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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PLXNB1-PLXNB3 (FusionGDB2 ID:66555)

Fusion Gene Summary for PLXNB1-PLXNB3

check button Fusion gene summary
Fusion gene informationFusion gene name: PLXNB1-PLXNB3
Fusion gene ID: 66555
HgeneTgene
Gene symbol

PLXNB1

PLXNB3

Gene ID

5364

5365

Gene nameplexin B1plexin B3
SynonymsPLEXIN-B1|PLXN5|SEPPLEXB3|PLEXR|PLXN6
Cytomap

3p21.31

Xq28

Type of geneprotein-codingprotein-coding
Descriptionplexin-B1plexin 5semaphorin receptor SEPplexin-B3plexin 6
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000296440, ENST00000358459, 
ENST00000358536, ENST00000448774, 
ENST00000456774, ENST00000465117, 
ENST00000485980, ENST00000538282, 
ENST00000538543, ENST00000538776, 
ENST00000361971, ENST00000538966, 
Fusion gene scores* DoF score13 X 16 X 8=16642 X 2 X 2=8
# samples 132
** MAII scorelog2(13/1664*10)=-3.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: PLXNB1 [Title/Abstract] AND PLXNB3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPLXNB1(48450978)-PLXNB3(153043402), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePLXNB1

GO:0007162

negative regulation of cell adhesion

15218527

HgenePLXNB1

GO:0008360

regulation of cell shape

19843518

HgenePLXNB1

GO:0051493

regulation of cytoskeleton organization

19843518

HgenePLXNB1

GO:0071526

semaphorin-plexin signaling pathway

15218527|19843518

TgenePLXNB3

GO:0007156

homophilic cell adhesion via plasma membrane adhesion molecules

16122393

TgenePLXNB3

GO:0007162

negative regulation of cell adhesion

15218527

TgenePLXNB3

GO:0010976

positive regulation of neuron projection development

16122393

TgenePLXNB3

GO:0050918

positive chemotaxis

15218527

TgenePLXNB3

GO:0060326

cell chemotaxis

15218527

TgenePLXNB3

GO:0071526

semaphorin-plexin signaling pathway

15218527


check buttonFusion gene breakpoints across PLXNB1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PLXNB3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-Cancer135NPLXNB1chr3

48450978

-PLXNB3chrX

153043402

+


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Fusion Gene ORF analysis for PLXNB1-PLXNB3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000296440ENST00000485980PLXNB1chr3

48450978

-PLXNB3chrX

153043402

+
5CDS-3UTRENST00000358459ENST00000485980PLXNB1chr3

48450978

-PLXNB3chrX

153043402

+
5CDS-3UTRENST00000358536ENST00000485980PLXNB1chr3

48450978

-PLXNB3chrX

153043402

+
5CDS-3UTRENST00000448774ENST00000485980PLXNB1chr3

48450978

-PLXNB3chrX

153043402

+
5CDS-3UTRENST00000456774ENST00000485980PLXNB1chr3

48450978

-PLXNB3chrX

153043402

+
5CDS-intronENST00000296440ENST00000538282PLXNB1chr3

48450978

-PLXNB3chrX

153043402

+
5CDS-intronENST00000296440ENST00000538543PLXNB1chr3

48450978

-PLXNB3chrX

153043402

+
5CDS-intronENST00000296440ENST00000538776PLXNB1chr3

48450978

-PLXNB3chrX

153043402

+
5CDS-intronENST00000358459ENST00000538282PLXNB1chr3

48450978

-PLXNB3chrX

153043402

+
5CDS-intronENST00000358459ENST00000538543PLXNB1chr3

48450978

-PLXNB3chrX

153043402

+
5CDS-intronENST00000358459ENST00000538776PLXNB1chr3

48450978

-PLXNB3chrX

153043402

+
5CDS-intronENST00000358536ENST00000538282PLXNB1chr3

48450978

-PLXNB3chrX

153043402

+
5CDS-intronENST00000358536ENST00000538543PLXNB1chr3

48450978

-PLXNB3chrX

153043402

+
5CDS-intronENST00000358536ENST00000538776PLXNB1chr3

48450978

-PLXNB3chrX

153043402

+
5CDS-intronENST00000448774ENST00000538282PLXNB1chr3

48450978

-PLXNB3chrX

153043402

+
5CDS-intronENST00000448774ENST00000538543PLXNB1chr3

48450978

-PLXNB3chrX

153043402

+
5CDS-intronENST00000448774ENST00000538776PLXNB1chr3

48450978

-PLXNB3chrX

153043402

+
5CDS-intronENST00000456774ENST00000538282PLXNB1chr3

48450978

-PLXNB3chrX

153043402

+
5CDS-intronENST00000456774ENST00000538543PLXNB1chr3

48450978

-PLXNB3chrX

153043402

+
5CDS-intronENST00000456774ENST00000538776PLXNB1chr3

48450978

-PLXNB3chrX

153043402

+
Frame-shiftENST00000358459ENST00000361971PLXNB1chr3

48450978

-PLXNB3chrX

153043402

+
Frame-shiftENST00000358459ENST00000538966PLXNB1chr3

48450978

-PLXNB3chrX

153043402

+
Frame-shiftENST00000358536ENST00000361971PLXNB1chr3

48450978

-PLXNB3chrX

153043402

+
Frame-shiftENST00000358536ENST00000538966PLXNB1chr3

48450978

-PLXNB3chrX

153043402

+
Frame-shiftENST00000448774ENST00000361971PLXNB1chr3

48450978

-PLXNB3chrX

153043402

+
Frame-shiftENST00000448774ENST00000538966PLXNB1chr3

48450978

-PLXNB3chrX

153043402

+
In-frameENST00000296440ENST00000361971PLXNB1chr3

48450978

-PLXNB3chrX

153043402

+
In-frameENST00000296440ENST00000538966PLXNB1chr3

48450978

-PLXNB3chrX

153043402

+
In-frameENST00000456774ENST00000361971PLXNB1chr3

48450978

-PLXNB3chrX

153043402

+
In-frameENST00000456774ENST00000538966PLXNB1chr3

48450978

-PLXNB3chrX

153043402

+
intron-3CDSENST00000465117ENST00000361971PLXNB1chr3

48450978

-PLXNB3chrX

153043402

+
intron-3CDSENST00000465117ENST00000538966PLXNB1chr3

48450978

-PLXNB3chrX

153043402

+
intron-3UTRENST00000465117ENST00000485980PLXNB1chr3

48450978

-PLXNB3chrX

153043402

+
intron-intronENST00000465117ENST00000538282PLXNB1chr3

48450978

-PLXNB3chrX

153043402

+
intron-intronENST00000465117ENST00000538543PLXNB1chr3

48450978

-PLXNB3chrX

153043402

+
intron-intronENST00000465117ENST00000538776PLXNB1chr3

48450978

-PLXNB3chrX

153043402

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000296440PLXNB1chr348450978-ENST00000538966PLXNB3chrX153043402+6818604210365102135
ENST00000296440PLXNB1chr348450978-ENST00000361971PLXNB3chrX153043402+6813604210365102135
ENST00000456774PLXNB1chr348450978-ENST00000538966PLXNB3chrX153043402+61665390058581952
ENST00000456774PLXNB1chr348450978-ENST00000361971PLXNB3chrX153043402+61615390058581952

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000296440ENST00000538966PLXNB1chr348450978-PLXNB3chrX153043402+0.0029115390.9970885
ENST00000296440ENST00000361971PLXNB1chr348450978-PLXNB3chrX153043402+0.0029183050.9970817
ENST00000456774ENST00000538966PLXNB1chr348450978-PLXNB3chrX153043402+0.0023048180.99769515
ENST00000456774ENST00000361971PLXNB1chr348450978-PLXNB3chrX153043402+0.0023100150.99768996

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Fusion Genomic Features for PLXNB1-PLXNB3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PLXNB1chr348450978-PLXNB3chrX153043402+0.0011674770.9988325
PLXNB1chr348450978-PLXNB3chrX153043402+0.0011674770.9988325

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PLXNB1-PLXNB3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:48450978/chrX:153043402)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePLXNB1chr3:48450978chrX:153043402ENST00000296440-33381507_153919792136.0Coiled coilOntology_term=ECO:0000255
HgenePLXNB1chr3:48450978chrX:153043402ENST00000358459-34391507_153917961953.0Coiled coilOntology_term=ECO:0000255
HgenePLXNB1chr3:48450978chrX:153043402ENST00000358536-33381507_153919792136.0Coiled coilOntology_term=ECO:0000255
HgenePLXNB1chr3:48450978chrX:153043402ENST00000456774-32371507_153917961953.0Coiled coilOntology_term=ECO:0000255
HgenePLXNB1chr3:48450978chrX:153043402ENST00000296440-3338678_82919792136.0Compositional biasNote=Pro-rich
HgenePLXNB1chr3:48450978chrX:153043402ENST00000358459-3439678_82917961953.0Compositional biasNote=Pro-rich
HgenePLXNB1chr3:48450978chrX:153043402ENST00000358536-3338678_82919792136.0Compositional biasNote=Pro-rich
HgenePLXNB1chr3:48450978chrX:153043402ENST00000456774-3237678_82917961953.0Compositional biasNote=Pro-rich
HgenePLXNB1chr3:48450978chrX:153043402ENST00000296440-33381070_116019792136.0DomainNote=IPT/TIG 1
HgenePLXNB1chr3:48450978chrX:153043402ENST00000296440-33381162_124919792136.0DomainNote=IPT/TIG 2
HgenePLXNB1chr3:48450978chrX:153043402ENST00000296440-33381252_137519792136.0DomainNote=IPT/TIG 3
HgenePLXNB1chr3:48450978chrX:153043402ENST00000296440-333820_47919792136.0DomainSema
HgenePLXNB1chr3:48450978chrX:153043402ENST00000358459-34391070_116017961953.0DomainNote=IPT/TIG 1
HgenePLXNB1chr3:48450978chrX:153043402ENST00000358459-34391162_124917961953.0DomainNote=IPT/TIG 2
HgenePLXNB1chr3:48450978chrX:153043402ENST00000358459-34391252_137517961953.0DomainNote=IPT/TIG 3
HgenePLXNB1chr3:48450978chrX:153043402ENST00000358459-343920_47917961953.0DomainSema
HgenePLXNB1chr3:48450978chrX:153043402ENST00000358536-33381070_116019792136.0DomainNote=IPT/TIG 1
HgenePLXNB1chr3:48450978chrX:153043402ENST00000358536-33381162_124919792136.0DomainNote=IPT/TIG 2
HgenePLXNB1chr3:48450978chrX:153043402ENST00000358536-33381252_137519792136.0DomainNote=IPT/TIG 3
HgenePLXNB1chr3:48450978chrX:153043402ENST00000358536-333820_47919792136.0DomainSema
HgenePLXNB1chr3:48450978chrX:153043402ENST00000456774-32371070_116017961953.0DomainNote=IPT/TIG 1
HgenePLXNB1chr3:48450978chrX:153043402ENST00000456774-32371162_124917961953.0DomainNote=IPT/TIG 2
HgenePLXNB1chr3:48450978chrX:153043402ENST00000456774-32371252_137517961953.0DomainNote=IPT/TIG 3
HgenePLXNB1chr3:48450978chrX:153043402ENST00000456774-323720_47917961953.0DomainSema
HgenePLXNB1chr3:48450978chrX:153043402ENST00000296440-333820_149019792136.0Topological domainExtracellular
HgenePLXNB1chr3:48450978chrX:153043402ENST00000358459-343920_149017961953.0Topological domainExtracellular
HgenePLXNB1chr3:48450978chrX:153043402ENST00000358536-333820_149019792136.0Topological domainExtracellular
HgenePLXNB1chr3:48450978chrX:153043402ENST00000456774-323720_149017961953.0Topological domainExtracellular
HgenePLXNB1chr3:48450978chrX:153043402ENST00000296440-33381491_151119792136.0TransmembraneHelical
HgenePLXNB1chr3:48450978chrX:153043402ENST00000358459-34391491_151117961953.0TransmembraneHelical
HgenePLXNB1chr3:48450978chrX:153043402ENST00000358536-33381491_151119792136.0TransmembraneHelical
HgenePLXNB1chr3:48450978chrX:153043402ENST00000456774-32371491_151117961953.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePLXNB1chr3:48450978chrX:153043402ENST00000296440-33381512_213519792136.0Topological domainCytoplasmic
HgenePLXNB1chr3:48450978chrX:153043402ENST00000358459-34391512_213517961953.0Topological domainCytoplasmic
HgenePLXNB1chr3:48450978chrX:153043402ENST00000358536-33381512_213519792136.0Topological domainCytoplasmic
HgenePLXNB1chr3:48450978chrX:153043402ENST00000456774-32371512_213517961953.0Topological domainCytoplasmic
TgenePLXNB3chr3:48450978chrX:153043402ENST0000036197130361015_114517531910.0DomainNote=IPT/TIG 3
TgenePLXNB3chr3:48450978chrX:153043402ENST0000036197130361159_124417531910.0DomainNote=IPT/TIG 4
TgenePLXNB3chr3:48450978chrX:153043402ENST00000361971303645_47117531910.0DomainSema
TgenePLXNB3chr3:48450978chrX:153043402ENST000003619713036473_52617531910.0DomainNote=PSI 1
TgenePLXNB3chr3:48450978chrX:153043402ENST000003619713036620_68217531910.0DomainNote=PSI 2
TgenePLXNB3chr3:48450978chrX:153043402ENST000003619713036787_83317531910.0DomainNote=PSI 3
TgenePLXNB3chr3:48450978chrX:153043402ENST000003619713036835_92517531910.0DomainNote=IPT/TIG 1
TgenePLXNB3chr3:48450978chrX:153043402ENST000003619713036927_101217531910.0DomainNote=IPT/TIG 2
TgenePLXNB3chr3:48450978chrX:153043402ENST0000053896631371015_114517761933.0DomainNote=IPT/TIG 3
TgenePLXNB3chr3:48450978chrX:153043402ENST0000053896631371159_124417761933.0DomainNote=IPT/TIG 4
TgenePLXNB3chr3:48450978chrX:153043402ENST00000538966313745_47117761933.0DomainSema
TgenePLXNB3chr3:48450978chrX:153043402ENST000005389663137473_52617761933.0DomainNote=PSI 1
TgenePLXNB3chr3:48450978chrX:153043402ENST000005389663137620_68217761933.0DomainNote=PSI 2
TgenePLXNB3chr3:48450978chrX:153043402ENST000005389663137787_83317761933.0DomainNote=PSI 3
TgenePLXNB3chr3:48450978chrX:153043402ENST000005389663137835_92517761933.0DomainNote=IPT/TIG 1
TgenePLXNB3chr3:48450978chrX:153043402ENST000005389663137927_101217761933.0DomainNote=IPT/TIG 2
TgenePLXNB3chr3:48450978chrX:153043402ENST0000036197130361277_190917531910.0Topological domainCytoplasmic
TgenePLXNB3chr3:48450978chrX:153043402ENST00000361971303645_125517531910.0Topological domainExtracellular
TgenePLXNB3chr3:48450978chrX:153043402ENST0000053896631371277_190917761933.0Topological domainCytoplasmic
TgenePLXNB3chr3:48450978chrX:153043402ENST00000538966313745_125517761933.0Topological domainExtracellular
TgenePLXNB3chr3:48450978chrX:153043402ENST0000036197130361256_127617531910.0TransmembraneHelical
TgenePLXNB3chr3:48450978chrX:153043402ENST0000053896631371256_127617761933.0TransmembraneHelical


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Fusion Gene Sequence for PLXNB1-PLXNB3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>66555_66555_1_PLXNB1-PLXNB3_PLXNB1_chr3_48450978_ENST00000296440_PLXNB3_chrX_153043402_ENST00000361971_length(transcript)=6813nt_BP=6042nt
AGGGCCAGGTGCGCAGGGGAGAAACAAGGCGCCTTGGAGTTCAGGTGACTCCCACACGGGTCATGCTGTTGTCTCCTGATCCAGCCGGCC
CTGCCAGGTGACCATGCCTGCTCTGGGCCCAGCTCTTCTCCAGGCTCTCTGGGCCGGGTGGGTCCTCACCCTCCAGCCCCTTCCACCAAC
TGCATTCACTCCCAATGGCACGTATCTGCAGCACCTGGCAAGGGACCCCACCTCAGGCACCCTCTACCTGGGGGCTACCAACTTCCTGTT
CCAGCTGAGCCCTGGGCTGCAGCTGGAGGCCACAGTGTCCACCGGCCCTGTGCTAGACAGCAGGGACTGCCTGCCACCTGTGATGCCTGA
TGAGTGCCCCCAGGCCCAGCCTACCAACAACCCGAATCAGCTGCTCCTGGTGAGCCCAGGGGCCCTGGTGGTATGCGGGAGCGTGCACCA
GGGGGTCTGTGAACAGCGGCGCCTGGGGCAGCTCGAGCAGCTGCTGCTGCGGCCAGAGCGGCCTGGGGACACACAATATGTGGCTGCCAA
TGATCCTGCGGTCAGCACGGTGGGGCTGGTAGCCCAGGGCTTGGCAGGGGAGCCCCTCCTGTTTGTGGGGCGAGGATACACCAGCAGGGG
TGTGGGGGGTGGCATTCCACCCATCACAACCCGGGCCCTGTGGCCGCCCGACCCCCAAGCTGCCTTCTCCTATGAGGAGACAGCCAAGCT
GGCAGTGGGCCGCCTCTCCGAGTACAGCCACCACTTCGTGAGTGCCTTTGCACGTGGGGCCAGCGCCTACTTCCTGTTCCTGCGGCGGGA
CCTGCAGGCTCAGTCTAGAGCTTTTCGTGCCTATGTATCTCGAGTGTGTCTCCGGGACCAGCACTACTACTCCTATGTGGAGTTGCCTCT
GGCCTGCGAAGGTGGCCGCTACGGGCTGATCCAGGCTGCAGCTGTGGCCACGTCCAGGGAGGTGGCGCATGGGGAGGTGCTCTTTGCAGC
TTTCTCCTCGGCTGCACCCCCCACTGTGGGCCGGCCCCCATCGGCGGCTGCTGGGGCATCTGGAGCCTCTGCCCTCTGTGCCTTCCCCCT
GGATGAGGTGGACCGGCTTGCTAATCGCACGCGAGATGCCTGCTACACCCGGGAGGGTCGTGCTGAGGATGGGACCGAGGTGGCCTACAT
CGAGTATGATGTCAATTCTGACTGTGCACAGCTGCCAGTGGACACCCTGGATGCTTATCCCTGTGGCTCAGACCACACGCCCAGCCCCAT
GGCCAGCCGGGTCCCGCTGGAAGCCACACCAATTCTGGAGTGGCCAGGGATTCAGCTAACAGCTGTGGCAGTCACCATGGAAGATGGACA
CACCATCGCTTTCCTGGGTGATAGTCAAGGGCAGCTGCACAGGGTCTACTTGGGCCCAGGGAGCGATGGCCACCCATACTCCACACAGAG
CATCCAGCAGGGGTCTGCAGTGAGCAGAGACCTCACCTTTGATGGGACCTTTGAGCACCTGTATGTCATGACCCAGAGCACACTTCTGAA
GGTTCCTGTGGCTTCCTGTGCTCAGCACCTGGACTGTGCATCTTGCCTTGCTCACAGGGACCCATACTGTGGGTGGTGCGTGCTCCTTGG
CAGGTGCAGTCGCCGTTCTGAGTGCTCGAGGGGCCAGGGCCCAGAGCAGTGGCTATGGAGCTTCCAGCCTGAGCTGGGCTGTCTGCAAGT
GGCAGCCATGAGTCCTGCCAACATCAGCCGAGAGGAGACGAGGGAGGTTTTCCTATCAGTGCCAGACCTGCCACCCCTGTGGCCAGGGGA
GTCATATTCCTGCCACTTTGGGGAACATCAGAGTCCTGCCCTGCTGACTGGTTCTGGTGTGATGTGCCCCTCCCCAGACCCTAGTGAGGC
CCCAGTGCTGCCGAGAGGAGCCGACTACGTATCCGTGAGCGTGGAGCTCAGATTTGGCGCTGTTGTGATCGCCAAAACTTCCCTCTCTTT
CTATGACTGTGTGGCGGTCACTGAACTCCGCCCATCTGCGCAGTGCCAGGCCTGTGTGAGCAGCCGCTGGGGGTGTAACTGGTGTGTCTG
GCAGCACCTGTGCACCCACAAGGCCTCGTGTGATGCTGGGCCCATGGTTGCAAGCCATCAGAGCCCGCTTGTCTCCCCAGACCCTCCTGC
AAGAGGTGGACCCAGCCCCTCCCCACCCACAGCCCCCAAAGCCCTGGCCACCCCTGCTCCTGACACCCTTCCCGTGGAGCCTGGGGCTCC
CTCCACAGCCACAGCTTCGGACATCTCACCTGGGGCTAGTCCTTCCCTGCTCAGCCCCTGGGGGCCATGGGCAGGTTCTGGCTCCATATC
TTCCCCTGGCTCCACAGGGTCGCCTCTCCATGAGGAGCCCTCCCCTCCCAGCCCCCAAAATGGACCTGGAACCGCTGTCCCTGCCCCCAC
TGACTTCAGACCCTCAGCCACACCTGAGGACCTCTTGGCCTCCCCGCTGTCACCGTCAGAGGTAGCAGCAGTGCCCCCTGCAGACCCTGG
CCCCGAGGCTCTTCATCCCACAGTGCCCCTGGACCTGCCCCCTGCCACTGTTCCTGCCACCACTTTCCCAGGGGCCATGGGCTCCGTGAA
GCCCGCCCTGGACTGGCTCACGAGAGAAGGCGGCGAGCTGCCCGAGGCGGACGAGTGGACGGGGGGTGACGCACCCGCCTTCTCCACTTC
CACCCTCCTCTCAGGTGATGGAGACTCAGCAGAGCTTGAGGGCCCTCCCGCCCCCCTCATCCTCCCGTCCAGCCTCGACTACCAGTATGA
CACCCCCGGGCTCTGGGAGCTGGAAGAGGCGACCTTGGGGGCAAGCTCCTGCCCCTGTGTGGAGAGCGTTCAGGGCTCCACGTTGATGCC
GGTCCATGTGGAGCGGGAAATCCGGCTGCTAGGCAGGAACCTGCACCTTTTCCAGGATGGCCCAGGAGACAATGAGTGTGTGATGGAGCT
GGAGGGCCTCGAGGTGGTGGTTGAGGCCCGGGTCGAGTGTGAGCCACCTCCAGATACCCAGTGCCATGTCACCTGCCAGCAGCACCAGCT
CAGCTATGAGGCTCTGCAGCCGGAGCTCCGTGTGGGGCTGTTTCTGCGTCGGGCCGGCCGTCTGCGTGTGGACAGTGCTGAGGGGCTGCA
TGTGGTACTGTATGACTGTTCCGTGGGACATGGAGACTGCAGCCGCTGCCAAACTGCCATGCCCCAGTATGGCTGTGTGTGGTGTGAGGG
GGAGCGTCCACGTTGTGTGACCCGGGAGGCCTGTGGTGAGGCTGAGGCTGTGGCCACCCAGTGCCCAGCGCCCCTCATCCACTCGGTGGA
GCCACTGACTGGGCCTGTAGACGGAGGCACCCGTGTCACCATCAGGGGCTCCAACCTGGGCCAGCATGTGCAGGATGTGCTGGGCATGGT
CACGGTGGCTGGAGTGCCCTGTGCTGTGGATGCCCAGGAGTACGAGGTCTCCAGCAGCCTCGTGTGCATCACCGGGGCCAGTGGGGAGGA
GGTGGCCGGCGCCACAGCGGTGGAGGTGCCGGGAAGAGGACGTGGTGTCTCAGAACACGACTTTGCCTACCAGGATCCGAAGGTCCATTC
CATCTTCCCGGCCCGCGGCCCCAGAGCTGGGGGCACCCGTCTCACCCTGAATGGCTCCAAGCTCCTGACTGGGCGGCTGGAGGACATCCG
AGTGGTGGTTGGAGACCAGCCTTGTCACTTGCTGCCGGAGCAGCAGTCAGAACAACTGCGGTGTGAGACCAGCCCACGCCCCACGCCTGC
CACGCTCCCTGTGGCTGTGTGGTTTGGGGCCACGGAGCGGAGGCTTCAACGCGGACAGTTCAAGTATACCTTGGACCCCAACATCACCTC
TGCTGGCCCCACCAAGAGCTTCCTCAGTGGAGGACGTGAGATATGCGTCCGTGGCCAGAATCTGGACGTGGTACAGACGCCAAGAATCCG
GGTGACCGTGGTCTCGAGAATGCTGCAGCCCAGCCAGGGGCTTGGACGGAGGCGTCGCGTGGTCCCGGAGACGGCATGTTCCCTTGGACC
CTCCTGCAGTAGCCAGCAATTTGAGGAGCCGTGCCATGTCAACTCCTCCCAGCTCATCACGTGCCGCACACCTGCCCTCCCAGGCCTGCC
TGAGGACCCCTGGGTCCGGGTGGAATTTATCCTTGACAACCTGGTCTTTGACTTTGCAACACTGAACCCCACACCTTTCTCCTATGAGGC
CGACCCCACCCTGCAGCCACTCAACCCTGAGGACCCCACCATGCCATTCCGGCACAAGCCTGGGAGTGTGTTCTCCGTGGAGGGGGAGAA
CCTGGACCTTGCAATGTCCAAGGAGGAGGTGGTGGCTATGATAGGGGATGGCCCCTGTGTGGTGAAGACGCTGACGCGGCACCACCTGTA
CTGCGAGCCCCCCGTGGAGCAGCCCCTGCCACGGCACCATGCCCTCCGAGAGGCACCTGACTCTTTGCCTGAGTTCACGGTGCAGATGGG
GAACTTGCGCTTCTCCCTGGGTCACGTGCAGTATGACGGCGAGAGCCCTGGGGCTTTTCCTGTGGCAGCCCAGGTGGGCTTGGGGGTGGG
CACCTCTCTTCTGGCTCTGGGTGTCATCATCATTGTCCTCATGTACAGGAGGAAGAGCAAGCAGGCCCTGAGGGACTATAAGAAGGTTCA
GATCCAGCTGGAGAATCTGGAGAGCAGTGTGCGGGACCGCTGCAAGAAGGAATTCACAGACCTCATGACTGAGATGACCGATCTCACCAG
TGACCTCCTGGGCAGCGGCATCCCCTTCCTCGACTACAAGGTGTATGCGGAGAGGATCTTCTTCCCTGGGCACCGCGAGTCGCCCTTGCA
CCGGGACCTGGGTGTGCCTGAGAGCAGACGGCCCACTGTGGAGCAAGGGCTGGGGCAGCTCTCTAACCTGCTCAACAGCAAGCTCTTCCT
CACCAAGTTCATCCACACGCTGGAGAGCCAGCGCACCTTTTCAGCTCGGGACCGTGCCTACGTGGCATCTCTGCTCACCGTGGCACTGCA
TGGGAAGCTTGAGTATTTCACTGACATCCTCCGCACTCTGCTCAGTGACCTGGTTGCCCAGTATGTGGCCAAGAACCCCAAGCTGATGCT
GCGCAGGACAGAGACTGTGGTGGAGAAGCTGCTCACCAACTGGATGTCCATCTGTCTGTATACCTTCGTGAGGGACTCCGTAGGGGAGCC
TCTGTACATGCTCTTTCGAGGGATTAAGCACCAAGTGGATAAGGGGCCAGTGGACAGTGTGACAGGCAAGGCCAAATACACCTTGAACGA
CAACCGCCTGCTCAGAGAGGATGTGGAGTACCGTCCCCTGACCTTGAATGCACTATTGGCTGTGGGGCCTGGGGCAGGAGAGGCCCAGGG
CGTGCCCGTGAAGGTCCTAGACTGTGACACCATCTCCCAGGCAAAGGAGAAGATGCTGGACCAGCTTTATAAAGGAGTGCCTCTCACCCA
GCGGCCAGACCCTCGCACCCTTGATGTTGAGTGGCGGTCTGGGGTGGCCGGGCACCTCATTCTTTCTGACGAGGATGTCACTTCTGAGGT
CCAGGGTCTGTGGAGGCGCCTGAACACACTGCAGCATTACAAGGTCCCAGATGGAGCAACTGTGGCCCTCGTCCCCTGCCTCACCAAGCA
TGTGCTCCGGGAAAACCAGGATTATGTCCCTGGAGAGCGGACCCCAATGCTGGAGGATGTAGATGAGGGGGGCATCCGGCCCTGGCACCT
GGTGAAGCCAAGTGATGAGCCGGAGCCGCCCAGGCCTCGGAGGGGCAGCCTTCGGGGCGGGGAGCGTGAGCGCGCCAAGGCCATCCCTGA
GATCTACCTGACCCGCCTGCTGTCCATGAAGGGCACCCTGCAGAAGTTCGTGGATGACCTGTTCCAGGTGATTCTCAGCACCAGCCGCCC
CGTGCCGCTCGCTGTGAAGTACTTCTTTGACCTGCTGGATGAGCAGGCCCAGCAGCATGGCATCTCCGACCAGGACACCATCCACATCTG
GAAGACCAACAGTCTGCTGCTGCGGTTCTGGGTGAATGCCTTGAAGAACCCACAGCTCATCTTTGATGTACGGGTGTCGGACAATGTGGA
CGCCATCCTTGCTGTCATCGCCCAGACCTTCATTGACTCCTGTACCACCTCGGAGCATAAAGTGGGCCGGGATTCCCCAGTGAACAAACT
GCTCTACGCCCGGGAGATCCCACGCTACAAGCAGATGGTGGAGAGGTACTATGCGGACATTCGCCAGAGCTCTCCGGCGAGCTACCAGGA
GATGAACTCTGCTTTGGCTGAGCTCTCCGGGAACTACACTTCTGCTCCCCACTGTCTGGAGGCTCTGCAAGAACTCTACAACCACATCCA
CAGGTACTATGATCAGATTATCAGTGCCCTGGAGGAGGACCCTGTGGGCCAGAAGCTGCAGCTGGCCTGCCGCCTGCAGCAGGTCGCCGC
CCTGGTGGAAAACAAAGTGACTGACCTGTGAGCTCTGGCTCAGACAGCAGCAAGCCGGATCCACCAACACCGCAGCGCCTTATGACCCCG
GAACCGAGCCAGCCACTGAGGGGAGCTGGCAGAGCCTGGGGGCACAGGGTGCAAAGCCAGGCACTGTGCCCAGCAGTGGGCTCCCTGCCT
GCCACCTCCCCTGCCAGCCCACCCACCTTCCCCCCACCTGAGATTGTTTCTAATTTATAAGGATCCCCCTCCTTCCCCCTCTCCCCATTG

>66555_66555_1_PLXNB1-PLXNB3_PLXNB1_chr3_48450978_ENST00000296440_PLXNB3_chrX_153043402_ENST00000361971_length(amino acids)=2135AA_BP=32
MPALGPALLQALWAGWVLTLQPLPPTAFTPNGTYLQHLARDPTSGTLYLGATNFLFQLSPGLQLEATVSTGPVLDSRDCLPPVMPDECPQ
AQPTNNPNQLLLVSPGALVVCGSVHQGVCEQRRLGQLEQLLLRPERPGDTQYVAANDPAVSTVGLVAQGLAGEPLLFVGRGYTSRGVGGG
IPPITTRALWPPDPQAAFSYEETAKLAVGRLSEYSHHFVSAFARGASAYFLFLRRDLQAQSRAFRAYVSRVCLRDQHYYSYVELPLACEG
GRYGLIQAAAVATSREVAHGEVLFAAFSSAAPPTVGRPPSAAAGASGASALCAFPLDEVDRLANRTRDACYTREGRAEDGTEVAYIEYDV
NSDCAQLPVDTLDAYPCGSDHTPSPMASRVPLEATPILEWPGIQLTAVAVTMEDGHTIAFLGDSQGQLHRVYLGPGSDGHPYSTQSIQQG
SAVSRDLTFDGTFEHLYVMTQSTLLKVPVASCAQHLDCASCLAHRDPYCGWCVLLGRCSRRSECSRGQGPEQWLWSFQPELGCLQVAAMS
PANISREETREVFLSVPDLPPLWPGESYSCHFGEHQSPALLTGSGVMCPSPDPSEAPVLPRGADYVSVSVELRFGAVVIAKTSLSFYDCV
AVTELRPSAQCQACVSSRWGCNWCVWQHLCTHKASCDAGPMVASHQSPLVSPDPPARGGPSPSPPTAPKALATPAPDTLPVEPGAPSTAT
ASDISPGASPSLLSPWGPWAGSGSISSPGSTGSPLHEEPSPPSPQNGPGTAVPAPTDFRPSATPEDLLASPLSPSEVAAVPPADPGPEAL
HPTVPLDLPPATVPATTFPGAMGSVKPALDWLTREGGELPEADEWTGGDAPAFSTSTLLSGDGDSAELEGPPAPLILPSSLDYQYDTPGL
WELEEATLGASSCPCVESVQGSTLMPVHVEREIRLLGRNLHLFQDGPGDNECVMELEGLEVVVEARVECEPPPDTQCHVTCQQHQLSYEA
LQPELRVGLFLRRAGRLRVDSAEGLHVVLYDCSVGHGDCSRCQTAMPQYGCVWCEGERPRCVTREACGEAEAVATQCPAPLIHSVEPLTG
PVDGGTRVTIRGSNLGQHVQDVLGMVTVAGVPCAVDAQEYEVSSSLVCITGASGEEVAGATAVEVPGRGRGVSEHDFAYQDPKVHSIFPA
RGPRAGGTRLTLNGSKLLTGRLEDIRVVVGDQPCHLLPEQQSEQLRCETSPRPTPATLPVAVWFGATERRLQRGQFKYTLDPNITSAGPT
KSFLSGGREICVRGQNLDVVQTPRIRVTVVSRMLQPSQGLGRRRRVVPETACSLGPSCSSQQFEEPCHVNSSQLITCRTPALPGLPEDPW
VRVEFILDNLVFDFATLNPTPFSYEADPTLQPLNPEDPTMPFRHKPGSVFSVEGENLDLAMSKEEVVAMIGDGPCVVKTLTRHHLYCEPP
VEQPLPRHHALREAPDSLPEFTVQMGNLRFSLGHVQYDGESPGAFPVAAQVGLGVGTSLLALGVIIIVLMYRRKSKQALRDYKKVQIQLE
NLESSVRDRCKKEFTDLMTEMTDLTSDLLGSGIPFLDYKVYAERIFFPGHRESPLHRDLGVPESRRPTVEQGLGQLSNLLNSKLFLTKFI
HTLESQRTFSARDRAYVASLLTVALHGKLEYFTDILRTLLSDLVAQYVAKNPKLMLRRTETVVEKLLTNWMSICLYTFVRDSVGEPLYML
FRGIKHQVDKGPVDSVTGKAKYTLNDNRLLREDVEYRPLTLNALLAVGPGAGEAQGVPVKVLDCDTISQAKEKMLDQLYKGVPLTQRPDP
RTLDVEWRSGVAGHLILSDEDVTSEVQGLWRRLNTLQHYKVPDGATVALVPCLTKHVLRENQDYVPGERTPMLEDVDEGGIRPWHLVKPS
DEPEPPRPRRGSLRGGERERAKAIPEIYLTRLLSMKGTLQKFVDDLFQVILSTSRPVPLAVKYFFDLLDEQAQQHGISDQDTIHIWKTNS
LLLRFWVNALKNPQLIFDVRVSDNVDAILAVIAQTFIDSCTTSEHKVGRDSPVNKLLYAREIPRYKQMVERYYADIRQSSPASYQEMNSA

--------------------------------------------------------------
>66555_66555_2_PLXNB1-PLXNB3_PLXNB1_chr3_48450978_ENST00000296440_PLXNB3_chrX_153043402_ENST00000538966_length(transcript)=6818nt_BP=6042nt
AGGGCCAGGTGCGCAGGGGAGAAACAAGGCGCCTTGGAGTTCAGGTGACTCCCACACGGGTCATGCTGTTGTCTCCTGATCCAGCCGGCC
CTGCCAGGTGACCATGCCTGCTCTGGGCCCAGCTCTTCTCCAGGCTCTCTGGGCCGGGTGGGTCCTCACCCTCCAGCCCCTTCCACCAAC
TGCATTCACTCCCAATGGCACGTATCTGCAGCACCTGGCAAGGGACCCCACCTCAGGCACCCTCTACCTGGGGGCTACCAACTTCCTGTT
CCAGCTGAGCCCTGGGCTGCAGCTGGAGGCCACAGTGTCCACCGGCCCTGTGCTAGACAGCAGGGACTGCCTGCCACCTGTGATGCCTGA
TGAGTGCCCCCAGGCCCAGCCTACCAACAACCCGAATCAGCTGCTCCTGGTGAGCCCAGGGGCCCTGGTGGTATGCGGGAGCGTGCACCA
GGGGGTCTGTGAACAGCGGCGCCTGGGGCAGCTCGAGCAGCTGCTGCTGCGGCCAGAGCGGCCTGGGGACACACAATATGTGGCTGCCAA
TGATCCTGCGGTCAGCACGGTGGGGCTGGTAGCCCAGGGCTTGGCAGGGGAGCCCCTCCTGTTTGTGGGGCGAGGATACACCAGCAGGGG
TGTGGGGGGTGGCATTCCACCCATCACAACCCGGGCCCTGTGGCCGCCCGACCCCCAAGCTGCCTTCTCCTATGAGGAGACAGCCAAGCT
GGCAGTGGGCCGCCTCTCCGAGTACAGCCACCACTTCGTGAGTGCCTTTGCACGTGGGGCCAGCGCCTACTTCCTGTTCCTGCGGCGGGA
CCTGCAGGCTCAGTCTAGAGCTTTTCGTGCCTATGTATCTCGAGTGTGTCTCCGGGACCAGCACTACTACTCCTATGTGGAGTTGCCTCT
GGCCTGCGAAGGTGGCCGCTACGGGCTGATCCAGGCTGCAGCTGTGGCCACGTCCAGGGAGGTGGCGCATGGGGAGGTGCTCTTTGCAGC
TTTCTCCTCGGCTGCACCCCCCACTGTGGGCCGGCCCCCATCGGCGGCTGCTGGGGCATCTGGAGCCTCTGCCCTCTGTGCCTTCCCCCT
GGATGAGGTGGACCGGCTTGCTAATCGCACGCGAGATGCCTGCTACACCCGGGAGGGTCGTGCTGAGGATGGGACCGAGGTGGCCTACAT
CGAGTATGATGTCAATTCTGACTGTGCACAGCTGCCAGTGGACACCCTGGATGCTTATCCCTGTGGCTCAGACCACACGCCCAGCCCCAT
GGCCAGCCGGGTCCCGCTGGAAGCCACACCAATTCTGGAGTGGCCAGGGATTCAGCTAACAGCTGTGGCAGTCACCATGGAAGATGGACA
CACCATCGCTTTCCTGGGTGATAGTCAAGGGCAGCTGCACAGGGTCTACTTGGGCCCAGGGAGCGATGGCCACCCATACTCCACACAGAG
CATCCAGCAGGGGTCTGCAGTGAGCAGAGACCTCACCTTTGATGGGACCTTTGAGCACCTGTATGTCATGACCCAGAGCACACTTCTGAA
GGTTCCTGTGGCTTCCTGTGCTCAGCACCTGGACTGTGCATCTTGCCTTGCTCACAGGGACCCATACTGTGGGTGGTGCGTGCTCCTTGG
CAGGTGCAGTCGCCGTTCTGAGTGCTCGAGGGGCCAGGGCCCAGAGCAGTGGCTATGGAGCTTCCAGCCTGAGCTGGGCTGTCTGCAAGT
GGCAGCCATGAGTCCTGCCAACATCAGCCGAGAGGAGACGAGGGAGGTTTTCCTATCAGTGCCAGACCTGCCACCCCTGTGGCCAGGGGA
GTCATATTCCTGCCACTTTGGGGAACATCAGAGTCCTGCCCTGCTGACTGGTTCTGGTGTGATGTGCCCCTCCCCAGACCCTAGTGAGGC
CCCAGTGCTGCCGAGAGGAGCCGACTACGTATCCGTGAGCGTGGAGCTCAGATTTGGCGCTGTTGTGATCGCCAAAACTTCCCTCTCTTT
CTATGACTGTGTGGCGGTCACTGAACTCCGCCCATCTGCGCAGTGCCAGGCCTGTGTGAGCAGCCGCTGGGGGTGTAACTGGTGTGTCTG
GCAGCACCTGTGCACCCACAAGGCCTCGTGTGATGCTGGGCCCATGGTTGCAAGCCATCAGAGCCCGCTTGTCTCCCCAGACCCTCCTGC
AAGAGGTGGACCCAGCCCCTCCCCACCCACAGCCCCCAAAGCCCTGGCCACCCCTGCTCCTGACACCCTTCCCGTGGAGCCTGGGGCTCC
CTCCACAGCCACAGCTTCGGACATCTCACCTGGGGCTAGTCCTTCCCTGCTCAGCCCCTGGGGGCCATGGGCAGGTTCTGGCTCCATATC
TTCCCCTGGCTCCACAGGGTCGCCTCTCCATGAGGAGCCCTCCCCTCCCAGCCCCCAAAATGGACCTGGAACCGCTGTCCCTGCCCCCAC
TGACTTCAGACCCTCAGCCACACCTGAGGACCTCTTGGCCTCCCCGCTGTCACCGTCAGAGGTAGCAGCAGTGCCCCCTGCAGACCCTGG
CCCCGAGGCTCTTCATCCCACAGTGCCCCTGGACCTGCCCCCTGCCACTGTTCCTGCCACCACTTTCCCAGGGGCCATGGGCTCCGTGAA
GCCCGCCCTGGACTGGCTCACGAGAGAAGGCGGCGAGCTGCCCGAGGCGGACGAGTGGACGGGGGGTGACGCACCCGCCTTCTCCACTTC
CACCCTCCTCTCAGGTGATGGAGACTCAGCAGAGCTTGAGGGCCCTCCCGCCCCCCTCATCCTCCCGTCCAGCCTCGACTACCAGTATGA
CACCCCCGGGCTCTGGGAGCTGGAAGAGGCGACCTTGGGGGCAAGCTCCTGCCCCTGTGTGGAGAGCGTTCAGGGCTCCACGTTGATGCC
GGTCCATGTGGAGCGGGAAATCCGGCTGCTAGGCAGGAACCTGCACCTTTTCCAGGATGGCCCAGGAGACAATGAGTGTGTGATGGAGCT
GGAGGGCCTCGAGGTGGTGGTTGAGGCCCGGGTCGAGTGTGAGCCACCTCCAGATACCCAGTGCCATGTCACCTGCCAGCAGCACCAGCT
CAGCTATGAGGCTCTGCAGCCGGAGCTCCGTGTGGGGCTGTTTCTGCGTCGGGCCGGCCGTCTGCGTGTGGACAGTGCTGAGGGGCTGCA
TGTGGTACTGTATGACTGTTCCGTGGGACATGGAGACTGCAGCCGCTGCCAAACTGCCATGCCCCAGTATGGCTGTGTGTGGTGTGAGGG
GGAGCGTCCACGTTGTGTGACCCGGGAGGCCTGTGGTGAGGCTGAGGCTGTGGCCACCCAGTGCCCAGCGCCCCTCATCCACTCGGTGGA
GCCACTGACTGGGCCTGTAGACGGAGGCACCCGTGTCACCATCAGGGGCTCCAACCTGGGCCAGCATGTGCAGGATGTGCTGGGCATGGT
CACGGTGGCTGGAGTGCCCTGTGCTGTGGATGCCCAGGAGTACGAGGTCTCCAGCAGCCTCGTGTGCATCACCGGGGCCAGTGGGGAGGA
GGTGGCCGGCGCCACAGCGGTGGAGGTGCCGGGAAGAGGACGTGGTGTCTCAGAACACGACTTTGCCTACCAGGATCCGAAGGTCCATTC
CATCTTCCCGGCCCGCGGCCCCAGAGCTGGGGGCACCCGTCTCACCCTGAATGGCTCCAAGCTCCTGACTGGGCGGCTGGAGGACATCCG
AGTGGTGGTTGGAGACCAGCCTTGTCACTTGCTGCCGGAGCAGCAGTCAGAACAACTGCGGTGTGAGACCAGCCCACGCCCCACGCCTGC
CACGCTCCCTGTGGCTGTGTGGTTTGGGGCCACGGAGCGGAGGCTTCAACGCGGACAGTTCAAGTATACCTTGGACCCCAACATCACCTC
TGCTGGCCCCACCAAGAGCTTCCTCAGTGGAGGACGTGAGATATGCGTCCGTGGCCAGAATCTGGACGTGGTACAGACGCCAAGAATCCG
GGTGACCGTGGTCTCGAGAATGCTGCAGCCCAGCCAGGGGCTTGGACGGAGGCGTCGCGTGGTCCCGGAGACGGCATGTTCCCTTGGACC
CTCCTGCAGTAGCCAGCAATTTGAGGAGCCGTGCCATGTCAACTCCTCCCAGCTCATCACGTGCCGCACACCTGCCCTCCCAGGCCTGCC
TGAGGACCCCTGGGTCCGGGTGGAATTTATCCTTGACAACCTGGTCTTTGACTTTGCAACACTGAACCCCACACCTTTCTCCTATGAGGC
CGACCCCACCCTGCAGCCACTCAACCCTGAGGACCCCACCATGCCATTCCGGCACAAGCCTGGGAGTGTGTTCTCCGTGGAGGGGGAGAA
CCTGGACCTTGCAATGTCCAAGGAGGAGGTGGTGGCTATGATAGGGGATGGCCCCTGTGTGGTGAAGACGCTGACGCGGCACCACCTGTA
CTGCGAGCCCCCCGTGGAGCAGCCCCTGCCACGGCACCATGCCCTCCGAGAGGCACCTGACTCTTTGCCTGAGTTCACGGTGCAGATGGG
GAACTTGCGCTTCTCCCTGGGTCACGTGCAGTATGACGGCGAGAGCCCTGGGGCTTTTCCTGTGGCAGCCCAGGTGGGCTTGGGGGTGGG
CACCTCTCTTCTGGCTCTGGGTGTCATCATCATTGTCCTCATGTACAGGAGGAAGAGCAAGCAGGCCCTGAGGGACTATAAGAAGGTTCA
GATCCAGCTGGAGAATCTGGAGAGCAGTGTGCGGGACCGCTGCAAGAAGGAATTCACAGACCTCATGACTGAGATGACCGATCTCACCAG
TGACCTCCTGGGCAGCGGCATCCCCTTCCTCGACTACAAGGTGTATGCGGAGAGGATCTTCTTCCCTGGGCACCGCGAGTCGCCCTTGCA
CCGGGACCTGGGTGTGCCTGAGAGCAGACGGCCCACTGTGGAGCAAGGGCTGGGGCAGCTCTCTAACCTGCTCAACAGCAAGCTCTTCCT
CACCAAGTTCATCCACACGCTGGAGAGCCAGCGCACCTTTTCAGCTCGGGACCGTGCCTACGTGGCATCTCTGCTCACCGTGGCACTGCA
TGGGAAGCTTGAGTATTTCACTGACATCCTCCGCACTCTGCTCAGTGACCTGGTTGCCCAGTATGTGGCCAAGAACCCCAAGCTGATGCT
GCGCAGGACAGAGACTGTGGTGGAGAAGCTGCTCACCAACTGGATGTCCATCTGTCTGTATACCTTCGTGAGGGACTCCGTAGGGGAGCC
TCTGTACATGCTCTTTCGAGGGATTAAGCACCAAGTGGATAAGGGGCCAGTGGACAGTGTGACAGGCAAGGCCAAATACACCTTGAACGA
CAACCGCCTGCTCAGAGAGGATGTGGAGTACCGTCCCCTGACCTTGAATGCACTATTGGCTGTGGGGCCTGGGGCAGGAGAGGCCCAGGG
CGTGCCCGTGAAGGTCCTAGACTGTGACACCATCTCCCAGGCAAAGGAGAAGATGCTGGACCAGCTTTATAAAGGAGTGCCTCTCACCCA
GCGGCCAGACCCTCGCACCCTTGATGTTGAGTGGCGGTCTGGGGTGGCCGGGCACCTCATTCTTTCTGACGAGGATGTCACTTCTGAGGT
CCAGGGTCTGTGGAGGCGCCTGAACACACTGCAGCATTACAAGGTCCCAGATGGAGCAACTGTGGCCCTCGTCCCCTGCCTCACCAAGCA
TGTGCTCCGGGAAAACCAGGATTATGTCCCTGGAGAGCGGACCCCAATGCTGGAGGATGTAGATGAGGGGGGCATCCGGCCCTGGCACCT
GGTGAAGCCAAGTGATGAGCCGGAGCCGCCCAGGCCTCGGAGGGGCAGCCTTCGGGGCGGGGAGCGTGAGCGCGCCAAGGCCATCCCTGA
GATCTACCTGACCCGCCTGCTGTCCATGAAGGGCACCCTGCAGAAGTTCGTGGATGACCTGTTCCAGGTGATTCTCAGCACCAGCCGCCC
CGTGCCGCTCGCTGTGAAGTACTTCTTTGACCTGCTGGATGAGCAGGCCCAGCAGCATGGCATCTCCGACCAGGACACCATCCACATCTG
GAAGACCAACAGTCTGCTGCTGCGGTTCTGGGTGAATGCCTTGAAGAACCCACAGCTCATCTTTGATGTACGGGTGTCGGACAATGTGGA
CGCCATCCTTGCTGTCATCGCCCAGACCTTCATTGACTCCTGTACCACCTCGGAGCATAAAGTGGGCCGGGATTCCCCAGTGAACAAACT
GCTCTACGCCCGGGAGATCCCACGCTACAAGCAGATGGTGGAGAGGTACTATGCGGACATTCGCCAGAGCTCTCCGGCGAGCTACCAGGA
GATGAACTCTGCTTTGGCTGAGCTCTCCGGGAACTACACTTCTGCTCCCCACTGTCTGGAGGCTCTGCAAGAACTCTACAACCACATCCA
CAGGTACTATGATCAGATTATCAGTGCCCTGGAGGAGGACCCTGTGGGCCAGAAGCTGCAGCTGGCCTGCCGCCTGCAGCAGGTCGCCGC
CCTGGTGGAAAACAAAGTGACTGACCTGTGAGCTCTGGCTCAGACAGCAGCAAGCCGGATCCACCAACACCGCAGCGCCTTATGACCCCG
GAACCGAGCCAGCCACTGAGGGGAGCTGGCAGAGCCTGGGGGCACAGGGTGCAAAGCCAGGCACTGTGCCCAGCAGTGGGCTCCCTGCCT
GCCACCTCCCCTGCCAGCCCACCCACCTTCCCCCCACCTGAGATTGTTTCTAATTTATAAGGATCCCCCTCCTTCCCCCTCTCCCCATTG

>66555_66555_2_PLXNB1-PLXNB3_PLXNB1_chr3_48450978_ENST00000296440_PLXNB3_chrX_153043402_ENST00000538966_length(amino acids)=2135AA_BP=32
MPALGPALLQALWAGWVLTLQPLPPTAFTPNGTYLQHLARDPTSGTLYLGATNFLFQLSPGLQLEATVSTGPVLDSRDCLPPVMPDECPQ
AQPTNNPNQLLLVSPGALVVCGSVHQGVCEQRRLGQLEQLLLRPERPGDTQYVAANDPAVSTVGLVAQGLAGEPLLFVGRGYTSRGVGGG
IPPITTRALWPPDPQAAFSYEETAKLAVGRLSEYSHHFVSAFARGASAYFLFLRRDLQAQSRAFRAYVSRVCLRDQHYYSYVELPLACEG
GRYGLIQAAAVATSREVAHGEVLFAAFSSAAPPTVGRPPSAAAGASGASALCAFPLDEVDRLANRTRDACYTREGRAEDGTEVAYIEYDV
NSDCAQLPVDTLDAYPCGSDHTPSPMASRVPLEATPILEWPGIQLTAVAVTMEDGHTIAFLGDSQGQLHRVYLGPGSDGHPYSTQSIQQG
SAVSRDLTFDGTFEHLYVMTQSTLLKVPVASCAQHLDCASCLAHRDPYCGWCVLLGRCSRRSECSRGQGPEQWLWSFQPELGCLQVAAMS
PANISREETREVFLSVPDLPPLWPGESYSCHFGEHQSPALLTGSGVMCPSPDPSEAPVLPRGADYVSVSVELRFGAVVIAKTSLSFYDCV
AVTELRPSAQCQACVSSRWGCNWCVWQHLCTHKASCDAGPMVASHQSPLVSPDPPARGGPSPSPPTAPKALATPAPDTLPVEPGAPSTAT
ASDISPGASPSLLSPWGPWAGSGSISSPGSTGSPLHEEPSPPSPQNGPGTAVPAPTDFRPSATPEDLLASPLSPSEVAAVPPADPGPEAL
HPTVPLDLPPATVPATTFPGAMGSVKPALDWLTREGGELPEADEWTGGDAPAFSTSTLLSGDGDSAELEGPPAPLILPSSLDYQYDTPGL
WELEEATLGASSCPCVESVQGSTLMPVHVEREIRLLGRNLHLFQDGPGDNECVMELEGLEVVVEARVECEPPPDTQCHVTCQQHQLSYEA
LQPELRVGLFLRRAGRLRVDSAEGLHVVLYDCSVGHGDCSRCQTAMPQYGCVWCEGERPRCVTREACGEAEAVATQCPAPLIHSVEPLTG
PVDGGTRVTIRGSNLGQHVQDVLGMVTVAGVPCAVDAQEYEVSSSLVCITGASGEEVAGATAVEVPGRGRGVSEHDFAYQDPKVHSIFPA
RGPRAGGTRLTLNGSKLLTGRLEDIRVVVGDQPCHLLPEQQSEQLRCETSPRPTPATLPVAVWFGATERRLQRGQFKYTLDPNITSAGPT
KSFLSGGREICVRGQNLDVVQTPRIRVTVVSRMLQPSQGLGRRRRVVPETACSLGPSCSSQQFEEPCHVNSSQLITCRTPALPGLPEDPW
VRVEFILDNLVFDFATLNPTPFSYEADPTLQPLNPEDPTMPFRHKPGSVFSVEGENLDLAMSKEEVVAMIGDGPCVVKTLTRHHLYCEPP
VEQPLPRHHALREAPDSLPEFTVQMGNLRFSLGHVQYDGESPGAFPVAAQVGLGVGTSLLALGVIIIVLMYRRKSKQALRDYKKVQIQLE
NLESSVRDRCKKEFTDLMTEMTDLTSDLLGSGIPFLDYKVYAERIFFPGHRESPLHRDLGVPESRRPTVEQGLGQLSNLLNSKLFLTKFI
HTLESQRTFSARDRAYVASLLTVALHGKLEYFTDILRTLLSDLVAQYVAKNPKLMLRRTETVVEKLLTNWMSICLYTFVRDSVGEPLYML
FRGIKHQVDKGPVDSVTGKAKYTLNDNRLLREDVEYRPLTLNALLAVGPGAGEAQGVPVKVLDCDTISQAKEKMLDQLYKGVPLTQRPDP
RTLDVEWRSGVAGHLILSDEDVTSEVQGLWRRLNTLQHYKVPDGATVALVPCLTKHVLRENQDYVPGERTPMLEDVDEGGIRPWHLVKPS
DEPEPPRPRRGSLRGGERERAKAIPEIYLTRLLSMKGTLQKFVDDLFQVILSTSRPVPLAVKYFFDLLDEQAQQHGISDQDTIHIWKTNS
LLLRFWVNALKNPQLIFDVRVSDNVDAILAVIAQTFIDSCTTSEHKVGRDSPVNKLLYAREIPRYKQMVERYYADIRQSSPASYQEMNSA

--------------------------------------------------------------
>66555_66555_3_PLXNB1-PLXNB3_PLXNB1_chr3_48450978_ENST00000456774_PLXNB3_chrX_153043402_ENST00000361971_length(transcript)=6161nt_BP=5390nt
ATGCCTGCTCTGGGCCCAGCTCTTCTCCAGGCTCTCTGGGCCGGGTGGGTCCTCACCCTCCAGCCCCTTCCACCAACTGCATTCACTCCC
AATGGCACGTATCTGCAGCACCTGGCAAGGGACCCCACCTCAGGCACCCTCTACCTGGGGGCTACCAACTTCCTGTTCCAGCTGAGCCCT
GGGCTGCAGCTGGAGGCCACAGTGTCCACCGGCCCTGTGCTAGACAGCAGGGACTGCCTGCCACCTGTGATGCCTGATGAGTGCCCCCAG
GCCCAGCCTACCAACAACCCGAATCAGCTGCTCCTGGTGAGCCCAGGGGCCCTGGTGGTATGCGGGAGCGTGCACCAGGGGGTCTGTGAA
CAGCGGCGCCTGGGGCAGCTCGAGCAGCTGCTGCTGCGGCCAGAGCGGCCTGGGGACACACAATATGTGGCTGCCAATGATCCTGCGGTC
AGCACGGTGGGGCTGGTAGCCCAGGGCTTGGCAGGGGAGCCCCTCCTGTTTGTGGGGCGAGGATACACCAGCAGGGGTGTGGGGGGTGGC
ATTCCACCCATCACAACCCGGGCCCTGTGGCCGCCCGACCCCCAAGCTGCCTTCTCCTATGAGGAGACAGCCAAGCTGGCAGTGGGCCGC
CTCTCCGAGTACAGCCACCACTTCGTGAGTGCCTTTGCACGTGGGGCCAGCGCCTACTTCCTGTTCCTGCGGCGGGACCTGCAGGCTCAG
TCTAGAGCTTTTCGTGCCTATGTATCTCGAGTGTGTCTCCGGGACCAGCACTACTACTCCTATGTGGAGTTGCCTCTGGCCTGCGAAGGT
GGCCGCTACGGGCTGATCCAGGCTGCAGCTGTGGCCACGTCCAGGGAGGTGGCGCATGGGGAGGTGCTCTTTGCAGCTTTCTCCTCGGCT
GCACCCCCCACTGTGGGCCGGCCCCCATCGGCGGCTGCTGGGGCATCTGGAGCCTCTGCCCTCTGTGCCTTCCCCCTGGATGAGGTGGAC
CGGCTTGCTAATCGCACGCGAGATGCCTGCTACACCCGGGAGGGTCGTGCTGAGGATGGGACCGAGGTGGCCTACATCGAGTATGATGTC
AATTCTGACTGTGCACAGCTGCCAGTGGACACCCTGGATGCTTATCCCTGTGGCTCAGACCACACGCCCAGCCCCATGGCCAGCCGGGTC
CCGCTGGAAGCCACACCAATTCTGGAGTGGCCAGGGATTCAGCTAACAGCTGTGGCAGTCACCATGGAAGATGGACACACCATCGCTTTC
CTGGGTGATAGTCAAGGGCAGCTGCACAGGGTCTACTTGGGCCCAGGGAGCGATGGCCACCCATACTCCACACAGAGCATCCAGCAGGGG
TCTGCAGTGAGCAGAGACCTCACCTTTGATGGGACCTTTGAGCACCTGTATGTCATGACCCAGAGCACACTTCTGAAGGTTCCTGTGGCT
TCCTGTGCTCAGCACCTGGACTGTGCATCTTGCCTTGCTCACAGGGACCCATACTGTGGGTGGTGCGTGCTCCTTGGCAGGTGCAGTCGC
CGTTCTGAGTGCTCGAGGGGCCAGGGCCCAGAGCAGTGGCTATGGAGCTTCCAGCCTGAGCTGGGCTGTCTGCAAGTGGCAGCCATGAGT
CCTGCCAACATCAGCCGAGAGGAGACGAGGGAGGTTTTCCTATCAGTGCCAGACCTGCCACCCCTGTGGCCAGGGGAGTCATATTCCTGC
CACTTTGGGGAACATCAGAGTCCTGCCCTGCTGACTGGTTCTGGTGTGATGTGCCCCTCCCCAGACCCTAGTGAGGCCCCAGTGCTGCCG
AGAGGAGCCGACTACGTATCCGTGAGCGTGGAGCTCAGATTTGGCGCTGTTGTGATCGCCAAAACTTCCCTCTCTTTCTATGACTGTGTG
GCGGTCACTGAACTCCGCCCATCTGCGCAGTGCCAGGCCTGTGTGAGCAGCCGCTGGGGGTGTAACTGGTGTGTCTGGCAGCACCTGTGC
ACCCACAAGGCCTCGTGTGATGCTGGGCCCATGGTTGCAAGCCATCAGAGCCCGCTTGTCTCCCCAGACCCTCCTGCAAGAGGTGATGGA
GACTCAGCAGAGCTTGAGGGCCCTCCCGCCCCCCTCATCCTCCCGTCCAGCCTCGACTACCAGTATGACACCCCCGGGCTCTGGGAGCTG
GAAGAGGCGACCTTGGGGGCAAGCTCCTGCCCCTGTGTGGAGAGCGTTCAGGGCTCCACGTTGATGCCGGTCCATGTGGAGCGGGAAATC
CGGCTGCTAGGCAGGAACCTGCACCTTTTCCAGGATGGCCCAGGAGACAATGAGTGTGTGATGGAGCTGGAGGGCCTCGAGGTGGTGGTT
GAGGCCCGGGTCGAGTGTGAGCCACCTCCAGATACCCAGTGCCATGTCACCTGCCAGCAGCACCAGCTCAGCTATGAGGCTCTGCAGCCG
GAGCTCCGTGTGGGGCTGTTTCTGCGTCGGGCCGGCCGTCTGCGTGTGGACAGTGCTGAGGGGCTGCATGTGGTACTGTATGACTGTTCC
GTGGGACATGGAGACTGCAGCCGCTGCCAAACTGCCATGCCCCAGTATGGCTGTGTGTGGTGTGAGGGGGAGCGTCCACGTTGTGTGACC
CGGGAGGCCTGTGGTGAGGCTGAGGCTGTGGCCACCCAGTGCCCAGCGCCCCTCATCCACTCGGTGGAGCCACTGACTGGGCCTGTAGAC
GGAGGCACCCGTGTCACCATCAGGGGCTCCAACCTGGGCCAGCATGTGCAGGATGTGCTGGGCATGGTCACGGTGGCTGGAGTGCCCTGT
GCTGTGGATGCCCAGGAGTACGAGGTCTCCAGCAGCCTCGTGTGCATCACCGGGGCCAGTGGGGAGGAGGTGGCCGGCGCCACAGCGGTG
GAGGTGCCGGGAAGAGGACGTGGTGTCTCAGAACACGACTTTGCCTACCAGGATCCGAAGGTCCATTCCATCTTCCCGGCCCGCGGCCCC
AGAGCTGGGGGCACCCGTCTCACCCTGAATGGCTCCAAGCTCCTGACTGGGCGGCTGGAGGACATCCGAGTGGTGGTTGGAGACCAGCCT
TGTCACTTGCTGCCGGAGCAGCAGTCAGAACAACTGCGGTGTGAGACCAGCCCACGCCCCACGCCTGCCACGCTCCCTGTGGCTGTGTGG
TTTGGGGCCACGGAGCGGAGGCTTCAACGCGGACAGTTCAAGTATACCTTGGACCCCAACATCACCTCTGCTGGCCCCACCAAGAGCTTC
CTCAGTGGAGGACGTGAGATATGCGTCCGTGGCCAGAATCTGGACGTGGTACAGACGCCAAGAATCCGGGTGACCGTGGTCTCGAGAATG
CTGCAGCCCAGCCAGGGGCTTGGACGGAGGCGTCGCGTGGTCCCGGAGACGGCATGTTCCCTTGGACCCTCCTGCAGTAGCCAGCAATTT
GAGGAGCCGTGCCATGTCAACTCCTCCCAGCTCATCACGTGCCGCACACCTGCCCTCCCAGGCCTGCCTGAGGACCCCTGGGTCCGGGTG
GAATTTATCCTTGACAACCTGGTCTTTGACTTTGCAACACTGAACCCCACACCTTTCTCCTATGAGGCCGACCCCACCCTGCAGCCACTC
AACCCTGAGGACCCCACCATGCCATTCCGGCACAAGCCTGGGAGTGTGTTCTCCGTGGAGGGGGAGAACCTGGACCTTGCAATGTCCAAG
GAGGAGGTGGTGGCTATGATAGGGGATGGCCCCTGTGTGGTGAAGACGCTGACGCGGCACCACCTGTACTGCGAGCCCCCCGTGGAGCAG
CCCCTGCCACGGCACCATGCCCTCCGAGAGGCACCTGACTCTTTGCCTGAGTTCACGGTGCAGATGGGGAACTTGCGCTTCTCCCTGGGT
CACGTGCAGTATGACGGCGAGAGCCCTGGGGCTTTTCCTGTGGCAGCCCAGGTGGGCTTGGGGGTGGGCACCTCTCTTCTGGCTCTGGGT
GTCATCATCATTGTCCTCATGTACAGGAGGAAGAGCAAGCAGGCCCTGAGGGACTATAAGAAGGTTCAGATCCAGCTGGAGAATCTGGAG
AGCAGTGTGCGGGACCGCTGCAAGAAGGAATTCACAGACCTCATGACTGAGATGACCGATCTCACCAGTGACCTCCTGGGCAGCGGCATC
CCCTTCCTCGACTACAAGGTGTATGCGGAGAGGATCTTCTTCCCTGGGCACCGCGAGTCGCCCTTGCACCGGGACCTGGGTGTGCCTGAG
AGCAGACGGCCCACTGTGGAGCAAGGGCTGGGGCAGCTCTCTAACCTGCTCAACAGCAAGCTCTTCCTCACCAAGTTCATCCACACGCTG
GAGAGCCAGCGCACCTTTTCAGCTCGGGACCGTGCCTACGTGGCATCTCTGCTCACCGTGGCACTGCATGGGAAGCTTGAGTATTTCACT
GACATCCTCCGCACTCTGCTCAGTGACCTGGTTGCCCAGTATGTGGCCAAGAACCCCAAGCTGATGCTGCGCAGGACAGAGACTGTGGTG
GAGAAGCTGCTCACCAACTGGATGTCCATCTGTCTGTATACCTTCGTGAGGGACTCCGTAGGGGAGCCTCTGTACATGCTCTTTCGAGGG
ATTAAGCACCAAGTGGATAAGGGGCCAGTGGACAGTGTGACAGGCAAGGCCAAATACACCTTGAACGACAACCGCCTGCTCAGAGAGGAT
GTGGAGTACCGTCCCCTGACCTTGAATGCACTATTGGCTGTGGGGCCTGGGGCAGGAGAGGCCCAGGGCGTGCCCGTGAAGGTCCTAGAC
TGTGACACCATCTCCCAGGCAAAGGAGAAGATGCTGGACCAGCTTTATAAAGGAGTGCCTCTCACCCAGCGGCCAGACCCTCGCACCCTT
GATGTTGAGTGGCGGTCTGGGGTGGCCGGGCACCTCATTCTTTCTGACGAGGATGTCACTTCTGAGGTCCAGGGTCTGTGGAGGCGCCTG
AACACACTGCAGCATTACAAGGTCCCAGATGGAGCAACTGTGGCCCTCGTCCCCTGCCTCACCAAGCATGTGCTCCGGGAAAACCAGGAT
TATGTCCCTGGAGAGCGGACCCCAATGCTGGAGGATGTAGATGAGGGGGGCATCCGGCCCTGGCACCTGGTGAAGCCAAGTGATGAGCCG
GAGCCGCCCAGGCCTCGGAGGGGCAGCCTTCGGGGCGGGGAGCGTGAGCGCGCCAAGGCCATCCCTGAGATCTACCTGACCCGCCTGCTG
TCCATGAAGGGCACCCTGCAGAAGTTCGTGGATGACCTGTTCCAGGTGATTCTCAGCACCAGCCGCCCCGTGCCGCTCGCTGTGAAGTAC
TTCTTTGACCTGCTGGATGAGCAGGCCCAGCAGCATGGCATCTCCGACCAGGACACCATCCACATCTGGAAGACCAACAGTCTGCTGCTG
CGGTTCTGGGTGAATGCCTTGAAGAACCCACAGCTCATCTTTGATGTACGGGTGTCGGACAATGTGGACGCCATCCTTGCTGTCATCGCC
CAGACCTTCATTGACTCCTGTACCACCTCGGAGCATAAAGTGGGCCGGGATTCCCCAGTGAACAAACTGCTCTACGCCCGGGAGATCCCA
CGCTACAAGCAGATGGTGGAGAGGTACTATGCGGACATTCGCCAGAGCTCTCCGGCGAGCTACCAGGAGATGAACTCTGCTTTGGCTGAG
CTCTCCGGGAACTACACTTCTGCTCCCCACTGTCTGGAGGCTCTGCAAGAACTCTACAACCACATCCACAGGTACTATGATCAGATTATC
AGTGCCCTGGAGGAGGACCCTGTGGGCCAGAAGCTGCAGCTGGCCTGCCGCCTGCAGCAGGTCGCCGCCCTGGTGGAAAACAAAGTGACT
GACCTGTGAGCTCTGGCTCAGACAGCAGCAAGCCGGATCCACCAACACCGCAGCGCCTTATGACCCCGGAACCGAGCCAGCCACTGAGGG
GAGCTGGCAGAGCCTGGGGGCACAGGGTGCAAAGCCAGGCACTGTGCCCAGCAGTGGGCTCCCTGCCTGCCACCTCCCCTGCCAGCCCAC
CCACCTTCCCCCCACCTGAGATTGTTTCTAATTTATAAGGATCCCCCTCCTTCCCCCTCTCCCCATTGTATTTATTTGCCTGCTGGAAAA

>66555_66555_3_PLXNB1-PLXNB3_PLXNB1_chr3_48450978_ENST00000456774_PLXNB3_chrX_153043402_ENST00000361971_length(amino acids)=1952AA_BP=32
MPALGPALLQALWAGWVLTLQPLPPTAFTPNGTYLQHLARDPTSGTLYLGATNFLFQLSPGLQLEATVSTGPVLDSRDCLPPVMPDECPQ
AQPTNNPNQLLLVSPGALVVCGSVHQGVCEQRRLGQLEQLLLRPERPGDTQYVAANDPAVSTVGLVAQGLAGEPLLFVGRGYTSRGVGGG
IPPITTRALWPPDPQAAFSYEETAKLAVGRLSEYSHHFVSAFARGASAYFLFLRRDLQAQSRAFRAYVSRVCLRDQHYYSYVELPLACEG
GRYGLIQAAAVATSREVAHGEVLFAAFSSAAPPTVGRPPSAAAGASGASALCAFPLDEVDRLANRTRDACYTREGRAEDGTEVAYIEYDV
NSDCAQLPVDTLDAYPCGSDHTPSPMASRVPLEATPILEWPGIQLTAVAVTMEDGHTIAFLGDSQGQLHRVYLGPGSDGHPYSTQSIQQG
SAVSRDLTFDGTFEHLYVMTQSTLLKVPVASCAQHLDCASCLAHRDPYCGWCVLLGRCSRRSECSRGQGPEQWLWSFQPELGCLQVAAMS
PANISREETREVFLSVPDLPPLWPGESYSCHFGEHQSPALLTGSGVMCPSPDPSEAPVLPRGADYVSVSVELRFGAVVIAKTSLSFYDCV
AVTELRPSAQCQACVSSRWGCNWCVWQHLCTHKASCDAGPMVASHQSPLVSPDPPARGDGDSAELEGPPAPLILPSSLDYQYDTPGLWEL
EEATLGASSCPCVESVQGSTLMPVHVEREIRLLGRNLHLFQDGPGDNECVMELEGLEVVVEARVECEPPPDTQCHVTCQQHQLSYEALQP
ELRVGLFLRRAGRLRVDSAEGLHVVLYDCSVGHGDCSRCQTAMPQYGCVWCEGERPRCVTREACGEAEAVATQCPAPLIHSVEPLTGPVD
GGTRVTIRGSNLGQHVQDVLGMVTVAGVPCAVDAQEYEVSSSLVCITGASGEEVAGATAVEVPGRGRGVSEHDFAYQDPKVHSIFPARGP
RAGGTRLTLNGSKLLTGRLEDIRVVVGDQPCHLLPEQQSEQLRCETSPRPTPATLPVAVWFGATERRLQRGQFKYTLDPNITSAGPTKSF
LSGGREICVRGQNLDVVQTPRIRVTVVSRMLQPSQGLGRRRRVVPETACSLGPSCSSQQFEEPCHVNSSQLITCRTPALPGLPEDPWVRV
EFILDNLVFDFATLNPTPFSYEADPTLQPLNPEDPTMPFRHKPGSVFSVEGENLDLAMSKEEVVAMIGDGPCVVKTLTRHHLYCEPPVEQ
PLPRHHALREAPDSLPEFTVQMGNLRFSLGHVQYDGESPGAFPVAAQVGLGVGTSLLALGVIIIVLMYRRKSKQALRDYKKVQIQLENLE
SSVRDRCKKEFTDLMTEMTDLTSDLLGSGIPFLDYKVYAERIFFPGHRESPLHRDLGVPESRRPTVEQGLGQLSNLLNSKLFLTKFIHTL
ESQRTFSARDRAYVASLLTVALHGKLEYFTDILRTLLSDLVAQYVAKNPKLMLRRTETVVEKLLTNWMSICLYTFVRDSVGEPLYMLFRG
IKHQVDKGPVDSVTGKAKYTLNDNRLLREDVEYRPLTLNALLAVGPGAGEAQGVPVKVLDCDTISQAKEKMLDQLYKGVPLTQRPDPRTL
DVEWRSGVAGHLILSDEDVTSEVQGLWRRLNTLQHYKVPDGATVALVPCLTKHVLRENQDYVPGERTPMLEDVDEGGIRPWHLVKPSDEP
EPPRPRRGSLRGGERERAKAIPEIYLTRLLSMKGTLQKFVDDLFQVILSTSRPVPLAVKYFFDLLDEQAQQHGISDQDTIHIWKTNSLLL
RFWVNALKNPQLIFDVRVSDNVDAILAVIAQTFIDSCTTSEHKVGRDSPVNKLLYAREIPRYKQMVERYYADIRQSSPASYQEMNSALAE

--------------------------------------------------------------
>66555_66555_4_PLXNB1-PLXNB3_PLXNB1_chr3_48450978_ENST00000456774_PLXNB3_chrX_153043402_ENST00000538966_length(transcript)=6166nt_BP=5390nt
ATGCCTGCTCTGGGCCCAGCTCTTCTCCAGGCTCTCTGGGCCGGGTGGGTCCTCACCCTCCAGCCCCTTCCACCAACTGCATTCACTCCC
AATGGCACGTATCTGCAGCACCTGGCAAGGGACCCCACCTCAGGCACCCTCTACCTGGGGGCTACCAACTTCCTGTTCCAGCTGAGCCCT
GGGCTGCAGCTGGAGGCCACAGTGTCCACCGGCCCTGTGCTAGACAGCAGGGACTGCCTGCCACCTGTGATGCCTGATGAGTGCCCCCAG
GCCCAGCCTACCAACAACCCGAATCAGCTGCTCCTGGTGAGCCCAGGGGCCCTGGTGGTATGCGGGAGCGTGCACCAGGGGGTCTGTGAA
CAGCGGCGCCTGGGGCAGCTCGAGCAGCTGCTGCTGCGGCCAGAGCGGCCTGGGGACACACAATATGTGGCTGCCAATGATCCTGCGGTC
AGCACGGTGGGGCTGGTAGCCCAGGGCTTGGCAGGGGAGCCCCTCCTGTTTGTGGGGCGAGGATACACCAGCAGGGGTGTGGGGGGTGGC
ATTCCACCCATCACAACCCGGGCCCTGTGGCCGCCCGACCCCCAAGCTGCCTTCTCCTATGAGGAGACAGCCAAGCTGGCAGTGGGCCGC
CTCTCCGAGTACAGCCACCACTTCGTGAGTGCCTTTGCACGTGGGGCCAGCGCCTACTTCCTGTTCCTGCGGCGGGACCTGCAGGCTCAG
TCTAGAGCTTTTCGTGCCTATGTATCTCGAGTGTGTCTCCGGGACCAGCACTACTACTCCTATGTGGAGTTGCCTCTGGCCTGCGAAGGT
GGCCGCTACGGGCTGATCCAGGCTGCAGCTGTGGCCACGTCCAGGGAGGTGGCGCATGGGGAGGTGCTCTTTGCAGCTTTCTCCTCGGCT
GCACCCCCCACTGTGGGCCGGCCCCCATCGGCGGCTGCTGGGGCATCTGGAGCCTCTGCCCTCTGTGCCTTCCCCCTGGATGAGGTGGAC
CGGCTTGCTAATCGCACGCGAGATGCCTGCTACACCCGGGAGGGTCGTGCTGAGGATGGGACCGAGGTGGCCTACATCGAGTATGATGTC
AATTCTGACTGTGCACAGCTGCCAGTGGACACCCTGGATGCTTATCCCTGTGGCTCAGACCACACGCCCAGCCCCATGGCCAGCCGGGTC
CCGCTGGAAGCCACACCAATTCTGGAGTGGCCAGGGATTCAGCTAACAGCTGTGGCAGTCACCATGGAAGATGGACACACCATCGCTTTC
CTGGGTGATAGTCAAGGGCAGCTGCACAGGGTCTACTTGGGCCCAGGGAGCGATGGCCACCCATACTCCACACAGAGCATCCAGCAGGGG
TCTGCAGTGAGCAGAGACCTCACCTTTGATGGGACCTTTGAGCACCTGTATGTCATGACCCAGAGCACACTTCTGAAGGTTCCTGTGGCT
TCCTGTGCTCAGCACCTGGACTGTGCATCTTGCCTTGCTCACAGGGACCCATACTGTGGGTGGTGCGTGCTCCTTGGCAGGTGCAGTCGC
CGTTCTGAGTGCTCGAGGGGCCAGGGCCCAGAGCAGTGGCTATGGAGCTTCCAGCCTGAGCTGGGCTGTCTGCAAGTGGCAGCCATGAGT
CCTGCCAACATCAGCCGAGAGGAGACGAGGGAGGTTTTCCTATCAGTGCCAGACCTGCCACCCCTGTGGCCAGGGGAGTCATATTCCTGC
CACTTTGGGGAACATCAGAGTCCTGCCCTGCTGACTGGTTCTGGTGTGATGTGCCCCTCCCCAGACCCTAGTGAGGCCCCAGTGCTGCCG
AGAGGAGCCGACTACGTATCCGTGAGCGTGGAGCTCAGATTTGGCGCTGTTGTGATCGCCAAAACTTCCCTCTCTTTCTATGACTGTGTG
GCGGTCACTGAACTCCGCCCATCTGCGCAGTGCCAGGCCTGTGTGAGCAGCCGCTGGGGGTGTAACTGGTGTGTCTGGCAGCACCTGTGC
ACCCACAAGGCCTCGTGTGATGCTGGGCCCATGGTTGCAAGCCATCAGAGCCCGCTTGTCTCCCCAGACCCTCCTGCAAGAGGTGATGGA
GACTCAGCAGAGCTTGAGGGCCCTCCCGCCCCCCTCATCCTCCCGTCCAGCCTCGACTACCAGTATGACACCCCCGGGCTCTGGGAGCTG
GAAGAGGCGACCTTGGGGGCAAGCTCCTGCCCCTGTGTGGAGAGCGTTCAGGGCTCCACGTTGATGCCGGTCCATGTGGAGCGGGAAATC
CGGCTGCTAGGCAGGAACCTGCACCTTTTCCAGGATGGCCCAGGAGACAATGAGTGTGTGATGGAGCTGGAGGGCCTCGAGGTGGTGGTT
GAGGCCCGGGTCGAGTGTGAGCCACCTCCAGATACCCAGTGCCATGTCACCTGCCAGCAGCACCAGCTCAGCTATGAGGCTCTGCAGCCG
GAGCTCCGTGTGGGGCTGTTTCTGCGTCGGGCCGGCCGTCTGCGTGTGGACAGTGCTGAGGGGCTGCATGTGGTACTGTATGACTGTTCC
GTGGGACATGGAGACTGCAGCCGCTGCCAAACTGCCATGCCCCAGTATGGCTGTGTGTGGTGTGAGGGGGAGCGTCCACGTTGTGTGACC
CGGGAGGCCTGTGGTGAGGCTGAGGCTGTGGCCACCCAGTGCCCAGCGCCCCTCATCCACTCGGTGGAGCCACTGACTGGGCCTGTAGAC
GGAGGCACCCGTGTCACCATCAGGGGCTCCAACCTGGGCCAGCATGTGCAGGATGTGCTGGGCATGGTCACGGTGGCTGGAGTGCCCTGT
GCTGTGGATGCCCAGGAGTACGAGGTCTCCAGCAGCCTCGTGTGCATCACCGGGGCCAGTGGGGAGGAGGTGGCCGGCGCCACAGCGGTG
GAGGTGCCGGGAAGAGGACGTGGTGTCTCAGAACACGACTTTGCCTACCAGGATCCGAAGGTCCATTCCATCTTCCCGGCCCGCGGCCCC
AGAGCTGGGGGCACCCGTCTCACCCTGAATGGCTCCAAGCTCCTGACTGGGCGGCTGGAGGACATCCGAGTGGTGGTTGGAGACCAGCCT
TGTCACTTGCTGCCGGAGCAGCAGTCAGAACAACTGCGGTGTGAGACCAGCCCACGCCCCACGCCTGCCACGCTCCCTGTGGCTGTGTGG
TTTGGGGCCACGGAGCGGAGGCTTCAACGCGGACAGTTCAAGTATACCTTGGACCCCAACATCACCTCTGCTGGCCCCACCAAGAGCTTC
CTCAGTGGAGGACGTGAGATATGCGTCCGTGGCCAGAATCTGGACGTGGTACAGACGCCAAGAATCCGGGTGACCGTGGTCTCGAGAATG
CTGCAGCCCAGCCAGGGGCTTGGACGGAGGCGTCGCGTGGTCCCGGAGACGGCATGTTCCCTTGGACCCTCCTGCAGTAGCCAGCAATTT
GAGGAGCCGTGCCATGTCAACTCCTCCCAGCTCATCACGTGCCGCACACCTGCCCTCCCAGGCCTGCCTGAGGACCCCTGGGTCCGGGTG
GAATTTATCCTTGACAACCTGGTCTTTGACTTTGCAACACTGAACCCCACACCTTTCTCCTATGAGGCCGACCCCACCCTGCAGCCACTC
AACCCTGAGGACCCCACCATGCCATTCCGGCACAAGCCTGGGAGTGTGTTCTCCGTGGAGGGGGAGAACCTGGACCTTGCAATGTCCAAG
GAGGAGGTGGTGGCTATGATAGGGGATGGCCCCTGTGTGGTGAAGACGCTGACGCGGCACCACCTGTACTGCGAGCCCCCCGTGGAGCAG
CCCCTGCCACGGCACCATGCCCTCCGAGAGGCACCTGACTCTTTGCCTGAGTTCACGGTGCAGATGGGGAACTTGCGCTTCTCCCTGGGT
CACGTGCAGTATGACGGCGAGAGCCCTGGGGCTTTTCCTGTGGCAGCCCAGGTGGGCTTGGGGGTGGGCACCTCTCTTCTGGCTCTGGGT
GTCATCATCATTGTCCTCATGTACAGGAGGAAGAGCAAGCAGGCCCTGAGGGACTATAAGAAGGTTCAGATCCAGCTGGAGAATCTGGAG
AGCAGTGTGCGGGACCGCTGCAAGAAGGAATTCACAGACCTCATGACTGAGATGACCGATCTCACCAGTGACCTCCTGGGCAGCGGCATC
CCCTTCCTCGACTACAAGGTGTATGCGGAGAGGATCTTCTTCCCTGGGCACCGCGAGTCGCCCTTGCACCGGGACCTGGGTGTGCCTGAG
AGCAGACGGCCCACTGTGGAGCAAGGGCTGGGGCAGCTCTCTAACCTGCTCAACAGCAAGCTCTTCCTCACCAAGTTCATCCACACGCTG
GAGAGCCAGCGCACCTTTTCAGCTCGGGACCGTGCCTACGTGGCATCTCTGCTCACCGTGGCACTGCATGGGAAGCTTGAGTATTTCACT
GACATCCTCCGCACTCTGCTCAGTGACCTGGTTGCCCAGTATGTGGCCAAGAACCCCAAGCTGATGCTGCGCAGGACAGAGACTGTGGTG
GAGAAGCTGCTCACCAACTGGATGTCCATCTGTCTGTATACCTTCGTGAGGGACTCCGTAGGGGAGCCTCTGTACATGCTCTTTCGAGGG
ATTAAGCACCAAGTGGATAAGGGGCCAGTGGACAGTGTGACAGGCAAGGCCAAATACACCTTGAACGACAACCGCCTGCTCAGAGAGGAT
GTGGAGTACCGTCCCCTGACCTTGAATGCACTATTGGCTGTGGGGCCTGGGGCAGGAGAGGCCCAGGGCGTGCCCGTGAAGGTCCTAGAC
TGTGACACCATCTCCCAGGCAAAGGAGAAGATGCTGGACCAGCTTTATAAAGGAGTGCCTCTCACCCAGCGGCCAGACCCTCGCACCCTT
GATGTTGAGTGGCGGTCTGGGGTGGCCGGGCACCTCATTCTTTCTGACGAGGATGTCACTTCTGAGGTCCAGGGTCTGTGGAGGCGCCTG
AACACACTGCAGCATTACAAGGTCCCAGATGGAGCAACTGTGGCCCTCGTCCCCTGCCTCACCAAGCATGTGCTCCGGGAAAACCAGGAT
TATGTCCCTGGAGAGCGGACCCCAATGCTGGAGGATGTAGATGAGGGGGGCATCCGGCCCTGGCACCTGGTGAAGCCAAGTGATGAGCCG
GAGCCGCCCAGGCCTCGGAGGGGCAGCCTTCGGGGCGGGGAGCGTGAGCGCGCCAAGGCCATCCCTGAGATCTACCTGACCCGCCTGCTG
TCCATGAAGGGCACCCTGCAGAAGTTCGTGGATGACCTGTTCCAGGTGATTCTCAGCACCAGCCGCCCCGTGCCGCTCGCTGTGAAGTAC
TTCTTTGACCTGCTGGATGAGCAGGCCCAGCAGCATGGCATCTCCGACCAGGACACCATCCACATCTGGAAGACCAACAGTCTGCTGCTG
CGGTTCTGGGTGAATGCCTTGAAGAACCCACAGCTCATCTTTGATGTACGGGTGTCGGACAATGTGGACGCCATCCTTGCTGTCATCGCC
CAGACCTTCATTGACTCCTGTACCACCTCGGAGCATAAAGTGGGCCGGGATTCCCCAGTGAACAAACTGCTCTACGCCCGGGAGATCCCA
CGCTACAAGCAGATGGTGGAGAGGTACTATGCGGACATTCGCCAGAGCTCTCCGGCGAGCTACCAGGAGATGAACTCTGCTTTGGCTGAG
CTCTCCGGGAACTACACTTCTGCTCCCCACTGTCTGGAGGCTCTGCAAGAACTCTACAACCACATCCACAGGTACTATGATCAGATTATC
AGTGCCCTGGAGGAGGACCCTGTGGGCCAGAAGCTGCAGCTGGCCTGCCGCCTGCAGCAGGTCGCCGCCCTGGTGGAAAACAAAGTGACT
GACCTGTGAGCTCTGGCTCAGACAGCAGCAAGCCGGATCCACCAACACCGCAGCGCCTTATGACCCCGGAACCGAGCCAGCCACTGAGGG
GAGCTGGCAGAGCCTGGGGGCACAGGGTGCAAAGCCAGGCACTGTGCCCAGCAGTGGGCTCCCTGCCTGCCACCTCCCCTGCCAGCCCAC
CCACCTTCCCCCCACCTGAGATTGTTTCTAATTTATAAGGATCCCCCTCCTTCCCCCTCTCCCCATTGTATTTATTTGCCTGCTGGAAAA

>66555_66555_4_PLXNB1-PLXNB3_PLXNB1_chr3_48450978_ENST00000456774_PLXNB3_chrX_153043402_ENST00000538966_length(amino acids)=1952AA_BP=32
MPALGPALLQALWAGWVLTLQPLPPTAFTPNGTYLQHLARDPTSGTLYLGATNFLFQLSPGLQLEATVSTGPVLDSRDCLPPVMPDECPQ
AQPTNNPNQLLLVSPGALVVCGSVHQGVCEQRRLGQLEQLLLRPERPGDTQYVAANDPAVSTVGLVAQGLAGEPLLFVGRGYTSRGVGGG
IPPITTRALWPPDPQAAFSYEETAKLAVGRLSEYSHHFVSAFARGASAYFLFLRRDLQAQSRAFRAYVSRVCLRDQHYYSYVELPLACEG
GRYGLIQAAAVATSREVAHGEVLFAAFSSAAPPTVGRPPSAAAGASGASALCAFPLDEVDRLANRTRDACYTREGRAEDGTEVAYIEYDV
NSDCAQLPVDTLDAYPCGSDHTPSPMASRVPLEATPILEWPGIQLTAVAVTMEDGHTIAFLGDSQGQLHRVYLGPGSDGHPYSTQSIQQG
SAVSRDLTFDGTFEHLYVMTQSTLLKVPVASCAQHLDCASCLAHRDPYCGWCVLLGRCSRRSECSRGQGPEQWLWSFQPELGCLQVAAMS
PANISREETREVFLSVPDLPPLWPGESYSCHFGEHQSPALLTGSGVMCPSPDPSEAPVLPRGADYVSVSVELRFGAVVIAKTSLSFYDCV
AVTELRPSAQCQACVSSRWGCNWCVWQHLCTHKASCDAGPMVASHQSPLVSPDPPARGDGDSAELEGPPAPLILPSSLDYQYDTPGLWEL
EEATLGASSCPCVESVQGSTLMPVHVEREIRLLGRNLHLFQDGPGDNECVMELEGLEVVVEARVECEPPPDTQCHVTCQQHQLSYEALQP
ELRVGLFLRRAGRLRVDSAEGLHVVLYDCSVGHGDCSRCQTAMPQYGCVWCEGERPRCVTREACGEAEAVATQCPAPLIHSVEPLTGPVD
GGTRVTIRGSNLGQHVQDVLGMVTVAGVPCAVDAQEYEVSSSLVCITGASGEEVAGATAVEVPGRGRGVSEHDFAYQDPKVHSIFPARGP
RAGGTRLTLNGSKLLTGRLEDIRVVVGDQPCHLLPEQQSEQLRCETSPRPTPATLPVAVWFGATERRLQRGQFKYTLDPNITSAGPTKSF
LSGGREICVRGQNLDVVQTPRIRVTVVSRMLQPSQGLGRRRRVVPETACSLGPSCSSQQFEEPCHVNSSQLITCRTPALPGLPEDPWVRV
EFILDNLVFDFATLNPTPFSYEADPTLQPLNPEDPTMPFRHKPGSVFSVEGENLDLAMSKEEVVAMIGDGPCVVKTLTRHHLYCEPPVEQ
PLPRHHALREAPDSLPEFTVQMGNLRFSLGHVQYDGESPGAFPVAAQVGLGVGTSLLALGVIIIVLMYRRKSKQALRDYKKVQIQLENLE
SSVRDRCKKEFTDLMTEMTDLTSDLLGSGIPFLDYKVYAERIFFPGHRESPLHRDLGVPESRRPTVEQGLGQLSNLLNSKLFLTKFIHTL
ESQRTFSARDRAYVASLLTVALHGKLEYFTDILRTLLSDLVAQYVAKNPKLMLRRTETVVEKLLTNWMSICLYTFVRDSVGEPLYMLFRG
IKHQVDKGPVDSVTGKAKYTLNDNRLLREDVEYRPLTLNALLAVGPGAGEAQGVPVKVLDCDTISQAKEKMLDQLYKGVPLTQRPDPRTL
DVEWRSGVAGHLILSDEDVTSEVQGLWRRLNTLQHYKVPDGATVALVPCLTKHVLRENQDYVPGERTPMLEDVDEGGIRPWHLVKPSDEP
EPPRPRRGSLRGGERERAKAIPEIYLTRLLSMKGTLQKFVDDLFQVILSTSRPVPLAVKYFFDLLDEQAQQHGISDQDTIHIWKTNSLLL
RFWVNALKNPQLIFDVRVSDNVDAILAVIAQTFIDSCTTSEHKVGRDSPVNKLLYAREIPRYKQMVERYYADIRQSSPASYQEMNSALAE

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Fusion Gene PPI Analysis for PLXNB1-PLXNB3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PLXNB1-PLXNB3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PLXNB1-PLXNB3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource