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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PLXNC1-TXNRD1 (FusionGDB2 ID:66588)

Fusion Gene Summary for PLXNC1-TXNRD1

check button Fusion gene summary
Fusion gene informationFusion gene name: PLXNC1-TXNRD1
Fusion gene ID: 66588
HgeneTgene
Gene symbol

PLXNC1

TXNRD1

Gene ID

10154

7296

Gene nameplexin C1thioredoxin reductase 1
SynonymsCD232|PLXN-C1|VESPRGRIM-12|TR|TR1|TRXR1|TXNR
Cytomap

12q22

12q23.3

Type of geneprotein-codingprotein-coding
Descriptionplexin-C1plexin (semaphorin receptor)receptor for viral semaphorin proteinreceptor for virally-encoded semaphorinvirus-encoded semaphorin protein receptorthioredoxin reductase 1, cytoplasmicKM-102-derived reductase-like factorgene associated with retinoic and IFN-induced mortality 12 proteingene associated with retinoic and interferon-induced mortality 12 proteinoxidoreductasetestis tissue sperm-bindi
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000258526, ENST00000545312, 
ENST00000547057, ENST00000551495, 
ENST00000378070, ENST00000397736, 
ENST00000427956, ENST00000526950, 
ENST00000526006, ENST00000354940, 
ENST00000388854, ENST00000429002, 
ENST00000503506, ENST00000524698, 
ENST00000525566, ENST00000526390, 
ENST00000526691, ENST00000529546, 
ENST00000542918, ENST00000540716, 
Fusion gene scores* DoF score7 X 6 X 5=21011 X 11 X 4=484
# samples 1012
** MAII scorelog2(10/210*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/484*10)=-2.01197264166608
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PLXNC1 [Title/Abstract] AND TXNRD1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPLXNC1(94676177)-TXNRD1(104742131), # samples:3
Anticipated loss of major functional domain due to fusion event.PLXNC1-TXNRD1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PLXNC1-TXNRD1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
PLXNC1-TXNRD1 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PLXNC1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TXNRD1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A3U5-01APLXNC1chr12

94676177

-TXNRD1chr12

104742131

+
ChimerDB4SARCTCGA-DX-A3U5-01APLXNC1chr12

94676177

+TXNRD1chr12

104742131

+
ChimerDB4SARCTCGA-DX-A3U5PLXNC1chr12

94676177

+TXNRD1chr12

104742130

+


Top

Fusion Gene ORF analysis for PLXNC1-TXNRD1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000258526ENST00000378070PLXNC1chr12

94676177

+TXNRD1chr12

104742131

+
5CDS-3UTRENST00000258526ENST00000378070PLXNC1chr12

94676177

+TXNRD1chr12

104742130

+
5CDS-3UTRENST00000258526ENST00000397736PLXNC1chr12

94676177

+TXNRD1chr12

104742131

+
5CDS-3UTRENST00000258526ENST00000397736PLXNC1chr12

94676177

+TXNRD1chr12

104742130

+
5CDS-3UTRENST00000258526ENST00000427956PLXNC1chr12

94676177

+TXNRD1chr12

104742131

+
5CDS-3UTRENST00000258526ENST00000427956PLXNC1chr12

94676177

+TXNRD1chr12

104742130

+
5CDS-3UTRENST00000258526ENST00000526950PLXNC1chr12

94676177

+TXNRD1chr12

104742131

+
5CDS-3UTRENST00000258526ENST00000526950PLXNC1chr12

94676177

+TXNRD1chr12

104742130

+
5CDS-3UTRENST00000545312ENST00000378070PLXNC1chr12

94676177

+TXNRD1chr12

104742131

+
5CDS-3UTRENST00000545312ENST00000378070PLXNC1chr12

94676177

+TXNRD1chr12

104742130

+
5CDS-3UTRENST00000545312ENST00000397736PLXNC1chr12

94676177

+TXNRD1chr12

104742131

+
5CDS-3UTRENST00000545312ENST00000397736PLXNC1chr12

94676177

+TXNRD1chr12

104742130

+
5CDS-3UTRENST00000545312ENST00000427956PLXNC1chr12

94676177

+TXNRD1chr12

104742131

+
5CDS-3UTRENST00000545312ENST00000427956PLXNC1chr12

94676177

+TXNRD1chr12

104742130

+
5CDS-3UTRENST00000545312ENST00000526950PLXNC1chr12

94676177

+TXNRD1chr12

104742131

+
5CDS-3UTRENST00000545312ENST00000526950PLXNC1chr12

94676177

+TXNRD1chr12

104742130

+
5CDS-3UTRENST00000547057ENST00000378070PLXNC1chr12

94676177

+TXNRD1chr12

104742131

+
5CDS-3UTRENST00000547057ENST00000378070PLXNC1chr12

94676177

+TXNRD1chr12

104742130

+
5CDS-3UTRENST00000547057ENST00000397736PLXNC1chr12

94676177

+TXNRD1chr12

104742131

+
5CDS-3UTRENST00000547057ENST00000397736PLXNC1chr12

94676177

+TXNRD1chr12

104742130

+
5CDS-3UTRENST00000547057ENST00000427956PLXNC1chr12

94676177

+TXNRD1chr12

104742131

+
5CDS-3UTRENST00000547057ENST00000427956PLXNC1chr12

94676177

+TXNRD1chr12

104742130

+
5CDS-3UTRENST00000547057ENST00000526950PLXNC1chr12

94676177

+TXNRD1chr12

104742131

+
5CDS-3UTRENST00000547057ENST00000526950PLXNC1chr12

94676177

+TXNRD1chr12

104742130

+
5CDS-intronENST00000258526ENST00000526006PLXNC1chr12

94676177

+TXNRD1chr12

104742131

+
5CDS-intronENST00000258526ENST00000526006PLXNC1chr12

94676177

+TXNRD1chr12

104742130

+
5CDS-intronENST00000545312ENST00000526006PLXNC1chr12

94676177

+TXNRD1chr12

104742131

+
5CDS-intronENST00000545312ENST00000526006PLXNC1chr12

94676177

+TXNRD1chr12

104742130

+
5CDS-intronENST00000547057ENST00000526006PLXNC1chr12

94676177

+TXNRD1chr12

104742131

+
5CDS-intronENST00000547057ENST00000526006PLXNC1chr12

94676177

+TXNRD1chr12

104742130

+
Frame-shiftENST00000258526ENST00000354940PLXNC1chr12

94676177

+TXNRD1chr12

104742131

+
Frame-shiftENST00000258526ENST00000354940PLXNC1chr12

94676177

+TXNRD1chr12

104742130

+
Frame-shiftENST00000258526ENST00000388854PLXNC1chr12

94676177

+TXNRD1chr12

104742131

+
Frame-shiftENST00000258526ENST00000388854PLXNC1chr12

94676177

+TXNRD1chr12

104742130

+
Frame-shiftENST00000258526ENST00000429002PLXNC1chr12

94676177

+TXNRD1chr12

104742131

+
Frame-shiftENST00000258526ENST00000429002PLXNC1chr12

94676177

+TXNRD1chr12

104742130

+
Frame-shiftENST00000258526ENST00000503506PLXNC1chr12

94676177

+TXNRD1chr12

104742131

+
Frame-shiftENST00000258526ENST00000503506PLXNC1chr12

94676177

+TXNRD1chr12

104742130

+
Frame-shiftENST00000258526ENST00000524698PLXNC1chr12

94676177

+TXNRD1chr12

104742131

+
Frame-shiftENST00000258526ENST00000524698PLXNC1chr12

94676177

+TXNRD1chr12

104742130

+
Frame-shiftENST00000258526ENST00000525566PLXNC1chr12

94676177

+TXNRD1chr12

104742131

+
Frame-shiftENST00000258526ENST00000525566PLXNC1chr12

94676177

+TXNRD1chr12

104742130

+
Frame-shiftENST00000258526ENST00000526390PLXNC1chr12

94676177

+TXNRD1chr12

104742131

+
Frame-shiftENST00000258526ENST00000526390PLXNC1chr12

94676177

+TXNRD1chr12

104742130

+
Frame-shiftENST00000258526ENST00000526691PLXNC1chr12

94676177

+TXNRD1chr12

104742131

+
Frame-shiftENST00000258526ENST00000526691PLXNC1chr12

94676177

+TXNRD1chr12

104742130

+
Frame-shiftENST00000258526ENST00000529546PLXNC1chr12

94676177

+TXNRD1chr12

104742131

+
Frame-shiftENST00000258526ENST00000529546PLXNC1chr12

94676177

+TXNRD1chr12

104742130

+
Frame-shiftENST00000258526ENST00000542918PLXNC1chr12

94676177

+TXNRD1chr12

104742131

+
Frame-shiftENST00000258526ENST00000542918PLXNC1chr12

94676177

+TXNRD1chr12

104742130

+
Frame-shiftENST00000545312ENST00000354940PLXNC1chr12

94676177

+TXNRD1chr12

104742131

+
Frame-shiftENST00000545312ENST00000354940PLXNC1chr12

94676177

+TXNRD1chr12

104742130

+
Frame-shiftENST00000545312ENST00000388854PLXNC1chr12

94676177

+TXNRD1chr12

104742131

+
Frame-shiftENST00000545312ENST00000388854PLXNC1chr12

94676177

+TXNRD1chr12

104742130

+
Frame-shiftENST00000545312ENST00000429002PLXNC1chr12

94676177

+TXNRD1chr12

104742131

+
Frame-shiftENST00000545312ENST00000429002PLXNC1chr12

94676177

+TXNRD1chr12

104742130

+
Frame-shiftENST00000545312ENST00000503506PLXNC1chr12

94676177

+TXNRD1chr12

104742131

+
Frame-shiftENST00000545312ENST00000503506PLXNC1chr12

94676177

+TXNRD1chr12

104742130

+
Frame-shiftENST00000545312ENST00000524698PLXNC1chr12

94676177

+TXNRD1chr12

104742131

+
Frame-shiftENST00000545312ENST00000524698PLXNC1chr12

94676177

+TXNRD1chr12

104742130

+
Frame-shiftENST00000545312ENST00000525566PLXNC1chr12

94676177

+TXNRD1chr12

104742131

+
Frame-shiftENST00000545312ENST00000525566PLXNC1chr12

94676177

+TXNRD1chr12

104742130

+
Frame-shiftENST00000545312ENST00000526390PLXNC1chr12

94676177

+TXNRD1chr12

104742131

+
Frame-shiftENST00000545312ENST00000526390PLXNC1chr12

94676177

+TXNRD1chr12

104742130

+
Frame-shiftENST00000545312ENST00000526691PLXNC1chr12

94676177

+TXNRD1chr12

104742131

+
Frame-shiftENST00000545312ENST00000526691PLXNC1chr12

94676177

+TXNRD1chr12

104742130

+
Frame-shiftENST00000545312ENST00000529546PLXNC1chr12

94676177

+TXNRD1chr12

104742131

+
Frame-shiftENST00000545312ENST00000529546PLXNC1chr12

94676177

+TXNRD1chr12

104742130

+
Frame-shiftENST00000545312ENST00000542918PLXNC1chr12

94676177

+TXNRD1chr12

104742131

+
Frame-shiftENST00000545312ENST00000542918PLXNC1chr12

94676177

+TXNRD1chr12

104742130

+
Frame-shiftENST00000547057ENST00000354940PLXNC1chr12

94676177

+TXNRD1chr12

104742131

+
Frame-shiftENST00000547057ENST00000354940PLXNC1chr12

94676177

+TXNRD1chr12

104742130

+
Frame-shiftENST00000547057ENST00000388854PLXNC1chr12

94676177

+TXNRD1chr12

104742131

+
Frame-shiftENST00000547057ENST00000388854PLXNC1chr12

94676177

+TXNRD1chr12

104742130

+
Frame-shiftENST00000547057ENST00000429002PLXNC1chr12

94676177

+TXNRD1chr12

104742131

+
Frame-shiftENST00000547057ENST00000429002PLXNC1chr12

94676177

+TXNRD1chr12

104742130

+
Frame-shiftENST00000547057ENST00000503506PLXNC1chr12

94676177

+TXNRD1chr12

104742131

+
Frame-shiftENST00000547057ENST00000503506PLXNC1chr12

94676177

+TXNRD1chr12

104742130

+
Frame-shiftENST00000547057ENST00000524698PLXNC1chr12

94676177

+TXNRD1chr12

104742131

+
Frame-shiftENST00000547057ENST00000524698PLXNC1chr12

94676177

+TXNRD1chr12

104742130

+
Frame-shiftENST00000547057ENST00000525566PLXNC1chr12

94676177

+TXNRD1chr12

104742131

+
Frame-shiftENST00000547057ENST00000525566PLXNC1chr12

94676177

+TXNRD1chr12

104742130

+
Frame-shiftENST00000547057ENST00000526390PLXNC1chr12

94676177

+TXNRD1chr12

104742131

+
Frame-shiftENST00000547057ENST00000526390PLXNC1chr12

94676177

+TXNRD1chr12

104742130

+
Frame-shiftENST00000547057ENST00000526691PLXNC1chr12

94676177

+TXNRD1chr12

104742131

+
Frame-shiftENST00000547057ENST00000526691PLXNC1chr12

94676177

+TXNRD1chr12

104742130

+
Frame-shiftENST00000547057ENST00000529546PLXNC1chr12

94676177

+TXNRD1chr12

104742131

+
Frame-shiftENST00000547057ENST00000529546PLXNC1chr12

94676177

+TXNRD1chr12

104742130

+
Frame-shiftENST00000547057ENST00000542918PLXNC1chr12

94676177

+TXNRD1chr12

104742131

+
Frame-shiftENST00000547057ENST00000542918PLXNC1chr12

94676177

+TXNRD1chr12

104742130

+
In-frameENST00000258526ENST00000540716PLXNC1chr12

94676177

+TXNRD1chr12

104742131

+
In-frameENST00000258526ENST00000540716PLXNC1chr12

94676177

+TXNRD1chr12

104742130

+
In-frameENST00000545312ENST00000540716PLXNC1chr12

94676177

+TXNRD1chr12

104742131

+
In-frameENST00000545312ENST00000540716PLXNC1chr12

94676177

+TXNRD1chr12

104742130

+
In-frameENST00000547057ENST00000540716PLXNC1chr12

94676177

+TXNRD1chr12

104742131

+
In-frameENST00000547057ENST00000540716PLXNC1chr12

94676177

+TXNRD1chr12

104742130

+
intron-3CDSENST00000551495ENST00000354940PLXNC1chr12

94676177

+TXNRD1chr12

104742131

+
intron-3CDSENST00000551495ENST00000354940PLXNC1chr12

94676177

+TXNRD1chr12

104742130

+
intron-3CDSENST00000551495ENST00000388854PLXNC1chr12

94676177

+TXNRD1chr12

104742131

+
intron-3CDSENST00000551495ENST00000388854PLXNC1chr12

94676177

+TXNRD1chr12

104742130

+
intron-3CDSENST00000551495ENST00000429002PLXNC1chr12

94676177

+TXNRD1chr12

104742131

+
intron-3CDSENST00000551495ENST00000429002PLXNC1chr12

94676177

+TXNRD1chr12

104742130

+
intron-3CDSENST00000551495ENST00000503506PLXNC1chr12

94676177

+TXNRD1chr12

104742131

+
intron-3CDSENST00000551495ENST00000503506PLXNC1chr12

94676177

+TXNRD1chr12

104742130

+
intron-3CDSENST00000551495ENST00000524698PLXNC1chr12

94676177

+TXNRD1chr12

104742131

+
intron-3CDSENST00000551495ENST00000524698PLXNC1chr12

94676177

+TXNRD1chr12

104742130

+
intron-3CDSENST00000551495ENST00000525566PLXNC1chr12

94676177

+TXNRD1chr12

104742131

+
intron-3CDSENST00000551495ENST00000525566PLXNC1chr12

94676177

+TXNRD1chr12

104742130

+
intron-3CDSENST00000551495ENST00000526390PLXNC1chr12

94676177

+TXNRD1chr12

104742131

+
intron-3CDSENST00000551495ENST00000526390PLXNC1chr12

94676177

+TXNRD1chr12

104742130

+
intron-3CDSENST00000551495ENST00000526691PLXNC1chr12

94676177

+TXNRD1chr12

104742131

+
intron-3CDSENST00000551495ENST00000526691PLXNC1chr12

94676177

+TXNRD1chr12

104742130

+
intron-3CDSENST00000551495ENST00000529546PLXNC1chr12

94676177

+TXNRD1chr12

104742131

+
intron-3CDSENST00000551495ENST00000529546PLXNC1chr12

94676177

+TXNRD1chr12

104742130

+
intron-3CDSENST00000551495ENST00000540716PLXNC1chr12

94676177

+TXNRD1chr12

104742131

+
intron-3CDSENST00000551495ENST00000540716PLXNC1chr12

94676177

+TXNRD1chr12

104742130

+
intron-3CDSENST00000551495ENST00000542918PLXNC1chr12

94676177

+TXNRD1chr12

104742131

+
intron-3CDSENST00000551495ENST00000542918PLXNC1chr12

94676177

+TXNRD1chr12

104742130

+
intron-3UTRENST00000551495ENST00000378070PLXNC1chr12

94676177

+TXNRD1chr12

104742131

+
intron-3UTRENST00000551495ENST00000378070PLXNC1chr12

94676177

+TXNRD1chr12

104742130

+
intron-3UTRENST00000551495ENST00000397736PLXNC1chr12

94676177

+TXNRD1chr12

104742131

+
intron-3UTRENST00000551495ENST00000397736PLXNC1chr12

94676177

+TXNRD1chr12

104742130

+
intron-3UTRENST00000551495ENST00000427956PLXNC1chr12

94676177

+TXNRD1chr12

104742131

+
intron-3UTRENST00000551495ENST00000427956PLXNC1chr12

94676177

+TXNRD1chr12

104742130

+
intron-3UTRENST00000551495ENST00000526950PLXNC1chr12

94676177

+TXNRD1chr12

104742131

+
intron-3UTRENST00000551495ENST00000526950PLXNC1chr12

94676177

+TXNRD1chr12

104742130

+
intron-intronENST00000551495ENST00000526006PLXNC1chr12

94676177

+TXNRD1chr12

104742131

+
intron-intronENST00000551495ENST00000526006PLXNC1chr12

94676177

+TXNRD1chr12

104742130

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000258526PLXNC1chr1294676177+ENST00000540716TXNRD1chr12104742131+464441283341901385
ENST00000547057PLXNC1chr1294676177+ENST00000540716TXNRD1chr12104742131+177312571411319392
ENST00000545312PLXNC1chr1294676177+ENST00000540716TXNRD1chr12104742131+1188672267734155
ENST00000258526PLXNC1chr1294676177+ENST00000540716TXNRD1chr12104742130+464441283341901385
ENST00000547057PLXNC1chr1294676177+ENST00000540716TXNRD1chr12104742130+177312571411319392
ENST00000545312PLXNC1chr1294676177+ENST00000540716TXNRD1chr12104742130+1188672267734155

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000258526ENST00000540716PLXNC1chr1294676177+TXNRD1chr12104742131+0.0005143550.9994856
ENST00000547057ENST00000540716PLXNC1chr1294676177+TXNRD1chr12104742131+0.0007276950.9992723
ENST00000545312ENST00000540716PLXNC1chr1294676177+TXNRD1chr12104742131+0.256721880.7432781
ENST00000258526ENST00000540716PLXNC1chr1294676177+TXNRD1chr12104742130+0.0005143550.9994856
ENST00000547057ENST00000540716PLXNC1chr1294676177+TXNRD1chr12104742130+0.0007276950.9992723
ENST00000545312ENST00000540716PLXNC1chr1294676177+TXNRD1chr12104742130+0.256721880.7432781

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Fusion Genomic Features for PLXNC1-TXNRD1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PLXNC1chr1294676177+TXNRD1chr12104742130+0.001855660.9981444
PLXNC1chr1294676177+TXNRD1chr12104742130+0.001855660.9981444
PLXNC1chr1294676177+TXNRD1chr12104742130+0.001855660.9981444
PLXNC1chr1294676177+TXNRD1chr12104742130+0.001855660.9981444

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PLXNC1-TXNRD1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:94676177/chr12:104742131)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePLXNC1chr12:94676177chr12:104742130ENST00000258526+233135_45212931569.0DomainSema
HgenePLXNC1chr12:94676177chr12:104742131ENST00000258526+233135_45212931569.0DomainSema
HgenePLXNC1chr12:94676177chr12:104742130ENST00000258526+233135_94412931569.0Topological domainExtracellular
HgenePLXNC1chr12:94676177chr12:104742131ENST00000258526+233135_94412931569.0Topological domainExtracellular
HgenePLXNC1chr12:94676177chr12:104742130ENST00000258526+2331945_96512931569.0TransmembraneHelical
HgenePLXNC1chr12:94676177chr12:104742131ENST00000258526+2331945_96512931569.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePLXNC1chr12:94676177chr12:104742130ENST00000258526+2331966_156812931569.0Topological domainCytoplasmic
HgenePLXNC1chr12:94676177chr12:104742131ENST00000258526+2331966_156812931569.0Topological domainCytoplasmic
TgeneTXNRD1chr12:94676177chr12:104742130ENST00000388854131556_156529550.0DomainGlutaredoxin
TgeneTXNRD1chr12:94676177chr12:104742130ENST00000503506131556_156477500.0DomainGlutaredoxin
TgeneTXNRD1chr12:94676177chr12:104742130ENST00000524698131556_156477500.0DomainGlutaredoxin
TgeneTXNRD1chr12:94676177chr12:104742130ENST00000525566151756_156627650.0DomainGlutaredoxin
TgeneTXNRD1chr12:94676177chr12:104742130ENST00000526390151756_156521544.0DomainGlutaredoxin
TgeneTXNRD1chr12:94676177chr12:104742130ENST00000526691131556_156529552.0DomainGlutaredoxin
TgeneTXNRD1chr12:94676177chr12:104742131ENST00000388854131556_156529550.0DomainGlutaredoxin
TgeneTXNRD1chr12:94676177chr12:104742131ENST00000503506131556_156477500.0DomainGlutaredoxin
TgeneTXNRD1chr12:94676177chr12:104742131ENST00000524698131556_156477500.0DomainGlutaredoxin
TgeneTXNRD1chr12:94676177chr12:104742131ENST00000525566151756_156627650.0DomainGlutaredoxin
TgeneTXNRD1chr12:94676177chr12:104742131ENST00000526390151756_156521544.0DomainGlutaredoxin
TgeneTXNRD1chr12:94676177chr12:104742131ENST00000526691131556_156529552.0DomainGlutaredoxin
TgeneTXNRD1chr12:94676177chr12:104742130ENST000003888541315192_209529550.0Nucleotide bindingFAD
TgeneTXNRD1chr12:94676177chr12:104742130ENST000005035061315192_209477500.0Nucleotide bindingFAD
TgeneTXNRD1chr12:94676177chr12:104742130ENST000005246981315192_209477500.0Nucleotide bindingFAD
TgeneTXNRD1chr12:94676177chr12:104742130ENST000005255661517192_209627650.0Nucleotide bindingFAD
TgeneTXNRD1chr12:94676177chr12:104742130ENST000005263901517192_209521544.0Nucleotide bindingFAD
TgeneTXNRD1chr12:94676177chr12:104742130ENST000005266911315192_209529552.0Nucleotide bindingFAD
TgeneTXNRD1chr12:94676177chr12:104742131ENST000003888541315192_209529550.0Nucleotide bindingFAD
TgeneTXNRD1chr12:94676177chr12:104742131ENST000005035061315192_209477500.0Nucleotide bindingFAD
TgeneTXNRD1chr12:94676177chr12:104742131ENST000005246981315192_209477500.0Nucleotide bindingFAD
TgeneTXNRD1chr12:94676177chr12:104742131ENST000005255661517192_209627650.0Nucleotide bindingFAD
TgeneTXNRD1chr12:94676177chr12:104742131ENST000005263901517192_209521544.0Nucleotide bindingFAD
TgeneTXNRD1chr12:94676177chr12:104742131ENST000005266911315192_209529552.0Nucleotide bindingFAD


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Fusion Gene Sequence for PLXNC1-TXNRD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>66588_66588_1_PLXNC1-TXNRD1_PLXNC1_chr12_94676177_ENST00000258526_TXNRD1_chr12_104742130_ENST00000540716_length(transcript)=4644nt_BP=4128nt
GCGAGGAGGAAACGGTGCCGGAGCGCGCAGGGCTTGCTGCCGCCACCGCCGCTGCACAGGCTGCCGGAGCGAGCCTGCCGCGCGCCGCCC
TCCCCGCTCTCCTTCCTGGGCGAGCTGCGGGGATGGGGCGGCCGCGGGAGCCCGAGCGCGCGCAGGAACCGCCGCCGCCGCCGCCCGCGT
CTCCGTTGCCGCGCGCCTGAGCCGCCGTCGCCGCCGCGCGCCCTGCCCGGGGGCGGCCCCCCCAGCCCCATGGAGGTCTCCCGGAGGAAG
GCGCCGCCGCGCCCCCCGCGCCCCGCAGCGCCACTGCCCCTGCTCGCCTATCTGCTGGCACTGGCGGCTCCCGGCCGGGGCGCGGACGAG
CCCGTGTGGCGGTCGGAGCAAGCCATCGGAGCCATCGCGGCGAGCCAGGAGGACGGCGTGTTTGTGGCGAGCGGCAGCTGCCTGGACCAG
CTGGACTACAGCCTGGAGCACAGCCTCTCGCGCCTGTACCGGGACCAAGCGGGCAACTGCACAGAGCCGGTCTCGCTGGCGCCCCCCGCG
CGGCCCCGGCCCGGGAGCAGCTTCAGCAAGCTGCTGCTGCCCTACCGCGAGGGGGCGGCCGGCCTCGGGGGGCTGCTGCTCACCGGCTGG
ACCTTCGACCGGGGCGCCTGCGAGGTGCGGCCCCTGGGCAACCTGAGCCGCAACTCCCTGCGCAACGGCACCGAGGTGGTGTCGTGCCAC
CCGCAGGGCTCGACGGCCGGCGTGGTGTACCGCGCGGGCCGGAACAACCGCTGGTACCTGGCGGTGGCCGCCACCTACGTGCTGCCTGAG
CCGGAGACGGCGAGCCGCTGCAACCCCGCGGCATCCGACCACGACACGGCCATCGCGCTCAAGGACACGGAGGGGCGCAGCCTGGCCACG
CAGGAGCTGGGGCGCCTCAAGCTGTGCGAGGGCGCGGGCAGCCTGCACTTCGTGGACGCCTTTCTCTGGAACGGCAGCATCTACTTCCCC
TACTACCCCTACAACTACACGAGCGGCGCTGCCACCGGCTGGCCCAGCATGGCGCGCATCGCGCAGAGCACCGAGGTGCTGTTCCAGGGC
CAGGCATCCCTCGACTGCGGCCACGGCCACCCCGACGGCCGCCGCCTGCTCCTCTCCTCCAGCCTAGTGGAGGCCCTGGACGTCTGGGCG
GGAGTGTTCAGCGCGGCCGCTGGAGAGGGCCAGGAGCGGCGCTCCCCCACCACCACGGCGCTCTGCCTCTTCAGAATGAGTGAGATCCAG
GCGCGCGCCAAGAGGGTCAGCTGGGACTTCAAGACGGCCGAGAGCCACTGCAAAGAAGGGGATCAACCTGAAAGAGTCCAACCAATCGCA
TCATCTACCTTGATCCATTCCGACCTGACATCCGTTTATGGCACCGTGGTAATGAACAGGACTGTTTTATTCTTGGGGACTGGAGATGGC
CAGTTACTTAAGGTTATTCTTGGTGAGAATTTGACTTCAAATTGTCCAGAGGTTATCTATGAAATTAAAGAAGAGACACCTGTTTTCTAC
AAACTCGTTCCTGATCCTGTGAAGAATATCTACATTTATCTAACAGCTGGGAAAGAGGTGAGGAGAATTCGTGTTGCAAACTGCAATAAA
CATAAATCCTGTTCGGAGTGTTTAACAGCCACAGACCCTCACTGCGGTTGGTGCCATTCGCTACAAAGGTGCACTTTTCAAGGAGATTGT
GTACATTCAGAGAACTTAGAAAACTGGCTGGATATTTCGTCTGGAGCAAAAAAGTGCCCTAAAATTCAGATAATTCGAAGCAGTAAAGAA
AAGACTACAGTGACTATGGTGGGAAGCTTCTCTCCAAGACACTCAAAGTGCATGGTGAAGAATGTGGACTCTAGCAGGGAGCTCTGCCAG
AATAAAAGTCAGCCCAACCGGACCTGCACCTGTAGCATCCCAACCAGAGCAACCTACAAAGATGTTTCAGTTGTCAACGTGATGTTCTCC
TTCGGTTCTTGGAATTTATCAGACAGATTCAACTTTACCAACTGCTCATCATTAAAAGAATGCCCAGCATGCGTAGAAACTGGCTGCGCG
TGGTGTAAAAGTGCAAGAAGGTGTATCCACCCCTTCACAGCTTGCGACCCTTCTGATTATGAGAGAAACCAGGAACAGTGTCCAGTGGCT
GTCGAGAAGACATCAGGAGGAGGAAGACCCAAGGAGAACAAGGGGAACAGAACCAACCAGGCTTTACAGGTCTTCTACATTAAGTCCATT
GAGCCACAGAAAGTATCGACATTAGGGAAAAGCAACGTGATAGTAACGGGAGCAAACTTTACCCGGGCATCGAACATCACAATGATCCTG
AAAGGAACCAGTACCTGTGATAAGGATGTGATACAGGTTAGCCATGTGCTAAATGACACCCACATGAAATTCTCTCTTCCATCAAGCCGG
AAAGAAATGAAGGATGTGTGTATCCAGTTTGATGGTGGGAACTGCTCTTCTGTGGGATCCTTATCCTACATTGCTCTGCCACATTGTTCC
CTTATATTTCCTGCTACCACCTGGATCAGTGGTGGTCAAAATATAACCATGATGGGCAGAAATTTTGATGTAATTGACAACTTAATCATT
TCACATGAATTAAAAGGAAACATAAATGTCTCTGAATATTGTGTGGCGACTTACTGCGGGTTTTTAGCCCCCAGTTTAAAGAGTTCAAAA
GTGCGCACGAATGTCACTGTGAAGCTGAGAGTACAAGACACCTACTTGGATTGTGGAACCCTGCAGTATCGGGAGGACCCCAGATTCACG
GGGTATCGGGTGGAATCCGAGGTGGACACAGAACTGGAAGTGAAAATTCAAAAAGAAAATGACAACTTCAACATTTCCAAAAAAGACATT
GAAATTACTCTCTTCCATGGGGAAAATGGGCAATTAAATTGCAGTTTTGAAAATATTACTAGAAATCAAGATCTTACCACCATCCTTTGC
AAAATTAAAGGCATCAAGACTGCAAGCACCATTGCCAACTCTTCTAAGAAAGTTCGGGTCAAGCTGGGAAACCTGGAGCTCTACGTCGAG
CAGGAGTCAGTTCCTTCCACATGGTATTTTCTGATTGTGCTCCCTGTCTTGCTAGTGATTGTCATTTTTGCGGCCGTGGGGGTGACCAGG
CACAAATCGAAGGAGCTGAGTCGCAAACAGAGTCAACAACTAGAATTGCTGGAAAGCGAGCTCCGGAAAGAGATACGTGACGGCTTTGCT
GAGCTGCAGATGGATAAATTGGATGTGGTTGATAGTTTTGGAACTGTTCCCTTCCTTGACTACAAACATTTTGCTCTGAGAACTTTCTTC
CCTGAGTCAGGTGGCTTCACCCACATCTTCACTGAAGATATGCATAACAGAGACGCCAACGACAAGAATGAAAGTCTCACAGCTTTGGAT
GCCCTAATCTGTAATAAAAGCTTTCTTGTTACTGTCATCCACACCCTTGAAAAGCAGAAGAACTTTTCTGTGAAGGACAGGTGTCTGTTT
GCCTCCTTCCTAACCATTGCACTGCAAACCAAGCTGGTCTACCTGACCAGCATCCTAGAGGTGCTGACCAGGGACTTGATGGAACAGTGT
AGTAACATGCAGCCGAAACTCATGCTGAGACGCACGGAGTCCGTCGTCGAAAAACTCCTCACAAACTGGATGTCCGTCTGCCTTTCTGGA
TTTCTCCGGGAGACTGTCGGAGAGCCCTTCTATTTGCTGGTGACGACTCTGAACCAGAAAATTAACAAGGGTCCCGTGGATGTAATCACT
TGCAAAGCCCTGTACACACTTAATGAAGACTGGCTGTTGTGGCAGGTTCCGGAATTCAGTACTGTGGCATTAAACGTCGTCTTTGAAAAA
ATCCCGGAAAACGAGAGTGCAGATGTCTGTCGGAATATTTCAGTCAATGTTCTCGACTGTGACACCATTGGCCAAGCCAAAGAAAAGATT
TTCCAAGCATTCTTAAGCAAAAATGGCTCTCCTTATGGACTTCAGCTTAATGAAATTGGTCTTGAGCTTCAAATGGGCACACGACAGAAA
GAACTTCTGGACATCGACAGTTCCTCCGTGATTCTTGAAGATGGAATCACCAAGCTAAACACCATTGGCCACTATGAGGTATTCACAACA
TTGTCTGTGACCAAGCGCTCTGGGGCAAGCATCCTCCAGGCTGGCTGCTGAGGTTAAGCCCCAGTGTGGATGCTGTTGCCAAGACTGCAA
ACCACTGGCTCGTTTCCGTGCCCAAATCCAAGGCGAAGTTTTCTAGAGGGTTCTTGGGCTCTTGGCACCTGCGTGTCCTGTGCTTACCAC
CGCCCAAGGCCCCCTTGGATCTCTTGGATAGGAGTTGGTGAATAGAAGGCAGGCAGCATCACACTGGGGTCACTGACAGACTTGAAGCTG
ACATTTGGCAGGGCATCGAAGGGATGCATCCATGAAGTCACCAGTCTCAAGCCCATGTGGTAGGCGGTGATGGAACAACTGTCAAATCAG
TTTTAGCATGACCTTTCCTTGTGGATTTTCTTATTCTCGTTGTCAAGTTTTCTAGGGTTGAATTTTTTTCTTTTTTCTCCATGGTGTTAA

>66588_66588_1_PLXNC1-TXNRD1_PLXNC1_chr12_94676177_ENST00000258526_TXNRD1_chr12_104742130_ENST00000540716_length(amino acids)=1385AA_BP=1365
MLPPPPLHRLPERACRAPPSPLSFLGELRGWGGRGSPSARRNRRRRRPRLRCRAPEPPSPPRALPGGGPPSPMEVSRRKAPPRPPRPAAP
LPLLAYLLALAAPGRGADEPVWRSEQAIGAIAASQEDGVFVASGSCLDQLDYSLEHSLSRLYRDQAGNCTEPVSLAPPARPRPGSSFSKL
LLPYREGAAGLGGLLLTGWTFDRGACEVRPLGNLSRNSLRNGTEVVSCHPQGSTAGVVYRAGRNNRWYLAVAATYVLPEPETASRCNPAA
SDHDTAIALKDTEGRSLATQELGRLKLCEGAGSLHFVDAFLWNGSIYFPYYPYNYTSGAATGWPSMARIAQSTEVLFQGQASLDCGHGHP
DGRRLLLSSSLVEALDVWAGVFSAAAGEGQERRSPTTTALCLFRMSEIQARAKRVSWDFKTAESHCKEGDQPERVQPIASSTLIHSDLTS
VYGTVVMNRTVLFLGTGDGQLLKVILGENLTSNCPEVIYEIKEETPVFYKLVPDPVKNIYIYLTAGKEVRRIRVANCNKHKSCSECLTAT
DPHCGWCHSLQRCTFQGDCVHSENLENWLDISSGAKKCPKIQIIRSSKEKTTVTMVGSFSPRHSKCMVKNVDSSRELCQNKSQPNRTCTC
SIPTRATYKDVSVVNVMFSFGSWNLSDRFNFTNCSSLKECPACVETGCAWCKSARRCIHPFTACDPSDYERNQEQCPVAVEKTSGGGRPK
ENKGNRTNQALQVFYIKSIEPQKVSTLGKSNVIVTGANFTRASNITMILKGTSTCDKDVIQVSHVLNDTHMKFSLPSSRKEMKDVCIQFD
GGNCSSVGSLSYIALPHCSLIFPATTWISGGQNITMMGRNFDVIDNLIISHELKGNINVSEYCVATYCGFLAPSLKSSKVRTNVTVKLRV
QDTYLDCGTLQYREDPRFTGYRVESEVDTELEVKIQKENDNFNISKKDIEITLFHGENGQLNCSFENITRNQDLTTILCKIKGIKTASTI
ANSSKKVRVKLGNLELYVEQESVPSTWYFLIVLPVLLVIVIFAAVGVTRHKSKELSRKQSQQLELLESELRKEIRDGFAELQMDKLDVVD
SFGTVPFLDYKHFALRTFFPESGGFTHIFTEDMHNRDANDKNESLTALDALICNKSFLVTVIHTLEKQKNFSVKDRCLFASFLTIALQTK
LVYLTSILEVLTRDLMEQCSNMQPKLMLRRTESVVEKLLTNWMSVCLSGFLRETVGEPFYLLVTTLNQKINKGPVDVITCKALYTLNEDW
LLWQVPEFSTVALNVVFEKIPENESADVCRNISVNVLDCDTIGQAKEKIFQAFLSKNGSPYGLQLNEIGLELQMGTRQKELLDIDSSSVI

--------------------------------------------------------------
>66588_66588_2_PLXNC1-TXNRD1_PLXNC1_chr12_94676177_ENST00000258526_TXNRD1_chr12_104742131_ENST00000540716_length(transcript)=4644nt_BP=4128nt
GCGAGGAGGAAACGGTGCCGGAGCGCGCAGGGCTTGCTGCCGCCACCGCCGCTGCACAGGCTGCCGGAGCGAGCCTGCCGCGCGCCGCCC
TCCCCGCTCTCCTTCCTGGGCGAGCTGCGGGGATGGGGCGGCCGCGGGAGCCCGAGCGCGCGCAGGAACCGCCGCCGCCGCCGCCCGCGT
CTCCGTTGCCGCGCGCCTGAGCCGCCGTCGCCGCCGCGCGCCCTGCCCGGGGGCGGCCCCCCCAGCCCCATGGAGGTCTCCCGGAGGAAG
GCGCCGCCGCGCCCCCCGCGCCCCGCAGCGCCACTGCCCCTGCTCGCCTATCTGCTGGCACTGGCGGCTCCCGGCCGGGGCGCGGACGAG
CCCGTGTGGCGGTCGGAGCAAGCCATCGGAGCCATCGCGGCGAGCCAGGAGGACGGCGTGTTTGTGGCGAGCGGCAGCTGCCTGGACCAG
CTGGACTACAGCCTGGAGCACAGCCTCTCGCGCCTGTACCGGGACCAAGCGGGCAACTGCACAGAGCCGGTCTCGCTGGCGCCCCCCGCG
CGGCCCCGGCCCGGGAGCAGCTTCAGCAAGCTGCTGCTGCCCTACCGCGAGGGGGCGGCCGGCCTCGGGGGGCTGCTGCTCACCGGCTGG
ACCTTCGACCGGGGCGCCTGCGAGGTGCGGCCCCTGGGCAACCTGAGCCGCAACTCCCTGCGCAACGGCACCGAGGTGGTGTCGTGCCAC
CCGCAGGGCTCGACGGCCGGCGTGGTGTACCGCGCGGGCCGGAACAACCGCTGGTACCTGGCGGTGGCCGCCACCTACGTGCTGCCTGAG
CCGGAGACGGCGAGCCGCTGCAACCCCGCGGCATCCGACCACGACACGGCCATCGCGCTCAAGGACACGGAGGGGCGCAGCCTGGCCACG
CAGGAGCTGGGGCGCCTCAAGCTGTGCGAGGGCGCGGGCAGCCTGCACTTCGTGGACGCCTTTCTCTGGAACGGCAGCATCTACTTCCCC
TACTACCCCTACAACTACACGAGCGGCGCTGCCACCGGCTGGCCCAGCATGGCGCGCATCGCGCAGAGCACCGAGGTGCTGTTCCAGGGC
CAGGCATCCCTCGACTGCGGCCACGGCCACCCCGACGGCCGCCGCCTGCTCCTCTCCTCCAGCCTAGTGGAGGCCCTGGACGTCTGGGCG
GGAGTGTTCAGCGCGGCCGCTGGAGAGGGCCAGGAGCGGCGCTCCCCCACCACCACGGCGCTCTGCCTCTTCAGAATGAGTGAGATCCAG
GCGCGCGCCAAGAGGGTCAGCTGGGACTTCAAGACGGCCGAGAGCCACTGCAAAGAAGGGGATCAACCTGAAAGAGTCCAACCAATCGCA
TCATCTACCTTGATCCATTCCGACCTGACATCCGTTTATGGCACCGTGGTAATGAACAGGACTGTTTTATTCTTGGGGACTGGAGATGGC
CAGTTACTTAAGGTTATTCTTGGTGAGAATTTGACTTCAAATTGTCCAGAGGTTATCTATGAAATTAAAGAAGAGACACCTGTTTTCTAC
AAACTCGTTCCTGATCCTGTGAAGAATATCTACATTTATCTAACAGCTGGGAAAGAGGTGAGGAGAATTCGTGTTGCAAACTGCAATAAA
CATAAATCCTGTTCGGAGTGTTTAACAGCCACAGACCCTCACTGCGGTTGGTGCCATTCGCTACAAAGGTGCACTTTTCAAGGAGATTGT
GTACATTCAGAGAACTTAGAAAACTGGCTGGATATTTCGTCTGGAGCAAAAAAGTGCCCTAAAATTCAGATAATTCGAAGCAGTAAAGAA
AAGACTACAGTGACTATGGTGGGAAGCTTCTCTCCAAGACACTCAAAGTGCATGGTGAAGAATGTGGACTCTAGCAGGGAGCTCTGCCAG
AATAAAAGTCAGCCCAACCGGACCTGCACCTGTAGCATCCCAACCAGAGCAACCTACAAAGATGTTTCAGTTGTCAACGTGATGTTCTCC
TTCGGTTCTTGGAATTTATCAGACAGATTCAACTTTACCAACTGCTCATCATTAAAAGAATGCCCAGCATGCGTAGAAACTGGCTGCGCG
TGGTGTAAAAGTGCAAGAAGGTGTATCCACCCCTTCACAGCTTGCGACCCTTCTGATTATGAGAGAAACCAGGAACAGTGTCCAGTGGCT
GTCGAGAAGACATCAGGAGGAGGAAGACCCAAGGAGAACAAGGGGAACAGAACCAACCAGGCTTTACAGGTCTTCTACATTAAGTCCATT
GAGCCACAGAAAGTATCGACATTAGGGAAAAGCAACGTGATAGTAACGGGAGCAAACTTTACCCGGGCATCGAACATCACAATGATCCTG
AAAGGAACCAGTACCTGTGATAAGGATGTGATACAGGTTAGCCATGTGCTAAATGACACCCACATGAAATTCTCTCTTCCATCAAGCCGG
AAAGAAATGAAGGATGTGTGTATCCAGTTTGATGGTGGGAACTGCTCTTCTGTGGGATCCTTATCCTACATTGCTCTGCCACATTGTTCC
CTTATATTTCCTGCTACCACCTGGATCAGTGGTGGTCAAAATATAACCATGATGGGCAGAAATTTTGATGTAATTGACAACTTAATCATT
TCACATGAATTAAAAGGAAACATAAATGTCTCTGAATATTGTGTGGCGACTTACTGCGGGTTTTTAGCCCCCAGTTTAAAGAGTTCAAAA
GTGCGCACGAATGTCACTGTGAAGCTGAGAGTACAAGACACCTACTTGGATTGTGGAACCCTGCAGTATCGGGAGGACCCCAGATTCACG
GGGTATCGGGTGGAATCCGAGGTGGACACAGAACTGGAAGTGAAAATTCAAAAAGAAAATGACAACTTCAACATTTCCAAAAAAGACATT
GAAATTACTCTCTTCCATGGGGAAAATGGGCAATTAAATTGCAGTTTTGAAAATATTACTAGAAATCAAGATCTTACCACCATCCTTTGC
AAAATTAAAGGCATCAAGACTGCAAGCACCATTGCCAACTCTTCTAAGAAAGTTCGGGTCAAGCTGGGAAACCTGGAGCTCTACGTCGAG
CAGGAGTCAGTTCCTTCCACATGGTATTTTCTGATTGTGCTCCCTGTCTTGCTAGTGATTGTCATTTTTGCGGCCGTGGGGGTGACCAGG
CACAAATCGAAGGAGCTGAGTCGCAAACAGAGTCAACAACTAGAATTGCTGGAAAGCGAGCTCCGGAAAGAGATACGTGACGGCTTTGCT
GAGCTGCAGATGGATAAATTGGATGTGGTTGATAGTTTTGGAACTGTTCCCTTCCTTGACTACAAACATTTTGCTCTGAGAACTTTCTTC
CCTGAGTCAGGTGGCTTCACCCACATCTTCACTGAAGATATGCATAACAGAGACGCCAACGACAAGAATGAAAGTCTCACAGCTTTGGAT
GCCCTAATCTGTAATAAAAGCTTTCTTGTTACTGTCATCCACACCCTTGAAAAGCAGAAGAACTTTTCTGTGAAGGACAGGTGTCTGTTT
GCCTCCTTCCTAACCATTGCACTGCAAACCAAGCTGGTCTACCTGACCAGCATCCTAGAGGTGCTGACCAGGGACTTGATGGAACAGTGT
AGTAACATGCAGCCGAAACTCATGCTGAGACGCACGGAGTCCGTCGTCGAAAAACTCCTCACAAACTGGATGTCCGTCTGCCTTTCTGGA
TTTCTCCGGGAGACTGTCGGAGAGCCCTTCTATTTGCTGGTGACGACTCTGAACCAGAAAATTAACAAGGGTCCCGTGGATGTAATCACT
TGCAAAGCCCTGTACACACTTAATGAAGACTGGCTGTTGTGGCAGGTTCCGGAATTCAGTACTGTGGCATTAAACGTCGTCTTTGAAAAA
ATCCCGGAAAACGAGAGTGCAGATGTCTGTCGGAATATTTCAGTCAATGTTCTCGACTGTGACACCATTGGCCAAGCCAAAGAAAAGATT
TTCCAAGCATTCTTAAGCAAAAATGGCTCTCCTTATGGACTTCAGCTTAATGAAATTGGTCTTGAGCTTCAAATGGGCACACGACAGAAA
GAACTTCTGGACATCGACAGTTCCTCCGTGATTCTTGAAGATGGAATCACCAAGCTAAACACCATTGGCCACTATGAGGTATTCACAACA
TTGTCTGTGACCAAGCGCTCTGGGGCAAGCATCCTCCAGGCTGGCTGCTGAGGTTAAGCCCCAGTGTGGATGCTGTTGCCAAGACTGCAA
ACCACTGGCTCGTTTCCGTGCCCAAATCCAAGGCGAAGTTTTCTAGAGGGTTCTTGGGCTCTTGGCACCTGCGTGTCCTGTGCTTACCAC
CGCCCAAGGCCCCCTTGGATCTCTTGGATAGGAGTTGGTGAATAGAAGGCAGGCAGCATCACACTGGGGTCACTGACAGACTTGAAGCTG
ACATTTGGCAGGGCATCGAAGGGATGCATCCATGAAGTCACCAGTCTCAAGCCCATGTGGTAGGCGGTGATGGAACAACTGTCAAATCAG
TTTTAGCATGACCTTTCCTTGTGGATTTTCTTATTCTCGTTGTCAAGTTTTCTAGGGTTGAATTTTTTTCTTTTTTCTCCATGGTGTTAA

>66588_66588_2_PLXNC1-TXNRD1_PLXNC1_chr12_94676177_ENST00000258526_TXNRD1_chr12_104742131_ENST00000540716_length(amino acids)=1385AA_BP=1365
MLPPPPLHRLPERACRAPPSPLSFLGELRGWGGRGSPSARRNRRRRRPRLRCRAPEPPSPPRALPGGGPPSPMEVSRRKAPPRPPRPAAP
LPLLAYLLALAAPGRGADEPVWRSEQAIGAIAASQEDGVFVASGSCLDQLDYSLEHSLSRLYRDQAGNCTEPVSLAPPARPRPGSSFSKL
LLPYREGAAGLGGLLLTGWTFDRGACEVRPLGNLSRNSLRNGTEVVSCHPQGSTAGVVYRAGRNNRWYLAVAATYVLPEPETASRCNPAA
SDHDTAIALKDTEGRSLATQELGRLKLCEGAGSLHFVDAFLWNGSIYFPYYPYNYTSGAATGWPSMARIAQSTEVLFQGQASLDCGHGHP
DGRRLLLSSSLVEALDVWAGVFSAAAGEGQERRSPTTTALCLFRMSEIQARAKRVSWDFKTAESHCKEGDQPERVQPIASSTLIHSDLTS
VYGTVVMNRTVLFLGTGDGQLLKVILGENLTSNCPEVIYEIKEETPVFYKLVPDPVKNIYIYLTAGKEVRRIRVANCNKHKSCSECLTAT
DPHCGWCHSLQRCTFQGDCVHSENLENWLDISSGAKKCPKIQIIRSSKEKTTVTMVGSFSPRHSKCMVKNVDSSRELCQNKSQPNRTCTC
SIPTRATYKDVSVVNVMFSFGSWNLSDRFNFTNCSSLKECPACVETGCAWCKSARRCIHPFTACDPSDYERNQEQCPVAVEKTSGGGRPK
ENKGNRTNQALQVFYIKSIEPQKVSTLGKSNVIVTGANFTRASNITMILKGTSTCDKDVIQVSHVLNDTHMKFSLPSSRKEMKDVCIQFD
GGNCSSVGSLSYIALPHCSLIFPATTWISGGQNITMMGRNFDVIDNLIISHELKGNINVSEYCVATYCGFLAPSLKSSKVRTNVTVKLRV
QDTYLDCGTLQYREDPRFTGYRVESEVDTELEVKIQKENDNFNISKKDIEITLFHGENGQLNCSFENITRNQDLTTILCKIKGIKTASTI
ANSSKKVRVKLGNLELYVEQESVPSTWYFLIVLPVLLVIVIFAAVGVTRHKSKELSRKQSQQLELLESELRKEIRDGFAELQMDKLDVVD
SFGTVPFLDYKHFALRTFFPESGGFTHIFTEDMHNRDANDKNESLTALDALICNKSFLVTVIHTLEKQKNFSVKDRCLFASFLTIALQTK
LVYLTSILEVLTRDLMEQCSNMQPKLMLRRTESVVEKLLTNWMSVCLSGFLRETVGEPFYLLVTTLNQKINKGPVDVITCKALYTLNEDW
LLWQVPEFSTVALNVVFEKIPENESADVCRNISVNVLDCDTIGQAKEKIFQAFLSKNGSPYGLQLNEIGLELQMGTRQKELLDIDSSSVI

--------------------------------------------------------------
>66588_66588_3_PLXNC1-TXNRD1_PLXNC1_chr12_94676177_ENST00000545312_TXNRD1_chr12_104742130_ENST00000540716_length(transcript)=1188nt_BP=672nt
ACAGTGCTGATTCAAGAGCGTCTCGAGCACTCTGAGTGGTGAGGGGGCGGCTCGGCTCGCCAGGAGGAAGTGGCATCCAGCCAGTCGGCG
ATACTTTCACTTTCAGTGGAATAATTCCCGCTGGTGCAGGGGTCTGATGTCCCTCCACCAGGTGCTCAAGGGGGTCTGGGACACCGACAG
CCCTAGTCCTCCTGTCCTACCCCACAGACGTTTAGTGGGTGACAGTAGCTCCGTGACCGCCAGGAGACTGTCGGAGAGCCCTTCTATTTG
CTGGTGACGACTCTGAACCAGAAAATTAACAAGGGTCCCGTGGATGTAATCACTTGCAAAGCCCTGTACACACTTAATGAAGACTGGCTG
TTGTGGCAGGTTCCGGAATTCAGTACTGTGGCATTAAACGTCGTCTTTGAAAAAATCCCGGAAAACGAGAGTGCAGATGTCTGTCGGAAT
ATTTCAGTCAATGTTCTCGACTGTGACACCATTGGCCAAGCCAAAGAAAAGATTTTCCAAGCATTCTTAAGCAAAAATGGCTCTCCTTAT
GGACTTCAGCTTAATGAAATTGGTCTTGAGCTTCAAATGGGCACACGACAGAAAGAACTTCTGGACATCGACAGTTCCTCCGTGATTCTT
GAAGATGGAATCACCAAGCTAAACACCATTGGCCACTATGAGGTATTCACAACATTGTCTGTGACCAAGCGCTCTGGGGCAAGCATCCTC
CAGGCTGGCTGCTGAGGTTAAGCCCCAGTGTGGATGCTGTTGCCAAGACTGCAAACCACTGGCTCGTTTCCGTGCCCAAATCCAAGGCGA
AGTTTTCTAGAGGGTTCTTGGGCTCTTGGCACCTGCGTGTCCTGTGCTTACCACCGCCCAAGGCCCCCTTGGATCTCTTGGATAGGAGTT
GGTGAATAGAAGGCAGGCAGCATCACACTGGGGTCACTGACAGACTTGAAGCTGACATTTGGCAGGGCATCGAAGGGATGCATCCATGAA
GTCACCAGTCTCAAGCCCATGTGGTAGGCGGTGATGGAACAACTGTCAAATCAGTTTTAGCATGACCTTTCCTTGTGGATTTTCTTATTC
TCGTTGTCAAGTTTTCTAGGGTTGAATTTTTTTCTTTTTTCTCCATGGTGTTAATGATATTAGAGATGAAAAACGTTAGCAGTTGATTTT

>66588_66588_3_PLXNC1-TXNRD1_PLXNC1_chr12_94676177_ENST00000545312_TXNRD1_chr12_104742130_ENST00000540716_length(amino acids)=155AA_BP=135
MLVTTLNQKINKGPVDVITCKALYTLNEDWLLWQVPEFSTVALNVVFEKIPENESADVCRNISVNVLDCDTIGQAKEKIFQAFLSKNGSP

--------------------------------------------------------------
>66588_66588_4_PLXNC1-TXNRD1_PLXNC1_chr12_94676177_ENST00000545312_TXNRD1_chr12_104742131_ENST00000540716_length(transcript)=1188nt_BP=672nt
ACAGTGCTGATTCAAGAGCGTCTCGAGCACTCTGAGTGGTGAGGGGGCGGCTCGGCTCGCCAGGAGGAAGTGGCATCCAGCCAGTCGGCG
ATACTTTCACTTTCAGTGGAATAATTCCCGCTGGTGCAGGGGTCTGATGTCCCTCCACCAGGTGCTCAAGGGGGTCTGGGACACCGACAG
CCCTAGTCCTCCTGTCCTACCCCACAGACGTTTAGTGGGTGACAGTAGCTCCGTGACCGCCAGGAGACTGTCGGAGAGCCCTTCTATTTG
CTGGTGACGACTCTGAACCAGAAAATTAACAAGGGTCCCGTGGATGTAATCACTTGCAAAGCCCTGTACACACTTAATGAAGACTGGCTG
TTGTGGCAGGTTCCGGAATTCAGTACTGTGGCATTAAACGTCGTCTTTGAAAAAATCCCGGAAAACGAGAGTGCAGATGTCTGTCGGAAT
ATTTCAGTCAATGTTCTCGACTGTGACACCATTGGCCAAGCCAAAGAAAAGATTTTCCAAGCATTCTTAAGCAAAAATGGCTCTCCTTAT
GGACTTCAGCTTAATGAAATTGGTCTTGAGCTTCAAATGGGCACACGACAGAAAGAACTTCTGGACATCGACAGTTCCTCCGTGATTCTT
GAAGATGGAATCACCAAGCTAAACACCATTGGCCACTATGAGGTATTCACAACATTGTCTGTGACCAAGCGCTCTGGGGCAAGCATCCTC
CAGGCTGGCTGCTGAGGTTAAGCCCCAGTGTGGATGCTGTTGCCAAGACTGCAAACCACTGGCTCGTTTCCGTGCCCAAATCCAAGGCGA
AGTTTTCTAGAGGGTTCTTGGGCTCTTGGCACCTGCGTGTCCTGTGCTTACCACCGCCCAAGGCCCCCTTGGATCTCTTGGATAGGAGTT
GGTGAATAGAAGGCAGGCAGCATCACACTGGGGTCACTGACAGACTTGAAGCTGACATTTGGCAGGGCATCGAAGGGATGCATCCATGAA
GTCACCAGTCTCAAGCCCATGTGGTAGGCGGTGATGGAACAACTGTCAAATCAGTTTTAGCATGACCTTTCCTTGTGGATTTTCTTATTC
TCGTTGTCAAGTTTTCTAGGGTTGAATTTTTTTCTTTTTTCTCCATGGTGTTAATGATATTAGAGATGAAAAACGTTAGCAGTTGATTTT

>66588_66588_4_PLXNC1-TXNRD1_PLXNC1_chr12_94676177_ENST00000545312_TXNRD1_chr12_104742131_ENST00000540716_length(amino acids)=155AA_BP=135
MLVTTLNQKINKGPVDVITCKALYTLNEDWLLWQVPEFSTVALNVVFEKIPENESADVCRNISVNVLDCDTIGQAKEKIFQAFLSKNGSP

--------------------------------------------------------------
>66588_66588_5_PLXNC1-TXNRD1_PLXNC1_chr12_94676177_ENST00000547057_TXNRD1_chr12_104742130_ENST00000540716_length(transcript)=1773nt_BP=1257nt
ACTTGTAAAATGAGTAAGGTTTTGGTTTTTTTCTGCTGCATTTTGGCATCTTCCTCTTCAGAGTGACCCCTCACTGGGAAATTTTCTTAT
AAGATCCAGCTTTTTAATGCTATTTTCTAGTTTCATTCTAGCTCCTGCTCTCTGTCCCTATCTGTTTTGTTTTTGTTTTTGTTTTTAAGA
ACTGTAAAGATTGCTATTTGTTTTCATTTTTGGTTTTTGAGTTACCATGTCCCTCTGATGCAGCATCTCTGTCTCTTAGCGGCCGTGGGG
GTGACCAGGCACAAATCGAAGGAGCTGAGTCGCAAACAGAGTCAACAACTAGAATTGCTGGAAAGCGAGCTCCGGAAAGAGATACGTGAC
GGCTTTGCTGAGCTGCAGATGGATAAATTGGATGTGGTTGATAGTTTTGGAACTGTTCCCTTCCTTGACTACAAACATTTTGCTCTGAGA
ACTTTCTTCCCTGAGTCAGGTGGCTTCACCCACATCTTCACTGAAGATATGCATAACAGAGACGCCAACGACAAGAATGAAAGTCTCACA
GCTTTGGATGCCCTAATCTGTAATAAAAGCTTTCTTGTTACTGTCATCCACACCCTTGAAAAGCAGAAGAACTTTTCTGTGAAGGACAGG
TGTCTGTTTGCCTCCTTCCTAACCATTGCACTGCAAACCAAGCTGGTCTACCTGACCAGCATCCTAGAGGTGCTGACCAGGGACTTGATG
GAACAGTGTAGTAACATGCAGCCGAAACTCATGCTGAGACGCACGGAGTCCGTCGTCGAAAAACTCCTCACAAACTGGATGTCCGTCTGC
CTTTCTGGATTTCTCCGGGAGACTGTCGGAGAGCCCTTCTATTTGCTGGTGACGACTCTGAACCAGAAAATTAACAAGGGTCCCGTGGAT
GTAATCACTTGCAAAGCCCTGTACACACTTAATGAAGACTGGCTGTTGTGGCAGGTTCCGGAATTCAGTACTGTGGCATTAAACGTCGTC
TTTGAAAAAATCCCGGAAAACGAGAGTGCAGATGTCTGTCGGAATATTTCAGTCAATGTTCTCGACTGTGACACCATTGGCCAAGCCAAA
GAAAAGATTTTCCAAGCATTCTTAAGCAAAAATGGCTCTCCTTATGGACTTCAGCTTAATGAAATTGGTCTTGAGCTTCAAATGGGCACA
CGACAGAAAGAACTTCTGGACATCGACAGTTCCTCCGTGATTCTTGAAGATGGAATCACCAAGCTAAACACCATTGGCCACTATGAGGTA
TTCACAACATTGTCTGTGACCAAGCGCTCTGGGGCAAGCATCCTCCAGGCTGGCTGCTGAGGTTAAGCCCCAGTGTGGATGCTGTTGCCA
AGACTGCAAACCACTGGCTCGTTTCCGTGCCCAAATCCAAGGCGAAGTTTTCTAGAGGGTTCTTGGGCTCTTGGCACCTGCGTGTCCTGT
GCTTACCACCGCCCAAGGCCCCCTTGGATCTCTTGGATAGGAGTTGGTGAATAGAAGGCAGGCAGCATCACACTGGGGTCACTGACAGAC
TTGAAGCTGACATTTGGCAGGGCATCGAAGGGATGCATCCATGAAGTCACCAGTCTCAAGCCCATGTGGTAGGCGGTGATGGAACAACTG
TCAAATCAGTTTTAGCATGACCTTTCCTTGTGGATTTTCTTATTCTCGTTGTCAAGTTTTCTAGGGTTGAATTTTTTTCTTTTTTCTCCA

>66588_66588_5_PLXNC1-TXNRD1_PLXNC1_chr12_94676177_ENST00000547057_TXNRD1_chr12_104742130_ENST00000540716_length(amino acids)=392AA_BP=372
MSLSVLFLFLFLRTVKIAICFHFWFLSYHVPLMQHLCLLAAVGVTRHKSKELSRKQSQQLELLESELRKEIRDGFAELQMDKLDVVDSFG
TVPFLDYKHFALRTFFPESGGFTHIFTEDMHNRDANDKNESLTALDALICNKSFLVTVIHTLEKQKNFSVKDRCLFASFLTIALQTKLVY
LTSILEVLTRDLMEQCSNMQPKLMLRRTESVVEKLLTNWMSVCLSGFLRETVGEPFYLLVTTLNQKINKGPVDVITCKALYTLNEDWLLW
QVPEFSTVALNVVFEKIPENESADVCRNISVNVLDCDTIGQAKEKIFQAFLSKNGSPYGLQLNEIGLELQMGTRQKELLDIDSSSVILED

--------------------------------------------------------------
>66588_66588_6_PLXNC1-TXNRD1_PLXNC1_chr12_94676177_ENST00000547057_TXNRD1_chr12_104742131_ENST00000540716_length(transcript)=1773nt_BP=1257nt
ACTTGTAAAATGAGTAAGGTTTTGGTTTTTTTCTGCTGCATTTTGGCATCTTCCTCTTCAGAGTGACCCCTCACTGGGAAATTTTCTTAT
AAGATCCAGCTTTTTAATGCTATTTTCTAGTTTCATTCTAGCTCCTGCTCTCTGTCCCTATCTGTTTTGTTTTTGTTTTTGTTTTTAAGA
ACTGTAAAGATTGCTATTTGTTTTCATTTTTGGTTTTTGAGTTACCATGTCCCTCTGATGCAGCATCTCTGTCTCTTAGCGGCCGTGGGG
GTGACCAGGCACAAATCGAAGGAGCTGAGTCGCAAACAGAGTCAACAACTAGAATTGCTGGAAAGCGAGCTCCGGAAAGAGATACGTGAC
GGCTTTGCTGAGCTGCAGATGGATAAATTGGATGTGGTTGATAGTTTTGGAACTGTTCCCTTCCTTGACTACAAACATTTTGCTCTGAGA
ACTTTCTTCCCTGAGTCAGGTGGCTTCACCCACATCTTCACTGAAGATATGCATAACAGAGACGCCAACGACAAGAATGAAAGTCTCACA
GCTTTGGATGCCCTAATCTGTAATAAAAGCTTTCTTGTTACTGTCATCCACACCCTTGAAAAGCAGAAGAACTTTTCTGTGAAGGACAGG
TGTCTGTTTGCCTCCTTCCTAACCATTGCACTGCAAACCAAGCTGGTCTACCTGACCAGCATCCTAGAGGTGCTGACCAGGGACTTGATG
GAACAGTGTAGTAACATGCAGCCGAAACTCATGCTGAGACGCACGGAGTCCGTCGTCGAAAAACTCCTCACAAACTGGATGTCCGTCTGC
CTTTCTGGATTTCTCCGGGAGACTGTCGGAGAGCCCTTCTATTTGCTGGTGACGACTCTGAACCAGAAAATTAACAAGGGTCCCGTGGAT
GTAATCACTTGCAAAGCCCTGTACACACTTAATGAAGACTGGCTGTTGTGGCAGGTTCCGGAATTCAGTACTGTGGCATTAAACGTCGTC
TTTGAAAAAATCCCGGAAAACGAGAGTGCAGATGTCTGTCGGAATATTTCAGTCAATGTTCTCGACTGTGACACCATTGGCCAAGCCAAA
GAAAAGATTTTCCAAGCATTCTTAAGCAAAAATGGCTCTCCTTATGGACTTCAGCTTAATGAAATTGGTCTTGAGCTTCAAATGGGCACA
CGACAGAAAGAACTTCTGGACATCGACAGTTCCTCCGTGATTCTTGAAGATGGAATCACCAAGCTAAACACCATTGGCCACTATGAGGTA
TTCACAACATTGTCTGTGACCAAGCGCTCTGGGGCAAGCATCCTCCAGGCTGGCTGCTGAGGTTAAGCCCCAGTGTGGATGCTGTTGCCA
AGACTGCAAACCACTGGCTCGTTTCCGTGCCCAAATCCAAGGCGAAGTTTTCTAGAGGGTTCTTGGGCTCTTGGCACCTGCGTGTCCTGT
GCTTACCACCGCCCAAGGCCCCCTTGGATCTCTTGGATAGGAGTTGGTGAATAGAAGGCAGGCAGCATCACACTGGGGTCACTGACAGAC
TTGAAGCTGACATTTGGCAGGGCATCGAAGGGATGCATCCATGAAGTCACCAGTCTCAAGCCCATGTGGTAGGCGGTGATGGAACAACTG
TCAAATCAGTTTTAGCATGACCTTTCCTTGTGGATTTTCTTATTCTCGTTGTCAAGTTTTCTAGGGTTGAATTTTTTTCTTTTTTCTCCA

>66588_66588_6_PLXNC1-TXNRD1_PLXNC1_chr12_94676177_ENST00000547057_TXNRD1_chr12_104742131_ENST00000540716_length(amino acids)=392AA_BP=372
MSLSVLFLFLFLRTVKIAICFHFWFLSYHVPLMQHLCLLAAVGVTRHKSKELSRKQSQQLELLESELRKEIRDGFAELQMDKLDVVDSFG
TVPFLDYKHFALRTFFPESGGFTHIFTEDMHNRDANDKNESLTALDALICNKSFLVTVIHTLEKQKNFSVKDRCLFASFLTIALQTKLVY
LTSILEVLTRDLMEQCSNMQPKLMLRRTESVVEKLLTNWMSVCLSGFLRETVGEPFYLLVTTLNQKINKGPVDVITCKALYTLNEDWLLW
QVPEFSTVALNVVFEKIPENESADVCRNISVNVLDCDTIGQAKEKIFQAFLSKNGSPYGLQLNEIGLELQMGTRQKELLDIDSSSVILED

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PLXNC1-TXNRD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PLXNC1-TXNRD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PLXNC1-TXNRD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource