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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:PLEKHG5-SAMD4B (FusionGDB2 ID:66278)

Fusion Gene Summary for PLEKHG5-SAMD4B

Fusion gene summary

Fusion gene information	Fusion gene name: PLEKHG5-SAMD4B
	Fusion gene ID: 66278
		Hgene	Tgene
	Gene symbol	PLEKHG5	SAMD4B
	Gene ID	57449	55095
	Gene name	pleckstrin homology and RhoGEF domain containing G5	sterile alpha motif domain containing 4B
	Synonyms	CMTRIC\|DSMA4\|GEF720\|Syx\|Tech	SMGB\|Smaug2
	Cytomap	1p36.31	19q13.2
	Type of gene	protein-coding	protein-coding
	Description	pleckstrin homology domain-containing family G member 5NFkB activating proteinPH domain-containing family G member 5guanine nucleotide exchange factor 720novel PH domain-containing proteinpleckstrin homology domain containing, family G (with RhoGef d	protein Smaug homolog 2SAM domain-containing protein 4Bsmaug 2smaug homolog Bsterile alpha motif domain-containing protein 4B
	Modification date	20200320	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000377732, ENST00000377740, ENST00000377748, ENST00000400915, ENST00000537245, ENST00000340850, ENST00000377725, ENST00000377737, ENST00000544978, ENST00000377728, ENST00000400913, ENST00000535355,	ENST00000594204, ENST00000596368, ENST00000314471, ENST00000598913,
Fusion gene scores	* DoF score	4 X 4 X 4=64	7 X 8 X 5=280
	# samples	5	8
	** MAII score	log2(5/64*10)=-0.356143810225275 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/280*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: PLEKHG5 [Title/Abstract] AND SAMD4B [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	PLEKHG5(6550505)-SAMD4B(39870606), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across PLEKHG5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SAMD4B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-VQ-A8PE-01A	PLEKHG5	chr1	6550505	-	SAMD4B	chr19	39870606	+
ChimerDB4	STAD	TCGA-VQ-A8PE-01A	PLEKHG5	chr1	6556553	-	SAMD4B	chr19	39870606	+

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Fusion Gene ORF analysis for PLEKHG5-SAMD4B

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000377732	ENST00000594204	PLEKHG5	chr1	6556553	-	SAMD4B	chr19	39870606	+
5CDS-intron	ENST00000377732	ENST00000596368	PLEKHG5	chr1	6556553	-	SAMD4B	chr19	39870606	+
5CDS-intron	ENST00000377740	ENST00000594204	PLEKHG5	chr1	6556553	-	SAMD4B	chr19	39870606	+
5CDS-intron	ENST00000377740	ENST00000596368	PLEKHG5	chr1	6556553	-	SAMD4B	chr19	39870606	+
5CDS-intron	ENST00000377748	ENST00000594204	PLEKHG5	chr1	6556553	-	SAMD4B	chr19	39870606	+
5CDS-intron	ENST00000377748	ENST00000596368	PLEKHG5	chr1	6556553	-	SAMD4B	chr19	39870606	+
5CDS-intron	ENST00000400915	ENST00000594204	PLEKHG5	chr1	6556553	-	SAMD4B	chr19	39870606	+
5CDS-intron	ENST00000400915	ENST00000596368	PLEKHG5	chr1	6556553	-	SAMD4B	chr19	39870606	+
5CDS-intron	ENST00000537245	ENST00000594204	PLEKHG5	chr1	6556553	-	SAMD4B	chr19	39870606	+
5CDS-intron	ENST00000537245	ENST00000596368	PLEKHG5	chr1	6556553	-	SAMD4B	chr19	39870606	+
5UTR-3CDS	ENST00000340850	ENST00000314471	PLEKHG5	chr1	6550505	-	SAMD4B	chr19	39870606	+
5UTR-3CDS	ENST00000340850	ENST00000598913	PLEKHG5	chr1	6550505	-	SAMD4B	chr19	39870606	+
5UTR-3CDS	ENST00000377725	ENST00000314471	PLEKHG5	chr1	6550505	-	SAMD4B	chr19	39870606	+
5UTR-3CDS	ENST00000377725	ENST00000598913	PLEKHG5	chr1	6550505	-	SAMD4B	chr19	39870606	+
5UTR-3CDS	ENST00000377737	ENST00000314471	PLEKHG5	chr1	6556553	-	SAMD4B	chr19	39870606	+
5UTR-3CDS	ENST00000377737	ENST00000598913	PLEKHG5	chr1	6556553	-	SAMD4B	chr19	39870606	+
5UTR-3CDS	ENST00000544978	ENST00000314471	PLEKHG5	chr1	6556553	-	SAMD4B	chr19	39870606	+
5UTR-3CDS	ENST00000544978	ENST00000598913	PLEKHG5	chr1	6556553	-	SAMD4B	chr19	39870606	+
5UTR-intron	ENST00000340850	ENST00000594204	PLEKHG5	chr1	6550505	-	SAMD4B	chr19	39870606	+
5UTR-intron	ENST00000340850	ENST00000596368	PLEKHG5	chr1	6550505	-	SAMD4B	chr19	39870606	+
5UTR-intron	ENST00000377725	ENST00000594204	PLEKHG5	chr1	6550505	-	SAMD4B	chr19	39870606	+
5UTR-intron	ENST00000377725	ENST00000596368	PLEKHG5	chr1	6550505	-	SAMD4B	chr19	39870606	+
5UTR-intron	ENST00000377737	ENST00000594204	PLEKHG5	chr1	6556553	-	SAMD4B	chr19	39870606	+
5UTR-intron	ENST00000377737	ENST00000596368	PLEKHG5	chr1	6556553	-	SAMD4B	chr19	39870606	+
5UTR-intron	ENST00000544978	ENST00000594204	PLEKHG5	chr1	6556553	-	SAMD4B	chr19	39870606	+
5UTR-intron	ENST00000544978	ENST00000596368	PLEKHG5	chr1	6556553	-	SAMD4B	chr19	39870606	+
In-frame	ENST00000377732	ENST00000314471	PLEKHG5	chr1	6556553	-	SAMD4B	chr19	39870606	+
In-frame	ENST00000377732	ENST00000598913	PLEKHG5	chr1	6556553	-	SAMD4B	chr19	39870606	+
In-frame	ENST00000377740	ENST00000314471	PLEKHG5	chr1	6556553	-	SAMD4B	chr19	39870606	+
In-frame	ENST00000377740	ENST00000598913	PLEKHG5	chr1	6556553	-	SAMD4B	chr19	39870606	+
In-frame	ENST00000377748	ENST00000314471	PLEKHG5	chr1	6556553	-	SAMD4B	chr19	39870606	+
In-frame	ENST00000377748	ENST00000598913	PLEKHG5	chr1	6556553	-	SAMD4B	chr19	39870606	+
In-frame	ENST00000400915	ENST00000314471	PLEKHG5	chr1	6556553	-	SAMD4B	chr19	39870606	+
In-frame	ENST00000400915	ENST00000598913	PLEKHG5	chr1	6556553	-	SAMD4B	chr19	39870606	+
In-frame	ENST00000537245	ENST00000314471	PLEKHG5	chr1	6556553	-	SAMD4B	chr19	39870606	+
In-frame	ENST00000537245	ENST00000598913	PLEKHG5	chr1	6556553	-	SAMD4B	chr19	39870606	+
intron-3CDS	ENST00000340850	ENST00000314471	PLEKHG5	chr1	6556553	-	SAMD4B	chr19	39870606	+
intron-3CDS	ENST00000340850	ENST00000598913	PLEKHG5	chr1	6556553	-	SAMD4B	chr19	39870606	+
intron-3CDS	ENST00000377725	ENST00000314471	PLEKHG5	chr1	6556553	-	SAMD4B	chr19	39870606	+
intron-3CDS	ENST00000377725	ENST00000598913	PLEKHG5	chr1	6556553	-	SAMD4B	chr19	39870606	+
intron-3CDS	ENST00000377728	ENST00000314471	PLEKHG5	chr1	6550505	-	SAMD4B	chr19	39870606	+
intron-3CDS	ENST00000377728	ENST00000314471	PLEKHG5	chr1	6556553	-	SAMD4B	chr19	39870606	+
intron-3CDS	ENST00000377728	ENST00000598913	PLEKHG5	chr1	6550505	-	SAMD4B	chr19	39870606	+
intron-3CDS	ENST00000377728	ENST00000598913	PLEKHG5	chr1	6556553	-	SAMD4B	chr19	39870606	+
intron-3CDS	ENST00000377732	ENST00000314471	PLEKHG5	chr1	6550505	-	SAMD4B	chr19	39870606	+
intron-3CDS	ENST00000377732	ENST00000598913	PLEKHG5	chr1	6550505	-	SAMD4B	chr19	39870606	+
intron-3CDS	ENST00000377737	ENST00000314471	PLEKHG5	chr1	6550505	-	SAMD4B	chr19	39870606	+
intron-3CDS	ENST00000377737	ENST00000598913	PLEKHG5	chr1	6550505	-	SAMD4B	chr19	39870606	+
intron-3CDS	ENST00000377740	ENST00000314471	PLEKHG5	chr1	6550505	-	SAMD4B	chr19	39870606	+
intron-3CDS	ENST00000377740	ENST00000598913	PLEKHG5	chr1	6550505	-	SAMD4B	chr19	39870606	+
intron-3CDS	ENST00000377748	ENST00000314471	PLEKHG5	chr1	6550505	-	SAMD4B	chr19	39870606	+
intron-3CDS	ENST00000377748	ENST00000598913	PLEKHG5	chr1	6550505	-	SAMD4B	chr19	39870606	+
intron-3CDS	ENST00000400913	ENST00000314471	PLEKHG5	chr1	6550505	-	SAMD4B	chr19	39870606	+
intron-3CDS	ENST00000400913	ENST00000314471	PLEKHG5	chr1	6556553	-	SAMD4B	chr19	39870606	+
intron-3CDS	ENST00000400913	ENST00000598913	PLEKHG5	chr1	6550505	-	SAMD4B	chr19	39870606	+
intron-3CDS	ENST00000400913	ENST00000598913	PLEKHG5	chr1	6556553	-	SAMD4B	chr19	39870606	+
intron-3CDS	ENST00000400915	ENST00000314471	PLEKHG5	chr1	6550505	-	SAMD4B	chr19	39870606	+
intron-3CDS	ENST00000400915	ENST00000598913	PLEKHG5	chr1	6550505	-	SAMD4B	chr19	39870606	+
intron-3CDS	ENST00000535355	ENST00000314471	PLEKHG5	chr1	6550505	-	SAMD4B	chr19	39870606	+
intron-3CDS	ENST00000535355	ENST00000314471	PLEKHG5	chr1	6556553	-	SAMD4B	chr19	39870606	+
intron-3CDS	ENST00000535355	ENST00000598913	PLEKHG5	chr1	6550505	-	SAMD4B	chr19	39870606	+
intron-3CDS	ENST00000535355	ENST00000598913	PLEKHG5	chr1	6556553	-	SAMD4B	chr19	39870606	+
intron-3CDS	ENST00000537245	ENST00000314471	PLEKHG5	chr1	6550505	-	SAMD4B	chr19	39870606	+
intron-3CDS	ENST00000537245	ENST00000598913	PLEKHG5	chr1	6550505	-	SAMD4B	chr19	39870606	+
intron-3CDS	ENST00000544978	ENST00000314471	PLEKHG5	chr1	6550505	-	SAMD4B	chr19	39870606	+
intron-3CDS	ENST00000544978	ENST00000598913	PLEKHG5	chr1	6550505	-	SAMD4B	chr19	39870606	+
intron-intron	ENST00000340850	ENST00000594204	PLEKHG5	chr1	6556553	-	SAMD4B	chr19	39870606	+
intron-intron	ENST00000340850	ENST00000596368	PLEKHG5	chr1	6556553	-	SAMD4B	chr19	39870606	+
intron-intron	ENST00000377725	ENST00000594204	PLEKHG5	chr1	6556553	-	SAMD4B	chr19	39870606	+
intron-intron	ENST00000377725	ENST00000596368	PLEKHG5	chr1	6556553	-	SAMD4B	chr19	39870606	+
intron-intron	ENST00000377728	ENST00000594204	PLEKHG5	chr1	6550505	-	SAMD4B	chr19	39870606	+
intron-intron	ENST00000377728	ENST00000594204	PLEKHG5	chr1	6556553	-	SAMD4B	chr19	39870606	+
intron-intron	ENST00000377728	ENST00000596368	PLEKHG5	chr1	6550505	-	SAMD4B	chr19	39870606	+
intron-intron	ENST00000377728	ENST00000596368	PLEKHG5	chr1	6556553	-	SAMD4B	chr19	39870606	+
intron-intron	ENST00000377732	ENST00000594204	PLEKHG5	chr1	6550505	-	SAMD4B	chr19	39870606	+
intron-intron	ENST00000377732	ENST00000596368	PLEKHG5	chr1	6550505	-	SAMD4B	chr19	39870606	+
intron-intron	ENST00000377737	ENST00000594204	PLEKHG5	chr1	6550505	-	SAMD4B	chr19	39870606	+
intron-intron	ENST00000377737	ENST00000596368	PLEKHG5	chr1	6550505	-	SAMD4B	chr19	39870606	+
intron-intron	ENST00000377740	ENST00000594204	PLEKHG5	chr1	6550505	-	SAMD4B	chr19	39870606	+
intron-intron	ENST00000377740	ENST00000596368	PLEKHG5	chr1	6550505	-	SAMD4B	chr19	39870606	+
intron-intron	ENST00000377748	ENST00000594204	PLEKHG5	chr1	6550505	-	SAMD4B	chr19	39870606	+
intron-intron	ENST00000377748	ENST00000596368	PLEKHG5	chr1	6550505	-	SAMD4B	chr19	39870606	+
intron-intron	ENST00000400913	ENST00000594204	PLEKHG5	chr1	6550505	-	SAMD4B	chr19	39870606	+
intron-intron	ENST00000400913	ENST00000594204	PLEKHG5	chr1	6556553	-	SAMD4B	chr19	39870606	+
intron-intron	ENST00000400913	ENST00000596368	PLEKHG5	chr1	6550505	-	SAMD4B	chr19	39870606	+
intron-intron	ENST00000400913	ENST00000596368	PLEKHG5	chr1	6556553	-	SAMD4B	chr19	39870606	+
intron-intron	ENST00000400915	ENST00000594204	PLEKHG5	chr1	6550505	-	SAMD4B	chr19	39870606	+
intron-intron	ENST00000400915	ENST00000596368	PLEKHG5	chr1	6550505	-	SAMD4B	chr19	39870606	+
intron-intron	ENST00000535355	ENST00000594204	PLEKHG5	chr1	6550505	-	SAMD4B	chr19	39870606	+
intron-intron	ENST00000535355	ENST00000594204	PLEKHG5	chr1	6556553	-	SAMD4B	chr19	39870606	+
intron-intron	ENST00000535355	ENST00000596368	PLEKHG5	chr1	6550505	-	SAMD4B	chr19	39870606	+
intron-intron	ENST00000535355	ENST00000596368	PLEKHG5	chr1	6556553	-	SAMD4B	chr19	39870606	+
intron-intron	ENST00000537245	ENST00000594204	PLEKHG5	chr1	6550505	-	SAMD4B	chr19	39870606	+
intron-intron	ENST00000537245	ENST00000596368	PLEKHG5	chr1	6550505	-	SAMD4B	chr19	39870606	+
intron-intron	ENST00000544978	ENST00000594204	PLEKHG5	chr1	6550505	-	SAMD4B	chr19	39870606	+
intron-intron	ENST00000544978	ENST00000596368	PLEKHG5	chr1	6550505	-	SAMD4B	chr19	39870606	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000377748	PLEKHG5	chr1	6556553	-	ENST00000598913	SAMD4B	chr19	39870606	+	1649	642	438	1190	250
ENST00000377748	PLEKHG5	chr1	6556553	-	ENST00000314471	SAMD4B	chr19	39870606	+	2596	642	438	1196	252
ENST00000377732	PLEKHG5	chr1	6556553	-	ENST00000598913	SAMD4B	chr19	39870606	+	1211	204	15	752	245
ENST00000377732	PLEKHG5	chr1	6556553	-	ENST00000314471	SAMD4B	chr19	39870606	+	2158	204	15	758	247
ENST00000400915	PLEKHG5	chr1	6556553	-	ENST00000598913	SAMD4B	chr19	39870606	+	1155	148	67	696	209
ENST00000400915	PLEKHG5	chr1	6556553	-	ENST00000314471	SAMD4B	chr19	39870606	+	2102	148	67	702	211
ENST00000377740	PLEKHG5	chr1	6556553	-	ENST00000598913	SAMD4B	chr19	39870606	+	1701	694	490	1242	250
ENST00000377740	PLEKHG5	chr1	6556553	-	ENST00000314471	SAMD4B	chr19	39870606	+	2648	694	490	1248	252
ENST00000537245	PLEKHG5	chr1	6556553	-	ENST00000598913	SAMD4B	chr19	39870606	+	1222	215	65	763	232
ENST00000537245	PLEKHG5	chr1	6556553	-	ENST00000314471	SAMD4B	chr19	39870606	+	2169	215	65	769	234

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000377748	ENST00000598913	PLEKHG5	chr1	6556553	-	SAMD4B	chr19	39870606	+	0.3701211	0.62987894
ENST00000377748	ENST00000314471	PLEKHG5	chr1	6556553	-	SAMD4B	chr19	39870606	+	0.62357855	0.37642145
ENST00000377732	ENST00000598913	PLEKHG5	chr1	6556553	-	SAMD4B	chr19	39870606	+	0.34921688	0.6507831
ENST00000377732	ENST00000314471	PLEKHG5	chr1	6556553	-	SAMD4B	chr19	39870606	+	0.7605349	0.23946509
ENST00000400915	ENST00000598913	PLEKHG5	chr1	6556553	-	SAMD4B	chr19	39870606	+	0.32402006	0.67598
ENST00000400915	ENST00000314471	PLEKHG5	chr1	6556553	-	SAMD4B	chr19	39870606	+	0.758156	0.24184397
ENST00000377740	ENST00000598913	PLEKHG5	chr1	6556553	-	SAMD4B	chr19	39870606	+	0.41706133	0.58293873
ENST00000377740	ENST00000314471	PLEKHG5	chr1	6556553	-	SAMD4B	chr19	39870606	+	0.6414901	0.35850987
ENST00000537245	ENST00000598913	PLEKHG5	chr1	6556553	-	SAMD4B	chr19	39870606	+	0.420328	0.579672
ENST00000537245	ENST00000314471	PLEKHG5	chr1	6556553	-	SAMD4B	chr19	39870606	+	0.655182	0.34481803

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Fusion Genomic Features for PLEKHG5-SAMD4B

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
PLEKHG5	chr1	6550504	-	SAMD4B	chr19	39870605	+	6.47E-05	0.99993527
PLEKHG5	chr1	6556552	-	SAMD4B	chr19	39870605	+	2.01E-07	0.99999976
PLEKHG5	chr1	6550504	-	SAMD4B	chr19	39870605	+	6.47E-05	0.99993527
PLEKHG5	chr1	6556552	-	SAMD4B	chr19	39870605	+	2.01E-07	0.99999976

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PLEKHG5-SAMD4B

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:6550505/chr19:39870606)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PLEKHG5

chr1:6556553

chr19:39870606

ENST00000377748

38_43

1084.0

Compositional bias

Note=Poly-Glu

Hgene

PLEKHG5

chr1:6556553

chr19:39870606

ENST00000537245

38_43

1086.0

Compositional bias

Note=Poly-Glu

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PLEKHG5

chr1:6556553

chr19:39870606

ENST00000340850

38_43

1007.0

Compositional bias

Note=Poly-Glu

Hgene

PLEKHG5

chr1:6556553

chr19:39870606

ENST00000377725

38_43

1020.6666666666666

Compositional bias

Note=Poly-Glu

Hgene

PLEKHG5

chr1:6556553

chr19:39870606

ENST00000377728

38_43

1007.0

Compositional bias

Note=Poly-Glu

Hgene

PLEKHG5

chr1:6556553

chr19:39870606

ENST00000377732

38_43

1044.0

Compositional bias

Note=Poly-Glu

Hgene

PLEKHG5

chr1:6556553

chr19:39870606

ENST00000377737

38_43

1007.0

Compositional bias

Note=Poly-Glu

Hgene

PLEKHG5

chr1:6556553

chr19:39870606

ENST00000400913

38_43

1007.0

Compositional bias

Note=Poly-Glu

Hgene

PLEKHG5

chr1:6556553

chr19:39870606

ENST00000400915

38_43

1063.0

Compositional bias

Note=Poly-Glu

Hgene

PLEKHG5

chr1:6556553

chr19:39870606

ENST00000535355

38_43

1076.0

Compositional bias

Note=Poly-Glu

Hgene

PLEKHG5

chr1:6556553

chr19:39870606

ENST00000544978

38_43

931.0

Compositional bias

Note=Poly-Glu

Hgene

PLEKHG5

chr1:6556553

chr19:39870606

ENST00000340850

336_528

1007.0

Domain

Hgene

PLEKHG5

chr1:6556553

chr19:39870606

ENST00000340850

584_684

1007.0

Domain

Hgene

PLEKHG5

chr1:6556553

chr19:39870606

ENST00000377725

336_528

1020.6666666666666

Domain

Hgene

PLEKHG5

chr1:6556553

chr19:39870606

ENST00000377725

584_684

1020.6666666666666

Domain

Hgene

PLEKHG5

chr1:6556553

chr19:39870606

ENST00000377728

336_528

1007.0

Domain

Hgene

PLEKHG5

chr1:6556553

chr19:39870606

ENST00000377728

584_684

1007.0

Domain

Hgene

PLEKHG5

chr1:6556553

chr19:39870606

ENST00000377732

336_528

1044.0

Domain

Hgene

PLEKHG5

chr1:6556553

chr19:39870606

ENST00000377732

584_684

1044.0

Domain

Hgene

PLEKHG5

chr1:6556553

chr19:39870606

ENST00000377737

336_528

1007.0

Domain

Hgene

PLEKHG5

chr1:6556553

chr19:39870606

ENST00000377737

584_684

1007.0

Domain

Hgene

PLEKHG5

chr1:6556553

chr19:39870606

ENST00000377748

336_528

1084.0

Domain

Hgene

PLEKHG5

chr1:6556553

chr19:39870606

ENST00000377748

584_684

1084.0

Domain

Hgene

PLEKHG5

chr1:6556553

chr19:39870606

ENST00000400913

336_528

1007.0

Domain

Hgene

PLEKHG5

chr1:6556553

chr19:39870606

ENST00000400913

584_684

1007.0

Domain

Hgene

PLEKHG5

chr1:6556553

chr19:39870606

ENST00000400915

336_528

1063.0

Domain

Hgene

PLEKHG5

chr1:6556553

chr19:39870606

ENST00000400915

584_684

1063.0

Domain

Hgene

PLEKHG5

chr1:6556553

chr19:39870606

ENST00000535355

336_528

1076.0

Domain

Hgene

PLEKHG5

chr1:6556553

chr19:39870606

ENST00000535355

584_684

1076.0

Domain

Hgene

PLEKHG5

chr1:6556553

chr19:39870606

ENST00000537245

336_528

1086.0

Domain

Hgene

PLEKHG5

chr1:6556553

chr19:39870606

ENST00000537245

584_684

1086.0

Domain

Hgene

PLEKHG5

chr1:6556553

chr19:39870606

ENST00000544978

336_528

931.0

Domain

Hgene

PLEKHG5

chr1:6556553

chr19:39870606

ENST00000544978

584_684

931.0

Domain

Tgene

SAMD4B

chr1:6556553

chr19:39870606

ENST00000314471

299_372

510

695.0

Domain

Note=SAM

Top

Fusion Gene Sequence for PLEKHG5-SAMD4B

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>66278_66278_1_PLEKHG5-SAMD4B_PLEKHG5_chr1_6556553_ENST00000377732_SAMD4B_chr19_39870606_ENST00000314471_length(transcript)=2158nt_BP=204nt
GGACGCTGACCTCTTTTGAAGGGAGGACTGAGGAGATCACCCCACCCCTCCTCCGGTTGGGAGGCCAGTGGGGCCCAGGGGAGCCTGGGT
GCCCCGCTGACTGATGCCCTCTGCTCCTCCCCTGCAGACGACCAGAGCCCCGCTGAAAAGAAGGGACTGCGCTGTCAGAACCCCGCCTGC
ATGGACAAGGGGCGGGCGGCCAAGGCTTTCACGGAGACGCAGAAGAAACGGCTGCTATCCTGGAAACAGCAAGTGCTGAAGCTCCTCCGG
ACATTCCCGCGCAAAGCCGCACTAGAGATGCAGAACTACCGGCAGCAGAAAGGCTGGGCATTCGGCTCCAACTCGCTCCCCATAGCTGGC
TCTGTGGGGATGGGAGTGGCCCGGCGTACCCAGCGGCAGTTCCCAATGCCTCCCCGGGCCCTCCCACCCGGCCGGATGGGCCTCCTGAGC
CCCTCGGGCATTGGGGGTGTCTCCCCTCGACATGCCCTCACCAGCCCCAGCCTTGGAGGCCAGGGCCGACAGAACCTGTGGTTTGCCAAC
CCTGGAGGCAGCAACAGCATGCCCAGTCAGAGCCGCAGCTCTGTGCAGCGCACCCACTCGCTCCCGGTCCACTCGTCACCCCAGGCCATT
CTCATGTTCCCTCCAGACTGCCCGGTTCCTGGGCCTGACCTGGAGATCAATCCCACTCTGGAGTCTCTGTGTCTGAGCATGACAGAACAC
GCCTTGGGTGATGGGACAGACAAAACCTCCACCATCTGACGGGACCCACAGCCCAGCGCACCCATAGGCTCCCTGGGCGGCGGGCGGGGG
CCAACCCCCAACGGGCTTCTCCGCGACAGCGAGAGGGTGGGCTGGCTCAGCTATATATTCTAATATTTTTCTACTCTCTTACCCTCTTAA
CTTTTGTTTAACATTGGCACATGCCTTGCTCACTCCCAGGCCCGTCGAGGGATCTCTGCTGAGGCCCGGGGAGTTGGGGGCAGCCAGGAT
AAAGGGGGCAGGGACTGGCCAGACTGCCTGCCTCTCTCCTTTCCTTCCTCATCCCCACCTGGTCCCATCCCACCCCTGCCTCCTCCAGAC
CGCTGACCACCTGCCTCTCCCCAAGGGAGCAGACTCCCCAGAGACAAACTGACCACTACCTTGTGGAGCCTGCTCAGAAACATTTGACAT
TTGGGGTGACGCGCAGGGCAGAGAACCTGCCCTCCAGAATGTTATTGAGAGGAGCTGGGGAGAAGGAAGGGGAGCAAGGAGAGGAAGCTC
TCTCTCCTCTCCCTGCTTCCCCTTCACCATTCCCCACATTCTGCAAGGACAGGAGCCACCTTCCTCTCTCTCACCTCCCCTGGCCCTGTT
CACCAGAGGTTCTCTATGATTAATTTCTTAGGCCTATTTAAGATACATATTTATATAGTTCTTAACGGTTTTTCTCTGATCATTTCCTCT
CATTTTTAGAATCCCCAGGTCTCTCTCAGCCAAGACAGTGGCAGGGAGAGCCTGAACTTTATGAGGGGAGAGGGCAGAGCCCCCTCCTCC
AGACCCTCAAGCTCTAACCCATTTTCCTCCAGCCCTGGCTACCCGGATGAAGAGGTTGGAGGTGGGCAGCCAGGGTAGCCAGTGAGGTCA
GGAAGTCTGTTGCCTTAACGTCCCCTTCCCCACGAACACACACCCTTCTCCGCTCCCAGGTCTGGTTGGTGAGACTTGGGAGTCAGGAAT
AAGGGAAAGGGGATTGTTTGGTTTTTGGGTTTTTCCCTAAGCCCCTCCCTTTTCTTTCAGCCTTTTTCCTTCCCCCATTATGTCATGACC
TCACTTAAGTGGAACACTATATCATAACCCAGAGATTCGTCCCAGCCCCAGAGTCCGACAGACTGTCTGGTCCCTATTCCTAATGAGGGG
TTGTGTTGGGGCCCAGGTGGAGGGAGGGGATTTGGGGGTTCAGACTGCGGGGAAGCCAGGGTCTCCCTCTTCAACGCCCTCCTCCCCCTC
AACCCACCTTCCCAACTGGGACATTCTCAAGCTTTTCACACCGAAAAGGAAAAAAAATGTTATTTTTAGATACATTTTATGAATAACTTT

>66278_66278_1_PLEKHG5-SAMD4B_PLEKHG5_chr1_6556553_ENST00000377732_SAMD4B_chr19_39870606_ENST00000314471_length(amino acids)=247AA_BP=63
MKGGLRRSPHPSSGWEASGAQGSLGAPLTDALCSSPADDQSPAEKKGLRCQNPACMDKGRAAKAFTETQKKRLLSWKQQVLKLLRTFPRK
AALEMQNYRQQKGWAFGSNSLPIAGSVGMGVARRTQRQFPMPPRALPPGRMGLLSPSGIGGVSPRHALTSPSLGGQGRQNLWFANPGGSN

--------------------------------------------------------------
>66278_66278_2_PLEKHG5-SAMD4B_PLEKHG5_chr1_6556553_ENST00000377732_SAMD4B_chr19_39870606_ENST00000598913_length(transcript)=1211nt_BP=204nt
GGACGCTGACCTCTTTTGAAGGGAGGACTGAGGAGATCACCCCACCCCTCCTCCGGTTGGGAGGCCAGTGGGGCCCAGGGGAGCCTGGGT
GCCCCGCTGACTGATGCCCTCTGCTCCTCCCCTGCAGACGACCAGAGCCCCGCTGAAAAGAAGGGACTGCGCTGTCAGAACCCCGCCTGC
ATGGACAAGGGGCGGGCGGCCAAGGCTTTCACGGAGACGCAGAAGAAACGGCTGCTATCCTGGAAACAGCAAGTGCTGAAGCTCCTCCGG
ACATTCCCGCGCAAAGCCGCACTAGAGATGCAGAACTACCGGCAGCAGAAAGGCTGGGCATTCGGCTCCAACTCGCTCCCCATAGCTGGC
TCTGTGGGGATGGGAGTGGCCCGGCGTACCCAGCGGCAGTTCCCAATGCCTCCCCGGGCCCTCCCACCCGGCCGGATGGGCCTCCTGAGC
CCCTCGGGCATTGGGGGTGTCTCCCCTCGACATGCCCTCACCAGCCCCAGCCTTGGAGGCCAGGGCCGACAGAACCTGTGGTTTGCCAAC
CCTGGAGGCAGCAACAGCATGCCCAGTCAGAGCCGCAGCTCTGTGCAGCGCACCCACTCGCTCCCGGTCCACTCGTCACCCCAGGCCATT
CTCATGTTCCCTCCAGACTGCCCGGTTCCTGGGCCTGACCTGGAGATCAATCCCACTCTGGAGTCTCTGTGTCTGAGCATGACAGAACAC
GCCTTGGGTGGCCCGTCGAGGGATCTCTGCTGAGGCCCGGGGAGTTGGGGGCAGCCAGGATAAAGGGGGCAGGGACTGGCCAGACTGCCT
GCCTCTCTCCTTTCCTTCCTCATCCCCACCTGGTCCCATCCCACCCCTGCCTCCTCCAGACCGCTGACCACCTGCCTCTCCCCAAGGGAG
CAGACTCCCCAGAGACAAACTGACCACTACCTTGTGGAGCCTGCTCAGAAACATTTGACATTTGGGGTGACGCGCAGGGCAGAGAACCTG
CCCTCCAGAATGTTATTGAGAGGAGCTGGGGAGAAGGAAGGGGAGCAAGGAGAGGAAGCTCTCTCTCCTCTCCCTGCTTCCCCTTCACCA
TTCCCCACATTCTGCAAGGACAGGAGCCACCTTCCTCTCTCTCACCTCCCCTGGCCCTGTTCACCAGAGGTTCTCTATGATTAATTTCTT

>66278_66278_2_PLEKHG5-SAMD4B_PLEKHG5_chr1_6556553_ENST00000377732_SAMD4B_chr19_39870606_ENST00000598913_length(amino acids)=245AA_BP=63
MKGGLRRSPHPSSGWEASGAQGSLGAPLTDALCSSPADDQSPAEKKGLRCQNPACMDKGRAAKAFTETQKKRLLSWKQQVLKLLRTFPRK
AALEMQNYRQQKGWAFGSNSLPIAGSVGMGVARRTQRQFPMPPRALPPGRMGLLSPSGIGGVSPRHALTSPSLGGQGRQNLWFANPGGSN

--------------------------------------------------------------
>66278_66278_3_PLEKHG5-SAMD4B_PLEKHG5_chr1_6556553_ENST00000377740_SAMD4B_chr19_39870606_ENST00000314471_length(transcript)=2648nt_BP=694nt
CTTGATCTCCCGCTGTGACCAGCCCCTCTCTGCCTGGCAGGGGAAAGCCACCAAACTAAGGCCTTCCTGGTAGCCAAGGAGCCCAGCAGA
GGGGCTGCTGCTGGCTGCTGGGATTGCAGAGGCCGGGGTCTCTGTGGTGTTGCTTTCCTGGAAAGGAGGGACGGCACCTCCAGGGCAGCC
AGCAGTGTGGGAGCCCATTCCAGGGCGCAAATGGGCACTCAGGAATGGAAAATCCAAGAAGGAACCAACCACCAACAAGGAAATGCAGTG
TGAGCGGCGGCTGCGAAGTCTGTGCCTTCAAATATACAGCGCCCAGGGGACCTGTGTTGGACGGGGAGCAAATTGGCAGGGCTGAGAGCG
CCTTGGTTTTCTGTGCAGACAGGTCCAGCTGCAGAAATTAAGACTGGGGCTGAGTCGGGGAGAAGCCTTCCATGTTGAGATGGCAACTGG
GCAAAGCAGGACGGAGACCTGTGTGTCTGATTAGAGAGGCCTGTGGCATTGGCATGTGGCTGGAGGTCCAGGCAGGGTGCCACCACCGCA
GAGGTCAAGCATGAATTCAGTCCTGACAAAACATGGGTCTCCACCTCGAAGCTGGCTCAGCCTTTGTTCAGGAACCGACGACCAGAGCCC
CGCTGAAAAGAAGGGACTGCGCTGTCAGAACCCCGCCTGCATGGACAAGGGGCGGGCGGCCAAGGCTTTCACGGAGACGCAGAAGAAACG
GCTGCTATCCTGGAAACAGCAAGTGCTGAAGCTCCTCCGGACATTCCCGCGCAAAGCCGCACTAGAGATGCAGAACTACCGGCAGCAGAA
AGGCTGGGCATTCGGCTCCAACTCGCTCCCCATAGCTGGCTCTGTGGGGATGGGAGTGGCCCGGCGTACCCAGCGGCAGTTCCCAATGCC
TCCCCGGGCCCTCCCACCCGGCCGGATGGGCCTCCTGAGCCCCTCGGGCATTGGGGGTGTCTCCCCTCGACATGCCCTCACCAGCCCCAG
CCTTGGAGGCCAGGGCCGACAGAACCTGTGGTTTGCCAACCCTGGAGGCAGCAACAGCATGCCCAGTCAGAGCCGCAGCTCTGTGCAGCG
CACCCACTCGCTCCCGGTCCACTCGTCACCCCAGGCCATTCTCATGTTCCCTCCAGACTGCCCGGTTCCTGGGCCTGACCTGGAGATCAA
TCCCACTCTGGAGTCTCTGTGTCTGAGCATGACAGAACACGCCTTGGGTGATGGGACAGACAAAACCTCCACCATCTGACGGGACCCACA
GCCCAGCGCACCCATAGGCTCCCTGGGCGGCGGGCGGGGGCCAACCCCCAACGGGCTTCTCCGCGACAGCGAGAGGGTGGGCTGGCTCAG
CTATATATTCTAATATTTTTCTACTCTCTTACCCTCTTAACTTTTGTTTAACATTGGCACATGCCTTGCTCACTCCCAGGCCCGTCGAGG
GATCTCTGCTGAGGCCCGGGGAGTTGGGGGCAGCCAGGATAAAGGGGGCAGGGACTGGCCAGACTGCCTGCCTCTCTCCTTTCCTTCCTC
ATCCCCACCTGGTCCCATCCCACCCCTGCCTCCTCCAGACCGCTGACCACCTGCCTCTCCCCAAGGGAGCAGACTCCCCAGAGACAAACT
GACCACTACCTTGTGGAGCCTGCTCAGAAACATTTGACATTTGGGGTGACGCGCAGGGCAGAGAACCTGCCCTCCAGAATGTTATTGAGA
GGAGCTGGGGAGAAGGAAGGGGAGCAAGGAGAGGAAGCTCTCTCTCCTCTCCCTGCTTCCCCTTCACCATTCCCCACATTCTGCAAGGAC
AGGAGCCACCTTCCTCTCTCTCACCTCCCCTGGCCCTGTTCACCAGAGGTTCTCTATGATTAATTTCTTAGGCCTATTTAAGATACATAT
TTATATAGTTCTTAACGGTTTTTCTCTGATCATTTCCTCTCATTTTTAGAATCCCCAGGTCTCTCTCAGCCAAGACAGTGGCAGGGAGAG
CCTGAACTTTATGAGGGGAGAGGGCAGAGCCCCCTCCTCCAGACCCTCAAGCTCTAACCCATTTTCCTCCAGCCCTGGCTACCCGGATGA
AGAGGTTGGAGGTGGGCAGCCAGGGTAGCCAGTGAGGTCAGGAAGTCTGTTGCCTTAACGTCCCCTTCCCCACGAACACACACCCTTCTC
CGCTCCCAGGTCTGGTTGGTGAGACTTGGGAGTCAGGAATAAGGGAAAGGGGATTGTTTGGTTTTTGGGTTTTTCCCTAAGCCCCTCCCT
TTTCTTTCAGCCTTTTTCCTTCCCCCATTATGTCATGACCTCACTTAAGTGGAACACTATATCATAACCCAGAGATTCGTCCCAGCCCCA
GAGTCCGACAGACTGTCTGGTCCCTATTCCTAATGAGGGGTTGTGTTGGGGCCCAGGTGGAGGGAGGGGATTTGGGGGTTCAGACTGCGG
GGAAGCCAGGGTCTCCCTCTTCAACGCCCTCCTCCCCCTCAACCCACCTTCCCAACTGGGACATTCTCAAGCTTTTCACACCGAAAAGGA
AAAAAAATGTTATTTTTAGATACATTTTATGAATAACTTTTGTTATGAATATGGCTGGTAACCATTGTGTATGTTATTAAAGATACAAAA

>66278_66278_3_PLEKHG5-SAMD4B_PLEKHG5_chr1_6556553_ENST00000377740_SAMD4B_chr19_39870606_ENST00000314471_length(amino acids)=252AA_BP=68
MWHWHVAGGPGRVPPPQRSSMNSVLTKHGSPPRSWLSLCSGTDDQSPAEKKGLRCQNPACMDKGRAAKAFTETQKKRLLSWKQQVLKLLR
TFPRKAALEMQNYRQQKGWAFGSNSLPIAGSVGMGVARRTQRQFPMPPRALPPGRMGLLSPSGIGGVSPRHALTSPSLGGQGRQNLWFAN

--------------------------------------------------------------
>66278_66278_4_PLEKHG5-SAMD4B_PLEKHG5_chr1_6556553_ENST00000377740_SAMD4B_chr19_39870606_ENST00000598913_length(transcript)=1701nt_BP=694nt
CTTGATCTCCCGCTGTGACCAGCCCCTCTCTGCCTGGCAGGGGAAAGCCACCAAACTAAGGCCTTCCTGGTAGCCAAGGAGCCCAGCAGA
GGGGCTGCTGCTGGCTGCTGGGATTGCAGAGGCCGGGGTCTCTGTGGTGTTGCTTTCCTGGAAAGGAGGGACGGCACCTCCAGGGCAGCC
AGCAGTGTGGGAGCCCATTCCAGGGCGCAAATGGGCACTCAGGAATGGAAAATCCAAGAAGGAACCAACCACCAACAAGGAAATGCAGTG
TGAGCGGCGGCTGCGAAGTCTGTGCCTTCAAATATACAGCGCCCAGGGGACCTGTGTTGGACGGGGAGCAAATTGGCAGGGCTGAGAGCG
CCTTGGTTTTCTGTGCAGACAGGTCCAGCTGCAGAAATTAAGACTGGGGCTGAGTCGGGGAGAAGCCTTCCATGTTGAGATGGCAACTGG
GCAAAGCAGGACGGAGACCTGTGTGTCTGATTAGAGAGGCCTGTGGCATTGGCATGTGGCTGGAGGTCCAGGCAGGGTGCCACCACCGCA
GAGGTCAAGCATGAATTCAGTCCTGACAAAACATGGGTCTCCACCTCGAAGCTGGCTCAGCCTTTGTTCAGGAACCGACGACCAGAGCCC
CGCTGAAAAGAAGGGACTGCGCTGTCAGAACCCCGCCTGCATGGACAAGGGGCGGGCGGCCAAGGCTTTCACGGAGACGCAGAAGAAACG
GCTGCTATCCTGGAAACAGCAAGTGCTGAAGCTCCTCCGGACATTCCCGCGCAAAGCCGCACTAGAGATGCAGAACTACCGGCAGCAGAA
AGGCTGGGCATTCGGCTCCAACTCGCTCCCCATAGCTGGCTCTGTGGGGATGGGAGTGGCCCGGCGTACCCAGCGGCAGTTCCCAATGCC
TCCCCGGGCCCTCCCACCCGGCCGGATGGGCCTCCTGAGCCCCTCGGGCATTGGGGGTGTCTCCCCTCGACATGCCCTCACCAGCCCCAG
CCTTGGAGGCCAGGGCCGACAGAACCTGTGGTTTGCCAACCCTGGAGGCAGCAACAGCATGCCCAGTCAGAGCCGCAGCTCTGTGCAGCG
CACCCACTCGCTCCCGGTCCACTCGTCACCCCAGGCCATTCTCATGTTCCCTCCAGACTGCCCGGTTCCTGGGCCTGACCTGGAGATCAA
TCCCACTCTGGAGTCTCTGTGTCTGAGCATGACAGAACACGCCTTGGGTGGCCCGTCGAGGGATCTCTGCTGAGGCCCGGGGAGTTGGGG
GCAGCCAGGATAAAGGGGGCAGGGACTGGCCAGACTGCCTGCCTCTCTCCTTTCCTTCCTCATCCCCACCTGGTCCCATCCCACCCCTGC
CTCCTCCAGACCGCTGACCACCTGCCTCTCCCCAAGGGAGCAGACTCCCCAGAGACAAACTGACCACTACCTTGTGGAGCCTGCTCAGAA
ACATTTGACATTTGGGGTGACGCGCAGGGCAGAGAACCTGCCCTCCAGAATGTTATTGAGAGGAGCTGGGGAGAAGGAAGGGGAGCAAGG
AGAGGAAGCTCTCTCTCCTCTCCCTGCTTCCCCTTCACCATTCCCCACATTCTGCAAGGACAGGAGCCACCTTCCTCTCTCTCACCTCCC

>66278_66278_4_PLEKHG5-SAMD4B_PLEKHG5_chr1_6556553_ENST00000377740_SAMD4B_chr19_39870606_ENST00000598913_length(amino acids)=250AA_BP=68
MWHWHVAGGPGRVPPPQRSSMNSVLTKHGSPPRSWLSLCSGTDDQSPAEKKGLRCQNPACMDKGRAAKAFTETQKKRLLSWKQQVLKLLR
TFPRKAALEMQNYRQQKGWAFGSNSLPIAGSVGMGVARRTQRQFPMPPRALPPGRMGLLSPSGIGGVSPRHALTSPSLGGQGRQNLWFAN

--------------------------------------------------------------
>66278_66278_5_PLEKHG5-SAMD4B_PLEKHG5_chr1_6556553_ENST00000377748_SAMD4B_chr19_39870606_ENST00000314471_length(transcript)=2596nt_BP=642nt
AAACTAAGGCCTTCCTGGTAGCCAAGGAGCCCAGCAGAGGGGCTGCTGCTGGCTGCTGGGATTGCAGAGGCCGGGGTCTCTGTGGTGTTG
CTTTCCTGGAAAGGAGGGACGGCACCTCCAGGGCAGCCAGCAGTGTGGGAGCCCATTCCAGGGCGCAAATGGGCACTCAGGAATGGAAAA
TCCAAGAAGGAACCAACCACCAACAAGGAAATGCAGTGTGAGCGGCGGCTGCGAAGTCTGTGCCTTCAAATATACAGCGCCCAGGGGACC
TGTGTTGGACGGGGAGCAAATTGGCAGGGCTGAGAGCGCCTTGGTTTTCTGTGCAGACAGGTCCAGCTGCAGAAATTAAGACTGGGGCTG
AGTCGGGGAGAAGCCTTCCATGTTGAGATGGCAACTGGGCAAAGCAGGACGGAGACCTGTGTGTCTGATTAGAGAGGCCTGTGGCATTGG
CATGTGGCTGGAGGTCCAGGCAGGGTGCCACCACCGCAGAGGTCAAGCATGAATTCAGTCCTGACAAAACATGGGTCTCCACCTCGAAGC
TGGCTCAGCCTTTGTTCAGGAACCGACGACCAGAGCCCCGCTGAAAAGAAGGGACTGCGCTGTCAGAACCCCGCCTGCATGGACAAGGGG
CGGGCGGCCAAGGCTTTCACGGAGACGCAGAAGAAACGGCTGCTATCCTGGAAACAGCAAGTGCTGAAGCTCCTCCGGACATTCCCGCGC
AAAGCCGCACTAGAGATGCAGAACTACCGGCAGCAGAAAGGCTGGGCATTCGGCTCCAACTCGCTCCCCATAGCTGGCTCTGTGGGGATG
GGAGTGGCCCGGCGTACCCAGCGGCAGTTCCCAATGCCTCCCCGGGCCCTCCCACCCGGCCGGATGGGCCTCCTGAGCCCCTCGGGCATT
GGGGGTGTCTCCCCTCGACATGCCCTCACCAGCCCCAGCCTTGGAGGCCAGGGCCGACAGAACCTGTGGTTTGCCAACCCTGGAGGCAGC
AACAGCATGCCCAGTCAGAGCCGCAGCTCTGTGCAGCGCACCCACTCGCTCCCGGTCCACTCGTCACCCCAGGCCATTCTCATGTTCCCT
CCAGACTGCCCGGTTCCTGGGCCTGACCTGGAGATCAATCCCACTCTGGAGTCTCTGTGTCTGAGCATGACAGAACACGCCTTGGGTGAT
GGGACAGACAAAACCTCCACCATCTGACGGGACCCACAGCCCAGCGCACCCATAGGCTCCCTGGGCGGCGGGCGGGGGCCAACCCCCAAC
GGGCTTCTCCGCGACAGCGAGAGGGTGGGCTGGCTCAGCTATATATTCTAATATTTTTCTACTCTCTTACCCTCTTAACTTTTGTTTAAC
ATTGGCACATGCCTTGCTCACTCCCAGGCCCGTCGAGGGATCTCTGCTGAGGCCCGGGGAGTTGGGGGCAGCCAGGATAAAGGGGGCAGG
GACTGGCCAGACTGCCTGCCTCTCTCCTTTCCTTCCTCATCCCCACCTGGTCCCATCCCACCCCTGCCTCCTCCAGACCGCTGACCACCT
GCCTCTCCCCAAGGGAGCAGACTCCCCAGAGACAAACTGACCACTACCTTGTGGAGCCTGCTCAGAAACATTTGACATTTGGGGTGACGC
GCAGGGCAGAGAACCTGCCCTCCAGAATGTTATTGAGAGGAGCTGGGGAGAAGGAAGGGGAGCAAGGAGAGGAAGCTCTCTCTCCTCTCC
CTGCTTCCCCTTCACCATTCCCCACATTCTGCAAGGACAGGAGCCACCTTCCTCTCTCTCACCTCCCCTGGCCCTGTTCACCAGAGGTTC
TCTATGATTAATTTCTTAGGCCTATTTAAGATACATATTTATATAGTTCTTAACGGTTTTTCTCTGATCATTTCCTCTCATTTTTAGAAT
CCCCAGGTCTCTCTCAGCCAAGACAGTGGCAGGGAGAGCCTGAACTTTATGAGGGGAGAGGGCAGAGCCCCCTCCTCCAGACCCTCAAGC
TCTAACCCATTTTCCTCCAGCCCTGGCTACCCGGATGAAGAGGTTGGAGGTGGGCAGCCAGGGTAGCCAGTGAGGTCAGGAAGTCTGTTG
CCTTAACGTCCCCTTCCCCACGAACACACACCCTTCTCCGCTCCCAGGTCTGGTTGGTGAGACTTGGGAGTCAGGAATAAGGGAAAGGGG
ATTGTTTGGTTTTTGGGTTTTTCCCTAAGCCCCTCCCTTTTCTTTCAGCCTTTTTCCTTCCCCCATTATGTCATGACCTCACTTAAGTGG
AACACTATATCATAACCCAGAGATTCGTCCCAGCCCCAGAGTCCGACAGACTGTCTGGTCCCTATTCCTAATGAGGGGTTGTGTTGGGGC
CCAGGTGGAGGGAGGGGATTTGGGGGTTCAGACTGCGGGGAAGCCAGGGTCTCCCTCTTCAACGCCCTCCTCCCCCTCAACCCACCTTCC
CAACTGGGACATTCTCAAGCTTTTCACACCGAAAAGGAAAAAAAATGTTATTTTTAGATACATTTTATGAATAACTTTTGTTATGAATAT

>66278_66278_5_PLEKHG5-SAMD4B_PLEKHG5_chr1_6556553_ENST00000377748_SAMD4B_chr19_39870606_ENST00000314471_length(amino acids)=252AA_BP=68
MWHWHVAGGPGRVPPPQRSSMNSVLTKHGSPPRSWLSLCSGTDDQSPAEKKGLRCQNPACMDKGRAAKAFTETQKKRLLSWKQQVLKLLR
TFPRKAALEMQNYRQQKGWAFGSNSLPIAGSVGMGVARRTQRQFPMPPRALPPGRMGLLSPSGIGGVSPRHALTSPSLGGQGRQNLWFAN

--------------------------------------------------------------
>66278_66278_6_PLEKHG5-SAMD4B_PLEKHG5_chr1_6556553_ENST00000377748_SAMD4B_chr19_39870606_ENST00000598913_length(transcript)=1649nt_BP=642nt
AAACTAAGGCCTTCCTGGTAGCCAAGGAGCCCAGCAGAGGGGCTGCTGCTGGCTGCTGGGATTGCAGAGGCCGGGGTCTCTGTGGTGTTG
CTTTCCTGGAAAGGAGGGACGGCACCTCCAGGGCAGCCAGCAGTGTGGGAGCCCATTCCAGGGCGCAAATGGGCACTCAGGAATGGAAAA
TCCAAGAAGGAACCAACCACCAACAAGGAAATGCAGTGTGAGCGGCGGCTGCGAAGTCTGTGCCTTCAAATATACAGCGCCCAGGGGACC
TGTGTTGGACGGGGAGCAAATTGGCAGGGCTGAGAGCGCCTTGGTTTTCTGTGCAGACAGGTCCAGCTGCAGAAATTAAGACTGGGGCTG
AGTCGGGGAGAAGCCTTCCATGTTGAGATGGCAACTGGGCAAAGCAGGACGGAGACCTGTGTGTCTGATTAGAGAGGCCTGTGGCATTGG
CATGTGGCTGGAGGTCCAGGCAGGGTGCCACCACCGCAGAGGTCAAGCATGAATTCAGTCCTGACAAAACATGGGTCTCCACCTCGAAGC
TGGCTCAGCCTTTGTTCAGGAACCGACGACCAGAGCCCCGCTGAAAAGAAGGGACTGCGCTGTCAGAACCCCGCCTGCATGGACAAGGGG
CGGGCGGCCAAGGCTTTCACGGAGACGCAGAAGAAACGGCTGCTATCCTGGAAACAGCAAGTGCTGAAGCTCCTCCGGACATTCCCGCGC
AAAGCCGCACTAGAGATGCAGAACTACCGGCAGCAGAAAGGCTGGGCATTCGGCTCCAACTCGCTCCCCATAGCTGGCTCTGTGGGGATG
GGAGTGGCCCGGCGTACCCAGCGGCAGTTCCCAATGCCTCCCCGGGCCCTCCCACCCGGCCGGATGGGCCTCCTGAGCCCCTCGGGCATT
GGGGGTGTCTCCCCTCGACATGCCCTCACCAGCCCCAGCCTTGGAGGCCAGGGCCGACAGAACCTGTGGTTTGCCAACCCTGGAGGCAGC
AACAGCATGCCCAGTCAGAGCCGCAGCTCTGTGCAGCGCACCCACTCGCTCCCGGTCCACTCGTCACCCCAGGCCATTCTCATGTTCCCT
CCAGACTGCCCGGTTCCTGGGCCTGACCTGGAGATCAATCCCACTCTGGAGTCTCTGTGTCTGAGCATGACAGAACACGCCTTGGGTGGC
CCGTCGAGGGATCTCTGCTGAGGCCCGGGGAGTTGGGGGCAGCCAGGATAAAGGGGGCAGGGACTGGCCAGACTGCCTGCCTCTCTCCTT
TCCTTCCTCATCCCCACCTGGTCCCATCCCACCCCTGCCTCCTCCAGACCGCTGACCACCTGCCTCTCCCCAAGGGAGCAGACTCCCCAG
AGACAAACTGACCACTACCTTGTGGAGCCTGCTCAGAAACATTTGACATTTGGGGTGACGCGCAGGGCAGAGAACCTGCCCTCCAGAATG
TTATTGAGAGGAGCTGGGGAGAAGGAAGGGGAGCAAGGAGAGGAAGCTCTCTCTCCTCTCCCTGCTTCCCCTTCACCATTCCCCACATTC
TGCAAGGACAGGAGCCACCTTCCTCTCTCTCACCTCCCCTGGCCCTGTTCACCAGAGGTTCTCTATGATTAATTTCTTAGGCCTATTTAA

>66278_66278_6_PLEKHG5-SAMD4B_PLEKHG5_chr1_6556553_ENST00000377748_SAMD4B_chr19_39870606_ENST00000598913_length(amino acids)=250AA_BP=68
MWHWHVAGGPGRVPPPQRSSMNSVLTKHGSPPRSWLSLCSGTDDQSPAEKKGLRCQNPACMDKGRAAKAFTETQKKRLLSWKQQVLKLLR
TFPRKAALEMQNYRQQKGWAFGSNSLPIAGSVGMGVARRTQRQFPMPPRALPPGRMGLLSPSGIGGVSPRHALTSPSLGGQGRQNLWFAN

--------------------------------------------------------------
>66278_66278_7_PLEKHG5-SAMD4B_PLEKHG5_chr1_6556553_ENST00000400915_SAMD4B_chr19_39870606_ENST00000314471_length(transcript)=2102nt_BP=148nt
CCCAGTCCCCGGCGTCCCCGGCGCCCCCGCCCGCCGCCCGCCCCCCGCGCGGCACGGGGCCTGCTCCATGGACGACCAGAGCCCCGCTGA
AAAGAAGGGACTGCGCTGTCAGAACCCCGCCTGCATGGACAAGGGGCGGGCGGCCAAGGCTTTCACGGAGACGCAGAAGAAACGGCTGCT
ATCCTGGAAACAGCAAGTGCTGAAGCTCCTCCGGACATTCCCGCGCAAAGCCGCACTAGAGATGCAGAACTACCGGCAGCAGAAAGGCTG
GGCATTCGGCTCCAACTCGCTCCCCATAGCTGGCTCTGTGGGGATGGGAGTGGCCCGGCGTACCCAGCGGCAGTTCCCAATGCCTCCCCG
GGCCCTCCCACCCGGCCGGATGGGCCTCCTGAGCCCCTCGGGCATTGGGGGTGTCTCCCCTCGACATGCCCTCACCAGCCCCAGCCTTGG
AGGCCAGGGCCGACAGAACCTGTGGTTTGCCAACCCTGGAGGCAGCAACAGCATGCCCAGTCAGAGCCGCAGCTCTGTGCAGCGCACCCA
CTCGCTCCCGGTCCACTCGTCACCCCAGGCCATTCTCATGTTCCCTCCAGACTGCCCGGTTCCTGGGCCTGACCTGGAGATCAATCCCAC
TCTGGAGTCTCTGTGTCTGAGCATGACAGAACACGCCTTGGGTGATGGGACAGACAAAACCTCCACCATCTGACGGGACCCACAGCCCAG
CGCACCCATAGGCTCCCTGGGCGGCGGGCGGGGGCCAACCCCCAACGGGCTTCTCCGCGACAGCGAGAGGGTGGGCTGGCTCAGCTATAT
ATTCTAATATTTTTCTACTCTCTTACCCTCTTAACTTTTGTTTAACATTGGCACATGCCTTGCTCACTCCCAGGCCCGTCGAGGGATCTC
TGCTGAGGCCCGGGGAGTTGGGGGCAGCCAGGATAAAGGGGGCAGGGACTGGCCAGACTGCCTGCCTCTCTCCTTTCCTTCCTCATCCCC
ACCTGGTCCCATCCCACCCCTGCCTCCTCCAGACCGCTGACCACCTGCCTCTCCCCAAGGGAGCAGACTCCCCAGAGACAAACTGACCAC
TACCTTGTGGAGCCTGCTCAGAAACATTTGACATTTGGGGTGACGCGCAGGGCAGAGAACCTGCCCTCCAGAATGTTATTGAGAGGAGCT
GGGGAGAAGGAAGGGGAGCAAGGAGAGGAAGCTCTCTCTCCTCTCCCTGCTTCCCCTTCACCATTCCCCACATTCTGCAAGGACAGGAGC
CACCTTCCTCTCTCTCACCTCCCCTGGCCCTGTTCACCAGAGGTTCTCTATGATTAATTTCTTAGGCCTATTTAAGATACATATTTATAT
AGTTCTTAACGGTTTTTCTCTGATCATTTCCTCTCATTTTTAGAATCCCCAGGTCTCTCTCAGCCAAGACAGTGGCAGGGAGAGCCTGAA
CTTTATGAGGGGAGAGGGCAGAGCCCCCTCCTCCAGACCCTCAAGCTCTAACCCATTTTCCTCCAGCCCTGGCTACCCGGATGAAGAGGT
TGGAGGTGGGCAGCCAGGGTAGCCAGTGAGGTCAGGAAGTCTGTTGCCTTAACGTCCCCTTCCCCACGAACACACACCCTTCTCCGCTCC
CAGGTCTGGTTGGTGAGACTTGGGAGTCAGGAATAAGGGAAAGGGGATTGTTTGGTTTTTGGGTTTTTCCCTAAGCCCCTCCCTTTTCTT
TCAGCCTTTTTCCTTCCCCCATTATGTCATGACCTCACTTAAGTGGAACACTATATCATAACCCAGAGATTCGTCCCAGCCCCAGAGTCC
GACAGACTGTCTGGTCCCTATTCCTAATGAGGGGTTGTGTTGGGGCCCAGGTGGAGGGAGGGGATTTGGGGGTTCAGACTGCGGGGAAGC
CAGGGTCTCCCTCTTCAACGCCCTCCTCCCCCTCAACCCACCTTCCCAACTGGGACATTCTCAAGCTTTTCACACCGAAAAGGAAAAAAA
ATGTTATTTTTAGATACATTTTATGAATAACTTTTGTTATGAATATGGCTGGTAACCATTGTGTATGTTATTAAAGATACAAAATGTTGG

>66278_66278_7_PLEKHG5-SAMD4B_PLEKHG5_chr1_6556553_ENST00000400915_SAMD4B_chr19_39870606_ENST00000314471_length(amino acids)=211AA_BP=27
MDDQSPAEKKGLRCQNPACMDKGRAAKAFTETQKKRLLSWKQQVLKLLRTFPRKAALEMQNYRQQKGWAFGSNSLPIAGSVGMGVARRTQ
RQFPMPPRALPPGRMGLLSPSGIGGVSPRHALTSPSLGGQGRQNLWFANPGGSNSMPSQSRSSVQRTHSLPVHSSPQAILMFPPDCPVPG

--------------------------------------------------------------
>66278_66278_8_PLEKHG5-SAMD4B_PLEKHG5_chr1_6556553_ENST00000400915_SAMD4B_chr19_39870606_ENST00000598913_length(transcript)=1155nt_BP=148nt
CCCAGTCCCCGGCGTCCCCGGCGCCCCCGCCCGCCGCCCGCCCCCCGCGCGGCACGGGGCCTGCTCCATGGACGACCAGAGCCCCGCTGA
AAAGAAGGGACTGCGCTGTCAGAACCCCGCCTGCATGGACAAGGGGCGGGCGGCCAAGGCTTTCACGGAGACGCAGAAGAAACGGCTGCT
ATCCTGGAAACAGCAAGTGCTGAAGCTCCTCCGGACATTCCCGCGCAAAGCCGCACTAGAGATGCAGAACTACCGGCAGCAGAAAGGCTG
GGCATTCGGCTCCAACTCGCTCCCCATAGCTGGCTCTGTGGGGATGGGAGTGGCCCGGCGTACCCAGCGGCAGTTCCCAATGCCTCCCCG
GGCCCTCCCACCCGGCCGGATGGGCCTCCTGAGCCCCTCGGGCATTGGGGGTGTCTCCCCTCGACATGCCCTCACCAGCCCCAGCCTTGG
AGGCCAGGGCCGACAGAACCTGTGGTTTGCCAACCCTGGAGGCAGCAACAGCATGCCCAGTCAGAGCCGCAGCTCTGTGCAGCGCACCCA
CTCGCTCCCGGTCCACTCGTCACCCCAGGCCATTCTCATGTTCCCTCCAGACTGCCCGGTTCCTGGGCCTGACCTGGAGATCAATCCCAC
TCTGGAGTCTCTGTGTCTGAGCATGACAGAACACGCCTTGGGTGGCCCGTCGAGGGATCTCTGCTGAGGCCCGGGGAGTTGGGGGCAGCC
AGGATAAAGGGGGCAGGGACTGGCCAGACTGCCTGCCTCTCTCCTTTCCTTCCTCATCCCCACCTGGTCCCATCCCACCCCTGCCTCCTC
CAGACCGCTGACCACCTGCCTCTCCCCAAGGGAGCAGACTCCCCAGAGACAAACTGACCACTACCTTGTGGAGCCTGCTCAGAAACATTT
GACATTTGGGGTGACGCGCAGGGCAGAGAACCTGCCCTCCAGAATGTTATTGAGAGGAGCTGGGGAGAAGGAAGGGGAGCAAGGAGAGGA
AGCTCTCTCTCCTCTCCCTGCTTCCCCTTCACCATTCCCCACATTCTGCAAGGACAGGAGCCACCTTCCTCTCTCTCACCTCCCCTGGCC

>66278_66278_8_PLEKHG5-SAMD4B_PLEKHG5_chr1_6556553_ENST00000400915_SAMD4B_chr19_39870606_ENST00000598913_length(amino acids)=209AA_BP=27
MDDQSPAEKKGLRCQNPACMDKGRAAKAFTETQKKRLLSWKQQVLKLLRTFPRKAALEMQNYRQQKGWAFGSNSLPIAGSVGMGVARRTQ
RQFPMPPRALPPGRMGLLSPSGIGGVSPRHALTSPSLGGQGRQNLWFANPGGSNSMPSQSRSSVQRTHSLPVHSSPQAILMFPPDCPVPG

--------------------------------------------------------------
>66278_66278_9_PLEKHG5-SAMD4B_PLEKHG5_chr1_6556553_ENST00000537245_SAMD4B_chr19_39870606_ENST00000314471_length(transcript)=2169nt_BP=215nt
ACCGCGGTGCACTCCAGCCCCCAGGAAGAGAGGCAGCTTGGAGGGGGCCAAATTCAGGGTCAAAGATGAGTCTTGGGGAACGGGGGTCGC
CCCAGACCTTCGGGGGCTCCTCTGTCTCTAAAGGGAGCGATGCAGGGCACGACCAGAGCCCCGCTGAAAAGAAGGGACTGCGCTGTCAGA
ACCCCGCCTGCATGGACAAGGGGCGGGCGGCCAAGGCTTTCACGGAGACGCAGAAGAAACGGCTGCTATCCTGGAAACAGCAAGTGCTGA
AGCTCCTCCGGACATTCCCGCGCAAAGCCGCACTAGAGATGCAGAACTACCGGCAGCAGAAAGGCTGGGCATTCGGCTCCAACTCGCTCC
CCATAGCTGGCTCTGTGGGGATGGGAGTGGCCCGGCGTACCCAGCGGCAGTTCCCAATGCCTCCCCGGGCCCTCCCACCCGGCCGGATGG
GCCTCCTGAGCCCCTCGGGCATTGGGGGTGTCTCCCCTCGACATGCCCTCACCAGCCCCAGCCTTGGAGGCCAGGGCCGACAGAACCTGT
GGTTTGCCAACCCTGGAGGCAGCAACAGCATGCCCAGTCAGAGCCGCAGCTCTGTGCAGCGCACCCACTCGCTCCCGGTCCACTCGTCAC
CCCAGGCCATTCTCATGTTCCCTCCAGACTGCCCGGTTCCTGGGCCTGACCTGGAGATCAATCCCACTCTGGAGTCTCTGTGTCTGAGCA
TGACAGAACACGCCTTGGGTGATGGGACAGACAAAACCTCCACCATCTGACGGGACCCACAGCCCAGCGCACCCATAGGCTCCCTGGGCG
GCGGGCGGGGGCCAACCCCCAACGGGCTTCTCCGCGACAGCGAGAGGGTGGGCTGGCTCAGCTATATATTCTAATATTTTTCTACTCTCT
TACCCTCTTAACTTTTGTTTAACATTGGCACATGCCTTGCTCACTCCCAGGCCCGTCGAGGGATCTCTGCTGAGGCCCGGGGAGTTGGGG
GCAGCCAGGATAAAGGGGGCAGGGACTGGCCAGACTGCCTGCCTCTCTCCTTTCCTTCCTCATCCCCACCTGGTCCCATCCCACCCCTGC
CTCCTCCAGACCGCTGACCACCTGCCTCTCCCCAAGGGAGCAGACTCCCCAGAGACAAACTGACCACTACCTTGTGGAGCCTGCTCAGAA
ACATTTGACATTTGGGGTGACGCGCAGGGCAGAGAACCTGCCCTCCAGAATGTTATTGAGAGGAGCTGGGGAGAAGGAAGGGGAGCAAGG
AGAGGAAGCTCTCTCTCCTCTCCCTGCTTCCCCTTCACCATTCCCCACATTCTGCAAGGACAGGAGCCACCTTCCTCTCTCTCACCTCCC
CTGGCCCTGTTCACCAGAGGTTCTCTATGATTAATTTCTTAGGCCTATTTAAGATACATATTTATATAGTTCTTAACGGTTTTTCTCTGA
TCATTTCCTCTCATTTTTAGAATCCCCAGGTCTCTCTCAGCCAAGACAGTGGCAGGGAGAGCCTGAACTTTATGAGGGGAGAGGGCAGAG
CCCCCTCCTCCAGACCCTCAAGCTCTAACCCATTTTCCTCCAGCCCTGGCTACCCGGATGAAGAGGTTGGAGGTGGGCAGCCAGGGTAGC
CAGTGAGGTCAGGAAGTCTGTTGCCTTAACGTCCCCTTCCCCACGAACACACACCCTTCTCCGCTCCCAGGTCTGGTTGGTGAGACTTGG
GAGTCAGGAATAAGGGAAAGGGGATTGTTTGGTTTTTGGGTTTTTCCCTAAGCCCCTCCCTTTTCTTTCAGCCTTTTTCCTTCCCCCATT
ATGTCATGACCTCACTTAAGTGGAACACTATATCATAACCCAGAGATTCGTCCCAGCCCCAGAGTCCGACAGACTGTCTGGTCCCTATTC
CTAATGAGGGGTTGTGTTGGGGCCCAGGTGGAGGGAGGGGATTTGGGGGTTCAGACTGCGGGGAAGCCAGGGTCTCCCTCTTCAACGCCC
TCCTCCCCCTCAACCCACCTTCCCAACTGGGACATTCTCAAGCTTTTCACACCGAAAAGGAAAAAAAATGTTATTTTTAGATACATTTTA
TGAATAACTTTTGTTATGAATATGGCTGGTAACCATTGTGTATGTTATTAAAGATACAAAATGTTGGGAAAAAAACAAAAAAAACAAAAA

>66278_66278_9_PLEKHG5-SAMD4B_PLEKHG5_chr1_6556553_ENST00000537245_SAMD4B_chr19_39870606_ENST00000314471_length(amino acids)=234AA_BP=50
MSLGERGSPQTFGGSSVSKGSDAGHDQSPAEKKGLRCQNPACMDKGRAAKAFTETQKKRLLSWKQQVLKLLRTFPRKAALEMQNYRQQKG
WAFGSNSLPIAGSVGMGVARRTQRQFPMPPRALPPGRMGLLSPSGIGGVSPRHALTSPSLGGQGRQNLWFANPGGSNSMPSQSRSSVQRT

--------------------------------------------------------------
>66278_66278_10_PLEKHG5-SAMD4B_PLEKHG5_chr1_6556553_ENST00000537245_SAMD4B_chr19_39870606_ENST00000598913_length(transcript)=1222nt_BP=215nt
ACCGCGGTGCACTCCAGCCCCCAGGAAGAGAGGCAGCTTGGAGGGGGCCAAATTCAGGGTCAAAGATGAGTCTTGGGGAACGGGGGTCGC
CCCAGACCTTCGGGGGCTCCTCTGTCTCTAAAGGGAGCGATGCAGGGCACGACCAGAGCCCCGCTGAAAAGAAGGGACTGCGCTGTCAGA
ACCCCGCCTGCATGGACAAGGGGCGGGCGGCCAAGGCTTTCACGGAGACGCAGAAGAAACGGCTGCTATCCTGGAAACAGCAAGTGCTGA
AGCTCCTCCGGACATTCCCGCGCAAAGCCGCACTAGAGATGCAGAACTACCGGCAGCAGAAAGGCTGGGCATTCGGCTCCAACTCGCTCC
CCATAGCTGGCTCTGTGGGGATGGGAGTGGCCCGGCGTACCCAGCGGCAGTTCCCAATGCCTCCCCGGGCCCTCCCACCCGGCCGGATGG
GCCTCCTGAGCCCCTCGGGCATTGGGGGTGTCTCCCCTCGACATGCCCTCACCAGCCCCAGCCTTGGAGGCCAGGGCCGACAGAACCTGT
GGTTTGCCAACCCTGGAGGCAGCAACAGCATGCCCAGTCAGAGCCGCAGCTCTGTGCAGCGCACCCACTCGCTCCCGGTCCACTCGTCAC
CCCAGGCCATTCTCATGTTCCCTCCAGACTGCCCGGTTCCTGGGCCTGACCTGGAGATCAATCCCACTCTGGAGTCTCTGTGTCTGAGCA
TGACAGAACACGCCTTGGGTGGCCCGTCGAGGGATCTCTGCTGAGGCCCGGGGAGTTGGGGGCAGCCAGGATAAAGGGGGCAGGGACTGG
CCAGACTGCCTGCCTCTCTCCTTTCCTTCCTCATCCCCACCTGGTCCCATCCCACCCCTGCCTCCTCCAGACCGCTGACCACCTGCCTCT
CCCCAAGGGAGCAGACTCCCCAGAGACAAACTGACCACTACCTTGTGGAGCCTGCTCAGAAACATTTGACATTTGGGGTGACGCGCAGGG
CAGAGAACCTGCCCTCCAGAATGTTATTGAGAGGAGCTGGGGAGAAGGAAGGGGAGCAAGGAGAGGAAGCTCTCTCTCCTCTCCCTGCTT
CCCCTTCACCATTCCCCACATTCTGCAAGGACAGGAGCCACCTTCCTCTCTCTCACCTCCCCTGGCCCTGTTCACCAGAGGTTCTCTATG

>66278_66278_10_PLEKHG5-SAMD4B_PLEKHG5_chr1_6556553_ENST00000537245_SAMD4B_chr19_39870606_ENST00000598913_length(amino acids)=232AA_BP=50
MSLGERGSPQTFGGSSVSKGSDAGHDQSPAEKKGLRCQNPACMDKGRAAKAFTETQKKRLLSWKQQVLKLLRTFPRKAALEMQNYRQQKG
WAFGSNSLPIAGSVGMGVARRTQRQFPMPPRALPPGRMGLLSPSGIGGVSPRHALTSPSLGGQGRQNLWFANPGGSNSMPSQSRSSVQRT

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for PLEKHG5-SAMD4B

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for PLEKHG5-SAMD4B

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for PLEKHG5-SAMD4B

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source