00000358517ENST00000478643PLEKHG1chr6

151055228

+MTHFD1Lchr6

151413602

+
5CDS-intronENST00000367328ENST00000367307PLEKHG1chr6

151153341

+MTHFD1Lchr6

151277131

+
5CDS-intronENST00000367328ENST00000367307PLEKHG1chr6

151107595

+MTHFD1Lchr6

151355629

+
5CDS-intronENST00000367328ENST00000367307PLEKHG1chr6

151055228

+MTHFD1Lchr6

151413603

+
5CDS-intronENST00000367328ENST00000367307PLEKHG1chr6

151055228

+MTHFD1Lchr6

151413602

+
5CDS-intronENST00000367328ENST00000478643PLEKHG1chr6

151153341

+MTHFD1Lchr6

151277131

+
5CDS-intronENST00000367328ENST00000478643PLEKHG1chr6

151055228

+MTHFD1Lchr6

151198770

+
5CDS-intronENST00000367328ENST00000478643PLEKHG1chr6

151107595

+MTHFD1Lchr6

151355629

+
5CDS-intronENST00000367328ENST00000478643PLEKHG1chr6

151055228

+MTHFD1Lchr6

151413603

+
5CDS-intronENST00000367328ENST00000478643PLEKHG1chr6

151055228

+MTHFD1Lchr6

151413602

+
5UTR-3CDSENST00000367328ENST00000367321PLEKHG1chr6

150971922

+MTHFD1Lchr6

151355629

+
5UTR-3CDSENST00000367328ENST00000367321PLEKHG1chr6

150971922

+MTHFD1Lchr6

151277131

+
5UTR-intronENST00000367328ENST00000367307PLEKHG1chr6

150971922

+MTHFD1Lchr6

151355629

+
5UTR-intronENST00000367328ENST00000367307PLEKHG1chr6

150971922

+MTHFD1Lchr6

151277131

+
5UTR-intronENST00000367328ENST00000478643PLEKHG1chr6

150971922

+MTHFD1Lchr6

151355629

+
5UTR-intronENST00000367328ENST00000478643PLEKHG1chr6

150971922

+MTHFD1Lchr6

151277131

+
Frame-shiftENST00000358517ENST00000367321PLEKHG1chr6

151055228

+MTHFD1Lchr6

151413603

+
Frame-shiftENST00000358517ENST00000367321PLEKHG1chr6

151055228

+MTHFD1Lchr6

151413602

+
Frame-shiftENST00000367328ENST00000367321PLEKHG1chr6

151055228

+MTHFD1Lchr6

151413603

+
Frame-shiftENST00000367328ENST00000367321PLEKHG1chr6

151055228

+MTHFD1Lchr6

151413602

+
In-frameENST00000358517ENST00000367307PLEKHG1chr6

151055228

+MTHFD1Lchr6

151198770

+
In-frameENST00000358517ENST00000367321PLEKHG1chr6

151153341

+MTHFD1Lchr6

151277131

+
In-frameENST00000358517ENST00000367321PLEKHG1chr6

151055228

+MTHFD1Lchr6

151198770

+
In-frameENST00000358517ENST00000367321PLEKHG1chr6

151107595

+MTHFD1Lchr6

151355629

+
In-frameENST00000367328ENST00000367307PLEKHG1chr6

151055228

+MTHFD1Lchr6

151198770

+
In-frameENST00000367328ENST00000367321PLEKHG1chr6

151153341

+MTHFD1Lchr6

151277131

+
In-frameENST00000367328ENST00000367321PLEKHG1chr6

151055228

+MTHFD1Lchr6

151198770

+
In-frameENST00000367328ENST00000367321PLEKHG1chr6

151107595

+MTHFD1Lchr6

151355629

+
intron-3CDSENST00000358517ENST00000367321PLEKHG1chr6

150971922

+MTHFD1Lchr6

151355629

+
intron-3CDSENST00000358517ENST00000367321PLEKHG1chr6

150971922

+MTHFD1Lchr6

151277131

+
intron-intronENST00000358517ENST00000367307PLEKHG1chr6

150971922

+MTHFD1Lchr6

151355629

+
intron-intronENST00000358517ENST00000367307PLEKHG1chr6

150971922

+MTHFD1Lchr6

151277131

+
intron-intronENST00000358517ENST00000478643PLEKHG1chr6

150971922

+MTHFD1Lchr6

151355629

+
intron-intronENST00000358517ENST00000478643PLEKHG1chr6

150971922

+MTHFD1Lchr6

151277131

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000367328PLEKHG1chr6151153341+ENST00000367321MTHFD1Lchr6151277131+5010340622546161463
ENST00000358517PLEKHG1chr6151153341+ENST00000367321MTHFD1Lchr6151277131+490933055545151486
ENST00000367328PLEKHG1chr6151055228+ENST00000367321MTHFD1Lchr6151198770+374172322533471040
ENST00000367328PLEKHG1chr6151055228+ENST00000367307MTHFD1Lchr6151198770+12397232251238337
ENST00000358517PLEKHG1chr6151055228+ENST00000367321MTHFD1Lchr6151198770+36406225532461063
ENST00000358517PLEKHG1chr6151055228+ENST00000367307MTHFD1Lchr6151198770+1138622551137361
ENST00000367328PLEKHG1chr6151107595+ENST00000367321MTHFD1Lchr6151355629+16388942251244339
ENST00000358517PLEKHG1chr6151107595+ENST00000367321MTHFD1Lchr6151355629+1537793551143362

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000367328ENST00000367321PLEKHG1chr6151153341+MTHFD1Lchr6151277131+0.0010146830.99898535
ENST00000358517ENST00000367321PLEKHG1chr6151153341+MTHFD1Lchr6151277131+0.0008946880.9991053
ENST00000367328ENST00000367321PLEKHG1chr6151055228+MTHFD1Lchr6151198770+0.0010427440.9989573
ENST00000367328ENST00000367307PLEKHG1chr6151055228+MTHFD1Lchr6151198770+0.0049607810.99503917
ENST00000358517ENST00000367321PLEKHG1chr6151055228+MTHFD1Lchr6151198770+0.0009081630.99909186
ENST00000358517ENST00000367307PLEKHG1chr6151055228+MTHFD1Lchr6151198770+0.0034100830.9965899
ENST00000367328ENST00000367321PLEKHG1chr6151107595+MTHFD1Lchr6151355629+0.0022662890.9977337
ENST00000358517ENST00000367321PLEKHG1chr6151107595+MTHFD1Lchr6151355629+0.001507520.9984925

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Fusion Genomic Features for PLEKHG1-MTHFD1L


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PLEKHG1chr6150971922+MTHFD1Lchr6151277130+0.0159629420.98403704
PLEKHG1chr6151055228+MTHFD1Lchr6151413602+0.0010488370.9989511
PLEKHG1chr6151055228+MTHFD1Lchr6151413602+0.0010488370.9989511
PLEKHG1chr6151153341+MTHFD1Lchr6151277130+3.08E-050.99996924
PLEKHG1chr6151107595+MTHFD1Lchr6151355628+6.03E-060.9999939
PLEKHG1chr6150971922+MTHFD1Lchr6151355628+5.80E-060.99999416
PLEKHG1chr6150971922+MTHFD1Lchr6151355628+5.80E-060.99999416
PLEKHG1chr6151055228+MTHFD1Lchr6151198769+5.34E-060.99999464
PLEKHG1chr6150971922+MTHFD1Lchr6151277130+0.0159629420.98403704
PLEKHG1chr6151055228+MTHFD1Lchr6151413602+0.0010488370.9989511
PLEKHG1chr6151055228+MTHFD1Lchr6151413602+0.0010488370.9989511
PLEKHG1chr6151153341+MTHFD1Lchr6151277130+3.08E-050.99996924
PLEKHG1chr6151107595+MTHFD1Lchr6151355628+6.03E-060.9999939
PLEKHG1chr6150971922+MTHFD1Lchr6151355628+5.80E-060.99999416
PLEKHG1chr6150971922+MTHFD1Lchr6151355628+5.80E-060.99999416
PLEKHG1chr6151055228+MTHFD1Lchr6151198769+5.34E-060.99999464

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PLEKHG1-MTHFD1L


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:150971922/chr6:151355629)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MTHFD1L

Q6UB35

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2. {ECO:0000250, ECO:0000269|PubMed:16171773}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePLEKHG1chr6:151153341chr6:151277131ENST00000358517+1516113_29310311386.0DomainDH
HgenePLEKHG1chr6:151153341chr6:151277131ENST00000358517+1516317_41610311386.0DomainPH
HgenePLEKHG1chr6:151153341chr6:151277131ENST00000367328+1617113_29310311386.0DomainDH
HgenePLEKHG1chr6:151153341chr6:151277131ENST00000367328+1617317_41610311386.0DomainPH
TgeneMTHFD1Lchr6:151107595chr6:151355629ENST000003673070834_420276.0Compositional biasNote=Poly-Gly
TgeneMTHFD1Lchr6:151153341chr6:151277131ENST000003673070834_420276.0Compositional biasNote=Poly-Gly
TgeneMTHFD1Lchr6:151055228chr6:151198770ENST0000036730718423_430104276.0Nucleotide bindingATP
TgeneMTHFD1Lchr6:151055228chr6:151198770ENST00000367321128423_430104932.6666666666666Nucleotide bindingATP
TgeneMTHFD1Lchr6:151107595chr6:151355629ENST0000036730708423_4300276.0Nucleotide bindingATP
TgeneMTHFD1Lchr6:151153341chr6:151277131ENST0000036730708423_4300276.0Nucleotide bindingATP
TgeneMTHFD1Lchr6:151055228chr6:151198770ENST0000036730718349_978104276.0RegionNote=Formyltetrahydrofolate synthetase
TgeneMTHFD1Lchr6:151055228chr6:151198770ENST00000367321128349_978104932.6666666666666RegionNote=Formyltetrahydrofolate synthetase
TgeneMTHFD1Lchr6:151107595chr6:151355629ENST000003673070831_3480276.0RegionNote=Methylenetetrahydrofolate dehydrogenase and cyclohydrolase
TgeneMTHFD1Lchr6:151107595chr6:151355629ENST0000036730708349_9780276.0RegionNote=Formyltetrahydrofolate synthetase
TgeneMTHFD1Lchr6:151153341chr6:151277131ENST000003673070831_3480276.0RegionNote=Methylenetetrahydrofolate dehydrogenase and cyclohydrolase
TgeneMTHFD1Lchr6:151153341chr6:151277131ENST0000036730708349_9780276.0RegionNote=Formyltetrahydrofolate synthetase

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePLEKHG1chr6:151055228chr6:151198770ENST00000358517+216113_2931371386.0DomainDH
HgenePLEKHG1chr6:151055228chr6:151198770ENST00000358517+216317_4161371386.0DomainPH
HgenePLEKHG1chr6:151055228chr6:151198770ENST00000367328+317113_2931371386.0DomainDH
HgenePLEKHG1chr6:151055228chr6:151198770ENST00000367328+317317_4161371386.0DomainPH
HgenePLEKHG1chr6:151107595chr6:151355629ENST00000358517+416113_2931941386.0DomainDH
HgenePLEKHG1chr6:151107595chr6:151355629ENST00000358517+416317_4161941386.0DomainPH
HgenePLEKHG1chr6:151107595chr6:151355629ENST00000367328+517113_2931941386.0DomainDH
HgenePLEKHG1chr6:151107595chr6:151355629ENST00000367328+517317_4161941386.0DomainPH
TgeneMTHFD1Lchr6:151055228chr6:151198770ENST000003673071834_42104276.0Compositional biasNote=Poly-Gly
TgeneMTHFD1Lchr6:151055228chr6:151198770ENST0000036732112834_42104932.6666666666666Compositional biasNote=Poly-Gly
TgeneMTHFD1Lchr6:151107595chr6:151355629ENST00000367321232834_42862932.6666666666666Compositional biasNote=Poly-Gly
TgeneMTHFD1Lchr6:151153341chr6:151277131ENST00000367321152834_42575932.6666666666666Compositional biasNote=Poly-Gly
TgeneMTHFD1Lchr6:151107595chr6:151355629ENST000003673212328423_430862932.6666666666666Nucleotide bindingATP
TgeneMTHFD1Lchr6:151153341chr6:151277131ENST000003673211528423_430575932.6666666666666Nucleotide bindingATP
TgeneMTHFD1Lchr6:151055228chr6:151198770ENST000003673071831_348104276.0RegionNote=Methylenetetrahydrofolate dehydrogenase and cyclohydrolase
TgeneMTHFD1Lchr6:151055228chr6:151198770ENST0000036732112831_348104932.6666666666666RegionNote=Methylenetetrahydrofolate dehydrogenase and cyclohydrolase
TgeneMTHFD1Lchr6:151107595chr6:151355629ENST00000367321232831_348862932.6666666666666RegionNote=Methylenetetrahydrofolate dehydrogenase and cyclohydrolase
TgeneMTHFD1Lchr6:151107595chr6:151355629ENST000003673212328349_978862932.6666666666666RegionNote=Formyltetrahydrofolate synthetase
TgeneMTHFD1Lchr6:151153341chr6:151277131ENST00000367321152831_348575932.6666666666666RegionNote=Methylenetetrahydrofolate dehydrogenase and cyclohydrolase
TgeneMTHFD1Lchr6:151153341chr6:151277131ENST000003673211528349_978575932.6666666666666RegionNote=Formyltetrahydrofolate synthetase


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Fusion Gene Sequence for PLEKHG1-MTHFD1L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>66263_66263_1_PLEKHG1-MTHFD1L_PLEKHG1_chr6_151055228_ENST00000358517_MTHFD1L_chr6_151198770_ENST00000367307_length(transcript)=1138nt_BP=622nt
AATATTTCTACGGAAGGCGCTGCACAGACTAGCAAAGGCTGTTTCTTTTACCTGACTGAGGTCACTGCATCAGCTGAAGGCAGACGATGT
GCTTAAGCCTGAGTGGAGCAGAGATGGGCACCAGTTGCGTCTTGAAGTGCCATCAGCTGTAACCAAAGTTCCACATCCCAAGACGACAGC
CAGGCGTTCCTGCCCTCAAGAACTGAAGACAATGGAGCTCTCTGATAGTGACCGACCCGTCAGCTTCGGTTCCACATCATCCTCGGCCTC
TTCCCGCGACAGCCATGGTTCCTTCGGCAGCAGAATGACCTTAGTTTCAAATAGCCACATGGGCTTGTTTAACCAGGATAAGGAGGTAGG
GGCCATAAAACTGGAGCTGATTCCTGCCAGGCCGTTTTCCAGCAGCGAGCTGCAGAGGGACAACCCCGCCACGGGGCAACAGAACGCGGA
TGAGGGCAGCGAAAGGCCACCCAGAGCGCAGTGGAGAGTGGACTCAAACGGGGCACCCAAGACGATCGCAGACTCGGCCACGAGCCCCAA
GCTCCTCTATGTGGATAGAGTTGTTCAGGAAATTCTGGAAACCGAAAGGACTTATGTACAAGATTTAAAAAGCATCGTAGAGGCAGGTGA
CGACAACTTGATGCAGGAAATCAACCAGAATTTGGCTGAGGAGGCTGGTCTGAACATCACTCACATTTGCCTCCCTCCAGATAGCAGTGA
AGCCGAGATTATAGATGAAATCTTAAAGATCAATGAAGATACCAGAGTACATGGCCTTGCCCTTCAGATCTCTGAGAACTTGTTTAGCAA
CAAAGTCCTCAATGCCTTGAAACCAGAAAAAGATGTGGATGGAGTAACAGACATAAACCTGGGGAAGCTGGTGCGAGGGGATGCCCATGA
ATGTTTTGTTTCACCTGTTGCCAAAGCTGTAATTGAACTTCTTGAAAAATCAGGTGTCAACCTAGATGGAAAGAAGATTTTGGTAGTGGG
GGCCCATGGGTCTTTGGAAGCTGCTCTACAATGCCTGTTCCAGAGAAAAGGGTCCATGACAATGAGCATCCAGTGGAAAACACGCCAGCT

>66263_66263_1_PLEKHG1-MTHFD1L_PLEKHG1_chr6_151055228_ENST00000358517_MTHFD1L_chr6_151198770_ENST00000367307_length(amino acids)=361AA_BP=1
MRSLHQLKADDVLKPEWSRDGHQLRLEVPSAVTKVPHPKTTARRSCPQELKTMELSDSDRPVSFGSTSSSASSRDSHGSFGSRMTLVSNS
HMGLFNQDKEVGAIKLELIPARPFSSSELQRDNPATGQQNADEGSERPPRAQWRVDSNGAPKTIADSATSPKLLYVDRVVQEILETERTY
VQDLKSIVEAGDDNLMQEINQNLAEEAGLNITHICLPPDSSEAEIIDEILKINEDTRVHGLALQISENLFSNKVLNALKPEKDVDGVTDI
NLGKLVRGDAHECFVSPVAKAVIELLEKSGVNLDGKKILVVGAHGSLEAALQCLFQRKGSMTMSIQWKTRQLQSKTESRSVTRLECRRVI

--------------------------------------------------------------
>66263_66263_2_PLEKHG1-MTHFD1L_PLEKHG1_chr6_151055228_ENST00000358517_MTHFD1L_chr6_151198770_ENST00000367321_length(transcript)=3640nt_BP=622nt
AATATTTCTACGGAAGGCGCTGCACAGACTAGCAAAGGCTGTTTCTTTTACCTGACTGAGGTCACTGCATCAGCTGAAGGCAGACGATGT
GCTTAAGCCTGAGTGGAGCAGAGATGGGCACCAGTTGCGTCTTGAAGTGCCATCAGCTGTAACCAAAGTTCCACATCCCAAGACGACAGC
CAGGCGTTCCTGCCCTCAAGAACTGAAGACAATGGAGCTCTCTGATAGTGACCGACCCGTCAGCTTCGGTTCCACATCATCCTCGGCCTC
TTCCCGCGACAGCCATGGTTCCTTCGGCAGCAGAATGACCTTAGTTTCAAATAGCCACATGGGCTTGTTTAACCAGGATAAGGAGGTAGG
GGCCATAAAACTGGAGCTGATTCCTGCCAGGCCGTTTTCCAGCAGCGAGCTGCAGAGGGACAACCCCGCCACGGGGCAACAGAACGCGGA
TGAGGGCAGCGAAAGGCCACCCAGAGCGCAGTGGAGAGTGGACTCAAACGGGGCACCCAAGACGATCGCAGACTCGGCCACGAGCCCCAA
GCTCCTCTATGTGGATAGAGTTGTTCAGGAAATTCTGGAAACCGAAAGGACTTATGTACAAGATTTAAAAAGCATCGTAGAGGCAGGTGA
CGACAACTTGATGCAGGAAATCAACCAGAATTTGGCTGAGGAGGCTGGTCTGAACATCACTCACATTTGCCTCCCTCCAGATAGCAGTGA
AGCCGAGATTATAGATGAAATCTTAAAGATCAATGAAGATACCAGAGTACATGGCCTTGCCCTTCAGATCTCTGAGAACTTGTTTAGCAA
CAAAGTCCTCAATGCCTTGAAACCAGAAAAAGATGTGGATGGAGTAACAGACATAAACCTGGGGAAGCTGGTGCGAGGGGATGCCCATGA
ATGTTTTGTTTCACCTGTTGCCAAAGCTGTAATTGAACTTCTTGAAAAATCAGGTGTCAACCTAGATGGAAAGAAGATTTTGGTAGTGGG
GGCCCATGGGTCTTTGGAAGCTGCTCTACAATGCCTGTTCCAGAGAAAAGGGTCCATGACAATGAGCATCCAGTGGAAAACACGCCAGCT
TCAAAGCAAGCTTCACGAGGCTGACATTGTGGTCCTAGGCTCACCTAAGCCAGAAGAGATTCCCCTTACTTGGATACAACCAGGAACTAC
TGTTCTCAACTGCTCCCATGACTTCCTGTCAGGGAAGGTTGGGTGTGGCTCTCCAAGAATACATTTTGGTGGACTCATTGAGGAAGATGA
TGTGATTCTCCTTGCTGCAGCTCTGCGAATTCAGAACATGGTCAGTAGTGGAAGGAGATGGCTTCGTGAACAGCAGCACAGGCGGTGGAG
ACTTCACTGCTTGAAACTTCAGCCTCTCTCCCCTGTGCCAAGTGACATTGAGATTTCAAGAGGACAAACTCCAAAAGCTGTGGATGTCCT
TGCCAAGGAGATTGGATTGCTTGCAGATGAAATTGAAATCTATGGCAAAAGCAAAGCCAAAGTACGTTTGTCCGTGCTAGAAAGGTTAAA
GGATCAAGCAGATGGAAAATACGTCTTAGTTGCTGGGATCACACCCACCCCTCTTGGAGAAGGGAAGAGCACAGTCACCATCGGGCTTGT
GCAGGCTCTGACCGCACACCTGAATGTCAACTCCTTTGCCTGCTTGAGGCAGCCTTCCCAAGGACCGACGTTTGGAGTGAAAGGAGGAGC
CGCGGGTGGTGGATATGCCCAGGTCATCCCCATGGAGGAGTTCAACCTTCACTTGACTGGAGACATCCACGCCATCACCGCTGCCAATAA
CTTGCTGGCTGCCGCCATCGACACGAGGATTCTTCATGAAAACACGCAAACAGATAAGGCTCTGTATAATCGGCTGGTTCCTTTAGTGAA
TGGTGTCAGAGAATTTTCAGAAATTCAGCTTGCTCGGCTAAAAAAACTGGGAATAAATAAGACTGATCCGAGCACACTGACAGAAGAGGA
AGTGAGTAAATTTGCCCGTCTCGACATCGACCCATCTACCATCACGTGGCAGAGAGTATTGGATACAAATGACCGATTTCTACGAAAAAT
AACCATCGGGCAGGGAAACACAGAGAAGGGCCATTACCGGCAGGCGCAGTTTGACATCGCAGTGGCCAGCGAGATCATGGCGGTGCTGGC
CCTGACGGACAGCCTCGCAGACATGAAGGCACGGCTGGGAAGGATGGTGGTGGCCAGTGACAAAAGCGGGCAGCCTGTGACAGCAGATGA
TTTGGGGGTGACAGGTGCTTTGACAGTTTTGATGAAAGATGCAATAAAACCAAACCTGATGCAGACCCTGGAAGGGACACCTGTGTTCGT
GCATGCGGGCCCTTTTGCTAACATTGCTCACGGCAACTCTTCAGTGTTGGCTGATAAAATTGCCCTGAAACTGGTTGGTGAAGAAGGATT
TGTAGTGACCGAAGCTGGCTTTGGTGCTGACATCGGAATGGAGAAATTCTTCAACATCAAGTGCCGAGCTTCCGGCTTGGTGCCCAACGT
GGTTGTGTTAGTGGCAACGGTGCGAGCTCTGAAGATGCATGGAGGCGGGCCAAGTGTAACGGCTGGTGTTCCTCTTAAGAAAGAATATAC
AGAGGAGAACATCCAGCTGGTGGCAGACGGCTGCTGTAACCTCCAGAAGCAAATTCAGATCACTCAGCTCTTTGGGGTTCCCGTTGTGGT
GGCTCTGAATGTCTTCAAGACCGACACCCGCGCTGAGATTGACTTGGTGTGTGAGCTTGCAAAGCGGGCTGGTGCCTTTGATGCAGTCCC
CTGCTATCACTGGTCCGTTGGTGGAAAAGGATCGGTGGACTTGGCTCGGGCTGTGAGAGAGGCTGCGAGTAAAAGAAGCCGATTCCAGTT
CCTGTATGATGTTCAGGTTCCAATTGTGGACAAGATAAGGACCATTGCTCAGGCTGTCTATGGAGCCAAAGATATTGAACTCTCTCCTGA
GGCACAAGCCAAAATAGATCGTTACACTCAACAGGGTTTTGGAAATTTGCCCATCTGCATGGCAAAGACCCACCTTTCTCTATCTCACCA
ACCTGACAAAAAAGGTGTGCCAAGGGACTTCATCTTACCTATCAGTGACGTCCGGGCCAGCATAGGCGCTGGGTTCATTTACCCTTTGGT
CGGAACGATGAGCACCATGCCAGGACTGCCCACCCGGCCCTGCTTTTATGACATAGATCTTGATACCGAAACAGAACAAGTTAAAGGCTT
GTTCTAAGTGGACAAGGCTCTCACAGGACCCGATGCAGACTCCTGAAACAGACTACTCTTTGCCTTTTTGCTGCAGTTGGAGAAGAAACT
GAATTTGAAAAATGTCTGTTATGCAATGCTGGAGACATGGTGAAATAGGCCAAAGATTTCTTCTTCGTTCAAGATGAATTCTGTTCACAG
TGGAGTATGGTGTTCGGCAAAAGGACCTCCACCAAGACTGAAAGAAACTAATTTATTTCTGTTTCTGTGGAGTTTCCATTATTTCTACTG
CTTACACTTTAGAATGTTTATTTTATGGGGACTAAGGGATTAGGAGTGTGAACTAAAAGGTAACATTTTCCACTCTCAAGTTTTCTACTT

>66263_66263_2_PLEKHG1-MTHFD1L_PLEKHG1_chr6_151055228_ENST00000358517_MTHFD1L_chr6_151198770_ENST00000367321_length(amino acids)=1063AA_BP=1
MRSLHQLKADDVLKPEWSRDGHQLRLEVPSAVTKVPHPKTTARRSCPQELKTMELSDSDRPVSFGSTSSSASSRDSHGSFGSRMTLVSNS
HMGLFNQDKEVGAIKLELIPARPFSSSELQRDNPATGQQNADEGSERPPRAQWRVDSNGAPKTIADSATSPKLLYVDRVVQEILETERTY
VQDLKSIVEAGDDNLMQEINQNLAEEAGLNITHICLPPDSSEAEIIDEILKINEDTRVHGLALQISENLFSNKVLNALKPEKDVDGVTDI
NLGKLVRGDAHECFVSPVAKAVIELLEKSGVNLDGKKILVVGAHGSLEAALQCLFQRKGSMTMSIQWKTRQLQSKLHEADIVVLGSPKPE
EIPLTWIQPGTTVLNCSHDFLSGKVGCGSPRIHFGGLIEEDDVILLAAALRIQNMVSSGRRWLREQQHRRWRLHCLKLQPLSPVPSDIEI
SRGQTPKAVDVLAKEIGLLADEIEIYGKSKAKVRLSVLERLKDQADGKYVLVAGITPTPLGEGKSTVTIGLVQALTAHLNVNSFACLRQP
SQGPTFGVKGGAAGGGYAQVIPMEEFNLHLTGDIHAITAANNLLAAAIDTRILHENTQTDKALYNRLVPLVNGVREFSEIQLARLKKLGI
NKTDPSTLTEEEVSKFARLDIDPSTITWQRVLDTNDRFLRKITIGQGNTEKGHYRQAQFDIAVASEIMAVLALTDSLADMKARLGRMVVA
SDKSGQPVTADDLGVTGALTVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSVLADKIALKLVGEEGFVVTEAGFGADIGMEKFFN
IKCRASGLVPNVVVLVATVRALKMHGGGPSVTAGVPLKKEYTEENIQLVADGCCNLQKQIQITQLFGVPVVVALNVFKTDTRAEIDLVCE
LAKRAGAFDAVPCYHWSVGGKGSVDLARAVREAASKRSRFQFLYDVQVPIVDKIRTIAQAVYGAKDIELSPEAQAKIDRYTQQGFGNLPI

--------------------------------------------------------------
>66263_66263_3_PLEKHG1-MTHFD1L_PLEKHG1_chr6_151055228_ENST00000367328_MTHFD1L_chr6_151198770_ENST00000367307_length(transcript)=1239nt_BP=723nt
GAGGAAGAGGAAGTCGGAGCCCGAGCCTGAGCCCGAGCCCGAGCCCGACGGCGGCTGCAGGGCGCTCCGGCAGCCCGAGCCGGCGCAGCG
CAGCCCGCACCCTCCCCGCCCGACCTGCGAGCGCCGCCCGGGCATGCGAAGCCGTCCCTCCCCGGGTGAAGACTGATGAGAAGAGTCTGT
GGGTGAAGACATTGAAAAGGTTTCAACTATAAAAATGGGCACCAGTTGCGTCTTGAAGTGCCATCAGCTGTAACCAAAGTTCCACATCCC
AAGACGACAGCCAGGCGTTCCTGCCCTCAAGAACTGAAGACAATGGAGCTCTCTGATAGTGACCGACCCGTCAGCTTCGGTTCCACATCA
TCCTCGGCCTCTTCCCGCGACAGCCATGGTTCCTTCGGCAGCAGAATGACCTTAGTTTCAAATAGCCACATGGGCTTGTTTAACCAGGAT
AAGGAGGTAGGGGCCATAAAACTGGAGCTGATTCCTGCCAGGCCGTTTTCCAGCAGCGAGCTGCAGAGGGACAACCCCGCCACGGGGCAA
CAGAACGCGGATGAGGGCAGCGAAAGGCCACCCAGAGCGCAGTGGAGAGTGGACTCAAACGGGGCACCCAAGACGATCGCAGACTCGGCC
ACGAGCCCCAAGCTCCTCTATGTGGATAGAGTTGTTCAGGAAATTCTGGAAACCGAAAGGACTTATGTACAAGATTTAAAAAGCATCGTA
GAGGCAGGTGACGACAACTTGATGCAGGAAATCAACCAGAATTTGGCTGAGGAGGCTGGTCTGAACATCACTCACATTTGCCTCCCTCCA
GATAGCAGTGAAGCCGAGATTATAGATGAAATCTTAAAGATCAATGAAGATACCAGAGTACATGGCCTTGCCCTTCAGATCTCTGAGAAC
TTGTTTAGCAACAAAGTCCTCAATGCCTTGAAACCAGAAAAAGATGTGGATGGAGTAACAGACATAAACCTGGGGAAGCTGGTGCGAGGG
GATGCCCATGAATGTTTTGTTTCACCTGTTGCCAAAGCTGTAATTGAACTTCTTGAAAAATCAGGTGTCAACCTAGATGGAAAGAAGATT
TTGGTAGTGGGGGCCCATGGGTCTTTGGAAGCTGCTCTACAATGCCTGTTCCAGAGAAAAGGGTCCATGACAATGAGCATCCAGTGGAAA

>66263_66263_3_PLEKHG1-MTHFD1L_PLEKHG1_chr6_151055228_ENST00000367328_MTHFD1L_chr6_151198770_ENST00000367307_length(amino acids)=337AA_BP=1
MRLEVPSAVTKVPHPKTTARRSCPQELKTMELSDSDRPVSFGSTSSSASSRDSHGSFGSRMTLVSNSHMGLFNQDKEVGAIKLELIPARP
FSSSELQRDNPATGQQNADEGSERPPRAQWRVDSNGAPKTIADSATSPKLLYVDRVVQEILETERTYVQDLKSIVEAGDDNLMQEINQNL
AEEAGLNITHICLPPDSSEAEIIDEILKINEDTRVHGLALQISENLFSNKVLNALKPEKDVDGVTDINLGKLVRGDAHECFVSPVAKAVI

--------------------------------------------------------------
>66263_66263_4_PLEKHG1-MTHFD1L_PLEKHG1_chr6_151055228_ENST00000367328_MTHFD1L_chr6_151198770_ENST00000367321_length(transcript)=3741nt_BP=723nt
GAGGAAGAGGAAGTCGGAGCCCGAGCCTGAGCCCGAGCCCGAGCCCGACGGCGGCTGCAGGGCGCTCCGGCAGCCCGAGCCGGCGCAGCG
CAGCCCGCACCCTCCCCGCCCGACCTGCGAGCGCCGCCCGGGCATGCGAAGCCGTCCCTCCCCGGGTGAAGACTGATGAGAAGAGTCTGT
GGGTGAAGACATTGAAAAGGTTTCAACTATAAAAATGGGCACCAGTTGCGTCTTGAAGTGCCATCAGCTGTAACCAAAGTTCCACATCCC
AAGACGACAGCCAGGCGTTCCTGCCCTCAAGAACTGAAGACAATGGAGCTCTCTGATAGTGACCGACCCGTCAGCTTCGGTTCCACATCA
TCCTCGGCCTCTTCCCGCGACAGCCATGGTTCCTTCGGCAGCAGAATGACCTTAGTTTCAAATAGCCACATGGGCTTGTTTAACCAGGAT
AAGGAGGTAGGGGCCATAAAACTGGAGCTGATTCCTGCCAGGCCGTTTTCCAGCAGCGAGCTGCAGAGGGACAACCCCGCCACGGGGCAA
CAGAACGCGGATGAGGGCAGCGAAAGGCCACCCAGAGCGCAGTGGAGAGTGGACTCAAACGGGGCACCCAAGACGATCGCAGACTCGGCC
ACGAGCCCCAAGCTCCTCTATGTGGATAGAGTTGTTCAGGAAATTCTGGAAACCGAAAGGACTTATGTACAAGATTTAAAAAGCATCGTA
GAGGCAGGTGACGACAACTTGATGCAGGAAATCAACCAGAATTTGGCTGAGGAGGCTGGTCTGAACATCACTCACATTTGCCTCCCTCCA
GATAGCAGTGAAGCCGAGATTATAGATGAAATCTTAAAGATCAATGAAGATACCAGAGTACATGGCCTTGCCCTTCAGATCTCTGAGAAC
TTGTTTAGCAACAAAGTCCTCAATGCCTTGAAACCAGAAAAAGATGTGGATGGAGTAACAGACATAAACCTGGGGAAGCTGGTGCGAGGG
GATGCCCATGAATGTTTTGTTTCACCTGTTGCCAAAGCTGTAATTGAACTTCTTGAAAAATCAGGTGTCAACCTAGATGGAAAGAAGATT
TTGGTAGTGGGGGCCCATGGGTCTTTGGAAGCTGCTCTACAATGCCTGTTCCAGAGAAAAGGGTCCATGACAATGAGCATCCAGTGGAAA
ACACGCCAGCTTCAAAGCAAGCTTCACGAGGCTGACATTGTGGTCCTAGGCTCACCTAAGCCAGAAGAGATTCCCCTTACTTGGATACAA
CCAGGAACTACTGTTCTCAACTGCTCCCATGACTTCCTGTCAGGGAAGGTTGGGTGTGGCTCTCCAAGAATACATTTTGGTGGACTCATT
GAGGAAGATGATGTGATTCTCCTTGCTGCAGCTCTGCGAATTCAGAACATGGTCAGTAGTGGAAGGAGATGGCTTCGTGAACAGCAGCAC
AGGCGGTGGAGACTTCACTGCTTGAAACTTCAGCCTCTCTCCCCTGTGCCAAGTGACATTGAGATTTCAAGAGGACAAACTCCAAAAGCT
GTGGATGTCCTTGCCAAGGAGATTGGATTGCTTGCAGATGAAATTGAAATCTATGGCAAAAGCAAAGCCAAAGTACGTTTGTCCGTGCTA
GAAAGGTTAAAGGATCAAGCAGATGGAAAATACGTCTTAGTTGCTGGGATCACACCCACCCCTCTTGGAGAAGGGAAGAGCACAGTCACC
ATCGGGCTTGTGCAGGCTCTGACCGCACACCTGAATGTCAACTCCTTTGCCTGCTTGAGGCAGCCTTCCCAAGGACCGACGTTTGGAGTG
AAAGGAGGAGCCGCGGGTGGTGGATATGCCCAGGTCATCCCCATGGAGGAGTTCAACCTTCACTTGACTGGAGACATCCACGCCATCACC
GCTGCCAATAACTTGCTGGCTGCCGCCATCGACACGAGGATTCTTCATGAAAACACGCAAACAGATAAGGCTCTGTATAATCGGCTGGTT
CCTTTAGTGAATGGTGTCAGAGAATTTTCAGAAATTCAGCTTGCTCGGCTAAAAAAACTGGGAATAAATAAGACTGATCCGAGCACACTG
ACAGAAGAGGAAGTGAGTAAATTTGCCCGTCTCGACATCGACCCATCTACCATCACGTGGCAGAGAGTATTGGATACAAATGACCGATTT
CTACGAAAAATAACCATCGGGCAGGGAAACACAGAGAAGGGCCATTACCGGCAGGCGCAGTTTGACATCGCAGTGGCCAGCGAGATCATG
GCGGTGCTGGCCCTGACGGACAGCCTCGCAGACATGAAGGCACGGCTGGGAAGGATGGTGGTGGCCAGTGACAAAAGCGGGCAGCCTGTG
ACAGCAGATGATTTGGGGGTGACAGGTGCTTTGACAGTTTTGATGAAAGATGCAATAAAACCAAACCTGATGCAGACCCTGGAAGGGACA
CCTGTGTTCGTGCATGCGGGCCCTTTTGCTAACATTGCTCACGGCAACTCTTCAGTGTTGGCTGATAAAATTGCCCTGAAACTGGTTGGT
GAAGAAGGATTTGTAGTGACCGAAGCTGGCTTTGGTGCTGACATCGGAATGGAGAAATTCTTCAACATCAAGTGCCGAGCTTCCGGCTTG
GTGCCCAACGTGGTTGTGTTAGTGGCAACGGTGCGAGCTCTGAAGATGCATGGAGGCGGGCCAAGTGTAACGGCTGGTGTTCCTCTTAAG
AAAGAATATACAGAGGAGAACATCCAGCTGGTGGCAGACGGCTGCTGTAACCTCCAGAAGCAAATTCAGATCACTCAGCTCTTTGGGGTT
CCCGTTGTGGTGGCTCTGAATGTCTTCAAGACCGACACCCGCGCTGAGATTGACTTGGTGTGTGAGCTTGCAAAGCGGGCTGGTGCCTTT
GATGCAGTCCCCTGCTATCACTGGTCCGTTGGTGGAAAAGGATCGGTGGACTTGGCTCGGGCTGTGAGAGAGGCTGCGAGTAAAAGAAGC
CGATTCCAGTTCCTGTATGATGTTCAGGTTCCAATTGTGGACAAGATAAGGACCATTGCTCAGGCTGTCTATGGAGCCAAAGATATTGAA
CTCTCTCCTGAGGCACAAGCCAAAATAGATCGTTACACTCAACAGGGTTTTGGAAATTTGCCCATCTGCATGGCAAAGACCCACCTTTCT
CTATCTCACCAACCTGACAAAAAAGGTGTGCCAAGGGACTTCATCTTACCTATCAGTGACGTCCGGGCCAGCATAGGCGCTGGGTTCATT
TACCCTTTGGTCGGAACGATGAGCACCATGCCAGGACTGCCCACCCGGCCCTGCTTTTATGACATAGATCTTGATACCGAAACAGAACAA
GTTAAAGGCTTGTTCTAAGTGGACAAGGCTCTCACAGGACCCGATGCAGACTCCTGAAACAGACTACTCTTTGCCTTTTTGCTGCAGTTG
GAGAAGAAACTGAATTTGAAAAATGTCTGTTATGCAATGCTGGAGACATGGTGAAATAGGCCAAAGATTTCTTCTTCGTTCAAGATGAAT
TCTGTTCACAGTGGAGTATGGTGTTCGGCAAAAGGACCTCCACCAAGACTGAAAGAAACTAATTTATTTCTGTTTCTGTGGAGTTTCCAT
TATTTCTACTGCTTACACTTTAGAATGTTTATTTTATGGGGACTAAGGGATTAGGAGTGTGAACTAAAAGGTAACATTTTCCACTCTCAA

>66263_66263_4_PLEKHG1-MTHFD1L_PLEKHG1_chr6_151055228_ENST00000367328_MTHFD1L_chr6_151198770_ENST00000367321_length(amino acids)=1040AA_BP=1
MRLEVPSAVTKVPHPKTTARRSCPQELKTMELSDSDRPVSFGSTSSSASSRDSHGSFGSRMTLVSNSHMGLFNQDKEVGAIKLELIPARP
FSSSELQRDNPATGQQNADEGSERPPRAQWRVDSNGAPKTIADSATSPKLLYVDRVVQEILETERTYVQDLKSIVEAGDDNLMQEINQNL
AEEAGLNITHICLPPDSSEAEIIDEILKINEDTRVHGLALQISENLFSNKVLNALKPEKDVDGVTDINLGKLVRGDAHECFVSPVAKAVI
ELLEKSGVNLDGKKILVVGAHGSLEAALQCLFQRKGSMTMSIQWKTRQLQSKLHEADIVVLGSPKPEEIPLTWIQPGTTVLNCSHDFLSG
KVGCGSPRIHFGGLIEEDDVILLAAALRIQNMVSSGRRWLREQQHRRWRLHCLKLQPLSPVPSDIEISRGQTPKAVDVLAKEIGLLADEI
EIYGKSKAKVRLSVLERLKDQADGKYVLVAGITPTPLGEGKSTVTIGLVQALTAHLNVNSFACLRQPSQGPTFGVKGGAAGGGYAQVIPM
EEFNLHLTGDIHAITAANNLLAAAIDTRILHENTQTDKALYNRLVPLVNGVREFSEIQLARLKKLGINKTDPSTLTEEEVSKFARLDIDP
STITWQRVLDTNDRFLRKITIGQGNTEKGHYRQAQFDIAVASEIMAVLALTDSLADMKARLGRMVVASDKSGQPVTADDLGVTGALTVLM
KDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSVLADKIALKLVGEEGFVVTEAGFGADIGMEKFFNIKCRASGLVPNVVVLVATVRALK
MHGGGPSVTAGVPLKKEYTEENIQLVADGCCNLQKQIQITQLFGVPVVVALNVFKTDTRAEIDLVCELAKRAGAFDAVPCYHWSVGGKGS
VDLARAVREAASKRSRFQFLYDVQVPIVDKIRTIAQAVYGAKDIELSPEAQAKIDRYTQQGFGNLPICMAKTHLSLSHQPDKKGVPRDFI

--------------------------------------------------------------
>66263_66263_5_PLEKHG1-MTHFD1L_PLEKHG1_chr6_151107595_ENST00000358517_MTHFD1L_chr6_151355629_ENST00000367321_length(transcript)=1537nt_BP=793nt
AATATTTCTACGGAAGGCGCTGCACAGACTAGCAAAGGCTGTTTCTTTTACCTGACTGAGGTCACTGCATCAGCTGAAGGCAGACGATGT
GCTTAAGCCTGAGTGGAGCAGAGATGGGCACCAGTTGCGTCTTGAAGTGCCATCAGCTGTAACCAAAGTTCCACATCCCAAGACGACAGC
CAGGCGTTCCTGCCCTCAAGAACTGAAGACAATGGAGCTCTCTGATAGTGACCGACCCGTCAGCTTCGGTTCCACATCATCCTCGGCCTC
TTCCCGCGACAGCCATGGTTCCTTCGGCAGCAGAATGACCTTAGTTTCAAATAGCCACATGGGCTTGTTTAACCAGGATAAGGAGGTAGG
GGCCATAAAACTGGAGCTGATTCCTGCCAGGCCGTTTTCCAGCAGCGAGCTGCAGAGGGACAACCCCGCCACGGGGCAACAGAACGCGGA
TGAGGGCAGCGAAAGGCCACCCAGAGCGCAGTGGAGAGTGGACTCAAACGGGGCACCCAAGACGATCGCAGACTCGGCCACGAGCCCCAA
GCTCCTCTATGTGGATAGAGTTGTTCAGGAAATTCTGGAAACCGAAAGGACTTATGTACAAGATTTAAAAAGCATCGTAGAGGATTACCT
TGACTGCATCAGGGACCAAACAAAACTTCCCCTGGGGACCGAAGAAAGATCAGCCCTTTTTGGAAACATACAGGATATCTACCACTTCAA
TAGTGAACTTCTGCAAGATTTGGAAAACTGTGAAAATGATCCTGTGGCCATAGCAGAGTGTTTTGTGTCCAAGGTTCCAATTGTGGACAA
GATAAGGACCATTGCTCAGGCTGTCTATGGAGCCAAAGATATTGAACTCTCTCCTGAGGCACAAGCCAAAATAGATCGTTACACTCAACA
GGGTTTTGGAAATTTGCCCATCTGCATGGCAAAGACCCACCTTTCTCTATCTCACCAACCTGACAAAAAAGGTGTGCCAAGGGACTTCAT
CTTACCTATCAGTGACGTCCGGGCCAGCATAGGCGCTGGGTTCATTTACCCTTTGGTCGGAACGATGAGCACCATGCCAGGACTGCCCAC
CCGGCCCTGCTTTTATGACATAGATCTTGATACCGAAACAGAACAAGTTAAAGGCTTGTTCTAAGTGGACAAGGCTCTCACAGGACCCGA
TGCAGACTCCTGAAACAGACTACTCTTTGCCTTTTTGCTGCAGTTGGAGAAGAAACTGAATTTGAAAAATGTCTGTTATGCAATGCTGGA
GACATGGTGAAATAGGCCAAAGATTTCTTCTTCGTTCAAGATGAATTCTGTTCACAGTGGAGTATGGTGTTCGGCAAAAGGACCTCCACC
AAGACTGAAAGAAACTAATTTATTTCTGTTTCTGTGGAGTTTCCATTATTTCTACTGCTTACACTTTAGAATGTTTATTTTATGGGGACT
AAGGGATTAGGAGTGTGAACTAAAAGGTAACATTTTCCACTCTCAAGTTTTCTACTTTGTCTTTGAACTGAAAATAAACATGGATCTAGA

>66263_66263_5_PLEKHG1-MTHFD1L_PLEKHG1_chr6_151107595_ENST00000358517_MTHFD1L_chr6_151355629_ENST00000367321_length(amino acids)=362AA_BP=1
MRSLHQLKADDVLKPEWSRDGHQLRLEVPSAVTKVPHPKTTARRSCPQELKTMELSDSDRPVSFGSTSSSASSRDSHGSFGSRMTLVSNS
HMGLFNQDKEVGAIKLELIPARPFSSSELQRDNPATGQQNADEGSERPPRAQWRVDSNGAPKTIADSATSPKLLYVDRVVQEILETERTY
VQDLKSIVEDYLDCIRDQTKLPLGTEERSALFGNIQDIYHFNSELLQDLENCENDPVAIAECFVSKVPIVDKIRTIAQAVYGAKDIELSP
EAQAKIDRYTQQGFGNLPICMAKTHLSLSHQPDKKGVPRDFILPISDVRASIGAGFIYPLVGTMSTMPGLPTRPCFYDIDLDTETEQVKG

--------------------------------------------------------------
>66263_66263_6_PLEKHG1-MTHFD1L_PLEKHG1_chr6_151107595_ENST00000367328_MTHFD1L_chr6_151355629_ENST00000367321_length(transcript)=1638nt_BP=894nt
GAGGAAGAGGAAGTCGGAGCCCGAGCCTGAGCCCGAGCCCGAGCCCGACGGCGGCTGCAGGGCGCTCCGGCAGCCCGAGCCGGCGCAGCG
CAGCCCGCACCCTCCCCGCCCGACCTGCGAGCGCCGCCCGGGCATGCGAAGCCGTCCCTCCCCGGGTGAAGACTGATGAGAAGAGTCTGT
GGGTGAAGACATTGAAAAGGTTTCAACTATAAAAATGGGCACCAGTTGCGTCTTGAAGTGCCATCAGCTGTAACCAAAGTTCCACATCCC
AAGACGACAGCCAGGCGTTCCTGCCCTCAAGAACTGAAGACAATGGAGCTCTCTGATAGTGACCGACCCGTCAGCTTCGGTTCCACATCA
TCCTCGGCCTCTTCCCGCGACAGCCATGGTTCCTTCGGCAGCAGAATGACCTTAGTTTCAAATAGCCACATGGGCTTGTTTAACCAGGAT
AAGGAGGTAGGGGCCATAAAACTGGAGCTGATTCCTGCCAGGCCGTTTTCCAGCAGCGAGCTGCAGAGGGACAACCCCGCCACGGGGCAA
CAGAACGCGGATGAGGGCAGCGAAAGGCCACCCAGAGCGCAGTGGAGAGTGGACTCAAACGGGGCACCCAAGACGATCGCAGACTCGGCC
ACGAGCCCCAAGCTCCTCTATGTGGATAGAGTTGTTCAGGAAATTCTGGAAACCGAAAGGACTTATGTACAAGATTTAAAAAGCATCGTA
GAGGATTACCTTGACTGCATCAGGGACCAAACAAAACTTCCCCTGGGGACCGAAGAAAGATCAGCCCTTTTTGGAAACATACAGGATATC
TACCACTTCAATAGTGAACTTCTGCAAGATTTGGAAAACTGTGAAAATGATCCTGTGGCCATAGCAGAGTGTTTTGTGTCCAAGGTTCCA
ATTGTGGACAAGATAAGGACCATTGCTCAGGCTGTCTATGGAGCCAAAGATATTGAACTCTCTCCTGAGGCACAAGCCAAAATAGATCGT
TACACTCAACAGGGTTTTGGAAATTTGCCCATCTGCATGGCAAAGACCCACCTTTCTCTATCTCACCAACCTGACAAAAAAGGTGTGCCA
AGGGACTTCATCTTACCTATCAGTGACGTCCGGGCCAGCATAGGCGCTGGGTTCATTTACCCTTTGGTCGGAACGATGAGCACCATGCCA
GGACTGCCCACCCGGCCCTGCTTTTATGACATAGATCTTGATACCGAAACAGAACAAGTTAAAGGCTTGTTCTAAGTGGACAAGGCTCTC
ACAGGACCCGATGCAGACTCCTGAAACAGACTACTCTTTGCCTTTTTGCTGCAGTTGGAGAAGAAACTGAATTTGAAAAATGTCTGTTAT
GCAATGCTGGAGACATGGTGAAATAGGCCAAAGATTTCTTCTTCGTTCAAGATGAATTCTGTTCACAGTGGAGTATGGTGTTCGGCAAAA
GGACCTCCACCAAGACTGAAAGAAACTAATTTATTTCTGTTTCTGTGGAGTTTCCATTATTTCTACTGCTTACACTTTAGAATGTTTATT
TTATGGGGACTAAGGGATTAGGAGTGTGAACTAAAAGGTAACATTTTCCACTCTCAAGTTTTCTACTTTGTCTTTGAACTGAAAATAAAC

>66263_66263_6_PLEKHG1-MTHFD1L_PLEKHG1_chr6_151107595_ENST00000367328_MTHFD1L_chr6_151355629_ENST00000367321_length(amino acids)=339AA_BP=1
MRLEVPSAVTKVPHPKTTARRSCPQELKTMELSDSDRPVSFGSTSSSASSRDSHGSFGSRMTLVSNSHMGLFNQDKEVGAIKLELIPARP
FSSSELQRDNPATGQQNADEGSERPPRAQWRVDSNGAPKTIADSATSPKLLYVDRVVQEILETERTYVQDLKSIVEDYLDCIRDQTKLPL
GTEERSALFGNIQDIYHFNSELLQDLENCENDPVAIAECFVSKVPIVDKIRTIAQAVYGAKDIELSPEAQAKIDRYTQQGFGNLPICMAK

--------------------------------------------------------------
>66263_66263_7_PLEKHG1-MTHFD1L_PLEKHG1_chr6_151153341_ENST00000358517_MTHFD1L_chr6_151277131_ENST00000367321_length(transcript)=4909nt_BP=3305nt
AATATTTCTACGGAAGGCGCTGCACAGACTAGCAAAGGCTGTTTCTTTTACCTGACTGAGGTCACTGCATCAGCTGAAGGCAGACGATGT
GCTTAAGCCTGAGTGGAGCAGAGATGGGCACCAGTTGCGTCTTGAAGTGCCATCAGCTGTAACCAAAGTTCCACATCCCAAGACGACAGC
CAGGCGTTCCTGCCCTCAAGAACTGAAGACAATGGAGCTCTCTGATAGTGACCGACCCGTCAGCTTCGGTTCCACATCATCCTCGGCCTC
TTCCCGCGACAGCCATGGTTCCTTCGGCAGCAGAATGACCTTAGTTTCAAATAGCCACATGGGCTTGTTTAACCAGGATAAGGAGGTAGG
GGCCATAAAACTGGAGCTGATTCCTGCCAGGCCGTTTTCCAGCAGCGAGCTGCAGAGGGACAACCCCGCCACGGGGCAACAGAACGCGGA
TGAGGGCAGCGAAAGGCCACCCAGAGCGCAGTGGAGAGTGGACTCAAACGGGGCACCCAAGACGATCGCAGACTCGGCCACGAGCCCCAA
GCTCCTCTATGTGGATAGAGTTGTTCAGGAAATTCTGGAAACCGAAAGGACTTATGTACAAGATTTAAAAAGCATCGTAGAGGATTACCT
TGACTGCATCAGGGACCAAACAAAACTTCCCCTGGGGACCGAAGAAAGATCAGCCCTTTTTGGAAACATACAGGATATCTACCACTTCAA
TAGTGAACTTCTGCAAGATTTGGAAAACTGTGAAAATGATCCTGTGGCCATAGCAGAGTGTTTTGTGTCCAAGAGTGAAGAGTTCCACAT
TTATACCCAGTATTGCACTAACTATCCAAGGTCCGTGGCTGTGCTAACAGAGTGTATGAGGAACAAGATACTGGCCAAATTCTTCAGGGA
GCGTCAGGAAACTCTGAAACACTCGCTGCCTCTGGGGTCCTATCTCTTGAAACCAGTTCAGCGGATTCTCAAGTATCATCTCCTTCTGCA
TGAAATAGAAAACCACCTTGATAAGGACACAGAAGGCTATGATGTGGTGCTTGATGCTATAGACACAATGCAGCGAGTCGCCTGGCATAT
CAATGACATGAAGCGGAAACACGAGCACGCGGTCCGGTTACAGGAGATACAGAGTTTGCTCACTAACTGGAAGGGGCCAGACCTGACCAG
CTACGGGGAACTGGTGCTTGAGGGAACCTTCCGCATCCAGCGAGCCAAGAATGAGCGGACGCTCTTCCTCTTCGACAAGCTGCTGCTCAT
CACGAAGAAGAGAGATGACACGTTTACATACAAAGCTCACATCCTGTGTGGCAACCTCATGCTTGTGGAGGTGATTCCAAAAGAGCCGCT
CAGCTTCAGCGTCTTCCACTACAAGAATCCCAAGCTGCAGCACACAGTCCAGGCCAAATCCCAGCAAGACAAACGCCTCTGGGTTCTGCA
CCTAAAGAGACTGATTCTGGAGAACCATGCAGCCAAGATTCCAGCTAAGGCCAAGCAAGCAATCCTTGAAATGGATGCCATTCATCATCC
AGGCTTCTGTTACAGTCCTGAGGGAGGGACGAAAGCACTGTTCGGCTCTAAAGAAGGTTCTGCTCCATATCGGCTGAGAAGAAAATCTGA
ACCTTCCTCACGGTCACATAAAGTTTTGAAGACCAGTGAAACAGCACAAGACATCCAAAAGGTTTCTAGAGAGGAAGGATCTCCCCAGCT
GTCTTCAGCAAGGCCGTCTCCTGCCCAGAGAAATAGTCAGCCTAGCAGTTCTACCATGATCAGCGTGCTTCGAGCGGGTGGAGCTCTCAG
AAACATCTGGACCGATCACCAGATCAGGCAAGCCTTGTTTCCCAGCCGACGGTCCCCGCAGGAGAATGAGGATGATGAAGATGATTATCA
GATGTTCGTGCCGTCATTTTCCTCCTCAGATCTGAACTCTACCAGACTATGTGAAGATAGCACTTCTAGTCGCCCTTGCAGCTGGCATAT
GGGACAGATGGAGTCCACAGAGACCTCCAGCTCTGGTCACAGGATTGTCAGGCGGGCCAGCAGTGCTGGGGAGAGCAACACATGCCCTCC
TGAAATAGGAACTAGTGACAGAACTAGGGAACTGCAGAACAGCCCCAAAACAGAAGGGCAGGAGGAGATGACTCCCTTTGGGTCATCCAT
AGAGTTGACTATTGATGACATAGACCATGTCTATGATAACATCAGTTATGAGGACTTAAAACTAATGGTTGCTAAGCGGGAAGAAGCTGA
ATCCACTCCCTCTAAATCAGCCAGGGACTCCGTTCGCCCCAAGAGCACCCCAGAGTTAGCCTTCACAAAGAGGCAAGCTGGCCACAGTAA
GGGCTCTCTTTACGCACAAACAGATGGCACCCTCTCAGGTGGAGAGGCATCCAGCCAAAGCACGCATGAACTCCAAGCGGTTGAGGAGAA
CATCTATGACACCATAGGGCTCCCAGATCCTCCGTCGCTGGGTTTTAAGTGCAGCAGCCTAAAGCGTGCAAAGCGGAGCACCTTTTTGGG
TCTGGAGGCCGACTTCGTGTGCTGTGACAGCCTGAGGCCATTTGTTTCCCAAGACAGCCTCCAGCTCAGTGAGGACGAAGCCCCTTACCA
TCAGGCCACTCCCGATCATGGTTATCTGAGTTTGCTGTATGACTCTCCCAGTGGTAACTTGTCTATGCCTCATAAGCCTGTATCTGATAA
ACTGTCCGAAGAAGTAGATGAAATCTGGAATGACCTGGAAAATTACATCAAGAAAAATGAAGACAAGGCCAGAGACCGTCTCCTGGCAGC
GTTTCCTGTGAGCAAGGATGATGTGCCAGACAGGCTGCACGCAGAGAGCACCCCTGAGCTGAGCCGGGACGTGGGGCGCTCTGTGTCCAC
GCTGTCCCTGCCTGAGAGCCAGGCTCTCCTCACGCCCGTGAAGAGCAGGGCTGGCAGAGCCAGCCGCGCCAACTGCCCCTTTGAGGAAGA
CCTGATTTCTAAAGAAGGCTCCTTTATGAGCCTTAACCGGCTTTCTCTGGCTAGTGAAATGCCCCTCATGGACAATCCCTACGACCTGGC
CAACAGTGGCCTGTCTCAAACAGACCCAGAAAACCCTGACCTGGGGATGGAGGCCACAGATAAGACAAAAAGCAGGGTGTTTATGATGGC
TCGGCAGTACAGTCAGAAGATTAAGAAGGCGAATCAACTTTTAAAAGTGAAAAGTCTGGAGCTGGAGCAGCCGCCGGCCAGTCAGCATCA
GAAATCCATGCACAAAGACCTGGCTGCCATCTTGGAAGAGAAGAAGCAAGGAGGGCCCGCCATTGTATTGGATACAAATGACCGATTTCT
ACGAAAAATAACCATCGGGCAGGGAAACACAGAGAAGGGCCATTACCGGCAGGCGCAGTTTGACATCGCAGTGGCCAGCGAGATCATGGC
GGTGCTGGCCCTGACGGACAGCCTCGCAGACATGAAGGCACGGCTGGGAAGGATGGTGGTGGCCAGTGACAAAAGCGGGCAGCCTGTGAC
AGCAGATGATTTGGGGGTGACAGGTGCTTTGACAGTTTTGATGAAAGATGCAATAAAACCAAACCTGATGCAGACCCTGGAAGGGACACC
TGTGTTCGTGCATGCGGGCCCTTTTGCTAACATTGCTCACGGCAACTCTTCAGTGTTGGCTGATAAAATTGCCCTGAAACTGGTTGGTGA
AGAAGGATTTGTAGTGACCGAAGCTGGCTTTGGTGCTGACATCGGAATGGAGAAATTCTTCAACATCAAGTGCCGAGCTTCCGGCTTGGT
GCCCAACGTGGTTGTGTTAGTGGCAACGGTGCGAGCTCTGAAGATGCATGGAGGCGGGCCAAGTGTAACGGCTGGTGTTCCTCTTAAGAA
AGAATATACAGAGGAGAACATCCAGCTGGTGGCAGACGGCTGCTGTAACCTCCAGAAGCAAATTCAGATCACTCAGCTCTTTGGGGTTCC
CGTTGTGGTGGCTCTGAATGTCTTCAAGACCGACACCCGCGCTGAGATTGACTTGGTGTGTGAGCTTGCAAAGCGGGCTGGTGCCTTTGA
TGCAGTCCCCTGCTATCACTGGTCCGTTGGTGGAAAAGGATCGGTGGACTTGGCTCGGGCTGTGAGAGAGGCTGCGAGTAAAAGAAGCCG
ATTCCAGTTCCTGTATGATGTTCAGGTTCCAATTGTGGACAAGATAAGGACCATTGCTCAGGCTGTCTATGGAGCCAAAGATATTGAACT
CTCTCCTGAGGCACAAGCCAAAATAGATCGTTACACTCAACAGGGTTTTGGAAATTTGCCCATCTGCATGGCAAAGACCCACCTTTCTCT
ATCTCACCAACCTGACAAAAAAGGTGTGCCAAGGGACTTCATCTTACCTATCAGTGACGTCCGGGCCAGCATAGGCGCTGGGTTCATTTA
CCCTTTGGTCGGAACGATGAGCACCATGCCAGGACTGCCCACCCGGCCCTGCTTTTATGACATAGATCTTGATACCGAAACAGAACAAGT
TAAAGGCTTGTTCTAAGTGGACAAGGCTCTCACAGGACCCGATGCAGACTCCTGAAACAGACTACTCTTTGCCTTTTTGCTGCAGTTGGA
GAAGAAACTGAATTTGAAAAATGTCTGTTATGCAATGCTGGAGACATGGTGAAATAGGCCAAAGATTTCTTCTTCGTTCAAGATGAATTC
TGTTCACAGTGGAGTATGGTGTTCGGCAAAAGGACCTCCACCAAGACTGAAAGAAACTAATTTATTTCTGTTTCTGTGGAGTTTCCATTA
TTTCTACTGCTTACACTTTAGAATGTTTATTTTATGGGGACTAAGGGATTAGGAGTGTGAACTAAAAGGTAACATTTTCCACTCTCAAGT

>66263_66263_7_PLEKHG1-MTHFD1L_PLEKHG1_chr6_151153341_ENST00000358517_MTHFD1L_chr6_151277131_ENST00000367321_length(amino acids)=1486AA_BP=1
MRSLHQLKADDVLKPEWSRDGHQLRLEVPSAVTKVPHPKTTARRSCPQELKTMELSDSDRPVSFGSTSSSASSRDSHGSFGSRMTLVSNS
HMGLFNQDKEVGAIKLELIPARPFSSSELQRDNPATGQQNADEGSERPPRAQWRVDSNGAPKTIADSATSPKLLYVDRVVQEILETERTY
VQDLKSIVEDYLDCIRDQTKLPLGTEERSALFGNIQDIYHFNSELLQDLENCENDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTEC
MRNKILAKFFRERQETLKHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWHINDMKRKHEHAVRLQEIQS
LLTNWKGPDLTSYGELVLEGTFRIQRAKNERTLFLFDKLLLITKKRDDTFTYKAHILCGNLMLVEVIPKEPLSFSVFHYKNPKLQHTVQA
KSQQDKRLWVLHLKRLILENHAAKIPAKAKQAILEMDAIHHPGFCYSPEGGTKALFGSKEGSAPYRLRRKSEPSSRSHKVLKTSETAQDI
QKVSREEGSPQLSSARPSPAQRNSQPSSSTMISVLRAGGALRNIWTDHQIRQALFPSRRSPQENEDDEDDYQMFVPSFSSSDLNSTRLCE
DSTSSRPCSWHMGQMESTETSSSGHRIVRRASSAGESNTCPPEIGTSDRTRELQNSPKTEGQEEMTPFGSSIELTIDDIDHVYDNISYED
LKLMVAKREEAESTPSKSARDSVRPKSTPELAFTKRQAGHSKGSLYAQTDGTLSGGEASSQSTHELQAVEENIYDTIGLPDPPSLGFKCS
SLKRAKRSTFLGLEADFVCCDSLRPFVSQDSLQLSEDEAPYHQATPDHGYLSLLYDSPSGNLSMPHKPVSDKLSEEVDEIWNDLENYIKK
NEDKARDRLLAAFPVSKDDVPDRLHAESTPELSRDVGRSVSTLSLPESQALLTPVKSRAGRASRANCPFEEDLISKEGSFMSLNRLSLAS
EMPLMDNPYDLANSGLSQTDPENPDLGMEATDKTKSRVFMMARQYSQKIKKANQLLKVKSLELEQPPASQHQKSMHKDLAAILEEKKQGG
PAIVLDTNDRFLRKITIGQGNTEKGHYRQAQFDIAVASEIMAVLALTDSLADMKARLGRMVVASDKSGQPVTADDLGVTGALTVLMKDAI
KPNLMQTLEGTPVFVHAGPFANIAHGNSSVLADKIALKLVGEEGFVVTEAGFGADIGMEKFFNIKCRASGLVPNVVVLVATVRALKMHGG
GPSVTAGVPLKKEYTEENIQLVADGCCNLQKQIQITQLFGVPVVVALNVFKTDTRAEIDLVCELAKRAGAFDAVPCYHWSVGGKGSVDLA
RAVREAASKRSRFQFLYDVQVPIVDKIRTIAQAVYGAKDIELSPEAQAKIDRYTQQGFGNLPICMAKTHLSLSHQPDKKGVPRDFILPIS

--------------------------------------------------------------
>66263_66263_8_PLEKHG1-MTHFD1L_PLEKHG1_chr6_151153341_ENST00000367328_MTHFD1L_chr6_151277131_ENST00000367321_length(transcript)=5010nt_BP=3406nt
GAGGAAGAGGAAGTCGGAGCCCGAGCCTGAGCCCGAGCCCGAGCCCGACGGCGGCTGCAGGGCGCTCCGGCAGCCCGAGCCGGCGCAGCG
CAGCCCGCACCCTCCCCGCCCGACCTGCGAGCGCCGCCCGGGCATGCGAAGCCGTCCCTCCCCGGGTGAAGACTGATGAGAAGAGTCTGT
GGGTGAAGACATTGAAAAGGTTTCAACTATAAAAATGGGCACCAGTTGCGTCTTGAAGTGCCATCAGCTGTAACCAAAGTTCCACATCCC
AAGACGACAGCCAGGCGTTCCTGCCCTCAAGAACTGAAGACAATGGAGCTCTCTGATAGTGACCGACCCGTCAGCTTCGGTTCCACATCA
TCCTCGGCCTCTTCCCGCGACAGCCATGGTTCCTTCGGCAGCAGAATGACCTTAGTTTCAAATAGCCACATGGGCTTGTTTAACCAGGAT
AAGGAGGTAGGGGCCATAAAACTGGAGCTGATTCCTGCCAGGCCGTTTTCCAGCAGCGAGCTGCAGAGGGACAACCCCGCCACGGGGCAA
CAGAACGCGGATGAGGGCAGCGAAAGGCCACCCAGAGCGCAGTGGAGAGTGGACTCAAACGGGGCACCCAAGACGATCGCAGACTCGGCC
ACGAGCCCCAAGCTCCTCTATGTGGATAGAGTTGTTCAGGAAATTCTGGAAACCGAAAGGACTTATGTACAAGATTTAAAAAGCATCGTA
GAGGATTACCTTGACTGCATCAGGGACCAAACAAAACTTCCCCTGGGGACCGAAGAAAGATCAGCCCTTTTTGGAAACATACAGGATATC
TACCACTTCAATAGTGAACTTCTGCAAGATTTGGAAAACTGTGAAAATGATCCTGTGGCCATAGCAGAGTGTTTTGTGTCCAAGAGTGAA
GAGTTCCACATTTATACCCAGTATTGCACTAACTATCCAAGGTCCGTGGCTGTGCTAACAGAGTGTATGAGGAACAAGATACTGGCCAAA
TTCTTCAGGGAGCGTCAGGAAACTCTGAAACACTCGCTGCCTCTGGGGTCCTATCTCTTGAAACCAGTTCAGCGGATTCTCAAGTATCAT
CTCCTTCTGCATGAAATAGAAAACCACCTTGATAAGGACACAGAAGGCTATGATGTGGTGCTTGATGCTATAGACACAATGCAGCGAGTC
GCCTGGCATATCAATGACATGAAGCGGAAACACGAGCACGCGGTCCGGTTACAGGAGATACAGAGTTTGCTCACTAACTGGAAGGGGCCA
GACCTGACCAGCTACGGGGAACTGGTGCTTGAGGGAACCTTCCGCATCCAGCGAGCCAAGAATGAGCGGACGCTCTTCCTCTTCGACAAG
CTGCTGCTCATCACGAAGAAGAGAGATGACACGTTTACATACAAAGCTCACATCCTGTGTGGCAACCTCATGCTTGTGGAGGTGATTCCA
AAAGAGCCGCTCAGCTTCAGCGTCTTCCACTACAAGAATCCCAAGCTGCAGCACACAGTCCAGGCCAAATCCCAGCAAGACAAACGCCTC
TGGGTTCTGCACCTAAAGAGACTGATTCTGGAGAACCATGCAGCCAAGATTCCAGCTAAGGCCAAGCAAGCAATCCTTGAAATGGATGCC
ATTCATCATCCAGGCTTCTGTTACAGTCCTGAGGGAGGGACGAAAGCACTGTTCGGCTCTAAAGAAGGTTCTGCTCCATATCGGCTGAGA
AGAAAATCTGAACCTTCCTCACGGTCACATAAAGTTTTGAAGACCAGTGAAACAGCACAAGACATCCAAAAGGTTTCTAGAGAGGAAGGA
TCTCCCCAGCTGTCTTCAGCAAGGCCGTCTCCTGCCCAGAGAAATAGTCAGCCTAGCAGTTCTACCATGATCAGCGTGCTTCGAGCGGGT
GGAGCTCTCAGAAACATCTGGACCGATCACCAGATCAGGCAAGCCTTGTTTCCCAGCCGACGGTCCCCGCAGGAGAATGAGGATGATGAA
GATGATTATCAGATGTTCGTGCCGTCATTTTCCTCCTCAGATCTGAACTCTACCAGACTATGTGAAGATAGCACTTCTAGTCGCCCTTGC
AGCTGGCATATGGGACAGATGGAGTCCACAGAGACCTCCAGCTCTGGTCACAGGATTGTCAGGCGGGCCAGCAGTGCTGGGGAGAGCAAC
ACATGCCCTCCTGAAATAGGAACTAGTGACAGAACTAGGGAACTGCAGAACAGCCCCAAAACAGAAGGGCAGGAGGAGATGACTCCCTTT
GGGTCATCCATAGAGTTGACTATTGATGACATAGACCATGTCTATGATAACATCAGTTATGAGGACTTAAAACTAATGGTTGCTAAGCGG
GAAGAAGCTGAATCCACTCCCTCTAAATCAGCCAGGGACTCCGTTCGCCCCAAGAGCACCCCAGAGTTAGCCTTCACAAAGAGGCAAGCT
GGCCACAGTAAGGGCTCTCTTTACGCACAAACAGATGGCACCCTCTCAGGTGGAGAGGCATCCAGCCAAAGCACGCATGAACTCCAAGCG
GTTGAGGAGAACATCTATGACACCATAGGGCTCCCAGATCCTCCGTCGCTGGGTTTTAAGTGCAGCAGCCTAAAGCGTGCAAAGCGGAGC
ACCTTTTTGGGTCTGGAGGCCGACTTCGTGTGCTGTGACAGCCTGAGGCCATTTGTTTCCCAAGACAGCCTCCAGCTCAGTGAGGACGAA
GCCCCTTACCATCAGGCCACTCCCGATCATGGTTATCTGAGTTTGCTGTATGACTCTCCCAGTGGTAACTTGTCTATGCCTCATAAGCCT
GTATCTGATAAACTGTCCGAAGAAGTAGATGAAATCTGGAATGACCTGGAAAATTACATCAAGAAAAATGAAGACAAGGCCAGAGACCGT
CTCCTGGCAGCGTTTCCTGTGAGCAAGGATGATGTGCCAGACAGGCTGCACGCAGAGAGCACCCCTGAGCTGAGCCGGGACGTGGGGCGC
TCTGTGTCCACGCTGTCCCTGCCTGAGAGCCAGGCTCTCCTCACGCCCGTGAAGAGCAGGGCTGGCAGAGCCAGCCGCGCCAACTGCCCC
TTTGAGGAAGACCTGATTTCTAAAGAAGGCTCCTTTATGAGCCTTAACCGGCTTTCTCTGGCTAGTGAAATGCCCCTCATGGACAATCCC
TACGACCTGGCCAACAGTGGCCTGTCTCAAACAGACCCAGAAAACCCTGACCTGGGGATGGAGGCCACAGATAAGACAAAAAGCAGGGTG
TTTATGATGGCTCGGCAGTACAGTCAGAAGATTAAGAAGGCGAATCAACTTTTAAAAGTGAAAAGTCTGGAGCTGGAGCAGCCGCCGGCC
AGTCAGCATCAGAAATCCATGCACAAAGACCTGGCTGCCATCTTGGAAGAGAAGAAGCAAGGAGGGCCCGCCATTGTATTGGATACAAAT
GACCGATTTCTACGAAAAATAACCATCGGGCAGGGAAACACAGAGAAGGGCCATTACCGGCAGGCGCAGTTTGACATCGCAGTGGCCAGC
GAGATCATGGCGGTGCTGGCCCTGACGGACAGCCTCGCAGACATGAAGGCACGGCTGGGAAGGATGGTGGTGGCCAGTGACAAAAGCGGG
CAGCCTGTGACAGCAGATGATTTGGGGGTGACAGGTGCTTTGACAGTTTTGATGAAAGATGCAATAAAACCAAACCTGATGCAGACCCTG
GAAGGGACACCTGTGTTCGTGCATGCGGGCCCTTTTGCTAACATTGCTCACGGCAACTCTTCAGTGTTGGCTGATAAAATTGCCCTGAAA
CTGGTTGGTGAAGAAGGATTTGTAGTGACCGAAGCTGGCTTTGGTGCTGACATCGGAATGGAGAAATTCTTCAACATCAAGTGCCGAGCT
TCCGGCTTGGTGCCCAACGTGGTTGTGTTAGTGGCAACGGTGCGAGCTCTGAAGATGCATGGAGGCGGGCCAAGTGTAACGGCTGGTGTT
CCTCTTAAGAAAGAATATACAGAGGAGAACATCCAGCTGGTGGCAGACGGCTGCTGTAACCTCCAGAAGCAAATTCAGATCACTCAGCTC
TTTGGGGTTCCCGTTGTGGTGGCTCTGAATGTCTTCAAGACCGACACCCGCGCTGAGATTGACTTGGTGTGTGAGCTTGCAAAGCGGGCT
GGTGCCTTTGATGCAGTCCCCTGCTATCACTGGTCCGTTGGTGGAAAAGGATCGGTGGACTTGGCTCGGGCTGTGAGAGAGGCTGCGAGT
AAAAGAAGCCGATTCCAGTTCCTGTATGATGTTCAGGTTCCAATTGTGGACAAGATAAGGACCATTGCTCAGGCTGTCTATGGAGCCAAA
GATATTGAACTCTCTCCTGAGGCACAAGCCAAAATAGATCGTTACACTCAACAGGGTTTTGGAAATTTGCCCATCTGCATGGCAAAGACC
CACCTTTCTCTATCTCACCAACCTGACAAAAAAGGTGTGCCAAGGGACTTCATCTTACCTATCAGTGACGTCCGGGCCAGCATAGGCGCT
GGGTTCATTTACCCTTTGGTCGGAACGATGAGCACCATGCCAGGACTGCCCACCCGGCCCTGCTTTTATGACATAGATCTTGATACCGAA
ACAGAACAAGTTAAAGGCTTGTTCTAAGTGGACAAGGCTCTCACAGGACCCGATGCAGACTCCTGAAACAGACTACTCTTTGCCTTTTTG
CTGCAGTTGGAGAAGAAACTGAATTTGAAAAATGTCTGTTATGCAATGCTGGAGACATGGTGAAATAGGCCAAAGATTTCTTCTTCGTTC
AAGATGAATTCTGTTCACAGTGGAGTATGGTGTTCGGCAAAAGGACCTCCACCAAGACTGAAAGAAACTAATTTATTTCTGTTTCTGTGG
AGTTTCCATTATTTCTACTGCTTACACTTTAGAATGTTTATTTTATGGGGACTAAGGGATTAGGAGTGTGAACTAAAAGGTAACATTTTC

>66263_66263_8_PLEKHG1-MTHFD1L_PLEKHG1_chr6_151153341_ENST00000367328_MTHFD1L_chr6_151277131_ENST00000367321_length(amino acids)=1463AA_BP=1
MRLEVPSAVTKVPHPKTTARRSCPQELKTMELSDSDRPVSFGSTSSSASSRDSHGSFGSRMTLVSNSHMGLFNQDKEVGAIKLELIPARP
FSSSELQRDNPATGQQNADEGSERPPRAQWRVDSNGAPKTIADSATSPKLLYVDRVVQEILETERTYVQDLKSIVEDYLDCIRDQTKLPL
GTEERSALFGNIQDIYHFNSELLQDLENCENDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKILAKFFRERQETLKHSLPL
GSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWHINDMKRKHEHAVRLQEIQSLLTNWKGPDLTSYGELVLEGTFR
IQRAKNERTLFLFDKLLLITKKRDDTFTYKAHILCGNLMLVEVIPKEPLSFSVFHYKNPKLQHTVQAKSQQDKRLWVLHLKRLILENHAA
KIPAKAKQAILEMDAIHHPGFCYSPEGGTKALFGSKEGSAPYRLRRKSEPSSRSHKVLKTSETAQDIQKVSREEGSPQLSSARPSPAQRN
SQPSSSTMISVLRAGGALRNIWTDHQIRQALFPSRRSPQENEDDEDDYQMFVPSFSSSDLNSTRLCEDSTSSRPCSWHMGQMESTETSSS
GHRIVRRASSAGESNTCPPEIGTSDRTRELQNSPKTEGQEEMTPFGSSIELTIDDIDHVYDNISYEDLKLMVAKREEAESTPSKSARDSV
RPKSTPELAFTKRQAGHSKGSLYAQTDGTLSGGEASSQSTHELQAVEENIYDTIGLPDPPSLGFKCSSLKRAKRSTFLGLEADFVCCDSL
RPFVSQDSLQLSEDEAPYHQATPDHGYLSLLYDSPSGNLSMPHKPVSDKLSEEVDEIWNDLENYIKKNEDKARDRLLAAFPVSKDDVPDR
LHAESTPELSRDVGRSVSTLSLPESQALLTPVKSRAGRASRANCPFEEDLISKEGSFMSLNRLSLASEMPLMDNPYDLANSGLSQTDPEN
PDLGMEATDKTKSRVFMMARQYSQKIKKANQLLKVKSLELEQPPASQHQKSMHKDLAAILEEKKQGGPAIVLDTNDRFLRKITIGQGNTE
KGHYRQAQFDIAVASEIMAVLALTDSLADMKARLGRMVVASDKSGQPVTADDLGVTGALTVLMKDAIKPNLMQTLEGTPVFVHAGPFANI
AHGNSSVLADKIALKLVGEEGFVVTEAGFGADIGMEKFFNIKCRASGLVPNVVVLVATVRALKMHGGGPSVTAGVPLKKEYTEENIQLVA
DGCCNLQKQIQITQLFGVPVVVALNVFKTDTRAEIDLVCELAKRAGAFDAVPCYHWSVGGKGSVDLARAVREAASKRSRFQFLYDVQVPI
VDKIRTIAQAVYGAKDIELSPEAQAKIDRYTQQGFGNLPICMAKTHLSLSHQPDKKGVPRDFILPISDVRASIGAGFIYPLVGTMSTMPG

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Fusion Gene PPI Analysis for PLEKHG1-MTHFD1L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PLEKHG1-MTHFD1L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PLEKHG1-MTHFD1L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource