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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PLEKHM2-IGF2BP2 (FusionGDB2 ID:66318)

Fusion Gene Summary for PLEKHM2-IGF2BP2

check button Fusion gene summary
Fusion gene informationFusion gene name: PLEKHM2-IGF2BP2
Fusion gene ID: 66318
HgeneTgene
Gene symbol

PLEKHM2

IGF2BP2

Gene ID

23207

10644

Gene namepleckstrin homology and RUN domain containing M2insulin like growth factor 2 mRNA binding protein 2
SynonymsSKIPIMP-2|IMP2|VICKZ2
Cytomap

1p36.21

3q27.2

Type of geneprotein-codingprotein-coding
Descriptionpleckstrin homology domain-containing family M member 2PH domain-containing family M member 2SifA (Salmonella-induced filaments A) and kinesin-interacting proteinnovel RUN and PH domain-containing proteinpleckstrin homology domain containing, family Minsulin-like growth factor 2 mRNA-binding protein 2IGF-II mRNA-binding protein 2IGF2 mRNA-binding protein 2VICKZ family member 2
Modification date2020031320200313
UniProtAcc.

Q9Y6M1

Ensembl transtripts involved in fusion geneENST00000375793, ENST00000375799, 
ENST00000477849, 		ENST00000494906, 
ENST00000346192, ENST00000382199, 
ENST00000421047, ENST00000457616, 
Fusion gene scores* DoF score9 X 7 X 6=3787 X 7 X 4=196
# samples 97
** MAII scorelog2(9/378*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/196*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PLEKHM2 [Title/Abstract] AND IGF2BP2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPLEKHM2(16046415)-IGF2BP2(185410550), # samples:5
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePLEKHM2

GO:1903527

positive regulation of membrane tubulation

18996344


check buttonFusion gene breakpoints across PLEKHM2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across IGF2BP2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-R6-A6Y2-01BPLEKHM2chr1

16046415

-IGF2BP2chr3

185410550

-
ChimerDB4ESCATCGA-R6-A6Y2-01BPLEKHM2chr1

16046415

+IGF2BP2chr3

185410550

-
ChimerDB4ESCATCGA-R6-A6Y2PLEKHM2chr1

16046415

+IGF2BP2chr3

185410550

-


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Fusion Gene ORF analysis for PLEKHM2-IGF2BP2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000375793ENST00000494906PLEKHM2chr1

16046415

+IGF2BP2chr3

185410550

-
5CDS-intronENST00000375799ENST00000494906PLEKHM2chr1

16046415

+IGF2BP2chr3

185410550

-
In-frameENST00000375793ENST00000346192PLEKHM2chr1

16046415

+IGF2BP2chr3

185410550

-
In-frameENST00000375793ENST00000382199PLEKHM2chr1

16046415

+IGF2BP2chr3

185410550

-
In-frameENST00000375793ENST00000421047PLEKHM2chr1

16046415

+IGF2BP2chr3

185410550

-
In-frameENST00000375793ENST00000457616PLEKHM2chr1

16046415

+IGF2BP2chr3

185410550

-
In-frameENST00000375799ENST00000346192PLEKHM2chr1

16046415

+IGF2BP2chr3

185410550

-
In-frameENST00000375799ENST00000382199PLEKHM2chr1

16046415

+IGF2BP2chr3

185410550

-
In-frameENST00000375799ENST00000421047PLEKHM2chr1

16046415

+IGF2BP2chr3

185410550

-
In-frameENST00000375799ENST00000457616PLEKHM2chr1

16046415

+IGF2BP2chr3

185410550

-
intron-3CDSENST00000477849ENST00000346192PLEKHM2chr1

16046415

+IGF2BP2chr3

185410550

-
intron-3CDSENST00000477849ENST00000382199PLEKHM2chr1

16046415

+IGF2BP2chr3

185410550

-
intron-3CDSENST00000477849ENST00000421047PLEKHM2chr1

16046415

+IGF2BP2chr3

185410550

-
intron-3CDSENST00000477849ENST00000457616PLEKHM2chr1

16046415

+IGF2BP2chr3

185410550

-
intron-intronENST00000477849ENST00000494906PLEKHM2chr1

16046415

+IGF2BP2chr3

185410550

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000375799PLEKHM2chr116046415+ENST00000382199IGF2BP2chr3185410550-41318791372338733
ENST00000375799PLEKHM2chr116046415+ENST00000421047IGF2BP2chr3185410550-40688791371081314
ENST00000375799PLEKHM2chr116046415+ENST00000457616IGF2BP2chr3185410550-38958791371081314
ENST00000375799PLEKHM2chr116046415+ENST00000346192IGF2BP2chr3185410550-37668791372209690
ENST00000375793PLEKHM2chr116046415+ENST00000382199IGF2BP2chr3185410550-4073821792280733
ENST00000375793PLEKHM2chr116046415+ENST00000421047IGF2BP2chr3185410550-4010821791023314
ENST00000375793PLEKHM2chr116046415+ENST00000457616IGF2BP2chr3185410550-3837821791023314
ENST00000375793PLEKHM2chr116046415+ENST00000346192IGF2BP2chr3185410550-3708821792151690

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000375799ENST00000382199PLEKHM2chr116046415+IGF2BP2chr3185410550-0.0029894340.9970106
ENST00000375799ENST00000421047PLEKHM2chr116046415+IGF2BP2chr3185410550-0.0035131320.9964869
ENST00000375799ENST00000457616PLEKHM2chr116046415+IGF2BP2chr3185410550-0.004447390.9955526
ENST00000375799ENST00000346192PLEKHM2chr116046415+IGF2BP2chr3185410550-0.0047409810.995259
ENST00000375793ENST00000382199PLEKHM2chr116046415+IGF2BP2chr3185410550-0.003128960.99687105
ENST00000375793ENST00000421047PLEKHM2chr116046415+IGF2BP2chr3185410550-0.003482560.9965174
ENST00000375793ENST00000457616PLEKHM2chr116046415+IGF2BP2chr3185410550-0.0043486950.9956513
ENST00000375793ENST00000346192PLEKHM2chr116046415+IGF2BP2chr3185410550-0.0048167530.9951833

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Fusion Genomic Features for PLEKHM2-IGF2BP2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PLEKHM2-IGF2BP2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:16046415/chr3:185410550)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.IGF2BP2

Q9Y6M1

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (By similarity). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific. Binds to beta-actin/ACTB and MYC transcripts. {ECO:0000250, ECO:0000269|PubMed:23640942, ECO:0000269|PubMed:9891060}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePLEKHM2chr1:16046415chr3:185410550ENST00000375799+62036_1582171020.0DomainRUN
TgeneIGF2BP2chr1:16046415chr3:185410550ENST00000346192315193_258113557.0DomainKH 1
TgeneIGF2BP2chr1:16046415chr3:185410550ENST00000346192315274_341113557.0DomainKH 2
TgeneIGF2BP2chr1:16046415chr3:185410550ENST00000346192315427_492113557.0DomainKH 3
TgeneIGF2BP2chr1:16046415chr3:185410550ENST00000346192315509_575113557.0DomainKH 4
TgeneIGF2BP2chr1:16046415chr3:185410550ENST00000382199316193_258113600.0DomainKH 1
TgeneIGF2BP2chr1:16046415chr3:185410550ENST00000382199316274_341113600.0DomainKH 2
TgeneIGF2BP2chr1:16046415chr3:185410550ENST00000382199316427_492113600.0DomainKH 3
TgeneIGF2BP2chr1:16046415chr3:185410550ENST00000382199316509_575113600.0DomainKH 4
TgeneIGF2BP2chr1:16046415chr3:185410550ENST00000421047015193_2580543.0DomainKH 1
TgeneIGF2BP2chr1:16046415chr3:185410550ENST00000421047015274_3410543.0DomainKH 2
TgeneIGF2BP2chr1:16046415chr3:185410550ENST000004210470153_760543.0DomainRRM 1
TgeneIGF2BP2chr1:16046415chr3:185410550ENST00000421047015427_4920543.0DomainKH 3
TgeneIGF2BP2chr1:16046415chr3:185410550ENST00000421047015509_5750543.0DomainKH 4
TgeneIGF2BP2chr1:16046415chr3:185410550ENST0000042104701582_1570543.0DomainRRM 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePLEKHM2chr1:16046415chr3:185410550ENST00000375799+620317_3202171020.0Compositional biasNote=Poly-Lys
HgenePLEKHM2chr1:16046415chr3:185410550ENST00000375799+620323_3262171020.0Compositional biasNote=Poly-Lys
HgenePLEKHM2chr1:16046415chr3:185410550ENST00000375799+620506_5112171020.0Compositional biasNote=Poly-Gly
HgenePLEKHM2chr1:16046415chr3:185410550ENST00000375799+620593_5962171020.0Compositional biasNote=Poly-Leu
HgenePLEKHM2chr1:16046415chr3:185410550ENST00000375799+620771_8732171020.0DomainPH
TgeneIGF2BP2chr1:16046415chr3:185410550ENST000003461923153_76113557.0DomainRRM 1
TgeneIGF2BP2chr1:16046415chr3:185410550ENST0000034619231582_157113557.0DomainRRM 2
TgeneIGF2BP2chr1:16046415chr3:185410550ENST000003821993163_76113600.0DomainRRM 1
TgeneIGF2BP2chr1:16046415chr3:185410550ENST0000038219931682_157113600.0DomainRRM 2


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Fusion Gene Sequence for PLEKHM2-IGF2BP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>66318_66318_1_PLEKHM2-IGF2BP2_PLEKHM2_chr1_16046415_ENST00000375793_IGF2BP2_chr3_185410550_ENST00000346192_length(transcript)=3708nt_BP=821nt
AGGCGAGGCGAGGGCCGGGCGGCGGGCGCCGGGCCCCGCGGCCGGCACGACGGAGCCCCCGTACGGCCGGCGGCAGCGGTTGGCGGCGGC
CCCCGGCCCCCGGCGCGGGAAGCGGCGGCGGGGCGGCGGCGGCGGTGGCGGTGGCGGTGGCGGCGACGGTGGCAGCGCCATGGAGCCGGG
GGAGGTGAAGGACCGGATCCTGGAGAACATCTCGCTGTCGGTGAAGAAGTTGCAGAGCTATTTTGCTGCATGTGAGGATGAGATCCCTGC
CATCCGGAACCATGACAAGGTCCTACAGCGTCTGTGTGAGCACCTGGACCACGCCCTGCTGTACGGACTGCAAGACCTCTCCTCTGGCTA
CTGGGTGCTCGTGGTGCATTTTACTCGGAGAGAGGCCATCAAGCAGATCGAGGTGCTGCAGCACGTGGCCACCAACCTGGGGCGCAGCCG
TGCCTGGCTGTACCTGGCCCTCAACGAGAACTCCTTGGAGAGCTACCTGCGGTTGTTCCAGGAGAACCTGGGCCTGCTGCATAAGTACTA
CGTCAAGAATGCCCTGGTCTGCAGCCACGATCACCTGACGCTCTTCCTGACCTTGGTGTCCGGGCTAGAGTTCATTCGTTTCGAGCTGGA
TCTGGATGCCCCTTACCTAGACCTGGCCCCCTACATGCCCGACTACTACAAACCTCAGTACCTGCTGGACTTTGAAGACCGCCTTCCCAG
CTCGGTCCACGGCTCAGACAGTCTGTCCCTCAACTCTTTCAACTCCGTCACCTCCACCAACCTGGAGTGGGATGACAGTGCGATTGCCCC
ATCTAGTGAGGTCAACACAGACACAGAAACCGCCGTTGTCAACGTCACATATGCAACAAGAGAAGAAGCAAAAATAGCCATGGAGAAGCT
AAGCGGGCATCAGTTTGAGAACTACTCCTTCAAGATTTCCTACATCCCGGATGAAGAGGTGAGCTCCCCTTCGCCCCCTCAGCGAGCCCA
GCGTGGGGACCACTCTTCCCGGGAGCAAGGCCACGCCCCTGGGGGCACTTCTCAGGCCAGACAGATTGATTTCCCGCTGCGGATCCTGGT
CCCCACCCAGTTTGTTGGTGCCATCATCGGAAAGGAGGGCTTGACCATAAAGAACATCACTAAGCAGACCCAGTCCCGGGTAGATATCCA
TAGAAAAGAGAACTCTGGAGCTGCAGAGAAGCCTGTCACCATCCATGCCACCCCAGAGGGGACTTCTGAAGCATGCCGCATGATTCTTGA
AATCATGCAGAAAGAGGCAGATGAGACCAAACTAGCCGAAGAGATTCCTCTGAAAATCTTGGCACACAATGGCTTGGTTGGAAGACTGAT
TGGAAAAGAAGGCAGAAATTTGAAGAAAATTGAACATGAAACAGGGACCAAGATAACAATCTCATCTTTGCAGGATTTGAGCATATACAA
CCCGGAAAGAACCATCACTGTGAAGGGCACAGTTGAGGCCTGTGCCAGTGCTGAGATAGAGATTATGAAGAAGCTGCGTGAGGCCTTTGA
AAATGATATGCTGGCTGTTAACACCCACTCCGGATACTTCTCCAGCCTGTACCCCCATCACCAGTTTGGCCCGTTCCCGCATCATCACTC
TTATCCAGAGCAGGAGATTGTGAATCTCTTCATCCCAACCCAGGCTGTGGGCGCCATCATCGGGAAGAAGGGGGCACACATCAAACAGCT
GGCGAGATTCGCCGGAGCCTCTATCAAGATTGCCCCTGCGGAAGGCCCAGACGTCAGCGAAAGGATGGTCATCATCACCGGGCCACCGGA
AGCCCAGTTCAAGGCCCAGGGACGGATCTTTGGGAAACTGAAAGAGGAAAACTTCTTTAACCCCAAAGAAGAAGTGAAGCTGGAAGCGCA
TATCAGAGTGCCCTCTTCCACAGCTGGCCGGGTGATTGGCAAAGGTGGCAAGACCGTGAACGAACTGCAGAACTTAACCAGTGCAGAAGT
CATCGTGCCTCGTGACCAAACGCCAGATGAAAATGAGGAAGTGATCGTCAGAATTATCGGGCACTTCTTTGCTAGCCAGACTGCACAGCG
CAAGATCAGGGAAATTGTACAACAGGTGAAGCAGCAGGAGCAGAAATACCCTCAGGGAGTCGCCTCACAGCGCAGCAAGTGAGGCTCCCA
CAGGCACCAGCAAAACAACGGATGAATGTAGCCCTTCCAACACCTGACAGAATGAGACCAAACGCAGCCAGCCAGATCGGGAGCAAACCA
AAGACCATCTGAGGAATGAGAAGTCTGCGGAGGCGGCCAGGGACTCTGCCGAGGCCCTGAGAACCCCAGGGGCCGAGGAGGGGCGGGGAA
GGTCAGCCAGGTTTGCCAGAACCACCGAGCCCCGCCTCCCGCCCCCCAGGGCTTCTGCAGGCTTCAGCCATCCACTTCACCATCCACTCG
GATCTCTCCTGAACTCCCACGACGCTATCCCTTTTAGTTGAACTAACATAGGTGAACGTGTTCAAAGCCAAGCAAAATGCACACCCTTTT
TCTGTGGCAAATCGTCTCTGTACATGTGTGTACATATTAGAAAGGGAAGATGTTAAGATATGTGGCCTGTGGGTTACACAGGGTGCCTGC
AGCGGTAATATATTTTAGAAATAATATATCAAATAACTCAACTAACTCCAATTTTTAATCAATTATTAATTTTTTTTTCTTTTTAAAGAG
AAAGCAGGCTTTTCTAGACTTTAAAGAATAAAGTCTTTGGGAGGTCTCACGGTGTAGAGAGGAGCTTTGAGGCCACCCGCACAAAATTCA
CCCAGAGGGAAATCTCGTCGGAAGGACACTCACGGCAGTTCTGGATCACCTGTGTATGTCAACAGAAGGGATACCGTCTCCTTGAAGAGG
AAACTCTGTCACTCCTCATGCCTGTCTAGCTCATACACCCATTTCTCTTTGCTTCACAGGTTTTAAACTGGTTTTTTGCATACTGCTATA
TAATTCTCTGTCTCTCTCTGTTTATCTCTCCCCTCCCTCCCCTCCCCTTCTTCTCCATCTCCATTCTTTTGAATTTCCTCATCCCTCCAT
CTCAATCCCGTATCTACGCACCCCCCCCCCCCCAGGCAAAGCAGTGCTCTGAGTATCACATCACACAAAAGGAACAAAAGCGAAACACAC
AAACCAGCCTCAACTTACACTTGGTTACTCAAAAGAACAAGAGTCAATGGTACTTGTCCTAGCGTTTTGGAAGAGGAAAACAGGAACCCA
CCAAACCAACCAATCAACCAAACAAAGAAAAAATTCCACAATGAAAGAATGTATTTTGTCTTTTTGCATTTTGGTGTATAAGCCATCAAT
ATTCAGCAAAATGATTCCTTTCTTTAAAAAAAAAAAATGTGGAGGAAAGTAGAAATTTACCAAGGTTGTTGGCCCAGGGCGTTAAATTCA
CAGATTTTTTTAACGAGAAAAACACACAGAAGAAGCTACCTCAGGTGTTTTTACCTCAGCACCTTGCTCTTGTGTTTCCCTTAGAGATTT
TGTAAAGCTGATAGTTGGAGCATTTTTTTATTTTTTTAATAAAAATGAGTTGGAAAAAAAATAAGATATCAACTGCCAGCCTGGAGAAGG
TGACAGTCCAAGTGTGCAACAGCTGTTCTGAATTGTCTTCCGCTAGCCAAGAACCTATATGGCCTTCTTTTGGACAAACCTTGAAAATGT

>66318_66318_1_PLEKHM2-IGF2BP2_PLEKHM2_chr1_16046415_ENST00000375793_IGF2BP2_chr3_185410550_ENST00000346192_length(amino acids)=690AA_BP=245
MAAAPGPRRGKRRRGGGGGGGGGGGDGGSAMEPGEVKDRILENISLSVKKLQSYFAACEDEIPAIRNHDKVLQRLCEHLDHALLYGLQDL
SSGYWVLVVHFTRREAIKQIEVLQHVATNLGRSRAWLYLALNENSLESYLRLFQENLGLLHKYYVKNALVCSHDHLTLFLTLVSGLEFIR
FELDLDAPYLDLAPYMPDYYKPQYLLDFEDRLPSSVHGSDSLSLNSFNSVTSTNLEWDDSAIAPSSEVNTDTETAVVNVTYATREEAKIA
MEKLSGHQFENYSFKISYIPDEEVSSPSPPQRAQRGDHSSREQGHAPGGTSQARQIDFPLRILVPTQFVGAIIGKEGLTIKNITKQTQSR
VDIHRKENSGAAEKPVTIHATPEGTSEACRMILEIMQKEADETKLAEEIPLKILAHNGLVGRLIGKEGRNLKKIEHETGTKITISSLQDL
SIYNPERTITVKGTVEACASAEIEIMKKLREAFENDMLAVNTHSGYFSSLYPHHQFGPFPHHHSYPEQEIVNLFIPTQAVGAIIGKKGAH
IKQLARFAGASIKIAPAEGPDVSERMVIITGPPEAQFKAQGRIFGKLKEENFFNPKEEVKLEAHIRVPSSTAGRVIGKGGKTVNELQNLT

--------------------------------------------------------------
>66318_66318_2_PLEKHM2-IGF2BP2_PLEKHM2_chr1_16046415_ENST00000375793_IGF2BP2_chr3_185410550_ENST00000382199_length(transcript)=4073nt_BP=821nt
AGGCGAGGCGAGGGCCGGGCGGCGGGCGCCGGGCCCCGCGGCCGGCACGACGGAGCCCCCGTACGGCCGGCGGCAGCGGTTGGCGGCGGC
CCCCGGCCCCCGGCGCGGGAAGCGGCGGCGGGGCGGCGGCGGCGGTGGCGGTGGCGGTGGCGGCGACGGTGGCAGCGCCATGGAGCCGGG
GGAGGTGAAGGACCGGATCCTGGAGAACATCTCGCTGTCGGTGAAGAAGTTGCAGAGCTATTTTGCTGCATGTGAGGATGAGATCCCTGC
CATCCGGAACCATGACAAGGTCCTACAGCGTCTGTGTGAGCACCTGGACCACGCCCTGCTGTACGGACTGCAAGACCTCTCCTCTGGCTA
CTGGGTGCTCGTGGTGCATTTTACTCGGAGAGAGGCCATCAAGCAGATCGAGGTGCTGCAGCACGTGGCCACCAACCTGGGGCGCAGCCG
TGCCTGGCTGTACCTGGCCCTCAACGAGAACTCCTTGGAGAGCTACCTGCGGTTGTTCCAGGAGAACCTGGGCCTGCTGCATAAGTACTA
CGTCAAGAATGCCCTGGTCTGCAGCCACGATCACCTGACGCTCTTCCTGACCTTGGTGTCCGGGCTAGAGTTCATTCGTTTCGAGCTGGA
TCTGGATGCCCCTTACCTAGACCTGGCCCCCTACATGCCCGACTACTACAAACCTCAGTACCTGCTGGACTTTGAAGACCGCCTTCCCAG
CTCGGTCCACGGCTCAGACAGTCTGTCCCTCAACTCTTTCAACTCCGTCACCTCCACCAACCTGGAGTGGGATGACAGTGCGATTGCCCC
ATCTAGTGAGGTCAACACAGACACAGAAACCGCCGTTGTCAACGTCACATATGCAACAAGAGAAGAAGCAAAAATAGCCATGGAGAAGCT
AAGCGGGCATCAGTTTGAGAACTACTCCTTCAAGATTTCCTACATCCCGGATGAAGAGGTGAGCTCCCCTTCGCCCCCTCAGCGAGCCCA
GCGTGGGGACCACTCTTCCCGGGAGCAAGGCCACGCCCCTGGGGGCACTTCTCAGGCCAGACAGATTGATTTCCCGCTGCGGATCCTGGT
CCCCACCCAGTTTGTTGGTGCCATCATCGGAAAGGAGGGCTTGACCATAAAGAACATCACTAAGCAGACCCAGTCCCGGGTAGATATCCA
TAGAAAAGAGAACTCTGGAGCTGCAGAGAAGCCTGTCACCATCCATGCCACCCCAGAGGGGACTTCTGAAGCATGCCGCATGATTCTTGA
AATCATGCAGAAAGAGGCAGATGAGACCAAACTAGCCGAAGAGATTCCTCTGAAAATCTTGGCACACAATGGCTTGGTTGGAAGACTGAT
TGGAAAAGAAGGCAGAAATTTGAAGAAAATTGAACATGAAACAGGGACCAAGATAACAATCTCATCTTTGCAGGATTTGAGCATATACAA
CCCGGAAAGAACCATCACTGTGAAGGGCACAGTTGAGGCCTGTGCCAGTGCTGAGATAGAGATTATGAAGAAGCTGCGTGAGGCCTTTGA
AAATGATATGCTGGCTGTTAACCAACAAGCCAATCTGATCCCAGGGTTGAACCTCAGCGCACTTGGCATCTTTTCAACAGGACTGTCCGT
GCTATCTCCACCAGCAGGGCCCCGCGGAGCTCCCCCCGCTGCCCCCTACCACCCCTTCACTACCCACTCCGGATACTTCTCCAGCCTGTA
CCCCCATCACCAGTTTGGCCCGTTCCCGCATCATCACTCTTATCCAGAGCAGGAGATTGTGAATCTCTTCATCCCAACCCAGGCTGTGGG
CGCCATCATCGGGAAGAAGGGGGCACACATCAAACAGCTGGCGAGATTCGCCGGAGCCTCTATCAAGATTGCCCCTGCGGAAGGCCCAGA
CGTCAGCGAAAGGATGGTCATCATCACCGGGCCACCGGAAGCCCAGTTCAAGGCCCAGGGACGGATCTTTGGGAAACTGAAAGAGGAAAA
CTTCTTTAACCCCAAAGAAGAAGTGAAGCTGGAAGCGCATATCAGAGTGCCCTCTTCCACAGCTGGCCGGGTGATTGGCAAAGGTGGCAA
GACCGTGAACGAACTGCAGAACTTAACCAGTGCAGAAGTCATCGTGCCTCGTGACCAAACGCCAGATGAAAATGAGGAAGTGATCGTCAG
AATTATCGGGCACTTCTTTGCTAGCCAGACTGCACAGCGCAAGATCAGGGAAATTGTACAACAGGTGAAGCAGCAGGAGCAGAAATACCC
TCAGGGAGTCGCCTCACAGCGCAGCAAGTGAGGCTCCCACAGGCACCAGCAAAACAACGGATGAATGTAGCCCTTCCAACACCTGACAGA
ATGAGACCAAACGCAGCCAGCCAGATCGGGAGCAAACCAAAGACCATCTGAGGAATGAGAAGTCTGCGGAGGCGGCCAGGGACTCTGCCG
AGGCCCTGAGAACCCCAGGGGCCGAGGAGGGGCGGGGAAGGTCAGCCAGGTTTGCCAGAACCACCGAGCCCCGCCTCCCGCCCCCCAGGG
CTTCTGCAGGCTTCAGCCATCCACTTCACCATCCACTCGGATCTCTCCTGAACTCCCACGACGCTATCCCTTTTAGTTGAACTAACATAG
GTGAACGTGTTCAAAGCCAAGCAAAATGCACACCCTTTTTCTGTGGCAAATCGTCTCTGTACATGTGTGTACATATTAGAAAGGGAAGAT
GTTAAGATATGTGGCCTGTGGGTTACACAGGGTGCCTGCAGCGGTAATATATTTTAGAAATAATATATCAAATAACTCAACTAACTCCAA
TTTTTAATCAATTATTAATTTTTTTTTCTTTTTAAAGAGAAAGCAGGCTTTTCTAGACTTTAAAGAATAAAGTCTTTGGGAGGTCTCACG
GTGTAGAGAGGAGCTTTGAGGCCACCCGCACAAAATTCACCCAGAGGGAAATCTCGTCGGAAGGACACTCACGGCAGTTCTGGATCACCT
GTGTATGTCAACAGAAGGGATACCGTCTCCTTGAAGAGGAAACTCTGTCACTCCTCATGCCTGTCTAGCTCATACACCCATTTCTCTTTG
CTTCACAGGTTTTAAACTGGTTTTTTGCATACTGCTATATAATTCTCTGTCTCTCTCTGTTTATCTCTCCCCTCCCTCCCCTCCCCTTCT
TCTCCATCTCCATTCTTTTGAATTTCCTCATCCCTCCATCTCAATCCCGTATCTACGCACCCCCCCCCCCCCAGGCAAAGCAGTGCTCTG
AGTATCACATCACACAAAAGGAACAAAAGCGAAACACACAAACCAGCCTCAACTTACACTTGGTTACTCAAAAGAACAAGAGTCAATGGT
ACTTGTCCTAGCGTTTTGGAAGAGGAAAACAGGAACCCACCAAACCAACCAATCAACCAAACAAAGAAAAAATTCCACAATGAAAGAATG
TATTTTGTCTTTTTGCATTTTGGTGTATAAGCCATCAATATTCAGCAAAATGATTCCTTTCTTTAAAAAAAAAAAATGTGGAGGAAAGTA
GAAATTTACCAAGGTTGTTGGCCCAGGGCGTTAAATTCACAGATTTTTTTAACGAGAAAAACACACAGAAGAAGCTACCTCAGGTGTTTT
TACCTCAGCACCTTGCTCTTGTGTTTCCCTTAGAGATTTTGTAAAGCTGATAGTTGGAGCATTTTTTTATTTTTTTAATAAAAATGAGTT
GGAAAAAAAATAAGATATCAACTGCCAGCCTGGAGAAGGTGACAGTCCAAGTGTGCAACAGCTGTTCTGAATTGTCTTCCGCTAGCCAAG
AACCTATATGGCCTTCTTTTGGACAAACCTTGAAAATGTTTATTTAAAAAAAAAAAAGATGACAAAGAAAAACAGAGAGAGAGAATATTG
GAGATGTCCTGAATTTTAATAGGGTACGCGCCATTAGGGCTTTTTGCGCTAAAGGATGAACATGTACTGGTTTATGTGGACAAGCCATTA
TACCACCAGACTGCAATGCCAGTTTCCTCTACTGCAAACAGTGTTCTGTGACAAAAAAAAAAAAAAAAAAAAGAAAAAAAAAGAAAAAAC

>66318_66318_2_PLEKHM2-IGF2BP2_PLEKHM2_chr1_16046415_ENST00000375793_IGF2BP2_chr3_185410550_ENST00000382199_length(amino acids)=733AA_BP=245
MAAAPGPRRGKRRRGGGGGGGGGGGDGGSAMEPGEVKDRILENISLSVKKLQSYFAACEDEIPAIRNHDKVLQRLCEHLDHALLYGLQDL
SSGYWVLVVHFTRREAIKQIEVLQHVATNLGRSRAWLYLALNENSLESYLRLFQENLGLLHKYYVKNALVCSHDHLTLFLTLVSGLEFIR
FELDLDAPYLDLAPYMPDYYKPQYLLDFEDRLPSSVHGSDSLSLNSFNSVTSTNLEWDDSAIAPSSEVNTDTETAVVNVTYATREEAKIA
MEKLSGHQFENYSFKISYIPDEEVSSPSPPQRAQRGDHSSREQGHAPGGTSQARQIDFPLRILVPTQFVGAIIGKEGLTIKNITKQTQSR
VDIHRKENSGAAEKPVTIHATPEGTSEACRMILEIMQKEADETKLAEEIPLKILAHNGLVGRLIGKEGRNLKKIEHETGTKITISSLQDL
SIYNPERTITVKGTVEACASAEIEIMKKLREAFENDMLAVNQQANLIPGLNLSALGIFSTGLSVLSPPAGPRGAPPAAPYHPFTTHSGYF
SSLYPHHQFGPFPHHHSYPEQEIVNLFIPTQAVGAIIGKKGAHIKQLARFAGASIKIAPAEGPDVSERMVIITGPPEAQFKAQGRIFGKL
KEENFFNPKEEVKLEAHIRVPSSTAGRVIGKGGKTVNELQNLTSAEVIVPRDQTPDENEEVIVRIIGHFFASQTAQRKIREIVQQVKQQE

--------------------------------------------------------------
>66318_66318_3_PLEKHM2-IGF2BP2_PLEKHM2_chr1_16046415_ENST00000375793_IGF2BP2_chr3_185410550_ENST00000421047_length(transcript)=4010nt_BP=821nt
AGGCGAGGCGAGGGCCGGGCGGCGGGCGCCGGGCCCCGCGGCCGGCACGACGGAGCCCCCGTACGGCCGGCGGCAGCGGTTGGCGGCGGC
CCCCGGCCCCCGGCGCGGGAAGCGGCGGCGGGGCGGCGGCGGCGGTGGCGGTGGCGGTGGCGGCGACGGTGGCAGCGCCATGGAGCCGGG
GGAGGTGAAGGACCGGATCCTGGAGAACATCTCGCTGTCGGTGAAGAAGTTGCAGAGCTATTTTGCTGCATGTGAGGATGAGATCCCTGC
CATCCGGAACCATGACAAGGTCCTACAGCGTCTGTGTGAGCACCTGGACCACGCCCTGCTGTACGGACTGCAAGACCTCTCCTCTGGCTA
CTGGGTGCTCGTGGTGCATTTTACTCGGAGAGAGGCCATCAAGCAGATCGAGGTGCTGCAGCACGTGGCCACCAACCTGGGGCGCAGCCG
TGCCTGGCTGTACCTGGCCCTCAACGAGAACTCCTTGGAGAGCTACCTGCGGTTGTTCCAGGAGAACCTGGGCCTGCTGCATAAGTACTA
CGTCAAGAATGCCCTGGTCTGCAGCCACGATCACCTGACGCTCTTCCTGACCTTGGTGTCCGGGCTAGAGTTCATTCGTTTCGAGCTGGA
TCTGGATGCCCCTTACCTAGACCTGGCCCCCTACATGCCCGACTACTACAAACCTCAGTACCTGCTGGACTTTGAAGACCGCCTTCCCAG
CTCGGTCCACGGCTCAGACAGTCTGTCCCTCAACTCTTTCAACTCCGTCACCTCCACCAACCTGGAGTGGGATGACAGTGCGATTGCCCC
ATCTAGTGAGGACTGCACAGCGCAAGATCAGGGAAATTGTACAACAGGTGAAGCAGCAGGAGCAGAAATACCCTCAGGGAGTCGCCTCAC
AGCGCAGCAAGTGAGGCTCCCACAGGCACCAGCAAAACAACGGATGAATGTAGCCCTTCCAACACCTGACAGAATGAGACCAAACGCAGC
CAGCCAGATCGGGAGCAAACCAAAGACCATCTGAGGAATGAGAAGTCTGCGGAGGCGGCCAGGGACTCTGCCGAGGCCCTGAGAACCCCA
GGGGCCGAGGAGGGGCGGGGAAGGTCAGCCAGGTTTGCCAGAACCACCGAGCCCCGCCTCCCGCCCCCCAGGGCTTCTGCAGGCTTCAGC
CATCCACTTCACCATCCACTCGGATCTCTCCTGAACTCCCACGACGCTATCCCTTTTAGTTGAACTAACATAGGTGAACGTGTTCAAAGC
CAAGCAAAATGCACACCCTTTTTCTGTGGCAAATCGTCTCTGTACATGTGTGTACATATTAGAAAGGGAAGATGTTAAGATATGTGGCCT
GTGGGTTACACAGGGTGCCTGCAGCGGTAATATATTTTAGAAATAATATATCAAATAACTCAACTAACTCCAATTTTTAATCAATTATTA
ATTTTTTTTTCTTTTTAAAGAGAAAGCAGGCTTTTCTAGACTTTAAAGAATAAAGTCTTTGGGAGGTCTCACGGTGTAGAGAGGAGCTTT
GAGGCCACCCGCACAAAATTCACCCAGAGGGAAATCTCGTCGGAAGGACACTCACGGCAGTTCTGGATCACCTGTGTATGTCAACAGAAG
GGATACCGTCTCCTTGAAGAGGAAACTCTGTCACTCCTCATGCCTGTCTAGCTCATACACCCATTTCTCTTTGCTTCACAGGTTTTAAAC
TGGTTTTTTGCATACTGCTATATAATTCTCTGTCTCTCTCTGTTTATCTCTCCCCTCCCTCCCCTCCCCTTCTTCTCCATCTCCATTCTT
TTGAATTTCCTCATCCCTCCATCTCAATCCCGTATCTACGCACCCCCCCCCCCCCAGGCAAAGCAGTGCTCTGAGTATCACATCACACAA
AAGGAACAAAAGCGAAACACACAAACCAGCCTCAACTTACACTTGGTTACTCAAAAGAACAAGAGTCAATGGTACTTGTCCTAGCGTTTT
GGAAGAGGAAAACAGGAACCCACCAAACCAACCAATCAACCAAACAAAGAAAAAATTCCACAATGAAAGAATGTATTTTGTCTTTTTGCA
TTTTGGTGTATAAGCCATCAATATTCAGCAAAATGATTCCTTTCTTTAAAAAAAAAAAATGTGGAGGAAAGTAGAAATTTACCAAGGTTG
TTGGCCCAGGGCGTTAAATTCACAGATTTTTTTAACGAGAAAAACACACAGAAGAAGCTACCTCAGGTGTTTTTACCTCAGCACCTTGCT
CTTGTGTTTCCCTTAGAGATTTTGTAAAGCTGATAGTTGGAGCATTTTTTTATTTTTTTAATAAAAATGAGTTGGAAAAAAAATAAGATA
TCAACTGCCAGCCTGGAGAAGGTGACAGTCCAAGTGTGCAACAGCTGTTCTGAATTGTCTTCCGCTAGCCAAGAACCTATATGGCCTTCT
TTTGGACAAACCTTGAAAATGTTTATTTAAAAAAAAAAAAGATGACAAAGAAAAACAGAGAGAGAGAATATTGGAGATGTCCTGAATTTT
AATAGGGTACGCGCCATTAGGGCTTTTTGCGCTAAAGGATGAACATGTACTGGTTTATGTGGACAAGCCATTATACCACCAGACTGCAAT
GCCAGTTTCCTCTACTGCAAACAGTGTTCTGTGGTGAACGAACTGCAGAACTTAACCAGTGCAGAAGTCATCGTGCCTCGTGACCAAACG
CCAGATGAAAATGAGGAAGTGATCGTCAGAATTATCGGGCACTTCTTTGCTAGCCAGGCCCAGGGACGGATCTTTGGGAAACTGAAAGAG
GAAAACTTCTTTAACCCCAAAGAAGAAGTGAAGCTGGAAGCGCATATCAGAGTGCCCTCTTCCACAGCTGGCCGGGTGATTGGCAAAGGT
GGCAAGACCATTGCCCCTGCGGAAGGCCCAGACGTCAGCGAAAGGATGGTCATCATCACCGGGCCACCGGAAGCCCAGTTCAAGTATCCA
GAGCAGGAGATTGTGAATCTCTTCATCCCAACCCAGGCTGTGGGCGCCATCATCGGGAAGAAGGGGGCACACATCAAACAGCTGGCGAGA
TTCGCCGGAGCCTCTATCAAGACCCACTCCGGATACTTCTCCAGCCTGTACCCCCATCACCAGTTTGGCCCGTTCCCGCATCATCACTCT
CAACAAGCCAATCTGATCCCAGGGTTGAACCTCAGCGCACTTGGCATCTTTTCAACAGGACTGTCCGTGCTATCTCCACCAGCAGGGCCC
CGCGGAGCTCCCCCCGCTGCCCCCTACCACCCCTTCACTTTTGCAGGATTTGAGCATATACAACCCGGAAAGAACCATCACTGTGAAGGG
CACAGTTGAGGCCTGTGCCAGTGCTGAGATAGAGATTATGAAGAAGCTGCGTGAGGCCTTTGAAAATGATATGCTGGCTGTTAACAGCCG
AAGAGATTCCTCTGAAAATCTTGGCACACAATGGCTTGGTTGGAAGACTGATTGGAAAAGAAGGCAGAAATTTGAAGAAAATTGAACATG
AAACAGGGACCAAGATAACAATCTCATCGGTAGATATCCATAGAAAAGAGAACTCTGGAGCTGCAGAGAAGCCTGTCACCATCCATGCCA
CCCCAGAGGGGACTTCTGAAGCATGCCGCATGATTCTTGAAATCATGCAGAAAGAGGCAGATGAGACCAAACTAGCCATGGAGAAGCTAA
GCGGGCATCAGTTTGAGAACTACTCCTTCAAGATTTCCTACATCCCGGATGAAGAGGTGAGCTCCCCTTCGCCCCCTCAGCGAGCCCAGC
GTGGGGACCACTCTTCCCGGGAGCAAGGCCACGCCCCTGGGGGCACTTCTCAGGCCAGACAGATTGATTTCCCGCTGCGGATCCTGGTCC
CCACCCAGTTTGTTGGTGCCATCATCGGAAAGGAGGGCTTGACCATAAAGAACATCACTAAGCAGACCCAGTCCCGTCAACACAGACACA

>66318_66318_3_PLEKHM2-IGF2BP2_PLEKHM2_chr1_16046415_ENST00000375793_IGF2BP2_chr3_185410550_ENST00000421047_length(amino acids)=314AA_BP=
MAAAPGPRRGKRRRGGGGGGGGGGGDGGSAMEPGEVKDRILENISLSVKKLQSYFAACEDEIPAIRNHDKVLQRLCEHLDHALLYGLQDL
SSGYWVLVVHFTRREAIKQIEVLQHVATNLGRSRAWLYLALNENSLESYLRLFQENLGLLHKYYVKNALVCSHDHLTLFLTLVSGLEFIR
FELDLDAPYLDLAPYMPDYYKPQYLLDFEDRLPSSVHGSDSLSLNSFNSVTSTNLEWDDSAIAPSSEDCTAQDQGNCTTGEAAGAEIPSG

--------------------------------------------------------------
>66318_66318_4_PLEKHM2-IGF2BP2_PLEKHM2_chr1_16046415_ENST00000375793_IGF2BP2_chr3_185410550_ENST00000457616_length(transcript)=3837nt_BP=821nt
AGGCGAGGCGAGGGCCGGGCGGCGGGCGCCGGGCCCCGCGGCCGGCACGACGGAGCCCCCGTACGGCCGGCGGCAGCGGTTGGCGGCGGC
CCCCGGCCCCCGGCGCGGGAAGCGGCGGCGGGGCGGCGGCGGCGGTGGCGGTGGCGGTGGCGGCGACGGTGGCAGCGCCATGGAGCCGGG
GGAGGTGAAGGACCGGATCCTGGAGAACATCTCGCTGTCGGTGAAGAAGTTGCAGAGCTATTTTGCTGCATGTGAGGATGAGATCCCTGC
CATCCGGAACCATGACAAGGTCCTACAGCGTCTGTGTGAGCACCTGGACCACGCCCTGCTGTACGGACTGCAAGACCTCTCCTCTGGCTA
CTGGGTGCTCGTGGTGCATTTTACTCGGAGAGAGGCCATCAAGCAGATCGAGGTGCTGCAGCACGTGGCCACCAACCTGGGGCGCAGCCG
TGCCTGGCTGTACCTGGCCCTCAACGAGAACTCCTTGGAGAGCTACCTGCGGTTGTTCCAGGAGAACCTGGGCCTGCTGCATAAGTACTA
CGTCAAGAATGCCCTGGTCTGCAGCCACGATCACCTGACGCTCTTCCTGACCTTGGTGTCCGGGCTAGAGTTCATTCGTTTCGAGCTGGA
TCTGGATGCCCCTTACCTAGACCTGGCCCCCTACATGCCCGACTACTACAAACCTCAGTACCTGCTGGACTTTGAAGACCGCCTTCCCAG
CTCGGTCCACGGCTCAGACAGTCTGTCCCTCAACTCTTTCAACTCCGTCACCTCCACCAACCTGGAGTGGGATGACAGTGCGATTGCCCC
ATCTAGTGAGGACTGCACAGCGCAAGATCAGGGAAATTGTACAACAGGTGAAGCAGCAGGAGCAGAAATACCCTCAGGGAGTCGCCTCAC
AGCGCAGCAAGTGAGGCTCCCACAGGCACCAGCAAAACAACGGATGAATGTAGCCCTTCCAACACCTGACAGAATGAGACCAAACGCAGC
CAGCCAGATCGGGAGCAAACCAAAGACCATCTGAGGAATGAGAAGTCTGCGGAGGCGGCCAGGGACTCTGCCGAGGCCCTGAGAACCCCA
GGGGCCGAGGAGGGGCGGGGAAGGTCAGCCAGGTTTGCCAGAACCACCGAGCCCCGCCTCCCGCCCCCCAGGGCTTCTGCAGGCTTCAGC
CATCCACTTCACCATCCACTCGGATCTCTCCTGAACTCCCACGACGCTATCCCTTTTAGTTGAACTAACATAGGTGAACGTGTTCAAAGC
CAAGCAAAATGCACACCCTTTTTCTGTGGCAAATCGTCTCTGTACATGTGTGTACATATTAGAAAGGGAAGATGTTAAGATATGTGGCCT
GTGGGTTACACAGGGTGCCTGCAGCGGTAATATATTTTAGAAATAATATATCAAATAACTCAACTAACTCCAATTTTTAATCAATTATTA
ATTTTTTTTTCTTTTTAAAGAGAAAGCAGGCTTTTCTAGACTTTAAAGAATAAAGTCTTTGGGAGGTCTCACGGTGTAGAGAGGAGCTTT
GAGGCCACCCGCACAAAATTCACCCAGAGGGAAATCTCGTCGGAAGGACACTCACGGCAGTTCTGGATCACCTGTGTATGTCAACAGAAG
GGATACCGTCTCCTTGAAGAGGAAACTCTGTCACTCCTCATGCCTGTCTAGCTCATACACCCATTTCTCTTTGCTTCACAGGTTTTAAAC
TGGTTTTTTGCATACTGCTATATAATTCTCTGTCTCTCTCTGTTTATCTCTCCCCTCCCTCCCCTCCCCTTCTTCTCCATCTCCATTCTT
TTGAATTTCCTCATCCCTCCATCTCAATCCCGTATCTACGCACCCCCCCCCCCCCAGGCAAAGCAGTGCTCTGAGTATCACATCACACAA
AAGGAACAAAAGCGAAACACACAAACCAGCCTCAACTTACACTTGGTTACTCAAAAGAACAAGAGTCAATGGTACTTGTCCTAGCGTTTT
GGAAGAGGAAAACAGGAACCCACCAAACCAACCAATCAACCAAACAAAGAAAAAATTCCACAATGAAAGAATGTATTTTGTCTTTTTGCA
TTTTGGTGTATAAGCCATCAATATTCAGCAAAATGATTCCTTTCTTTAAAAAAAAAAAATGTGGAGGAAAGTAGAAATTTACCAAGGTTG
TTGGCCCAGGGCGTTAAATTCACAGATTTTTTTAACGAGAAAAACACACAGAAGAAGCTACCTCAGGTGTTTTTACCTCAGCACCTTGCT
CTTGTGTTTCCCTTAGAGATTTTGTAAAGCTGATAGTTGGAGCATTTTTTTATTTTTTTAATAAAAATGAGTTGGAAAAAAAATAAGATA
TCAACTGCCAGCCTGGAGAAGGTGACAGTCCAAGTGTGCAACAGCTGTTCTGAATTGTCTTCCGCTAGCCAAGAACCTATATGGCCTTCT
TTTGGACAAACCTTGAAAATGTTTATTTAAAAAAAAAAAAGTGAACGAACTGCAGAACTTAACCAGTGCAGAAGTCATCGTGCCTCGTGA
CCAAACGCCAGATGAAAATGAGGAAGTGATCGTCAGAATTATCGGGCACTTCTTTGCTAGCCAGGCCCAGGGACGGATCTTTGGGAAACT
GAAAGAGGAAAACTTCTTTAACCCCAAAGAAGAAGTGAAGCTGGAAGCGCATATCAGAGTGCCCTCTTCCACAGCTGGCCGGGTGATTGG
CAAAGGTGGCAAGACCATTGCCCCTGCGGAAGGCCCAGACGTCAGCGAAAGGATGGTCATCATCACCGGGCCACCGGAAGCCCAGTTCAA
GTATCCAGAGCAGGAGATTGTGAATCTCTTCATCCCAACCCAGGCTGTGGGCGCCATCATCGGGAAGAAGGGGGCACACATCAAACAGCT
GGCGAGATTCGCCGGAGCCTCTATCAAGACCCACTCCGGATACTTCTCCAGCCTGTACCCCCATCACCAGTTTGGCCCGTTCCCGCATCA
TCACTCTCAACAAGCCAATCTGATCCCAGGGTTGAACCTCAGCGCACTTGGCATCTTTTCAACAGGACTGTCCGTGCTATCTCCACCAGC
AGGGCCCCGCGGAGCTCCCCCCGCTGCCCCCTACCACCCCTTCACTTTTGCAGGATTTGAGCATATACAACCCGGAAAGAACCATCACTG
TGAAGGGCACAGTTGAGGCCTGTGCCAGTGCTGAGATAGAGATTATGAAGAAGCTGCGTGAGGCCTTTGAAAATGATATGCTGGCTGTTA
ACAGCCGAAGAGATTCCTCTGAAAATCTTGGCACACAATGGCTTGGTTGGAAGACTGATTGGAAAAGAAGGCAGAAATTTGAAGAAAATT
GAACATGAAACAGGGACCAAGATAACAATCTCATCGGTAGATATCCATAGAAAAGAGAACTCTGGAGCTGCAGAGAAGCCTGTCACCATC
CATGCCACCCCAGAGGGGACTTCTGAAGCATGCCGCATGATTCTTGAAATCATGCAGAAAGAGGCAGATGAGACCAAACTAGCCATGGAG
AAGCTAAGCGGGCATCAGTTTGAGAACTACTCCTTCAAGATTTCCTACATCCCGGATGAAGAGGTGAGCTCCCCTTCGCCCCCTCAGCGA
GCCCAGCGTGGGGACCACTCTTCCCGGGAGCAAGGCCACGCCCCTGGGGGCACTTCTCAGGCCAGACAGATTGATTTCCCGCTGCGGATC
CTGGTCCCCACCCAGTTTGTTGGTGCCATCATCGGAAAGGAGGGCTTGACCATAAAGAACATCACTAAGCAGACCCAGTCCCGTCAACAC

>66318_66318_4_PLEKHM2-IGF2BP2_PLEKHM2_chr1_16046415_ENST00000375793_IGF2BP2_chr3_185410550_ENST00000457616_length(amino acids)=314AA_BP=
MAAAPGPRRGKRRRGGGGGGGGGGGDGGSAMEPGEVKDRILENISLSVKKLQSYFAACEDEIPAIRNHDKVLQRLCEHLDHALLYGLQDL
SSGYWVLVVHFTRREAIKQIEVLQHVATNLGRSRAWLYLALNENSLESYLRLFQENLGLLHKYYVKNALVCSHDHLTLFLTLVSGLEFIR
FELDLDAPYLDLAPYMPDYYKPQYLLDFEDRLPSSVHGSDSLSLNSFNSVTSTNLEWDDSAIAPSSEDCTAQDQGNCTTGEAAGAEIPSG

--------------------------------------------------------------
>66318_66318_5_PLEKHM2-IGF2BP2_PLEKHM2_chr1_16046415_ENST00000375799_IGF2BP2_chr3_185410550_ENST00000346192_length(transcript)=3766nt_BP=879nt
GCCTCCTTCCCCGCCGGCCGCGCTCCGGAGCCTCCGGGCCGCGGTGGAGCGAGGGCCCAGGCGAGGCGAGGGCCGGGCGGCGGGCGCCGG
GCCCCGCGGCCGGCACGACGGAGCCCCCGTACGGCCGGCGGCAGCGGTTGGCGGCGGCCCCCGGCCCCCGGCGCGGGAAGCGGCGGCGGG
GCGGCGGCGGCGGTGGCGGTGGCGGTGGCGGCGACGGTGGCAGCGCCATGGAGCCGGGGGAGGTGAAGGACCGGATCCTGGAGAACATCT
CGCTGTCGGTGAAGAAGTTGCAGAGCTATTTTGCTGCATGTGAGGATGAGATCCCTGCCATCCGGAACCATGACAAGGTCCTACAGCGTC
TGTGTGAGCACCTGGACCACGCCCTGCTGTACGGACTGCAAGACCTCTCCTCTGGCTACTGGGTGCTCGTGGTGCATTTTACTCGGAGAG
AGGCCATCAAGCAGATCGAGGTGCTGCAGCACGTGGCCACCAACCTGGGGCGCAGCCGTGCCTGGCTGTACCTGGCCCTCAACGAGAACT
CCTTGGAGAGCTACCTGCGGTTGTTCCAGGAGAACCTGGGCCTGCTGCATAAGTACTACGTCAAGAATGCCCTGGTCTGCAGCCACGATC
ACCTGACGCTCTTCCTGACCTTGGTGTCCGGGCTAGAGTTCATTCGTTTCGAGCTGGATCTGGATGCCCCTTACCTAGACCTGGCCCCCT
ACATGCCCGACTACTACAAACCTCAGTACCTGCTGGACTTTGAAGACCGCCTTCCCAGCTCGGTCCACGGCTCAGACAGTCTGTCCCTCA
ACTCTTTCAACTCCGTCACCTCCACCAACCTGGAGTGGGATGACAGTGCGATTGCCCCATCTAGTGAGGTCAACACAGACACAGAAACCG
CCGTTGTCAACGTCACATATGCAACAAGAGAAGAAGCAAAAATAGCCATGGAGAAGCTAAGCGGGCATCAGTTTGAGAACTACTCCTTCA
AGATTTCCTACATCCCGGATGAAGAGGTGAGCTCCCCTTCGCCCCCTCAGCGAGCCCAGCGTGGGGACCACTCTTCCCGGGAGCAAGGCC
ACGCCCCTGGGGGCACTTCTCAGGCCAGACAGATTGATTTCCCGCTGCGGATCCTGGTCCCCACCCAGTTTGTTGGTGCCATCATCGGAA
AGGAGGGCTTGACCATAAAGAACATCACTAAGCAGACCCAGTCCCGGGTAGATATCCATAGAAAAGAGAACTCTGGAGCTGCAGAGAAGC
CTGTCACCATCCATGCCACCCCAGAGGGGACTTCTGAAGCATGCCGCATGATTCTTGAAATCATGCAGAAAGAGGCAGATGAGACCAAAC
TAGCCGAAGAGATTCCTCTGAAAATCTTGGCACACAATGGCTTGGTTGGAAGACTGATTGGAAAAGAAGGCAGAAATTTGAAGAAAATTG
AACATGAAACAGGGACCAAGATAACAATCTCATCTTTGCAGGATTTGAGCATATACAACCCGGAAAGAACCATCACTGTGAAGGGCACAG
TTGAGGCCTGTGCCAGTGCTGAGATAGAGATTATGAAGAAGCTGCGTGAGGCCTTTGAAAATGATATGCTGGCTGTTAACACCCACTCCG
GATACTTCTCCAGCCTGTACCCCCATCACCAGTTTGGCCCGTTCCCGCATCATCACTCTTATCCAGAGCAGGAGATTGTGAATCTCTTCA
TCCCAACCCAGGCTGTGGGCGCCATCATCGGGAAGAAGGGGGCACACATCAAACAGCTGGCGAGATTCGCCGGAGCCTCTATCAAGATTG
CCCCTGCGGAAGGCCCAGACGTCAGCGAAAGGATGGTCATCATCACCGGGCCACCGGAAGCCCAGTTCAAGGCCCAGGGACGGATCTTTG
GGAAACTGAAAGAGGAAAACTTCTTTAACCCCAAAGAAGAAGTGAAGCTGGAAGCGCATATCAGAGTGCCCTCTTCCACAGCTGGCCGGG
TGATTGGCAAAGGTGGCAAGACCGTGAACGAACTGCAGAACTTAACCAGTGCAGAAGTCATCGTGCCTCGTGACCAAACGCCAGATGAAA
ATGAGGAAGTGATCGTCAGAATTATCGGGCACTTCTTTGCTAGCCAGACTGCACAGCGCAAGATCAGGGAAATTGTACAACAGGTGAAGC
AGCAGGAGCAGAAATACCCTCAGGGAGTCGCCTCACAGCGCAGCAAGTGAGGCTCCCACAGGCACCAGCAAAACAACGGATGAATGTAGC
CCTTCCAACACCTGACAGAATGAGACCAAACGCAGCCAGCCAGATCGGGAGCAAACCAAAGACCATCTGAGGAATGAGAAGTCTGCGGAG
GCGGCCAGGGACTCTGCCGAGGCCCTGAGAACCCCAGGGGCCGAGGAGGGGCGGGGAAGGTCAGCCAGGTTTGCCAGAACCACCGAGCCC
CGCCTCCCGCCCCCCAGGGCTTCTGCAGGCTTCAGCCATCCACTTCACCATCCACTCGGATCTCTCCTGAACTCCCACGACGCTATCCCT
TTTAGTTGAACTAACATAGGTGAACGTGTTCAAAGCCAAGCAAAATGCACACCCTTTTTCTGTGGCAAATCGTCTCTGTACATGTGTGTA
CATATTAGAAAGGGAAGATGTTAAGATATGTGGCCTGTGGGTTACACAGGGTGCCTGCAGCGGTAATATATTTTAGAAATAATATATCAA
ATAACTCAACTAACTCCAATTTTTAATCAATTATTAATTTTTTTTTCTTTTTAAAGAGAAAGCAGGCTTTTCTAGACTTTAAAGAATAAA
GTCTTTGGGAGGTCTCACGGTGTAGAGAGGAGCTTTGAGGCCACCCGCACAAAATTCACCCAGAGGGAAATCTCGTCGGAAGGACACTCA
CGGCAGTTCTGGATCACCTGTGTATGTCAACAGAAGGGATACCGTCTCCTTGAAGAGGAAACTCTGTCACTCCTCATGCCTGTCTAGCTC
ATACACCCATTTCTCTTTGCTTCACAGGTTTTAAACTGGTTTTTTGCATACTGCTATATAATTCTCTGTCTCTCTCTGTTTATCTCTCCC
CTCCCTCCCCTCCCCTTCTTCTCCATCTCCATTCTTTTGAATTTCCTCATCCCTCCATCTCAATCCCGTATCTACGCACCCCCCCCCCCC
CAGGCAAAGCAGTGCTCTGAGTATCACATCACACAAAAGGAACAAAAGCGAAACACACAAACCAGCCTCAACTTACACTTGGTTACTCAA
AAGAACAAGAGTCAATGGTACTTGTCCTAGCGTTTTGGAAGAGGAAAACAGGAACCCACCAAACCAACCAATCAACCAAACAAAGAAAAA
ATTCCACAATGAAAGAATGTATTTTGTCTTTTTGCATTTTGGTGTATAAGCCATCAATATTCAGCAAAATGATTCCTTTCTTTAAAAAAA
AAAAATGTGGAGGAAAGTAGAAATTTACCAAGGTTGTTGGCCCAGGGCGTTAAATTCACAGATTTTTTTAACGAGAAAAACACACAGAAG
AAGCTACCTCAGGTGTTTTTACCTCAGCACCTTGCTCTTGTGTTTCCCTTAGAGATTTTGTAAAGCTGATAGTTGGAGCATTTTTTTATT
TTTTTAATAAAAATGAGTTGGAAAAAAAATAAGATATCAACTGCCAGCCTGGAGAAGGTGACAGTCCAAGTGTGCAACAGCTGTTCTGAA

>66318_66318_5_PLEKHM2-IGF2BP2_PLEKHM2_chr1_16046415_ENST00000375799_IGF2BP2_chr3_185410550_ENST00000346192_length(amino acids)=690AA_BP=245
MAAAPGPRRGKRRRGGGGGGGGGGGDGGSAMEPGEVKDRILENISLSVKKLQSYFAACEDEIPAIRNHDKVLQRLCEHLDHALLYGLQDL
SSGYWVLVVHFTRREAIKQIEVLQHVATNLGRSRAWLYLALNENSLESYLRLFQENLGLLHKYYVKNALVCSHDHLTLFLTLVSGLEFIR
FELDLDAPYLDLAPYMPDYYKPQYLLDFEDRLPSSVHGSDSLSLNSFNSVTSTNLEWDDSAIAPSSEVNTDTETAVVNVTYATREEAKIA
MEKLSGHQFENYSFKISYIPDEEVSSPSPPQRAQRGDHSSREQGHAPGGTSQARQIDFPLRILVPTQFVGAIIGKEGLTIKNITKQTQSR
VDIHRKENSGAAEKPVTIHATPEGTSEACRMILEIMQKEADETKLAEEIPLKILAHNGLVGRLIGKEGRNLKKIEHETGTKITISSLQDL
SIYNPERTITVKGTVEACASAEIEIMKKLREAFENDMLAVNTHSGYFSSLYPHHQFGPFPHHHSYPEQEIVNLFIPTQAVGAIIGKKGAH
IKQLARFAGASIKIAPAEGPDVSERMVIITGPPEAQFKAQGRIFGKLKEENFFNPKEEVKLEAHIRVPSSTAGRVIGKGGKTVNELQNLT

--------------------------------------------------------------
>66318_66318_6_PLEKHM2-IGF2BP2_PLEKHM2_chr1_16046415_ENST00000375799_IGF2BP2_chr3_185410550_ENST00000382199_length(transcript)=4131nt_BP=879nt
GCCTCCTTCCCCGCCGGCCGCGCTCCGGAGCCTCCGGGCCGCGGTGGAGCGAGGGCCCAGGCGAGGCGAGGGCCGGGCGGCGGGCGCCGG
GCCCCGCGGCCGGCACGACGGAGCCCCCGTACGGCCGGCGGCAGCGGTTGGCGGCGGCCCCCGGCCCCCGGCGCGGGAAGCGGCGGCGGG
GCGGCGGCGGCGGTGGCGGTGGCGGTGGCGGCGACGGTGGCAGCGCCATGGAGCCGGGGGAGGTGAAGGACCGGATCCTGGAGAACATCT
CGCTGTCGGTGAAGAAGTTGCAGAGCTATTTTGCTGCATGTGAGGATGAGATCCCTGCCATCCGGAACCATGACAAGGTCCTACAGCGTC
TGTGTGAGCACCTGGACCACGCCCTGCTGTACGGACTGCAAGACCTCTCCTCTGGCTACTGGGTGCTCGTGGTGCATTTTACTCGGAGAG
AGGCCATCAAGCAGATCGAGGTGCTGCAGCACGTGGCCACCAACCTGGGGCGCAGCCGTGCCTGGCTGTACCTGGCCCTCAACGAGAACT
CCTTGGAGAGCTACCTGCGGTTGTTCCAGGAGAACCTGGGCCTGCTGCATAAGTACTACGTCAAGAATGCCCTGGTCTGCAGCCACGATC
ACCTGACGCTCTTCCTGACCTTGGTGTCCGGGCTAGAGTTCATTCGTTTCGAGCTGGATCTGGATGCCCCTTACCTAGACCTGGCCCCCT
ACATGCCCGACTACTACAAACCTCAGTACCTGCTGGACTTTGAAGACCGCCTTCCCAGCTCGGTCCACGGCTCAGACAGTCTGTCCCTCA
ACTCTTTCAACTCCGTCACCTCCACCAACCTGGAGTGGGATGACAGTGCGATTGCCCCATCTAGTGAGGTCAACACAGACACAGAAACCG
CCGTTGTCAACGTCACATATGCAACAAGAGAAGAAGCAAAAATAGCCATGGAGAAGCTAAGCGGGCATCAGTTTGAGAACTACTCCTTCA
AGATTTCCTACATCCCGGATGAAGAGGTGAGCTCCCCTTCGCCCCCTCAGCGAGCCCAGCGTGGGGACCACTCTTCCCGGGAGCAAGGCC
ACGCCCCTGGGGGCACTTCTCAGGCCAGACAGATTGATTTCCCGCTGCGGATCCTGGTCCCCACCCAGTTTGTTGGTGCCATCATCGGAA
AGGAGGGCTTGACCATAAAGAACATCACTAAGCAGACCCAGTCCCGGGTAGATATCCATAGAAAAGAGAACTCTGGAGCTGCAGAGAAGC
CTGTCACCATCCATGCCACCCCAGAGGGGACTTCTGAAGCATGCCGCATGATTCTTGAAATCATGCAGAAAGAGGCAGATGAGACCAAAC
TAGCCGAAGAGATTCCTCTGAAAATCTTGGCACACAATGGCTTGGTTGGAAGACTGATTGGAAAAGAAGGCAGAAATTTGAAGAAAATTG
AACATGAAACAGGGACCAAGATAACAATCTCATCTTTGCAGGATTTGAGCATATACAACCCGGAAAGAACCATCACTGTGAAGGGCACAG
TTGAGGCCTGTGCCAGTGCTGAGATAGAGATTATGAAGAAGCTGCGTGAGGCCTTTGAAAATGATATGCTGGCTGTTAACCAACAAGCCA
ATCTGATCCCAGGGTTGAACCTCAGCGCACTTGGCATCTTTTCAACAGGACTGTCCGTGCTATCTCCACCAGCAGGGCCCCGCGGAGCTC
CCCCCGCTGCCCCCTACCACCCCTTCACTACCCACTCCGGATACTTCTCCAGCCTGTACCCCCATCACCAGTTTGGCCCGTTCCCGCATC
ATCACTCTTATCCAGAGCAGGAGATTGTGAATCTCTTCATCCCAACCCAGGCTGTGGGCGCCATCATCGGGAAGAAGGGGGCACACATCA
AACAGCTGGCGAGATTCGCCGGAGCCTCTATCAAGATTGCCCCTGCGGAAGGCCCAGACGTCAGCGAAAGGATGGTCATCATCACCGGGC
CACCGGAAGCCCAGTTCAAGGCCCAGGGACGGATCTTTGGGAAACTGAAAGAGGAAAACTTCTTTAACCCCAAAGAAGAAGTGAAGCTGG
AAGCGCATATCAGAGTGCCCTCTTCCACAGCTGGCCGGGTGATTGGCAAAGGTGGCAAGACCGTGAACGAACTGCAGAACTTAACCAGTG
CAGAAGTCATCGTGCCTCGTGACCAAACGCCAGATGAAAATGAGGAAGTGATCGTCAGAATTATCGGGCACTTCTTTGCTAGCCAGACTG
CACAGCGCAAGATCAGGGAAATTGTACAACAGGTGAAGCAGCAGGAGCAGAAATACCCTCAGGGAGTCGCCTCACAGCGCAGCAAGTGAG
GCTCCCACAGGCACCAGCAAAACAACGGATGAATGTAGCCCTTCCAACACCTGACAGAATGAGACCAAACGCAGCCAGCCAGATCGGGAG
CAAACCAAAGACCATCTGAGGAATGAGAAGTCTGCGGAGGCGGCCAGGGACTCTGCCGAGGCCCTGAGAACCCCAGGGGCCGAGGAGGGG
CGGGGAAGGTCAGCCAGGTTTGCCAGAACCACCGAGCCCCGCCTCCCGCCCCCCAGGGCTTCTGCAGGCTTCAGCCATCCACTTCACCAT
CCACTCGGATCTCTCCTGAACTCCCACGACGCTATCCCTTTTAGTTGAACTAACATAGGTGAACGTGTTCAAAGCCAAGCAAAATGCACA
CCCTTTTTCTGTGGCAAATCGTCTCTGTACATGTGTGTACATATTAGAAAGGGAAGATGTTAAGATATGTGGCCTGTGGGTTACACAGGG
TGCCTGCAGCGGTAATATATTTTAGAAATAATATATCAAATAACTCAACTAACTCCAATTTTTAATCAATTATTAATTTTTTTTTCTTTT
TAAAGAGAAAGCAGGCTTTTCTAGACTTTAAAGAATAAAGTCTTTGGGAGGTCTCACGGTGTAGAGAGGAGCTTTGAGGCCACCCGCACA
AAATTCACCCAGAGGGAAATCTCGTCGGAAGGACACTCACGGCAGTTCTGGATCACCTGTGTATGTCAACAGAAGGGATACCGTCTCCTT
GAAGAGGAAACTCTGTCACTCCTCATGCCTGTCTAGCTCATACACCCATTTCTCTTTGCTTCACAGGTTTTAAACTGGTTTTTTGCATAC
TGCTATATAATTCTCTGTCTCTCTCTGTTTATCTCTCCCCTCCCTCCCCTCCCCTTCTTCTCCATCTCCATTCTTTTGAATTTCCTCATC
CCTCCATCTCAATCCCGTATCTACGCACCCCCCCCCCCCCAGGCAAAGCAGTGCTCTGAGTATCACATCACACAAAAGGAACAAAAGCGA
AACACACAAACCAGCCTCAACTTACACTTGGTTACTCAAAAGAACAAGAGTCAATGGTACTTGTCCTAGCGTTTTGGAAGAGGAAAACAG
GAACCCACCAAACCAACCAATCAACCAAACAAAGAAAAAATTCCACAATGAAAGAATGTATTTTGTCTTTTTGCATTTTGGTGTATAAGC
CATCAATATTCAGCAAAATGATTCCTTTCTTTAAAAAAAAAAAATGTGGAGGAAAGTAGAAATTTACCAAGGTTGTTGGCCCAGGGCGTT
AAATTCACAGATTTTTTTAACGAGAAAAACACACAGAAGAAGCTACCTCAGGTGTTTTTACCTCAGCACCTTGCTCTTGTGTTTCCCTTA
GAGATTTTGTAAAGCTGATAGTTGGAGCATTTTTTTATTTTTTTAATAAAAATGAGTTGGAAAAAAAATAAGATATCAACTGCCAGCCTG
GAGAAGGTGACAGTCCAAGTGTGCAACAGCTGTTCTGAATTGTCTTCCGCTAGCCAAGAACCTATATGGCCTTCTTTTGGACAAACCTTG
AAAATGTTTATTTAAAAAAAAAAAAGATGACAAAGAAAAACAGAGAGAGAGAATATTGGAGATGTCCTGAATTTTAATAGGGTACGCGCC
ATTAGGGCTTTTTGCGCTAAAGGATGAACATGTACTGGTTTATGTGGACAAGCCATTATACCACCAGACTGCAATGCCAGTTTCCTCTAC

>66318_66318_6_PLEKHM2-IGF2BP2_PLEKHM2_chr1_16046415_ENST00000375799_IGF2BP2_chr3_185410550_ENST00000382199_length(amino acids)=733AA_BP=245
MAAAPGPRRGKRRRGGGGGGGGGGGDGGSAMEPGEVKDRILENISLSVKKLQSYFAACEDEIPAIRNHDKVLQRLCEHLDHALLYGLQDL
SSGYWVLVVHFTRREAIKQIEVLQHVATNLGRSRAWLYLALNENSLESYLRLFQENLGLLHKYYVKNALVCSHDHLTLFLTLVSGLEFIR
FELDLDAPYLDLAPYMPDYYKPQYLLDFEDRLPSSVHGSDSLSLNSFNSVTSTNLEWDDSAIAPSSEVNTDTETAVVNVTYATREEAKIA
MEKLSGHQFENYSFKISYIPDEEVSSPSPPQRAQRGDHSSREQGHAPGGTSQARQIDFPLRILVPTQFVGAIIGKEGLTIKNITKQTQSR
VDIHRKENSGAAEKPVTIHATPEGTSEACRMILEIMQKEADETKLAEEIPLKILAHNGLVGRLIGKEGRNLKKIEHETGTKITISSLQDL
SIYNPERTITVKGTVEACASAEIEIMKKLREAFENDMLAVNQQANLIPGLNLSALGIFSTGLSVLSPPAGPRGAPPAAPYHPFTTHSGYF
SSLYPHHQFGPFPHHHSYPEQEIVNLFIPTQAVGAIIGKKGAHIKQLARFAGASIKIAPAEGPDVSERMVIITGPPEAQFKAQGRIFGKL
KEENFFNPKEEVKLEAHIRVPSSTAGRVIGKGGKTVNELQNLTSAEVIVPRDQTPDENEEVIVRIIGHFFASQTAQRKIREIVQQVKQQE

--------------------------------------------------------------
>66318_66318_7_PLEKHM2-IGF2BP2_PLEKHM2_chr1_16046415_ENST00000375799_IGF2BP2_chr3_185410550_ENST00000421047_length(transcript)=4068nt_BP=879nt
GCCTCCTTCCCCGCCGGCCGCGCTCCGGAGCCTCCGGGCCGCGGTGGAGCGAGGGCCCAGGCGAGGCGAGGGCCGGGCGGCGGGCGCCGG
GCCCCGCGGCCGGCACGACGGAGCCCCCGTACGGCCGGCGGCAGCGGTTGGCGGCGGCCCCCGGCCCCCGGCGCGGGAAGCGGCGGCGGG
GCGGCGGCGGCGGTGGCGGTGGCGGTGGCGGCGACGGTGGCAGCGCCATGGAGCCGGGGGAGGTGAAGGACCGGATCCTGGAGAACATCT
CGCTGTCGGTGAAGAAGTTGCAGAGCTATTTTGCTGCATGTGAGGATGAGATCCCTGCCATCCGGAACCATGACAAGGTCCTACAGCGTC
TGTGTGAGCACCTGGACCACGCCCTGCTGTACGGACTGCAAGACCTCTCCTCTGGCTACTGGGTGCTCGTGGTGCATTTTACTCGGAGAG
AGGCCATCAAGCAGATCGAGGTGCTGCAGCACGTGGCCACCAACCTGGGGCGCAGCCGTGCCTGGCTGTACCTGGCCCTCAACGAGAACT
CCTTGGAGAGCTACCTGCGGTTGTTCCAGGAGAACCTGGGCCTGCTGCATAAGTACTACGTCAAGAATGCCCTGGTCTGCAGCCACGATC
ACCTGACGCTCTTCCTGACCTTGGTGTCCGGGCTAGAGTTCATTCGTTTCGAGCTGGATCTGGATGCCCCTTACCTAGACCTGGCCCCCT
ACATGCCCGACTACTACAAACCTCAGTACCTGCTGGACTTTGAAGACCGCCTTCCCAGCTCGGTCCACGGCTCAGACAGTCTGTCCCTCA
ACTCTTTCAACTCCGTCACCTCCACCAACCTGGAGTGGGATGACAGTGCGATTGCCCCATCTAGTGAGGACTGCACAGCGCAAGATCAGG
GAAATTGTACAACAGGTGAAGCAGCAGGAGCAGAAATACCCTCAGGGAGTCGCCTCACAGCGCAGCAAGTGAGGCTCCCACAGGCACCAG
CAAAACAACGGATGAATGTAGCCCTTCCAACACCTGACAGAATGAGACCAAACGCAGCCAGCCAGATCGGGAGCAAACCAAAGACCATCT
GAGGAATGAGAAGTCTGCGGAGGCGGCCAGGGACTCTGCCGAGGCCCTGAGAACCCCAGGGGCCGAGGAGGGGCGGGGAAGGTCAGCCAG
GTTTGCCAGAACCACCGAGCCCCGCCTCCCGCCCCCCAGGGCTTCTGCAGGCTTCAGCCATCCACTTCACCATCCACTCGGATCTCTCCT
GAACTCCCACGACGCTATCCCTTTTAGTTGAACTAACATAGGTGAACGTGTTCAAAGCCAAGCAAAATGCACACCCTTTTTCTGTGGCAA
ATCGTCTCTGTACATGTGTGTACATATTAGAAAGGGAAGATGTTAAGATATGTGGCCTGTGGGTTACACAGGGTGCCTGCAGCGGTAATA
TATTTTAGAAATAATATATCAAATAACTCAACTAACTCCAATTTTTAATCAATTATTAATTTTTTTTTCTTTTTAAAGAGAAAGCAGGCT
TTTCTAGACTTTAAAGAATAAAGTCTTTGGGAGGTCTCACGGTGTAGAGAGGAGCTTTGAGGCCACCCGCACAAAATTCACCCAGAGGGA
AATCTCGTCGGAAGGACACTCACGGCAGTTCTGGATCACCTGTGTATGTCAACAGAAGGGATACCGTCTCCTTGAAGAGGAAACTCTGTC
ACTCCTCATGCCTGTCTAGCTCATACACCCATTTCTCTTTGCTTCACAGGTTTTAAACTGGTTTTTTGCATACTGCTATATAATTCTCTG
TCTCTCTCTGTTTATCTCTCCCCTCCCTCCCCTCCCCTTCTTCTCCATCTCCATTCTTTTGAATTTCCTCATCCCTCCATCTCAATCCCG
TATCTACGCACCCCCCCCCCCCCAGGCAAAGCAGTGCTCTGAGTATCACATCACACAAAAGGAACAAAAGCGAAACACACAAACCAGCCT
CAACTTACACTTGGTTACTCAAAAGAACAAGAGTCAATGGTACTTGTCCTAGCGTTTTGGAAGAGGAAAACAGGAACCCACCAAACCAAC
CAATCAACCAAACAAAGAAAAAATTCCACAATGAAAGAATGTATTTTGTCTTTTTGCATTTTGGTGTATAAGCCATCAATATTCAGCAAA
ATGATTCCTTTCTTTAAAAAAAAAAAATGTGGAGGAAAGTAGAAATTTACCAAGGTTGTTGGCCCAGGGCGTTAAATTCACAGATTTTTT
TAACGAGAAAAACACACAGAAGAAGCTACCTCAGGTGTTTTTACCTCAGCACCTTGCTCTTGTGTTTCCCTTAGAGATTTTGTAAAGCTG
ATAGTTGGAGCATTTTTTTATTTTTTTAATAAAAATGAGTTGGAAAAAAAATAAGATATCAACTGCCAGCCTGGAGAAGGTGACAGTCCA
AGTGTGCAACAGCTGTTCTGAATTGTCTTCCGCTAGCCAAGAACCTATATGGCCTTCTTTTGGACAAACCTTGAAAATGTTTATTTAAAA
AAAAAAAAGATGACAAAGAAAAACAGAGAGAGAGAATATTGGAGATGTCCTGAATTTTAATAGGGTACGCGCCATTAGGGCTTTTTGCGC
TAAAGGATGAACATGTACTGGTTTATGTGGACAAGCCATTATACCACCAGACTGCAATGCCAGTTTCCTCTACTGCAAACAGTGTTCTGT
GGTGAACGAACTGCAGAACTTAACCAGTGCAGAAGTCATCGTGCCTCGTGACCAAACGCCAGATGAAAATGAGGAAGTGATCGTCAGAAT
TATCGGGCACTTCTTTGCTAGCCAGGCCCAGGGACGGATCTTTGGGAAACTGAAAGAGGAAAACTTCTTTAACCCCAAAGAAGAAGTGAA
GCTGGAAGCGCATATCAGAGTGCCCTCTTCCACAGCTGGCCGGGTGATTGGCAAAGGTGGCAAGACCATTGCCCCTGCGGAAGGCCCAGA
CGTCAGCGAAAGGATGGTCATCATCACCGGGCCACCGGAAGCCCAGTTCAAGTATCCAGAGCAGGAGATTGTGAATCTCTTCATCCCAAC
CCAGGCTGTGGGCGCCATCATCGGGAAGAAGGGGGCACACATCAAACAGCTGGCGAGATTCGCCGGAGCCTCTATCAAGACCCACTCCGG
ATACTTCTCCAGCCTGTACCCCCATCACCAGTTTGGCCCGTTCCCGCATCATCACTCTCAACAAGCCAATCTGATCCCAGGGTTGAACCT
CAGCGCACTTGGCATCTTTTCAACAGGACTGTCCGTGCTATCTCCACCAGCAGGGCCCCGCGGAGCTCCCCCCGCTGCCCCCTACCACCC
CTTCACTTTTGCAGGATTTGAGCATATACAACCCGGAAAGAACCATCACTGTGAAGGGCACAGTTGAGGCCTGTGCCAGTGCTGAGATAG
AGATTATGAAGAAGCTGCGTGAGGCCTTTGAAAATGATATGCTGGCTGTTAACAGCCGAAGAGATTCCTCTGAAAATCTTGGCACACAAT
GGCTTGGTTGGAAGACTGATTGGAAAAGAAGGCAGAAATTTGAAGAAAATTGAACATGAAACAGGGACCAAGATAACAATCTCATCGGTA
GATATCCATAGAAAAGAGAACTCTGGAGCTGCAGAGAAGCCTGTCACCATCCATGCCACCCCAGAGGGGACTTCTGAAGCATGCCGCATG
ATTCTTGAAATCATGCAGAAAGAGGCAGATGAGACCAAACTAGCCATGGAGAAGCTAAGCGGGCATCAGTTTGAGAACTACTCCTTCAAG
ATTTCCTACATCCCGGATGAAGAGGTGAGCTCCCCTTCGCCCCCTCAGCGAGCCCAGCGTGGGGACCACTCTTCCCGGGAGCAAGGCCAC
GCCCCTGGGGGCACTTCTCAGGCCAGACAGATTGATTTCCCGCTGCGGATCCTGGTCCCCACCCAGTTTGTTGGTGCCATCATCGGAAAG
GAGGGCTTGACCATAAAGAACATCACTAAGCAGACCCAGTCCCGTCAACACAGACACAGAAACCGCCGTTGTCAACGTCACATATGCAAC

>66318_66318_7_PLEKHM2-IGF2BP2_PLEKHM2_chr1_16046415_ENST00000375799_IGF2BP2_chr3_185410550_ENST00000421047_length(amino acids)=314AA_BP=
MAAAPGPRRGKRRRGGGGGGGGGGGDGGSAMEPGEVKDRILENISLSVKKLQSYFAACEDEIPAIRNHDKVLQRLCEHLDHALLYGLQDL
SSGYWVLVVHFTRREAIKQIEVLQHVATNLGRSRAWLYLALNENSLESYLRLFQENLGLLHKYYVKNALVCSHDHLTLFLTLVSGLEFIR
FELDLDAPYLDLAPYMPDYYKPQYLLDFEDRLPSSVHGSDSLSLNSFNSVTSTNLEWDDSAIAPSSEDCTAQDQGNCTTGEAAGAEIPSG

--------------------------------------------------------------
>66318_66318_8_PLEKHM2-IGF2BP2_PLEKHM2_chr1_16046415_ENST00000375799_IGF2BP2_chr3_185410550_ENST00000457616_length(transcript)=3895nt_BP=879nt
GCCTCCTTCCCCGCCGGCCGCGCTCCGGAGCCTCCGGGCCGCGGTGGAGCGAGGGCCCAGGCGAGGCGAGGGCCGGGCGGCGGGCGCCGG
GCCCCGCGGCCGGCACGACGGAGCCCCCGTACGGCCGGCGGCAGCGGTTGGCGGCGGCCCCCGGCCCCCGGCGCGGGAAGCGGCGGCGGG
GCGGCGGCGGCGGTGGCGGTGGCGGTGGCGGCGACGGTGGCAGCGCCATGGAGCCGGGGGAGGTGAAGGACCGGATCCTGGAGAACATCT
CGCTGTCGGTGAAGAAGTTGCAGAGCTATTTTGCTGCATGTGAGGATGAGATCCCTGCCATCCGGAACCATGACAAGGTCCTACAGCGTC
TGTGTGAGCACCTGGACCACGCCCTGCTGTACGGACTGCAAGACCTCTCCTCTGGCTACTGGGTGCTCGTGGTGCATTTTACTCGGAGAG
AGGCCATCAAGCAGATCGAGGTGCTGCAGCACGTGGCCACCAACCTGGGGCGCAGCCGTGCCTGGCTGTACCTGGCCCTCAACGAGAACT
CCTTGGAGAGCTACCTGCGGTTGTTCCAGGAGAACCTGGGCCTGCTGCATAAGTACTACGTCAAGAATGCCCTGGTCTGCAGCCACGATC
ACCTGACGCTCTTCCTGACCTTGGTGTCCGGGCTAGAGTTCATTCGTTTCGAGCTGGATCTGGATGCCCCTTACCTAGACCTGGCCCCCT
ACATGCCCGACTACTACAAACCTCAGTACCTGCTGGACTTTGAAGACCGCCTTCCCAGCTCGGTCCACGGCTCAGACAGTCTGTCCCTCA
ACTCTTTCAACTCCGTCACCTCCACCAACCTGGAGTGGGATGACAGTGCGATTGCCCCATCTAGTGAGGACTGCACAGCGCAAGATCAGG
GAAATTGTACAACAGGTGAAGCAGCAGGAGCAGAAATACCCTCAGGGAGTCGCCTCACAGCGCAGCAAGTGAGGCTCCCACAGGCACCAG
CAAAACAACGGATGAATGTAGCCCTTCCAACACCTGACAGAATGAGACCAAACGCAGCCAGCCAGATCGGGAGCAAACCAAAGACCATCT
GAGGAATGAGAAGTCTGCGGAGGCGGCCAGGGACTCTGCCGAGGCCCTGAGAACCCCAGGGGCCGAGGAGGGGCGGGGAAGGTCAGCCAG
GTTTGCCAGAACCACCGAGCCCCGCCTCCCGCCCCCCAGGGCTTCTGCAGGCTTCAGCCATCCACTTCACCATCCACTCGGATCTCTCCT
GAACTCCCACGACGCTATCCCTTTTAGTTGAACTAACATAGGTGAACGTGTTCAAAGCCAAGCAAAATGCACACCCTTTTTCTGTGGCAA
ATCGTCTCTGTACATGTGTGTACATATTAGAAAGGGAAGATGTTAAGATATGTGGCCTGTGGGTTACACAGGGTGCCTGCAGCGGTAATA
TATTTTAGAAATAATATATCAAATAACTCAACTAACTCCAATTTTTAATCAATTATTAATTTTTTTTTCTTTTTAAAGAGAAAGCAGGCT
TTTCTAGACTTTAAAGAATAAAGTCTTTGGGAGGTCTCACGGTGTAGAGAGGAGCTTTGAGGCCACCCGCACAAAATTCACCCAGAGGGA
AATCTCGTCGGAAGGACACTCACGGCAGTTCTGGATCACCTGTGTATGTCAACAGAAGGGATACCGTCTCCTTGAAGAGGAAACTCTGTC
ACTCCTCATGCCTGTCTAGCTCATACACCCATTTCTCTTTGCTTCACAGGTTTTAAACTGGTTTTTTGCATACTGCTATATAATTCTCTG
TCTCTCTCTGTTTATCTCTCCCCTCCCTCCCCTCCCCTTCTTCTCCATCTCCATTCTTTTGAATTTCCTCATCCCTCCATCTCAATCCCG
TATCTACGCACCCCCCCCCCCCCAGGCAAAGCAGTGCTCTGAGTATCACATCACACAAAAGGAACAAAAGCGAAACACACAAACCAGCCT
CAACTTACACTTGGTTACTCAAAAGAACAAGAGTCAATGGTACTTGTCCTAGCGTTTTGGAAGAGGAAAACAGGAACCCACCAAACCAAC
CAATCAACCAAACAAAGAAAAAATTCCACAATGAAAGAATGTATTTTGTCTTTTTGCATTTTGGTGTATAAGCCATCAATATTCAGCAAA
ATGATTCCTTTCTTTAAAAAAAAAAAATGTGGAGGAAAGTAGAAATTTACCAAGGTTGTTGGCCCAGGGCGTTAAATTCACAGATTTTTT
TAACGAGAAAAACACACAGAAGAAGCTACCTCAGGTGTTTTTACCTCAGCACCTTGCTCTTGTGTTTCCCTTAGAGATTTTGTAAAGCTG
ATAGTTGGAGCATTTTTTTATTTTTTTAATAAAAATGAGTTGGAAAAAAAATAAGATATCAACTGCCAGCCTGGAGAAGGTGACAGTCCA
AGTGTGCAACAGCTGTTCTGAATTGTCTTCCGCTAGCCAAGAACCTATATGGCCTTCTTTTGGACAAACCTTGAAAATGTTTATTTAAAA
AAAAAAAAGTGAACGAACTGCAGAACTTAACCAGTGCAGAAGTCATCGTGCCTCGTGACCAAACGCCAGATGAAAATGAGGAAGTGATCG
TCAGAATTATCGGGCACTTCTTTGCTAGCCAGGCCCAGGGACGGATCTTTGGGAAACTGAAAGAGGAAAACTTCTTTAACCCCAAAGAAG
AAGTGAAGCTGGAAGCGCATATCAGAGTGCCCTCTTCCACAGCTGGCCGGGTGATTGGCAAAGGTGGCAAGACCATTGCCCCTGCGGAAG
GCCCAGACGTCAGCGAAAGGATGGTCATCATCACCGGGCCACCGGAAGCCCAGTTCAAGTATCCAGAGCAGGAGATTGTGAATCTCTTCA
TCCCAACCCAGGCTGTGGGCGCCATCATCGGGAAGAAGGGGGCACACATCAAACAGCTGGCGAGATTCGCCGGAGCCTCTATCAAGACCC
ACTCCGGATACTTCTCCAGCCTGTACCCCCATCACCAGTTTGGCCCGTTCCCGCATCATCACTCTCAACAAGCCAATCTGATCCCAGGGT
TGAACCTCAGCGCACTTGGCATCTTTTCAACAGGACTGTCCGTGCTATCTCCACCAGCAGGGCCCCGCGGAGCTCCCCCCGCTGCCCCCT
ACCACCCCTTCACTTTTGCAGGATTTGAGCATATACAACCCGGAAAGAACCATCACTGTGAAGGGCACAGTTGAGGCCTGTGCCAGTGCT
GAGATAGAGATTATGAAGAAGCTGCGTGAGGCCTTTGAAAATGATATGCTGGCTGTTAACAGCCGAAGAGATTCCTCTGAAAATCTTGGC
ACACAATGGCTTGGTTGGAAGACTGATTGGAAAAGAAGGCAGAAATTTGAAGAAAATTGAACATGAAACAGGGACCAAGATAACAATCTC
ATCGGTAGATATCCATAGAAAAGAGAACTCTGGAGCTGCAGAGAAGCCTGTCACCATCCATGCCACCCCAGAGGGGACTTCTGAAGCATG
CCGCATGATTCTTGAAATCATGCAGAAAGAGGCAGATGAGACCAAACTAGCCATGGAGAAGCTAAGCGGGCATCAGTTTGAGAACTACTC
CTTCAAGATTTCCTACATCCCGGATGAAGAGGTGAGCTCCCCTTCGCCCCCTCAGCGAGCCCAGCGTGGGGACCACTCTTCCCGGGAGCA
AGGCCACGCCCCTGGGGGCACTTCTCAGGCCAGACAGATTGATTTCCCGCTGCGGATCCTGGTCCCCACCCAGTTTGTTGGTGCCATCAT
CGGAAAGGAGGGCTTGACCATAAAGAACATCACTAAGCAGACCCAGTCCCGTCAACACAGACACAGAAACCGCCGTTGTCAACGTCACAT

>66318_66318_8_PLEKHM2-IGF2BP2_PLEKHM2_chr1_16046415_ENST00000375799_IGF2BP2_chr3_185410550_ENST00000457616_length(amino acids)=314AA_BP=
MAAAPGPRRGKRRRGGGGGGGGGGGDGGSAMEPGEVKDRILENISLSVKKLQSYFAACEDEIPAIRNHDKVLQRLCEHLDHALLYGLQDL
SSGYWVLVVHFTRREAIKQIEVLQHVATNLGRSRAWLYLALNENSLESYLRLFQENLGLLHKYYVKNALVCSHDHLTLFLTLVSGLEFIR
FELDLDAPYLDLAPYMPDYYKPQYLLDFEDRLPSSVHGSDSLSLNSFNSVTSTNLEWDDSAIAPSSEDCTAQDQGNCTTGEAAGAEIPSG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PLEKHM2-IGF2BP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgenePLEKHM2chr1:16046415chr3:185410550ENST00000375799+6201_310217.333333333333341020.0KIF5B
HgenePLEKHM2chr1:16046415chr3:185410550ENST00000375799+620762_885217.333333333333341020.0sifA


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PLEKHM2-IGF2BP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PLEKHM2-IGF2BP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource