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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PLXNB2-MAST4 (FusionGDB2 ID:66562)

Fusion Gene Summary for PLXNB2-MAST4

check button Fusion gene summary
Fusion gene informationFusion gene name: PLXNB2-MAST4
Fusion gene ID: 66562
HgeneTgene
Gene symbol

PLXNB2

MAST4

Gene ID

23654

375449

Gene nameplexin B2microtubule associated serine/threonine kinase family member 4
SynonymsMM1|Nbla00445|PLEXB2|dJ402G11.3-
Cytomap

22q13.33

5q12.3

Type of geneprotein-codingprotein-coding
Descriptionplexin-B2microtubule-associated serine/threonine-protein kinase 4
Modification date2020031320200313
UniProtAcc.

O15021

Ensembl transtripts involved in fusion geneENST00000359337, ENST00000449103, 
ENST00000496720, 		ENST00000261569, 
ENST00000403666, ENST00000405643, 
ENST00000407621, ENST00000478569, 
ENST00000490016, ENST00000403625, 
ENST00000404260, ENST00000406039, 
ENST00000406374, 
Fusion gene scores* DoF score19 X 16 X 11=33447 X 8 X 5=280
# samples 228
** MAII scorelog2(22/3344*10)=-3.92599941855622
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/280*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PLXNB2 [Title/Abstract] AND MAST4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPLXNB2(50722031)-MAST4(66195779), # samples:3
Anticipated loss of major functional domain due to fusion event.PLXNB2-MAST4 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PLXNB2-MAST4 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
PLXNB2-MAST4 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePLXNB2

GO:0007156

homophilic cell adhesion via plasma membrane adhesion molecules

16122393

HgenePLXNB2

GO:0010976

positive regulation of neuron projection development

16122393


check buttonFusion gene breakpoints across PLXNB2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MAST4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRPTCGA-P4-A5EB-01APLXNB2chr22

50722031

-MAST4chr5

66195779

+
ChimerDB4KIRPTCGA-P4-A5EBPLXNB2chr22

50722030

-MAST4chr5

66195778

+
ChimerDB4KIRPTCGA-P4-A5EBPLXNB2chr22

50722031

-MAST4chr5

66195779

+


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Fusion Gene ORF analysis for PLXNB2-MAST4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000359337ENST00000261569PLXNB2chr22

50722031

-MAST4chr5

66195779

+
5CDS-intronENST00000359337ENST00000261569PLXNB2chr22

50722030

-MAST4chr5

66195778

+
5CDS-intronENST00000359337ENST00000403666PLXNB2chr22

50722031

-MAST4chr5

66195779

+
5CDS-intronENST00000359337ENST00000403666PLXNB2chr22

50722030

-MAST4chr5

66195778

+
5CDS-intronENST00000359337ENST00000405643PLXNB2chr22

50722031

-MAST4chr5

66195779

+
5CDS-intronENST00000359337ENST00000405643PLXNB2chr22

50722030

-MAST4chr5

66195778

+
5CDS-intronENST00000359337ENST00000407621PLXNB2chr22

50722031

-MAST4chr5

66195779

+
5CDS-intronENST00000359337ENST00000407621PLXNB2chr22

50722030

-MAST4chr5

66195778

+
5CDS-intronENST00000359337ENST00000478569PLXNB2chr22

50722031

-MAST4chr5

66195779

+
5CDS-intronENST00000359337ENST00000478569PLXNB2chr22

50722030

-MAST4chr5

66195778

+
5CDS-intronENST00000359337ENST00000490016PLXNB2chr22

50722031

-MAST4chr5

66195779

+
5CDS-intronENST00000359337ENST00000490016PLXNB2chr22

50722030

-MAST4chr5

66195778

+
5CDS-intronENST00000449103ENST00000261569PLXNB2chr22

50722031

-MAST4chr5

66195779

+
5CDS-intronENST00000449103ENST00000261569PLXNB2chr22

50722030

-MAST4chr5

66195778

+
5CDS-intronENST00000449103ENST00000403666PLXNB2chr22

50722031

-MAST4chr5

66195779

+
5CDS-intronENST00000449103ENST00000403666PLXNB2chr22

50722030

-MAST4chr5

66195778

+
5CDS-intronENST00000449103ENST00000405643PLXNB2chr22

50722031

-MAST4chr5

66195779

+
5CDS-intronENST00000449103ENST00000405643PLXNB2chr22

50722030

-MAST4chr5

66195778

+
5CDS-intronENST00000449103ENST00000407621PLXNB2chr22

50722031

-MAST4chr5

66195779

+
5CDS-intronENST00000449103ENST00000407621PLXNB2chr22

50722030

-MAST4chr5

66195778

+
5CDS-intronENST00000449103ENST00000478569PLXNB2chr22

50722031

-MAST4chr5

66195779

+
5CDS-intronENST00000449103ENST00000478569PLXNB2chr22

50722030

-MAST4chr5

66195778

+
5CDS-intronENST00000449103ENST00000490016PLXNB2chr22

50722031

-MAST4chr5

66195779

+
5CDS-intronENST00000449103ENST00000490016PLXNB2chr22

50722030

-MAST4chr5

66195778

+
5UTR-3CDSENST00000496720ENST00000403625PLXNB2chr22

50722031

-MAST4chr5

66195779

+
5UTR-3CDSENST00000496720ENST00000403625PLXNB2chr22

50722030

-MAST4chr5

66195778

+
5UTR-3CDSENST00000496720ENST00000404260PLXNB2chr22

50722031

-MAST4chr5

66195779

+
5UTR-3CDSENST00000496720ENST00000404260PLXNB2chr22

50722030

-MAST4chr5

66195778

+
5UTR-3CDSENST00000496720ENST00000406039PLXNB2chr22

50722031

-MAST4chr5

66195779

+
5UTR-3CDSENST00000496720ENST00000406039PLXNB2chr22

50722030

-MAST4chr5

66195778

+
5UTR-3CDSENST00000496720ENST00000406374PLXNB2chr22

50722031

-MAST4chr5

66195779

+
5UTR-3CDSENST00000496720ENST00000406374PLXNB2chr22

50722030

-MAST4chr5

66195778

+
5UTR-intronENST00000496720ENST00000261569PLXNB2chr22

50722031

-MAST4chr5

66195779

+
5UTR-intronENST00000496720ENST00000261569PLXNB2chr22

50722030

-MAST4chr5

66195778

+
5UTR-intronENST00000496720ENST00000403666PLXNB2chr22

50722031

-MAST4chr5

66195779

+
5UTR-intronENST00000496720ENST00000403666PLXNB2chr22

50722030

-MAST4chr5

66195778

+
5UTR-intronENST00000496720ENST00000405643PLXNB2chr22

50722031

-MAST4chr5

66195779

+
5UTR-intronENST00000496720ENST00000405643PLXNB2chr22

50722030

-MAST4chr5

66195778

+
5UTR-intronENST00000496720ENST00000407621PLXNB2chr22

50722031

-MAST4chr5

66195779

+
5UTR-intronENST00000496720ENST00000407621PLXNB2chr22

50722030

-MAST4chr5

66195778

+
5UTR-intronENST00000496720ENST00000478569PLXNB2chr22

50722031

-MAST4chr5

66195779

+
5UTR-intronENST00000496720ENST00000478569PLXNB2chr22

50722030

-MAST4chr5

66195778

+
5UTR-intronENST00000496720ENST00000490016PLXNB2chr22

50722031

-MAST4chr5

66195779

+
5UTR-intronENST00000496720ENST00000490016PLXNB2chr22

50722030

-MAST4chr5

66195778

+
Frame-shiftENST00000449103ENST00000403625PLXNB2chr22

50722031

-MAST4chr5

66195779

+
Frame-shiftENST00000449103ENST00000403625PLXNB2chr22

50722030

-MAST4chr5

66195778

+
Frame-shiftENST00000449103ENST00000404260PLXNB2chr22

50722031

-MAST4chr5

66195779

+
Frame-shiftENST00000449103ENST00000404260PLXNB2chr22

50722030

-MAST4chr5

66195778

+
Frame-shiftENST00000449103ENST00000406039PLXNB2chr22

50722031

-MAST4chr5

66195779

+
Frame-shiftENST00000449103ENST00000406039PLXNB2chr22

50722030

-MAST4chr5

66195778

+
Frame-shiftENST00000449103ENST00000406374PLXNB2chr22

50722031

-MAST4chr5

66195779

+
Frame-shiftENST00000449103ENST00000406374PLXNB2chr22

50722030

-MAST4chr5

66195778

+
In-frameENST00000359337ENST00000403625PLXNB2chr22

50722031

-MAST4chr5

66195779

+
In-frameENST00000359337ENST00000403625PLXNB2chr22

50722030

-MAST4chr5

66195778

+
In-frameENST00000359337ENST00000404260PLXNB2chr22

50722031

-MAST4chr5

66195779

+
In-frameENST00000359337ENST00000404260PLXNB2chr22

50722030

-MAST4chr5

66195778

+
In-frameENST00000359337ENST00000406039PLXNB2chr22

50722031

-MAST4chr5

66195779

+
In-frameENST00000359337ENST00000406039PLXNB2chr22

50722030

-MAST4chr5

66195778

+
In-frameENST00000359337ENST00000406374PLXNB2chr22

50722031

-MAST4chr5

66195779

+
In-frameENST00000359337ENST00000406374PLXNB2chr22

50722030

-MAST4chr5

66195778

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000359337PLXNB2chr2250722031-ENST00000404260MAST4chr566195779+124622679264099172425
ENST00000359337PLXNB2chr2250722031-ENST00000403625MAST4chr566195779+124532679264099082422
ENST00000359337PLXNB2chr2250722031-ENST00000406374MAST4chr566195779+28272679702688872
ENST00000359337PLXNB2chr2250722031-ENST00000406039MAST4chr566195779+27542679702688872
ENST00000359337PLXNB2chr2250722030-ENST00000404260MAST4chr566195778+124622679264099172425
ENST00000359337PLXNB2chr2250722030-ENST00000403625MAST4chr566195778+124532679264099082422
ENST00000359337PLXNB2chr2250722030-ENST00000406374MAST4chr566195778+28272679702688872
ENST00000359337PLXNB2chr2250722030-ENST00000406039MAST4chr566195778+27542679702688872

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000359337ENST00000404260PLXNB2chr2250722031-MAST4chr566195779+0.0301597940.9698402
ENST00000359337ENST00000403625PLXNB2chr2250722031-MAST4chr566195779+0.029899170.97010076
ENST00000359337ENST00000406374PLXNB2chr2250722031-MAST4chr566195779+0.005756670.9942433
ENST00000359337ENST00000406039PLXNB2chr2250722031-MAST4chr566195779+0.0061003510.9938996
ENST00000359337ENST00000404260PLXNB2chr2250722030-MAST4chr566195778+0.0301597940.9698402
ENST00000359337ENST00000403625PLXNB2chr2250722030-MAST4chr566195778+0.029899170.97010076
ENST00000359337ENST00000406374PLXNB2chr2250722030-MAST4chr566195778+0.005756670.9942433
ENST00000359337ENST00000406039PLXNB2chr2250722030-MAST4chr566195778+0.0061003510.9938996

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Fusion Genomic Features for PLXNB2-MAST4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PLXNB2chr2250722030-MAST4chr566195778+0.304674360.6953257
PLXNB2chr2250722030-MAST4chr566195778+0.304674360.6953257
PLXNB2chr2250722030-MAST4chr566195778+0.304674360.6953257
PLXNB2chr2250722030-MAST4chr566195778+0.304674360.6953257

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PLXNB2-MAST4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:50722031/chr5:66195779)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MAST4

O15021

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePLXNB2chr22:50722030chr5:66195778ENST00000359337-153720_4668561839.0DomainSema
HgenePLXNB2chr22:50722030chr5:66195778ENST00000449103-153720_4668561839.0DomainSema
HgenePLXNB2chr22:50722031chr5:66195779ENST00000359337-153720_4668561839.0DomainSema
HgenePLXNB2chr22:50722031chr5:66195779ENST00000449103-153720_4668561839.0DomainSema
TgeneMAST4chr22:50722030chr5:66195778ENST000002615690262125_220802430.0Compositional biasPro-rich
TgeneMAST4chr22:50722030chr5:66195778ENST0000026156902663_10802430.0Compositional biasPro-rich
TgeneMAST4chr22:50722030chr5:66195778ENST000004036660282125_2208132435.0Compositional biasPro-rich
TgeneMAST4chr22:50722030chr5:66195778ENST0000040366602863_108132435.0Compositional biasPro-rich
TgeneMAST4chr22:50722030chr5:66195778ENST00000406374262125_2208214251.0Compositional biasPro-rich
TgeneMAST4chr22:50722031chr5:66195779ENST000002615690262125_220802430.0Compositional biasPro-rich
TgeneMAST4chr22:50722031chr5:66195779ENST0000026156902663_10802430.0Compositional biasPro-rich
TgeneMAST4chr22:50722031chr5:66195779ENST000004036660282125_2208132435.0Compositional biasPro-rich
TgeneMAST4chr22:50722031chr5:66195779ENST0000040366602863_108132435.0Compositional biasPro-rich
TgeneMAST4chr22:50722031chr5:66195779ENST00000406374262125_2208214251.0Compositional biasPro-rich
TgeneMAST4chr22:50722030chr5:66195778ENST000002615690261141_122902430.0DomainPDZ
TgeneMAST4chr22:50722030chr5:66195778ENST00000261569026570_84302430.0DomainProtein kinase
TgeneMAST4chr22:50722030chr5:66195778ENST00000261569026844_91602430.0DomainAGC-kinase C-terminal
TgeneMAST4chr22:50722030chr5:66195778ENST000004036660281141_1229132435.0DomainPDZ
TgeneMAST4chr22:50722030chr5:66195778ENST00000403666028570_843132435.0DomainProtein kinase
TgeneMAST4chr22:50722030chr5:66195778ENST00000403666028844_916132435.0DomainAGC-kinase C-terminal
TgeneMAST4chr22:50722030chr5:66195778ENST00000406374261141_1229214251.0DomainPDZ
TgeneMAST4chr22:50722030chr5:66195778ENST0000040637426570_843214251.0DomainProtein kinase
TgeneMAST4chr22:50722030chr5:66195778ENST0000040637426844_916214251.0DomainAGC-kinase C-terminal
TgeneMAST4chr22:50722031chr5:66195779ENST000002615690261141_122902430.0DomainPDZ
TgeneMAST4chr22:50722031chr5:66195779ENST00000261569026570_84302430.0DomainProtein kinase
TgeneMAST4chr22:50722031chr5:66195779ENST00000261569026844_91602430.0DomainAGC-kinase C-terminal
TgeneMAST4chr22:50722031chr5:66195779ENST000004036660281141_1229132435.0DomainPDZ
TgeneMAST4chr22:50722031chr5:66195779ENST00000403666028570_843132435.0DomainProtein kinase
TgeneMAST4chr22:50722031chr5:66195779ENST00000403666028844_916132435.0DomainAGC-kinase C-terminal
TgeneMAST4chr22:50722031chr5:66195779ENST00000406374261141_1229214251.0DomainPDZ
TgeneMAST4chr22:50722031chr5:66195779ENST0000040637426570_843214251.0DomainProtein kinase
TgeneMAST4chr22:50722031chr5:66195779ENST0000040637426844_916214251.0DomainAGC-kinase C-terminal
TgeneMAST4chr22:50722030chr5:66195778ENST00000261569026576_58402430.0Nucleotide bindingATP
TgeneMAST4chr22:50722030chr5:66195778ENST00000403666028576_584132435.0Nucleotide bindingATP
TgeneMAST4chr22:50722030chr5:66195778ENST0000040637426576_584214251.0Nucleotide bindingATP
TgeneMAST4chr22:50722031chr5:66195779ENST00000261569026576_58402430.0Nucleotide bindingATP
TgeneMAST4chr22:50722031chr5:66195779ENST00000403666028576_584132435.0Nucleotide bindingATP
TgeneMAST4chr22:50722031chr5:66195779ENST0000040637426576_584214251.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePLXNB2chr22:50722030chr5:66195778ENST00000359337-1537803_8938561839.0DomainNote=IPT/TIG 1
HgenePLXNB2chr22:50722030chr5:66195778ENST00000359337-1537895_9808561839.0DomainNote=IPT/TIG 2
HgenePLXNB2chr22:50722030chr5:66195778ENST00000359337-1537983_10928561839.0DomainNote=IPT/TIG 3
HgenePLXNB2chr22:50722030chr5:66195778ENST00000449103-1537803_8938561839.0DomainNote=IPT/TIG 1
HgenePLXNB2chr22:50722030chr5:66195778ENST00000449103-1537895_9808561839.0DomainNote=IPT/TIG 2
HgenePLXNB2chr22:50722030chr5:66195778ENST00000449103-1537983_10928561839.0DomainNote=IPT/TIG 3
HgenePLXNB2chr22:50722031chr5:66195779ENST00000359337-1537803_8938561839.0DomainNote=IPT/TIG 1
HgenePLXNB2chr22:50722031chr5:66195779ENST00000359337-1537895_9808561839.0DomainNote=IPT/TIG 2
HgenePLXNB2chr22:50722031chr5:66195779ENST00000359337-1537983_10928561839.0DomainNote=IPT/TIG 3
HgenePLXNB2chr22:50722031chr5:66195779ENST00000449103-1537803_8938561839.0DomainNote=IPT/TIG 1
HgenePLXNB2chr22:50722031chr5:66195779ENST00000449103-1537895_9808561839.0DomainNote=IPT/TIG 2
HgenePLXNB2chr22:50722031chr5:66195779ENST00000449103-1537983_10928561839.0DomainNote=IPT/TIG 3
HgenePLXNB2chr22:50722030chr5:66195778ENST00000359337-15371219_18388561839.0Topological domainCytoplasmic
HgenePLXNB2chr22:50722030chr5:66195778ENST00000359337-153720_11978561839.0Topological domainExtracellular
HgenePLXNB2chr22:50722030chr5:66195778ENST00000449103-15371219_18388561839.0Topological domainCytoplasmic
HgenePLXNB2chr22:50722030chr5:66195778ENST00000449103-153720_11978561839.0Topological domainExtracellular
HgenePLXNB2chr22:50722031chr5:66195779ENST00000359337-15371219_18388561839.0Topological domainCytoplasmic
HgenePLXNB2chr22:50722031chr5:66195779ENST00000359337-153720_11978561839.0Topological domainExtracellular
HgenePLXNB2chr22:50722031chr5:66195779ENST00000449103-15371219_18388561839.0Topological domainCytoplasmic
HgenePLXNB2chr22:50722031chr5:66195779ENST00000449103-153720_11978561839.0Topological domainExtracellular
HgenePLXNB2chr22:50722030chr5:66195778ENST00000359337-15371198_12188561839.0TransmembraneHelical
HgenePLXNB2chr22:50722030chr5:66195778ENST00000449103-15371198_12188561839.0TransmembraneHelical
HgenePLXNB2chr22:50722031chr5:66195779ENST00000359337-15371198_12188561839.0TransmembraneHelical
HgenePLXNB2chr22:50722031chr5:66195779ENST00000449103-15371198_12188561839.0TransmembraneHelical
TgeneMAST4chr22:50722030chr5:66195778ENST000004063742663_108214251.0Compositional biasPro-rich
TgeneMAST4chr22:50722031chr5:66195779ENST000004063742663_108214251.0Compositional biasPro-rich


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Fusion Gene Sequence for PLXNB2-MAST4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>66562_66562_1_PLXNB2-MAST4_PLXNB2_chr22_50722030_ENST00000359337_MAST4_chr5_66195778_ENST00000403625_length(transcript)=12453nt_BP=2679nt
CCCGGGCGCCATCGAGCCTTGGCGGCGGACGTGCAGAGAATCTCGATGCTGGCCTGGAGCAGAAACTGAGCTGGACCACTGGAGCCTCGG
TGAGGGGGTGCGGGGGGCAATGGCACTGCAGCTCTGGGCCCTGACCCTGCTGGGCCTGCTGGGCGCAGGTGCCAGCCTGAGGCCCCGCAA
GCTGGACTTCTTCCGCAGCGAGAAAGAGCTGAACCACCTGGCTGTGGATGAGGCCTCAGGCGTGGTGTACCTGGGGGCGGTGAATGCCCT
CTACCAGCTGGATGCGAAGCTGCAGCTGGAGCAGCAGGTGGCCACGGGCCCGGCCCTGGACAACAAGAAGTGCACGCCGCCCATCGAGGC
CAGCCAGTGCCATGAGGCTGAGATGACTGACAATGTCAACCAGCTGCTGCTGCTCGACCCTCCCAGGAAGCGCCTGGTGGAGTGCGGCAG
CCTCTTCAAGGGCATCTGCGCTCTGCGCGCCCTGAGCAACATCTCCCTCCGCCTGTTCTACGAGGACGGCAGCGGGGAGAAGTCTTTCGT
GGCCAGCAATGATGAGGGCGTGGCCACAGTGGGGCTGGTGAGCTCCACGGGTCCTGGTGGTGACCGCGTGCTGTTTGTGGGCAAAGGCAA
TGGGCCACACGACAACGGCATCATCGTGAGCACTCGGCTGTTGGACCGGACTGACAGCAGGGAGGCCTTTGAAGCCTACACGGACCACGC
CACCTACAAGGCCGGCTACCTGTCCACCAACACACAGCAGTTCGTGGCGGCCTTCGAGGACGGCCCCTACGTCTTCTTTGTCTTCAACCA
GCAGGACAAGCACCCGGCCCGGAACCGCACGCTGCTGGCACGCATGTGCAGAGAAGACCCCAACTACTACTCCTACCTGGAGATGGACCT
GCAGTGCCGGGACCCCGACATCCACGCCGCTGCCTTTGGCACCTGCCTGGCCGCCTCCGTGGCTGCGCCTGGCTCTGGCAGGGTGCTATA
TGCTGTCTTCAGCAGAGACAGCCGGAGCAGTGGGGGGCCCGGTGCGGGCCTCTGCCTGTTCCCGCTGGACAAGGTGCACGCCAAGATGGA
GGCCAACCGCAACGCCTGTTACACAGGCACCCGGGAGGCCCGTGACATCTTCTACAAGCCCTTCCACGGCGATATCCAGTGCGGCGGCCA
CGCGCCGGGCTCCAGCAAGAGCTTCCCATGTGGCTCGGAGCACCTGCCCTACCCGCTGGGCAGCCGCGACGGGCTCAGAGGCACAGCCGT
GCTGCAGCGTGGAGGCCTGAACCTCACGGCCGTGACGGTCGCCGCCGAGAACAACCACACTGTTGCTTTTCTGGGCACCTCTGATGGCCG
GATCCTCAAGGTGTACCTCACCCCAGATGGCACCTCCTCAGAGTACGACTCTATCCTTGTGGAGATAAACAAGAGAGTCAAGCGCGACCT
GGTACTGTCTGGAGACCTGGGCAGCCTGTACGCCATGACCCAGGACAAGGTGTTCCGGCTGCCGGTGCAGGAGTGCCTGAGCTACCCGAC
CTGCACCCAGTGCCGCGACTCCCAGGACCCCTACTGCGGCTGGTGCGTCGTCGAGGGACGATGCACCCGGAAGGCCGAGTGTCCGCGGGC
CGAGGAGGCCAGCCACTGGCTGTGGAGCCGAAGCAAGTCCTGCGTGGCCGTCACCAGCGCCCAGCCACAGAACATGAGCCGGCGGGCCCA
GGGGGAGGTGCAGCTGACCGTCAGCCCCCTCCCTGCCCTGAGCGAGGAGGACGAGTTGCTGTGCCTTTTTGGGGAGTCGCCGCCACACCC
CGCCCGCGTGGAGGGCGAGGCCGTCATCTGCAACTCCCCAAGCAGCATCCCCGTCACACCGCCAGGCCAGGACCACGTGGCCGTGACCAT
CCAGCTCCTCCTTAGACGAGGCAACATCTTCCTCACGTCCTACCAGTACCCCTTCTACGACTGCCGCCAGGCCATGAGCCTGGAGGAGAA
CCTGCCGTGCATCTCCTGCGTGAGCAACCGCTGGACCTGCCAGTGGGACCTGCGCTACCACGAGTGCCGGGAGGCTTCGCCCAACCCTGA
GGACGGCATCGTCCGTGCCCACATGGAGGACAGCTGTCCCCAGTTCCTGGGACCCAGCCCCCTGGTGATCCCCATGAACCACGAGACAGA
TGTGAACTTCCAGGGCAAGAACCTGGACACCGTGAAGGGTTCCTCCCTGCACGTGGGCAGTGACTTGCTCAAGTTCATGGAGCCGGTGAC
CATGCAGGAATCTGGGACCTTCGCCTTTCGGACCCCAAAGCTGTCCCACGATGCCAACGAGACGCTGCCCCTGCACCTCTACGTCAAGTC
TTACGGCAAGAATATCGACAGCAAGCTCCATGTGACCCTCTACAACTGCTCCTTTGGCCGCAGCGACTGCAGCCTGTGCCGGGCCGCTAA
CCCCGACTACAGGTGTGCGTGGTGCGGGGGCCAGAGCAGGTGCGTGTATGAGGCCCTGTGCAACACCACCTCCGAGTGCCCGCCGCCCGT
CATCACCAGGATCCAGCCTGAGACGGGCCCCCTGGGTGGGGGCATCCGCATCACCATCCTGGGGTCCAATTTGGGCGTCCAAGCAGGGGA
CATCCAGAGGATCTCTGTGGCCGGCCGGAACTGCTCCTTTCAGCCGGAACGTTACTCCGTGTCCACCCGAAGGAGCTGAGTCTCCCCAGA
AGAGGAAGTTTTTGCCGAACAAGCAACCGGAAAAGCTTAATAGGCAATGGGCAGTCACCAGCATTGCCTCGACCACACTCACCTCTCTCT
GCTCATGCAGGAAATAGCCCTCAAGATAGTCCAAGAAATTTCTCCCCCAGTGCCTCAGCCCATTTTTCATTTGCACGGAGGACTGATGGA
CGCCGCTGGTCGTTGGCTTCTCTCCCTTCCTCTGGCTATGGGACAAACACACCCAGCTCTACGGTCTCTTCATCCTGTTCCTCCCAGGAG
AAGTTGCATCAGTTACCATACCAACCAACACCAGACGAGTTACACTTCTTATCAAAACATTTCTGTACCACCGAAAGCATCGCCACTGAG
AACAGATGCAGGAACACGCCGATGCGCCCCCGTTCCCGAAGTCTGAGCCCTGGACGTTCTCCCGCCTGCTGTGACCATGAAATAATTATG
ATGAACCATGTCTACAAAGAAAGGTTCCCAAAGGCTACAGCTCAGATGGAAGAACGTCTAAAGGAAATTATCACCAGCTACTCTCCTGAC
AACGTTCTACCCTTAGCAGATGGAGTGCTTAGTTTCACTCACCACCAGATTATTGAACTGGCTCGAGATTGCTTGGATAAATCCCACCAG
GGCCTCATCACCTCACGATACTTCCTTGAATTACAGCACAAATTAGATAAGTTGCTACAGGAGGCTCATGATCGTTCAGAAAGTGGAGAA
TTGGCATTTATTAAACAACTAGTTCGAAAGATCCTAATTGTTATTGCCCGCCCTGCTCGGTTATTAGAGTGCCTGGAATTTGATCCGGAA
GAATTTTACTACCTATTGGAAGCAGCAGAAGGCCATGCCAAAGAAGGACAGGGTATTAAAACCGACATTCCCAGGTACATCATTAGCCAA
CTGGGACTCAATAAGGATCCCTTGGAAGAAATGGCTCATTTGGGAAACTACGATAGTGGGACAGCAGAAACACCAGAAACAGATGAATCA
GTGAGTAGCTCTAATGCCTCCCTGAAACTTCGAAGGAAACCTCGGGAAAGTGATTTTGAAACGATTAAATTGATTAGCAATGGAGCCTAT
GGGGCAGTCTACTTTGTTCGGCATAAAGAATCCCGGCAGAGGTTTGCCATGAAGAAGATTAATAAACAGAACCTCATCCTTCGAAACCAG
ATCCAGCAGGCCTTTGTGGAGCGGGATATCCTGACTTTTGCAGAAAACCCCTTTGTTGTCAGCATGTATTGCTCCTTTGAAACAAGGCGC
CACTTGTGCATGGTCATGGAATATGTGGAAGGGGGAGACTGTGCTACTTTAATGAAAAACATGGGTCCTCTCCCTGTTGATATGGCCAGA
ATGTACTTTGCTGAGACGGTCTTGGCCTTGGAATATTTACATAATTATGGAATTGTACACAGGGATTTGAAACCAGACAACTTGTTGGTT
ACCTCCATGGGGCACATAAAGCTGACAGATTTTGGATTATCTAAGGTGGGACTAATGAGCATGACTACCAACCTTTACGAGGGTCATATT
GAGAAGGATGCTAGAGAGTTCCTGGATAAACAGGTCTGTGGCACACCTGAATACATTGCACCAGAAGTGATTCTGAGGCAGGGTTATGGA
AAGCCGGTGGACTGGTGGGCCATGGGGATTATCCTCTATGAATTTCTGGTTGGATGCGTGCCATTCTTTGGGGATACTCCAGAGGAGCTA
TTTGGACAAGTCATCAGTGATGAGATCAACTGGCCTGAGAAGGATGAGGCACCCCCACCTGATGCCCAGGATCTGATTACCTTACTCCTC
AGGCAGAATCCCCTGGAGAGGCTGGGAACAGGTGGTGCATATGAAGTCAAACAGCATCGATTCTTCCGTTCTTTAGACTGGAACAGTTTG
CTGAGACAGAAGGCAGAATTTATTCCCCAACTGGAATCTGAGGATGACACAAGTTATTTTGATACTCGGTCTGAGAAGTATCATCATATG
GAAACGGAGGAAGAAGATGACACAAATGATGAAGACTTTAATGTGGAAATAAGGCAGTTTTCTTCATGTTCACACAGGTTTTCAAAAGTT
TTCAGCAGTATAGATCGAATCACTCAGAATTCAGCAGAAGAGAAGGAAGACTCTGTGGACAAAACCAAAAGCACCACCTTGCCATCCACA
GAAACACTGAGCTGGAGTTCAGAATATTCTGAAATGCAACAGCTATCAACATCCAACTCTTCAGATACTGAAAGCAACAGACATAAACTC
AGTTCTGGCCTACTTCCCAAACTGGCTATTTCAACAGAGGGAGAGCAAGATGAAGCTGCCTCCTGCCCTGGAGACCCCCATGAGGAGCCA
GGAAAGCCAGCCCTTCCTCCTGAAGAGTGTGCCCAGGAGGAGCCTGAGGTCACCACCCCAGCCAGCACCATCAGCAGCTCCACCCTGTCA
GTTGGCAGTTTTTCAGAGCACTTGGATCAGATAAATGGACGAAGCGAGTGTGTGGACAGTACAGATAATTCCTCAAAGCCATCCAGTGAA
CCCGCTTCTCACATGGCTCGGCAGCGATTAGAAAGCACAGAAAAAAAGAAAATCTCGGGGAAAGTCACAAAGTCCCTCTCTGCCAGTGCT
CTTTCCCTCATGATCCCAGGAGATATGTTTGCTGTTTCCCCTCTGGGAAGTCCAATGTCTCCCCATTCCCTGTCCTCGGACCCTTCTTCT
TCACGAGATTCCTCTCCCAGCCGAGATTCCTCAGCAGCTTCTGCCAGTCCACATCAGCCGATTGTGATCCACAGTTCGGGGAAGAACTAC
GGCTTTACCATCCGAGCCATCCGGGTGTATGTGGGAGACAGTGACATCTATACAGTGCACCATATCGTCTGGAATGTAGAAGAAGGAAGT
CCGGCATGCCAGGCAGGACTGAAGGCTGGAGATCTTATCACTCACATCAATGGAGAACCAGTGCATGGACTTGTCCACACAGAAGTTATA
GAACTCCTACTGAAGAGTGGGAATAAGGTGTCAATCACTACTACCCCATTTGAAAACACATCAATCAAAACTGGACCAGCCAGGAGAAAC
AGCTATAAGAGCCGGATGGTGAGGCGGAGCAAGAAATCCAAGAAGAAAGAAAGTCTCGAAAGGAGGAGATCTCTTTTCAAAAAGCTAGCC
AAGCAGCCTTCTCCTTTACTCCACACCAGCCGAAGTTTCTCCTGCTTGAACAGATCCCTGTCATCGGGTGAGAGCCTCCCAGGTTCCCCC
ACTCATAGCTTGTCTCCCCGGTCTCCAACACCAAGCTACCGCTCCACCCCTGACTTCCCATCTGGTACTAATTCCTCCCAGAGCAGCTCC
CCTAGTTCTAGTGCCCCCAATTCCCCAGCAGGGTCCGGGCACATCCGGCCCAGCACTCTCCACGGTCTTGCACCCAAACTCGGCGGGCAG
CGGTACCGGTCCGGAAGGCGAAAGTCCGCCGGCAACATCCCACTGTCCCCGCTGGCCCGGACGCCCTCTCCAACCCCGCAACCCACCTCC
CCGCAGCGGTCACCATCCCCTCTTCTGGGACACTCACTGGGCAATTCCAAGATCGCGCAAGCCTTTCCCAGCAAGATGCACTCCCCGCCC
ACCATCGTCAGACACATCGTGAGGCCCAAGAGTGCGGAGCCCCCCAGGTCCCCGCTGCTCAAGCGCGTGCAGTCCGAGGAGAAGCTGTCG
CCCTCTTACGGCAGTGACAAGAAGCACCTGTGCTCCCGCAAGCACAGCCTGGAGGTGACCCAAGAGGAGGTGCAGCGGGAGCAGTCCCAG
CGGGAGGCGCCGCTGCAGAGCCTGGATGAGAACGTGTGCGACGTGCCGCCGCTCAGCCGCGCCCGGCCAGTGGAGCAAGGCTGCCTGAAA
CGCCCAGTCTCCCGGAAGGTGGGCCGCCAGGAGTCTGTGGACGACCTGGACCGCGACAAGCTGAAGGCCAAGGTGGTGGTGAAGAAAGCA
GACGGCTTCCCAGAGAAACAGGAATCCCACCAGAAATCCCATGGACCCGGGAGTGATTTGGAAAACTTTGCTCTGTTTAAGCTGGAAGAG
AGAGAGAAGAAAGTCTATCCGAAGGCTGTGGAAAGGTCAAGTACTTTTGAAAACAAAGCGTCTATGCAGGAGGCGCCACCGCTGGGCAGC
CTGCTGAAGGATGCTCTTCACAAGCAGGCCAGCGTGCGCGCCAGCGAGGGTGCGATGTCGGATGGCCGGGTGCCTGCGGAGCACCGCCAG
GGTGGCGGGGACTTCAGACGGGCCCCCGCTCCTGGCACCCTCCAGGATGGTCTCTGCCACTCCCTCGACAGGGGCATCTCTGGGAAGGGG
GAAGGCACGGAGAAGTCCTCCCAGGCCAAGGAGCTTCTCCGATGTGAAAAGTTAGACAGCAAGCTGGCCAACATCGATTACCTCCGAAAG
AAAATGTCACTTGAGGACAAAGAGGACAACCTCTGCCCTGTGCTGAAGCCCAAGATGACAGCTGGCTCCCACGAATGCCTGCCAGGGAAC
CCAGTCCGACCCACGGGTGGGCAGCAGGAGCCCCCGCCGGCTTCTGAGAGCCGAGCTTTTGTCAGCAGCACCCATGCAGCTCAGATGAGT
GCCGTCTCTTTTGTTCCCCTCAAGGCCTTAACAGGCCGGGTGGACAGTGGAACGGAGAAGCCTGGCTTGGTTGCTCCTGAGTCCCCTGTT
AGGAAGAGCCCCTCCGAGTATAAGCTGGAAGGTAGGTCTGTCTCATGCCTGAAGCCGATCGAGGGCACTCTGGACATTGCTCTCCTGTCC
GGACCTCAGGCCTCCAAGACAGAACTGCCTTCCCCAGAGTCTGCACAGAGCCCCAGCCCAAGTGGTGACGTGAGGGCCTCTGTGCCACCA
GTTCTCCCCAGCAGCAGTGGGAAAAAGAACGATACCACCAGTGCAAGAGAGCTTTCTCCTTCCAGCTTAAAGATGAATAAATCCTACCTG
CTGGAGCCTTGGTTCCTGCCCCCCAGCCGAGGTCTCCAGAATTCACCAGCAGTTTCCCTGCCTGACCCAGAGTTCAAGAGGGACAGGAAA
GGTCCCCATCCTACTGCCAGGAGCCCTGGAACAGTCATGGAAAGCAATCCCCAACAGAGAGAGGGCAGCTCCCCTAAACACCAAGACCAC
ACCACTGACCCCAAGCTTCTGACCTGCCTGGGGCAGAACCTCCACAGCCCTGACCTGGCCAGGCCACGCTGCCCGCTCCCACCTGAAGCT
TCCCCCTCAAGGGAGAAGCCAGGCCTGAGGGAATCGTCTGAAAGAGGCCCTCCCACAGCCAGAAGCGAGCGCTCTGCTGCGAGGGCTGAC
ACATGCAGAGAGCCCTCCATGGAACTGTGCTTTCCAGAAACTGCGAAAACCAGTGACAACTCCAAAAATCTCCTCTCTGTGGGAAGGACC
CACCCAGATTTCTATACACAGACCCAGGCCATGGAGAAAGCATGGGCGCCGGGTGGGAAAACGAACCACAAAGATGGCCCAGGTGAGGCG
AGGCCCCCGCCCAGAGACAACTCCTCTCTGCACTCAGCTGGAATTCCCTGTGAGAAGGAGCTGGGCAAGGTGAGGCGTGGCGTGGAACCC
AAGCCCGAAGCGCTTCTTGCCAGGCGGTCTCTGCAGCCACCTGGAATTGAGAGTGAGAAGAGTGAAAAGCTCTCCAGTTTCCCATCTTTG
CAGAAAGATGGTGCCAAGGAACCTGAAAGGAAGGAGCAGCCTCTACAAAGGCATCCCAGCAGCATCCCTCCGCCCCCTCTGACGGCCAAA
GACCTGTCCAGCCCGGCTGCCAGGCAGCATTGCAGTTCCCCAAGCCACGCTTCTGGCAGAGAGCCGGGGGCCAAGCCCAGCACTGCAGAG
CCCAGCTCGAGCCCCCAGGACCCTCCCAAGCCTGTTGCTGCGCACAGTGAAAGCAGCAGCCACAAGCCCCGGCCTGGCCCTGACCCGGGC
CCTCCAAAGACTAAGCACCCCGACCGGTCCCTCTCCTCTCAGAAACCAAGTGTCGGGGCCACAAAGGGCAAAGAGCCTGCCACTCAGTCC
CTCGGTGGCTCTAGCAGAGAGGGGAAGGGCCACAGTAAGAGTGGGCCGGATGTGTTTCCTGCTACCCCAGGCTCCCAGAACAAAGCCAGC
GATGGGATTGGCCAGGGAGAAGGTGGGCCCTCTGTCCCACTGCACACTGACAGGGCTCCTCTAGACGCCAAGCCACAACCCACCAGTGGT
GGGCGGCCCCTGGAGGTGCTGGAGAAGCCTGTGCATTTGCCAAGGCCGGGACACCCAGGGCCTAGTGAGCCAGCGGACCAGAAACTGTCC
GCTGTTGGTGAAAAGCAAACCCTGTCTCCAAAGCACCCCAAACCATCCACTGTGAAAGATTGCCCCACCCTGTGCAAACAGACAGACAAC
AGACAGACAGACAAAAGCCCGAGTCAGCCGGCCGCCAACACCGACAGAAGGGCGGAAGGGAAGAAATGCACTGAAGCACTTTATGCTCCA
GCAGAGGGCGACAAGCTCGAGGCCGGCCTTTCCTTTGTGCATAGCGAGAACCGGTTGAAAGGCGCGGAGCGGCCAGCCGCGGGGGTGGGG
AAGGGCTTCCCTGAGGCCAGAGGGAAAGGGCCCGGTCCCCAGAAGCCACCGACGGAGGCAGACAAGCCCAATGGCATGAAACGGTCCCCC
TCAGCCACTGGGCAGAGTTCTTTCCGATCCACGGCCCTCCCGGAAAAGTCTCTGAGCTGCTCCTCCAGCTTCCCTGAAACCAGGGCCGGA
GTTAGAGAGGCCTCTGCAGCCAGCAGCGACACCTCTTCTGCCAAGGCCGCCGGGGGCATGCTGGAGCTTCCAGCCCCCAGCAACAGGGAC
CATAGGAAGGCTCAGCCTGCCGGGGAGGGCCGAACCCACATGACAAAGAGTGACTCCCTGCCCTCCTTCCGGGTCTCCACCCTGCCTCTG
GAGTCACACCACCCCGACCCAAACACCATGGGCGGGGCCAGCCACCGGGACAGGGCTCTCTCGGTGACTGCCACCGTAGGGGAAACCAAA
GGGAAGGACCCTGCCCCAGCCCAGCCTCCCCCAGCTAGGAAACAGAACGTGGGCAGAGACGTGACCAAGCCATCCCCAGCCCCAAACACT
GACCGCCCCATCTCTCTTTCTAATGAGAAGGACTTTGTGGTACGGCAGAGGCGGGGGAAAGAGAGTTTGCGTAGCAGCCCTCACAAAAAG
GCCTTGTAACGGGGAGGGCCCAGGGGCAGGACTGTGGAGACCCGTCCTGAACGGGCGACTGTGTCTTGACTACCTTTCAAAACCAGCACT
GTGTGGGAATGTCCGCCAGGCAGAGCTCGGAGCCTCATTGAGACAGGGGAGAGAGAAAGACAAAGAGGGGACCTTCTTCCAGATGCCTTC
CCAGTTGTAACCGGTAAAACTGTTACCAGATAGTGTTTGTACAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTACCTTTACAGTTGAGGG
TTGTTGAGGAAAATGATTTTCTTTGTAAATATATAGCATCGTGTTTGGTTTGGGATGTAGAGTCTATACCTGGCTGCTGATTGCGTCGTT
TACTACAGCTTTTTTTAAATAAGATTTTTGCTTTACCATTTATCATAATGTAGTAATGAAGCAAAATGGTCAAAACTGGGTGTGTGTGAA
CAGAGATACACCCATATTCGTGTATATACACATCCACCTACATGTTTTGGTCTGTGGTTTAAGAGACTATTTCAAGGTTCCATTTTTATA
AGCTAAAACATTCTAAGTTAAGATGGAAGAAAGCCCTAAACACAGTAGATTCTGAGTTTTTATGTGTATTTTAACCAGAGTTTCTGATAG
TACTGTATCTGGCTACCTATATTTCCAGATCTAAAGCAAGAACTACTCTAAGTACTGCATTTGGAATCCTCCTCCATTAGGAATGGCCAG
GACAAGTGGAGCTAGCCATTTTCATTACACGGCCATCCCAATGGACACTGGATCCCTGGTCCAACTGTCTAAAAGGCCAGTTGTTCCTTT
CTGTGGATGTGGATGTCTGGCCTTCACCTGAGGTAGAGCGGGGACTATAAACACACATCAACTTTCTTTCTGTTTGCTTTCTTTTCCTTC
TTTTCAAACTCTTAAACTCAGGCCTTTATGCTGTGAGTGACTAGTCCAAGAAGCACACATTTTGTAGTAGTCCTGCACCAGCCCTGCTCT
TGAATAAAAAGGAAAATTACTGGCTGCACCCAAATCTTCTAGTACTTGAGTAATAAGCATCAGGCATTGGAAGAGGTTTTAAATTTGCTT
TTTTGAGGAAAAGAACTGGGGGTGGATTTTGGCATCGTAGCATATCGATTAAAGAATAATCAGGACATCAGATACATTTTAATACATAGC
TGGGGCCTTATGTTGTAGATGAAGCTTGCTGTTTTTAGCAAGTTCCTGGGTTTCACATTCATTTCTGCTGCATCTAGTAGCTCCACACAT
TTCATAACCTGATCTCTTTATTTGTATGCAAAAAATACTGTCTTAATACAGAGCAGCATTTTTGTAACAAAGAGACTCGCTGGAGCTATT
TGGTGCTTGAATGTGACCATCCTTTTTACTTTTGCTAAGCCTTATTTAAATTTTGTATACCGTGGAATATGTAGAATTTGTCAAATCATT
TTAGTGCTGAAGGTTTTTGATTTCTTGTTTTTGTTTCTGTTGTTGCAGTTTCTTTGGTGGCTTGTTTTGTATTGTAAGATGGCACTTGCT
GATATAAATACTAAGGCACTAAGAGAAAATACAGATAAGTATTTATAAGTTGCTTGGGAACCATAGCAGAATTTTTTGTTTGGTTTTGTA
AGAGAAAAAAAATTACCAATAAATAACTGATCTAGCACCCAAACTCTCTTGGGGGATGTCTTAGTATCTTCACGCTATAAAATTGTTCAT
CTAAGCACAGCATCATCTTATGGCCTTATGGATTGTAAATCTTCTAGTGAGGCTATAAACTCCACTCTGAAAACAAAGGCATAACTTAAC
CGACTGCTCAGTTGTCCTTCGTTGTAAAATGAATTGGCTTTGGGAAAAAGGAAAAAAACAAACAAAAAAAGAAAAAGAAAAAAGCCTCCT
CCTTGCCCCTAATTTTTTTTTCCCATATGGTTTTAGCCATTCCCCATCACTATATTGTGAAGCTGTAAAAATATATATATATACTTTACA
AGAGTTTACTAATGGATTTCAAAACTGGTCTCAACGTTTATAATACATATCTGTGTTTGGCAGTTGTCATAACCCAATCCTACATTCAGC
CATCGGGACAAGTCTGTCGGGGAGGTAGTTCATGGTTTACAAGCCTTTGCTTTTTAACTGTCCAATTTCCTTTAAAGCACAACTAGCTAT
TTGTTTACAAATGATATTTTTATGTATATTTTGTATAGTGTATCATCATTTTTGCCAAATATGTTTTTCATTATAAATGAGTAAAGAGTA
CTTAAGGTTGCATTCATGTATTACATGTTTGTTGTTGTAAACCTCTCCAATCAGCTGGTAGAAATTCTCCTCATTGTGTTCTATTTGGTC
AGTCTCTGTGTGATTGTAGGATGTGCTCCTTGGTAGTACTCCCAGCTGTAGATTTACCAGCTTAAAAGTTTGTTAGGATCTGTGCAATAA
AGTGTTTGCAGTCTTATTTTCTCTAAGAAATTCCTTATGGACGTCATAATTGTTGTATATTGAACAAAATATTTATACTTATGCAGTTGC

>66562_66562_1_PLXNB2-MAST4_PLXNB2_chr22_50722030_ENST00000359337_MAST4_chr5_66195778_ENST00000403625_length(amino acids)=2422AA_BP=13
MLLSAGTLLRVHPKELSLPRRGSFCRTSNRKSLIGNGQSPALPRPHSPLSAHAGNSPQDSPRNFSPSASAHFSFARRTDGRRWSLASLPS
SGYGTNTPSSTVSSSCSSQEKLHQLPYQPTPDELHFLSKHFCTTESIATENRCRNTPMRPRSRSLSPGRSPACCDHEIIMMNHVYKERFP
KATAQMEERLKEIITSYSPDNVLPLADGVLSFTHHQIIELARDCLDKSHQGLITSRYFLELQHKLDKLLQEAHDRSESGELAFIKQLVRK
ILIVIARPARLLECLEFDPEEFYYLLEAAEGHAKEGQGIKTDIPRYIISQLGLNKDPLEEMAHLGNYDSGTAETPETDESVSSSNASLKL
RRKPRESDFETIKLISNGAYGAVYFVRHKESRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVSMYCSFETRRHLCMVMEYVE
GGDCATLMKNMGPLPVDMARMYFAETVLALEYLHNYGIVHRDLKPDNLLVTSMGHIKLTDFGLSKVGLMSMTTNLYEGHIEKDAREFLDK
QVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEINWPEKDEAPPPDAQDLITLLLRQNPLERLGT
GGAYEVKQHRFFRSLDWNSLLRQKAEFIPQLESEDDTSYFDTRSEKYHHMETEEEDDTNDEDFNVEIRQFSSCSHRFSKVFSSIDRITQN
SAEEKEDSVDKTKSTTLPSTETLSWSSEYSEMQQLSTSNSSDTESNRHKLSSGLLPKLAISTEGEQDEAASCPGDPHEEPGKPALPPEEC
AQEEPEVTTPASTISSSTLSVGSFSEHLDQINGRSECVDSTDNSSKPSSEPASHMARQRLESTEKKKISGKVTKSLSASALSLMIPGDMF
AVSPLGSPMSPHSLSSDPSSSRDSSPSRDSSAASASPHQPIVIHSSGKNYGFTIRAIRVYVGDSDIYTVHHIVWNVEEGSPACQAGLKAG
DLITHINGEPVHGLVHTEVIELLLKSGNKVSITTTPFENTSIKTGPARRNSYKSRMVRRSKKSKKKESLERRRSLFKKLAKQPSPLLHTS
RSFSCLNRSLSSGESLPGSPTHSLSPRSPTPSYRSTPDFPSGTNSSQSSSPSSSAPNSPAGSGHIRPSTLHGLAPKLGGQRYRSGRRKSA
GNIPLSPLARTPSPTPQPTSPQRSPSPLLGHSLGNSKIAQAFPSKMHSPPTIVRHIVRPKSAEPPRSPLLKRVQSEEKLSPSYGSDKKHL
CSRKHSLEVTQEEVQREQSQREAPLQSLDENVCDVPPLSRARPVEQGCLKRPVSRKVGRQESVDDLDRDKLKAKVVVKKADGFPEKQESH
QKSHGPGSDLENFALFKLEEREKKVYPKAVERSSTFENKASMQEAPPLGSLLKDALHKQASVRASEGAMSDGRVPAEHRQGGGDFRRAPA
PGTLQDGLCHSLDRGISGKGEGTEKSSQAKELLRCEKLDSKLANIDYLRKKMSLEDKEDNLCPVLKPKMTAGSHECLPGNPVRPTGGQQE
PPPASESRAFVSSTHAAQMSAVSFVPLKALTGRVDSGTEKPGLVAPESPVRKSPSEYKLEGRSVSCLKPIEGTLDIALLSGPQASKTELP
SPESAQSPSPSGDVRASVPPVLPSSSGKKNDTTSARELSPSSLKMNKSYLLEPWFLPPSRGLQNSPAVSLPDPEFKRDRKGPHPTARSPG
TVMESNPQQREGSSPKHQDHTTDPKLLTCLGQNLHSPDLARPRCPLPPEASPSREKPGLRESSERGPPTARSERSAARADTCREPSMELC
FPETAKTSDNSKNLLSVGRTHPDFYTQTQAMEKAWAPGGKTNHKDGPGEARPPPRDNSSLHSAGIPCEKELGKVRRGVEPKPEALLARRS
LQPPGIESEKSEKLSSFPSLQKDGAKEPERKEQPLQRHPSSIPPPPLTAKDLSSPAARQHCSSPSHASGREPGAKPSTAEPSSSPQDPPK
PVAAHSESSSHKPRPGPDPGPPKTKHPDRSLSSQKPSVGATKGKEPATQSLGGSSREGKGHSKSGPDVFPATPGSQNKASDGIGQGEGGP
SVPLHTDRAPLDAKPQPTSGGRPLEVLEKPVHLPRPGHPGPSEPADQKLSAVGEKQTLSPKHPKPSTVKDCPTLCKQTDNRQTDKSPSQP
AANTDRRAEGKKCTEALYAPAEGDKLEAGLSFVHSENRLKGAERPAAGVGKGFPEARGKGPGPQKPPTEADKPNGMKRSPSATGQSSFRS
TALPEKSLSCSSSFPETRAGVREASAASSDTSSAKAAGGMLELPAPSNRDHRKAQPAGEGRTHMTKSDSLPSFRVSTLPLESHHPDPNTM

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>66562_66562_2_PLXNB2-MAST4_PLXNB2_chr22_50722030_ENST00000359337_MAST4_chr5_66195778_ENST00000404260_length(transcript)=12462nt_BP=2679nt
CCCGGGCGCCATCGAGCCTTGGCGGCGGACGTGCAGAGAATCTCGATGCTGGCCTGGAGCAGAAACTGAGCTGGACCACTGGAGCCTCGG
TGAGGGGGTGCGGGGGGCAATGGCACTGCAGCTCTGGGCCCTGACCCTGCTGGGCCTGCTGGGCGCAGGTGCCAGCCTGAGGCCCCGCAA
GCTGGACTTCTTCCGCAGCGAGAAAGAGCTGAACCACCTGGCTGTGGATGAGGCCTCAGGCGTGGTGTACCTGGGGGCGGTGAATGCCCT
CTACCAGCTGGATGCGAAGCTGCAGCTGGAGCAGCAGGTGGCCACGGGCCCGGCCCTGGACAACAAGAAGTGCACGCCGCCCATCGAGGC
CAGCCAGTGCCATGAGGCTGAGATGACTGACAATGTCAACCAGCTGCTGCTGCTCGACCCTCCCAGGAAGCGCCTGGTGGAGTGCGGCAG
CCTCTTCAAGGGCATCTGCGCTCTGCGCGCCCTGAGCAACATCTCCCTCCGCCTGTTCTACGAGGACGGCAGCGGGGAGAAGTCTTTCGT
GGCCAGCAATGATGAGGGCGTGGCCACAGTGGGGCTGGTGAGCTCCACGGGTCCTGGTGGTGACCGCGTGCTGTTTGTGGGCAAAGGCAA
TGGGCCACACGACAACGGCATCATCGTGAGCACTCGGCTGTTGGACCGGACTGACAGCAGGGAGGCCTTTGAAGCCTACACGGACCACGC
CACCTACAAGGCCGGCTACCTGTCCACCAACACACAGCAGTTCGTGGCGGCCTTCGAGGACGGCCCCTACGTCTTCTTTGTCTTCAACCA
GCAGGACAAGCACCCGGCCCGGAACCGCACGCTGCTGGCACGCATGTGCAGAGAAGACCCCAACTACTACTCCTACCTGGAGATGGACCT
GCAGTGCCGGGACCCCGACATCCACGCCGCTGCCTTTGGCACCTGCCTGGCCGCCTCCGTGGCTGCGCCTGGCTCTGGCAGGGTGCTATA
TGCTGTCTTCAGCAGAGACAGCCGGAGCAGTGGGGGGCCCGGTGCGGGCCTCTGCCTGTTCCCGCTGGACAAGGTGCACGCCAAGATGGA
GGCCAACCGCAACGCCTGTTACACAGGCACCCGGGAGGCCCGTGACATCTTCTACAAGCCCTTCCACGGCGATATCCAGTGCGGCGGCCA
CGCGCCGGGCTCCAGCAAGAGCTTCCCATGTGGCTCGGAGCACCTGCCCTACCCGCTGGGCAGCCGCGACGGGCTCAGAGGCACAGCCGT
GCTGCAGCGTGGAGGCCTGAACCTCACGGCCGTGACGGTCGCCGCCGAGAACAACCACACTGTTGCTTTTCTGGGCACCTCTGATGGCCG
GATCCTCAAGGTGTACCTCACCCCAGATGGCACCTCCTCAGAGTACGACTCTATCCTTGTGGAGATAAACAAGAGAGTCAAGCGCGACCT
GGTACTGTCTGGAGACCTGGGCAGCCTGTACGCCATGACCCAGGACAAGGTGTTCCGGCTGCCGGTGCAGGAGTGCCTGAGCTACCCGAC
CTGCACCCAGTGCCGCGACTCCCAGGACCCCTACTGCGGCTGGTGCGTCGTCGAGGGACGATGCACCCGGAAGGCCGAGTGTCCGCGGGC
CGAGGAGGCCAGCCACTGGCTGTGGAGCCGAAGCAAGTCCTGCGTGGCCGTCACCAGCGCCCAGCCACAGAACATGAGCCGGCGGGCCCA
GGGGGAGGTGCAGCTGACCGTCAGCCCCCTCCCTGCCCTGAGCGAGGAGGACGAGTTGCTGTGCCTTTTTGGGGAGTCGCCGCCACACCC
CGCCCGCGTGGAGGGCGAGGCCGTCATCTGCAACTCCCCAAGCAGCATCCCCGTCACACCGCCAGGCCAGGACCACGTGGCCGTGACCAT
CCAGCTCCTCCTTAGACGAGGCAACATCTTCCTCACGTCCTACCAGTACCCCTTCTACGACTGCCGCCAGGCCATGAGCCTGGAGGAGAA
CCTGCCGTGCATCTCCTGCGTGAGCAACCGCTGGACCTGCCAGTGGGACCTGCGCTACCACGAGTGCCGGGAGGCTTCGCCCAACCCTGA
GGACGGCATCGTCCGTGCCCACATGGAGGACAGCTGTCCCCAGTTCCTGGGACCCAGCCCCCTGGTGATCCCCATGAACCACGAGACAGA
TGTGAACTTCCAGGGCAAGAACCTGGACACCGTGAAGGGTTCCTCCCTGCACGTGGGCAGTGACTTGCTCAAGTTCATGGAGCCGGTGAC
CATGCAGGAATCTGGGACCTTCGCCTTTCGGACCCCAAAGCTGTCCCACGATGCCAACGAGACGCTGCCCCTGCACCTCTACGTCAAGTC
TTACGGCAAGAATATCGACAGCAAGCTCCATGTGACCCTCTACAACTGCTCCTTTGGCCGCAGCGACTGCAGCCTGTGCCGGGCCGCTAA
CCCCGACTACAGGTGTGCGTGGTGCGGGGGCCAGAGCAGGTGCGTGTATGAGGCCCTGTGCAACACCACCTCCGAGTGCCCGCCGCCCGT
CATCACCAGGATCCAGCCTGAGACGGGCCCCCTGGGTGGGGGCATCCGCATCACCATCCTGGGGTCCAATTTGGGCGTCCAAGCAGGGGA
CATCCAGAGGATCTCTGTGGCCGGCCGGAACTGCTCCTTTCAGCCGGAACGTTACTCCGTGTCCACCCGAAGGAGCTGAGTCTCCCCAGA
AGAGGAAGTTTTTGCCGAACAAGCAACCGGAAAAGCTTAATAGGCAATGGGCAGTCACCAGCATTGCCTCGACCACACTCACCTCTCTCT
GCTCATGCAGGAAATAGCCCTCAAGATAGTCCAAGAAATTTCTCCCCCAGTGCCTCAGCCCATTTTTCATTTGCACGGAGTCTCAATAGG
ACTGATGGACGCCGCTGGTCGTTGGCTTCTCTCCCTTCCTCTGGCTATGGGACAAACACACCCAGCTCTACGGTCTCTTCATCCTGTTCC
TCCCAGGAGAAGTTGCATCAGTTACCATACCAACCAACACCAGACGAGTTACACTTCTTATCAAAACATTTCTGTACCACCGAAAGCATC
GCCACTGAGAACAGATGCAGGAACACGCCGATGCGCCCCCGTTCCCGAAGTCTGAGCCCTGGACGTTCTCCCGCCTGCTGTGACCATGAA
ATAATTATGATGAACCATGTCTACAAAGAAAGGTTCCCAAAGGCTACAGCTCAGATGGAAGAACGTCTAAAGGAAATTATCACCAGCTAC
TCTCCTGACAACGTTCTACCCTTAGCAGATGGAGTGCTTAGTTTCACTCACCACCAGATTATTGAACTGGCTCGAGATTGCTTGGATAAA
TCCCACCAGGGCCTCATCACCTCACGATACTTCCTTGAATTACAGCACAAATTAGATAAGTTGCTACAGGAGGCTCATGATCGTTCAGAA
AGTGGAGAATTGGCATTTATTAAACAACTAGTTCGAAAGATCCTAATTGTTATTGCCCGCCCTGCTCGGTTATTAGAGTGCCTGGAATTT
GATCCGGAAGAATTTTACTACCTATTGGAAGCAGCAGAAGGCCATGCCAAAGAAGGACAGGGTATTAAAACCGACATTCCCAGGTACATC
ATTAGCCAACTGGGACTCAATAAGGATCCCTTGGAAGAAATGGCTCATTTGGGAAACTACGATAGTGGGACAGCAGAAACACCAGAAACA
GATGAATCAGTGAGTAGCTCTAATGCCTCCCTGAAACTTCGAAGGAAACCTCGGGAAAGTGATTTTGAAACGATTAAATTGATTAGCAAT
GGAGCCTATGGGGCAGTCTACTTTGTTCGGCATAAAGAATCCCGGCAGAGGTTTGCCATGAAGAAGATTAATAAACAGAACCTCATCCTT
CGAAACCAGATCCAGCAGGCCTTTGTGGAGCGGGATATCCTGACTTTTGCAGAAAACCCCTTTGTTGTCAGCATGTATTGCTCCTTTGAA
ACAAGGCGCCACTTGTGCATGGTCATGGAATATGTGGAAGGGGGAGACTGTGCTACTTTAATGAAAAACATGGGTCCTCTCCCTGTTGAT
ATGGCCAGAATGTACTTTGCTGAGACGGTCTTGGCCTTGGAATATTTACATAATTATGGAATTGTACACAGGGATTTGAAACCAGACAAC
TTGTTGGTTACCTCCATGGGGCACATAAAGCTGACAGATTTTGGATTATCTAAGGTGGGACTAATGAGCATGACTACCAACCTTTACGAG
GGTCATATTGAGAAGGATGCTAGAGAGTTCCTGGATAAACAGGTCTGTGGCACACCTGAATACATTGCACCAGAAGTGATTCTGAGGCAG
GGTTATGGAAAGCCGGTGGACTGGTGGGCCATGGGGATTATCCTCTATGAATTTCTGGTTGGATGCGTGCCATTCTTTGGGGATACTCCA
GAGGAGCTATTTGGACAAGTCATCAGTGATGAGATCAACTGGCCTGAGAAGGATGAGGCACCCCCACCTGATGCCCAGGATCTGATTACC
TTACTCCTCAGGCAGAATCCCCTGGAGAGGCTGGGAACAGGTGGTGCATATGAAGTCAAACAGCATCGATTCTTCCGTTCTTTAGACTGG
AACAGTTTGCTGAGACAGAAGGCAGAATTTATTCCCCAACTGGAATCTGAGGATGACACAAGTTATTTTGATACTCGGTCTGAGAAGTAT
CATCATATGGAAACGGAGGAAGAAGATGACACAAATGATGAAGACTTTAATGTGGAAATAAGGCAGTTTTCTTCATGTTCACACAGGTTT
TCAAAAGTTTTCAGCAGTATAGATCGAATCACTCAGAATTCAGCAGAAGAGAAGGAAGACTCTGTGGACAAAACCAAAAGCACCACCTTG
CCATCCACAGAAACACTGAGCTGGAGTTCAGAATATTCTGAAATGCAACAGCTATCAACATCCAACTCTTCAGATACTGAAAGCAACAGA
CATAAACTCAGTTCTGGCCTACTTCCCAAACTGGCTATTTCAACAGAGGGAGAGCAAGATGAAGCTGCCTCCTGCCCTGGAGACCCCCAT
GAGGAGCCAGGAAAGCCAGCCCTTCCTCCTGAAGAGTGTGCCCAGGAGGAGCCTGAGGTCACCACCCCAGCCAGCACCATCAGCAGCTCC
ACCCTGTCAGTTGGCAGTTTTTCAGAGCACTTGGATCAGATAAATGGACGAAGCGAGTGTGTGGACAGTACAGATAATTCCTCAAAGCCA
TCCAGTGAACCCGCTTCTCACATGGCTCGGCAGCGATTAGAAAGCACAGAAAAAAAGAAAATCTCGGGGAAAGTCACAAAGTCCCTCTCT
GCCAGTGCTCTTTCCCTCATGATCCCAGGAGATATGTTTGCTGTTTCCCCTCTGGGAAGTCCAATGTCTCCCCATTCCCTGTCCTCGGAC
CCTTCTTCTTCACGAGATTCCTCTCCCAGCCGAGATTCCTCAGCAGCTTCTGCCAGTCCACATCAGCCGATTGTGATCCACAGTTCGGGG
AAGAACTACGGCTTTACCATCCGAGCCATCCGGGTGTATGTGGGAGACAGTGACATCTATACAGTGCACCATATCGTCTGGAATGTAGAA
GAAGGAAGTCCGGCATGCCAGGCAGGACTGAAGGCTGGAGATCTTATCACTCACATCAATGGAGAACCAGTGCATGGACTTGTCCACACA
GAAGTTATAGAACTCCTACTGAAGAGTGGGAATAAGGTGTCAATCACTACTACCCCATTTGAAAACACATCAATCAAAACTGGACCAGCC
AGGAGAAACAGCTATAAGAGCCGGATGGTGAGGCGGAGCAAGAAATCCAAGAAGAAAGAAAGTCTCGAAAGGAGGAGATCTCTTTTCAAA
AAGCTAGCCAAGCAGCCTTCTCCTTTACTCCACACCAGCCGAAGTTTCTCCTGCTTGAACAGATCCCTGTCATCGGGTGAGAGCCTCCCA
GGTTCCCCCACTCATAGCTTGTCTCCCCGGTCTCCAACACCAAGCTACCGCTCCACCCCTGACTTCCCATCTGGTACTAATTCCTCCCAG
AGCAGCTCCCCTAGTTCTAGTGCCCCCAATTCCCCAGCAGGGTCCGGGCACATCCGGCCCAGCACTCTCCACGGTCTTGCACCCAAACTC
GGCGGGCAGCGGTACCGGTCCGGAAGGCGAAAGTCCGCCGGCAACATCCCACTGTCCCCGCTGGCCCGGACGCCCTCTCCAACCCCGCAA
CCCACCTCCCCGCAGCGGTCACCATCCCCTCTTCTGGGACACTCACTGGGCAATTCCAAGATCGCGCAAGCCTTTCCCAGCAAGATGCAC
TCCCCGCCCACCATCGTCAGACACATCGTGAGGCCCAAGAGTGCGGAGCCCCCCAGGTCCCCGCTGCTCAAGCGCGTGCAGTCCGAGGAG
AAGCTGTCGCCCTCTTACGGCAGTGACAAGAAGCACCTGTGCTCCCGCAAGCACAGCCTGGAGGTGACCCAAGAGGAGGTGCAGCGGGAG
CAGTCCCAGCGGGAGGCGCCGCTGCAGAGCCTGGATGAGAACGTGTGCGACGTGCCGCCGCTCAGCCGCGCCCGGCCAGTGGAGCAAGGC
TGCCTGAAACGCCCAGTCTCCCGGAAGGTGGGCCGCCAGGAGTCTGTGGACGACCTGGACCGCGACAAGCTGAAGGCCAAGGTGGTGGTG
AAGAAAGCAGACGGCTTCCCAGAGAAACAGGAATCCCACCAGAAATCCCATGGACCCGGGAGTGATTTGGAAAACTTTGCTCTGTTTAAG
CTGGAAGAGAGAGAGAAGAAAGTCTATCCGAAGGCTGTGGAAAGGTCAAGTACTTTTGAAAACAAAGCGTCTATGCAGGAGGCGCCACCG
CTGGGCAGCCTGCTGAAGGATGCTCTTCACAAGCAGGCCAGCGTGCGCGCCAGCGAGGGTGCGATGTCGGATGGCCGGGTGCCTGCGGAG
CACCGCCAGGGTGGCGGGGACTTCAGACGGGCCCCCGCTCCTGGCACCCTCCAGGATGGTCTCTGCCACTCCCTCGACAGGGGCATCTCT
GGGAAGGGGGAAGGCACGGAGAAGTCCTCCCAGGCCAAGGAGCTTCTCCGATGTGAAAAGTTAGACAGCAAGCTGGCCAACATCGATTAC
CTCCGAAAGAAAATGTCACTTGAGGACAAAGAGGACAACCTCTGCCCTGTGCTGAAGCCCAAGATGACAGCTGGCTCCCACGAATGCCTG
CCAGGGAACCCAGTCCGACCCACGGGTGGGCAGCAGGAGCCCCCGCCGGCTTCTGAGAGCCGAGCTTTTGTCAGCAGCACCCATGCAGCT
CAGATGAGTGCCGTCTCTTTTGTTCCCCTCAAGGCCTTAACAGGCCGGGTGGACAGTGGAACGGAGAAGCCTGGCTTGGTTGCTCCTGAG
TCCCCTGTTAGGAAGAGCCCCTCCGAGTATAAGCTGGAAGGTAGGTCTGTCTCATGCCTGAAGCCGATCGAGGGCACTCTGGACATTGCT
CTCCTGTCCGGACCTCAGGCCTCCAAGACAGAACTGCCTTCCCCAGAGTCTGCACAGAGCCCCAGCCCAAGTGGTGACGTGAGGGCCTCT
GTGCCACCAGTTCTCCCCAGCAGCAGTGGGAAAAAGAACGATACCACCAGTGCAAGAGAGCTTTCTCCTTCCAGCTTAAAGATGAATAAA
TCCTACCTGCTGGAGCCTTGGTTCCTGCCCCCCAGCCGAGGTCTCCAGAATTCACCAGCAGTTTCCCTGCCTGACCCAGAGTTCAAGAGG
GACAGGAAAGGTCCCCATCCTACTGCCAGGAGCCCTGGAACAGTCATGGAAAGCAATCCCCAACAGAGAGAGGGCAGCTCCCCTAAACAC
CAAGACCACACCACTGACCCCAAGCTTCTGACCTGCCTGGGGCAGAACCTCCACAGCCCTGACCTGGCCAGGCCACGCTGCCCGCTCCCA
CCTGAAGCTTCCCCCTCAAGGGAGAAGCCAGGCCTGAGGGAATCGTCTGAAAGAGGCCCTCCCACAGCCAGAAGCGAGCGCTCTGCTGCG
AGGGCTGACACATGCAGAGAGCCCTCCATGGAACTGTGCTTTCCAGAAACTGCGAAAACCAGTGACAACTCCAAAAATCTCCTCTCTGTG
GGAAGGACCCACCCAGATTTCTATACACAGACCCAGGCCATGGAGAAAGCATGGGCGCCGGGTGGGAAAACGAACCACAAAGATGGCCCA
GGTGAGGCGAGGCCCCCGCCCAGAGACAACTCCTCTCTGCACTCAGCTGGAATTCCCTGTGAGAAGGAGCTGGGCAAGGTGAGGCGTGGC
GTGGAACCCAAGCCCGAAGCGCTTCTTGCCAGGCGGTCTCTGCAGCCACCTGGAATTGAGAGTGAGAAGAGTGAAAAGCTCTCCAGTTTC
CCATCTTTGCAGAAAGATGGTGCCAAGGAACCTGAAAGGAAGGAGCAGCCTCTACAAAGGCATCCCAGCAGCATCCCTCCGCCCCCTCTG
ACGGCCAAAGACCTGTCCAGCCCGGCTGCCAGGCAGCATTGCAGTTCCCCAAGCCACGCTTCTGGCAGAGAGCCGGGGGCCAAGCCCAGC
ACTGCAGAGCCCAGCTCGAGCCCCCAGGACCCTCCCAAGCCTGTTGCTGCGCACAGTGAAAGCAGCAGCCACAAGCCCCGGCCTGGCCCT
GACCCGGGCCCTCCAAAGACTAAGCACCCCGACCGGTCCCTCTCCTCTCAGAAACCAAGTGTCGGGGCCACAAAGGGCAAAGAGCCTGCC
ACTCAGTCCCTCGGTGGCTCTAGCAGAGAGGGGAAGGGCCACAGTAAGAGTGGGCCGGATGTGTTTCCTGCTACCCCAGGCTCCCAGAAC
AAAGCCAGCGATGGGATTGGCCAGGGAGAAGGTGGGCCCTCTGTCCCACTGCACACTGACAGGGCTCCTCTAGACGCCAAGCCACAACCC
ACCAGTGGTGGGCGGCCCCTGGAGGTGCTGGAGAAGCCTGTGCATTTGCCAAGGCCGGGACACCCAGGGCCTAGTGAGCCAGCGGACCAG
AAACTGTCCGCTGTTGGTGAAAAGCAAACCCTGTCTCCAAAGCACCCCAAACCATCCACTGTGAAAGATTGCCCCACCCTGTGCAAACAG
ACAGACAACAGACAGACAGACAAAAGCCCGAGTCAGCCGGCCGCCAACACCGACAGAAGGGCGGAAGGGAAGAAATGCACTGAAGCACTT
TATGCTCCAGCAGAGGGCGACAAGCTCGAGGCCGGCCTTTCCTTTGTGCATAGCGAGAACCGGTTGAAAGGCGCGGAGCGGCCAGCCGCG
GGGGTGGGGAAGGGCTTCCCTGAGGCCAGAGGGAAAGGGCCCGGTCCCCAGAAGCCACCGACGGAGGCAGACAAGCCCAATGGCATGAAA
CGGTCCCCCTCAGCCACTGGGCAGAGTTCTTTCCGATCCACGGCCCTCCCGGAAAAGTCTCTGAGCTGCTCCTCCAGCTTCCCTGAAACC
AGGGCCGGAGTTAGAGAGGCCTCTGCAGCCAGCAGCGACACCTCTTCTGCCAAGGCCGCCGGGGGCATGCTGGAGCTTCCAGCCCCCAGC
AACAGGGACCATAGGAAGGCTCAGCCTGCCGGGGAGGGCCGAACCCACATGACAAAGAGTGACTCCCTGCCCTCCTTCCGGGTCTCCACC
CTGCCTCTGGAGTCACACCACCCCGACCCAAACACCATGGGCGGGGCCAGCCACCGGGACAGGGCTCTCTCGGTGACTGCCACCGTAGGG
GAAACCAAAGGGAAGGACCCTGCCCCAGCCCAGCCTCCCCCAGCTAGGAAACAGAACGTGGGCAGAGACGTGACCAAGCCATCCCCAGCC
CCAAACACTGACCGCCCCATCTCTCTTTCTAATGAGAAGGACTTTGTGGTACGGCAGAGGCGGGGGAAAGAGAGTTTGCGTAGCAGCCCT
CACAAAAAGGCCTTGTAACGGGGAGGGCCCAGGGGCAGGACTGTGGAGACCCGTCCTGAACGGGCGACTGTGTCTTGACTACCTTTCAAA
ACCAGCACTGTGTGGGAATGTCCGCCAGGCAGAGCTCGGAGCCTCATTGAGACAGGGGAGAGAGAAAGACAAAGAGGGGACCTTCTTCCA
GATGCCTTCCCAGTTGTAACCGGTAAAACTGTTACCAGATAGTGTTTGTACAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTACCTTTAC
AGTTGAGGGTTGTTGAGGAAAATGATTTTCTTTGTAAATATATAGCATCGTGTTTGGTTTGGGATGTAGAGTCTATACCTGGCTGCTGAT
TGCGTCGTTTACTACAGCTTTTTTTAAATAAGATTTTTGCTTTACCATTTATCATAATGTAGTAATGAAGCAAAATGGTCAAAACTGGGT
GTGTGTGAACAGAGATACACCCATATTCGTGTATATACACATCCACCTACATGTTTTGGTCTGTGGTTTAAGAGACTATTTCAAGGTTCC
ATTTTTATAAGCTAAAACATTCTAAGTTAAGATGGAAGAAAGCCCTAAACACAGTAGATTCTGAGTTTTTATGTGTATTTTAACCAGAGT
TTCTGATAGTACTGTATCTGGCTACCTATATTTCCAGATCTAAAGCAAGAACTACTCTAAGTACTGCATTTGGAATCCTCCTCCATTAGG
AATGGCCAGGACAAGTGGAGCTAGCCATTTTCATTACACGGCCATCCCAATGGACACTGGATCCCTGGTCCAACTGTCTAAAAGGCCAGT
TGTTCCTTTCTGTGGATGTGGATGTCTGGCCTTCACCTGAGGTAGAGCGGGGACTATAAACACACATCAACTTTCTTTCTGTTTGCTTTC
TTTTCCTTCTTTTCAAACTCTTAAACTCAGGCCTTTATGCTGTGAGTGACTAGTCCAAGAAGCACACATTTTGTAGTAGTCCTGCACCAG
CCCTGCTCTTGAATAAAAAGGAAAATTACTGGCTGCACCCAAATCTTCTAGTACTTGAGTAATAAGCATCAGGCATTGGAAGAGGTTTTA
AATTTGCTTTTTTGAGGAAAAGAACTGGGGGTGGATTTTGGCATCGTAGCATATCGATTAAAGAATAATCAGGACATCAGATACATTTTA
ATACATAGCTGGGGCCTTATGTTGTAGATGAAGCTTGCTGTTTTTAGCAAGTTCCTGGGTTTCACATTCATTTCTGCTGCATCTAGTAGC
TCCACACATTTCATAACCTGATCTCTTTATTTGTATGCAAAAAATACTGTCTTAATACAGAGCAGCATTTTTGTAACAAAGAGACTCGCT
GGAGCTATTTGGTGCTTGAATGTGACCATCCTTTTTACTTTTGCTAAGCCTTATTTAAATTTTGTATACCGTGGAATATGTAGAATTTGT
CAAATCATTTTAGTGCTGAAGGTTTTTGATTTCTTGTTTTTGTTTCTGTTGTTGCAGTTTCTTTGGTGGCTTGTTTTGTATTGTAAGATG
GCACTTGCTGATATAAATACTAAGGCACTAAGAGAAAATACAGATAAGTATTTATAAGTTGCTTGGGAACCATAGCAGAATTTTTTGTTT
GGTTTTGTAAGAGAAAAAAAATTACCAATAAATAACTGATCTAGCACCCAAACTCTCTTGGGGGATGTCTTAGTATCTTCACGCTATAAA
ATTGTTCATCTAAGCACAGCATCATCTTATGGCCTTATGGATTGTAAATCTTCTAGTGAGGCTATAAACTCCACTCTGAAAACAAAGGCA
TAACTTAACCGACTGCTCAGTTGTCCTTCGTTGTAAAATGAATTGGCTTTGGGAAAAAGGAAAAAAACAAACAAAAAAAGAAAAAGAAAA
AAGCCTCCTCCTTGCCCCTAATTTTTTTTTCCCATATGGTTTTAGCCATTCCCCATCACTATATTGTGAAGCTGTAAAAATATATATATA
TACTTTACAAGAGTTTACTAATGGATTTCAAAACTGGTCTCAACGTTTATAATACATATCTGTGTTTGGCAGTTGTCATAACCCAATCCT
ACATTCAGCCATCGGGACAAGTCTGTCGGGGAGGTAGTTCATGGTTTACAAGCCTTTGCTTTTTAACTGTCCAATTTCCTTTAAAGCACA
ACTAGCTATTTGTTTACAAATGATATTTTTATGTATATTTTGTATAGTGTATCATCATTTTTGCCAAATATGTTTTTCATTATAAATGAG
TAAAGAGTACTTAAGGTTGCATTCATGTATTACATGTTTGTTGTTGTAAACCTCTCCAATCAGCTGGTAGAAATTCTCCTCATTGTGTTC
TATTTGGTCAGTCTCTGTGTGATTGTAGGATGTGCTCCTTGGTAGTACTCCCAGCTGTAGATTTACCAGCTTAAAAGTTTGTTAGGATCT
GTGCAATAAAGTGTTTGCAGTCTTATTTTCTCTAAGAAATTCCTTATGGACGTCATAATTGTTGTATATTGAACAAAATATTTATACTTA

>66562_66562_2_PLXNB2-MAST4_PLXNB2_chr22_50722030_ENST00000359337_MAST4_chr5_66195778_ENST00000404260_length(amino acids)=2425AA_BP=13
MLLSAGTLLRVHPKELSLPRRGSFCRTSNRKSLIGNGQSPALPRPHSPLSAHAGNSPQDSPRNFSPSASAHFSFARSLNRTDGRRWSLAS
LPSSGYGTNTPSSTVSSSCSSQEKLHQLPYQPTPDELHFLSKHFCTTESIATENRCRNTPMRPRSRSLSPGRSPACCDHEIIMMNHVYKE
RFPKATAQMEERLKEIITSYSPDNVLPLADGVLSFTHHQIIELARDCLDKSHQGLITSRYFLELQHKLDKLLQEAHDRSESGELAFIKQL
VRKILIVIARPARLLECLEFDPEEFYYLLEAAEGHAKEGQGIKTDIPRYIISQLGLNKDPLEEMAHLGNYDSGTAETPETDESVSSSNAS
LKLRRKPRESDFETIKLISNGAYGAVYFVRHKESRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVSMYCSFETRRHLCMVME
YVEGGDCATLMKNMGPLPVDMARMYFAETVLALEYLHNYGIVHRDLKPDNLLVTSMGHIKLTDFGLSKVGLMSMTTNLYEGHIEKDAREF
LDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEINWPEKDEAPPPDAQDLITLLLRQNPLER
LGTGGAYEVKQHRFFRSLDWNSLLRQKAEFIPQLESEDDTSYFDTRSEKYHHMETEEEDDTNDEDFNVEIRQFSSCSHRFSKVFSSIDRI
TQNSAEEKEDSVDKTKSTTLPSTETLSWSSEYSEMQQLSTSNSSDTESNRHKLSSGLLPKLAISTEGEQDEAASCPGDPHEEPGKPALPP
EECAQEEPEVTTPASTISSSTLSVGSFSEHLDQINGRSECVDSTDNSSKPSSEPASHMARQRLESTEKKKISGKVTKSLSASALSLMIPG
DMFAVSPLGSPMSPHSLSSDPSSSRDSSPSRDSSAASASPHQPIVIHSSGKNYGFTIRAIRVYVGDSDIYTVHHIVWNVEEGSPACQAGL
KAGDLITHINGEPVHGLVHTEVIELLLKSGNKVSITTTPFENTSIKTGPARRNSYKSRMVRRSKKSKKKESLERRRSLFKKLAKQPSPLL
HTSRSFSCLNRSLSSGESLPGSPTHSLSPRSPTPSYRSTPDFPSGTNSSQSSSPSSSAPNSPAGSGHIRPSTLHGLAPKLGGQRYRSGRR
KSAGNIPLSPLARTPSPTPQPTSPQRSPSPLLGHSLGNSKIAQAFPSKMHSPPTIVRHIVRPKSAEPPRSPLLKRVQSEEKLSPSYGSDK
KHLCSRKHSLEVTQEEVQREQSQREAPLQSLDENVCDVPPLSRARPVEQGCLKRPVSRKVGRQESVDDLDRDKLKAKVVVKKADGFPEKQ
ESHQKSHGPGSDLENFALFKLEEREKKVYPKAVERSSTFENKASMQEAPPLGSLLKDALHKQASVRASEGAMSDGRVPAEHRQGGGDFRR
APAPGTLQDGLCHSLDRGISGKGEGTEKSSQAKELLRCEKLDSKLANIDYLRKKMSLEDKEDNLCPVLKPKMTAGSHECLPGNPVRPTGG
QQEPPPASESRAFVSSTHAAQMSAVSFVPLKALTGRVDSGTEKPGLVAPESPVRKSPSEYKLEGRSVSCLKPIEGTLDIALLSGPQASKT
ELPSPESAQSPSPSGDVRASVPPVLPSSSGKKNDTTSARELSPSSLKMNKSYLLEPWFLPPSRGLQNSPAVSLPDPEFKRDRKGPHPTAR
SPGTVMESNPQQREGSSPKHQDHTTDPKLLTCLGQNLHSPDLARPRCPLPPEASPSREKPGLRESSERGPPTARSERSAARADTCREPSM
ELCFPETAKTSDNSKNLLSVGRTHPDFYTQTQAMEKAWAPGGKTNHKDGPGEARPPPRDNSSLHSAGIPCEKELGKVRRGVEPKPEALLA
RRSLQPPGIESEKSEKLSSFPSLQKDGAKEPERKEQPLQRHPSSIPPPPLTAKDLSSPAARQHCSSPSHASGREPGAKPSTAEPSSSPQD
PPKPVAAHSESSSHKPRPGPDPGPPKTKHPDRSLSSQKPSVGATKGKEPATQSLGGSSREGKGHSKSGPDVFPATPGSQNKASDGIGQGE
GGPSVPLHTDRAPLDAKPQPTSGGRPLEVLEKPVHLPRPGHPGPSEPADQKLSAVGEKQTLSPKHPKPSTVKDCPTLCKQTDNRQTDKSP
SQPAANTDRRAEGKKCTEALYAPAEGDKLEAGLSFVHSENRLKGAERPAAGVGKGFPEARGKGPGPQKPPTEADKPNGMKRSPSATGQSS
FRSTALPEKSLSCSSSFPETRAGVREASAASSDTSSAKAAGGMLELPAPSNRDHRKAQPAGEGRTHMTKSDSLPSFRVSTLPLESHHPDP

--------------------------------------------------------------
>66562_66562_3_PLXNB2-MAST4_PLXNB2_chr22_50722030_ENST00000359337_MAST4_chr5_66195778_ENST00000406039_length(transcript)=2754nt_BP=2679nt
CCCGGGCGCCATCGAGCCTTGGCGGCGGACGTGCAGAGAATCTCGATGCTGGCCTGGAGCAGAAACTGAGCTGGACCACTGGAGCCTCGG
TGAGGGGGTGCGGGGGGCAATGGCACTGCAGCTCTGGGCCCTGACCCTGCTGGGCCTGCTGGGCGCAGGTGCCAGCCTGAGGCCCCGCAA
GCTGGACTTCTTCCGCAGCGAGAAAGAGCTGAACCACCTGGCTGTGGATGAGGCCTCAGGCGTGGTGTACCTGGGGGCGGTGAATGCCCT
CTACCAGCTGGATGCGAAGCTGCAGCTGGAGCAGCAGGTGGCCACGGGCCCGGCCCTGGACAACAAGAAGTGCACGCCGCCCATCGAGGC
CAGCCAGTGCCATGAGGCTGAGATGACTGACAATGTCAACCAGCTGCTGCTGCTCGACCCTCCCAGGAAGCGCCTGGTGGAGTGCGGCAG
CCTCTTCAAGGGCATCTGCGCTCTGCGCGCCCTGAGCAACATCTCCCTCCGCCTGTTCTACGAGGACGGCAGCGGGGAGAAGTCTTTCGT
GGCCAGCAATGATGAGGGCGTGGCCACAGTGGGGCTGGTGAGCTCCACGGGTCCTGGTGGTGACCGCGTGCTGTTTGTGGGCAAAGGCAA
TGGGCCACACGACAACGGCATCATCGTGAGCACTCGGCTGTTGGACCGGACTGACAGCAGGGAGGCCTTTGAAGCCTACACGGACCACGC
CACCTACAAGGCCGGCTACCTGTCCACCAACACACAGCAGTTCGTGGCGGCCTTCGAGGACGGCCCCTACGTCTTCTTTGTCTTCAACCA
GCAGGACAAGCACCCGGCCCGGAACCGCACGCTGCTGGCACGCATGTGCAGAGAAGACCCCAACTACTACTCCTACCTGGAGATGGACCT
GCAGTGCCGGGACCCCGACATCCACGCCGCTGCCTTTGGCACCTGCCTGGCCGCCTCCGTGGCTGCGCCTGGCTCTGGCAGGGTGCTATA
TGCTGTCTTCAGCAGAGACAGCCGGAGCAGTGGGGGGCCCGGTGCGGGCCTCTGCCTGTTCCCGCTGGACAAGGTGCACGCCAAGATGGA
GGCCAACCGCAACGCCTGTTACACAGGCACCCGGGAGGCCCGTGACATCTTCTACAAGCCCTTCCACGGCGATATCCAGTGCGGCGGCCA
CGCGCCGGGCTCCAGCAAGAGCTTCCCATGTGGCTCGGAGCACCTGCCCTACCCGCTGGGCAGCCGCGACGGGCTCAGAGGCACAGCCGT
GCTGCAGCGTGGAGGCCTGAACCTCACGGCCGTGACGGTCGCCGCCGAGAACAACCACACTGTTGCTTTTCTGGGCACCTCTGATGGCCG
GATCCTCAAGGTGTACCTCACCCCAGATGGCACCTCCTCAGAGTACGACTCTATCCTTGTGGAGATAAACAAGAGAGTCAAGCGCGACCT
GGTACTGTCTGGAGACCTGGGCAGCCTGTACGCCATGACCCAGGACAAGGTGTTCCGGCTGCCGGTGCAGGAGTGCCTGAGCTACCCGAC
CTGCACCCAGTGCCGCGACTCCCAGGACCCCTACTGCGGCTGGTGCGTCGTCGAGGGACGATGCACCCGGAAGGCCGAGTGTCCGCGGGC
CGAGGAGGCCAGCCACTGGCTGTGGAGCCGAAGCAAGTCCTGCGTGGCCGTCACCAGCGCCCAGCCACAGAACATGAGCCGGCGGGCCCA
GGGGGAGGTGCAGCTGACCGTCAGCCCCCTCCCTGCCCTGAGCGAGGAGGACGAGTTGCTGTGCCTTTTTGGGGAGTCGCCGCCACACCC
CGCCCGCGTGGAGGGCGAGGCCGTCATCTGCAACTCCCCAAGCAGCATCCCCGTCACACCGCCAGGCCAGGACCACGTGGCCGTGACCAT
CCAGCTCCTCCTTAGACGAGGCAACATCTTCCTCACGTCCTACCAGTACCCCTTCTACGACTGCCGCCAGGCCATGAGCCTGGAGGAGAA
CCTGCCGTGCATCTCCTGCGTGAGCAACCGCTGGACCTGCCAGTGGGACCTGCGCTACCACGAGTGCCGGGAGGCTTCGCCCAACCCTGA
GGACGGCATCGTCCGTGCCCACATGGAGGACAGCTGTCCCCAGTTCCTGGGACCCAGCCCCCTGGTGATCCCCATGAACCACGAGACAGA
TGTGAACTTCCAGGGCAAGAACCTGGACACCGTGAAGGGTTCCTCCCTGCACGTGGGCAGTGACTTGCTCAAGTTCATGGAGCCGGTGAC
CATGCAGGAATCTGGGACCTTCGCCTTTCGGACCCCAAAGCTGTCCCACGATGCCAACGAGACGCTGCCCCTGCACCTCTACGTCAAGTC
TTACGGCAAGAATATCGACAGCAAGCTCCATGTGACCCTCTACAACTGCTCCTTTGGCCGCAGCGACTGCAGCCTGTGCCGGGCCGCTAA
CCCCGACTACAGGTGTGCGTGGTGCGGGGGCCAGAGCAGGTGCGTGTATGAGGCCCTGTGCAACACCACCTCCGAGTGCCCGCCGCCCGT
CATCACCAGGATCCAGCCTGAGACGGGCCCCCTGGGTGGGGGCATCCGCATCACCATCCTGGGGTCCAATTTGGGCGTCCAAGCAGGGGA
CATCCAGAGGATCTCTGTGGCCGGCCGGAACTGCTCCTTTCAGCCGGAACGTTACTCCGTGTCCACCCGAAGGAGCTGAGTCTCCCCAGA

>66562_66562_3_PLXNB2-MAST4_PLXNB2_chr22_50722030_ENST00000359337_MAST4_chr5_66195778_ENST00000406039_length(amino acids)=872AA_BP=
MDHWSLGEGVRGAMALQLWALTLLGLLGAGASLRPRKLDFFRSEKELNHLAVDEASGVVYLGAVNALYQLDAKLQLEQQVATGPALDNKK
CTPPIEASQCHEAEMTDNVNQLLLLDPPRKRLVECGSLFKGICALRALSNISLRLFYEDGSGEKSFVASNDEGVATVGLVSSTGPGGDRV
LFVGKGNGPHDNGIIVSTRLLDRTDSREAFEAYTDHATYKAGYLSTNTQQFVAAFEDGPYVFFVFNQQDKHPARNRTLLARMCREDPNYY
SYLEMDLQCRDPDIHAAAFGTCLAASVAAPGSGRVLYAVFSRDSRSSGGPGAGLCLFPLDKVHAKMEANRNACYTGTREARDIFYKPFHG
DIQCGGHAPGSSKSFPCGSEHLPYPLGSRDGLRGTAVLQRGGLNLTAVTVAAENNHTVAFLGTSDGRILKVYLTPDGTSSEYDSILVEIN
KRVKRDLVLSGDLGSLYAMTQDKVFRLPVQECLSYPTCTQCRDSQDPYCGWCVVEGRCTRKAECPRAEEASHWLWSRSKSCVAVTSAQPQ
NMSRRAQGEVQLTVSPLPALSEEDELLCLFGESPPHPARVEGEAVICNSPSSIPVTPPGQDHVAVTIQLLLRRGNIFLTSYQYPFYDCRQ
AMSLEENLPCISCVSNRWTCQWDLRYHECREASPNPEDGIVRAHMEDSCPQFLGPSPLVIPMNHETDVNFQGKNLDTVKGSSLHVGSDLL
KFMEPVTMQESGTFAFRTPKLSHDANETLPLHLYVKSYGKNIDSKLHVTLYNCSFGRSDCSLCRAANPDYRCAWCGGQSRCVYEALCNTT

--------------------------------------------------------------
>66562_66562_4_PLXNB2-MAST4_PLXNB2_chr22_50722030_ENST00000359337_MAST4_chr5_66195778_ENST00000406374_length(transcript)=2827nt_BP=2679nt
CCCGGGCGCCATCGAGCCTTGGCGGCGGACGTGCAGAGAATCTCGATGCTGGCCTGGAGCAGAAACTGAGCTGGACCACTGGAGCCTCGG
TGAGGGGGTGCGGGGGGCAATGGCACTGCAGCTCTGGGCCCTGACCCTGCTGGGCCTGCTGGGCGCAGGTGCCAGCCTGAGGCCCCGCAA
GCTGGACTTCTTCCGCAGCGAGAAAGAGCTGAACCACCTGGCTGTGGATGAGGCCTCAGGCGTGGTGTACCTGGGGGCGGTGAATGCCCT
CTACCAGCTGGATGCGAAGCTGCAGCTGGAGCAGCAGGTGGCCACGGGCCCGGCCCTGGACAACAAGAAGTGCACGCCGCCCATCGAGGC
CAGCCAGTGCCATGAGGCTGAGATGACTGACAATGTCAACCAGCTGCTGCTGCTCGACCCTCCCAGGAAGCGCCTGGTGGAGTGCGGCAG
CCTCTTCAAGGGCATCTGCGCTCTGCGCGCCCTGAGCAACATCTCCCTCCGCCTGTTCTACGAGGACGGCAGCGGGGAGAAGTCTTTCGT
GGCCAGCAATGATGAGGGCGTGGCCACAGTGGGGCTGGTGAGCTCCACGGGTCCTGGTGGTGACCGCGTGCTGTTTGTGGGCAAAGGCAA
TGGGCCACACGACAACGGCATCATCGTGAGCACTCGGCTGTTGGACCGGACTGACAGCAGGGAGGCCTTTGAAGCCTACACGGACCACGC
CACCTACAAGGCCGGCTACCTGTCCACCAACACACAGCAGTTCGTGGCGGCCTTCGAGGACGGCCCCTACGTCTTCTTTGTCTTCAACCA
GCAGGACAAGCACCCGGCCCGGAACCGCACGCTGCTGGCACGCATGTGCAGAGAAGACCCCAACTACTACTCCTACCTGGAGATGGACCT
GCAGTGCCGGGACCCCGACATCCACGCCGCTGCCTTTGGCACCTGCCTGGCCGCCTCCGTGGCTGCGCCTGGCTCTGGCAGGGTGCTATA
TGCTGTCTTCAGCAGAGACAGCCGGAGCAGTGGGGGGCCCGGTGCGGGCCTCTGCCTGTTCCCGCTGGACAAGGTGCACGCCAAGATGGA
GGCCAACCGCAACGCCTGTTACACAGGCACCCGGGAGGCCCGTGACATCTTCTACAAGCCCTTCCACGGCGATATCCAGTGCGGCGGCCA
CGCGCCGGGCTCCAGCAAGAGCTTCCCATGTGGCTCGGAGCACCTGCCCTACCCGCTGGGCAGCCGCGACGGGCTCAGAGGCACAGCCGT
GCTGCAGCGTGGAGGCCTGAACCTCACGGCCGTGACGGTCGCCGCCGAGAACAACCACACTGTTGCTTTTCTGGGCACCTCTGATGGCCG
GATCCTCAAGGTGTACCTCACCCCAGATGGCACCTCCTCAGAGTACGACTCTATCCTTGTGGAGATAAACAAGAGAGTCAAGCGCGACCT
GGTACTGTCTGGAGACCTGGGCAGCCTGTACGCCATGACCCAGGACAAGGTGTTCCGGCTGCCGGTGCAGGAGTGCCTGAGCTACCCGAC
CTGCACCCAGTGCCGCGACTCCCAGGACCCCTACTGCGGCTGGTGCGTCGTCGAGGGACGATGCACCCGGAAGGCCGAGTGTCCGCGGGC
CGAGGAGGCCAGCCACTGGCTGTGGAGCCGAAGCAAGTCCTGCGTGGCCGTCACCAGCGCCCAGCCACAGAACATGAGCCGGCGGGCCCA
GGGGGAGGTGCAGCTGACCGTCAGCCCCCTCCCTGCCCTGAGCGAGGAGGACGAGTTGCTGTGCCTTTTTGGGGAGTCGCCGCCACACCC
CGCCCGCGTGGAGGGCGAGGCCGTCATCTGCAACTCCCCAAGCAGCATCCCCGTCACACCGCCAGGCCAGGACCACGTGGCCGTGACCAT
CCAGCTCCTCCTTAGACGAGGCAACATCTTCCTCACGTCCTACCAGTACCCCTTCTACGACTGCCGCCAGGCCATGAGCCTGGAGGAGAA
CCTGCCGTGCATCTCCTGCGTGAGCAACCGCTGGACCTGCCAGTGGGACCTGCGCTACCACGAGTGCCGGGAGGCTTCGCCCAACCCTGA
GGACGGCATCGTCCGTGCCCACATGGAGGACAGCTGTCCCCAGTTCCTGGGACCCAGCCCCCTGGTGATCCCCATGAACCACGAGACAGA
TGTGAACTTCCAGGGCAAGAACCTGGACACCGTGAAGGGTTCCTCCCTGCACGTGGGCAGTGACTTGCTCAAGTTCATGGAGCCGGTGAC
CATGCAGGAATCTGGGACCTTCGCCTTTCGGACCCCAAAGCTGTCCCACGATGCCAACGAGACGCTGCCCCTGCACCTCTACGTCAAGTC
TTACGGCAAGAATATCGACAGCAAGCTCCATGTGACCCTCTACAACTGCTCCTTTGGCCGCAGCGACTGCAGCCTGTGCCGGGCCGCTAA
CCCCGACTACAGGTGTGCGTGGTGCGGGGGCCAGAGCAGGTGCGTGTATGAGGCCCTGTGCAACACCACCTCCGAGTGCCCGCCGCCCGT
CATCACCAGGATCCAGCCTGAGACGGGCCCCCTGGGTGGGGGCATCCGCATCACCATCCTGGGGTCCAATTTGGGCGTCCAAGCAGGGGA
CATCCAGAGGATCTCTGTGGCCGGCCGGAACTGCTCCTTTCAGCCGGAACGTTACTCCGTGTCCACCCGAAGGAGCTGAGTCTCCCCAGA
AGAGGAAGTTTGATAGATTCCCAGAAGTGGAATTGCTTGGTCAAACGCCCTGTGTGTCCAAATGCTGGGAGAACATCACCCCTTGGATGA

>66562_66562_4_PLXNB2-MAST4_PLXNB2_chr22_50722030_ENST00000359337_MAST4_chr5_66195778_ENST00000406374_length(amino acids)=872AA_BP=
MDHWSLGEGVRGAMALQLWALTLLGLLGAGASLRPRKLDFFRSEKELNHLAVDEASGVVYLGAVNALYQLDAKLQLEQQVATGPALDNKK
CTPPIEASQCHEAEMTDNVNQLLLLDPPRKRLVECGSLFKGICALRALSNISLRLFYEDGSGEKSFVASNDEGVATVGLVSSTGPGGDRV
LFVGKGNGPHDNGIIVSTRLLDRTDSREAFEAYTDHATYKAGYLSTNTQQFVAAFEDGPYVFFVFNQQDKHPARNRTLLARMCREDPNYY
SYLEMDLQCRDPDIHAAAFGTCLAASVAAPGSGRVLYAVFSRDSRSSGGPGAGLCLFPLDKVHAKMEANRNACYTGTREARDIFYKPFHG
DIQCGGHAPGSSKSFPCGSEHLPYPLGSRDGLRGTAVLQRGGLNLTAVTVAAENNHTVAFLGTSDGRILKVYLTPDGTSSEYDSILVEIN
KRVKRDLVLSGDLGSLYAMTQDKVFRLPVQECLSYPTCTQCRDSQDPYCGWCVVEGRCTRKAECPRAEEASHWLWSRSKSCVAVTSAQPQ
NMSRRAQGEVQLTVSPLPALSEEDELLCLFGESPPHPARVEGEAVICNSPSSIPVTPPGQDHVAVTIQLLLRRGNIFLTSYQYPFYDCRQ
AMSLEENLPCISCVSNRWTCQWDLRYHECREASPNPEDGIVRAHMEDSCPQFLGPSPLVIPMNHETDVNFQGKNLDTVKGSSLHVGSDLL
KFMEPVTMQESGTFAFRTPKLSHDANETLPLHLYVKSYGKNIDSKLHVTLYNCSFGRSDCSLCRAANPDYRCAWCGGQSRCVYEALCNTT

--------------------------------------------------------------
>66562_66562_5_PLXNB2-MAST4_PLXNB2_chr22_50722031_ENST00000359337_MAST4_chr5_66195779_ENST00000403625_length(transcript)=12453nt_BP=2679nt
CCCGGGCGCCATCGAGCCTTGGCGGCGGACGTGCAGAGAATCTCGATGCTGGCCTGGAGCAGAAACTGAGCTGGACCACTGGAGCCTCGG
TGAGGGGGTGCGGGGGGCAATGGCACTGCAGCTCTGGGCCCTGACCCTGCTGGGCCTGCTGGGCGCAGGTGCCAGCCTGAGGCCCCGCAA
GCTGGACTTCTTCCGCAGCGAGAAAGAGCTGAACCACCTGGCTGTGGATGAGGCCTCAGGCGTGGTGTACCTGGGGGCGGTGAATGCCCT
CTACCAGCTGGATGCGAAGCTGCAGCTGGAGCAGCAGGTGGCCACGGGCCCGGCCCTGGACAACAAGAAGTGCACGCCGCCCATCGAGGC
CAGCCAGTGCCATGAGGCTGAGATGACTGACAATGTCAACCAGCTGCTGCTGCTCGACCCTCCCAGGAAGCGCCTGGTGGAGTGCGGCAG
CCTCTTCAAGGGCATCTGCGCTCTGCGCGCCCTGAGCAACATCTCCCTCCGCCTGTTCTACGAGGACGGCAGCGGGGAGAAGTCTTTCGT
GGCCAGCAATGATGAGGGCGTGGCCACAGTGGGGCTGGTGAGCTCCACGGGTCCTGGTGGTGACCGCGTGCTGTTTGTGGGCAAAGGCAA
TGGGCCACACGACAACGGCATCATCGTGAGCACTCGGCTGTTGGACCGGACTGACAGCAGGGAGGCCTTTGAAGCCTACACGGACCACGC
CACCTACAAGGCCGGCTACCTGTCCACCAACACACAGCAGTTCGTGGCGGCCTTCGAGGACGGCCCCTACGTCTTCTTTGTCTTCAACCA
GCAGGACAAGCACCCGGCCCGGAACCGCACGCTGCTGGCACGCATGTGCAGAGAAGACCCCAACTACTACTCCTACCTGGAGATGGACCT
GCAGTGCCGGGACCCCGACATCCACGCCGCTGCCTTTGGCACCTGCCTGGCCGCCTCCGTGGCTGCGCCTGGCTCTGGCAGGGTGCTATA
TGCTGTCTTCAGCAGAGACAGCCGGAGCAGTGGGGGGCCCGGTGCGGGCCTCTGCCTGTTCCCGCTGGACAAGGTGCACGCCAAGATGGA
GGCCAACCGCAACGCCTGTTACACAGGCACCCGGGAGGCCCGTGACATCTTCTACAAGCCCTTCCACGGCGATATCCAGTGCGGCGGCCA
CGCGCCGGGCTCCAGCAAGAGCTTCCCATGTGGCTCGGAGCACCTGCCCTACCCGCTGGGCAGCCGCGACGGGCTCAGAGGCACAGCCGT
GCTGCAGCGTGGAGGCCTGAACCTCACGGCCGTGACGGTCGCCGCCGAGAACAACCACACTGTTGCTTTTCTGGGCACCTCTGATGGCCG
GATCCTCAAGGTGTACCTCACCCCAGATGGCACCTCCTCAGAGTACGACTCTATCCTTGTGGAGATAAACAAGAGAGTCAAGCGCGACCT
GGTACTGTCTGGAGACCTGGGCAGCCTGTACGCCATGACCCAGGACAAGGTGTTCCGGCTGCCGGTGCAGGAGTGCCTGAGCTACCCGAC
CTGCACCCAGTGCCGCGACTCCCAGGACCCCTACTGCGGCTGGTGCGTCGTCGAGGGACGATGCACCCGGAAGGCCGAGTGTCCGCGGGC
CGAGGAGGCCAGCCACTGGCTGTGGAGCCGAAGCAAGTCCTGCGTGGCCGTCACCAGCGCCCAGCCACAGAACATGAGCCGGCGGGCCCA
GGGGGAGGTGCAGCTGACCGTCAGCCCCCTCCCTGCCCTGAGCGAGGAGGACGAGTTGCTGTGCCTTTTTGGGGAGTCGCCGCCACACCC
CGCCCGCGTGGAGGGCGAGGCCGTCATCTGCAACTCCCCAAGCAGCATCCCCGTCACACCGCCAGGCCAGGACCACGTGGCCGTGACCAT
CCAGCTCCTCCTTAGACGAGGCAACATCTTCCTCACGTCCTACCAGTACCCCTTCTACGACTGCCGCCAGGCCATGAGCCTGGAGGAGAA
CCTGCCGTGCATCTCCTGCGTGAGCAACCGCTGGACCTGCCAGTGGGACCTGCGCTACCACGAGTGCCGGGAGGCTTCGCCCAACCCTGA
GGACGGCATCGTCCGTGCCCACATGGAGGACAGCTGTCCCCAGTTCCTGGGACCCAGCCCCCTGGTGATCCCCATGAACCACGAGACAGA
TGTGAACTTCCAGGGCAAGAACCTGGACACCGTGAAGGGTTCCTCCCTGCACGTGGGCAGTGACTTGCTCAAGTTCATGGAGCCGGTGAC
CATGCAGGAATCTGGGACCTTCGCCTTTCGGACCCCAAAGCTGTCCCACGATGCCAACGAGACGCTGCCCCTGCACCTCTACGTCAAGTC
TTACGGCAAGAATATCGACAGCAAGCTCCATGTGACCCTCTACAACTGCTCCTTTGGCCGCAGCGACTGCAGCCTGTGCCGGGCCGCTAA
CCCCGACTACAGGTGTGCGTGGTGCGGGGGCCAGAGCAGGTGCGTGTATGAGGCCCTGTGCAACACCACCTCCGAGTGCCCGCCGCCCGT
CATCACCAGGATCCAGCCTGAGACGGGCCCCCTGGGTGGGGGCATCCGCATCACCATCCTGGGGTCCAATTTGGGCGTCCAAGCAGGGGA
CATCCAGAGGATCTCTGTGGCCGGCCGGAACTGCTCCTTTCAGCCGGAACGTTACTCCGTGTCCACCCGAAGGAGCTGAGTCTCCCCAGA
AGAGGAAGTTTTTGCCGAACAAGCAACCGGAAAAGCTTAATAGGCAATGGGCAGTCACCAGCATTGCCTCGACCACACTCACCTCTCTCT
GCTCATGCAGGAAATAGCCCTCAAGATAGTCCAAGAAATTTCTCCCCCAGTGCCTCAGCCCATTTTTCATTTGCACGGAGGACTGATGGA
CGCCGCTGGTCGTTGGCTTCTCTCCCTTCCTCTGGCTATGGGACAAACACACCCAGCTCTACGGTCTCTTCATCCTGTTCCTCCCAGGAG
AAGTTGCATCAGTTACCATACCAACCAACACCAGACGAGTTACACTTCTTATCAAAACATTTCTGTACCACCGAAAGCATCGCCACTGAG
AACAGATGCAGGAACACGCCGATGCGCCCCCGTTCCCGAAGTCTGAGCCCTGGACGTTCTCCCGCCTGCTGTGACCATGAAATAATTATG
ATGAACCATGTCTACAAAGAAAGGTTCCCAAAGGCTACAGCTCAGATGGAAGAACGTCTAAAGGAAATTATCACCAGCTACTCTCCTGAC
AACGTTCTACCCTTAGCAGATGGAGTGCTTAGTTTCACTCACCACCAGATTATTGAACTGGCTCGAGATTGCTTGGATAAATCCCACCAG
GGCCTCATCACCTCACGATACTTCCTTGAATTACAGCACAAATTAGATAAGTTGCTACAGGAGGCTCATGATCGTTCAGAAAGTGGAGAA
TTGGCATTTATTAAACAACTAGTTCGAAAGATCCTAATTGTTATTGCCCGCCCTGCTCGGTTATTAGAGTGCCTGGAATTTGATCCGGAA
GAATTTTACTACCTATTGGAAGCAGCAGAAGGCCATGCCAAAGAAGGACAGGGTATTAAAACCGACATTCCCAGGTACATCATTAGCCAA
CTGGGACTCAATAAGGATCCCTTGGAAGAAATGGCTCATTTGGGAAACTACGATAGTGGGACAGCAGAAACACCAGAAACAGATGAATCA
GTGAGTAGCTCTAATGCCTCCCTGAAACTTCGAAGGAAACCTCGGGAAAGTGATTTTGAAACGATTAAATTGATTAGCAATGGAGCCTAT
GGGGCAGTCTACTTTGTTCGGCATAAAGAATCCCGGCAGAGGTTTGCCATGAAGAAGATTAATAAACAGAACCTCATCCTTCGAAACCAG
ATCCAGCAGGCCTTTGTGGAGCGGGATATCCTGACTTTTGCAGAAAACCCCTTTGTTGTCAGCATGTATTGCTCCTTTGAAACAAGGCGC
CACTTGTGCATGGTCATGGAATATGTGGAAGGGGGAGACTGTGCTACTTTAATGAAAAACATGGGTCCTCTCCCTGTTGATATGGCCAGA
ATGTACTTTGCTGAGACGGTCTTGGCCTTGGAATATTTACATAATTATGGAATTGTACACAGGGATTTGAAACCAGACAACTTGTTGGTT
ACCTCCATGGGGCACATAAAGCTGACAGATTTTGGATTATCTAAGGTGGGACTAATGAGCATGACTACCAACCTTTACGAGGGTCATATT
GAGAAGGATGCTAGAGAGTTCCTGGATAAACAGGTCTGTGGCACACCTGAATACATTGCACCAGAAGTGATTCTGAGGCAGGGTTATGGA
AAGCCGGTGGACTGGTGGGCCATGGGGATTATCCTCTATGAATTTCTGGTTGGATGCGTGCCATTCTTTGGGGATACTCCAGAGGAGCTA
TTTGGACAAGTCATCAGTGATGAGATCAACTGGCCTGAGAAGGATGAGGCACCCCCACCTGATGCCCAGGATCTGATTACCTTACTCCTC
AGGCAGAATCCCCTGGAGAGGCTGGGAACAGGTGGTGCATATGAAGTCAAACAGCATCGATTCTTCCGTTCTTTAGACTGGAACAGTTTG
CTGAGACAGAAGGCAGAATTTATTCCCCAACTGGAATCTGAGGATGACACAAGTTATTTTGATACTCGGTCTGAGAAGTATCATCATATG
GAAACGGAGGAAGAAGATGACACAAATGATGAAGACTTTAATGTGGAAATAAGGCAGTTTTCTTCATGTTCACACAGGTTTTCAAAAGTT
TTCAGCAGTATAGATCGAATCACTCAGAATTCAGCAGAAGAGAAGGAAGACTCTGTGGACAAAACCAAAAGCACCACCTTGCCATCCACA
GAAACACTGAGCTGGAGTTCAGAATATTCTGAAATGCAACAGCTATCAACATCCAACTCTTCAGATACTGAAAGCAACAGACATAAACTC
AGTTCTGGCCTACTTCCCAAACTGGCTATTTCAACAGAGGGAGAGCAAGATGAAGCTGCCTCCTGCCCTGGAGACCCCCATGAGGAGCCA
GGAAAGCCAGCCCTTCCTCCTGAAGAGTGTGCCCAGGAGGAGCCTGAGGTCACCACCCCAGCCAGCACCATCAGCAGCTCCACCCTGTCA
GTTGGCAGTTTTTCAGAGCACTTGGATCAGATAAATGGACGAAGCGAGTGTGTGGACAGTACAGATAATTCCTCAAAGCCATCCAGTGAA
CCCGCTTCTCACATGGCTCGGCAGCGATTAGAAAGCACAGAAAAAAAGAAAATCTCGGGGAAAGTCACAAAGTCCCTCTCTGCCAGTGCT
CTTTCCCTCATGATCCCAGGAGATATGTTTGCTGTTTCCCCTCTGGGAAGTCCAATGTCTCCCCATTCCCTGTCCTCGGACCCTTCTTCT
TCACGAGATTCCTCTCCCAGCCGAGATTCCTCAGCAGCTTCTGCCAGTCCACATCAGCCGATTGTGATCCACAGTTCGGGGAAGAACTAC
GGCTTTACCATCCGAGCCATCCGGGTGTATGTGGGAGACAGTGACATCTATACAGTGCACCATATCGTCTGGAATGTAGAAGAAGGAAGT
CCGGCATGCCAGGCAGGACTGAAGGCTGGAGATCTTATCACTCACATCAATGGAGAACCAGTGCATGGACTTGTCCACACAGAAGTTATA
GAACTCCTACTGAAGAGTGGGAATAAGGTGTCAATCACTACTACCCCATTTGAAAACACATCAATCAAAACTGGACCAGCCAGGAGAAAC
AGCTATAAGAGCCGGATGGTGAGGCGGAGCAAGAAATCCAAGAAGAAAGAAAGTCTCGAAAGGAGGAGATCTCTTTTCAAAAAGCTAGCC
AAGCAGCCTTCTCCTTTACTCCACACCAGCCGAAGTTTCTCCTGCTTGAACAGATCCCTGTCATCGGGTGAGAGCCTCCCAGGTTCCCCC
ACTCATAGCTTGTCTCCCCGGTCTCCAACACCAAGCTACCGCTCCACCCCTGACTTCCCATCTGGTACTAATTCCTCCCAGAGCAGCTCC
CCTAGTTCTAGTGCCCCCAATTCCCCAGCAGGGTCCGGGCACATCCGGCCCAGCACTCTCCACGGTCTTGCACCCAAACTCGGCGGGCAG
CGGTACCGGTCCGGAAGGCGAAAGTCCGCCGGCAACATCCCACTGTCCCCGCTGGCCCGGACGCCCTCTCCAACCCCGCAACCCACCTCC
CCGCAGCGGTCACCATCCCCTCTTCTGGGACACTCACTGGGCAATTCCAAGATCGCGCAAGCCTTTCCCAGCAAGATGCACTCCCCGCCC
ACCATCGTCAGACACATCGTGAGGCCCAAGAGTGCGGAGCCCCCCAGGTCCCCGCTGCTCAAGCGCGTGCAGTCCGAGGAGAAGCTGTCG
CCCTCTTACGGCAGTGACAAGAAGCACCTGTGCTCCCGCAAGCACAGCCTGGAGGTGACCCAAGAGGAGGTGCAGCGGGAGCAGTCCCAG
CGGGAGGCGCCGCTGCAGAGCCTGGATGAGAACGTGTGCGACGTGCCGCCGCTCAGCCGCGCCCGGCCAGTGGAGCAAGGCTGCCTGAAA
CGCCCAGTCTCCCGGAAGGTGGGCCGCCAGGAGTCTGTGGACGACCTGGACCGCGACAAGCTGAAGGCCAAGGTGGTGGTGAAGAAAGCA
GACGGCTTCCCAGAGAAACAGGAATCCCACCAGAAATCCCATGGACCCGGGAGTGATTTGGAAAACTTTGCTCTGTTTAAGCTGGAAGAG
AGAGAGAAGAAAGTCTATCCGAAGGCTGTGGAAAGGTCAAGTACTTTTGAAAACAAAGCGTCTATGCAGGAGGCGCCACCGCTGGGCAGC
CTGCTGAAGGATGCTCTTCACAAGCAGGCCAGCGTGCGCGCCAGCGAGGGTGCGATGTCGGATGGCCGGGTGCCTGCGGAGCACCGCCAG
GGTGGCGGGGACTTCAGACGGGCCCCCGCTCCTGGCACCCTCCAGGATGGTCTCTGCCACTCCCTCGACAGGGGCATCTCTGGGAAGGGG
GAAGGCACGGAGAAGTCCTCCCAGGCCAAGGAGCTTCTCCGATGTGAAAAGTTAGACAGCAAGCTGGCCAACATCGATTACCTCCGAAAG
AAAATGTCACTTGAGGACAAAGAGGACAACCTCTGCCCTGTGCTGAAGCCCAAGATGACAGCTGGCTCCCACGAATGCCTGCCAGGGAAC
CCAGTCCGACCCACGGGTGGGCAGCAGGAGCCCCCGCCGGCTTCTGAGAGCCGAGCTTTTGTCAGCAGCACCCATGCAGCTCAGATGAGT
GCCGTCTCTTTTGTTCCCCTCAAGGCCTTAACAGGCCGGGTGGACAGTGGAACGGAGAAGCCTGGCTTGGTTGCTCCTGAGTCCCCTGTT
AGGAAGAGCCCCTCCGAGTATAAGCTGGAAGGTAGGTCTGTCTCATGCCTGAAGCCGATCGAGGGCACTCTGGACATTGCTCTCCTGTCC
GGACCTCAGGCCTCCAAGACAGAACTGCCTTCCCCAGAGTCTGCACAGAGCCCCAGCCCAAGTGGTGACGTGAGGGCCTCTGTGCCACCA
GTTCTCCCCAGCAGCAGTGGGAAAAAGAACGATACCACCAGTGCAAGAGAGCTTTCTCCTTCCAGCTTAAAGATGAATAAATCCTACCTG
CTGGAGCCTTGGTTCCTGCCCCCCAGCCGAGGTCTCCAGAATTCACCAGCAGTTTCCCTGCCTGACCCAGAGTTCAAGAGGGACAGGAAA
GGTCCCCATCCTACTGCCAGGAGCCCTGGAACAGTCATGGAAAGCAATCCCCAACAGAGAGAGGGCAGCTCCCCTAAACACCAAGACCAC
ACCACTGACCCCAAGCTTCTGACCTGCCTGGGGCAGAACCTCCACAGCCCTGACCTGGCCAGGCCACGCTGCCCGCTCCCACCTGAAGCT
TCCCCCTCAAGGGAGAAGCCAGGCCTGAGGGAATCGTCTGAAAGAGGCCCTCCCACAGCCAGAAGCGAGCGCTCTGCTGCGAGGGCTGAC
ACATGCAGAGAGCCCTCCATGGAACTGTGCTTTCCAGAAACTGCGAAAACCAGTGACAACTCCAAAAATCTCCTCTCTGTGGGAAGGACC
CACCCAGATTTCTATACACAGACCCAGGCCATGGAGAAAGCATGGGCGCCGGGTGGGAAAACGAACCACAAAGATGGCCCAGGTGAGGCG
AGGCCCCCGCCCAGAGACAACTCCTCTCTGCACTCAGCTGGAATTCCCTGTGAGAAGGAGCTGGGCAAGGTGAGGCGTGGCGTGGAACCC
AAGCCCGAAGCGCTTCTTGCCAGGCGGTCTCTGCAGCCACCTGGAATTGAGAGTGAGAAGAGTGAAAAGCTCTCCAGTTTCCCATCTTTG
CAGAAAGATGGTGCCAAGGAACCTGAAAGGAAGGAGCAGCCTCTACAAAGGCATCCCAGCAGCATCCCTCCGCCCCCTCTGACGGCCAAA
GACCTGTCCAGCCCGGCTGCCAGGCAGCATTGCAGTTCCCCAAGCCACGCTTCTGGCAGAGAGCCGGGGGCCAAGCCCAGCACTGCAGAG
CCCAGCTCGAGCCCCCAGGACCCTCCCAAGCCTGTTGCTGCGCACAGTGAAAGCAGCAGCCACAAGCCCCGGCCTGGCCCTGACCCGGGC
CCTCCAAAGACTAAGCACCCCGACCGGTCCCTCTCCTCTCAGAAACCAAGTGTCGGGGCCACAAAGGGCAAAGAGCCTGCCACTCAGTCC
CTCGGTGGCTCTAGCAGAGAGGGGAAGGGCCACAGTAAGAGTGGGCCGGATGTGTTTCCTGCTACCCCAGGCTCCCAGAACAAAGCCAGC
GATGGGATTGGCCAGGGAGAAGGTGGGCCCTCTGTCCCACTGCACACTGACAGGGCTCCTCTAGACGCCAAGCCACAACCCACCAGTGGT
GGGCGGCCCCTGGAGGTGCTGGAGAAGCCTGTGCATTTGCCAAGGCCGGGACACCCAGGGCCTAGTGAGCCAGCGGACCAGAAACTGTCC
GCTGTTGGTGAAAAGCAAACCCTGTCTCCAAAGCACCCCAAACCATCCACTGTGAAAGATTGCCCCACCCTGTGCAAACAGACAGACAAC
AGACAGACAGACAAAAGCCCGAGTCAGCCGGCCGCCAACACCGACAGAAGGGCGGAAGGGAAGAAATGCACTGAAGCACTTTATGCTCCA
GCAGAGGGCGACAAGCTCGAGGCCGGCCTTTCCTTTGTGCATAGCGAGAACCGGTTGAAAGGCGCGGAGCGGCCAGCCGCGGGGGTGGGG
AAGGGCTTCCCTGAGGCCAGAGGGAAAGGGCCCGGTCCCCAGAAGCCACCGACGGAGGCAGACAAGCCCAATGGCATGAAACGGTCCCCC
TCAGCCACTGGGCAGAGTTCTTTCCGATCCACGGCCCTCCCGGAAAAGTCTCTGAGCTGCTCCTCCAGCTTCCCTGAAACCAGGGCCGGA
GTTAGAGAGGCCTCTGCAGCCAGCAGCGACACCTCTTCTGCCAAGGCCGCCGGGGGCATGCTGGAGCTTCCAGCCCCCAGCAACAGGGAC
CATAGGAAGGCTCAGCCTGCCGGGGAGGGCCGAACCCACATGACAAAGAGTGACTCCCTGCCCTCCTTCCGGGTCTCCACCCTGCCTCTG
GAGTCACACCACCCCGACCCAAACACCATGGGCGGGGCCAGCCACCGGGACAGGGCTCTCTCGGTGACTGCCACCGTAGGGGAAACCAAA
GGGAAGGACCCTGCCCCAGCCCAGCCTCCCCCAGCTAGGAAACAGAACGTGGGCAGAGACGTGACCAAGCCATCCCCAGCCCCAAACACT
GACCGCCCCATCTCTCTTTCTAATGAGAAGGACTTTGTGGTACGGCAGAGGCGGGGGAAAGAGAGTTTGCGTAGCAGCCCTCACAAAAAG
GCCTTGTAACGGGGAGGGCCCAGGGGCAGGACTGTGGAGACCCGTCCTGAACGGGCGACTGTGTCTTGACTACCTTTCAAAACCAGCACT
GTGTGGGAATGTCCGCCAGGCAGAGCTCGGAGCCTCATTGAGACAGGGGAGAGAGAAAGACAAAGAGGGGACCTTCTTCCAGATGCCTTC
CCAGTTGTAACCGGTAAAACTGTTACCAGATAGTGTTTGTACAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTACCTTTACAGTTGAGGG
TTGTTGAGGAAAATGATTTTCTTTGTAAATATATAGCATCGTGTTTGGTTTGGGATGTAGAGTCTATACCTGGCTGCTGATTGCGTCGTT
TACTACAGCTTTTTTTAAATAAGATTTTTGCTTTACCATTTATCATAATGTAGTAATGAAGCAAAATGGTCAAAACTGGGTGTGTGTGAA
CAGAGATACACCCATATTCGTGTATATACACATCCACCTACATGTTTTGGTCTGTGGTTTAAGAGACTATTTCAAGGTTCCATTTTTATA
AGCTAAAACATTCTAAGTTAAGATGGAAGAAAGCCCTAAACACAGTAGATTCTGAGTTTTTATGTGTATTTTAACCAGAGTTTCTGATAG
TACTGTATCTGGCTACCTATATTTCCAGATCTAAAGCAAGAACTACTCTAAGTACTGCATTTGGAATCCTCCTCCATTAGGAATGGCCAG
GACAAGTGGAGCTAGCCATTTTCATTACACGGCCATCCCAATGGACACTGGATCCCTGGTCCAACTGTCTAAAAGGCCAGTTGTTCCTTT
CTGTGGATGTGGATGTCTGGCCTTCACCTGAGGTAGAGCGGGGACTATAAACACACATCAACTTTCTTTCTGTTTGCTTTCTTTTCCTTC
TTTTCAAACTCTTAAACTCAGGCCTTTATGCTGTGAGTGACTAGTCCAAGAAGCACACATTTTGTAGTAGTCCTGCACCAGCCCTGCTCT
TGAATAAAAAGGAAAATTACTGGCTGCACCCAAATCTTCTAGTACTTGAGTAATAAGCATCAGGCATTGGAAGAGGTTTTAAATTTGCTT
TTTTGAGGAAAAGAACTGGGGGTGGATTTTGGCATCGTAGCATATCGATTAAAGAATAATCAGGACATCAGATACATTTTAATACATAGC
TGGGGCCTTATGTTGTAGATGAAGCTTGCTGTTTTTAGCAAGTTCCTGGGTTTCACATTCATTTCTGCTGCATCTAGTAGCTCCACACAT
TTCATAACCTGATCTCTTTATTTGTATGCAAAAAATACTGTCTTAATACAGAGCAGCATTTTTGTAACAAAGAGACTCGCTGGAGCTATT
TGGTGCTTGAATGTGACCATCCTTTTTACTTTTGCTAAGCCTTATTTAAATTTTGTATACCGTGGAATATGTAGAATTTGTCAAATCATT
TTAGTGCTGAAGGTTTTTGATTTCTTGTTTTTGTTTCTGTTGTTGCAGTTTCTTTGGTGGCTTGTTTTGTATTGTAAGATGGCACTTGCT
GATATAAATACTAAGGCACTAAGAGAAAATACAGATAAGTATTTATAAGTTGCTTGGGAACCATAGCAGAATTTTTTGTTTGGTTTTGTA
AGAGAAAAAAAATTACCAATAAATAACTGATCTAGCACCCAAACTCTCTTGGGGGATGTCTTAGTATCTTCACGCTATAAAATTGTTCAT
CTAAGCACAGCATCATCTTATGGCCTTATGGATTGTAAATCTTCTAGTGAGGCTATAAACTCCACTCTGAAAACAAAGGCATAACTTAAC
CGACTGCTCAGTTGTCCTTCGTTGTAAAATGAATTGGCTTTGGGAAAAAGGAAAAAAACAAACAAAAAAAGAAAAAGAAAAAAGCCTCCT
CCTTGCCCCTAATTTTTTTTTCCCATATGGTTTTAGCCATTCCCCATCACTATATTGTGAAGCTGTAAAAATATATATATATACTTTACA
AGAGTTTACTAATGGATTTCAAAACTGGTCTCAACGTTTATAATACATATCTGTGTTTGGCAGTTGTCATAACCCAATCCTACATTCAGC
CATCGGGACAAGTCTGTCGGGGAGGTAGTTCATGGTTTACAAGCCTTTGCTTTTTAACTGTCCAATTTCCTTTAAAGCACAACTAGCTAT
TTGTTTACAAATGATATTTTTATGTATATTTTGTATAGTGTATCATCATTTTTGCCAAATATGTTTTTCATTATAAATGAGTAAAGAGTA
CTTAAGGTTGCATTCATGTATTACATGTTTGTTGTTGTAAACCTCTCCAATCAGCTGGTAGAAATTCTCCTCATTGTGTTCTATTTGGTC
AGTCTCTGTGTGATTGTAGGATGTGCTCCTTGGTAGTACTCCCAGCTGTAGATTTACCAGCTTAAAAGTTTGTTAGGATCTGTGCAATAA
AGTGTTTGCAGTCTTATTTTCTCTAAGAAATTCCTTATGGACGTCATAATTGTTGTATATTGAACAAAATATTTATACTTATGCAGTTGC

>66562_66562_5_PLXNB2-MAST4_PLXNB2_chr22_50722031_ENST00000359337_MAST4_chr5_66195779_ENST00000403625_length(amino acids)=2422AA_BP=13
MLLSAGTLLRVHPKELSLPRRGSFCRTSNRKSLIGNGQSPALPRPHSPLSAHAGNSPQDSPRNFSPSASAHFSFARRTDGRRWSLASLPS
SGYGTNTPSSTVSSSCSSQEKLHQLPYQPTPDELHFLSKHFCTTESIATENRCRNTPMRPRSRSLSPGRSPACCDHEIIMMNHVYKERFP
KATAQMEERLKEIITSYSPDNVLPLADGVLSFTHHQIIELARDCLDKSHQGLITSRYFLELQHKLDKLLQEAHDRSESGELAFIKQLVRK
ILIVIARPARLLECLEFDPEEFYYLLEAAEGHAKEGQGIKTDIPRYIISQLGLNKDPLEEMAHLGNYDSGTAETPETDESVSSSNASLKL
RRKPRESDFETIKLISNGAYGAVYFVRHKESRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVSMYCSFETRRHLCMVMEYVE
GGDCATLMKNMGPLPVDMARMYFAETVLALEYLHNYGIVHRDLKPDNLLVTSMGHIKLTDFGLSKVGLMSMTTNLYEGHIEKDAREFLDK
QVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEINWPEKDEAPPPDAQDLITLLLRQNPLERLGT
GGAYEVKQHRFFRSLDWNSLLRQKAEFIPQLESEDDTSYFDTRSEKYHHMETEEEDDTNDEDFNVEIRQFSSCSHRFSKVFSSIDRITQN
SAEEKEDSVDKTKSTTLPSTETLSWSSEYSEMQQLSTSNSSDTESNRHKLSSGLLPKLAISTEGEQDEAASCPGDPHEEPGKPALPPEEC
AQEEPEVTTPASTISSSTLSVGSFSEHLDQINGRSECVDSTDNSSKPSSEPASHMARQRLESTEKKKISGKVTKSLSASALSLMIPGDMF
AVSPLGSPMSPHSLSSDPSSSRDSSPSRDSSAASASPHQPIVIHSSGKNYGFTIRAIRVYVGDSDIYTVHHIVWNVEEGSPACQAGLKAG
DLITHINGEPVHGLVHTEVIELLLKSGNKVSITTTPFENTSIKTGPARRNSYKSRMVRRSKKSKKKESLERRRSLFKKLAKQPSPLLHTS
RSFSCLNRSLSSGESLPGSPTHSLSPRSPTPSYRSTPDFPSGTNSSQSSSPSSSAPNSPAGSGHIRPSTLHGLAPKLGGQRYRSGRRKSA
GNIPLSPLARTPSPTPQPTSPQRSPSPLLGHSLGNSKIAQAFPSKMHSPPTIVRHIVRPKSAEPPRSPLLKRVQSEEKLSPSYGSDKKHL
CSRKHSLEVTQEEVQREQSQREAPLQSLDENVCDVPPLSRARPVEQGCLKRPVSRKVGRQESVDDLDRDKLKAKVVVKKADGFPEKQESH
QKSHGPGSDLENFALFKLEEREKKVYPKAVERSSTFENKASMQEAPPLGSLLKDALHKQASVRASEGAMSDGRVPAEHRQGGGDFRRAPA
PGTLQDGLCHSLDRGISGKGEGTEKSSQAKELLRCEKLDSKLANIDYLRKKMSLEDKEDNLCPVLKPKMTAGSHECLPGNPVRPTGGQQE
PPPASESRAFVSSTHAAQMSAVSFVPLKALTGRVDSGTEKPGLVAPESPVRKSPSEYKLEGRSVSCLKPIEGTLDIALLSGPQASKTELP
SPESAQSPSPSGDVRASVPPVLPSSSGKKNDTTSARELSPSSLKMNKSYLLEPWFLPPSRGLQNSPAVSLPDPEFKRDRKGPHPTARSPG
TVMESNPQQREGSSPKHQDHTTDPKLLTCLGQNLHSPDLARPRCPLPPEASPSREKPGLRESSERGPPTARSERSAARADTCREPSMELC
FPETAKTSDNSKNLLSVGRTHPDFYTQTQAMEKAWAPGGKTNHKDGPGEARPPPRDNSSLHSAGIPCEKELGKVRRGVEPKPEALLARRS
LQPPGIESEKSEKLSSFPSLQKDGAKEPERKEQPLQRHPSSIPPPPLTAKDLSSPAARQHCSSPSHASGREPGAKPSTAEPSSSPQDPPK
PVAAHSESSSHKPRPGPDPGPPKTKHPDRSLSSQKPSVGATKGKEPATQSLGGSSREGKGHSKSGPDVFPATPGSQNKASDGIGQGEGGP
SVPLHTDRAPLDAKPQPTSGGRPLEVLEKPVHLPRPGHPGPSEPADQKLSAVGEKQTLSPKHPKPSTVKDCPTLCKQTDNRQTDKSPSQP
AANTDRRAEGKKCTEALYAPAEGDKLEAGLSFVHSENRLKGAERPAAGVGKGFPEARGKGPGPQKPPTEADKPNGMKRSPSATGQSSFRS
TALPEKSLSCSSSFPETRAGVREASAASSDTSSAKAAGGMLELPAPSNRDHRKAQPAGEGRTHMTKSDSLPSFRVSTLPLESHHPDPNTM

--------------------------------------------------------------
>66562_66562_6_PLXNB2-MAST4_PLXNB2_chr22_50722031_ENST00000359337_MAST4_chr5_66195779_ENST00000404260_length(transcript)=12462nt_BP=2679nt
CCCGGGCGCCATCGAGCCTTGGCGGCGGACGTGCAGAGAATCTCGATGCTGGCCTGGAGCAGAAACTGAGCTGGACCACTGGAGCCTCGG
TGAGGGGGTGCGGGGGGCAATGGCACTGCAGCTCTGGGCCCTGACCCTGCTGGGCCTGCTGGGCGCAGGTGCCAGCCTGAGGCCCCGCAA
GCTGGACTTCTTCCGCAGCGAGAAAGAGCTGAACCACCTGGCTGTGGATGAGGCCTCAGGCGTGGTGTACCTGGGGGCGGTGAATGCCCT
CTACCAGCTGGATGCGAAGCTGCAGCTGGAGCAGCAGGTGGCCACGGGCCCGGCCCTGGACAACAAGAAGTGCACGCCGCCCATCGAGGC
CAGCCAGTGCCATGAGGCTGAGATGACTGACAATGTCAACCAGCTGCTGCTGCTCGACCCTCCCAGGAAGCGCCTGGTGGAGTGCGGCAG
CCTCTTCAAGGGCATCTGCGCTCTGCGCGCCCTGAGCAACATCTCCCTCCGCCTGTTCTACGAGGACGGCAGCGGGGAGAAGTCTTTCGT
GGCCAGCAATGATGAGGGCGTGGCCACAGTGGGGCTGGTGAGCTCCACGGGTCCTGGTGGTGACCGCGTGCTGTTTGTGGGCAAAGGCAA
TGGGCCACACGACAACGGCATCATCGTGAGCACTCGGCTGTTGGACCGGACTGACAGCAGGGAGGCCTTTGAAGCCTACACGGACCACGC
CACCTACAAGGCCGGCTACCTGTCCACCAACACACAGCAGTTCGTGGCGGCCTTCGAGGACGGCCCCTACGTCTTCTTTGTCTTCAACCA
GCAGGACAAGCACCCGGCCCGGAACCGCACGCTGCTGGCACGCATGTGCAGAGAAGACCCCAACTACTACTCCTACCTGGAGATGGACCT
GCAGTGCCGGGACCCCGACATCCACGCCGCTGCCTTTGGCACCTGCCTGGCCGCCTCCGTGGCTGCGCCTGGCTCTGGCAGGGTGCTATA
TGCTGTCTTCAGCAGAGACAGCCGGAGCAGTGGGGGGCCCGGTGCGGGCCTCTGCCTGTTCCCGCTGGACAAGGTGCACGCCAAGATGGA
GGCCAACCGCAACGCCTGTTACACAGGCACCCGGGAGGCCCGTGACATCTTCTACAAGCCCTTCCACGGCGATATCCAGTGCGGCGGCCA
CGCGCCGGGCTCCAGCAAGAGCTTCCCATGTGGCTCGGAGCACCTGCCCTACCCGCTGGGCAGCCGCGACGGGCTCAGAGGCACAGCCGT
GCTGCAGCGTGGAGGCCTGAACCTCACGGCCGTGACGGTCGCCGCCGAGAACAACCACACTGTTGCTTTTCTGGGCACCTCTGATGGCCG
GATCCTCAAGGTGTACCTCACCCCAGATGGCACCTCCTCAGAGTACGACTCTATCCTTGTGGAGATAAACAAGAGAGTCAAGCGCGACCT
GGTACTGTCTGGAGACCTGGGCAGCCTGTACGCCATGACCCAGGACAAGGTGTTCCGGCTGCCGGTGCAGGAGTGCCTGAGCTACCCGAC
CTGCACCCAGTGCCGCGACTCCCAGGACCCCTACTGCGGCTGGTGCGTCGTCGAGGGACGATGCACCCGGAAGGCCGAGTGTCCGCGGGC
CGAGGAGGCCAGCCACTGGCTGTGGAGCCGAAGCAAGTCCTGCGTGGCCGTCACCAGCGCCCAGCCACAGAACATGAGCCGGCGGGCCCA
GGGGGAGGTGCAGCTGACCGTCAGCCCCCTCCCTGCCCTGAGCGAGGAGGACGAGTTGCTGTGCCTTTTTGGGGAGTCGCCGCCACACCC
CGCCCGCGTGGAGGGCGAGGCCGTCATCTGCAACTCCCCAAGCAGCATCCCCGTCACACCGCCAGGCCAGGACCACGTGGCCGTGACCAT
CCAGCTCCTCCTTAGACGAGGCAACATCTTCCTCACGTCCTACCAGTACCCCTTCTACGACTGCCGCCAGGCCATGAGCCTGGAGGAGAA
CCTGCCGTGCATCTCCTGCGTGAGCAACCGCTGGACCTGCCAGTGGGACCTGCGCTACCACGAGTGCCGGGAGGCTTCGCCCAACCCTGA
GGACGGCATCGTCCGTGCCCACATGGAGGACAGCTGTCCCCAGTTCCTGGGACCCAGCCCCCTGGTGATCCCCATGAACCACGAGACAGA
TGTGAACTTCCAGGGCAAGAACCTGGACACCGTGAAGGGTTCCTCCCTGCACGTGGGCAGTGACTTGCTCAAGTTCATGGAGCCGGTGAC
CATGCAGGAATCTGGGACCTTCGCCTTTCGGACCCCAAAGCTGTCCCACGATGCCAACGAGACGCTGCCCCTGCACCTCTACGTCAAGTC
TTACGGCAAGAATATCGACAGCAAGCTCCATGTGACCCTCTACAACTGCTCCTTTGGCCGCAGCGACTGCAGCCTGTGCCGGGCCGCTAA
CCCCGACTACAGGTGTGCGTGGTGCGGGGGCCAGAGCAGGTGCGTGTATGAGGCCCTGTGCAACACCACCTCCGAGTGCCCGCCGCCCGT
CATCACCAGGATCCAGCCTGAGACGGGCCCCCTGGGTGGGGGCATCCGCATCACCATCCTGGGGTCCAATTTGGGCGTCCAAGCAGGGGA
CATCCAGAGGATCTCTGTGGCCGGCCGGAACTGCTCCTTTCAGCCGGAACGTTACTCCGTGTCCACCCGAAGGAGCTGAGTCTCCCCAGA
AGAGGAAGTTTTTGCCGAACAAGCAACCGGAAAAGCTTAATAGGCAATGGGCAGTCACCAGCATTGCCTCGACCACACTCACCTCTCTCT
GCTCATGCAGGAAATAGCCCTCAAGATAGTCCAAGAAATTTCTCCCCCAGTGCCTCAGCCCATTTTTCATTTGCACGGAGTCTCAATAGG
ACTGATGGACGCCGCTGGTCGTTGGCTTCTCTCCCTTCCTCTGGCTATGGGACAAACACACCCAGCTCTACGGTCTCTTCATCCTGTTCC
TCCCAGGAGAAGTTGCATCAGTTACCATACCAACCAACACCAGACGAGTTACACTTCTTATCAAAACATTTCTGTACCACCGAAAGCATC
GCCACTGAGAACAGATGCAGGAACACGCCGATGCGCCCCCGTTCCCGAAGTCTGAGCCCTGGACGTTCTCCCGCCTGCTGTGACCATGAA
ATAATTATGATGAACCATGTCTACAAAGAAAGGTTCCCAAAGGCTACAGCTCAGATGGAAGAACGTCTAAAGGAAATTATCACCAGCTAC
TCTCCTGACAACGTTCTACCCTTAGCAGATGGAGTGCTTAGTTTCACTCACCACCAGATTATTGAACTGGCTCGAGATTGCTTGGATAAA
TCCCACCAGGGCCTCATCACCTCACGATACTTCCTTGAATTACAGCACAAATTAGATAAGTTGCTACAGGAGGCTCATGATCGTTCAGAA
AGTGGAGAATTGGCATTTATTAAACAACTAGTTCGAAAGATCCTAATTGTTATTGCCCGCCCTGCTCGGTTATTAGAGTGCCTGGAATTT
GATCCGGAAGAATTTTACTACCTATTGGAAGCAGCAGAAGGCCATGCCAAAGAAGGACAGGGTATTAAAACCGACATTCCCAGGTACATC
ATTAGCCAACTGGGACTCAATAAGGATCCCTTGGAAGAAATGGCTCATTTGGGAAACTACGATAGTGGGACAGCAGAAACACCAGAAACA
GATGAATCAGTGAGTAGCTCTAATGCCTCCCTGAAACTTCGAAGGAAACCTCGGGAAAGTGATTTTGAAACGATTAAATTGATTAGCAAT
GGAGCCTATGGGGCAGTCTACTTTGTTCGGCATAAAGAATCCCGGCAGAGGTTTGCCATGAAGAAGATTAATAAACAGAACCTCATCCTT
CGAAACCAGATCCAGCAGGCCTTTGTGGAGCGGGATATCCTGACTTTTGCAGAAAACCCCTTTGTTGTCAGCATGTATTGCTCCTTTGAA
ACAAGGCGCCACTTGTGCATGGTCATGGAATATGTGGAAGGGGGAGACTGTGCTACTTTAATGAAAAACATGGGTCCTCTCCCTGTTGAT
ATGGCCAGAATGTACTTTGCTGAGACGGTCTTGGCCTTGGAATATTTACATAATTATGGAATTGTACACAGGGATTTGAAACCAGACAAC
TTGTTGGTTACCTCCATGGGGCACATAAAGCTGACAGATTTTGGATTATCTAAGGTGGGACTAATGAGCATGACTACCAACCTTTACGAG
GGTCATATTGAGAAGGATGCTAGAGAGTTCCTGGATAAACAGGTCTGTGGCACACCTGAATACATTGCACCAGAAGTGATTCTGAGGCAG
GGTTATGGAAAGCCGGTGGACTGGTGGGCCATGGGGATTATCCTCTATGAATTTCTGGTTGGATGCGTGCCATTCTTTGGGGATACTCCA
GAGGAGCTATTTGGACAAGTCATCAGTGATGAGATCAACTGGCCTGAGAAGGATGAGGCACCCCCACCTGATGCCCAGGATCTGATTACC
TTACTCCTCAGGCAGAATCCCCTGGAGAGGCTGGGAACAGGTGGTGCATATGAAGTCAAACAGCATCGATTCTTCCGTTCTTTAGACTGG
AACAGTTTGCTGAGACAGAAGGCAGAATTTATTCCCCAACTGGAATCTGAGGATGACACAAGTTATTTTGATACTCGGTCTGAGAAGTAT
CATCATATGGAAACGGAGGAAGAAGATGACACAAATGATGAAGACTTTAATGTGGAAATAAGGCAGTTTTCTTCATGTTCACACAGGTTT
TCAAAAGTTTTCAGCAGTATAGATCGAATCACTCAGAATTCAGCAGAAGAGAAGGAAGACTCTGTGGACAAAACCAAAAGCACCACCTTG
CCATCCACAGAAACACTGAGCTGGAGTTCAGAATATTCTGAAATGCAACAGCTATCAACATCCAACTCTTCAGATACTGAAAGCAACAGA
CATAAACTCAGTTCTGGCCTACTTCCCAAACTGGCTATTTCAACAGAGGGAGAGCAAGATGAAGCTGCCTCCTGCCCTGGAGACCCCCAT
GAGGAGCCAGGAAAGCCAGCCCTTCCTCCTGAAGAGTGTGCCCAGGAGGAGCCTGAGGTCACCACCCCAGCCAGCACCATCAGCAGCTCC
ACCCTGTCAGTTGGCAGTTTTTCAGAGCACTTGGATCAGATAAATGGACGAAGCGAGTGTGTGGACAGTACAGATAATTCCTCAAAGCCA
TCCAGTGAACCCGCTTCTCACATGGCTCGGCAGCGATTAGAAAGCACAGAAAAAAAGAAAATCTCGGGGAAAGTCACAAAGTCCCTCTCT
GCCAGTGCTCTTTCCCTCATGATCCCAGGAGATATGTTTGCTGTTTCCCCTCTGGGAAGTCCAATGTCTCCCCATTCCCTGTCCTCGGAC
CCTTCTTCTTCACGAGATTCCTCTCCCAGCCGAGATTCCTCAGCAGCTTCTGCCAGTCCACATCAGCCGATTGTGATCCACAGTTCGGGG
AAGAACTACGGCTTTACCATCCGAGCCATCCGGGTGTATGTGGGAGACAGTGACATCTATACAGTGCACCATATCGTCTGGAATGTAGAA
GAAGGAAGTCCGGCATGCCAGGCAGGACTGAAGGCTGGAGATCTTATCACTCACATCAATGGAGAACCAGTGCATGGACTTGTCCACACA
GAAGTTATAGAACTCCTACTGAAGAGTGGGAATAAGGTGTCAATCACTACTACCCCATTTGAAAACACATCAATCAAAACTGGACCAGCC
AGGAGAAACAGCTATAAGAGCCGGATGGTGAGGCGGAGCAAGAAATCCAAGAAGAAAGAAAGTCTCGAAAGGAGGAGATCTCTTTTCAAA
AAGCTAGCCAAGCAGCCTTCTCCTTTACTCCACACCAGCCGAAGTTTCTCCTGCTTGAACAGATCCCTGTCATCGGGTGAGAGCCTCCCA
GGTTCCCCCACTCATAGCTTGTCTCCCCGGTCTCCAACACCAAGCTACCGCTCCACCCCTGACTTCCCATCTGGTACTAATTCCTCCCAG
AGCAGCTCCCCTAGTTCTAGTGCCCCCAATTCCCCAGCAGGGTCCGGGCACATCCGGCCCAGCACTCTCCACGGTCTTGCACCCAAACTC
GGCGGGCAGCGGTACCGGTCCGGAAGGCGAAAGTCCGCCGGCAACATCCCACTGTCCCCGCTGGCCCGGACGCCCTCTCCAACCCCGCAA
CCCACCTCCCCGCAGCGGTCACCATCCCCTCTTCTGGGACACTCACTGGGCAATTCCAAGATCGCGCAAGCCTTTCCCAGCAAGATGCAC
TCCCCGCCCACCATCGTCAGACACATCGTGAGGCCCAAGAGTGCGGAGCCCCCCAGGTCCCCGCTGCTCAAGCGCGTGCAGTCCGAGGAG
AAGCTGTCGCCCTCTTACGGCAGTGACAAGAAGCACCTGTGCTCCCGCAAGCACAGCCTGGAGGTGACCCAAGAGGAGGTGCAGCGGGAG
CAGTCCCAGCGGGAGGCGCCGCTGCAGAGCCTGGATGAGAACGTGTGCGACGTGCCGCCGCTCAGCCGCGCCCGGCCAGTGGAGCAAGGC
TGCCTGAAACGCCCAGTCTCCCGGAAGGTGGGCCGCCAGGAGTCTGTGGACGACCTGGACCGCGACAAGCTGAAGGCCAAGGTGGTGGTG
AAGAAAGCAGACGGCTTCCCAGAGAAACAGGAATCCCACCAGAAATCCCATGGACCCGGGAGTGATTTGGAAAACTTTGCTCTGTTTAAG
CTGGAAGAGAGAGAGAAGAAAGTCTATCCGAAGGCTGTGGAAAGGTCAAGTACTTTTGAAAACAAAGCGTCTATGCAGGAGGCGCCACCG
CTGGGCAGCCTGCTGAAGGATGCTCTTCACAAGCAGGCCAGCGTGCGCGCCAGCGAGGGTGCGATGTCGGATGGCCGGGTGCCTGCGGAG
CACCGCCAGGGTGGCGGGGACTTCAGACGGGCCCCCGCTCCTGGCACCCTCCAGGATGGTCTCTGCCACTCCCTCGACAGGGGCATCTCT
GGGAAGGGGGAAGGCACGGAGAAGTCCTCCCAGGCCAAGGAGCTTCTCCGATGTGAAAAGTTAGACAGCAAGCTGGCCAACATCGATTAC
CTCCGAAAGAAAATGTCACTTGAGGACAAAGAGGACAACCTCTGCCCTGTGCTGAAGCCCAAGATGACAGCTGGCTCCCACGAATGCCTG
CCAGGGAACCCAGTCCGACCCACGGGTGGGCAGCAGGAGCCCCCGCCGGCTTCTGAGAGCCGAGCTTTTGTCAGCAGCACCCATGCAGCT
CAGATGAGTGCCGTCTCTTTTGTTCCCCTCAAGGCCTTAACAGGCCGGGTGGACAGTGGAACGGAGAAGCCTGGCTTGGTTGCTCCTGAG
TCCCCTGTTAGGAAGAGCCCCTCCGAGTATAAGCTGGAAGGTAGGTCTGTCTCATGCCTGAAGCCGATCGAGGGCACTCTGGACATTGCT
CTCCTGTCCGGACCTCAGGCCTCCAAGACAGAACTGCCTTCCCCAGAGTCTGCACAGAGCCCCAGCCCAAGTGGTGACGTGAGGGCCTCT
GTGCCACCAGTTCTCCCCAGCAGCAGTGGGAAAAAGAACGATACCACCAGTGCAAGAGAGCTTTCTCCTTCCAGCTTAAAGATGAATAAA
TCCTACCTGCTGGAGCCTTGGTTCCTGCCCCCCAGCCGAGGTCTCCAGAATTCACCAGCAGTTTCCCTGCCTGACCCAGAGTTCAAGAGG
GACAGGAAAGGTCCCCATCCTACTGCCAGGAGCCCTGGAACAGTCATGGAAAGCAATCCCCAACAGAGAGAGGGCAGCTCCCCTAAACAC
CAAGACCACACCACTGACCCCAAGCTTCTGACCTGCCTGGGGCAGAACCTCCACAGCCCTGACCTGGCCAGGCCACGCTGCCCGCTCCCA
CCTGAAGCTTCCCCCTCAAGGGAGAAGCCAGGCCTGAGGGAATCGTCTGAAAGAGGCCCTCCCACAGCCAGAAGCGAGCGCTCTGCTGCG
AGGGCTGACACATGCAGAGAGCCCTCCATGGAACTGTGCTTTCCAGAAACTGCGAAAACCAGTGACAACTCCAAAAATCTCCTCTCTGTG
GGAAGGACCCACCCAGATTTCTATACACAGACCCAGGCCATGGAGAAAGCATGGGCGCCGGGTGGGAAAACGAACCACAAAGATGGCCCA
GGTGAGGCGAGGCCCCCGCCCAGAGACAACTCCTCTCTGCACTCAGCTGGAATTCCCTGTGAGAAGGAGCTGGGCAAGGTGAGGCGTGGC
GTGGAACCCAAGCCCGAAGCGCTTCTTGCCAGGCGGTCTCTGCAGCCACCTGGAATTGAGAGTGAGAAGAGTGAAAAGCTCTCCAGTTTC
CCATCTTTGCAGAAAGATGGTGCCAAGGAACCTGAAAGGAAGGAGCAGCCTCTACAAAGGCATCCCAGCAGCATCCCTCCGCCCCCTCTG
ACGGCCAAAGACCTGTCCAGCCCGGCTGCCAGGCAGCATTGCAGTTCCCCAAGCCACGCTTCTGGCAGAGAGCCGGGGGCCAAGCCCAGC
ACTGCAGAGCCCAGCTCGAGCCCCCAGGACCCTCCCAAGCCTGTTGCTGCGCACAGTGAAAGCAGCAGCCACAAGCCCCGGCCTGGCCCT
GACCCGGGCCCTCCAAAGACTAAGCACCCCGACCGGTCCCTCTCCTCTCAGAAACCAAGTGTCGGGGCCACAAAGGGCAAAGAGCCTGCC
ACTCAGTCCCTCGGTGGCTCTAGCAGAGAGGGGAAGGGCCACAGTAAGAGTGGGCCGGATGTGTTTCCTGCTACCCCAGGCTCCCAGAAC
AAAGCCAGCGATGGGATTGGCCAGGGAGAAGGTGGGCCCTCTGTCCCACTGCACACTGACAGGGCTCCTCTAGACGCCAAGCCACAACCC
ACCAGTGGTGGGCGGCCCCTGGAGGTGCTGGAGAAGCCTGTGCATTTGCCAAGGCCGGGACACCCAGGGCCTAGTGAGCCAGCGGACCAG
AAACTGTCCGCTGTTGGTGAAAAGCAAACCCTGTCTCCAAAGCACCCCAAACCATCCACTGTGAAAGATTGCCCCACCCTGTGCAAACAG
ACAGACAACAGACAGACAGACAAAAGCCCGAGTCAGCCGGCCGCCAACACCGACAGAAGGGCGGAAGGGAAGAAATGCACTGAAGCACTT
TATGCTCCAGCAGAGGGCGACAAGCTCGAGGCCGGCCTTTCCTTTGTGCATAGCGAGAACCGGTTGAAAGGCGCGGAGCGGCCAGCCGCG
GGGGTGGGGAAGGGCTTCCCTGAGGCCAGAGGGAAAGGGCCCGGTCCCCAGAAGCCACCGACGGAGGCAGACAAGCCCAATGGCATGAAA
CGGTCCCCCTCAGCCACTGGGCAGAGTTCTTTCCGATCCACGGCCCTCCCGGAAAAGTCTCTGAGCTGCTCCTCCAGCTTCCCTGAAACC
AGGGCCGGAGTTAGAGAGGCCTCTGCAGCCAGCAGCGACACCTCTTCTGCCAAGGCCGCCGGGGGCATGCTGGAGCTTCCAGCCCCCAGC
AACAGGGACCATAGGAAGGCTCAGCCTGCCGGGGAGGGCCGAACCCACATGACAAAGAGTGACTCCCTGCCCTCCTTCCGGGTCTCCACC
CTGCCTCTGGAGTCACACCACCCCGACCCAAACACCATGGGCGGGGCCAGCCACCGGGACAGGGCTCTCTCGGTGACTGCCACCGTAGGG
GAAACCAAAGGGAAGGACCCTGCCCCAGCCCAGCCTCCCCCAGCTAGGAAACAGAACGTGGGCAGAGACGTGACCAAGCCATCCCCAGCC
CCAAACACTGACCGCCCCATCTCTCTTTCTAATGAGAAGGACTTTGTGGTACGGCAGAGGCGGGGGAAAGAGAGTTTGCGTAGCAGCCCT
CACAAAAAGGCCTTGTAACGGGGAGGGCCCAGGGGCAGGACTGTGGAGACCCGTCCTGAACGGGCGACTGTGTCTTGACTACCTTTCAAA
ACCAGCACTGTGTGGGAATGTCCGCCAGGCAGAGCTCGGAGCCTCATTGAGACAGGGGAGAGAGAAAGACAAAGAGGGGACCTTCTTCCA
GATGCCTTCCCAGTTGTAACCGGTAAAACTGTTACCAGATAGTGTTTGTACAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTACCTTTAC
AGTTGAGGGTTGTTGAGGAAAATGATTTTCTTTGTAAATATATAGCATCGTGTTTGGTTTGGGATGTAGAGTCTATACCTGGCTGCTGAT
TGCGTCGTTTACTACAGCTTTTTTTAAATAAGATTTTTGCTTTACCATTTATCATAATGTAGTAATGAAGCAAAATGGTCAAAACTGGGT
GTGTGTGAACAGAGATACACCCATATTCGTGTATATACACATCCACCTACATGTTTTGGTCTGTGGTTTAAGAGACTATTTCAAGGTTCC
ATTTTTATAAGCTAAAACATTCTAAGTTAAGATGGAAGAAAGCCCTAAACACAGTAGATTCTGAGTTTTTATGTGTATTTTAACCAGAGT
TTCTGATAGTACTGTATCTGGCTACCTATATTTCCAGATCTAAAGCAAGAACTACTCTAAGTACTGCATTTGGAATCCTCCTCCATTAGG
AATGGCCAGGACAAGTGGAGCTAGCCATTTTCATTACACGGCCATCCCAATGGACACTGGATCCCTGGTCCAACTGTCTAAAAGGCCAGT
TGTTCCTTTCTGTGGATGTGGATGTCTGGCCTTCACCTGAGGTAGAGCGGGGACTATAAACACACATCAACTTTCTTTCTGTTTGCTTTC
TTTTCCTTCTTTTCAAACTCTTAAACTCAGGCCTTTATGCTGTGAGTGACTAGTCCAAGAAGCACACATTTTGTAGTAGTCCTGCACCAG
CCCTGCTCTTGAATAAAAAGGAAAATTACTGGCTGCACCCAAATCTTCTAGTACTTGAGTAATAAGCATCAGGCATTGGAAGAGGTTTTA
AATTTGCTTTTTTGAGGAAAAGAACTGGGGGTGGATTTTGGCATCGTAGCATATCGATTAAAGAATAATCAGGACATCAGATACATTTTA
ATACATAGCTGGGGCCTTATGTTGTAGATGAAGCTTGCTGTTTTTAGCAAGTTCCTGGGTTTCACATTCATTTCTGCTGCATCTAGTAGC
TCCACACATTTCATAACCTGATCTCTTTATTTGTATGCAAAAAATACTGTCTTAATACAGAGCAGCATTTTTGTAACAAAGAGACTCGCT
GGAGCTATTTGGTGCTTGAATGTGACCATCCTTTTTACTTTTGCTAAGCCTTATTTAAATTTTGTATACCGTGGAATATGTAGAATTTGT
CAAATCATTTTAGTGCTGAAGGTTTTTGATTTCTTGTTTTTGTTTCTGTTGTTGCAGTTTCTTTGGTGGCTTGTTTTGTATTGTAAGATG
GCACTTGCTGATATAAATACTAAGGCACTAAGAGAAAATACAGATAAGTATTTATAAGTTGCTTGGGAACCATAGCAGAATTTTTTGTTT
GGTTTTGTAAGAGAAAAAAAATTACCAATAAATAACTGATCTAGCACCCAAACTCTCTTGGGGGATGTCTTAGTATCTTCACGCTATAAA
ATTGTTCATCTAAGCACAGCATCATCTTATGGCCTTATGGATTGTAAATCTTCTAGTGAGGCTATAAACTCCACTCTGAAAACAAAGGCA
TAACTTAACCGACTGCTCAGTTGTCCTTCGTTGTAAAATGAATTGGCTTTGGGAAAAAGGAAAAAAACAAACAAAAAAAGAAAAAGAAAA
AAGCCTCCTCCTTGCCCCTAATTTTTTTTTCCCATATGGTTTTAGCCATTCCCCATCACTATATTGTGAAGCTGTAAAAATATATATATA
TACTTTACAAGAGTTTACTAATGGATTTCAAAACTGGTCTCAACGTTTATAATACATATCTGTGTTTGGCAGTTGTCATAACCCAATCCT
ACATTCAGCCATCGGGACAAGTCTGTCGGGGAGGTAGTTCATGGTTTACAAGCCTTTGCTTTTTAACTGTCCAATTTCCTTTAAAGCACA
ACTAGCTATTTGTTTACAAATGATATTTTTATGTATATTTTGTATAGTGTATCATCATTTTTGCCAAATATGTTTTTCATTATAAATGAG
TAAAGAGTACTTAAGGTTGCATTCATGTATTACATGTTTGTTGTTGTAAACCTCTCCAATCAGCTGGTAGAAATTCTCCTCATTGTGTTC
TATTTGGTCAGTCTCTGTGTGATTGTAGGATGTGCTCCTTGGTAGTACTCCCAGCTGTAGATTTACCAGCTTAAAAGTTTGTTAGGATCT
GTGCAATAAAGTGTTTGCAGTCTTATTTTCTCTAAGAAATTCCTTATGGACGTCATAATTGTTGTATATTGAACAAAATATTTATACTTA

>66562_66562_6_PLXNB2-MAST4_PLXNB2_chr22_50722031_ENST00000359337_MAST4_chr5_66195779_ENST00000404260_length(amino acids)=2425AA_BP=13
MLLSAGTLLRVHPKELSLPRRGSFCRTSNRKSLIGNGQSPALPRPHSPLSAHAGNSPQDSPRNFSPSASAHFSFARSLNRTDGRRWSLAS
LPSSGYGTNTPSSTVSSSCSSQEKLHQLPYQPTPDELHFLSKHFCTTESIATENRCRNTPMRPRSRSLSPGRSPACCDHEIIMMNHVYKE
RFPKATAQMEERLKEIITSYSPDNVLPLADGVLSFTHHQIIELARDCLDKSHQGLITSRYFLELQHKLDKLLQEAHDRSESGELAFIKQL
VRKILIVIARPARLLECLEFDPEEFYYLLEAAEGHAKEGQGIKTDIPRYIISQLGLNKDPLEEMAHLGNYDSGTAETPETDESVSSSNAS
LKLRRKPRESDFETIKLISNGAYGAVYFVRHKESRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVSMYCSFETRRHLCMVME
YVEGGDCATLMKNMGPLPVDMARMYFAETVLALEYLHNYGIVHRDLKPDNLLVTSMGHIKLTDFGLSKVGLMSMTTNLYEGHIEKDAREF
LDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEINWPEKDEAPPPDAQDLITLLLRQNPLER
LGTGGAYEVKQHRFFRSLDWNSLLRQKAEFIPQLESEDDTSYFDTRSEKYHHMETEEEDDTNDEDFNVEIRQFSSCSHRFSKVFSSIDRI
TQNSAEEKEDSVDKTKSTTLPSTETLSWSSEYSEMQQLSTSNSSDTESNRHKLSSGLLPKLAISTEGEQDEAASCPGDPHEEPGKPALPP
EECAQEEPEVTTPASTISSSTLSVGSFSEHLDQINGRSECVDSTDNSSKPSSEPASHMARQRLESTEKKKISGKVTKSLSASALSLMIPG
DMFAVSPLGSPMSPHSLSSDPSSSRDSSPSRDSSAASASPHQPIVIHSSGKNYGFTIRAIRVYVGDSDIYTVHHIVWNVEEGSPACQAGL
KAGDLITHINGEPVHGLVHTEVIELLLKSGNKVSITTTPFENTSIKTGPARRNSYKSRMVRRSKKSKKKESLERRRSLFKKLAKQPSPLL
HTSRSFSCLNRSLSSGESLPGSPTHSLSPRSPTPSYRSTPDFPSGTNSSQSSSPSSSAPNSPAGSGHIRPSTLHGLAPKLGGQRYRSGRR
KSAGNIPLSPLARTPSPTPQPTSPQRSPSPLLGHSLGNSKIAQAFPSKMHSPPTIVRHIVRPKSAEPPRSPLLKRVQSEEKLSPSYGSDK
KHLCSRKHSLEVTQEEVQREQSQREAPLQSLDENVCDVPPLSRARPVEQGCLKRPVSRKVGRQESVDDLDRDKLKAKVVVKKADGFPEKQ
ESHQKSHGPGSDLENFALFKLEEREKKVYPKAVERSSTFENKASMQEAPPLGSLLKDALHKQASVRASEGAMSDGRVPAEHRQGGGDFRR
APAPGTLQDGLCHSLDRGISGKGEGTEKSSQAKELLRCEKLDSKLANIDYLRKKMSLEDKEDNLCPVLKPKMTAGSHECLPGNPVRPTGG
QQEPPPASESRAFVSSTHAAQMSAVSFVPLKALTGRVDSGTEKPGLVAPESPVRKSPSEYKLEGRSVSCLKPIEGTLDIALLSGPQASKT
ELPSPESAQSPSPSGDVRASVPPVLPSSSGKKNDTTSARELSPSSLKMNKSYLLEPWFLPPSRGLQNSPAVSLPDPEFKRDRKGPHPTAR
SPGTVMESNPQQREGSSPKHQDHTTDPKLLTCLGQNLHSPDLARPRCPLPPEASPSREKPGLRESSERGPPTARSERSAARADTCREPSM
ELCFPETAKTSDNSKNLLSVGRTHPDFYTQTQAMEKAWAPGGKTNHKDGPGEARPPPRDNSSLHSAGIPCEKELGKVRRGVEPKPEALLA
RRSLQPPGIESEKSEKLSSFPSLQKDGAKEPERKEQPLQRHPSSIPPPPLTAKDLSSPAARQHCSSPSHASGREPGAKPSTAEPSSSPQD
PPKPVAAHSESSSHKPRPGPDPGPPKTKHPDRSLSSQKPSVGATKGKEPATQSLGGSSREGKGHSKSGPDVFPATPGSQNKASDGIGQGE
GGPSVPLHTDRAPLDAKPQPTSGGRPLEVLEKPVHLPRPGHPGPSEPADQKLSAVGEKQTLSPKHPKPSTVKDCPTLCKQTDNRQTDKSP
SQPAANTDRRAEGKKCTEALYAPAEGDKLEAGLSFVHSENRLKGAERPAAGVGKGFPEARGKGPGPQKPPTEADKPNGMKRSPSATGQSS
FRSTALPEKSLSCSSSFPETRAGVREASAASSDTSSAKAAGGMLELPAPSNRDHRKAQPAGEGRTHMTKSDSLPSFRVSTLPLESHHPDP

--------------------------------------------------------------
>66562_66562_7_PLXNB2-MAST4_PLXNB2_chr22_50722031_ENST00000359337_MAST4_chr5_66195779_ENST00000406039_length(transcript)=2754nt_BP=2679nt
CCCGGGCGCCATCGAGCCTTGGCGGCGGACGTGCAGAGAATCTCGATGCTGGCCTGGAGCAGAAACTGAGCTGGACCACTGGAGCCTCGG
TGAGGGGGTGCGGGGGGCAATGGCACTGCAGCTCTGGGCCCTGACCCTGCTGGGCCTGCTGGGCGCAGGTGCCAGCCTGAGGCCCCGCAA
GCTGGACTTCTTCCGCAGCGAGAAAGAGCTGAACCACCTGGCTGTGGATGAGGCCTCAGGCGTGGTGTACCTGGGGGCGGTGAATGCCCT
CTACCAGCTGGATGCGAAGCTGCAGCTGGAGCAGCAGGTGGCCACGGGCCCGGCCCTGGACAACAAGAAGTGCACGCCGCCCATCGAGGC
CAGCCAGTGCCATGAGGCTGAGATGACTGACAATGTCAACCAGCTGCTGCTGCTCGACCCTCCCAGGAAGCGCCTGGTGGAGTGCGGCAG
CCTCTTCAAGGGCATCTGCGCTCTGCGCGCCCTGAGCAACATCTCCCTCCGCCTGTTCTACGAGGACGGCAGCGGGGAGAAGTCTTTCGT
GGCCAGCAATGATGAGGGCGTGGCCACAGTGGGGCTGGTGAGCTCCACGGGTCCTGGTGGTGACCGCGTGCTGTTTGTGGGCAAAGGCAA
TGGGCCACACGACAACGGCATCATCGTGAGCACTCGGCTGTTGGACCGGACTGACAGCAGGGAGGCCTTTGAAGCCTACACGGACCACGC
CACCTACAAGGCCGGCTACCTGTCCACCAACACACAGCAGTTCGTGGCGGCCTTCGAGGACGGCCCCTACGTCTTCTTTGTCTTCAACCA
GCAGGACAAGCACCCGGCCCGGAACCGCACGCTGCTGGCACGCATGTGCAGAGAAGACCCCAACTACTACTCCTACCTGGAGATGGACCT
GCAGTGCCGGGACCCCGACATCCACGCCGCTGCCTTTGGCACCTGCCTGGCCGCCTCCGTGGCTGCGCCTGGCTCTGGCAGGGTGCTATA
TGCTGTCTTCAGCAGAGACAGCCGGAGCAGTGGGGGGCCCGGTGCGGGCCTCTGCCTGTTCCCGCTGGACAAGGTGCACGCCAAGATGGA
GGCCAACCGCAACGCCTGTTACACAGGCACCCGGGAGGCCCGTGACATCTTCTACAAGCCCTTCCACGGCGATATCCAGTGCGGCGGCCA
CGCGCCGGGCTCCAGCAAGAGCTTCCCATGTGGCTCGGAGCACCTGCCCTACCCGCTGGGCAGCCGCGACGGGCTCAGAGGCACAGCCGT
GCTGCAGCGTGGAGGCCTGAACCTCACGGCCGTGACGGTCGCCGCCGAGAACAACCACACTGTTGCTTTTCTGGGCACCTCTGATGGCCG
GATCCTCAAGGTGTACCTCACCCCAGATGGCACCTCCTCAGAGTACGACTCTATCCTTGTGGAGATAAACAAGAGAGTCAAGCGCGACCT
GGTACTGTCTGGAGACCTGGGCAGCCTGTACGCCATGACCCAGGACAAGGTGTTCCGGCTGCCGGTGCAGGAGTGCCTGAGCTACCCGAC
CTGCACCCAGTGCCGCGACTCCCAGGACCCCTACTGCGGCTGGTGCGTCGTCGAGGGACGATGCACCCGGAAGGCCGAGTGTCCGCGGGC
CGAGGAGGCCAGCCACTGGCTGTGGAGCCGAAGCAAGTCCTGCGTGGCCGTCACCAGCGCCCAGCCACAGAACATGAGCCGGCGGGCCCA
GGGGGAGGTGCAGCTGACCGTCAGCCCCCTCCCTGCCCTGAGCGAGGAGGACGAGTTGCTGTGCCTTTTTGGGGAGTCGCCGCCACACCC
CGCCCGCGTGGAGGGCGAGGCCGTCATCTGCAACTCCCCAAGCAGCATCCCCGTCACACCGCCAGGCCAGGACCACGTGGCCGTGACCAT
CCAGCTCCTCCTTAGACGAGGCAACATCTTCCTCACGTCCTACCAGTACCCCTTCTACGACTGCCGCCAGGCCATGAGCCTGGAGGAGAA
CCTGCCGTGCATCTCCTGCGTGAGCAACCGCTGGACCTGCCAGTGGGACCTGCGCTACCACGAGTGCCGGGAGGCTTCGCCCAACCCTGA
GGACGGCATCGTCCGTGCCCACATGGAGGACAGCTGTCCCCAGTTCCTGGGACCCAGCCCCCTGGTGATCCCCATGAACCACGAGACAGA
TGTGAACTTCCAGGGCAAGAACCTGGACACCGTGAAGGGTTCCTCCCTGCACGTGGGCAGTGACTTGCTCAAGTTCATGGAGCCGGTGAC
CATGCAGGAATCTGGGACCTTCGCCTTTCGGACCCCAAAGCTGTCCCACGATGCCAACGAGACGCTGCCCCTGCACCTCTACGTCAAGTC
TTACGGCAAGAATATCGACAGCAAGCTCCATGTGACCCTCTACAACTGCTCCTTTGGCCGCAGCGACTGCAGCCTGTGCCGGGCCGCTAA
CCCCGACTACAGGTGTGCGTGGTGCGGGGGCCAGAGCAGGTGCGTGTATGAGGCCCTGTGCAACACCACCTCCGAGTGCCCGCCGCCCGT
CATCACCAGGATCCAGCCTGAGACGGGCCCCCTGGGTGGGGGCATCCGCATCACCATCCTGGGGTCCAATTTGGGCGTCCAAGCAGGGGA
CATCCAGAGGATCTCTGTGGCCGGCCGGAACTGCTCCTTTCAGCCGGAACGTTACTCCGTGTCCACCCGAAGGAGCTGAGTCTCCCCAGA

>66562_66562_7_PLXNB2-MAST4_PLXNB2_chr22_50722031_ENST00000359337_MAST4_chr5_66195779_ENST00000406039_length(amino acids)=872AA_BP=
MDHWSLGEGVRGAMALQLWALTLLGLLGAGASLRPRKLDFFRSEKELNHLAVDEASGVVYLGAVNALYQLDAKLQLEQQVATGPALDNKK
CTPPIEASQCHEAEMTDNVNQLLLLDPPRKRLVECGSLFKGICALRALSNISLRLFYEDGSGEKSFVASNDEGVATVGLVSSTGPGGDRV
LFVGKGNGPHDNGIIVSTRLLDRTDSREAFEAYTDHATYKAGYLSTNTQQFVAAFEDGPYVFFVFNQQDKHPARNRTLLARMCREDPNYY
SYLEMDLQCRDPDIHAAAFGTCLAASVAAPGSGRVLYAVFSRDSRSSGGPGAGLCLFPLDKVHAKMEANRNACYTGTREARDIFYKPFHG
DIQCGGHAPGSSKSFPCGSEHLPYPLGSRDGLRGTAVLQRGGLNLTAVTVAAENNHTVAFLGTSDGRILKVYLTPDGTSSEYDSILVEIN
KRVKRDLVLSGDLGSLYAMTQDKVFRLPVQECLSYPTCTQCRDSQDPYCGWCVVEGRCTRKAECPRAEEASHWLWSRSKSCVAVTSAQPQ
NMSRRAQGEVQLTVSPLPALSEEDELLCLFGESPPHPARVEGEAVICNSPSSIPVTPPGQDHVAVTIQLLLRRGNIFLTSYQYPFYDCRQ
AMSLEENLPCISCVSNRWTCQWDLRYHECREASPNPEDGIVRAHMEDSCPQFLGPSPLVIPMNHETDVNFQGKNLDTVKGSSLHVGSDLL
KFMEPVTMQESGTFAFRTPKLSHDANETLPLHLYVKSYGKNIDSKLHVTLYNCSFGRSDCSLCRAANPDYRCAWCGGQSRCVYEALCNTT

--------------------------------------------------------------
>66562_66562_8_PLXNB2-MAST4_PLXNB2_chr22_50722031_ENST00000359337_MAST4_chr5_66195779_ENST00000406374_length(transcript)=2827nt_BP=2679nt
CCCGGGCGCCATCGAGCCTTGGCGGCGGACGTGCAGAGAATCTCGATGCTGGCCTGGAGCAGAAACTGAGCTGGACCACTGGAGCCTCGG
TGAGGGGGTGCGGGGGGCAATGGCACTGCAGCTCTGGGCCCTGACCCTGCTGGGCCTGCTGGGCGCAGGTGCCAGCCTGAGGCCCCGCAA
GCTGGACTTCTTCCGCAGCGAGAAAGAGCTGAACCACCTGGCTGTGGATGAGGCCTCAGGCGTGGTGTACCTGGGGGCGGTGAATGCCCT
CTACCAGCTGGATGCGAAGCTGCAGCTGGAGCAGCAGGTGGCCACGGGCCCGGCCCTGGACAACAAGAAGTGCACGCCGCCCATCGAGGC
CAGCCAGTGCCATGAGGCTGAGATGACTGACAATGTCAACCAGCTGCTGCTGCTCGACCCTCCCAGGAAGCGCCTGGTGGAGTGCGGCAG
CCTCTTCAAGGGCATCTGCGCTCTGCGCGCCCTGAGCAACATCTCCCTCCGCCTGTTCTACGAGGACGGCAGCGGGGAGAAGTCTTTCGT
GGCCAGCAATGATGAGGGCGTGGCCACAGTGGGGCTGGTGAGCTCCACGGGTCCTGGTGGTGACCGCGTGCTGTTTGTGGGCAAAGGCAA
TGGGCCACACGACAACGGCATCATCGTGAGCACTCGGCTGTTGGACCGGACTGACAGCAGGGAGGCCTTTGAAGCCTACACGGACCACGC
CACCTACAAGGCCGGCTACCTGTCCACCAACACACAGCAGTTCGTGGCGGCCTTCGAGGACGGCCCCTACGTCTTCTTTGTCTTCAACCA
GCAGGACAAGCACCCGGCCCGGAACCGCACGCTGCTGGCACGCATGTGCAGAGAAGACCCCAACTACTACTCCTACCTGGAGATGGACCT
GCAGTGCCGGGACCCCGACATCCACGCCGCTGCCTTTGGCACCTGCCTGGCCGCCTCCGTGGCTGCGCCTGGCTCTGGCAGGGTGCTATA
TGCTGTCTTCAGCAGAGACAGCCGGAGCAGTGGGGGGCCCGGTGCGGGCCTCTGCCTGTTCCCGCTGGACAAGGTGCACGCCAAGATGGA
GGCCAACCGCAACGCCTGTTACACAGGCACCCGGGAGGCCCGTGACATCTTCTACAAGCCCTTCCACGGCGATATCCAGTGCGGCGGCCA
CGCGCCGGGCTCCAGCAAGAGCTTCCCATGTGGCTCGGAGCACCTGCCCTACCCGCTGGGCAGCCGCGACGGGCTCAGAGGCACAGCCGT
GCTGCAGCGTGGAGGCCTGAACCTCACGGCCGTGACGGTCGCCGCCGAGAACAACCACACTGTTGCTTTTCTGGGCACCTCTGATGGCCG
GATCCTCAAGGTGTACCTCACCCCAGATGGCACCTCCTCAGAGTACGACTCTATCCTTGTGGAGATAAACAAGAGAGTCAAGCGCGACCT
GGTACTGTCTGGAGACCTGGGCAGCCTGTACGCCATGACCCAGGACAAGGTGTTCCGGCTGCCGGTGCAGGAGTGCCTGAGCTACCCGAC
CTGCACCCAGTGCCGCGACTCCCAGGACCCCTACTGCGGCTGGTGCGTCGTCGAGGGACGATGCACCCGGAAGGCCGAGTGTCCGCGGGC
CGAGGAGGCCAGCCACTGGCTGTGGAGCCGAAGCAAGTCCTGCGTGGCCGTCACCAGCGCCCAGCCACAGAACATGAGCCGGCGGGCCCA
GGGGGAGGTGCAGCTGACCGTCAGCCCCCTCCCTGCCCTGAGCGAGGAGGACGAGTTGCTGTGCCTTTTTGGGGAGTCGCCGCCACACCC
CGCCCGCGTGGAGGGCGAGGCCGTCATCTGCAACTCCCCAAGCAGCATCCCCGTCACACCGCCAGGCCAGGACCACGTGGCCGTGACCAT
CCAGCTCCTCCTTAGACGAGGCAACATCTTCCTCACGTCCTACCAGTACCCCTTCTACGACTGCCGCCAGGCCATGAGCCTGGAGGAGAA
CCTGCCGTGCATCTCCTGCGTGAGCAACCGCTGGACCTGCCAGTGGGACCTGCGCTACCACGAGTGCCGGGAGGCTTCGCCCAACCCTGA
GGACGGCATCGTCCGTGCCCACATGGAGGACAGCTGTCCCCAGTTCCTGGGACCCAGCCCCCTGGTGATCCCCATGAACCACGAGACAGA
TGTGAACTTCCAGGGCAAGAACCTGGACACCGTGAAGGGTTCCTCCCTGCACGTGGGCAGTGACTTGCTCAAGTTCATGGAGCCGGTGAC
CATGCAGGAATCTGGGACCTTCGCCTTTCGGACCCCAAAGCTGTCCCACGATGCCAACGAGACGCTGCCCCTGCACCTCTACGTCAAGTC
TTACGGCAAGAATATCGACAGCAAGCTCCATGTGACCCTCTACAACTGCTCCTTTGGCCGCAGCGACTGCAGCCTGTGCCGGGCCGCTAA
CCCCGACTACAGGTGTGCGTGGTGCGGGGGCCAGAGCAGGTGCGTGTATGAGGCCCTGTGCAACACCACCTCCGAGTGCCCGCCGCCCGT
CATCACCAGGATCCAGCCTGAGACGGGCCCCCTGGGTGGGGGCATCCGCATCACCATCCTGGGGTCCAATTTGGGCGTCCAAGCAGGGGA
CATCCAGAGGATCTCTGTGGCCGGCCGGAACTGCTCCTTTCAGCCGGAACGTTACTCCGTGTCCACCCGAAGGAGCTGAGTCTCCCCAGA
AGAGGAAGTTTGATAGATTCCCAGAAGTGGAATTGCTTGGTCAAACGCCCTGTGTGTCCAAATGCTGGGAGAACATCACCCCTTGGATGA

>66562_66562_8_PLXNB2-MAST4_PLXNB2_chr22_50722031_ENST00000359337_MAST4_chr5_66195779_ENST00000406374_length(amino acids)=872AA_BP=
MDHWSLGEGVRGAMALQLWALTLLGLLGAGASLRPRKLDFFRSEKELNHLAVDEASGVVYLGAVNALYQLDAKLQLEQQVATGPALDNKK
CTPPIEASQCHEAEMTDNVNQLLLLDPPRKRLVECGSLFKGICALRALSNISLRLFYEDGSGEKSFVASNDEGVATVGLVSSTGPGGDRV
LFVGKGNGPHDNGIIVSTRLLDRTDSREAFEAYTDHATYKAGYLSTNTQQFVAAFEDGPYVFFVFNQQDKHPARNRTLLARMCREDPNYY
SYLEMDLQCRDPDIHAAAFGTCLAASVAAPGSGRVLYAVFSRDSRSSGGPGAGLCLFPLDKVHAKMEANRNACYTGTREARDIFYKPFHG
DIQCGGHAPGSSKSFPCGSEHLPYPLGSRDGLRGTAVLQRGGLNLTAVTVAAENNHTVAFLGTSDGRILKVYLTPDGTSSEYDSILVEIN
KRVKRDLVLSGDLGSLYAMTQDKVFRLPVQECLSYPTCTQCRDSQDPYCGWCVVEGRCTRKAECPRAEEASHWLWSRSKSCVAVTSAQPQ
NMSRRAQGEVQLTVSPLPALSEEDELLCLFGESPPHPARVEGEAVICNSPSSIPVTPPGQDHVAVTIQLLLRRGNIFLTSYQYPFYDCRQ
AMSLEENLPCISCVSNRWTCQWDLRYHECREASPNPEDGIVRAHMEDSCPQFLGPSPLVIPMNHETDVNFQGKNLDTVKGSSLHVGSDLL
KFMEPVTMQESGTFAFRTPKLSHDANETLPLHLYVKSYGKNIDSKLHVTLYNCSFGRSDCSLCRAANPDYRCAWCGGQSRCVYEALCNTT

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PLXNB2-MAST4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PLXNB2-MAST4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PLXNB2-MAST4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource