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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PLSCR1-MACROD2 (FusionGDB2 ID:66474)

Fusion Gene Summary for PLSCR1-MACROD2

check button Fusion gene summary
Fusion gene informationFusion gene name: PLSCR1-MACROD2
Fusion gene ID: 66474
HgeneTgene
Gene symbol

PLSCR1

MACROD2

Gene ID

5359

140733

Gene namephospholipid scramblase 1mono-ADP ribosylhydrolase 2
SynonymsMMTRA1BC20orf133|C2orf133
Cytomap

3q24

20p12.1

Type of geneprotein-codingprotein-coding
Descriptionphospholipid scramblase 1PL scramblase 1ca(2+)-dependent phospholipid scramblase 1erythrocyte phospholipid scramblaseADP-ribose glycohydrolase MACROD2MACRO domain containing 2MACRO domain-containing protein 2O-acetyl-ADP-ribose deacetylase MACROD2[Protein ADP-ribosylaspartate] hydrolase MACROD2[Protein ADP-ribosylglutamate] hydrolase[Protein ADP-ribosylglutamate]
Modification date2020031320200313
UniProtAcc.

A1Z1Q3

Ensembl transtripts involved in fusion geneENST00000342435, ENST00000448205, 
ENST00000448787, ENST00000487389, 
ENST00000484560, 		ENST00000378058, 
ENST00000402914, ENST00000407045, 
ENST00000464883, ENST00000217246, 
ENST00000310348, 
Fusion gene scores* DoF score5 X 5 X 3=7537 X 34 X 11=13838
# samples 641
** MAII scorelog2(6/75*10)=-0.321928094887362
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(41/13838*10)=-5.07686772601114
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PLSCR1 [Title/Abstract] AND MACROD2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPLSCR1(146234793)-MACROD2(16021846), # samples:3
Anticipated loss of major functional domain due to fusion event.PLSCR1-MACROD2 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePLSCR1

GO:0006915

apoptotic process

10770950

HgenePLSCR1

GO:0017121

phospholipid scrambling

9218461|10770950|18629440

HgenePLSCR1

GO:0045944

positive regulation of transcription by RNA polymerase II

16091359

HgenePLSCR1

GO:2000373

positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity

17567603

TgeneMACROD2

GO:0042278

purine nucleoside metabolic process

21257746

TgeneMACROD2

GO:0051725

protein de-ADP-ribosylation

23474712


check buttonFusion gene breakpoints across PLSCR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MACROD2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-QK-A6V9-01APLSCR1chr3

146234793

-MACROD2chr20

16021846

+
ChimerDB4HNSCTCGA-QK-A6V9PLSCR1chr3

146166993

-MACROD2chr20

16021846

+
ChimerDB4HNSCTCGA-QK-A6V9PLSCR1chr3

146234793

-MACROD2chr20

16021846

+


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Fusion Gene ORF analysis for PLSCR1-MACROD2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000342435ENST00000378058PLSCR1chr3

146234793

-MACROD2chr20

16021846

+
5CDS-intronENST00000342435ENST00000402914PLSCR1chr3

146234793

-MACROD2chr20

16021846

+
5CDS-intronENST00000342435ENST00000407045PLSCR1chr3

146234793

-MACROD2chr20

16021846

+
5CDS-intronENST00000342435ENST00000464883PLSCR1chr3

146234793

-MACROD2chr20

16021846

+
5CDS-intronENST00000448205ENST00000378058PLSCR1chr3

146234793

-MACROD2chr20

16021846

+
5CDS-intronENST00000448205ENST00000402914PLSCR1chr3

146234793

-MACROD2chr20

16021846

+
5CDS-intronENST00000448205ENST00000407045PLSCR1chr3

146234793

-MACROD2chr20

16021846

+
5CDS-intronENST00000448205ENST00000464883PLSCR1chr3

146234793

-MACROD2chr20

16021846

+
5CDS-intronENST00000448787ENST00000378058PLSCR1chr3

146234793

-MACROD2chr20

16021846

+
5CDS-intronENST00000448787ENST00000402914PLSCR1chr3

146234793

-MACROD2chr20

16021846

+
5CDS-intronENST00000448787ENST00000407045PLSCR1chr3

146234793

-MACROD2chr20

16021846

+
5CDS-intronENST00000448787ENST00000464883PLSCR1chr3

146234793

-MACROD2chr20

16021846

+
5CDS-intronENST00000487389ENST00000378058PLSCR1chr3

146234793

-MACROD2chr20

16021846

+
5CDS-intronENST00000487389ENST00000402914PLSCR1chr3

146234793

-MACROD2chr20

16021846

+
5CDS-intronENST00000487389ENST00000407045PLSCR1chr3

146234793

-MACROD2chr20

16021846

+
5CDS-intronENST00000487389ENST00000464883PLSCR1chr3

146234793

-MACROD2chr20

16021846

+
Frame-shiftENST00000448787ENST00000217246PLSCR1chr3

146234793

-MACROD2chr20

16021846

+
Frame-shiftENST00000448787ENST00000310348PLSCR1chr3

146234793

-MACROD2chr20

16021846

+
In-frameENST00000342435ENST00000217246PLSCR1chr3

146234793

-MACROD2chr20

16021846

+
In-frameENST00000342435ENST00000310348PLSCR1chr3

146234793

-MACROD2chr20

16021846

+
In-frameENST00000448205ENST00000217246PLSCR1chr3

146234793

-MACROD2chr20

16021846

+
In-frameENST00000448205ENST00000310348PLSCR1chr3

146234793

-MACROD2chr20

16021846

+
In-frameENST00000487389ENST00000217246PLSCR1chr3

146234793

-MACROD2chr20

16021846

+
In-frameENST00000487389ENST00000310348PLSCR1chr3

146234793

-MACROD2chr20

16021846

+
intron-3CDSENST00000342435ENST00000217246PLSCR1chr3

146166993

-MACROD2chr20

16021846

+
intron-3CDSENST00000342435ENST00000310348PLSCR1chr3

146166993

-MACROD2chr20

16021846

+
intron-3CDSENST00000448205ENST00000217246PLSCR1chr3

146166993

-MACROD2chr20

16021846

+
intron-3CDSENST00000448205ENST00000310348PLSCR1chr3

146166993

-MACROD2chr20

16021846

+
intron-3CDSENST00000448787ENST00000217246PLSCR1chr3

146166993

-MACROD2chr20

16021846

+
intron-3CDSENST00000448787ENST00000310348PLSCR1chr3

146166993

-MACROD2chr20

16021846

+
intron-3CDSENST00000484560ENST00000217246PLSCR1chr3

146234793

-MACROD2chr20

16021846

+
intron-3CDSENST00000484560ENST00000217246PLSCR1chr3

146166993

-MACROD2chr20

16021846

+
intron-3CDSENST00000484560ENST00000310348PLSCR1chr3

146234793

-MACROD2chr20

16021846

+
intron-3CDSENST00000484560ENST00000310348PLSCR1chr3

146166993

-MACROD2chr20

16021846

+
intron-3CDSENST00000487389ENST00000217246PLSCR1chr3

146166993

-MACROD2chr20

16021846

+
intron-3CDSENST00000487389ENST00000310348PLSCR1chr3

146166993

-MACROD2chr20

16021846

+
intron-intronENST00000342435ENST00000378058PLSCR1chr3

146166993

-MACROD2chr20

16021846

+
intron-intronENST00000342435ENST00000402914PLSCR1chr3

146166993

-MACROD2chr20

16021846

+
intron-intronENST00000342435ENST00000407045PLSCR1chr3

146166993

-MACROD2chr20

16021846

+
intron-intronENST00000342435ENST00000464883PLSCR1chr3

146166993

-MACROD2chr20

16021846

+
intron-intronENST00000448205ENST00000378058PLSCR1chr3

146166993

-MACROD2chr20

16021846

+
intron-intronENST00000448205ENST00000402914PLSCR1chr3

146166993

-MACROD2chr20

16021846

+
intron-intronENST00000448205ENST00000407045PLSCR1chr3

146166993

-MACROD2chr20

16021846

+
intron-intronENST00000448205ENST00000464883PLSCR1chr3

146166993

-MACROD2chr20

16021846

+
intron-intronENST00000448787ENST00000378058PLSCR1chr3

146166993

-MACROD2chr20

16021846

+
intron-intronENST00000448787ENST00000402914PLSCR1chr3

146166993

-MACROD2chr20

16021846

+
intron-intronENST00000448787ENST00000407045PLSCR1chr3

146166993

-MACROD2chr20

16021846

+
intron-intronENST00000448787ENST00000464883PLSCR1chr3

146166993

-MACROD2chr20

16021846

+
intron-intronENST00000484560ENST00000378058PLSCR1chr3

146234793

-MACROD2chr20

16021846

+
intron-intronENST00000484560ENST00000378058PLSCR1chr3

146166993

-MACROD2chr20

16021846

+
intron-intronENST00000484560ENST00000402914PLSCR1chr3

146234793

-MACROD2chr20

16021846

+
intron-intronENST00000484560ENST00000402914PLSCR1chr3

146166993

-MACROD2chr20

16021846

+
intron-intronENST00000484560ENST00000407045PLSCR1chr3

146234793

-MACROD2chr20

16021846

+
intron-intronENST00000484560ENST00000407045PLSCR1chr3

146166993

-MACROD2chr20

16021846

+
intron-intronENST00000484560ENST00000464883PLSCR1chr3

146234793

-MACROD2chr20

16021846

+
intron-intronENST00000484560ENST00000464883PLSCR1chr3

146166993

-MACROD2chr20

16021846

+
intron-intronENST00000487389ENST00000378058PLSCR1chr3

146166993

-MACROD2chr20

16021846

+
intron-intronENST00000487389ENST00000402914PLSCR1chr3

146166993

-MACROD2chr20

16021846

+
intron-intronENST00000487389ENST00000407045PLSCR1chr3

146166993

-MACROD2chr20

16021846

+
intron-intronENST00000487389ENST00000464883PLSCR1chr3

146166993

-MACROD2chr20

16021846

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000342435PLSCR1chr3146234793-ENST00000217246MACROD2chr2016021846+475713113541367337
ENST00000342435PLSCR1chr3146234793-ENST00000310348MACROD2chr2016021846+150513113541367337
ENST00000448205PLSCR1chr3146234793-ENST00000217246MACROD2chr2016021846+39094637271029100
ENST00000448205PLSCR1chr3146234793-ENST00000310348MACROD2chr2016021846+65746346116299
ENST00000487389PLSCR1chr3146234793-ENST00000217246MACROD2chr2016021846+460411582131214333
ENST00000487389PLSCR1chr3146234793-ENST00000310348MACROD2chr2016021846+135211582131214333

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000342435ENST00000217246PLSCR1chr3146234793-MACROD2chr2016021846+0.0003573730.9996426
ENST00000342435ENST00000310348PLSCR1chr3146234793-MACROD2chr2016021846+0.0008389820.999161
ENST00000448205ENST00000217246PLSCR1chr3146234793-MACROD2chr2016021846+0.57074030.42925978
ENST00000448205ENST00000310348PLSCR1chr3146234793-MACROD2chr2016021846+0.109719010.890281
ENST00000487389ENST00000217246PLSCR1chr3146234793-MACROD2chr2016021846+0.0003275870.9996724
ENST00000487389ENST00000310348PLSCR1chr3146234793-MACROD2chr2016021846+0.000667860.99933213

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Fusion Genomic Features for PLSCR1-MACROD2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PLSCR1chr3146234792-MACROD2chr2016021845+8.09E-050.9999192
PLSCR1chr3146234792-MACROD2chr2016021845+8.09E-050.9999192
PLSCR1chr3146234792-MACROD2chr2016021845+8.09E-050.9999192
PLSCR1chr3146234792-MACROD2chr2016021845+8.09E-050.9999192

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PLSCR1-MACROD2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:146234793/chr20:16021846)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MACROD2

A1Z1Q3

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Removes ADP-ribose from asparatate and glutamate residues in proteins bearing a single ADP-ribose moiety (PubMed:23474714, PubMed:23474712). Inactive towards proteins bearing poly-ADP-ribose (PubMed:23474714, PubMed:23474712). Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins (PubMed:21257746). {ECO:0000269|PubMed:21257746, ECO:0000269|PubMed:23474712, ECO:0000269|PubMed:23474714}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePLSCR1chr3:146234793chr20:16021846ENST00000342435-89181_189300319.0Compositional biasNote=Cys-rich
HgenePLSCR1chr3:146234793chr20:16021846ENST00000342435-8918_26300319.0MotifSH3-binding 1
HgenePLSCR1chr3:146234793chr20:16021846ENST00000342435-8922_25300319.0MotifPPXY motif 1
HgenePLSCR1chr3:146234793chr20:16021846ENST00000342435-89257_266300319.0MotifNuclear localization signal
HgenePLSCR1chr3:146234793chr20:16021846ENST00000342435-8933_36300319.0MotifPPXY motif 2
HgenePLSCR1chr3:146234793chr20:16021846ENST00000342435-8942_50300319.0MotifSH3-binding 2
HgenePLSCR1chr3:146234793chr20:16021846ENST00000342435-8984_92300319.0MotifSH3-binding 3
HgenePLSCR1chr3:146234793chr20:16021846ENST00000342435-891_84300319.0RegionProline-rich domain (PRD)
HgenePLSCR1chr3:146234793chr20:16021846ENST00000342435-891_288300319.0Topological domainCytoplasmic
TgeneMACROD2chr3:146234793chr20:16021846ENST00000378058610247_388149214.0Compositional biasNote=Glu-rich
TgeneMACROD2chr3:146234793chr20:16021846ENST000004029141014247_388149214.0Compositional biasNote=Glu-rich
TgeneMACROD2chr3:146234793chr20:16021846ENST0000040704526247_3883599.0Compositional biasNote=Glu-rich
TgeneMACROD2chr3:146234793chr20:16021846ENST000004070452659_2403599.0DomainMacro
TgeneMACROD2chr3:146234793chr20:16021846ENST00000378058610185_191149214.0RegionSubstrate binding
TgeneMACROD2chr3:146234793chr20:16021846ENST000004029141014185_191149214.0RegionSubstrate binding
TgeneMACROD2chr3:146234793chr20:16021846ENST0000040704526185_1913599.0RegionSubstrate binding
TgeneMACROD2chr3:146234793chr20:16021846ENST000004070452677_793599.0RegionSubstrate binding
TgeneMACROD2chr3:146234793chr20:16021846ENST000004070452690_923599.0RegionSubstrate binding
TgeneMACROD2chr3:146234793chr20:16021846ENST000004070452697_1023599.0RegionSubstrate binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePLSCR1chr3:146234793chr20:16021846ENST00000342435-89306_318300319.0Topological domainExtracellular
HgenePLSCR1chr3:146234793chr20:16021846ENST00000342435-89289_305300319.0TransmembraneHelical
TgeneMACROD2chr3:146234793chr20:16021846ENST000002172461417247_388384426.0Compositional biasNote=Glu-rich
TgeneMACROD2chr3:146234793chr20:16021846ENST0000021724614176_9384426.0Compositional biasNote=Poly-Lys
TgeneMACROD2chr3:146234793chr20:16021846ENST000003103481418247_388384449.0Compositional biasNote=Glu-rich
TgeneMACROD2chr3:146234793chr20:16021846ENST0000031034814186_9384449.0Compositional biasNote=Poly-Lys
TgeneMACROD2chr3:146234793chr20:16021846ENST000003780586106_9149214.0Compositional biasNote=Poly-Lys
TgeneMACROD2chr3:146234793chr20:16021846ENST0000040291410146_9149214.0Compositional biasNote=Poly-Lys
TgeneMACROD2chr3:146234793chr20:16021846ENST00000407045266_93599.0Compositional biasNote=Poly-Lys
TgeneMACROD2chr3:146234793chr20:16021846ENST00000217246141759_240384426.0DomainMacro
TgeneMACROD2chr3:146234793chr20:16021846ENST00000310348141859_240384449.0DomainMacro
TgeneMACROD2chr3:146234793chr20:16021846ENST0000037805861059_240149214.0DomainMacro
TgeneMACROD2chr3:146234793chr20:16021846ENST00000402914101459_240149214.0DomainMacro
TgeneMACROD2chr3:146234793chr20:16021846ENST000002172461417185_191384426.0RegionSubstrate binding
TgeneMACROD2chr3:146234793chr20:16021846ENST00000217246141777_79384426.0RegionSubstrate binding
TgeneMACROD2chr3:146234793chr20:16021846ENST00000217246141790_92384426.0RegionSubstrate binding
TgeneMACROD2chr3:146234793chr20:16021846ENST00000217246141797_102384426.0RegionSubstrate binding
TgeneMACROD2chr3:146234793chr20:16021846ENST000003103481418185_191384449.0RegionSubstrate binding
TgeneMACROD2chr3:146234793chr20:16021846ENST00000310348141877_79384449.0RegionSubstrate binding
TgeneMACROD2chr3:146234793chr20:16021846ENST00000310348141890_92384449.0RegionSubstrate binding
TgeneMACROD2chr3:146234793chr20:16021846ENST00000310348141897_102384449.0RegionSubstrate binding
TgeneMACROD2chr3:146234793chr20:16021846ENST0000037805861077_79149214.0RegionSubstrate binding
TgeneMACROD2chr3:146234793chr20:16021846ENST0000037805861090_92149214.0RegionSubstrate binding
TgeneMACROD2chr3:146234793chr20:16021846ENST0000037805861097_102149214.0RegionSubstrate binding
TgeneMACROD2chr3:146234793chr20:16021846ENST00000402914101477_79149214.0RegionSubstrate binding
TgeneMACROD2chr3:146234793chr20:16021846ENST00000402914101490_92149214.0RegionSubstrate binding
TgeneMACROD2chr3:146234793chr20:16021846ENST00000402914101497_102149214.0RegionSubstrate binding


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Fusion Gene Sequence for PLSCR1-MACROD2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>66474_66474_1_PLSCR1-MACROD2_PLSCR1_chr3_146234793_ENST00000342435_MACROD2_chr20_16021846_ENST00000217246_length(transcript)=4757nt_BP=1311nt
GAGTCCCAGTTCCTCTCCTTAACCACCGGACAAACGTCTCTGGAGTCTCTCCAATGAGCAAGAAAGCAAGTCGGGGGTAGGGGAGGGGCC
TCACACCAGGGGGTGGGCGCAGTCCCTCCTCCAGCTCCTTCACCCTCCAGTAGTCTCGTGGGTCCCCGAGCGCCAGCGCGGGAACCGGGA
AAAGGAAACCGTGTTGTGTACGTAAGATTCAGGAAACGAAACCAGGAGCCGCGGGTGTTGGCGCAAAGGTTACTCCCAGACCCTTTTCCG
GCTGACTTCTGAGAAGGTTGCGCAGCAGCTGTGCCCGGCAGTCTAGAGGCGCAGAAGAGGAAGCCATCGCCTGGCCCCGGCTCTCTGGAC
CTTGTCTCGCTCGGGAGCGGAAACAGCGGCAGCCAGAGAACTGTTTTAATCATGGACAAACAAAACTCACAGATGAATGCTTCTCACCCG
GAAACAAACTTGCCAGTTGGGTATCCTCCTCAGTATCCACCGACAGCATTCCAAGGACCTCCAGGATATAGTGGCTACCCTGGGCCCCAG
GTCAGCTACCCACCCCCACCAGCCGGCCATTCAGGTCCTGGCCCAGCTGGCTTTCCTGTCCCAAATCAGCCAGTGTATAATCAGCCAGTA
TATAATCAGCCAGTTGGAGCTGCAGGGGTACCATGGATGCCAGCGCCACAGCCTCCATTAAACTGTCCACCTGGATTAGAATATTTAAGT
CAGATAGATCAGATACTGATTCATCAGCAAATTGAACTTCTGGAAGTTTTAACAGGTTTTGAAACTAATAACAAATATGAAATTAAGAAC
AGCTTTGGACAGAGGGTTTACTTTGCAGCGGAAGATACTGATTGCTGTACCCGAAATTGCTGTGGGCCATCTAGACCTTTTACCTTGAGG
ATTATTGATAATATGGGTCAAGAAGTCATAACTCTGGAGAGACCACTAAGATGTAGCAGCTGTTGTTGTCCCTGCTGCCTTCAGGAGATA
GAAATCCAAGCTCCTCCTGGTGTACCAATAGGTTATGTTATTCAGACTTGGCACCCATGTCTACCAAAGTTTACAATTCAAAATGAGAAA
AGAGAGGATGTACTAAAAATAAGTGGTCCATGTGTTGTGTGCAGCTGTTGTGGAGATGTTGATTTTGAGATTAAATCTCTTGATGAACAG
TGTGTGGTTGGCAAAATTTCCAAGCACTGGACTGGAATTTTGAGAGAGGCATTTACAGACGCTGATAACTTTGGAATCCAGTTCCCTTTA
GACCTTGATGTTAAAATGAAAGCTGTAATGATTGGTGCCTGTTTCCTCATTCTCCAGGCGAGGACACACCTAGGATGCCTGGGAAAAGTG
AAGGCTCCAGTGACCTAGAAAATACTCCAGGTCCTGATGCAGGGGCACAAGATGAAGCGAAGGAACAAAGAAATGGAACTAAATGACAAT
CCTCAGCATCGCAAGGCCTCTCCTGGCTCTGGGGGAGCTCGGGAAGATAGCAGCACACGCTGTGGAGGAGGGTGGGGGTGGGGGGAAGGC
AAGTCCCATGGAAGGACGGGGAATCCTTTACTCTAATTTCTCCAGCTGCATTTTGTTCCGTTTATCTGCAGAAAAAGAAAGAAAAAAAAG
AAAAAAAAAGTTTCCTTTAATTTGGTGGAGGGACCCATGTTGACGCATCTTTCAGGCATTATCCTTGTAATTTCTGTCTTTTCTCTTACA
ACTTTGCCCCAGGGTCACAGTGGCTTGATTGAACACTCACATGTGTATCCTGGCCCCTGTCTGCTTTCTTGGTTATTTCACAAAGCTGGT
CACACAGTGGTTTATTCAAAGGAAGGGGAGGAAGACAGTGGTTTGATAAGCTGCAGGATAAATTTTAGGAATCAATGAGCCCAGCAGCAG
TATAATCCCCAGACAGAGGAGGCAGGATAGAAAATGGGCAAAAGCCTCGGAAACCACTTGGAAAAGGTCTGGACAATGAGGTGAAAATAT
TTTCTTCAGGGTTCCCAAGGCACAATTTGTTCCAAGTGGCTAATGAGAAATATGGAAGCTGAATTTTTTCCAGAGCAGAGTGCAGAGGCA
TAACAGAAGGGTGGGCCCTGGCAGCCATCTGGGTCTCTTCCTTCCTAACCATGGTGGCAGGTGCATCCTTCTTTGACACTGACTTTCAGC
AGAGCTTACTTGGTTCATGAGGTCTTCACATGGAGACTACCAGCAAGAGGTGACTCTCTGCTGCATAACTGTAAAGGATGGCCCTTTGCT
AGGTGTTACAGTTAAAAGCTAAGAAAAGGGGCAGTGCATTTAGGACCCAAACATATGCCTATGAATATCAAAAGCTCCTCCTGAAATTGC
TGTGAGTTTTCCATAAAAGAATATCCTGTCTTCACCCAAGGCTTGACAGCCCACAGAGTGGTCTCATTTGAAATTACAGGAAATTAGAGC
TTTTGCTTGCAGTTCTGCCTTCCTGGCCTGTGTTTAAATGCTGTCACTTGTTTATGCCAAGTTCAAGGCTGATTCAATGGTTGGTCCCCT
CACCCAGAAAACCCTGAAGGGGAGGATACAGCTCTGAAGGGGGGCAGCAGTACTAAAAACCCAAGATGCCAGTGGTATAGTGGGCACAAG
GGATGGCGACCATGAGGATGCCAGGCATCATCACCAATATCTATCCTAGAGCCAGTATAAGGCCAGATGCCTACTTCCCACAGCCTCCCC
GGGTTCCAAAGTCATGTCATTGTTTTCAGTGGAAACATATCGTTTGTTGCATATCTTCTTAAATCCATCTTCCTTGTAAGGGCTTTAGAA
CTAAAACTTACTTATATTGTTTTTCCTTAACAGAGGGAGAAAAATAGTGGATTATTATTTCTAAAATAAAAGGATGTTCTGCTTTCTAAA
TATCCCATCAAAATCTTCAGTTTTGCACTTTTTTGATGGAAAATTCATCTTATCTTCCTATGACTTTGGTTTTAGCCTTTCTGAATTTGT
TACCCCTTCTGGATGGCTTATTTGATATACTGGAATAGTTAACAAGCTATACTTCAGCATATGCACTATATTCTAACAAATTTTTTTTAA
TAAAATCAAGACATCAGCAAGAATGACATTTACGTGACCTCATAATGTGGGATTATGGCCTTCTGTTGCTATTCCAGTTTGATATGGAAG
CATCTATATCCTCTATTGCCGTTAGATGTTGTTGCTTTTCAGAAAAGTAACGAAAAGGCTCATTTTAAAGAATCCAAGAAACGATGTCAT
CCAAATATTGACAGTTTCTACATTTCATGCCATCTTTATAACTCAATTGAAAGTTGCCGTCATTCTTGTGAAGTATTTGACAAGTGCAAT
CTGCTAGAAGCTCGTTTTTCTTGTGACTCCCAAATGTTAGTGCTACTTAGCCTCAGTAATGAGTTACAGTTGAAAAAAACATGAGGGAAA
CAGAGGGACAGAGATTTTCTAATGAACAATGATGGAAGAGACCTAATGTCCTTGCTAGAAACAGCCAGGATGGAAATTATCCAGCCCTGG
CATTCTCCTTATCATCAATGACAGTCATTTTATTCATTTATTTCAAATGTGGGTGGGCTAGAAGTGGAAGGAGGGAATTCTCTCTGCCTA
AAAATTCTAGAAGAATGAAAGTAATCTTTGTATCCAGGAAACTAAGAGAATGAGGAATAAATATCTTCAGCCCGACTCCTGAATTTGTTT
ATTCTTCCATCTATAATTAGATTGTGTTTTCATTTTTGCTTTGTCATGCTTTTTGGTTGTTATTTGGCTATACAGTTTTATGCTTTAAAA
CAAATGATAAAGTTAATTTCCAATTCAATAGTGAAATATTAACAATCTAACTATAGCCAGATCAAAGACACCTGAACACAGAAAACCTTT
ATTTGCTGGTGCTGCCATTGCACAGGCTGTACAATGAAATAGATTTGAAAAGCTGATTGATTTTCCCGCACATAAATTCTGGATGTCAAT
TTCCAACCAAACTCCAATACAGCTATGTGGCATGAAGAGTTACAGGAGGGAGGGAGGAAAATAGCCCTATGTTAGTCATGTTTGCATACA
GAGGATCAAAGTAGGCCTTCACCATAATAGTTCTAATTAAAATGGTCCTCGCTGTAGGAGAGACAAAGGGGCTTTTCCTCTAGCTGGTAA
CTATTCAGATGATGGACAAGTCTTCTTTCATAAAAGATTACAAAGAAGGCATCCGAATCACTGTCTGTGATACTGGGTCACATATTAATC
ACTGCAGCTAATTGTAAATCTTTCTATGAAACACTGAAAAGCCTCTTTGTGAATTAATACAGTTCTGCTTGATGCACTTGATTTGAAAAG
ACATTTCTCTGTATGTGGCGCATGTCGGCTTTGCTTTGAAAAATAACAAAGTTAGCAGAATATGTTCAATATATTTTCTTGGGGAATAGG
GTTTTTATTACATGATTCATTAAGGATTTGCCTTACCCTGACATTTGTGATATAAAGGAAAATCAGAAAAAAAGTAATTTTCTTGATCAA
GATATGTTTTTACTTAATGCAAATAAATGTAGTCTGTTGCTTGCAAGGAAAAAAAAATGGCTTCTGATATCTGGTATAAACTGCTAAATA
GGATAATACGTGCCTCTTTTGTTAAACCGGCATTTAAATGCTGGACTGCTTCTAAATCTGTTTGTTTCTTTTCATCTGTGCCATACACTA

>66474_66474_1_PLSCR1-MACROD2_PLSCR1_chr3_146234793_ENST00000342435_MACROD2_chr20_16021846_ENST00000217246_length(amino acids)=337AA_BP=319
MDLVSLGSGNSGSQRTVLIMDKQNSQMNASHPETNLPVGYPPQYPPTAFQGPPGYSGYPGPQVSYPPPPAGHSGPGPAGFPVPNQPVYNQ
PVYNQPVGAAGVPWMPAPQPPLNCPPGLEYLSQIDQILIHQQIELLEVLTGFETNNKYEIKNSFGQRVYFAAEDTDCCTRNCCGPSRPFT
LRIIDNMGQEVITLERPLRCSSCCCPCCLQEIEIQAPPGVPIGYVIQTWHPCLPKFTIQNEKREDVLKISGPCVVCSCCGDVDFEIKSLD

--------------------------------------------------------------
>66474_66474_2_PLSCR1-MACROD2_PLSCR1_chr3_146234793_ENST00000342435_MACROD2_chr20_16021846_ENST00000310348_length(transcript)=1505nt_BP=1311nt
GAGTCCCAGTTCCTCTCCTTAACCACCGGACAAACGTCTCTGGAGTCTCTCCAATGAGCAAGAAAGCAAGTCGGGGGTAGGGGAGGGGCC
TCACACCAGGGGGTGGGCGCAGTCCCTCCTCCAGCTCCTTCACCCTCCAGTAGTCTCGTGGGTCCCCGAGCGCCAGCGCGGGAACCGGGA
AAAGGAAACCGTGTTGTGTACGTAAGATTCAGGAAACGAAACCAGGAGCCGCGGGTGTTGGCGCAAAGGTTACTCCCAGACCCTTTTCCG
GCTGACTTCTGAGAAGGTTGCGCAGCAGCTGTGCCCGGCAGTCTAGAGGCGCAGAAGAGGAAGCCATCGCCTGGCCCCGGCTCTCTGGAC
CTTGTCTCGCTCGGGAGCGGAAACAGCGGCAGCCAGAGAACTGTTTTAATCATGGACAAACAAAACTCACAGATGAATGCTTCTCACCCG
GAAACAAACTTGCCAGTTGGGTATCCTCCTCAGTATCCACCGACAGCATTCCAAGGACCTCCAGGATATAGTGGCTACCCTGGGCCCCAG
GTCAGCTACCCACCCCCACCAGCCGGCCATTCAGGTCCTGGCCCAGCTGGCTTTCCTGTCCCAAATCAGCCAGTGTATAATCAGCCAGTA
TATAATCAGCCAGTTGGAGCTGCAGGGGTACCATGGATGCCAGCGCCACAGCCTCCATTAAACTGTCCACCTGGATTAGAATATTTAAGT
CAGATAGATCAGATACTGATTCATCAGCAAATTGAACTTCTGGAAGTTTTAACAGGTTTTGAAACTAATAACAAATATGAAATTAAGAAC
AGCTTTGGACAGAGGGTTTACTTTGCAGCGGAAGATACTGATTGCTGTACCCGAAATTGCTGTGGGCCATCTAGACCTTTTACCTTGAGG
ATTATTGATAATATGGGTCAAGAAGTCATAACTCTGGAGAGACCACTAAGATGTAGCAGCTGTTGTTGTCCCTGCTGCCTTCAGGAGATA
GAAATCCAAGCTCCTCCTGGTGTACCAATAGGTTATGTTATTCAGACTTGGCACCCATGTCTACCAAAGTTTACAATTCAAAATGAGAAA
AGAGAGGATGTACTAAAAATAAGTGGTCCATGTGTTGTGTGCAGCTGTTGTGGAGATGTTGATTTTGAGATTAAATCTCTTGATGAACAG
TGTGTGGTTGGCAAAATTTCCAAGCACTGGACTGGAATTTTGAGAGAGGCATTTACAGACGCTGATAACTTTGGAATCCAGTTCCCTTTA
GACCTTGATGTTAAAATGAAAGCTGTAATGATTGGTGCCTGTTTCCTCATTCTCCAGGCGAGGACACACCTAGGATGCCTGGGAAAAGTG
AAGGCTCCAGTGACCTAGAAAATACTCCAGGTCCTGATGTTGAAATGAATAGTCAGGTTGACAAGGTAAATGACCCAACAGAGAGTCAAC

>66474_66474_2_PLSCR1-MACROD2_PLSCR1_chr3_146234793_ENST00000342435_MACROD2_chr20_16021846_ENST00000310348_length(amino acids)=337AA_BP=319
MDLVSLGSGNSGSQRTVLIMDKQNSQMNASHPETNLPVGYPPQYPPTAFQGPPGYSGYPGPQVSYPPPPAGHSGPGPAGFPVPNQPVYNQ
PVYNQPVGAAGVPWMPAPQPPLNCPPGLEYLSQIDQILIHQQIELLEVLTGFETNNKYEIKNSFGQRVYFAAEDTDCCTRNCCGPSRPFT
LRIIDNMGQEVITLERPLRCSSCCCPCCLQEIEIQAPPGVPIGYVIQTWHPCLPKFTIQNEKREDVLKISGPCVVCSCCGDVDFEIKSLD

--------------------------------------------------------------
>66474_66474_3_PLSCR1-MACROD2_PLSCR1_chr3_146234793_ENST00000448205_MACROD2_chr20_16021846_ENST00000217246_length(transcript)=3909nt_BP=463nt
GCCCCGGCTCTCTGGACCTTGTCTCGCTCGGGAGCGGAAACAGCGGCAGCCAGAGCATAAAATACACAAGAGGATTTTTATGGAATGGCT
CCTTGTTACAAGGACCACATAAACCCATTTTGAATTATTCAACCATTGCTGAACTTCTTGAAACTGTTTTAATCATGGACAAACAAAACT
CACAGATGAATGCTTCTCACCCGGAAACAAACTTGCCAGTTGGGTATCCTCCTCAGTATCCACCGACAGCATTCCAAGATAGATCAGATA
CTGATTCATCAGCAAATTGAACTTCTGGAAGATTAAATCTCTTGATGAACAGTGTGTGGTTGGCAAAATTTCCAAGCACTGGACTGGAAT
TTTGAGAGAGGCATTTACAGACGCTGATAACTTTGGAATCCAGTTCCCTTTAGACCTTGATGTTAAAATGAAAGCTGTAATGATTGGTGC
CTGTTTCCTCATTCTCCAGGCGAGGACACACCTAGGATGCCTGGGAAAAGTGAAGGCTCCAGTGACCTAGAAAATACTCCAGGTCCTGAT
GCAGGGGCACAAGATGAAGCGAAGGAACAAAGAAATGGAACTAAATGACAATCCTCAGCATCGCAAGGCCTCTCCTGGCTCTGGGGGAGC
TCGGGAAGATAGCAGCACACGCTGTGGAGGAGGGTGGGGGTGGGGGGAAGGCAAGTCCCATGGAAGGACGGGGAATCCTTTACTCTAATT
TCTCCAGCTGCATTTTGTTCCGTTTATCTGCAGAAAAAGAAAGAAAAAAAAGAAAAAAAAAGTTTCCTTTAATTTGGTGGAGGGACCCAT
GTTGACGCATCTTTCAGGCATTATCCTTGTAATTTCTGTCTTTTCTCTTACAACTTTGCCCCAGGGTCACAGTGGCTTGATTGAACACTC
ACATGTGTATCCTGGCCCCTGTCTGCTTTCTTGGTTATTTCACAAAGCTGGTCACACAGTGGTTTATTCAAAGGAAGGGGAGGAAGACAG
TGGTTTGATAAGCTGCAGGATAAATTTTAGGAATCAATGAGCCCAGCAGCAGTATAATCCCCAGACAGAGGAGGCAGGATAGAAAATGGG
CAAAAGCCTCGGAAACCACTTGGAAAAGGTCTGGACAATGAGGTGAAAATATTTTCTTCAGGGTTCCCAAGGCACAATTTGTTCCAAGTG
GCTAATGAGAAATATGGAAGCTGAATTTTTTCCAGAGCAGAGTGCAGAGGCATAACAGAAGGGTGGGCCCTGGCAGCCATCTGGGTCTCT
TCCTTCCTAACCATGGTGGCAGGTGCATCCTTCTTTGACACTGACTTTCAGCAGAGCTTACTTGGTTCATGAGGTCTTCACATGGAGACT
ACCAGCAAGAGGTGACTCTCTGCTGCATAACTGTAAAGGATGGCCCTTTGCTAGGTGTTACAGTTAAAAGCTAAGAAAAGGGGCAGTGCA
TTTAGGACCCAAACATATGCCTATGAATATCAAAAGCTCCTCCTGAAATTGCTGTGAGTTTTCCATAAAAGAATATCCTGTCTTCACCCA
AGGCTTGACAGCCCACAGAGTGGTCTCATTTGAAATTACAGGAAATTAGAGCTTTTGCTTGCAGTTCTGCCTTCCTGGCCTGTGTTTAAA
TGCTGTCACTTGTTTATGCCAAGTTCAAGGCTGATTCAATGGTTGGTCCCCTCACCCAGAAAACCCTGAAGGGGAGGATACAGCTCTGAA
GGGGGGCAGCAGTACTAAAAACCCAAGATGCCAGTGGTATAGTGGGCACAAGGGATGGCGACCATGAGGATGCCAGGCATCATCACCAAT
ATCTATCCTAGAGCCAGTATAAGGCCAGATGCCTACTTCCCACAGCCTCCCCGGGTTCCAAAGTCATGTCATTGTTTTCAGTGGAAACAT
ATCGTTTGTTGCATATCTTCTTAAATCCATCTTCCTTGTAAGGGCTTTAGAACTAAAACTTACTTATATTGTTTTTCCTTAACAGAGGGA
GAAAAATAGTGGATTATTATTTCTAAAATAAAAGGATGTTCTGCTTTCTAAATATCCCATCAAAATCTTCAGTTTTGCACTTTTTTGATG
GAAAATTCATCTTATCTTCCTATGACTTTGGTTTTAGCCTTTCTGAATTTGTTACCCCTTCTGGATGGCTTATTTGATATACTGGAATAG
TTAACAAGCTATACTTCAGCATATGCACTATATTCTAACAAATTTTTTTTAATAAAATCAAGACATCAGCAAGAATGACATTTACGTGAC
CTCATAATGTGGGATTATGGCCTTCTGTTGCTATTCCAGTTTGATATGGAAGCATCTATATCCTCTATTGCCGTTAGATGTTGTTGCTTT
TCAGAAAAGTAACGAAAAGGCTCATTTTAAAGAATCCAAGAAACGATGTCATCCAAATATTGACAGTTTCTACATTTCATGCCATCTTTA
TAACTCAATTGAAAGTTGCCGTCATTCTTGTGAAGTATTTGACAAGTGCAATCTGCTAGAAGCTCGTTTTTCTTGTGACTCCCAAATGTT
AGTGCTACTTAGCCTCAGTAATGAGTTACAGTTGAAAAAAACATGAGGGAAACAGAGGGACAGAGATTTTCTAATGAACAATGATGGAAG
AGACCTAATGTCCTTGCTAGAAACAGCCAGGATGGAAATTATCCAGCCCTGGCATTCTCCTTATCATCAATGACAGTCATTTTATTCATT
TATTTCAAATGTGGGTGGGCTAGAAGTGGAAGGAGGGAATTCTCTCTGCCTAAAAATTCTAGAAGAATGAAAGTAATCTTTGTATCCAGG
AAACTAAGAGAATGAGGAATAAATATCTTCAGCCCGACTCCTGAATTTGTTTATTCTTCCATCTATAATTAGATTGTGTTTTCATTTTTG
CTTTGTCATGCTTTTTGGTTGTTATTTGGCTATACAGTTTTATGCTTTAAAACAAATGATAAAGTTAATTTCCAATTCAATAGTGAAATA
TTAACAATCTAACTATAGCCAGATCAAAGACACCTGAACACAGAAAACCTTTATTTGCTGGTGCTGCCATTGCACAGGCTGTACAATGAA
ATAGATTTGAAAAGCTGATTGATTTTCCCGCACATAAATTCTGGATGTCAATTTCCAACCAAACTCCAATACAGCTATGTGGCATGAAGA
GTTACAGGAGGGAGGGAGGAAAATAGCCCTATGTTAGTCATGTTTGCATACAGAGGATCAAAGTAGGCCTTCACCATAATAGTTCTAATT
AAAATGGTCCTCGCTGTAGGAGAGACAAAGGGGCTTTTCCTCTAGCTGGTAACTATTCAGATGATGGACAAGTCTTCTTTCATAAAAGAT
TACAAAGAAGGCATCCGAATCACTGTCTGTGATACTGGGTCACATATTAATCACTGCAGCTAATTGTAAATCTTTCTATGAAACACTGAA
AAGCCTCTTTGTGAATTAATACAGTTCTGCTTGATGCACTTGATTTGAAAAGACATTTCTCTGTATGTGGCGCATGTCGGCTTTGCTTTG
AAAAATAACAAAGTTAGCAGAATATGTTCAATATATTTTCTTGGGGAATAGGGTTTTTATTACATGATTCATTAAGGATTTGCCTTACCC
TGACATTTGTGATATAAAGGAAAATCAGAAAAAAAGTAATTTTCTTGATCAAGATATGTTTTTACTTAATGCAAATAAATGTAGTCTGTT
GCTTGCAAGGAAAAAAAAATGGCTTCTGATATCTGGTATAAACTGCTAAATAGGATAATACGTGCCTCTTTTGTTAAACCGGCATTTAAA
TGCTGGACTGCTTCTAAATCTGTTTGTTTCTTTTCATCTGTGCCATACACTAAAAAACAACTGTTGCCTTCATACTATATTTGTTAGAGC

>66474_66474_3_PLSCR1-MACROD2_PLSCR1_chr3_146234793_ENST00000448205_MACROD2_chr20_16021846_ENST00000217246_length(amino acids)=100AA_BP=
MHFVPFICRKRKKKKKKKVSFNLVEGPMLTHLSGIILVISVFSLTTLPQGHSGLIEHSHVYPGPCLLSWLFHKAGHTVVYSKEGEEDSGL

--------------------------------------------------------------
>66474_66474_4_PLSCR1-MACROD2_PLSCR1_chr3_146234793_ENST00000448205_MACROD2_chr20_16021846_ENST00000310348_length(transcript)=657nt_BP=463nt
GCCCCGGCTCTCTGGACCTTGTCTCGCTCGGGAGCGGAAACAGCGGCAGCCAGAGCATAAAATACACAAGAGGATTTTTATGGAATGGCT
CCTTGTTACAAGGACCACATAAACCCATTTTGAATTATTCAACCATTGCTGAACTTCTTGAAACTGTTTTAATCATGGACAAACAAAACT
CACAGATGAATGCTTCTCACCCGGAAACAAACTTGCCAGTTGGGTATCCTCCTCAGTATCCACCGACAGCATTCCAAGATAGATCAGATA
CTGATTCATCAGCAAATTGAACTTCTGGAAGATTAAATCTCTTGATGAACAGTGTGTGGTTGGCAAAATTTCCAAGCACTGGACTGGAAT
TTTGAGAGAGGCATTTACAGACGCTGATAACTTTGGAATCCAGTTCCCTTTAGACCTTGATGTTAAAATGAAAGCTGTAATGATTGGTGC
CTGTTTCCTCATTCTCCAGGCGAGGACACACCTAGGATGCCTGGGAAAAGTGAAGGCTCCAGTGACCTAGAAAATACTCCAGGTCCTGAT
GTTGAAATGAATAGTCAGGTTGACAAGGTAAATGACCCAACAGAGAGTCAACAAGAAGATCAACTAATAGCAGGGGCACAAGATGAAGCG

>66474_66474_4_PLSCR1-MACROD2_PLSCR1_chr3_146234793_ENST00000448205_MACROD2_chr20_16021846_ENST00000310348_length(amino acids)=99AA_BP=
MRKQAPIITAFILTSRSKGNWIPKLSASVNASLKIPVQCLEILPTTHCSSRDLIFQKFNLLMNQYLIYLGMLSVDTEEDTQLASLFPGEK

--------------------------------------------------------------
>66474_66474_5_PLSCR1-MACROD2_PLSCR1_chr3_146234793_ENST00000487389_MACROD2_chr20_16021846_ENST00000217246_length(transcript)=4604nt_BP=1158nt
CTTCACCCTCCAGTAGTCTCGTGGGTCCCCGAGCGCCAGCGCGGGAACCGGGAAAAGGAAACCGTGTTGTGTACGTAAGATTCAGGAAAC
GAAACCAGGAGCCGCGGGTGTTGGCGCAAAGGTTACTCCCAGACCCTTTTCCGGCTGACTTCTGAGAAGGTTGCGCAGCAGCTGTGCCCG
GCAGTCTAGAGGCGCAGAAGAGGAAGCCATCGCCTGGCCCCGGCTCTCTGGACCTTGTCTCGCTCGGGAGCGGAAACAGCGGCAGCCAGA
GACTCACAGATGAATGCTTCTCACCCGGAAACAAACTTGCCAGTTGGGTATCCTCCTCAGTATCCACCGACAGCATTCCAAGGACCTCCA
GGATATAGTGGCTACCCTGGGCCCCAGGTCAGCTACCCACCCCCACCAGCCGGCCATTCAGGTCCTGGCCCAGCTGGCTTTCCTGTCCCA
AATCAGCCAGTGTATAATCAGCCAGTATATAATCAGCCAGTTGGAGCTGCAGGGGTACCATGGATGCCAGCGCCACAGCCTCCATTAAAC
TGTCCACCTGGATTAGAATATTTAAGTCAGATAGATCAGATACTGATTCATCAGCAAATTGAACTTCTGGAAGTTTTAACAGGTTTTGAA
ACTAATAACAAATATGAAATTAAGAACAGCTTTGGACAGAGGGTTTACTTTGCAGCGGAAGATACTGATTGCTGTACCCGAAATTGCTGT
GGGCCATCTAGACCTTTTACCTTGAGGATTATTGATAATATGGGTCAAGAAGTCATAACTCTGGAGAGACCACTAAGATGTAGCAGCTGT
TGTTGTCCCTGCTGCCTTCAGGAGATAGAAATCCAAGCTCCTCCTGGTGTACCAATAGGTTATGTTATTCAGACTTGGCACCCATGTCTA
CCAAAGTTTACAATTCAAAATGAGAAAAGAGAGGATGTACTAAAAATAAGTGGTCCATGTGTTGTGTGCAGCTGTTGTGGAGATGTTGAT
TTTGAGATTAAATCTCTTGATGAACAGTGTGTGGTTGGCAAAATTTCCAAGCACTGGACTGGAATTTTGAGAGAGGCATTTACAGACGCT
GATAACTTTGGAATCCAGTTCCCTTTAGACCTTGATGTTAAAATGAAAGCTGTAATGATTGGTGCCTGTTTCCTCATTCTCCAGGCGAGG
ACACACCTAGGATGCCTGGGAAAAGTGAAGGCTCCAGTGACCTAGAAAATACTCCAGGTCCTGATGCAGGGGCACAAGATGAAGCGAAGG
AACAAAGAAATGGAACTAAATGACAATCCTCAGCATCGCAAGGCCTCTCCTGGCTCTGGGGGAGCTCGGGAAGATAGCAGCACACGCTGT
GGAGGAGGGTGGGGGTGGGGGGAAGGCAAGTCCCATGGAAGGACGGGGAATCCTTTACTCTAATTTCTCCAGCTGCATTTTGTTCCGTTT
ATCTGCAGAAAAAGAAAGAAAAAAAAGAAAAAAAAAGTTTCCTTTAATTTGGTGGAGGGACCCATGTTGACGCATCTTTCAGGCATTATC
CTTGTAATTTCTGTCTTTTCTCTTACAACTTTGCCCCAGGGTCACAGTGGCTTGATTGAACACTCACATGTGTATCCTGGCCCCTGTCTG
CTTTCTTGGTTATTTCACAAAGCTGGTCACACAGTGGTTTATTCAAAGGAAGGGGAGGAAGACAGTGGTTTGATAAGCTGCAGGATAAAT
TTTAGGAATCAATGAGCCCAGCAGCAGTATAATCCCCAGACAGAGGAGGCAGGATAGAAAATGGGCAAAAGCCTCGGAAACCACTTGGAA
AAGGTCTGGACAATGAGGTGAAAATATTTTCTTCAGGGTTCCCAAGGCACAATTTGTTCCAAGTGGCTAATGAGAAATATGGAAGCTGAA
TTTTTTCCAGAGCAGAGTGCAGAGGCATAACAGAAGGGTGGGCCCTGGCAGCCATCTGGGTCTCTTCCTTCCTAACCATGGTGGCAGGTG
CATCCTTCTTTGACACTGACTTTCAGCAGAGCTTACTTGGTTCATGAGGTCTTCACATGGAGACTACCAGCAAGAGGTGACTCTCTGCTG
CATAACTGTAAAGGATGGCCCTTTGCTAGGTGTTACAGTTAAAAGCTAAGAAAAGGGGCAGTGCATTTAGGACCCAAACATATGCCTATG
AATATCAAAAGCTCCTCCTGAAATTGCTGTGAGTTTTCCATAAAAGAATATCCTGTCTTCACCCAAGGCTTGACAGCCCACAGAGTGGTC
TCATTTGAAATTACAGGAAATTAGAGCTTTTGCTTGCAGTTCTGCCTTCCTGGCCTGTGTTTAAATGCTGTCACTTGTTTATGCCAAGTT
CAAGGCTGATTCAATGGTTGGTCCCCTCACCCAGAAAACCCTGAAGGGGAGGATACAGCTCTGAAGGGGGGCAGCAGTACTAAAAACCCA
AGATGCCAGTGGTATAGTGGGCACAAGGGATGGCGACCATGAGGATGCCAGGCATCATCACCAATATCTATCCTAGAGCCAGTATAAGGC
CAGATGCCTACTTCCCACAGCCTCCCCGGGTTCCAAAGTCATGTCATTGTTTTCAGTGGAAACATATCGTTTGTTGCATATCTTCTTAAA
TCCATCTTCCTTGTAAGGGCTTTAGAACTAAAACTTACTTATATTGTTTTTCCTTAACAGAGGGAGAAAAATAGTGGATTATTATTTCTA
AAATAAAAGGATGTTCTGCTTTCTAAATATCCCATCAAAATCTTCAGTTTTGCACTTTTTTGATGGAAAATTCATCTTATCTTCCTATGA
CTTTGGTTTTAGCCTTTCTGAATTTGTTACCCCTTCTGGATGGCTTATTTGATATACTGGAATAGTTAACAAGCTATACTTCAGCATATG
CACTATATTCTAACAAATTTTTTTTAATAAAATCAAGACATCAGCAAGAATGACATTTACGTGACCTCATAATGTGGGATTATGGCCTTC
TGTTGCTATTCCAGTTTGATATGGAAGCATCTATATCCTCTATTGCCGTTAGATGTTGTTGCTTTTCAGAAAAGTAACGAAAAGGCTCAT
TTTAAAGAATCCAAGAAACGATGTCATCCAAATATTGACAGTTTCTACATTTCATGCCATCTTTATAACTCAATTGAAAGTTGCCGTCAT
TCTTGTGAAGTATTTGACAAGTGCAATCTGCTAGAAGCTCGTTTTTCTTGTGACTCCCAAATGTTAGTGCTACTTAGCCTCAGTAATGAG
TTACAGTTGAAAAAAACATGAGGGAAACAGAGGGACAGAGATTTTCTAATGAACAATGATGGAAGAGACCTAATGTCCTTGCTAGAAACA
GCCAGGATGGAAATTATCCAGCCCTGGCATTCTCCTTATCATCAATGACAGTCATTTTATTCATTTATTTCAAATGTGGGTGGGCTAGAA
GTGGAAGGAGGGAATTCTCTCTGCCTAAAAATTCTAGAAGAATGAAAGTAATCTTTGTATCCAGGAAACTAAGAGAATGAGGAATAAATA
TCTTCAGCCCGACTCCTGAATTTGTTTATTCTTCCATCTATAATTAGATTGTGTTTTCATTTTTGCTTTGTCATGCTTTTTGGTTGTTAT
TTGGCTATACAGTTTTATGCTTTAAAACAAATGATAAAGTTAATTTCCAATTCAATAGTGAAATATTAACAATCTAACTATAGCCAGATC
AAAGACACCTGAACACAGAAAACCTTTATTTGCTGGTGCTGCCATTGCACAGGCTGTACAATGAAATAGATTTGAAAAGCTGATTGATTT
TCCCGCACATAAATTCTGGATGTCAATTTCCAACCAAACTCCAATACAGCTATGTGGCATGAAGAGTTACAGGAGGGAGGGAGGAAAATA
GCCCTATGTTAGTCATGTTTGCATACAGAGGATCAAAGTAGGCCTTCACCATAATAGTTCTAATTAAAATGGTCCTCGCTGTAGGAGAGA
CAAAGGGGCTTTTCCTCTAGCTGGTAACTATTCAGATGATGGACAAGTCTTCTTTCATAAAAGATTACAAAGAAGGCATCCGAATCACTG
TCTGTGATACTGGGTCACATATTAATCACTGCAGCTAATTGTAAATCTTTCTATGAAACACTGAAAAGCCTCTTTGTGAATTAATACAGT
TCTGCTTGATGCACTTGATTTGAAAAGACATTTCTCTGTATGTGGCGCATGTCGGCTTTGCTTTGAAAAATAACAAAGTTAGCAGAATAT
GTTCAATATATTTTCTTGGGGAATAGGGTTTTTATTACATGATTCATTAAGGATTTGCCTTACCCTGACATTTGTGATATAAAGGAAAAT
CAGAAAAAAAGTAATTTTCTTGATCAAGATATGTTTTTACTTAATGCAAATAAATGTAGTCTGTTGCTTGCAAGGAAAAAAAAATGGCTT
CTGATATCTGGTATAAACTGCTAAATAGGATAATACGTGCCTCTTTTGTTAAACCGGCATTTAAATGCTGGACTGCTTCTAAATCTGTTT
GTTTCTTTTCATCTGTGCCATACACTAAAAAACAACTGTTGCCTTCATACTATATTTGTTAGAGCAGAATACAAATAAAATTTGTTTGAG

>66474_66474_5_PLSCR1-MACROD2_PLSCR1_chr3_146234793_ENST00000487389_MACROD2_chr20_16021846_ENST00000217246_length(amino acids)=333AA_BP=315
MAPALWTLSRSGAETAAARDSQMNASHPETNLPVGYPPQYPPTAFQGPPGYSGYPGPQVSYPPPPAGHSGPGPAGFPVPNQPVYNQPVYN
QPVGAAGVPWMPAPQPPLNCPPGLEYLSQIDQILIHQQIELLEVLTGFETNNKYEIKNSFGQRVYFAAEDTDCCTRNCCGPSRPFTLRII
DNMGQEVITLERPLRCSSCCCPCCLQEIEIQAPPGVPIGYVIQTWHPCLPKFTIQNEKREDVLKISGPCVVCSCCGDVDFEIKSLDEQCV

--------------------------------------------------------------
>66474_66474_6_PLSCR1-MACROD2_PLSCR1_chr3_146234793_ENST00000487389_MACROD2_chr20_16021846_ENST00000310348_length(transcript)=1352nt_BP=1158nt
CTTCACCCTCCAGTAGTCTCGTGGGTCCCCGAGCGCCAGCGCGGGAACCGGGAAAAGGAAACCGTGTTGTGTACGTAAGATTCAGGAAAC
GAAACCAGGAGCCGCGGGTGTTGGCGCAAAGGTTACTCCCAGACCCTTTTCCGGCTGACTTCTGAGAAGGTTGCGCAGCAGCTGTGCCCG
GCAGTCTAGAGGCGCAGAAGAGGAAGCCATCGCCTGGCCCCGGCTCTCTGGACCTTGTCTCGCTCGGGAGCGGAAACAGCGGCAGCCAGA
GACTCACAGATGAATGCTTCTCACCCGGAAACAAACTTGCCAGTTGGGTATCCTCCTCAGTATCCACCGACAGCATTCCAAGGACCTCCA
GGATATAGTGGCTACCCTGGGCCCCAGGTCAGCTACCCACCCCCACCAGCCGGCCATTCAGGTCCTGGCCCAGCTGGCTTTCCTGTCCCA
AATCAGCCAGTGTATAATCAGCCAGTATATAATCAGCCAGTTGGAGCTGCAGGGGTACCATGGATGCCAGCGCCACAGCCTCCATTAAAC
TGTCCACCTGGATTAGAATATTTAAGTCAGATAGATCAGATACTGATTCATCAGCAAATTGAACTTCTGGAAGTTTTAACAGGTTTTGAA
ACTAATAACAAATATGAAATTAAGAACAGCTTTGGACAGAGGGTTTACTTTGCAGCGGAAGATACTGATTGCTGTACCCGAAATTGCTGT
GGGCCATCTAGACCTTTTACCTTGAGGATTATTGATAATATGGGTCAAGAAGTCATAACTCTGGAGAGACCACTAAGATGTAGCAGCTGT
TGTTGTCCCTGCTGCCTTCAGGAGATAGAAATCCAAGCTCCTCCTGGTGTACCAATAGGTTATGTTATTCAGACTTGGCACCCATGTCTA
CCAAAGTTTACAATTCAAAATGAGAAAAGAGAGGATGTACTAAAAATAAGTGGTCCATGTGTTGTGTGCAGCTGTTGTGGAGATGTTGAT
TTTGAGATTAAATCTCTTGATGAACAGTGTGTGGTTGGCAAAATTTCCAAGCACTGGACTGGAATTTTGAGAGAGGCATTTACAGACGCT
GATAACTTTGGAATCCAGTTCCCTTTAGACCTTGATGTTAAAATGAAAGCTGTAATGATTGGTGCCTGTTTCCTCATTCTCCAGGCGAGG
ACACACCTAGGATGCCTGGGAAAAGTGAAGGCTCCAGTGACCTAGAAAATACTCCAGGTCCTGATGTTGAAATGAATAGTCAGGTTGACA
AGGTAAATGACCCAACAGAGAGTCAACAAGAAGATCAACTAATAGCAGGGGCACAAGATGAAGCGAAGGAACAAAGAAATGGAACTAAAT

>66474_66474_6_PLSCR1-MACROD2_PLSCR1_chr3_146234793_ENST00000487389_MACROD2_chr20_16021846_ENST00000310348_length(amino acids)=333AA_BP=315
MAPALWTLSRSGAETAAARDSQMNASHPETNLPVGYPPQYPPTAFQGPPGYSGYPGPQVSYPPPPAGHSGPGPAGFPVPNQPVYNQPVYN
QPVGAAGVPWMPAPQPPLNCPPGLEYLSQIDQILIHQQIELLEVLTGFETNNKYEIKNSFGQRVYFAAEDTDCCTRNCCGPSRPFTLRII
DNMGQEVITLERPLRCSSCCCPCCLQEIEIQAPPGVPIGYVIQTWHPCLPKFTIQNEKREDVLKISGPCVVCSCCGDVDFEIKSLDEQCV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PLSCR1-MACROD2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgenePLSCR1chr3:146234793chr20:16021846ENST00000342435-8999_290300.0319.0hepatitis C virus E2 glycoprotein


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PLSCR1-MACROD2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PLSCR1-MACROD2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource