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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PLXNA1-CHCHD6 (FusionGDB2 ID:66519)

Fusion Gene Summary for PLXNA1-CHCHD6

check button Fusion gene summary
Fusion gene informationFusion gene name: PLXNA1-CHCHD6
Fusion gene ID: 66519
HgeneTgene
Gene symbol

PLXNA1

CHCHD6

Gene ID

5361

84303

Gene nameplexin A1coiled-coil-helix-coiled-coil-helix domain containing 6
SynonymsNOV|NOVP|PLEXIN-A1|PLXN1CHCM1|MICOS25|Mic25|PPP1R23
Cytomap

3q21.3

3q21.3

Type of geneprotein-codingprotein-coding
Descriptionplexin-A1plexin 1semaphorin receptor NOVMICOS complex subunit MIC25coiled coil helix cristae morphology 1coiled-coil-helix cristae morphology protein 1coiled-coil-helix-coiled-coil-helix domain-containing protein 6, mitochondrialmitochondrial contact site and cristae organizing system subun
Modification date2020031320200327
UniProtAcc

Q9UIW2

Q9BRQ6

Ensembl transtripts involved in fusion geneENST00000251772, ENST00000393409, 
ENST00000505278, 		ENST00000515867, 
ENST00000290913, ENST00000508789, 
Fusion gene scores* DoF score8 X 6 X 7=3368 X 8 X 7=448
# samples 911
** MAII scorelog2(9/336*10)=-1.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/448*10)=-2.02599520853294
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PLXNA1 [Title/Abstract] AND CHCHD6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCHCHD6(126423242)-PLXNA1(126748717), # samples:1
PLXNA1(126708630)-CHCHD6(126633523), # samples:2
Anticipated loss of major functional domain due to fusion event.CHCHD6-PLXNA1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCHCHD6

GO:0006974

cellular response to DNA damage stimulus

22228767


check buttonFusion gene breakpoints across PLXNA1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CHCHD6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-CF-A1HS-01APLXNA1chr3

126708630

-CHCHD6chr3

126633523

+
ChimerDB4BLCATCGA-CF-A1HS-01APLXNA1chr3

126708630

+CHCHD6chr3

126633523

+
ChimerDB4PRADTCGA-HC-8265-01APLXNA1chr3

126710409

-CHCHD6chr3

126445921

+


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Fusion Gene ORF analysis for PLXNA1-CHCHD6

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000251772ENST00000515867PLXNA1chr3

126708630

+CHCHD6chr3

126633523

+
5CDS-3UTRENST00000393409ENST00000515867PLXNA1chr3

126708630

+CHCHD6chr3

126633523

+
5CDS-intronENST00000251772ENST00000515867PLXNA1chr3

126710409

-CHCHD6chr3

126445921

+
5CDS-intronENST00000393409ENST00000515867PLXNA1chr3

126710409

-CHCHD6chr3

126445921

+
In-frameENST00000251772ENST00000290913PLXNA1chr3

126708630

+CHCHD6chr3

126633523

+
In-frameENST00000251772ENST00000290913PLXNA1chr3

126710409

-CHCHD6chr3

126445921

+
In-frameENST00000251772ENST00000508789PLXNA1chr3

126708630

+CHCHD6chr3

126633523

+
In-frameENST00000251772ENST00000508789PLXNA1chr3

126710409

-CHCHD6chr3

126445921

+
In-frameENST00000393409ENST00000290913PLXNA1chr3

126708630

+CHCHD6chr3

126633523

+
In-frameENST00000393409ENST00000290913PLXNA1chr3

126710409

-CHCHD6chr3

126445921

+
In-frameENST00000393409ENST00000508789PLXNA1chr3

126708630

+CHCHD6chr3

126633523

+
In-frameENST00000393409ENST00000508789PLXNA1chr3

126710409

-CHCHD6chr3

126445921

+
intron-3CDSENST00000505278ENST00000290913PLXNA1chr3

126708630

+CHCHD6chr3

126633523

+
intron-3CDSENST00000505278ENST00000290913PLXNA1chr3

126710409

-CHCHD6chr3

126445921

+
intron-3CDSENST00000505278ENST00000508789PLXNA1chr3

126708630

+CHCHD6chr3

126633523

+
intron-3CDSENST00000505278ENST00000508789PLXNA1chr3

126710409

-CHCHD6chr3

126445921

+
intron-3UTRENST00000505278ENST00000515867PLXNA1chr3

126708630

+CHCHD6chr3

126633523

+
intron-intronENST00000505278ENST00000515867PLXNA1chr3

126710409

-CHCHD6chr3

126445921

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000393409PLXNA1chr3126710409-ENST00000290913CHCHD6chr3126445921+2203137701997665
ENST00000393409PLXNA1chr3126710409-ENST00000508789CHCHD6chr3126445921+2377137702060686
ENST00000251772PLXNA1chr3126710409-ENST00000290913CHCHD6chr3126445921+2203137701997665
ENST00000251772PLXNA1chr3126710409-ENST00000508789CHCHD6chr3126445921+2377137702060686

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000393409ENST00000290913PLXNA1chr3126710409-CHCHD6chr3126445921+0.0147942530.9852057
ENST00000393409ENST00000508789PLXNA1chr3126710409-CHCHD6chr3126445921+0.0128620640.9871379
ENST00000251772ENST00000290913PLXNA1chr3126710409-CHCHD6chr3126445921+0.0147942530.9852057
ENST00000251772ENST00000508789PLXNA1chr3126710409-CHCHD6chr3126445921+0.0128620640.9871379

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Fusion Genomic Features for PLXNA1-CHCHD6


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PLXNA1chr3126708630+CHCHD6chr3126633522+0.465823050.53417695
PLXNA1chr3126708630+CHCHD6chr3126633522+0.465823050.53417695

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PLXNA1-CHCHD6


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:126423242/chr3:126748717)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PLXNA1

Q9UIW2

CHCHD6

Q9BRQ6

FUNCTION: Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity). {ECO:0000250}.FUNCTION: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. {ECO:0000269|PubMed:22228767}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCHCHD6chr3:126710409chr3:126445921ENST0000029091308129_17629236.0Coiled coilOntology_term=ECO:0000255
TgeneCHCHD6chr3:126708630chr3:126633523ENST0000029091348194_235165236.0DomainCHCH
TgeneCHCHD6chr3:126710409chr3:126445921ENST0000029091308194_23529236.0DomainCHCH
TgeneCHCHD6chr3:126708630chr3:126633523ENST0000029091348197_207165236.0MotifCx9C motif 1
TgeneCHCHD6chr3:126708630chr3:126633523ENST0000029091348218_228165236.0MotifCx9C motif 2
TgeneCHCHD6chr3:126710409chr3:126445921ENST0000029091308197_20729236.0MotifCx9C motif 1
TgeneCHCHD6chr3:126710409chr3:126445921ENST0000029091308218_22829236.0MotifCx9C motif 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePLXNA1chr3:126708630chr3:126633523ENST00000393409+1311264_13173981897.0Coiled coilOntology_term=ECO:0000255
HgenePLXNA1chr3:126710409chr3:126445921ENST00000393409-2311264_13174591897.0Coiled coilOntology_term=ECO:0000255
HgenePLXNA1chr3:126708630chr3:126633523ENST00000393409+1311048_11473981897.0DomainNote=IPT/TIG 3
HgenePLXNA1chr3:126708630chr3:126633523ENST00000393409+1311150_12363981897.0DomainNote=IPT/TIG 4
HgenePLXNA1chr3:126708630chr3:126633523ENST00000393409+13127_5123981897.0DomainSema
HgenePLXNA1chr3:126708630chr3:126633523ENST00000393409+131864_9593981897.0DomainNote=IPT/TIG 1
HgenePLXNA1chr3:126708630chr3:126633523ENST00000393409+131961_10453981897.0DomainNote=IPT/TIG 2
HgenePLXNA1chr3:126710409chr3:126445921ENST00000393409-2311048_11474591897.0DomainNote=IPT/TIG 3
HgenePLXNA1chr3:126710409chr3:126445921ENST00000393409-2311150_12364591897.0DomainNote=IPT/TIG 4
HgenePLXNA1chr3:126710409chr3:126445921ENST00000393409-23127_5124591897.0DomainSema
HgenePLXNA1chr3:126710409chr3:126445921ENST00000393409-231864_9594591897.0DomainNote=IPT/TIG 1
HgenePLXNA1chr3:126710409chr3:126445921ENST00000393409-231961_10454591897.0DomainNote=IPT/TIG 2
HgenePLXNA1chr3:126708630chr3:126633523ENST00000393409+1311266_18963981897.0Topological domainCytoplasmic
HgenePLXNA1chr3:126708630chr3:126633523ENST00000393409+13127_12443981897.0Topological domainExtracellular
HgenePLXNA1chr3:126710409chr3:126445921ENST00000393409-2311266_18964591897.0Topological domainCytoplasmic
HgenePLXNA1chr3:126710409chr3:126445921ENST00000393409-23127_12444591897.0Topological domainExtracellular
HgenePLXNA1chr3:126708630chr3:126633523ENST00000393409+1311245_12653981897.0TransmembraneHelical
HgenePLXNA1chr3:126710409chr3:126445921ENST00000393409-2311245_12654591897.0TransmembraneHelical
TgeneCHCHD6chr3:126708630chr3:126633523ENST0000029091348129_176165236.0Coiled coilOntology_term=ECO:0000255


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Fusion Gene Sequence for PLXNA1-CHCHD6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>66519_66519_1_PLXNA1-CHCHD6_PLXNA1_chr3_126710409_ENST00000251772_CHCHD6_chr3_126445921_ENST00000290913_length(transcript)=2203nt_BP=1377nt
ATGCCGCTGCCACCGCGGAGCCTGCAGGTGCTCCTGCTGCTGCTGCTGTTGCTGCTGCTGCTGCCGGGCATGTGGGCTGAGGCAGGCTTG
CCCAGGGCAGGCGGGGGTTCACAGCCCCCCTTCCGCACCTTCTCGGCCAGCGACTGGGGCCTCACCCACCTAGTGGTGCATGAGCAGACA
GGCGAGGTGTATGTGGGCGCAGTGAACCGCATCTATAAGCTGTCGGGGAACCTGACACTGCTGCGGGCCCACGTCACGGGCCCTGTGGAG
GACAACGAGAAGTGCTACCCGCCGCCCAGCGTGCAGTCCTGCCCCCACGGCCTGGGCAGTACTGACAACGTCAACAAGCTGCTGCTGCTG
GACTATGCCGCTAACCGCCTGCTGGCCTGTGGCAGCGCCTCCCAGGGCATCTGCCAGTTCCTGCGTCTGGACGATCTCTTCAAACTGGGT
GAGCCACACCACCGTAAGGAGCACTACCTGTCCAGCGTGCAGGAGGCAGGCAGCATGGCGGGCGTGCTCATTGCCGGGCCACCGGGCCAG
GGCCAGGCCAAGCTCTTCGTGGGCACACCCATCGATGGCAAGTCCGAGTACTTCCCCACACTGTCCAGCCGTCGGCTCATGGCCAACGAG
GAGGATGCCGACATGTTCGGCTTCGTGTACCAGGATGAGTTTGTGTCATCACAGCTCAAGATCCCTTCGGACACGCTGTCCAAGTTCCCG
GCCTTTGACATCTACTATGTGTACAGCTTCCGCAGCGAGCAGTTTGTCTACTACCTCACGCTGCAGCTAGACACACAGCTGACCTCGCCT
GATGCCGCCGGCGAGCACTTCTTCACGTCCAAGATCGTGCGGCTCTGTGTGGACGACCCCAAATTCTACTCGTACGTTGAGTTCCCCATT
GGCTGCGAGCAGGCGGGTGTGGAGTACCGCCTGGTGCAGGATGCCTACCTGAGCCGGCCCGGCCGTGCCCTGGCCCACCAGCTGGGCCTG
GCTGAGGACGAGGACGTGCTGTTCACTGTGTTCGCCCAGGGCCAGAAGAACCGCGTGAAGCCACCAAAGGAGTCAGCACTGTGCCTGTTC
ACGCTCAGGGCCATCAAGGAGAAGATTAAGGAGCGCATCCAGTCCTGCTACCGTGGTGAGGGCAAGCTCTCCCTGCCGTGGCTGCTCAAC
AAGGAGCTGGGCTGCATCAACTCGCCCCTGCAGATCGATGACGACTTCTGCGGGCAGGACTTCAACCAGCCCCTGGGGGGCACAGTCACC
ATTGAGGGGACGCCCCTGTTCGTGGACAAGGATGATGGCCTGACCGCCGTGGCTGCCTATGACTATCGGGGCCGCACTGTGGTATTCGCC
GGCACGCGAAGTGGCCGCATCCGCAAGCTGTCTGAAAACGTGGTGAACCGCATGAAGGAGCCCAGCTCTCCACCCCCTGCTCCCACATCT
TCTACCTTTGGCCTTCAAGATGGCAACTTGAGAGCCCCTCACAAAGAATCCACACTGCCCAGGTCGGGGAGCAGTGGTGGCCAGCAGCCC
TCAGGGATGAAGGAGGGTGTCAAGAGGTATGAACAGGAGCATGCTGCTATCCAGGATAAGCTCTTCCAGGTGGCAAAGAGGGAAAGAGAG
GCTGCCACCAAGCACTCCAAGGCATCCCTGCCCACGGGCGAAGGCAGCATCAGCCATGAGGAGCAGAAGTCAGTCCGGCTGGCCAGGGAG
CTGGAGAGCAGAGAGGCAGAGCTAAGACGCCGTGACACCTTCTACAAGGAGCAGCTGGAGCGTATTGAGAGGAAGAATGCTGAGATGTAT
AAACTGTCTTCAGAGCAATTCCATGAGGCAGCCTCAAAGATGGAGAGCACAATAAAGCCCCGCAGGGTGGAGCCCGTCTGCTCAGGGTTG
CAGGCCCAGATTCTCCACTGCTACCGAGATCGCCCGCATGAGGTGCTGCTGTGCTCGGACCTGGTCAAGGCATACCAGCGCTGCGTGAGC
GCCGCCCACAAGGGCTGAGGAGCAGACATCATTCCCTGCCCTGGCAGTGACTTGGAGCCCTGAAGAAGGGACCAATCATGGGACCACAGC
CACTGTGCCCTGCCGTTTCCTGCTGGGCCCCTGCATATGCCCCTGAGCCTGGGGCTGCCACGTGTTTAGGAAACAAAGTATGCGCTACTG

>66519_66519_1_PLXNA1-CHCHD6_PLXNA1_chr3_126710409_ENST00000251772_CHCHD6_chr3_126445921_ENST00000290913_length(amino acids)=665AA_BP=459
MPLPPRSLQVLLLLLLLLLLLPGMWAEAGLPRAGGGSQPPFRTFSASDWGLTHLVVHEQTGEVYVGAVNRIYKLSGNLTLLRAHVTGPVE
DNEKCYPPPSVQSCPHGLGSTDNVNKLLLLDYAANRLLACGSASQGICQFLRLDDLFKLGEPHHRKEHYLSSVQEAGSMAGVLIAGPPGQ
GQAKLFVGTPIDGKSEYFPTLSSRRLMANEEDADMFGFVYQDEFVSSQLKIPSDTLSKFPAFDIYYVYSFRSEQFVYYLTLQLDTQLTSP
DAAGEHFFTSKIVRLCVDDPKFYSYVEFPIGCEQAGVEYRLVQDAYLSRPGRALAHQLGLAEDEDVLFTVFAQGQKNRVKPPKESALCLF
TLRAIKEKIKERIQSCYRGEGKLSLPWLLNKELGCINSPLQIDDDFCGQDFNQPLGGTVTIEGTPLFVDKDDGLTAVAAYDYRGRTVVFA
GTRSGRIRKLSENVVNRMKEPSSPPPAPTSSTFGLQDGNLRAPHKESTLPRSGSSGGQQPSGMKEGVKRYEQEHAAIQDKLFQVAKRERE
AATKHSKASLPTGEGSISHEEQKSVRLARELESREAELRRRDTFYKEQLERIERKNAEMYKLSSEQFHEAASKMESTIKPRRVEPVCSGL

--------------------------------------------------------------
>66519_66519_2_PLXNA1-CHCHD6_PLXNA1_chr3_126710409_ENST00000251772_CHCHD6_chr3_126445921_ENST00000508789_length(transcript)=2377nt_BP=1377nt
ATGCCGCTGCCACCGCGGAGCCTGCAGGTGCTCCTGCTGCTGCTGCTGTTGCTGCTGCTGCTGCCGGGCATGTGGGCTGAGGCAGGCTTG
CCCAGGGCAGGCGGGGGTTCACAGCCCCCCTTCCGCACCTTCTCGGCCAGCGACTGGGGCCTCACCCACCTAGTGGTGCATGAGCAGACA
GGCGAGGTGTATGTGGGCGCAGTGAACCGCATCTATAAGCTGTCGGGGAACCTGACACTGCTGCGGGCCCACGTCACGGGCCCTGTGGAG
GACAACGAGAAGTGCTACCCGCCGCCCAGCGTGCAGTCCTGCCCCCACGGCCTGGGCAGTACTGACAACGTCAACAAGCTGCTGCTGCTG
GACTATGCCGCTAACCGCCTGCTGGCCTGTGGCAGCGCCTCCCAGGGCATCTGCCAGTTCCTGCGTCTGGACGATCTCTTCAAACTGGGT
GAGCCACACCACCGTAAGGAGCACTACCTGTCCAGCGTGCAGGAGGCAGGCAGCATGGCGGGCGTGCTCATTGCCGGGCCACCGGGCCAG
GGCCAGGCCAAGCTCTTCGTGGGCACACCCATCGATGGCAAGTCCGAGTACTTCCCCACACTGTCCAGCCGTCGGCTCATGGCCAACGAG
GAGGATGCCGACATGTTCGGCTTCGTGTACCAGGATGAGTTTGTGTCATCACAGCTCAAGATCCCTTCGGACACGCTGTCCAAGTTCCCG
GCCTTTGACATCTACTATGTGTACAGCTTCCGCAGCGAGCAGTTTGTCTACTACCTCACGCTGCAGCTAGACACACAGCTGACCTCGCCT
GATGCCGCCGGCGAGCACTTCTTCACGTCCAAGATCGTGCGGCTCTGTGTGGACGACCCCAAATTCTACTCGTACGTTGAGTTCCCCATT
GGCTGCGAGCAGGCGGGTGTGGAGTACCGCCTGGTGCAGGATGCCTACCTGAGCCGGCCCGGCCGTGCCCTGGCCCACCAGCTGGGCCTG
GCTGAGGACGAGGACGTGCTGTTCACTGTGTTCGCCCAGGGCCAGAAGAACCGCGTGAAGCCACCAAAGGAGTCAGCACTGTGCCTGTTC
ACGCTCAGGGCCATCAAGGAGAAGATTAAGGAGCGCATCCAGTCCTGCTACCGTGGTGAGGGCAAGCTCTCCCTGCCGTGGCTGCTCAAC
AAGGAGCTGGGCTGCATCAACTCGCCCCTGCAGATCGATGACGACTTCTGCGGGCAGGACTTCAACCAGCCCCTGGGGGGCACAGTCACC
ATTGAGGGGACGCCCCTGTTCGTGGACAAGGATGATGGCCTGACCGCCGTGGCTGCCTATGACTATCGGGGCCGCACTGTGGTATTCGCC
GGCACGCGAAGTGGCCGCATCCGCAAGCTGTCTGAAAACGTGGTGAACCGCATGAAGGAGCCCAGCTCTCCACCCCCTGCTCCCACATCT
TCTACCTTTGGCCTTCAAGATGGCAACTTGAGAGCCCCTCACAAAGAATCCACACTGCCCAGGTCGGGGAGCAGTGGTGGCCAGCAGCCC
TCAGGGATGAAGGAGGGTGTCAAGAGGTATGAACAGGAGCATGCTGCTATCCAGGATAAGCTCTTCCAGGTGGCAAAGAGGGAAAGAGAG
GCTGCCACCAAGCACTCCAAGGCATCCCTGCCCACGGGCGAAGGCAGCATCAGCCATGAGGAGCAGAAGTCAGTCCGGCTGCAGGCCAGG
GAGCTGGAGAGCAGAGAGGCAGAGCTAAGACGCCGTGACACCTTCTACAAGGAGCAGCTGGAGCGTATTGAGAGGAAGAATGCTGAGATG
TATAAACTGTCTTCAGAGCAATTCCATGAGGCAGCCTCAAAGATGGAGAGCACAATAAAGCCCCGCAGGGTGGAGCCCGTCTGCTCAGGG
TTGCAGGCCCAGATTCTCCACTGCTACCGAGATCGCCCGCATGAGGTGCTGCTGTGCTCGGACCTGGTCAAGGCATACCAGCGCTGCGTG
AGCGCCGCCCACAAGGTAAGGCCTTGCCTGCCTCCCAGGTTTCCAAGGGCCTTGGGAGGTAGGCGAGGTACCTCTATCTAGCATTGGAGA
TCTCTGCCTGCCTTTTCCTGTTAGAATCAGATGCTCCACTTGGAGGTCTCTGCATTTGCCAAGGGAGGGATTCTTCGCTTTCCTCAGTCA
CCTGCACACTCTCCTGGCTGCTTCCAGGAGCGCCTTGGACATCTGGCCCCAGGGAGATGATCCCTGTTGCGTTTGCCCTATTAGGCTGGG
TGGGAGCAGGCTGGGTAAAGTCAGGCCCCACCTTCAAGGGCCGGGCCCCTTGTGGGTGCCGGGGACTTCTTAGCCCTCGGCACTTAGGGG

>66519_66519_2_PLXNA1-CHCHD6_PLXNA1_chr3_126710409_ENST00000251772_CHCHD6_chr3_126445921_ENST00000508789_length(amino acids)=686AA_BP=459
MPLPPRSLQVLLLLLLLLLLLPGMWAEAGLPRAGGGSQPPFRTFSASDWGLTHLVVHEQTGEVYVGAVNRIYKLSGNLTLLRAHVTGPVE
DNEKCYPPPSVQSCPHGLGSTDNVNKLLLLDYAANRLLACGSASQGICQFLRLDDLFKLGEPHHRKEHYLSSVQEAGSMAGVLIAGPPGQ
GQAKLFVGTPIDGKSEYFPTLSSRRLMANEEDADMFGFVYQDEFVSSQLKIPSDTLSKFPAFDIYYVYSFRSEQFVYYLTLQLDTQLTSP
DAAGEHFFTSKIVRLCVDDPKFYSYVEFPIGCEQAGVEYRLVQDAYLSRPGRALAHQLGLAEDEDVLFTVFAQGQKNRVKPPKESALCLF
TLRAIKEKIKERIQSCYRGEGKLSLPWLLNKELGCINSPLQIDDDFCGQDFNQPLGGTVTIEGTPLFVDKDDGLTAVAAYDYRGRTVVFA
GTRSGRIRKLSENVVNRMKEPSSPPPAPTSSTFGLQDGNLRAPHKESTLPRSGSSGGQQPSGMKEGVKRYEQEHAAIQDKLFQVAKRERE
AATKHSKASLPTGEGSISHEEQKSVRLQARELESREAELRRRDTFYKEQLERIERKNAEMYKLSSEQFHEAASKMESTIKPRRVEPVCSG

--------------------------------------------------------------
>66519_66519_3_PLXNA1-CHCHD6_PLXNA1_chr3_126710409_ENST00000393409_CHCHD6_chr3_126445921_ENST00000290913_length(transcript)=2203nt_BP=1377nt
ATGCCGCTGCCACCGCGGAGCCTGCAGGTGCTCCTGCTGCTGCTGCTGTTGCTGCTGCTGCTGCCGGGCATGTGGGCTGAGGCAGGCTTG
CCCAGGGCAGGCGGGGGTTCACAGCCCCCCTTCCGCACCTTCTCGGCCAGCGACTGGGGCCTCACCCACCTAGTGGTGCATGAGCAGACA
GGCGAGGTGTATGTGGGCGCAGTGAACCGCATCTATAAGCTGTCGGGGAACCTGACACTGCTGCGGGCCCACGTCACGGGCCCTGTGGAG
GACAACGAGAAGTGCTACCCGCCGCCCAGCGTGCAGTCCTGCCCCCACGGCCTGGGCAGTACTGACAACGTCAACAAGCTGCTGCTGCTG
GACTATGCCGCTAACCGCCTGCTGGCCTGTGGCAGCGCCTCCCAGGGCATCTGCCAGTTCCTGCGTCTGGACGATCTCTTCAAACTGGGT
GAGCCACACCACCGTAAGGAGCACTACCTGTCCAGCGTGCAGGAGGCAGGCAGCATGGCGGGCGTGCTCATTGCCGGGCCACCGGGCCAG
GGCCAGGCCAAGCTCTTCGTGGGCACACCCATCGATGGCAAGTCCGAGTACTTCCCCACACTGTCCAGCCGTCGGCTCATGGCCAACGAG
GAGGATGCCGACATGTTCGGCTTCGTGTACCAGGATGAGTTTGTGTCATCACAGCTCAAGATCCCTTCGGACACGCTGTCCAAGTTCCCG
GCCTTTGACATCTACTATGTGTACAGCTTCCGCAGCGAGCAGTTTGTCTACTACCTCACGCTGCAGCTAGACACACAGCTGACCTCGCCT
GATGCCGCCGGCGAGCACTTCTTCACGTCCAAGATCGTGCGGCTCTGTGTGGACGACCCCAAATTCTACTCGTACGTTGAGTTCCCCATT
GGCTGCGAGCAGGCGGGTGTGGAGTACCGCCTGGTGCAGGATGCCTACCTGAGCCGGCCCGGCCGTGCCCTGGCCCACCAGCTGGGCCTG
GCTGAGGACGAGGACGTGCTGTTCACTGTGTTCGCCCAGGGCCAGAAGAACCGCGTGAAGCCACCAAAGGAGTCAGCACTGTGCCTGTTC
ACGCTCAGGGCCATCAAGGAGAAGATTAAGGAGCGCATCCAGTCCTGCTACCGTGGTGAGGGCAAGCTCTCCCTGCCGTGGCTGCTCAAC
AAGGAGCTGGGCTGCATCAACTCGCCCCTGCAGATCGATGACGACTTCTGCGGGCAGGACTTCAACCAGCCCCTGGGGGGCACAGTCACC
ATTGAGGGGACGCCCCTGTTCGTGGACAAGGATGATGGCCTGACCGCCGTGGCTGCCTATGACTATCGGGGCCGCACTGTGGTATTCGCC
GGCACGCGAAGTGGCCGCATCCGCAAGCTGTCTGAAAACGTGGTGAACCGCATGAAGGAGCCCAGCTCTCCACCCCCTGCTCCCACATCT
TCTACCTTTGGCCTTCAAGATGGCAACTTGAGAGCCCCTCACAAAGAATCCACACTGCCCAGGTCGGGGAGCAGTGGTGGCCAGCAGCCC
TCAGGGATGAAGGAGGGTGTCAAGAGGTATGAACAGGAGCATGCTGCTATCCAGGATAAGCTCTTCCAGGTGGCAAAGAGGGAAAGAGAG
GCTGCCACCAAGCACTCCAAGGCATCCCTGCCCACGGGCGAAGGCAGCATCAGCCATGAGGAGCAGAAGTCAGTCCGGCTGGCCAGGGAG
CTGGAGAGCAGAGAGGCAGAGCTAAGACGCCGTGACACCTTCTACAAGGAGCAGCTGGAGCGTATTGAGAGGAAGAATGCTGAGATGTAT
AAACTGTCTTCAGAGCAATTCCATGAGGCAGCCTCAAAGATGGAGAGCACAATAAAGCCCCGCAGGGTGGAGCCCGTCTGCTCAGGGTTG
CAGGCCCAGATTCTCCACTGCTACCGAGATCGCCCGCATGAGGTGCTGCTGTGCTCGGACCTGGTCAAGGCATACCAGCGCTGCGTGAGC
GCCGCCCACAAGGGCTGAGGAGCAGACATCATTCCCTGCCCTGGCAGTGACTTGGAGCCCTGAAGAAGGGACCAATCATGGGACCACAGC
CACTGTGCCCTGCCGTTTCCTGCTGGGCCCCTGCATATGCCCCTGAGCCTGGGGCTGCCACGTGTTTAGGAAACAAAGTATGCGCTACTG

>66519_66519_3_PLXNA1-CHCHD6_PLXNA1_chr3_126710409_ENST00000393409_CHCHD6_chr3_126445921_ENST00000290913_length(amino acids)=665AA_BP=459
MPLPPRSLQVLLLLLLLLLLLPGMWAEAGLPRAGGGSQPPFRTFSASDWGLTHLVVHEQTGEVYVGAVNRIYKLSGNLTLLRAHVTGPVE
DNEKCYPPPSVQSCPHGLGSTDNVNKLLLLDYAANRLLACGSASQGICQFLRLDDLFKLGEPHHRKEHYLSSVQEAGSMAGVLIAGPPGQ
GQAKLFVGTPIDGKSEYFPTLSSRRLMANEEDADMFGFVYQDEFVSSQLKIPSDTLSKFPAFDIYYVYSFRSEQFVYYLTLQLDTQLTSP
DAAGEHFFTSKIVRLCVDDPKFYSYVEFPIGCEQAGVEYRLVQDAYLSRPGRALAHQLGLAEDEDVLFTVFAQGQKNRVKPPKESALCLF
TLRAIKEKIKERIQSCYRGEGKLSLPWLLNKELGCINSPLQIDDDFCGQDFNQPLGGTVTIEGTPLFVDKDDGLTAVAAYDYRGRTVVFA
GTRSGRIRKLSENVVNRMKEPSSPPPAPTSSTFGLQDGNLRAPHKESTLPRSGSSGGQQPSGMKEGVKRYEQEHAAIQDKLFQVAKRERE
AATKHSKASLPTGEGSISHEEQKSVRLARELESREAELRRRDTFYKEQLERIERKNAEMYKLSSEQFHEAASKMESTIKPRRVEPVCSGL

--------------------------------------------------------------
>66519_66519_4_PLXNA1-CHCHD6_PLXNA1_chr3_126710409_ENST00000393409_CHCHD6_chr3_126445921_ENST00000508789_length(transcript)=2377nt_BP=1377nt
ATGCCGCTGCCACCGCGGAGCCTGCAGGTGCTCCTGCTGCTGCTGCTGTTGCTGCTGCTGCTGCCGGGCATGTGGGCTGAGGCAGGCTTG
CCCAGGGCAGGCGGGGGTTCACAGCCCCCCTTCCGCACCTTCTCGGCCAGCGACTGGGGCCTCACCCACCTAGTGGTGCATGAGCAGACA
GGCGAGGTGTATGTGGGCGCAGTGAACCGCATCTATAAGCTGTCGGGGAACCTGACACTGCTGCGGGCCCACGTCACGGGCCCTGTGGAG
GACAACGAGAAGTGCTACCCGCCGCCCAGCGTGCAGTCCTGCCCCCACGGCCTGGGCAGTACTGACAACGTCAACAAGCTGCTGCTGCTG
GACTATGCCGCTAACCGCCTGCTGGCCTGTGGCAGCGCCTCCCAGGGCATCTGCCAGTTCCTGCGTCTGGACGATCTCTTCAAACTGGGT
GAGCCACACCACCGTAAGGAGCACTACCTGTCCAGCGTGCAGGAGGCAGGCAGCATGGCGGGCGTGCTCATTGCCGGGCCACCGGGCCAG
GGCCAGGCCAAGCTCTTCGTGGGCACACCCATCGATGGCAAGTCCGAGTACTTCCCCACACTGTCCAGCCGTCGGCTCATGGCCAACGAG
GAGGATGCCGACATGTTCGGCTTCGTGTACCAGGATGAGTTTGTGTCATCACAGCTCAAGATCCCTTCGGACACGCTGTCCAAGTTCCCG
GCCTTTGACATCTACTATGTGTACAGCTTCCGCAGCGAGCAGTTTGTCTACTACCTCACGCTGCAGCTAGACACACAGCTGACCTCGCCT
GATGCCGCCGGCGAGCACTTCTTCACGTCCAAGATCGTGCGGCTCTGTGTGGACGACCCCAAATTCTACTCGTACGTTGAGTTCCCCATT
GGCTGCGAGCAGGCGGGTGTGGAGTACCGCCTGGTGCAGGATGCCTACCTGAGCCGGCCCGGCCGTGCCCTGGCCCACCAGCTGGGCCTG
GCTGAGGACGAGGACGTGCTGTTCACTGTGTTCGCCCAGGGCCAGAAGAACCGCGTGAAGCCACCAAAGGAGTCAGCACTGTGCCTGTTC
ACGCTCAGGGCCATCAAGGAGAAGATTAAGGAGCGCATCCAGTCCTGCTACCGTGGTGAGGGCAAGCTCTCCCTGCCGTGGCTGCTCAAC
AAGGAGCTGGGCTGCATCAACTCGCCCCTGCAGATCGATGACGACTTCTGCGGGCAGGACTTCAACCAGCCCCTGGGGGGCACAGTCACC
ATTGAGGGGACGCCCCTGTTCGTGGACAAGGATGATGGCCTGACCGCCGTGGCTGCCTATGACTATCGGGGCCGCACTGTGGTATTCGCC
GGCACGCGAAGTGGCCGCATCCGCAAGCTGTCTGAAAACGTGGTGAACCGCATGAAGGAGCCCAGCTCTCCACCCCCTGCTCCCACATCT
TCTACCTTTGGCCTTCAAGATGGCAACTTGAGAGCCCCTCACAAAGAATCCACACTGCCCAGGTCGGGGAGCAGTGGTGGCCAGCAGCCC
TCAGGGATGAAGGAGGGTGTCAAGAGGTATGAACAGGAGCATGCTGCTATCCAGGATAAGCTCTTCCAGGTGGCAAAGAGGGAAAGAGAG
GCTGCCACCAAGCACTCCAAGGCATCCCTGCCCACGGGCGAAGGCAGCATCAGCCATGAGGAGCAGAAGTCAGTCCGGCTGCAGGCCAGG
GAGCTGGAGAGCAGAGAGGCAGAGCTAAGACGCCGTGACACCTTCTACAAGGAGCAGCTGGAGCGTATTGAGAGGAAGAATGCTGAGATG
TATAAACTGTCTTCAGAGCAATTCCATGAGGCAGCCTCAAAGATGGAGAGCACAATAAAGCCCCGCAGGGTGGAGCCCGTCTGCTCAGGG
TTGCAGGCCCAGATTCTCCACTGCTACCGAGATCGCCCGCATGAGGTGCTGCTGTGCTCGGACCTGGTCAAGGCATACCAGCGCTGCGTG
AGCGCCGCCCACAAGGTAAGGCCTTGCCTGCCTCCCAGGTTTCCAAGGGCCTTGGGAGGTAGGCGAGGTACCTCTATCTAGCATTGGAGA
TCTCTGCCTGCCTTTTCCTGTTAGAATCAGATGCTCCACTTGGAGGTCTCTGCATTTGCCAAGGGAGGGATTCTTCGCTTTCCTCAGTCA
CCTGCACACTCTCCTGGCTGCTTCCAGGAGCGCCTTGGACATCTGGCCCCAGGGAGATGATCCCTGTTGCGTTTGCCCTATTAGGCTGGG
TGGGAGCAGGCTGGGTAAAGTCAGGCCCCACCTTCAAGGGCCGGGCCCCTTGTGGGTGCCGGGGACTTCTTAGCCCTCGGCACTTAGGGG

>66519_66519_4_PLXNA1-CHCHD6_PLXNA1_chr3_126710409_ENST00000393409_CHCHD6_chr3_126445921_ENST00000508789_length(amino acids)=686AA_BP=459
MPLPPRSLQVLLLLLLLLLLLPGMWAEAGLPRAGGGSQPPFRTFSASDWGLTHLVVHEQTGEVYVGAVNRIYKLSGNLTLLRAHVTGPVE
DNEKCYPPPSVQSCPHGLGSTDNVNKLLLLDYAANRLLACGSASQGICQFLRLDDLFKLGEPHHRKEHYLSSVQEAGSMAGVLIAGPPGQ
GQAKLFVGTPIDGKSEYFPTLSSRRLMANEEDADMFGFVYQDEFVSSQLKIPSDTLSKFPAFDIYYVYSFRSEQFVYYLTLQLDTQLTSP
DAAGEHFFTSKIVRLCVDDPKFYSYVEFPIGCEQAGVEYRLVQDAYLSRPGRALAHQLGLAEDEDVLFTVFAQGQKNRVKPPKESALCLF
TLRAIKEKIKERIQSCYRGEGKLSLPWLLNKELGCINSPLQIDDDFCGQDFNQPLGGTVTIEGTPLFVDKDDGLTAVAAYDYRGRTVVFA
GTRSGRIRKLSENVVNRMKEPSSPPPAPTSSTFGLQDGNLRAPHKESTLPRSGSSGGQQPSGMKEGVKRYEQEHAAIQDKLFQVAKRERE
AATKHSKASLPTGEGSISHEEQKSVRLQARELESREAELRRRDTFYKEQLERIERKNAEMYKLSSEQFHEAASKMESTIKPRRVEPVCSG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PLXNA1-CHCHD6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PLXNA1-CHCHD6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PLXNA1-CHCHD6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource