FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:PLEKHS1-PDCD4 (FusionGDB2 ID:66338)

Fusion Gene Summary for PLEKHS1-PDCD4

check button Fusion gene summary
Fusion gene informationFusion gene name: PLEKHS1-PDCD4
Fusion gene ID: 66338
HgeneTgene
Gene symbol

PLEKHS1

PDCD4

Gene ID

79949

27250

Gene namepleckstrin homology domain containing S1programmed cell death 4
SynonymsC10orf81|HEL185H731
Cytomap

10q25.3

10q25.2

Type of geneprotein-codingprotein-coding
Descriptionpleckstrin homology domain-containing family S member 1PH domain-containing family S member 1PH domain-containing protein C10orf81epididymis luminal protein 185epididymis secretory sperm binding proteinprogrammed cell death protein 4neoplastic transformation inhibitor proteinnuclear antigen H731programmed cell death 4 (neoplastic transformation inhibitor)protein 197/15a
Modification date2020031320200329
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000361048, ENST00000369310, 
ENST00000369312, ENST00000354462, 
ENST00000369309, 		ENST00000481353, 
ENST00000280154, ENST00000393104, 
Fusion gene scores* DoF score3 X 2 X 3=185 X 6 X 5=150
# samples 36
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(6/150*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PLEKHS1 [Title/Abstract] AND PDCD4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPLEKHS1(115529659)-PDCD4(112645011), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePDCD4

GO:0007569

cell aging

12054647

TgenePDCD4

GO:0030509

BMP signaling pathway

18548003

TgenePDCD4

GO:0045892

negative regulation of transcription, DNA-templated

16357133

TgenePDCD4

GO:1905064

negative regulation of vascular smooth muscle cell differentiation

18548003


check buttonFusion gene breakpoints across PLEKHS1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PDCD4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A42U-01APLEKHS1chr10

115529659

+PDCD4chr10

112645011

+


Top

Fusion Gene ORF analysis for PLEKHS1-PDCD4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000361048ENST00000481353PLEKHS1chr10

115529659

+PDCD4chr10

112645011

+
5CDS-3UTRENST00000369310ENST00000481353PLEKHS1chr10

115529659

+PDCD4chr10

112645011

+
5CDS-3UTRENST00000369312ENST00000481353PLEKHS1chr10

115529659

+PDCD4chr10

112645011

+
In-frameENST00000361048ENST00000280154PLEKHS1chr10

115529659

+PDCD4chr10

112645011

+
In-frameENST00000361048ENST00000393104PLEKHS1chr10

115529659

+PDCD4chr10

112645011

+
In-frameENST00000369310ENST00000280154PLEKHS1chr10

115529659

+PDCD4chr10

112645011

+
In-frameENST00000369310ENST00000393104PLEKHS1chr10

115529659

+PDCD4chr10

112645011

+
In-frameENST00000369312ENST00000280154PLEKHS1chr10

115529659

+PDCD4chr10

112645011

+
In-frameENST00000369312ENST00000393104PLEKHS1chr10

115529659

+PDCD4chr10

112645011

+
intron-3CDSENST00000354462ENST00000280154PLEKHS1chr10

115529659

+PDCD4chr10

112645011

+
intron-3CDSENST00000354462ENST00000393104PLEKHS1chr10

115529659

+PDCD4chr10

112645011

+
intron-3CDSENST00000369309ENST00000280154PLEKHS1chr10

115529659

+PDCD4chr10

112645011

+
intron-3CDSENST00000369309ENST00000393104PLEKHS1chr10

115529659

+PDCD4chr10

112645011

+
intron-3UTRENST00000354462ENST00000481353PLEKHS1chr10

115529659

+PDCD4chr10

112645011

+
intron-3UTRENST00000369309ENST00000481353PLEKHS1chr10

115529659

+PDCD4chr10

112645011

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000361048PLEKHS1chr10115529659+ENST00000280154PDCD4chr10112645011+37668792821847521
ENST00000361048PLEKHS1chr10115529659+ENST00000393104PDCD4chr10112645011+37658792821847521
ENST00000369312PLEKHS1chr10115529659+ENST00000280154PDCD4chr10112645011+36387512231719498
ENST00000369312PLEKHS1chr10115529659+ENST00000393104PDCD4chr10112645011+36377512231719498
ENST00000369310PLEKHS1chr10115529659+ENST00000280154PDCD4chr10112645011+398310965622064500
ENST00000369310PLEKHS1chr10115529659+ENST00000393104PDCD4chr10112645011+398210965622064500

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000361048ENST00000280154PLEKHS1chr10115529659+PDCD4chr10112645011+0.0001941450.99980587
ENST00000361048ENST00000393104PLEKHS1chr10115529659+PDCD4chr10112645011+0.0001942920.99980575
ENST00000369312ENST00000280154PLEKHS1chr10115529659+PDCD4chr10112645011+0.0002956080.9997044
ENST00000369312ENST00000393104PLEKHS1chr10115529659+PDCD4chr10112645011+0.0002948950.99970514
ENST00000369310ENST00000280154PLEKHS1chr10115529659+PDCD4chr10112645011+0.0002469690.99975306
ENST00000369310ENST00000393104PLEKHS1chr10115529659+PDCD4chr10112645011+0.0002473430.9997527

Top

Fusion Genomic Features for PLEKHS1-PDCD4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PLEKHS1chr10115529659+PDCD4chr10112645010+3.59E-060.9999964
PLEKHS1chr10115529659+PDCD4chr10112645010+3.59E-060.9999964

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for PLEKHS1-PDCD4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:115529659/chr10:112645011)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePLEKHS1chr10:115529659chr10:112645011ENST00000361048+71214_129184364.0DomainPH
HgenePLEKHS1chr10:115529659chr10:112645011ENST00000369310+61214_129178466.0DomainPH
TgenePDCD4chr10:115529659chr10:112645011ENST00000280154312163_284147470.0DomainMI 1
TgenePDCD4chr10:115529659chr10:112645011ENST00000280154312326_449147470.0DomainMI 2
TgenePDCD4chr10:115529659chr10:112645011ENST00000393104413163_284136459.0DomainMI 1
TgenePDCD4chr10:115529659chr10:112645011ENST00000393104413326_449136459.0DomainMI 2
TgenePDCD4chr10:115529659chr10:112645011ENST00000280154312241_250147470.0MotifNuclear localization signal
TgenePDCD4chr10:115529659chr10:112645011ENST00000393104413241_250136459.0MotifNuclear localization signal

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePLEKHS1chr10:115529659chr10:112645011ENST00000354462+1614_1290199.0DomainPH
HgenePLEKHS1chr10:115529659chr10:112645011ENST00000369312+71314_12996367.0DomainPH
TgenePDCD4chr10:115529659chr10:112645011ENST0000028015431258_64147470.0MotifNuclear localization signal
TgenePDCD4chr10:115529659chr10:112645011ENST0000028015431270_76147470.0MotifNote=Phosphodegron
TgenePDCD4chr10:115529659chr10:112645011ENST0000039310441358_64136459.0MotifNuclear localization signal
TgenePDCD4chr10:115529659chr10:112645011ENST0000039310441370_76136459.0MotifNote=Phosphodegron


Top

Fusion Gene Sequence for PLEKHS1-PDCD4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>66338_66338_1_PLEKHS1-PDCD4_PLEKHS1_chr10_115529659_ENST00000361048_PDCD4_chr10_112645011_ENST00000280154_length(transcript)=3766nt_BP=879nt
ATTATTAATGTGTTTGCTTTCATTTTTGGTGCTAGGCAGCTGGGACACCAAGGAGAGTTCTGTGGCAAGCCACAAGTATGAAGGCCCAGA
ACTTCCCCTGAGGGCATAGCTTCCATTTCAGTTTGGGGCAAGAATAAAATCTGCTCAAGGATATTAGTTTGGGAACTTCCTGGTGGTTCA
GATTTCAAGCAGAGTTTGTGCTTAATCCTCACCCAGGCACCAAGGCTCAGAGTCAGCAGGAGTGAGTTCAGGAATCCTCGGGACAAGGCA
CTTTCCTGAGCACTGGACCAGCGACCTCTTGGCTTCCAGGGAGGACACACAGCCATCATGGAACCCAAACCTCAGAAGAGTCCAGGCAAA
CAATTTACATTTTCTTATGAAAATGAAGTCTGCAAACAAGATTACTTTATTAAATCACCACCTTCTCAGCTGTTCTCCTCTGTGACCTCT
TGGAAAAAGCGGTTTTTCATCCTGTCAAAGGCTGGGGAAAAGAGCTTTAGTCTTTCCTATTATAAAGACCATCATCACCGAGGTTCCATT
GAAATTGATCAAAATTCCAGTGTAGAAGTTGGCATAAGTAGCCAGGAAAAGATGCAATCTGTGCAGAAGATGTTTAAATGCCACCCTGAT
GAGGTCATGTCCATCAGAACCACTAACAGGGAATACTTCCTCATTGGCCACGACAGGGAGAAGATTAAAGACTGGGTCTCCTTCATGTCA
TCATTTCGCCAGGATATAAAAGCAACACAGCAGAACACAGAGGAGGAACTCTCATTGGGTAATAAAAGAACCCTCTTCTACTCCAGCCCT
CTCCTTGGCCCTTCCAGCACATCAGAGGCTGTTGGCTCCAGCTCACCAAGAAATGGTCTCCAAGACAAGGAGAACTGTGTTTATGAAACT
GTAGTTTTGCCTTTGGATGAAAGGGCATTTGAGAAGACTTTAACACCAATCATACAGGAATATTTTGAGCATGGAGATACTAATGAAGTT
GCGGAAATGTTAAGAGATTTAAATCTTGGTGAAATGAAAAGTGGAGTACCAGTGTTGGCAGTATCCTTAGCATTGGAGGGGAAGGCTAGT
CATAGAGAGATGACATCTAAGCTTCTTTCTGACCTTTGTGGGACAGTAATGAGCACAACTGATGTGGAAAAATCATTTGATAAATTGTTG
AAAGATCTACCTGAATTAGCACTGGATACTCCTAGAGCACCACAGTTGGTGGGCCAGTTTATTGCTAGAGCTGTTGGAGATGGAATTTTA
TGTAATACCTATATTGATAGTTACAAAGGAACTGTAGATTGTGTGCAGGCTAGAGCTGCTCTGGATAAGGCTACCGTGCTTCTGAGTATG
TCTAAAGGTGGAAAGCGTAAAGATAGTGTGTGGGGCTCTGGAGGTGGGCAGCAATCTGTCAATCACCTTGTTAAAGAGATTGATATGCTG
CTGAAAGAATATTTACTCTCTGGAGACATATCTGAAGCTGAACATTGCCTTAAGGAACTGGAAGTACCTCATTTTCACCATGAGCTTGTA
TATGAAGCTATTATAATGGTTTTAGAGTCAACTGGAGAAAGTACATTTAAGATGATTTTGGATTTATTAAAGTCCCTTTGGAAGTCTTCT
ACCATTACTGTAGACCAAATGAAAAGAGGTTATGAGAGAATTTACAATGAAATTCCGGACATTAATCTGGATGTCCCACATTCATACTCT
GTGCTGGAGCGGTTTGTAGAAGAATGTTTTCAGGCTGGAATAATTTCCAAACAACTCAGAGATCTTTGTCCTTCAAGGGGCAGAAAGCGT
TTTGTAAGCGAAGGAGATGGAGGTCGTCTTAAACCAGAGAGCTACTGAATATAAGAACTCTTGCAGTCTTAGATGTTATAAAAATATATA
TCTGAATTGTAAGAGTTGTTAGCACAAGTTTTTTTTTTTTTTTTTTTTAAGCACTTGTTTTGGGTACAAGGCATTTCTGACATTTTATAA
ACCTACATTTAAGGGGAATTTTTAAAGGAAATGTTTTTTCTTTTTTTTTTGTTTTTCGAGGGGGCAAGGAGGGACAGAAAAGTAACCTCT
TCTTAAGTGGAATATTCTAATAAGCTACCTTTTGTAAGTGCCATGTTTATTATCTAATCATTCCAAGTTTTGCATTGATGTCTGACTGCC
ACTCCTTTCTTTCAAGGACAGTGTTTTTTGTAGTAAAATCACTGGTTTATACAAAGCTTTATTTAGGGGGTAAAGTTAAGCTGCTAAAAC
CCCATGTTGGCTGCTGCTGTTGAGATACTGTGCTTTGGGAGTAAAAAAAGAAAGTTATTTCTTTGTCTTAAAGAATTTTTAAAAAATTAG
TCATGAGACTTATTCATCTTTCCAGGGAACATACTGATTGGTCTTAAAAGACTAGACAGTTAAGTAAAAGGTGGCTGGAACATCTATTTT
TCTACAAAACTGGAAAAATGAACCTGGTTCTAGAAGAATGTACACCAAAATAAAACATGTGAAGCAGTATTGATTCTTTATTGGGAGTAC
ATTTTTTTAGGTCTCTTAAACTTTAATTTCACACAGTAAATTTTGAATCTCATAAGGAAGCATATTTGAACCTAGTCAATTTAATCTTAG
TGTTCCCTTGAAAACTTTTTTTCCCTACAAAATTTTAAGTGAAAAATACAATAGTAAATTAAGATTACACTGGGGAAAAAAATGCAGGTA
TCACTTTACTCCATTGTTATCTGACCTAGAGCTTAATTAAGTTTTAGAAATATGTAATACCTTCCATCATTCCATCATCCTTAAATTCTG
TTACCAAATAATGGCTAATGTTACAAAAAGTTATACTCCAGAGACCCAAAGCTTGACATTTACCTAATGTATGAGAAAATATTACCAATT
AACAATAAAGAATGATCATATTTTTAACCTCTTTTACATAGCCTAATAACTCAGCAAGGCCTCAACGTCTGTGCTAATTTAAACTGCCAA
ATATTGACTGCAGCAAACAAGAATTATATTCAGAATTTATGAGGGTACTGTTAGGAGTATACTGCTTACAGGTTTAGATATAGTCTGTTA
GAATTAAAACCAAGTTTAGTGTTCATATTTACCTCATGGGCTTTATCAAGCCCATATTACCTCAGCTTATATATAGTTACCATTTTTAGG
TTTTTAATTGTTTGACACTTGGATGATAAATGCAGTCATTTTATTCTCAAGTGCTTAAAATTAATGTAATTAAAAGCTTAGCTGACTACA
GAATAGGTGAGGGTTTCTTAAAAATGAGATTTAAGGGCTGGGCACGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGG
GCGGATCACTTGAGGTTGGGAGTTCATGACCAGCTTGACCAACATGAAGAAACCCTGTCTCTATTAAAAATACAAAAGTAGCCAGGCATG
GTGGCGCATGCGTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATTGCTTGAACCTGGGAGGCAGAGGTTGCAGTGAGTCGAGAT
GGTGCCATTGCTCTCGTTTGGGCAACAAGAGTGAAACTCTTGTCTCAAAAAAAAAAAAAAATGAGGTTTAAGACAGTTTTGTCATTACTG
GTGGGATCTGGTCACACAAGATAGCATTAAACGTGACATGGCACATAAAATTGGTTAAAAAATTTTGTTTTTTAATTACGTAATGTAAAA

>66338_66338_1_PLEKHS1-PDCD4_PLEKHS1_chr10_115529659_ENST00000361048_PDCD4_chr10_112645011_ENST00000280154_length(amino acids)=521AA_BP=198
MDQRPLGFQGGHTAIMEPKPQKSPGKQFTFSYENEVCKQDYFIKSPPSQLFSSVTSWKKRFFILSKAGEKSFSLSYYKDHHHRGSIEIDQ
NSSVEVGISSQEKMQSVQKMFKCHPDEVMSIRTTNREYFLIGHDREKIKDWVSFMSSFRQDIKATQQNTEEELSLGNKRTLFYSSPLLGP
SSTSEAVGSSSPRNGLQDKENCVYETVVLPLDERAFEKTLTPIIQEYFEHGDTNEVAEMLRDLNLGEMKSGVPVLAVSLALEGKASHREM
TSKLLSDLCGTVMSTTDVEKSFDKLLKDLPELALDTPRAPQLVGQFIARAVGDGILCNTYIDSYKGTVDCVQARAALDKATVLLSMSKGG
KRKDSVWGSGGGQQSVNHLVKEIDMLLKEYLLSGDISEAEHCLKELEVPHFHHELVYEAIIMVLESTGESTFKMILDLLKSLWKSSTITV

--------------------------------------------------------------
>66338_66338_2_PLEKHS1-PDCD4_PLEKHS1_chr10_115529659_ENST00000361048_PDCD4_chr10_112645011_ENST00000393104_length(transcript)=3765nt_BP=879nt
ATTATTAATGTGTTTGCTTTCATTTTTGGTGCTAGGCAGCTGGGACACCAAGGAGAGTTCTGTGGCAAGCCACAAGTATGAAGGCCCAGA
ACTTCCCCTGAGGGCATAGCTTCCATTTCAGTTTGGGGCAAGAATAAAATCTGCTCAAGGATATTAGTTTGGGAACTTCCTGGTGGTTCA
GATTTCAAGCAGAGTTTGTGCTTAATCCTCACCCAGGCACCAAGGCTCAGAGTCAGCAGGAGTGAGTTCAGGAATCCTCGGGACAAGGCA
CTTTCCTGAGCACTGGACCAGCGACCTCTTGGCTTCCAGGGAGGACACACAGCCATCATGGAACCCAAACCTCAGAAGAGTCCAGGCAAA
CAATTTACATTTTCTTATGAAAATGAAGTCTGCAAACAAGATTACTTTATTAAATCACCACCTTCTCAGCTGTTCTCCTCTGTGACCTCT
TGGAAAAAGCGGTTTTTCATCCTGTCAAAGGCTGGGGAAAAGAGCTTTAGTCTTTCCTATTATAAAGACCATCATCACCGAGGTTCCATT
GAAATTGATCAAAATTCCAGTGTAGAAGTTGGCATAAGTAGCCAGGAAAAGATGCAATCTGTGCAGAAGATGTTTAAATGCCACCCTGAT
GAGGTCATGTCCATCAGAACCACTAACAGGGAATACTTCCTCATTGGCCACGACAGGGAGAAGATTAAAGACTGGGTCTCCTTCATGTCA
TCATTTCGCCAGGATATAAAAGCAACACAGCAGAACACAGAGGAGGAACTCTCATTGGGTAATAAAAGAACCCTCTTCTACTCCAGCCCT
CTCCTTGGCCCTTCCAGCACATCAGAGGCTGTTGGCTCCAGCTCACCAAGAAATGGTCTCCAAGACAAGGAGAACTGTGTTTATGAAACT
GTAGTTTTGCCTTTGGATGAAAGGGCATTTGAGAAGACTTTAACACCAATCATACAGGAATATTTTGAGCATGGAGATACTAATGAAGTT
GCGGAAATGTTAAGAGATTTAAATCTTGGTGAAATGAAAAGTGGAGTACCAGTGTTGGCAGTATCCTTAGCATTGGAGGGGAAGGCTAGT
CATAGAGAGATGACATCTAAGCTTCTTTCTGACCTTTGTGGGACAGTAATGAGCACAACTGATGTGGAAAAATCATTTGATAAATTGTTG
AAAGATCTACCTGAATTAGCACTGGATACTCCTAGAGCACCACAGTTGGTGGGCCAGTTTATTGCTAGAGCTGTTGGAGATGGAATTTTA
TGTAATACCTATATTGATAGTTACAAAGGAACTGTAGATTGTGTGCAGGCTAGAGCTGCTCTGGATAAGGCTACCGTGCTTCTGAGTATG
TCTAAAGGTGGAAAGCGTAAAGATAGTGTGTGGGGCTCTGGAGGTGGGCAGCAATCTGTCAATCACCTTGTTAAAGAGATTGATATGCTG
CTGAAAGAATATTTACTCTCTGGAGACATATCTGAAGCTGAACATTGCCTTAAGGAACTGGAAGTACCTCATTTTCACCATGAGCTTGTA
TATGAAGCTATTATAATGGTTTTAGAGTCAACTGGAGAAAGTACATTTAAGATGATTTTGGATTTATTAAAGTCCCTTTGGAAGTCTTCT
ACCATTACTGTAGACCAAATGAAAAGAGGTTATGAGAGAATTTACAATGAAATTCCGGACATTAATCTGGATGTCCCACATTCATACTCT
GTGCTGGAGCGGTTTGTAGAAGAATGTTTTCAGGCTGGAATAATTTCCAAACAACTCAGAGATCTTTGTCCTTCAAGGGGCAGAAAGCGT
TTTGTAAGCGAAGGAGATGGAGGTCGTCTTAAACCAGAGAGCTACTGAATATAAGAACTCTTGCAGTCTTAGATGTTATAAAAATATATA
TCTGAATTGTAAGAGTTGTTAGCACAAGTTTTTTTTTTTTTTTTTTTTAAGCACTTGTTTTGGGTACAAGGCATTTCTGACATTTTATAA
ACCTACATTTAAGGGGAATTTTTAAAGGAAATGTTTTTTCTTTTTTTTTTGTTTTTCGAGGGGGCAAGGAGGGACAGAAAAGTAACCTCT
TCTTAAGTGGAATATTCTAATAAGCTACCTTTTGTAAGTGCCATGTTTATTATCTAATCATTCCAAGTTTTGCATTGATGTCTGACTGCC
ACTCCTTTCTTTCAAGGACAGTGTTTTTTGTAGTAAAATCACTGGTTTATACAAAGCTTTATTTAGGGGGTAAAGTTAAGCTGCTAAAAC
CCCATGTTGGCTGCTGCTGTTGAGATACTGTGCTTTGGGAGTAAAAAAAGAAAGTTATTTCTTTGTCTTAAAGAATTTTTAAAAAATTAG
TCATGAGACTTATTCATCTTTCCAGGGAACATACTGATTGGTCTTAAAAGACTAGACAGTTAAGTAAAAGGTGGCTGGAACATCTATTTT
TCTACAAAACTGGAAAAATGAACCTGGTTCTAGAAGAATGTACACCAAAATAAAACATGTGAAGCAGTATTGATTCTTTATTGGGAGTAC
ATTTTTTTAGGTCTCTTAAACTTTAATTTCACACAGTAAATTTTGAATCTCATAAGGAAGCATATTTGAACCTAGTCAATTTAATCTTAG
TGTTCCCTTGAAAACTTTTTTTCCCTACAAAATTTTAAGTGAAAAATACAATAGTAAATTAAGATTACACTGGGGAAAAAAATGCAGGTA
TCACTTTACTCCATTGTTATCTGACCTAGAGCTTAATTAAGTTTTAGAAATATGTAATACCTTCCATCATTCCATCATCCTTAAATTCTG
TTACCAAATAATGGCTAATGTTACAAAAAGTTATACTCCAGAGACCCAAAGCTTGACATTTACCTAATGTATGAGAAAATATTACCAATT
AACAATAAAGAATGATCATATTTTTAACCTCTTTTACATAGCCTAATAACTCAGCAAGGCCTCAACGTCTGTGCTAATTTAAACTGCCAA
ATATTGACTGCAGCAAACAAGAATTATATTCAGAATTTATGAGGGTACTGTTAGGAGTATACTGCTTACAGGTTTAGATATAGTCTGTTA
GAATTAAAACCAAGTTTAGTGTTCATATTTACCTCATGGGCTTTATCAAGCCCATATTACCTCAGCTTATATATAGTTACCATTTTTAGG
TTTTTAATTGTTTGACACTTGGATGATAAATGCAGTCATTTTATTCTCAAGTGCTTAAAATTAATGTAATTAAAAGCTTAGCTGACTACA
GAATAGGTGAGGGTTTCTTAAAAATGAGATTTAAGGGCTGGGCACGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGG
GCGGATCACTTGAGGTTGGGAGTTCATGACCAGCTTGACCAACATGAAGAAACCCTGTCTCTATTAAAAATACAAAAGTAGCCAGGCATG
GTGGCGCATGCGTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATTGCTTGAACCTGGGAGGCAGAGGTTGCAGTGAGTCGAGAT
GGTGCCATTGCTCTCGTTTGGGCAACAAGAGTGAAACTCTTGTCTCAAAAAAAAAAAAAAATGAGGTTTAAGACAGTTTTGTCATTACTG
GTGGGATCTGGTCACACAAGATAGCATTAAACGTGACATGGCACATAAAATTGGTTAAAAAATTTTGTTTTTTAATTACGTAATGTAAAA

>66338_66338_2_PLEKHS1-PDCD4_PLEKHS1_chr10_115529659_ENST00000361048_PDCD4_chr10_112645011_ENST00000393104_length(amino acids)=521AA_BP=198
MDQRPLGFQGGHTAIMEPKPQKSPGKQFTFSYENEVCKQDYFIKSPPSQLFSSVTSWKKRFFILSKAGEKSFSLSYYKDHHHRGSIEIDQ
NSSVEVGISSQEKMQSVQKMFKCHPDEVMSIRTTNREYFLIGHDREKIKDWVSFMSSFRQDIKATQQNTEEELSLGNKRTLFYSSPLLGP
SSTSEAVGSSSPRNGLQDKENCVYETVVLPLDERAFEKTLTPIIQEYFEHGDTNEVAEMLRDLNLGEMKSGVPVLAVSLALEGKASHREM
TSKLLSDLCGTVMSTTDVEKSFDKLLKDLPELALDTPRAPQLVGQFIARAVGDGILCNTYIDSYKGTVDCVQARAALDKATVLLSMSKGG
KRKDSVWGSGGGQQSVNHLVKEIDMLLKEYLLSGDISEAEHCLKELEVPHFHHELVYEAIIMVLESTGESTFKMILDLLKSLWKSSTITV

--------------------------------------------------------------
>66338_66338_3_PLEKHS1-PDCD4_PLEKHS1_chr10_115529659_ENST00000369310_PDCD4_chr10_112645011_ENST00000280154_length(transcript)=3983nt_BP=1096nt
ATGCCTTTAAGTGCACTAATCTTTTCTTGTACAATATTTAATCTGCTCTTACTCCCATCCAGTGTTGTTGCTGTTTTTTTGAGACATTGT
AGTTTTCATCTTTAAAATTTCACTTTAGGTCTTCTTTATATCTTTTATATCTCTCCCTAACTTTTTGAAAATATAGTGATAATAACTGCT
TTAATTACTTTCTCTGCCAATTCTAACATCTGTGTCAGTTCTAGGCCTGTTTTGATTGATTGACTTTCTTCTCATTATTGATCATGTTTT
CCTTCCTCTTTGTATGCCTGGTAAACTTTGATTGACTGCCAAACATCGCAAATTTTACCTTGTTGTTTCCTGAATATCTTTGTATTCCTA
TGAATCTTGAGCTTTGTTCTGGGATACAGTTAAATTTTTTGGGAACAACTTTCTTCTAAGTCTTTCATGATTTTTTAGGTGGGTTTGGAG
CAGTGCTCAGTGTAGAACTAGTAATTAGTGTAGAGCTAATTATTCCTCACACTGAGGCAAGACATTCCTGAGTACTCTACCCAATGCCCT
GTAAATTATAAGTTTTTCCAGTATGGCTGGAGGCAAACAATTTACATTTTCTTATGAAAATGAAGTCTGCAAACAAGATTACTTTATTAA
ATCACCACCTTCTCAGCTGTTCTCCTCTGTGACCTCTTGGAAAAAGCGGTTTTTCATCCTGTCAAAGGCTGGGGAAAAGAGCTTTAGTCT
TTCCTATTATAAAGACCATCATCACCGAGGTTCCATTGAAATTGATCAAAATTCCAGTGTAGAAGTTGGCATAAGTAGCCAGGAAAAGAT
GCAATCTGTGCAGAAGATGTTTAAATGCCACCCTGATGAGGTCATGTCCATCAGAACCACTAACAGGGAATACTTCCTCATTGGCCACGA
CAGGGAGAAGATTAAAGACTGGGTCTCCTTCATGTCATCATTTCGCCAGGATATAAAAGCAACACAGCAGAACACAGAGGAGGAACTCTC
ATTGGGTAATAAAAGAACCCTCTTCTACTCCAGCCCTCTCCTTGGCCCTTCCAGCACATCAGAGGCTGTTGGCTCCAGCTCACCAAGAAA
TGGTCTCCAAGACAAGGAGAACTGTGTTTATGAAACTGTAGTTTTGCCTTTGGATGAAAGGGCATTTGAGAAGACTTTAACACCAATCAT
ACAGGAATATTTTGAGCATGGAGATACTAATGAAGTTGCGGAAATGTTAAGAGATTTAAATCTTGGTGAAATGAAAAGTGGAGTACCAGT
GTTGGCAGTATCCTTAGCATTGGAGGGGAAGGCTAGTCATAGAGAGATGACATCTAAGCTTCTTTCTGACCTTTGTGGGACAGTAATGAG
CACAACTGATGTGGAAAAATCATTTGATAAATTGTTGAAAGATCTACCTGAATTAGCACTGGATACTCCTAGAGCACCACAGTTGGTGGG
CCAGTTTATTGCTAGAGCTGTTGGAGATGGAATTTTATGTAATACCTATATTGATAGTTACAAAGGAACTGTAGATTGTGTGCAGGCTAG
AGCTGCTCTGGATAAGGCTACCGTGCTTCTGAGTATGTCTAAAGGTGGAAAGCGTAAAGATAGTGTGTGGGGCTCTGGAGGTGGGCAGCA
ATCTGTCAATCACCTTGTTAAAGAGATTGATATGCTGCTGAAAGAATATTTACTCTCTGGAGACATATCTGAAGCTGAACATTGCCTTAA
GGAACTGGAAGTACCTCATTTTCACCATGAGCTTGTATATGAAGCTATTATAATGGTTTTAGAGTCAACTGGAGAAAGTACATTTAAGAT
GATTTTGGATTTATTAAAGTCCCTTTGGAAGTCTTCTACCATTACTGTAGACCAAATGAAAAGAGGTTATGAGAGAATTTACAATGAAAT
TCCGGACATTAATCTGGATGTCCCACATTCATACTCTGTGCTGGAGCGGTTTGTAGAAGAATGTTTTCAGGCTGGAATAATTTCCAAACA
ACTCAGAGATCTTTGTCCTTCAAGGGGCAGAAAGCGTTTTGTAAGCGAAGGAGATGGAGGTCGTCTTAAACCAGAGAGCTACTGAATATA
AGAACTCTTGCAGTCTTAGATGTTATAAAAATATATATCTGAATTGTAAGAGTTGTTAGCACAAGTTTTTTTTTTTTTTTTTTTTAAGCA
CTTGTTTTGGGTACAAGGCATTTCTGACATTTTATAAACCTACATTTAAGGGGAATTTTTAAAGGAAATGTTTTTTCTTTTTTTTTTGTT
TTTCGAGGGGGCAAGGAGGGACAGAAAAGTAACCTCTTCTTAAGTGGAATATTCTAATAAGCTACCTTTTGTAAGTGCCATGTTTATTAT
CTAATCATTCCAAGTTTTGCATTGATGTCTGACTGCCACTCCTTTCTTTCAAGGACAGTGTTTTTTGTAGTAAAATCACTGGTTTATACA
AAGCTTTATTTAGGGGGTAAAGTTAAGCTGCTAAAACCCCATGTTGGCTGCTGCTGTTGAGATACTGTGCTTTGGGAGTAAAAAAAGAAA
GTTATTTCTTTGTCTTAAAGAATTTTTAAAAAATTAGTCATGAGACTTATTCATCTTTCCAGGGAACATACTGATTGGTCTTAAAAGACT
AGACAGTTAAGTAAAAGGTGGCTGGAACATCTATTTTTCTACAAAACTGGAAAAATGAACCTGGTTCTAGAAGAATGTACACCAAAATAA
AACATGTGAAGCAGTATTGATTCTTTATTGGGAGTACATTTTTTTAGGTCTCTTAAACTTTAATTTCACACAGTAAATTTTGAATCTCAT
AAGGAAGCATATTTGAACCTAGTCAATTTAATCTTAGTGTTCCCTTGAAAACTTTTTTTCCCTACAAAATTTTAAGTGAAAAATACAATA
GTAAATTAAGATTACACTGGGGAAAAAAATGCAGGTATCACTTTACTCCATTGTTATCTGACCTAGAGCTTAATTAAGTTTTAGAAATAT
GTAATACCTTCCATCATTCCATCATCCTTAAATTCTGTTACCAAATAATGGCTAATGTTACAAAAAGTTATACTCCAGAGACCCAAAGCT
TGACATTTACCTAATGTATGAGAAAATATTACCAATTAACAATAAAGAATGATCATATTTTTAACCTCTTTTACATAGCCTAATAACTCA
GCAAGGCCTCAACGTCTGTGCTAATTTAAACTGCCAAATATTGACTGCAGCAAACAAGAATTATATTCAGAATTTATGAGGGTACTGTTA
GGAGTATACTGCTTACAGGTTTAGATATAGTCTGTTAGAATTAAAACCAAGTTTAGTGTTCATATTTACCTCATGGGCTTTATCAAGCCC
ATATTACCTCAGCTTATATATAGTTACCATTTTTAGGTTTTTAATTGTTTGACACTTGGATGATAAATGCAGTCATTTTATTCTCAAGTG
CTTAAAATTAATGTAATTAAAAGCTTAGCTGACTACAGAATAGGTGAGGGTTTCTTAAAAATGAGATTTAAGGGCTGGGCACGGTGGCTC
ATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGCGGATCACTTGAGGTTGGGAGTTCATGACCAGCTTGACCAACATGAAGAAAC
CCTGTCTCTATTAAAAATACAAAAGTAGCCAGGCATGGTGGCGCATGCGTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATTGC
TTGAACCTGGGAGGCAGAGGTTGCAGTGAGTCGAGATGGTGCCATTGCTCTCGTTTGGGCAACAAGAGTGAAACTCTTGTCTCAAAAAAA
AAAAAAAATGAGGTTTAAGACAGTTTTGTCATTACTGGTGGGATCTGGTCACACAAGATAGCATTAAACGTGACATGGCACATAAAATTG
GTTAAAAAATTTTGTTTTTTAATTACGTAATGTAAAAGCCCAACAAACACTTTATGCAAGATTGGAATGTATCTTCAAATTCAGATTTAA

>66338_66338_3_PLEKHS1-PDCD4_PLEKHS1_chr10_115529659_ENST00000369310_PDCD4_chr10_112645011_ENST00000280154_length(amino acids)=500AA_BP=177
MAGGKQFTFSYENEVCKQDYFIKSPPSQLFSSVTSWKKRFFILSKAGEKSFSLSYYKDHHHRGSIEIDQNSSVEVGISSQEKMQSVQKMF
KCHPDEVMSIRTTNREYFLIGHDREKIKDWVSFMSSFRQDIKATQQNTEEELSLGNKRTLFYSSPLLGPSSTSEAVGSSSPRNGLQDKEN
CVYETVVLPLDERAFEKTLTPIIQEYFEHGDTNEVAEMLRDLNLGEMKSGVPVLAVSLALEGKASHREMTSKLLSDLCGTVMSTTDVEKS
FDKLLKDLPELALDTPRAPQLVGQFIARAVGDGILCNTYIDSYKGTVDCVQARAALDKATVLLSMSKGGKRKDSVWGSGGGQQSVNHLVK
EIDMLLKEYLLSGDISEAEHCLKELEVPHFHHELVYEAIIMVLESTGESTFKMILDLLKSLWKSSTITVDQMKRGYERIYNEIPDINLDV

--------------------------------------------------------------
>66338_66338_4_PLEKHS1-PDCD4_PLEKHS1_chr10_115529659_ENST00000369310_PDCD4_chr10_112645011_ENST00000393104_length(transcript)=3982nt_BP=1096nt
ATGCCTTTAAGTGCACTAATCTTTTCTTGTACAATATTTAATCTGCTCTTACTCCCATCCAGTGTTGTTGCTGTTTTTTTGAGACATTGT
AGTTTTCATCTTTAAAATTTCACTTTAGGTCTTCTTTATATCTTTTATATCTCTCCCTAACTTTTTGAAAATATAGTGATAATAACTGCT
TTAATTACTTTCTCTGCCAATTCTAACATCTGTGTCAGTTCTAGGCCTGTTTTGATTGATTGACTTTCTTCTCATTATTGATCATGTTTT
CCTTCCTCTTTGTATGCCTGGTAAACTTTGATTGACTGCCAAACATCGCAAATTTTACCTTGTTGTTTCCTGAATATCTTTGTATTCCTA
TGAATCTTGAGCTTTGTTCTGGGATACAGTTAAATTTTTTGGGAACAACTTTCTTCTAAGTCTTTCATGATTTTTTAGGTGGGTTTGGAG
CAGTGCTCAGTGTAGAACTAGTAATTAGTGTAGAGCTAATTATTCCTCACACTGAGGCAAGACATTCCTGAGTACTCTACCCAATGCCCT
GTAAATTATAAGTTTTTCCAGTATGGCTGGAGGCAAACAATTTACATTTTCTTATGAAAATGAAGTCTGCAAACAAGATTACTTTATTAA
ATCACCACCTTCTCAGCTGTTCTCCTCTGTGACCTCTTGGAAAAAGCGGTTTTTCATCCTGTCAAAGGCTGGGGAAAAGAGCTTTAGTCT
TTCCTATTATAAAGACCATCATCACCGAGGTTCCATTGAAATTGATCAAAATTCCAGTGTAGAAGTTGGCATAAGTAGCCAGGAAAAGAT
GCAATCTGTGCAGAAGATGTTTAAATGCCACCCTGATGAGGTCATGTCCATCAGAACCACTAACAGGGAATACTTCCTCATTGGCCACGA
CAGGGAGAAGATTAAAGACTGGGTCTCCTTCATGTCATCATTTCGCCAGGATATAAAAGCAACACAGCAGAACACAGAGGAGGAACTCTC
ATTGGGTAATAAAAGAACCCTCTTCTACTCCAGCCCTCTCCTTGGCCCTTCCAGCACATCAGAGGCTGTTGGCTCCAGCTCACCAAGAAA
TGGTCTCCAAGACAAGGAGAACTGTGTTTATGAAACTGTAGTTTTGCCTTTGGATGAAAGGGCATTTGAGAAGACTTTAACACCAATCAT
ACAGGAATATTTTGAGCATGGAGATACTAATGAAGTTGCGGAAATGTTAAGAGATTTAAATCTTGGTGAAATGAAAAGTGGAGTACCAGT
GTTGGCAGTATCCTTAGCATTGGAGGGGAAGGCTAGTCATAGAGAGATGACATCTAAGCTTCTTTCTGACCTTTGTGGGACAGTAATGAG
CACAACTGATGTGGAAAAATCATTTGATAAATTGTTGAAAGATCTACCTGAATTAGCACTGGATACTCCTAGAGCACCACAGTTGGTGGG
CCAGTTTATTGCTAGAGCTGTTGGAGATGGAATTTTATGTAATACCTATATTGATAGTTACAAAGGAACTGTAGATTGTGTGCAGGCTAG
AGCTGCTCTGGATAAGGCTACCGTGCTTCTGAGTATGTCTAAAGGTGGAAAGCGTAAAGATAGTGTGTGGGGCTCTGGAGGTGGGCAGCA
ATCTGTCAATCACCTTGTTAAAGAGATTGATATGCTGCTGAAAGAATATTTACTCTCTGGAGACATATCTGAAGCTGAACATTGCCTTAA
GGAACTGGAAGTACCTCATTTTCACCATGAGCTTGTATATGAAGCTATTATAATGGTTTTAGAGTCAACTGGAGAAAGTACATTTAAGAT
GATTTTGGATTTATTAAAGTCCCTTTGGAAGTCTTCTACCATTACTGTAGACCAAATGAAAAGAGGTTATGAGAGAATTTACAATGAAAT
TCCGGACATTAATCTGGATGTCCCACATTCATACTCTGTGCTGGAGCGGTTTGTAGAAGAATGTTTTCAGGCTGGAATAATTTCCAAACA
ACTCAGAGATCTTTGTCCTTCAAGGGGCAGAAAGCGTTTTGTAAGCGAAGGAGATGGAGGTCGTCTTAAACCAGAGAGCTACTGAATATA
AGAACTCTTGCAGTCTTAGATGTTATAAAAATATATATCTGAATTGTAAGAGTTGTTAGCACAAGTTTTTTTTTTTTTTTTTTTTAAGCA
CTTGTTTTGGGTACAAGGCATTTCTGACATTTTATAAACCTACATTTAAGGGGAATTTTTAAAGGAAATGTTTTTTCTTTTTTTTTTGTT
TTTCGAGGGGGCAAGGAGGGACAGAAAAGTAACCTCTTCTTAAGTGGAATATTCTAATAAGCTACCTTTTGTAAGTGCCATGTTTATTAT
CTAATCATTCCAAGTTTTGCATTGATGTCTGACTGCCACTCCTTTCTTTCAAGGACAGTGTTTTTTGTAGTAAAATCACTGGTTTATACA
AAGCTTTATTTAGGGGGTAAAGTTAAGCTGCTAAAACCCCATGTTGGCTGCTGCTGTTGAGATACTGTGCTTTGGGAGTAAAAAAAGAAA
GTTATTTCTTTGTCTTAAAGAATTTTTAAAAAATTAGTCATGAGACTTATTCATCTTTCCAGGGAACATACTGATTGGTCTTAAAAGACT
AGACAGTTAAGTAAAAGGTGGCTGGAACATCTATTTTTCTACAAAACTGGAAAAATGAACCTGGTTCTAGAAGAATGTACACCAAAATAA
AACATGTGAAGCAGTATTGATTCTTTATTGGGAGTACATTTTTTTAGGTCTCTTAAACTTTAATTTCACACAGTAAATTTTGAATCTCAT
AAGGAAGCATATTTGAACCTAGTCAATTTAATCTTAGTGTTCCCTTGAAAACTTTTTTTCCCTACAAAATTTTAAGTGAAAAATACAATA
GTAAATTAAGATTACACTGGGGAAAAAAATGCAGGTATCACTTTACTCCATTGTTATCTGACCTAGAGCTTAATTAAGTTTTAGAAATAT
GTAATACCTTCCATCATTCCATCATCCTTAAATTCTGTTACCAAATAATGGCTAATGTTACAAAAAGTTATACTCCAGAGACCCAAAGCT
TGACATTTACCTAATGTATGAGAAAATATTACCAATTAACAATAAAGAATGATCATATTTTTAACCTCTTTTACATAGCCTAATAACTCA
GCAAGGCCTCAACGTCTGTGCTAATTTAAACTGCCAAATATTGACTGCAGCAAACAAGAATTATATTCAGAATTTATGAGGGTACTGTTA
GGAGTATACTGCTTACAGGTTTAGATATAGTCTGTTAGAATTAAAACCAAGTTTAGTGTTCATATTTACCTCATGGGCTTTATCAAGCCC
ATATTACCTCAGCTTATATATAGTTACCATTTTTAGGTTTTTAATTGTTTGACACTTGGATGATAAATGCAGTCATTTTATTCTCAAGTG
CTTAAAATTAATGTAATTAAAAGCTTAGCTGACTACAGAATAGGTGAGGGTTTCTTAAAAATGAGATTTAAGGGCTGGGCACGGTGGCTC
ATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGCGGATCACTTGAGGTTGGGAGTTCATGACCAGCTTGACCAACATGAAGAAAC
CCTGTCTCTATTAAAAATACAAAAGTAGCCAGGCATGGTGGCGCATGCGTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATTGC
TTGAACCTGGGAGGCAGAGGTTGCAGTGAGTCGAGATGGTGCCATTGCTCTCGTTTGGGCAACAAGAGTGAAACTCTTGTCTCAAAAAAA
AAAAAAAATGAGGTTTAAGACAGTTTTGTCATTACTGGTGGGATCTGGTCACACAAGATAGCATTAAACGTGACATGGCACATAAAATTG
GTTAAAAAATTTTGTTTTTTAATTACGTAATGTAAAAGCCCAACAAACACTTTATGCAAGATTGGAATGTATCTTCAAATTCAGATTTAA

>66338_66338_4_PLEKHS1-PDCD4_PLEKHS1_chr10_115529659_ENST00000369310_PDCD4_chr10_112645011_ENST00000393104_length(amino acids)=500AA_BP=177
MAGGKQFTFSYENEVCKQDYFIKSPPSQLFSSVTSWKKRFFILSKAGEKSFSLSYYKDHHHRGSIEIDQNSSVEVGISSQEKMQSVQKMF
KCHPDEVMSIRTTNREYFLIGHDREKIKDWVSFMSSFRQDIKATQQNTEEELSLGNKRTLFYSSPLLGPSSTSEAVGSSSPRNGLQDKEN
CVYETVVLPLDERAFEKTLTPIIQEYFEHGDTNEVAEMLRDLNLGEMKSGVPVLAVSLALEGKASHREMTSKLLSDLCGTVMSTTDVEKS
FDKLLKDLPELALDTPRAPQLVGQFIARAVGDGILCNTYIDSYKGTVDCVQARAALDKATVLLSMSKGGKRKDSVWGSGGGQQSVNHLVK
EIDMLLKEYLLSGDISEAEHCLKELEVPHFHHELVYEAIIMVLESTGESTFKMILDLLKSLWKSSTITVDQMKRGYERIYNEIPDINLDV

--------------------------------------------------------------
>66338_66338_5_PLEKHS1-PDCD4_PLEKHS1_chr10_115529659_ENST00000369312_PDCD4_chr10_112645011_ENST00000280154_length(transcript)=3638nt_BP=751nt
AGAGTCAGCAGGAGTGAGTTCAGGAATCCTCGGGACAAGGCACTTTCCTGAGCACTGGACCAGCGACCTCTTGGCTTCCAGGGAGGACAC
ACAGCCATCATGGAACCCAAACCTCAGAAGAGTCCAGGTACCCGAGGGGTATAATCGCAGAAGCAGAAATCTTTTTATTGAAAATGCCCC
ACGGTTTCCTTCAAGCTAACCAGGATACAGAACTTGGTGGTTTTTGTGCAAACAATTTACATTTTCTTATGAAAATGAAGTCTGCAAACA
AGATTACTTTATTAAATCACCACCTTCTCAGCTGTTCTCCTCTGTGACCTCTTGGAAAAAGCGGTTTTTCATCCTGTCAAAGGCTGGGGA
AAAGAGCTTTAGTCTTTCCTATTATAAAGACCATCATCACCGAGGTTCCATTGAAATTGATCAAAATTCCAGTGTAGAAGTTGGCATAAG
TAGCCAGGAAAAGATGCAATCTGTGCAGAAGATGTTTAAATGCCACCCTGATGAGGTCATGTCCATCAGAACCACTAACAGGGAATACTT
CCTCATTGGCCACGACAGGGAGAAGATTAAAGACTGGGTCTCCTTCATGTCATCATTTCGCCAGGATATAAAAGCAACACAGCAGAACAC
AGAGGAGGAACTCTCATTGGGTAATAAAAGAACCCTCTTCTACTCCAGCCCTCTCCTTGGCCCTTCCAGCACATCAGAGGCTGTTGGCTC
CAGCTCACCAAGAAATGGTCTCCAAGACAAGGAGAACTGTGTTTATGAAACTGTAGTTTTGCCTTTGGATGAAAGGGCATTTGAGAAGAC
TTTAACACCAATCATACAGGAATATTTTGAGCATGGAGATACTAATGAAGTTGCGGAAATGTTAAGAGATTTAAATCTTGGTGAAATGAA
AAGTGGAGTACCAGTGTTGGCAGTATCCTTAGCATTGGAGGGGAAGGCTAGTCATAGAGAGATGACATCTAAGCTTCTTTCTGACCTTTG
TGGGACAGTAATGAGCACAACTGATGTGGAAAAATCATTTGATAAATTGTTGAAAGATCTACCTGAATTAGCACTGGATACTCCTAGAGC
ACCACAGTTGGTGGGCCAGTTTATTGCTAGAGCTGTTGGAGATGGAATTTTATGTAATACCTATATTGATAGTTACAAAGGAACTGTAGA
TTGTGTGCAGGCTAGAGCTGCTCTGGATAAGGCTACCGTGCTTCTGAGTATGTCTAAAGGTGGAAAGCGTAAAGATAGTGTGTGGGGCTC
TGGAGGTGGGCAGCAATCTGTCAATCACCTTGTTAAAGAGATTGATATGCTGCTGAAAGAATATTTACTCTCTGGAGACATATCTGAAGC
TGAACATTGCCTTAAGGAACTGGAAGTACCTCATTTTCACCATGAGCTTGTATATGAAGCTATTATAATGGTTTTAGAGTCAACTGGAGA
AAGTACATTTAAGATGATTTTGGATTTATTAAAGTCCCTTTGGAAGTCTTCTACCATTACTGTAGACCAAATGAAAAGAGGTTATGAGAG
AATTTACAATGAAATTCCGGACATTAATCTGGATGTCCCACATTCATACTCTGTGCTGGAGCGGTTTGTAGAAGAATGTTTTCAGGCTGG
AATAATTTCCAAACAACTCAGAGATCTTTGTCCTTCAAGGGGCAGAAAGCGTTTTGTAAGCGAAGGAGATGGAGGTCGTCTTAAACCAGA
GAGCTACTGAATATAAGAACTCTTGCAGTCTTAGATGTTATAAAAATATATATCTGAATTGTAAGAGTTGTTAGCACAAGTTTTTTTTTT
TTTTTTTTTTAAGCACTTGTTTTGGGTACAAGGCATTTCTGACATTTTATAAACCTACATTTAAGGGGAATTTTTAAAGGAAATGTTTTT
TCTTTTTTTTTTGTTTTTCGAGGGGGCAAGGAGGGACAGAAAAGTAACCTCTTCTTAAGTGGAATATTCTAATAAGCTACCTTTTGTAAG
TGCCATGTTTATTATCTAATCATTCCAAGTTTTGCATTGATGTCTGACTGCCACTCCTTTCTTTCAAGGACAGTGTTTTTTGTAGTAAAA
TCACTGGTTTATACAAAGCTTTATTTAGGGGGTAAAGTTAAGCTGCTAAAACCCCATGTTGGCTGCTGCTGTTGAGATACTGTGCTTTGG
GAGTAAAAAAAGAAAGTTATTTCTTTGTCTTAAAGAATTTTTAAAAAATTAGTCATGAGACTTATTCATCTTTCCAGGGAACATACTGAT
TGGTCTTAAAAGACTAGACAGTTAAGTAAAAGGTGGCTGGAACATCTATTTTTCTACAAAACTGGAAAAATGAACCTGGTTCTAGAAGAA
TGTACACCAAAATAAAACATGTGAAGCAGTATTGATTCTTTATTGGGAGTACATTTTTTTAGGTCTCTTAAACTTTAATTTCACACAGTA
AATTTTGAATCTCATAAGGAAGCATATTTGAACCTAGTCAATTTAATCTTAGTGTTCCCTTGAAAACTTTTTTTCCCTACAAAATTTTAA
GTGAAAAATACAATAGTAAATTAAGATTACACTGGGGAAAAAAATGCAGGTATCACTTTACTCCATTGTTATCTGACCTAGAGCTTAATT
AAGTTTTAGAAATATGTAATACCTTCCATCATTCCATCATCCTTAAATTCTGTTACCAAATAATGGCTAATGTTACAAAAAGTTATACTC
CAGAGACCCAAAGCTTGACATTTACCTAATGTATGAGAAAATATTACCAATTAACAATAAAGAATGATCATATTTTTAACCTCTTTTACA
TAGCCTAATAACTCAGCAAGGCCTCAACGTCTGTGCTAATTTAAACTGCCAAATATTGACTGCAGCAAACAAGAATTATATTCAGAATTT
ATGAGGGTACTGTTAGGAGTATACTGCTTACAGGTTTAGATATAGTCTGTTAGAATTAAAACCAAGTTTAGTGTTCATATTTACCTCATG
GGCTTTATCAAGCCCATATTACCTCAGCTTATATATAGTTACCATTTTTAGGTTTTTAATTGTTTGACACTTGGATGATAAATGCAGTCA
TTTTATTCTCAAGTGCTTAAAATTAATGTAATTAAAAGCTTAGCTGACTACAGAATAGGTGAGGGTTTCTTAAAAATGAGATTTAAGGGC
TGGGCACGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGCGGATCACTTGAGGTTGGGAGTTCATGACCAGCTTGA
CCAACATGAAGAAACCCTGTCTCTATTAAAAATACAAAAGTAGCCAGGCATGGTGGCGCATGCGTGTAATCCCAGCTACTTGGGAGGCTG
AGGCAGGAGAATTGCTTGAACCTGGGAGGCAGAGGTTGCAGTGAGTCGAGATGGTGCCATTGCTCTCGTTTGGGCAACAAGAGTGAAACT
CTTGTCTCAAAAAAAAAAAAAAATGAGGTTTAAGACAGTTTTGTCATTACTGGTGGGATCTGGTCACACAAGATAGCATTAAACGTGACA
TGGCACATAAAATTGGTTAAAAAATTTTGTTTTTTAATTACGTAATGTAAAAGCCCAACAAACACTTTATGCAAGATTGGAATGTATCTT

>66338_66338_5_PLEKHS1-PDCD4_PLEKHS1_chr10_115529659_ENST00000369312_PDCD4_chr10_112645011_ENST00000280154_length(amino acids)=498AA_BP=175
MCKQFTFSYENEVCKQDYFIKSPPSQLFSSVTSWKKRFFILSKAGEKSFSLSYYKDHHHRGSIEIDQNSSVEVGISSQEKMQSVQKMFKC
HPDEVMSIRTTNREYFLIGHDREKIKDWVSFMSSFRQDIKATQQNTEEELSLGNKRTLFYSSPLLGPSSTSEAVGSSSPRNGLQDKENCV
YETVVLPLDERAFEKTLTPIIQEYFEHGDTNEVAEMLRDLNLGEMKSGVPVLAVSLALEGKASHREMTSKLLSDLCGTVMSTTDVEKSFD
KLLKDLPELALDTPRAPQLVGQFIARAVGDGILCNTYIDSYKGTVDCVQARAALDKATVLLSMSKGGKRKDSVWGSGGGQQSVNHLVKEI
DMLLKEYLLSGDISEAEHCLKELEVPHFHHELVYEAIIMVLESTGESTFKMILDLLKSLWKSSTITVDQMKRGYERIYNEIPDINLDVPH

--------------------------------------------------------------
>66338_66338_6_PLEKHS1-PDCD4_PLEKHS1_chr10_115529659_ENST00000369312_PDCD4_chr10_112645011_ENST00000393104_length(transcript)=3637nt_BP=751nt
AGAGTCAGCAGGAGTGAGTTCAGGAATCCTCGGGACAAGGCACTTTCCTGAGCACTGGACCAGCGACCTCTTGGCTTCCAGGGAGGACAC
ACAGCCATCATGGAACCCAAACCTCAGAAGAGTCCAGGTACCCGAGGGGTATAATCGCAGAAGCAGAAATCTTTTTATTGAAAATGCCCC
ACGGTTTCCTTCAAGCTAACCAGGATACAGAACTTGGTGGTTTTTGTGCAAACAATTTACATTTTCTTATGAAAATGAAGTCTGCAAACA
AGATTACTTTATTAAATCACCACCTTCTCAGCTGTTCTCCTCTGTGACCTCTTGGAAAAAGCGGTTTTTCATCCTGTCAAAGGCTGGGGA
AAAGAGCTTTAGTCTTTCCTATTATAAAGACCATCATCACCGAGGTTCCATTGAAATTGATCAAAATTCCAGTGTAGAAGTTGGCATAAG
TAGCCAGGAAAAGATGCAATCTGTGCAGAAGATGTTTAAATGCCACCCTGATGAGGTCATGTCCATCAGAACCACTAACAGGGAATACTT
CCTCATTGGCCACGACAGGGAGAAGATTAAAGACTGGGTCTCCTTCATGTCATCATTTCGCCAGGATATAAAAGCAACACAGCAGAACAC
AGAGGAGGAACTCTCATTGGGTAATAAAAGAACCCTCTTCTACTCCAGCCCTCTCCTTGGCCCTTCCAGCACATCAGAGGCTGTTGGCTC
CAGCTCACCAAGAAATGGTCTCCAAGACAAGGAGAACTGTGTTTATGAAACTGTAGTTTTGCCTTTGGATGAAAGGGCATTTGAGAAGAC
TTTAACACCAATCATACAGGAATATTTTGAGCATGGAGATACTAATGAAGTTGCGGAAATGTTAAGAGATTTAAATCTTGGTGAAATGAA
AAGTGGAGTACCAGTGTTGGCAGTATCCTTAGCATTGGAGGGGAAGGCTAGTCATAGAGAGATGACATCTAAGCTTCTTTCTGACCTTTG
TGGGACAGTAATGAGCACAACTGATGTGGAAAAATCATTTGATAAATTGTTGAAAGATCTACCTGAATTAGCACTGGATACTCCTAGAGC
ACCACAGTTGGTGGGCCAGTTTATTGCTAGAGCTGTTGGAGATGGAATTTTATGTAATACCTATATTGATAGTTACAAAGGAACTGTAGA
TTGTGTGCAGGCTAGAGCTGCTCTGGATAAGGCTACCGTGCTTCTGAGTATGTCTAAAGGTGGAAAGCGTAAAGATAGTGTGTGGGGCTC
TGGAGGTGGGCAGCAATCTGTCAATCACCTTGTTAAAGAGATTGATATGCTGCTGAAAGAATATTTACTCTCTGGAGACATATCTGAAGC
TGAACATTGCCTTAAGGAACTGGAAGTACCTCATTTTCACCATGAGCTTGTATATGAAGCTATTATAATGGTTTTAGAGTCAACTGGAGA
AAGTACATTTAAGATGATTTTGGATTTATTAAAGTCCCTTTGGAAGTCTTCTACCATTACTGTAGACCAAATGAAAAGAGGTTATGAGAG
AATTTACAATGAAATTCCGGACATTAATCTGGATGTCCCACATTCATACTCTGTGCTGGAGCGGTTTGTAGAAGAATGTTTTCAGGCTGG
AATAATTTCCAAACAACTCAGAGATCTTTGTCCTTCAAGGGGCAGAAAGCGTTTTGTAAGCGAAGGAGATGGAGGTCGTCTTAAACCAGA
GAGCTACTGAATATAAGAACTCTTGCAGTCTTAGATGTTATAAAAATATATATCTGAATTGTAAGAGTTGTTAGCACAAGTTTTTTTTTT
TTTTTTTTTTAAGCACTTGTTTTGGGTACAAGGCATTTCTGACATTTTATAAACCTACATTTAAGGGGAATTTTTAAAGGAAATGTTTTT
TCTTTTTTTTTTGTTTTTCGAGGGGGCAAGGAGGGACAGAAAAGTAACCTCTTCTTAAGTGGAATATTCTAATAAGCTACCTTTTGTAAG
TGCCATGTTTATTATCTAATCATTCCAAGTTTTGCATTGATGTCTGACTGCCACTCCTTTCTTTCAAGGACAGTGTTTTTTGTAGTAAAA
TCACTGGTTTATACAAAGCTTTATTTAGGGGGTAAAGTTAAGCTGCTAAAACCCCATGTTGGCTGCTGCTGTTGAGATACTGTGCTTTGG
GAGTAAAAAAAGAAAGTTATTTCTTTGTCTTAAAGAATTTTTAAAAAATTAGTCATGAGACTTATTCATCTTTCCAGGGAACATACTGAT
TGGTCTTAAAAGACTAGACAGTTAAGTAAAAGGTGGCTGGAACATCTATTTTTCTACAAAACTGGAAAAATGAACCTGGTTCTAGAAGAA
TGTACACCAAAATAAAACATGTGAAGCAGTATTGATTCTTTATTGGGAGTACATTTTTTTAGGTCTCTTAAACTTTAATTTCACACAGTA
AATTTTGAATCTCATAAGGAAGCATATTTGAACCTAGTCAATTTAATCTTAGTGTTCCCTTGAAAACTTTTTTTCCCTACAAAATTTTAA
GTGAAAAATACAATAGTAAATTAAGATTACACTGGGGAAAAAAATGCAGGTATCACTTTACTCCATTGTTATCTGACCTAGAGCTTAATT
AAGTTTTAGAAATATGTAATACCTTCCATCATTCCATCATCCTTAAATTCTGTTACCAAATAATGGCTAATGTTACAAAAAGTTATACTC
CAGAGACCCAAAGCTTGACATTTACCTAATGTATGAGAAAATATTACCAATTAACAATAAAGAATGATCATATTTTTAACCTCTTTTACA
TAGCCTAATAACTCAGCAAGGCCTCAACGTCTGTGCTAATTTAAACTGCCAAATATTGACTGCAGCAAACAAGAATTATATTCAGAATTT
ATGAGGGTACTGTTAGGAGTATACTGCTTACAGGTTTAGATATAGTCTGTTAGAATTAAAACCAAGTTTAGTGTTCATATTTACCTCATG
GGCTTTATCAAGCCCATATTACCTCAGCTTATATATAGTTACCATTTTTAGGTTTTTAATTGTTTGACACTTGGATGATAAATGCAGTCA
TTTTATTCTCAAGTGCTTAAAATTAATGTAATTAAAAGCTTAGCTGACTACAGAATAGGTGAGGGTTTCTTAAAAATGAGATTTAAGGGC
TGGGCACGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGCGGATCACTTGAGGTTGGGAGTTCATGACCAGCTTGA
CCAACATGAAGAAACCCTGTCTCTATTAAAAATACAAAAGTAGCCAGGCATGGTGGCGCATGCGTGTAATCCCAGCTACTTGGGAGGCTG
AGGCAGGAGAATTGCTTGAACCTGGGAGGCAGAGGTTGCAGTGAGTCGAGATGGTGCCATTGCTCTCGTTTGGGCAACAAGAGTGAAACT
CTTGTCTCAAAAAAAAAAAAAAATGAGGTTTAAGACAGTTTTGTCATTACTGGTGGGATCTGGTCACACAAGATAGCATTAAACGTGACA
TGGCACATAAAATTGGTTAAAAAATTTTGTTTTTTAATTACGTAATGTAAAAGCCCAACAAACACTTTATGCAAGATTGGAATGTATCTT

>66338_66338_6_PLEKHS1-PDCD4_PLEKHS1_chr10_115529659_ENST00000369312_PDCD4_chr10_112645011_ENST00000393104_length(amino acids)=498AA_BP=175
MCKQFTFSYENEVCKQDYFIKSPPSQLFSSVTSWKKRFFILSKAGEKSFSLSYYKDHHHRGSIEIDQNSSVEVGISSQEKMQSVQKMFKC
HPDEVMSIRTTNREYFLIGHDREKIKDWVSFMSSFRQDIKATQQNTEEELSLGNKRTLFYSSPLLGPSSTSEAVGSSSPRNGLQDKENCV
YETVVLPLDERAFEKTLTPIIQEYFEHGDTNEVAEMLRDLNLGEMKSGVPVLAVSLALEGKASHREMTSKLLSDLCGTVMSTTDVEKSFD
KLLKDLPELALDTPRAPQLVGQFIARAVGDGILCNTYIDSYKGTVDCVQARAALDKATVLLSMSKGGKRKDSVWGSGGGQQSVNHLVKEI
DMLLKEYLLSGDISEAEHCLKELEVPHFHHELVYEAIIMVLESTGESTFKMILDLLKSLWKSSTITVDQMKRGYERIYNEIPDINLDVPH

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for PLEKHS1-PDCD4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for PLEKHS1-PDCD4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for PLEKHS1-PDCD4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource