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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PMEL-MORC2 (FusionGDB2 ID:66604)

Fusion Gene Summary for PMEL-MORC2

check button Fusion gene summary
Fusion gene informationFusion gene name: PMEL-MORC2
Fusion gene ID: 66604
HgeneTgene
Gene symbol

PMEL

MORC2

Gene ID

6490

22880

Gene namepremelanosome proteinMORC family CW-type zinc finger 2
SynonymsD12S53E|ME20|ME20-M|ME20M|P1|P100|PMEL17|SI|SIL|SILV|gp100CMT2Z|ZCW3|ZCWCC1
Cytomap

12q13.2

22q12.2

Type of geneprotein-codingprotein-coding
Descriptionmelanocyte protein PMELmelanocyte protein Pmel 17melanocyte protein mel 17melanocytes lineage-specific antigen GP100melanoma-associated ME20 antigenmelanosomal matrix protein17silver locus protein homologsilver, mouse, homolog ofATPase MORC2zinc finger CW-type coiled-coil domain protein 1
Modification date2020031320200313
UniProtAcc.

Q9Y6X9

Ensembl transtripts involved in fusion geneENST00000360714, ENST00000449260, 
ENST00000536427, ENST00000539511, 
ENST00000548493, ENST00000548747, 
ENST00000550447, ENST00000550464, 
ENST00000552882, ENST00000548689, 
ENST00000215862, ENST00000469915, 
ENST00000397641, 
Fusion gene scores* DoF score8 X 5 X 2=805 X 5 X 5=125
# samples 85
** MAII scorelog2(8/80*10)=0log2(5/125*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PMEL [Title/Abstract] AND MORC2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPMEL(56359720)-MORC2(31346431), # samples:1
Anticipated loss of major functional domain due to fusion event.PMEL-MORC2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PMEL-MORC2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePMEL

GO:0032438

melanosome organization

11694580

TgeneMORC2

GO:0006338

chromatin remodeling

23260667

TgeneMORC2

GO:0006974

cellular response to DNA damage stimulus

23260667

TgeneMORC2

GO:0045814

negative regulation of gene expression, epigenetic

28581500|29211708

TgeneMORC2

GO:0090309

positive regulation of methylation-dependent chromatin silencing

28581500|29211708


check buttonFusion gene breakpoints across PMEL (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MORC2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-EE-A3AE-06APMELchr12

56359720

-MORC2chr22

31346431

-


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Fusion Gene ORF analysis for PMEL-MORC2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000360714ENST00000215862PMELchr12

56359720

-MORC2chr22

31346431

-
5CDS-5UTRENST00000449260ENST00000215862PMELchr12

56359720

-MORC2chr22

31346431

-
5CDS-5UTRENST00000536427ENST00000215862PMELchr12

56359720

-MORC2chr22

31346431

-
5CDS-5UTRENST00000539511ENST00000215862PMELchr12

56359720

-MORC2chr22

31346431

-
5CDS-5UTRENST00000548493ENST00000215862PMELchr12

56359720

-MORC2chr22

31346431

-
5CDS-5UTRENST00000548747ENST00000215862PMELchr12

56359720

-MORC2chr22

31346431

-
5CDS-5UTRENST00000550447ENST00000215862PMELchr12

56359720

-MORC2chr22

31346431

-
5CDS-5UTRENST00000550464ENST00000215862PMELchr12

56359720

-MORC2chr22

31346431

-
5CDS-5UTRENST00000552882ENST00000215862PMELchr12

56359720

-MORC2chr22

31346431

-
5CDS-intronENST00000360714ENST00000469915PMELchr12

56359720

-MORC2chr22

31346431

-
5CDS-intronENST00000449260ENST00000469915PMELchr12

56359720

-MORC2chr22

31346431

-
5CDS-intronENST00000536427ENST00000469915PMELchr12

56359720

-MORC2chr22

31346431

-
5CDS-intronENST00000539511ENST00000469915PMELchr12

56359720

-MORC2chr22

31346431

-
5CDS-intronENST00000548493ENST00000469915PMELchr12

56359720

-MORC2chr22

31346431

-
5CDS-intronENST00000548747ENST00000469915PMELchr12

56359720

-MORC2chr22

31346431

-
5CDS-intronENST00000550447ENST00000469915PMELchr12

56359720

-MORC2chr22

31346431

-
5CDS-intronENST00000550464ENST00000469915PMELchr12

56359720

-MORC2chr22

31346431

-
5CDS-intronENST00000552882ENST00000469915PMELchr12

56359720

-MORC2chr22

31346431

-
Frame-shiftENST00000449260ENST00000397641PMELchr12

56359720

-MORC2chr22

31346431

-
Frame-shiftENST00000548747ENST00000397641PMELchr12

56359720

-MORC2chr22

31346431

-
Frame-shiftENST00000550447ENST00000397641PMELchr12

56359720

-MORC2chr22

31346431

-
Frame-shiftENST00000550464ENST00000397641PMELchr12

56359720

-MORC2chr22

31346431

-
Frame-shiftENST00000552882ENST00000397641PMELchr12

56359720

-MORC2chr22

31346431

-
In-frameENST00000360714ENST00000397641PMELchr12

56359720

-MORC2chr22

31346431

-
In-frameENST00000536427ENST00000397641PMELchr12

56359720

-MORC2chr22

31346431

-
In-frameENST00000539511ENST00000397641PMELchr12

56359720

-MORC2chr22

31346431

-
In-frameENST00000548493ENST00000397641PMELchr12

56359720

-MORC2chr22

31346431

-
intron-3CDSENST00000548689ENST00000397641PMELchr12

56359720

-MORC2chr22

31346431

-
intron-5UTRENST00000548689ENST00000215862PMELchr12

56359720

-MORC2chr22

31346431

-
intron-intronENST00000548689ENST00000469915PMELchr12

56359720

-MORC2chr22

31346431

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000536427PMELchr1256359720-ENST00000397641MORC2chr2231346431-47791642231051027
ENST00000539511PMELchr1256359720-ENST00000397641MORC2chr2231346431-47791642231051027
ENST00000360714PMELchr1256359720-ENST00000397641MORC2chr2231346431-47791642231051027
ENST00000548493PMELchr1256359720-ENST00000397641MORC2chr2231346431-48011864431271027

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000536427ENST00000397641PMELchr1256359720-MORC2chr2231346431-0.0008553060.9991447
ENST00000539511ENST00000397641PMELchr1256359720-MORC2chr2231346431-0.0008553060.9991447
ENST00000360714ENST00000397641PMELchr1256359720-MORC2chr2231346431-0.0008553060.9991447
ENST00000548493ENST00000397641PMELchr1256359720-MORC2chr2231346431-0.0009027890.9990972

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Fusion Genomic Features for PMEL-MORC2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PMEL-MORC2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:56359720/chr22:31346431)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MORC2

Q9Y6X9

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Essential for epigenetic silencing by the HUSH (human silencing hub) complex. Recruited by HUSH to target site in heterochromatin, the ATPase activity and homodimerization are critical for HUSH-mediated silencing (PubMed:28581500, PubMed:29440755). Represses germ cell-related genes and L1 retrotransposons in collaboration with SETDB1 and the HUSH complex, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). During DNA damage response, regulates chromatin remodeling through ATP hydrolysis. Upon DNA damage, is phosphorylated by PAK1, both colocalize to chromatin and induce H2AX expression. ATPase activity is required and dependent of phosphorylation by PAK1 and presence of DNA (PubMed:23260667). Recruits histone deacetylases, such as HDAC4, to promoter regions, causing local histone H3 deacetylation and transcriptional repression of genes such as CA9 (PubMed:20225202, PubMed:20110259). Exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY, possibly preventing its dephosphorylation (PubMed:24286864). {ECO:0000269|PubMed:20110259, ECO:0000269|PubMed:20225202, ECO:0000269|PubMed:23260667, ECO:0000269|PubMed:24286864, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:29440755}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMORC2chr12:56359720chr22:31346431ENST00000215862327282_3620971.0Coiled coilOntology_term=ECO:0000255
TgeneMORC2chr12:56359720chr22:31346431ENST00000215862327547_5840971.0Coiled coilOntology_term=ECO:0000255
TgeneMORC2chr12:56359720chr22:31346431ENST00000215862327741_7610971.0Coiled coilOntology_term=ECO:0000255
TgeneMORC2chr12:56359720chr22:31346431ENST00000215862327966_10160971.0Coiled coilOntology_term=ECO:0000255
TgeneMORC2chr12:56359720chr22:31346431ENST00000397641226282_362521033.0Coiled coilOntology_term=ECO:0000255
TgeneMORC2chr12:56359720chr22:31346431ENST00000397641226547_584521033.0Coiled coilOntology_term=ECO:0000255
TgeneMORC2chr12:56359720chr22:31346431ENST00000397641226741_761521033.0Coiled coilOntology_term=ECO:0000255
TgeneMORC2chr12:56359720chr22:31346431ENST00000397641226966_1016521033.0Coiled coilOntology_term=ECO:0000255
TgeneMORC2chr12:56359720chr22:31346431ENST0000021586232787_890971.0Nucleotide bindingATP
TgeneMORC2chr12:56359720chr22:31346431ENST0000021586232799_1050971.0Nucleotide bindingATP
TgeneMORC2chr12:56359720chr22:31346431ENST0000039764122687_89521033.0Nucleotide bindingATP
TgeneMORC2chr12:56359720chr22:31346431ENST0000039764122699_105521033.0Nucleotide bindingATP
TgeneMORC2chr12:56359720chr22:31346431ENST00000215862327490_5440971.0Zinc fingerCW-type
TgeneMORC2chr12:56359720chr22:31346431ENST00000397641226490_544521033.0Zinc fingerCW-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePMELchr12:56359720chr22:31346431ENST00000449260-111255_29225669.0DomainPKD
HgenePMELchr12:56359720chr22:31346431ENST00000539511-210255_29225576.0DomainPKD
HgenePMELchr12:56359720chr22:31346431ENST00000548493-212255_29225662.0DomainPKD
HgenePMELchr12:56359720chr22:31346431ENST00000548747-111255_29225662.0DomainPKD
HgenePMELchr12:56359720chr22:31346431ENST00000550464-19255_29225576.0DomainPKD
HgenePMELchr12:56359720chr22:31346431ENST00000552882-212255_29225662.0DomainPKD
HgenePMELchr12:56359720chr22:31346431ENST00000449260-111315_44425669.0RegionNote=10 X 13 AA approximate tandem repeats%2C RPT domain
HgenePMELchr12:56359720chr22:31346431ENST00000539511-210315_44425576.0RegionNote=10 X 13 AA approximate tandem repeats%2C RPT domain
HgenePMELchr12:56359720chr22:31346431ENST00000548493-212315_44425662.0RegionNote=10 X 13 AA approximate tandem repeats%2C RPT domain
HgenePMELchr12:56359720chr22:31346431ENST00000548747-111315_44425662.0RegionNote=10 X 13 AA approximate tandem repeats%2C RPT domain
HgenePMELchr12:56359720chr22:31346431ENST00000550464-19315_44425576.0RegionNote=10 X 13 AA approximate tandem repeats%2C RPT domain
HgenePMELchr12:56359720chr22:31346431ENST00000552882-212315_44425662.0RegionNote=10 X 13 AA approximate tandem repeats%2C RPT domain
HgenePMELchr12:56359720chr22:31346431ENST00000449260-111315_32725669.0RepeatNote=1
HgenePMELchr12:56359720chr22:31346431ENST00000449260-111328_34025669.0RepeatNote=2
HgenePMELchr12:56359720chr22:31346431ENST00000449260-111341_35325669.0RepeatNote=3
HgenePMELchr12:56359720chr22:31346431ENST00000449260-111354_36625669.0RepeatNote=4
HgenePMELchr12:56359720chr22:31346431ENST00000449260-111367_37925669.0RepeatNote=5
HgenePMELchr12:56359720chr22:31346431ENST00000449260-111380_39225669.0RepeatNote=6
HgenePMELchr12:56359720chr22:31346431ENST00000449260-111393_40525669.0RepeatNote=7
HgenePMELchr12:56359720chr22:31346431ENST00000449260-111406_41825669.0RepeatNote=8
HgenePMELchr12:56359720chr22:31346431ENST00000449260-111419_43125669.0RepeatNote=9
HgenePMELchr12:56359720chr22:31346431ENST00000449260-111432_44425669.0RepeatNote=10
HgenePMELchr12:56359720chr22:31346431ENST00000539511-210315_32725576.0RepeatNote=1
HgenePMELchr12:56359720chr22:31346431ENST00000539511-210328_34025576.0RepeatNote=2
HgenePMELchr12:56359720chr22:31346431ENST00000539511-210341_35325576.0RepeatNote=3
HgenePMELchr12:56359720chr22:31346431ENST00000539511-210354_36625576.0RepeatNote=4
HgenePMELchr12:56359720chr22:31346431ENST00000539511-210367_37925576.0RepeatNote=5
HgenePMELchr12:56359720chr22:31346431ENST00000539511-210380_39225576.0RepeatNote=6
HgenePMELchr12:56359720chr22:31346431ENST00000539511-210393_40525576.0RepeatNote=7
HgenePMELchr12:56359720chr22:31346431ENST00000539511-210406_41825576.0RepeatNote=8
HgenePMELchr12:56359720chr22:31346431ENST00000539511-210419_43125576.0RepeatNote=9
HgenePMELchr12:56359720chr22:31346431ENST00000539511-210432_44425576.0RepeatNote=10
HgenePMELchr12:56359720chr22:31346431ENST00000548493-212315_32725662.0RepeatNote=1
HgenePMELchr12:56359720chr22:31346431ENST00000548493-212328_34025662.0RepeatNote=2
HgenePMELchr12:56359720chr22:31346431ENST00000548493-212341_35325662.0RepeatNote=3
HgenePMELchr12:56359720chr22:31346431ENST00000548493-212354_36625662.0RepeatNote=4
HgenePMELchr12:56359720chr22:31346431ENST00000548493-212367_37925662.0RepeatNote=5
HgenePMELchr12:56359720chr22:31346431ENST00000548493-212380_39225662.0RepeatNote=6
HgenePMELchr12:56359720chr22:31346431ENST00000548493-212393_40525662.0RepeatNote=7
HgenePMELchr12:56359720chr22:31346431ENST00000548493-212406_41825662.0RepeatNote=8
HgenePMELchr12:56359720chr22:31346431ENST00000548493-212419_43125662.0RepeatNote=9
HgenePMELchr12:56359720chr22:31346431ENST00000548493-212432_44425662.0RepeatNote=10
HgenePMELchr12:56359720chr22:31346431ENST00000548747-111315_32725662.0RepeatNote=1
HgenePMELchr12:56359720chr22:31346431ENST00000548747-111328_34025662.0RepeatNote=2
HgenePMELchr12:56359720chr22:31346431ENST00000548747-111341_35325662.0RepeatNote=3
HgenePMELchr12:56359720chr22:31346431ENST00000548747-111354_36625662.0RepeatNote=4
HgenePMELchr12:56359720chr22:31346431ENST00000548747-111367_37925662.0RepeatNote=5
HgenePMELchr12:56359720chr22:31346431ENST00000548747-111380_39225662.0RepeatNote=6
HgenePMELchr12:56359720chr22:31346431ENST00000548747-111393_40525662.0RepeatNote=7
HgenePMELchr12:56359720chr22:31346431ENST00000548747-111406_41825662.0RepeatNote=8
HgenePMELchr12:56359720chr22:31346431ENST00000548747-111419_43125662.0RepeatNote=9
HgenePMELchr12:56359720chr22:31346431ENST00000548747-111432_44425662.0RepeatNote=10
HgenePMELchr12:56359720chr22:31346431ENST00000550464-19315_32725576.0RepeatNote=1
HgenePMELchr12:56359720chr22:31346431ENST00000550464-19328_34025576.0RepeatNote=2
HgenePMELchr12:56359720chr22:31346431ENST00000550464-19341_35325576.0RepeatNote=3
HgenePMELchr12:56359720chr22:31346431ENST00000550464-19354_36625576.0RepeatNote=4
HgenePMELchr12:56359720chr22:31346431ENST00000550464-19367_37925576.0RepeatNote=5
HgenePMELchr12:56359720chr22:31346431ENST00000550464-19380_39225576.0RepeatNote=6
HgenePMELchr12:56359720chr22:31346431ENST00000550464-19393_40525576.0RepeatNote=7
HgenePMELchr12:56359720chr22:31346431ENST00000550464-19406_41825576.0RepeatNote=8
HgenePMELchr12:56359720chr22:31346431ENST00000550464-19419_43125576.0RepeatNote=9
HgenePMELchr12:56359720chr22:31346431ENST00000550464-19432_44425576.0RepeatNote=10
HgenePMELchr12:56359720chr22:31346431ENST00000552882-212315_32725662.0RepeatNote=1
HgenePMELchr12:56359720chr22:31346431ENST00000552882-212328_34025662.0RepeatNote=2
HgenePMELchr12:56359720chr22:31346431ENST00000552882-212341_35325662.0RepeatNote=3
HgenePMELchr12:56359720chr22:31346431ENST00000552882-212354_36625662.0RepeatNote=4
HgenePMELchr12:56359720chr22:31346431ENST00000552882-212367_37925662.0RepeatNote=5
HgenePMELchr12:56359720chr22:31346431ENST00000552882-212380_39225662.0RepeatNote=6
HgenePMELchr12:56359720chr22:31346431ENST00000552882-212393_40525662.0RepeatNote=7
HgenePMELchr12:56359720chr22:31346431ENST00000552882-212406_41825662.0RepeatNote=8
HgenePMELchr12:56359720chr22:31346431ENST00000552882-212419_43125662.0RepeatNote=9
HgenePMELchr12:56359720chr22:31346431ENST00000552882-212432_44425662.0RepeatNote=10
HgenePMELchr12:56359720chr22:31346431ENST00000449260-111470_59525669.0Topological domainLumenal
HgenePMELchr12:56359720chr22:31346431ENST00000449260-111617_66125669.0Topological domainCytoplasmic
HgenePMELchr12:56359720chr22:31346431ENST00000539511-210470_59525576.0Topological domainLumenal
HgenePMELchr12:56359720chr22:31346431ENST00000539511-210617_66125576.0Topological domainCytoplasmic
HgenePMELchr12:56359720chr22:31346431ENST00000548493-212470_59525662.0Topological domainLumenal
HgenePMELchr12:56359720chr22:31346431ENST00000548493-212617_66125662.0Topological domainCytoplasmic
HgenePMELchr12:56359720chr22:31346431ENST00000548747-111470_59525662.0Topological domainLumenal
HgenePMELchr12:56359720chr22:31346431ENST00000548747-111617_66125662.0Topological domainCytoplasmic
HgenePMELchr12:56359720chr22:31346431ENST00000550464-19470_59525576.0Topological domainLumenal
HgenePMELchr12:56359720chr22:31346431ENST00000550464-19617_66125576.0Topological domainCytoplasmic
HgenePMELchr12:56359720chr22:31346431ENST00000552882-212470_59525662.0Topological domainLumenal
HgenePMELchr12:56359720chr22:31346431ENST00000552882-212617_66125662.0Topological domainCytoplasmic
HgenePMELchr12:56359720chr22:31346431ENST00000449260-111596_61625669.0TransmembraneHelical
HgenePMELchr12:56359720chr22:31346431ENST00000539511-210596_61625576.0TransmembraneHelical
HgenePMELchr12:56359720chr22:31346431ENST00000548493-212596_61625662.0TransmembraneHelical
HgenePMELchr12:56359720chr22:31346431ENST00000548747-111596_61625662.0TransmembraneHelical
HgenePMELchr12:56359720chr22:31346431ENST00000550464-19596_61625576.0TransmembraneHelical
HgenePMELchr12:56359720chr22:31346431ENST00000552882-212596_61625662.0TransmembraneHelical


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Fusion Gene Sequence for PMEL-MORC2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>66604_66604_1_PMEL-MORC2_PMEL_chr12_56359720_ENST00000360714_MORC2_chr22_31346431_ENST00000397641_length(transcript)=4779nt_BP=164nt
AGCCCAGCGCTCCTCCCCGCAAATGATCCCGCCCCAGGGGCCTATCCCAGTCCCCCCAGTGCCTTTGGTTGCTGGAGGGAAGAACACAAT
GGATCTGGTGCTAAAAAGATGCCTTCTTCATTTGGCTGTGATAGGTGCTTTGCTGGCTGTGGGGGCTACAAAAGAAAGACGAGAGGACCT
TCGAGGAGGATTTATGCTTTGCTTTTTGGATGATGGAGCAGGAATGGATCCAAGTGATGCTGCCAGTGTGATCCAGTTTGGGAAGTCGGC
CAAGCGAACACCTGAGTCTACTCAGATTGGGCAGTACGGGAATGGGTTAAAATCGGGCTCAATGCGCATTGGGAAGGATTTTATCCTGTT
CACCAAGAAGGAAGACACCATGACCTGCCTCTTCCTGTCTCGCACGTTTCATGAGGAAGAAGGCATTGATGAAGTGATAGTCCCACTGCC
CACCTGGAATGCTCGGACCCGGGAACCTGTCACAGACAATGTAGAGAAATTTGCCATTGAGACAGAACTCATCTATAAGTACTCTCCATT
CCGCACTGAGGAGGAAGTGATGACCCAGTTTATGAAGATTCCTGGGGACAGCGGAACATTGGTGATCATCTTCAATCTCAAACTCATGGA
TAATGGAGAGCCAGAACTAGACATAATCTCAAATCCAAGAGATATCCAGATGGCAGAGACGTCCCCAGAGGGCACGAAGCCAGAGCGGCG
CTCGTTCCGTGCCTATGCCGCTGTGCTCTATATTGATCCCCGGATGAGGATCTTCATCCATGGGCACAAGGTGCAGACCAAGAGGCTCTC
CTGCTGCCTGTACAAGCCCAGGATGTACAAGTACACGTCAAGCCGTTTCAAGACCCGTGCGGAGCAGGAGGTGAAGAAAGCAGAGCACGT
AGCAAGGATTGCTGAAGAGAAGGCGCGGGAGGCAGAGAGCAAAGCTCGGACATTAGAAGTACGCCTAGGTGGAGACCTCACGCGGGACTC
CAGGGTGATGTTGCGACAGGTCCAGAACAGAGCCATCACTCTGCGCAGAGAAGCCGATGTCAAGAAGAGGATCAAGGAGGCCAAGCAGCG
AGCACTTAAAGAACCTAAGGAACTGAATTTTGTTTTTGGTGTCAACATTGAACACCGGGATCTGGATGGCATGTTCATCTACAACTGTAG
CCGACTGATCAAAATGTATGAGAAAGTGGGCCCACAGCTGGAAGGGGGCATGGCATGTGGCGGGGTTGTTGGGGTTGTTGATGTGCCCTA
CCTGGTCCTGGAGCCTACACACAACAAACAGGACTTTGCTGATGCCAAGGAGTACCGGCACCTGCTCCGAGCAATGGGGGAGCACCTGGC
GCAGTATTGGAAGGATATTGCCATCGCCCAGAGGGGAATCATCAAGTTCTGGGATGAGTTTGGCTACCTCTCTGCCAACTGGAACCAGCC
CCCATCCAGTGAGCTGCGTTACAAACGCCGGAGAGCTATGGAAATCCCCACCACCATCCAGTGCGATTTGTGTCTGAAATGGAGAACCCT
CCCCTTCCAGCTGAGTTCTGTGGAAAAAGATTACCCTGACACCTGGGTTTGCTCCATGAACCCTGATCCTGAACAGGACCGGTGTGAGGC
TTCTGAACAAAAGCAGAAGGTTCCCCTGGGAACATTCAGAAAGGACATGAAGACGCAGGAAGAGAAGCAGAAACAACTGACAGAGAAAAT
TCGCCAGCAGCAGGAGAAGCTGGAGGCCCTTCAGAAAACCACACCCATCCGCTCCCAAGCAGACCTGAAGAAATTGCCCTTGGAAGTGAC
CACCAGACCTTCCACTGAGGAACCTGTGCGTAGACCTCAGCGTCCTCGGTCGCCCCCTTTACCTGCTGTGATCAGGAACGCCCCCAGCAG
ACCCCCTTCTTTGCCAACTCCTAGACCAGCCAGCCAGCCCCGAAAGGCTCCTGTCATCAGCAGTACCCCAAAGCTCCCTGCTTTGGCAGC
CCGGGAGGAGGCCAGCACATCTAGGCTGCTCCAGCCACCTGAGGCACCCCGAAAGCCTGCCAACACTCTCGTCAAGACTGCATCCCGACC
TGCCCCTCTGGTGCAGCAACTGTCACCATCTTTACTGCCCAACTCCAAGAGCCCTCGGGAGGTTCCTTCTCCCAAAGTCATCAAGACTCC
AGTGGTGAAGAAGACAGAGTCACCCATCAAACTCTCCCCGGCTACCCCTAGTCGGAAGCGGAGTGTCGCAGTTTCTGATGAGGAAGAAGT
TGAGGAGGAAGCTGAGAGGAGGAAGGAGAGGTGCAAGCGGGGCAGATTTGTTGTGAAGGAGGAAAAGAAGGACTCGAATGAGCTCTCAGA
CAGTGCTGGGGAAGAGGACTCGGCTGACCTCAAGAGAGCTCAGAAAGATAAAGGGCTGCACGTGGAGGTGCGTGTGAACAGGGAGTGGTA
CACGGGCCGTGTCACAGCCGTGGAGGTGGGCAAGCATGTGGTGCGGTGGAAGGTGAAGTTTGACTACGTGCCCACAGACACGACACCAAG
AGACCGCTGGGTGGAGAAAGGCAGTGAGGATGTGCGGCTGATGAAACCCCCTTCTCCGGAACATCAGAGCCTTGATACACAACAGGAGGG
CGGGGAGGAGGAGGTGGGCCCTGTGGCCCAGCAGGCCATAGCTGTCGCAGAGCCCTCCACTTCCGAATGCCTCCGCATTGAGCCTGACAC
CACTGCCCTGAGCACCAATCACGAGACCATCGACCTGCTTGTCCAGATCCTCCGGAATTGTTTACGGTACTTCCTGCCTCCAAGTTTCCC
CATCTCCAAGAAGCAGCTGAGTGCTATGAATTCAGATGAGCTAATATCTTTTCCTCTGAAGGAGTACTTCAAGCAATATGAAGTAGGGCT
CCAAAACCTGTGCAATTCCTACCAGAGCCGTGCTGACTCCCGGGCCAAGGCCTCCGAGGAAAGCCTGCGCACCTCCGAGAGGAAGCTCCG
CGAGACGGAGGAGAAGCTGCAGAAGCTGAGGACCAACATCGTGGCACTCCTGCAAAAGGTGCAGGAGGACATAGACATCAACACAGATGA
TGAGCTGGACGCCTACATTGAGGACCTCATCACCAAGGGGGACTGAAGGCAGGAGAGAGAGCAGCTCCCCTGCCCACCTGCCCCTCAACC
CTGTAGCTGCAGGGGGAGGGGACTTCATTCATGGGTTGGTGGTCGCACCTTGGTTTGACTTACACGGGACATTTGTGTTTTTGGAGGAAA
AGATACCCTGATTCTTTGAATCTTCCTTAAGTTTATAAATATTTATTTTTTAAAAGAAGATGCTGTGCCTGTGAGACCATACTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTGGTGACTGCAAAGGACAGAGAACCTTTCCACTTTGGCCATACTGGGTTGCTAAGCCGGAGCC
ATTTCAGCTCCTGGCTCCTCAAGATAACGGCGAGTCCAGTGCCATCTTGGAGAAGCTCCAGGGGCAGGGCTGACTTTTCTCCTACAGGAG
GAACAATGTGGGGATCTGAGGGATGGGAGGGAGACTTCCCCCTAGAGTGGTGGTCCTGCTGGGGGCTCATATCCAGGGACCCAAAAGGGG
GGCTGTGTAGGAGGTTCCACATTGGAGGGGCTCTCTCTCTCGCAGCTGTCAGAGTTGGTCCTGGCTGTGGCGTCCAAACAGCTTGAGGGA
AAAAGATCCTGTCTAACCACCTCATCTACTACTCAAGTTCTTTCTGAAGGAGGGATTTCTTCAGTTAACCATGGACAGTGAGGTTTCTCA
CCACAGTAACTTGAGTCCAGGTTGAGGGGGAGACAGATCTGTGGTAAATCTCTGACTTGGGCAGCACACTGAGTGTGGAACCCCACAGGA
CTCCTTAGGGAAGGAGCTTGTGTGTGAAAGAACCCCTGGGGCTGAGCTGGTGACCTCCATGTGTGGGTGCAGCAGGGCCTTGGATGGTGC
CAATTGATCTGGACAGCCTGTTGATGCTTTTCTACTTCCACCCTTCGGCCTGGCCCCACTGAGCCCCATCAAGGTGCCTGAAGAGGGGGC
CAGTGAGATCCCGTGGCCACAGGGACTCCAGAGGCATCTCTGCAGGAAGCACACCATGCCTTCCCTCCATGTTCCATCACGGCGCCACAA
TCTGTGTCCCTTAACTTCTCAGGGTCAAAGACAAAGGCAAGCGTTGCTGAATTTTCTCTTTAATGGCCATTGGAAGAGTCTGGTTCAGTT
TTTCCCAACTCTCTTCCCACTCGTATTTGGGGCCTCTGGGTTTTCTGAAGGCACAAGGACTGTGACTTTGTACCACTAACCTGTGGTTCA
AACCTGGGTGTGTTTCTGGCATCTCCCTAACCCAGATCAGCAATGGCCACCCTGCTCCTCTGAGGTCAGCAGAAGACTGGGAAGCAGAGG
TGAGGGATGCAGGCCACACTGGAATGGGAAGTCTTTTCCCCACTGGATGTGCCTGTCTGGTGGGTTTTGGACCTTCCCAGACTACATCTC
TAGGAGAGGCCTGTTTGGAGTAGTACACTGAGAGACCCTGGCCTCTTCTGCTGGAAGACTGTCCAAGTCTTGGGGTTTCTTGAGCTGGTG
ATTCCTCTGCCATCCTGCTCTCTCTCTTCATCTCAGGCAGCATGGGGTCCACTTTTGTCCCCAAACCTAATGTTTTAATCCAAATGCAAA
TTGGTTCCACATTTTTACTGGAGGGTAATCAGTTTTTAAAATTCACACACATGTAATCGAAACGCAATACTATAAAGTTCTACTGGTGAG

>66604_66604_1_PMEL-MORC2_PMEL_chr12_56359720_ENST00000360714_MORC2_chr22_31346431_ENST00000397641_length(amino acids)=1027AA_BP=47
MIPPQGPIPVPPVPLVAGGKNTMDLVLKRCLLHLAVIGALLAVGATKERREDLRGGFMLCFLDDGAGMDPSDAASVIQFGKSAKRTPEST
QIGQYGNGLKSGSMRIGKDFILFTKKEDTMTCLFLSRTFHEEEGIDEVIVPLPTWNARTREPVTDNVEKFAIETELIYKYSPFRTEEEVM
TQFMKIPGDSGTLVIIFNLKLMDNGEPELDIISNPRDIQMAETSPEGTKPERRSFRAYAAVLYIDPRMRIFIHGHKVQTKRLSCCLYKPR
MYKYTSSRFKTRAEQEVKKAEHVARIAEEKAREAESKARTLEVRLGGDLTRDSRVMLRQVQNRAITLRREADVKKRIKEAKQRALKEPKE
LNFVFGVNIEHRDLDGMFIYNCSRLIKMYEKVGPQLEGGMACGGVVGVVDVPYLVLEPTHNKQDFADAKEYRHLLRAMGEHLAQYWKDIA
IAQRGIIKFWDEFGYLSANWNQPPSSELRYKRRRAMEIPTTIQCDLCLKWRTLPFQLSSVEKDYPDTWVCSMNPDPEQDRCEASEQKQKV
PLGTFRKDMKTQEEKQKQLTEKIRQQQEKLEALQKTTPIRSQADLKKLPLEVTTRPSTEEPVRRPQRPRSPPLPAVIRNAPSRPPSLPTP
RPASQPRKAPVISSTPKLPALAAREEASTSRLLQPPEAPRKPANTLVKTASRPAPLVQQLSPSLLPNSKSPREVPSPKVIKTPVVKKTES
PIKLSPATPSRKRSVAVSDEEEVEEEAERRKERCKRGRFVVKEEKKDSNELSDSAGEEDSADLKRAQKDKGLHVEVRVNREWYTGRVTAV
EVGKHVVRWKVKFDYVPTDTTPRDRWVEKGSEDVRLMKPPSPEHQSLDTQQEGGEEEVGPVAQQAIAVAEPSTSECLRIEPDTTALSTNH
ETIDLLVQILRNCLRYFLPPSFPISKKQLSAMNSDELISFPLKEYFKQYEVGLQNLCNSYQSRADSRAKASEESLRTSERKLRETEEKLQ

--------------------------------------------------------------
>66604_66604_2_PMEL-MORC2_PMEL_chr12_56359720_ENST00000536427_MORC2_chr22_31346431_ENST00000397641_length(transcript)=4779nt_BP=164nt
AGCCCAGCGCTCCTCCCCGCAAATGATCCCGCCCCAGGGGCCTATCCCAGTCCCCCCAGTGCCTTTGGTTGCTGGAGGGAAGAACACAAT
GGATCTGGTGCTAAAAAGATGCCTTCTTCATTTGGCTGTGATAGGTGCTTTGCTGGCTGTGGGGGCTACAAAAGAAAGACGAGAGGACCT
TCGAGGAGGATTTATGCTTTGCTTTTTGGATGATGGAGCAGGAATGGATCCAAGTGATGCTGCCAGTGTGATCCAGTTTGGGAAGTCGGC
CAAGCGAACACCTGAGTCTACTCAGATTGGGCAGTACGGGAATGGGTTAAAATCGGGCTCAATGCGCATTGGGAAGGATTTTATCCTGTT
CACCAAGAAGGAAGACACCATGACCTGCCTCTTCCTGTCTCGCACGTTTCATGAGGAAGAAGGCATTGATGAAGTGATAGTCCCACTGCC
CACCTGGAATGCTCGGACCCGGGAACCTGTCACAGACAATGTAGAGAAATTTGCCATTGAGACAGAACTCATCTATAAGTACTCTCCATT
CCGCACTGAGGAGGAAGTGATGACCCAGTTTATGAAGATTCCTGGGGACAGCGGAACATTGGTGATCATCTTCAATCTCAAACTCATGGA
TAATGGAGAGCCAGAACTAGACATAATCTCAAATCCAAGAGATATCCAGATGGCAGAGACGTCCCCAGAGGGCACGAAGCCAGAGCGGCG
CTCGTTCCGTGCCTATGCCGCTGTGCTCTATATTGATCCCCGGATGAGGATCTTCATCCATGGGCACAAGGTGCAGACCAAGAGGCTCTC
CTGCTGCCTGTACAAGCCCAGGATGTACAAGTACACGTCAAGCCGTTTCAAGACCCGTGCGGAGCAGGAGGTGAAGAAAGCAGAGCACGT
AGCAAGGATTGCTGAAGAGAAGGCGCGGGAGGCAGAGAGCAAAGCTCGGACATTAGAAGTACGCCTAGGTGGAGACCTCACGCGGGACTC
CAGGGTGATGTTGCGACAGGTCCAGAACAGAGCCATCACTCTGCGCAGAGAAGCCGATGTCAAGAAGAGGATCAAGGAGGCCAAGCAGCG
AGCACTTAAAGAACCTAAGGAACTGAATTTTGTTTTTGGTGTCAACATTGAACACCGGGATCTGGATGGCATGTTCATCTACAACTGTAG
CCGACTGATCAAAATGTATGAGAAAGTGGGCCCACAGCTGGAAGGGGGCATGGCATGTGGCGGGGTTGTTGGGGTTGTTGATGTGCCCTA
CCTGGTCCTGGAGCCTACACACAACAAACAGGACTTTGCTGATGCCAAGGAGTACCGGCACCTGCTCCGAGCAATGGGGGAGCACCTGGC
GCAGTATTGGAAGGATATTGCCATCGCCCAGAGGGGAATCATCAAGTTCTGGGATGAGTTTGGCTACCTCTCTGCCAACTGGAACCAGCC
CCCATCCAGTGAGCTGCGTTACAAACGCCGGAGAGCTATGGAAATCCCCACCACCATCCAGTGCGATTTGTGTCTGAAATGGAGAACCCT
CCCCTTCCAGCTGAGTTCTGTGGAAAAAGATTACCCTGACACCTGGGTTTGCTCCATGAACCCTGATCCTGAACAGGACCGGTGTGAGGC
TTCTGAACAAAAGCAGAAGGTTCCCCTGGGAACATTCAGAAAGGACATGAAGACGCAGGAAGAGAAGCAGAAACAACTGACAGAGAAAAT
TCGCCAGCAGCAGGAGAAGCTGGAGGCCCTTCAGAAAACCACACCCATCCGCTCCCAAGCAGACCTGAAGAAATTGCCCTTGGAAGTGAC
CACCAGACCTTCCACTGAGGAACCTGTGCGTAGACCTCAGCGTCCTCGGTCGCCCCCTTTACCTGCTGTGATCAGGAACGCCCCCAGCAG
ACCCCCTTCTTTGCCAACTCCTAGACCAGCCAGCCAGCCCCGAAAGGCTCCTGTCATCAGCAGTACCCCAAAGCTCCCTGCTTTGGCAGC
CCGGGAGGAGGCCAGCACATCTAGGCTGCTCCAGCCACCTGAGGCACCCCGAAAGCCTGCCAACACTCTCGTCAAGACTGCATCCCGACC
TGCCCCTCTGGTGCAGCAACTGTCACCATCTTTACTGCCCAACTCCAAGAGCCCTCGGGAGGTTCCTTCTCCCAAAGTCATCAAGACTCC
AGTGGTGAAGAAGACAGAGTCACCCATCAAACTCTCCCCGGCTACCCCTAGTCGGAAGCGGAGTGTCGCAGTTTCTGATGAGGAAGAAGT
TGAGGAGGAAGCTGAGAGGAGGAAGGAGAGGTGCAAGCGGGGCAGATTTGTTGTGAAGGAGGAAAAGAAGGACTCGAATGAGCTCTCAGA
CAGTGCTGGGGAAGAGGACTCGGCTGACCTCAAGAGAGCTCAGAAAGATAAAGGGCTGCACGTGGAGGTGCGTGTGAACAGGGAGTGGTA
CACGGGCCGTGTCACAGCCGTGGAGGTGGGCAAGCATGTGGTGCGGTGGAAGGTGAAGTTTGACTACGTGCCCACAGACACGACACCAAG
AGACCGCTGGGTGGAGAAAGGCAGTGAGGATGTGCGGCTGATGAAACCCCCTTCTCCGGAACATCAGAGCCTTGATACACAACAGGAGGG
CGGGGAGGAGGAGGTGGGCCCTGTGGCCCAGCAGGCCATAGCTGTCGCAGAGCCCTCCACTTCCGAATGCCTCCGCATTGAGCCTGACAC
CACTGCCCTGAGCACCAATCACGAGACCATCGACCTGCTTGTCCAGATCCTCCGGAATTGTTTACGGTACTTCCTGCCTCCAAGTTTCCC
CATCTCCAAGAAGCAGCTGAGTGCTATGAATTCAGATGAGCTAATATCTTTTCCTCTGAAGGAGTACTTCAAGCAATATGAAGTAGGGCT
CCAAAACCTGTGCAATTCCTACCAGAGCCGTGCTGACTCCCGGGCCAAGGCCTCCGAGGAAAGCCTGCGCACCTCCGAGAGGAAGCTCCG
CGAGACGGAGGAGAAGCTGCAGAAGCTGAGGACCAACATCGTGGCACTCCTGCAAAAGGTGCAGGAGGACATAGACATCAACACAGATGA
TGAGCTGGACGCCTACATTGAGGACCTCATCACCAAGGGGGACTGAAGGCAGGAGAGAGAGCAGCTCCCCTGCCCACCTGCCCCTCAACC
CTGTAGCTGCAGGGGGAGGGGACTTCATTCATGGGTTGGTGGTCGCACCTTGGTTTGACTTACACGGGACATTTGTGTTTTTGGAGGAAA
AGATACCCTGATTCTTTGAATCTTCCTTAAGTTTATAAATATTTATTTTTTAAAAGAAGATGCTGTGCCTGTGAGACCATACTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTGGTGACTGCAAAGGACAGAGAACCTTTCCACTTTGGCCATACTGGGTTGCTAAGCCGGAGCC
ATTTCAGCTCCTGGCTCCTCAAGATAACGGCGAGTCCAGTGCCATCTTGGAGAAGCTCCAGGGGCAGGGCTGACTTTTCTCCTACAGGAG
GAACAATGTGGGGATCTGAGGGATGGGAGGGAGACTTCCCCCTAGAGTGGTGGTCCTGCTGGGGGCTCATATCCAGGGACCCAAAAGGGG
GGCTGTGTAGGAGGTTCCACATTGGAGGGGCTCTCTCTCTCGCAGCTGTCAGAGTTGGTCCTGGCTGTGGCGTCCAAACAGCTTGAGGGA
AAAAGATCCTGTCTAACCACCTCATCTACTACTCAAGTTCTTTCTGAAGGAGGGATTTCTTCAGTTAACCATGGACAGTGAGGTTTCTCA
CCACAGTAACTTGAGTCCAGGTTGAGGGGGAGACAGATCTGTGGTAAATCTCTGACTTGGGCAGCACACTGAGTGTGGAACCCCACAGGA
CTCCTTAGGGAAGGAGCTTGTGTGTGAAAGAACCCCTGGGGCTGAGCTGGTGACCTCCATGTGTGGGTGCAGCAGGGCCTTGGATGGTGC
CAATTGATCTGGACAGCCTGTTGATGCTTTTCTACTTCCACCCTTCGGCCTGGCCCCACTGAGCCCCATCAAGGTGCCTGAAGAGGGGGC
CAGTGAGATCCCGTGGCCACAGGGACTCCAGAGGCATCTCTGCAGGAAGCACACCATGCCTTCCCTCCATGTTCCATCACGGCGCCACAA
TCTGTGTCCCTTAACTTCTCAGGGTCAAAGACAAAGGCAAGCGTTGCTGAATTTTCTCTTTAATGGCCATTGGAAGAGTCTGGTTCAGTT
TTTCCCAACTCTCTTCCCACTCGTATTTGGGGCCTCTGGGTTTTCTGAAGGCACAAGGACTGTGACTTTGTACCACTAACCTGTGGTTCA
AACCTGGGTGTGTTTCTGGCATCTCCCTAACCCAGATCAGCAATGGCCACCCTGCTCCTCTGAGGTCAGCAGAAGACTGGGAAGCAGAGG
TGAGGGATGCAGGCCACACTGGAATGGGAAGTCTTTTCCCCACTGGATGTGCCTGTCTGGTGGGTTTTGGACCTTCCCAGACTACATCTC
TAGGAGAGGCCTGTTTGGAGTAGTACACTGAGAGACCCTGGCCTCTTCTGCTGGAAGACTGTCCAAGTCTTGGGGTTTCTTGAGCTGGTG
ATTCCTCTGCCATCCTGCTCTCTCTCTTCATCTCAGGCAGCATGGGGTCCACTTTTGTCCCCAAACCTAATGTTTTAATCCAAATGCAAA
TTGGTTCCACATTTTTACTGGAGGGTAATCAGTTTTTAAAATTCACACACATGTAATCGAAACGCAATACTATAAAGTTCTACTGGTGAG

>66604_66604_2_PMEL-MORC2_PMEL_chr12_56359720_ENST00000536427_MORC2_chr22_31346431_ENST00000397641_length(amino acids)=1027AA_BP=47
MIPPQGPIPVPPVPLVAGGKNTMDLVLKRCLLHLAVIGALLAVGATKERREDLRGGFMLCFLDDGAGMDPSDAASVIQFGKSAKRTPEST
QIGQYGNGLKSGSMRIGKDFILFTKKEDTMTCLFLSRTFHEEEGIDEVIVPLPTWNARTREPVTDNVEKFAIETELIYKYSPFRTEEEVM
TQFMKIPGDSGTLVIIFNLKLMDNGEPELDIISNPRDIQMAETSPEGTKPERRSFRAYAAVLYIDPRMRIFIHGHKVQTKRLSCCLYKPR
MYKYTSSRFKTRAEQEVKKAEHVARIAEEKAREAESKARTLEVRLGGDLTRDSRVMLRQVQNRAITLRREADVKKRIKEAKQRALKEPKE
LNFVFGVNIEHRDLDGMFIYNCSRLIKMYEKVGPQLEGGMACGGVVGVVDVPYLVLEPTHNKQDFADAKEYRHLLRAMGEHLAQYWKDIA
IAQRGIIKFWDEFGYLSANWNQPPSSELRYKRRRAMEIPTTIQCDLCLKWRTLPFQLSSVEKDYPDTWVCSMNPDPEQDRCEASEQKQKV
PLGTFRKDMKTQEEKQKQLTEKIRQQQEKLEALQKTTPIRSQADLKKLPLEVTTRPSTEEPVRRPQRPRSPPLPAVIRNAPSRPPSLPTP
RPASQPRKAPVISSTPKLPALAAREEASTSRLLQPPEAPRKPANTLVKTASRPAPLVQQLSPSLLPNSKSPREVPSPKVIKTPVVKKTES
PIKLSPATPSRKRSVAVSDEEEVEEEAERRKERCKRGRFVVKEEKKDSNELSDSAGEEDSADLKRAQKDKGLHVEVRVNREWYTGRVTAV
EVGKHVVRWKVKFDYVPTDTTPRDRWVEKGSEDVRLMKPPSPEHQSLDTQQEGGEEEVGPVAQQAIAVAEPSTSECLRIEPDTTALSTNH
ETIDLLVQILRNCLRYFLPPSFPISKKQLSAMNSDELISFPLKEYFKQYEVGLQNLCNSYQSRADSRAKASEESLRTSERKLRETEEKLQ

--------------------------------------------------------------
>66604_66604_3_PMEL-MORC2_PMEL_chr12_56359720_ENST00000539511_MORC2_chr22_31346431_ENST00000397641_length(transcript)=4779nt_BP=164nt
AGCCCAGCGCTCCTCCCCGCAAATGATCCCGCCCCAGGGGCCTATCCCAGTCCCCCCAGTGCCTTTGGTTGCTGGAGGGAAGAACACAAT
GGATCTGGTGCTAAAAAGATGCCTTCTTCATTTGGCTGTGATAGGTGCTTTGCTGGCTGTGGGGGCTACAAAAGAAAGACGAGAGGACCT
TCGAGGAGGATTTATGCTTTGCTTTTTGGATGATGGAGCAGGAATGGATCCAAGTGATGCTGCCAGTGTGATCCAGTTTGGGAAGTCGGC
CAAGCGAACACCTGAGTCTACTCAGATTGGGCAGTACGGGAATGGGTTAAAATCGGGCTCAATGCGCATTGGGAAGGATTTTATCCTGTT
CACCAAGAAGGAAGACACCATGACCTGCCTCTTCCTGTCTCGCACGTTTCATGAGGAAGAAGGCATTGATGAAGTGATAGTCCCACTGCC
CACCTGGAATGCTCGGACCCGGGAACCTGTCACAGACAATGTAGAGAAATTTGCCATTGAGACAGAACTCATCTATAAGTACTCTCCATT
CCGCACTGAGGAGGAAGTGATGACCCAGTTTATGAAGATTCCTGGGGACAGCGGAACATTGGTGATCATCTTCAATCTCAAACTCATGGA
TAATGGAGAGCCAGAACTAGACATAATCTCAAATCCAAGAGATATCCAGATGGCAGAGACGTCCCCAGAGGGCACGAAGCCAGAGCGGCG
CTCGTTCCGTGCCTATGCCGCTGTGCTCTATATTGATCCCCGGATGAGGATCTTCATCCATGGGCACAAGGTGCAGACCAAGAGGCTCTC
CTGCTGCCTGTACAAGCCCAGGATGTACAAGTACACGTCAAGCCGTTTCAAGACCCGTGCGGAGCAGGAGGTGAAGAAAGCAGAGCACGT
AGCAAGGATTGCTGAAGAGAAGGCGCGGGAGGCAGAGAGCAAAGCTCGGACATTAGAAGTACGCCTAGGTGGAGACCTCACGCGGGACTC
CAGGGTGATGTTGCGACAGGTCCAGAACAGAGCCATCACTCTGCGCAGAGAAGCCGATGTCAAGAAGAGGATCAAGGAGGCCAAGCAGCG
AGCACTTAAAGAACCTAAGGAACTGAATTTTGTTTTTGGTGTCAACATTGAACACCGGGATCTGGATGGCATGTTCATCTACAACTGTAG
CCGACTGATCAAAATGTATGAGAAAGTGGGCCCACAGCTGGAAGGGGGCATGGCATGTGGCGGGGTTGTTGGGGTTGTTGATGTGCCCTA
CCTGGTCCTGGAGCCTACACACAACAAACAGGACTTTGCTGATGCCAAGGAGTACCGGCACCTGCTCCGAGCAATGGGGGAGCACCTGGC
GCAGTATTGGAAGGATATTGCCATCGCCCAGAGGGGAATCATCAAGTTCTGGGATGAGTTTGGCTACCTCTCTGCCAACTGGAACCAGCC
CCCATCCAGTGAGCTGCGTTACAAACGCCGGAGAGCTATGGAAATCCCCACCACCATCCAGTGCGATTTGTGTCTGAAATGGAGAACCCT
CCCCTTCCAGCTGAGTTCTGTGGAAAAAGATTACCCTGACACCTGGGTTTGCTCCATGAACCCTGATCCTGAACAGGACCGGTGTGAGGC
TTCTGAACAAAAGCAGAAGGTTCCCCTGGGAACATTCAGAAAGGACATGAAGACGCAGGAAGAGAAGCAGAAACAACTGACAGAGAAAAT
TCGCCAGCAGCAGGAGAAGCTGGAGGCCCTTCAGAAAACCACACCCATCCGCTCCCAAGCAGACCTGAAGAAATTGCCCTTGGAAGTGAC
CACCAGACCTTCCACTGAGGAACCTGTGCGTAGACCTCAGCGTCCTCGGTCGCCCCCTTTACCTGCTGTGATCAGGAACGCCCCCAGCAG
ACCCCCTTCTTTGCCAACTCCTAGACCAGCCAGCCAGCCCCGAAAGGCTCCTGTCATCAGCAGTACCCCAAAGCTCCCTGCTTTGGCAGC
CCGGGAGGAGGCCAGCACATCTAGGCTGCTCCAGCCACCTGAGGCACCCCGAAAGCCTGCCAACACTCTCGTCAAGACTGCATCCCGACC
TGCCCCTCTGGTGCAGCAACTGTCACCATCTTTACTGCCCAACTCCAAGAGCCCTCGGGAGGTTCCTTCTCCCAAAGTCATCAAGACTCC
AGTGGTGAAGAAGACAGAGTCACCCATCAAACTCTCCCCGGCTACCCCTAGTCGGAAGCGGAGTGTCGCAGTTTCTGATGAGGAAGAAGT
TGAGGAGGAAGCTGAGAGGAGGAAGGAGAGGTGCAAGCGGGGCAGATTTGTTGTGAAGGAGGAAAAGAAGGACTCGAATGAGCTCTCAGA
CAGTGCTGGGGAAGAGGACTCGGCTGACCTCAAGAGAGCTCAGAAAGATAAAGGGCTGCACGTGGAGGTGCGTGTGAACAGGGAGTGGTA
CACGGGCCGTGTCACAGCCGTGGAGGTGGGCAAGCATGTGGTGCGGTGGAAGGTGAAGTTTGACTACGTGCCCACAGACACGACACCAAG
AGACCGCTGGGTGGAGAAAGGCAGTGAGGATGTGCGGCTGATGAAACCCCCTTCTCCGGAACATCAGAGCCTTGATACACAACAGGAGGG
CGGGGAGGAGGAGGTGGGCCCTGTGGCCCAGCAGGCCATAGCTGTCGCAGAGCCCTCCACTTCCGAATGCCTCCGCATTGAGCCTGACAC
CACTGCCCTGAGCACCAATCACGAGACCATCGACCTGCTTGTCCAGATCCTCCGGAATTGTTTACGGTACTTCCTGCCTCCAAGTTTCCC
CATCTCCAAGAAGCAGCTGAGTGCTATGAATTCAGATGAGCTAATATCTTTTCCTCTGAAGGAGTACTTCAAGCAATATGAAGTAGGGCT
CCAAAACCTGTGCAATTCCTACCAGAGCCGTGCTGACTCCCGGGCCAAGGCCTCCGAGGAAAGCCTGCGCACCTCCGAGAGGAAGCTCCG
CGAGACGGAGGAGAAGCTGCAGAAGCTGAGGACCAACATCGTGGCACTCCTGCAAAAGGTGCAGGAGGACATAGACATCAACACAGATGA
TGAGCTGGACGCCTACATTGAGGACCTCATCACCAAGGGGGACTGAAGGCAGGAGAGAGAGCAGCTCCCCTGCCCACCTGCCCCTCAACC
CTGTAGCTGCAGGGGGAGGGGACTTCATTCATGGGTTGGTGGTCGCACCTTGGTTTGACTTACACGGGACATTTGTGTTTTTGGAGGAAA
AGATACCCTGATTCTTTGAATCTTCCTTAAGTTTATAAATATTTATTTTTTAAAAGAAGATGCTGTGCCTGTGAGACCATACTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTGGTGACTGCAAAGGACAGAGAACCTTTCCACTTTGGCCATACTGGGTTGCTAAGCCGGAGCC
ATTTCAGCTCCTGGCTCCTCAAGATAACGGCGAGTCCAGTGCCATCTTGGAGAAGCTCCAGGGGCAGGGCTGACTTTTCTCCTACAGGAG
GAACAATGTGGGGATCTGAGGGATGGGAGGGAGACTTCCCCCTAGAGTGGTGGTCCTGCTGGGGGCTCATATCCAGGGACCCAAAAGGGG
GGCTGTGTAGGAGGTTCCACATTGGAGGGGCTCTCTCTCTCGCAGCTGTCAGAGTTGGTCCTGGCTGTGGCGTCCAAACAGCTTGAGGGA
AAAAGATCCTGTCTAACCACCTCATCTACTACTCAAGTTCTTTCTGAAGGAGGGATTTCTTCAGTTAACCATGGACAGTGAGGTTTCTCA
CCACAGTAACTTGAGTCCAGGTTGAGGGGGAGACAGATCTGTGGTAAATCTCTGACTTGGGCAGCACACTGAGTGTGGAACCCCACAGGA
CTCCTTAGGGAAGGAGCTTGTGTGTGAAAGAACCCCTGGGGCTGAGCTGGTGACCTCCATGTGTGGGTGCAGCAGGGCCTTGGATGGTGC
CAATTGATCTGGACAGCCTGTTGATGCTTTTCTACTTCCACCCTTCGGCCTGGCCCCACTGAGCCCCATCAAGGTGCCTGAAGAGGGGGC
CAGTGAGATCCCGTGGCCACAGGGACTCCAGAGGCATCTCTGCAGGAAGCACACCATGCCTTCCCTCCATGTTCCATCACGGCGCCACAA
TCTGTGTCCCTTAACTTCTCAGGGTCAAAGACAAAGGCAAGCGTTGCTGAATTTTCTCTTTAATGGCCATTGGAAGAGTCTGGTTCAGTT
TTTCCCAACTCTCTTCCCACTCGTATTTGGGGCCTCTGGGTTTTCTGAAGGCACAAGGACTGTGACTTTGTACCACTAACCTGTGGTTCA
AACCTGGGTGTGTTTCTGGCATCTCCCTAACCCAGATCAGCAATGGCCACCCTGCTCCTCTGAGGTCAGCAGAAGACTGGGAAGCAGAGG
TGAGGGATGCAGGCCACACTGGAATGGGAAGTCTTTTCCCCACTGGATGTGCCTGTCTGGTGGGTTTTGGACCTTCCCAGACTACATCTC
TAGGAGAGGCCTGTTTGGAGTAGTACACTGAGAGACCCTGGCCTCTTCTGCTGGAAGACTGTCCAAGTCTTGGGGTTTCTTGAGCTGGTG
ATTCCTCTGCCATCCTGCTCTCTCTCTTCATCTCAGGCAGCATGGGGTCCACTTTTGTCCCCAAACCTAATGTTTTAATCCAAATGCAAA
TTGGTTCCACATTTTTACTGGAGGGTAATCAGTTTTTAAAATTCACACACATGTAATCGAAACGCAATACTATAAAGTTCTACTGGTGAG

>66604_66604_3_PMEL-MORC2_PMEL_chr12_56359720_ENST00000539511_MORC2_chr22_31346431_ENST00000397641_length(amino acids)=1027AA_BP=47
MIPPQGPIPVPPVPLVAGGKNTMDLVLKRCLLHLAVIGALLAVGATKERREDLRGGFMLCFLDDGAGMDPSDAASVIQFGKSAKRTPEST
QIGQYGNGLKSGSMRIGKDFILFTKKEDTMTCLFLSRTFHEEEGIDEVIVPLPTWNARTREPVTDNVEKFAIETELIYKYSPFRTEEEVM
TQFMKIPGDSGTLVIIFNLKLMDNGEPELDIISNPRDIQMAETSPEGTKPERRSFRAYAAVLYIDPRMRIFIHGHKVQTKRLSCCLYKPR
MYKYTSSRFKTRAEQEVKKAEHVARIAEEKAREAESKARTLEVRLGGDLTRDSRVMLRQVQNRAITLRREADVKKRIKEAKQRALKEPKE
LNFVFGVNIEHRDLDGMFIYNCSRLIKMYEKVGPQLEGGMACGGVVGVVDVPYLVLEPTHNKQDFADAKEYRHLLRAMGEHLAQYWKDIA
IAQRGIIKFWDEFGYLSANWNQPPSSELRYKRRRAMEIPTTIQCDLCLKWRTLPFQLSSVEKDYPDTWVCSMNPDPEQDRCEASEQKQKV
PLGTFRKDMKTQEEKQKQLTEKIRQQQEKLEALQKTTPIRSQADLKKLPLEVTTRPSTEEPVRRPQRPRSPPLPAVIRNAPSRPPSLPTP
RPASQPRKAPVISSTPKLPALAAREEASTSRLLQPPEAPRKPANTLVKTASRPAPLVQQLSPSLLPNSKSPREVPSPKVIKTPVVKKTES
PIKLSPATPSRKRSVAVSDEEEVEEEAERRKERCKRGRFVVKEEKKDSNELSDSAGEEDSADLKRAQKDKGLHVEVRVNREWYTGRVTAV
EVGKHVVRWKVKFDYVPTDTTPRDRWVEKGSEDVRLMKPPSPEHQSLDTQQEGGEEEVGPVAQQAIAVAEPSTSECLRIEPDTTALSTNH
ETIDLLVQILRNCLRYFLPPSFPISKKQLSAMNSDELISFPLKEYFKQYEVGLQNLCNSYQSRADSRAKASEESLRTSERKLRETEEKLQ

--------------------------------------------------------------
>66604_66604_4_PMEL-MORC2_PMEL_chr12_56359720_ENST00000548493_MORC2_chr22_31346431_ENST00000397641_length(transcript)=4801nt_BP=186nt
TCAACGTCAGAGCCGGGGGGCGAGCCCAGCGCTCCTCCCCGCAAATGATCCCGCCCCAGGGGCCTATCCCAGTCCCCCCAGTGCCTTTGG
TTGCTGGAGGGAAGAACACAATGGATCTGGTGCTAAAAAGATGCCTTCTTCATTTGGCTGTGATAGGTGCTTTGCTGGCTGTGGGGGCTA
CAAAAGAAAGACGAGAGGACCTTCGAGGAGGATTTATGCTTTGCTTTTTGGATGATGGAGCAGGAATGGATCCAAGTGATGCTGCCAGTG
TGATCCAGTTTGGGAAGTCGGCCAAGCGAACACCTGAGTCTACTCAGATTGGGCAGTACGGGAATGGGTTAAAATCGGGCTCAATGCGCA
TTGGGAAGGATTTTATCCTGTTCACCAAGAAGGAAGACACCATGACCTGCCTCTTCCTGTCTCGCACGTTTCATGAGGAAGAAGGCATTG
ATGAAGTGATAGTCCCACTGCCCACCTGGAATGCTCGGACCCGGGAACCTGTCACAGACAATGTAGAGAAATTTGCCATTGAGACAGAAC
TCATCTATAAGTACTCTCCATTCCGCACTGAGGAGGAAGTGATGACCCAGTTTATGAAGATTCCTGGGGACAGCGGAACATTGGTGATCA
TCTTCAATCTCAAACTCATGGATAATGGAGAGCCAGAACTAGACATAATCTCAAATCCAAGAGATATCCAGATGGCAGAGACGTCCCCAG
AGGGCACGAAGCCAGAGCGGCGCTCGTTCCGTGCCTATGCCGCTGTGCTCTATATTGATCCCCGGATGAGGATCTTCATCCATGGGCACA
AGGTGCAGACCAAGAGGCTCTCCTGCTGCCTGTACAAGCCCAGGATGTACAAGTACACGTCAAGCCGTTTCAAGACCCGTGCGGAGCAGG
AGGTGAAGAAAGCAGAGCACGTAGCAAGGATTGCTGAAGAGAAGGCGCGGGAGGCAGAGAGCAAAGCTCGGACATTAGAAGTACGCCTAG
GTGGAGACCTCACGCGGGACTCCAGGGTGATGTTGCGACAGGTCCAGAACAGAGCCATCACTCTGCGCAGAGAAGCCGATGTCAAGAAGA
GGATCAAGGAGGCCAAGCAGCGAGCACTTAAAGAACCTAAGGAACTGAATTTTGTTTTTGGTGTCAACATTGAACACCGGGATCTGGATG
GCATGTTCATCTACAACTGTAGCCGACTGATCAAAATGTATGAGAAAGTGGGCCCACAGCTGGAAGGGGGCATGGCATGTGGCGGGGTTG
TTGGGGTTGTTGATGTGCCCTACCTGGTCCTGGAGCCTACACACAACAAACAGGACTTTGCTGATGCCAAGGAGTACCGGCACCTGCTCC
GAGCAATGGGGGAGCACCTGGCGCAGTATTGGAAGGATATTGCCATCGCCCAGAGGGGAATCATCAAGTTCTGGGATGAGTTTGGCTACC
TCTCTGCCAACTGGAACCAGCCCCCATCCAGTGAGCTGCGTTACAAACGCCGGAGAGCTATGGAAATCCCCACCACCATCCAGTGCGATT
TGTGTCTGAAATGGAGAACCCTCCCCTTCCAGCTGAGTTCTGTGGAAAAAGATTACCCTGACACCTGGGTTTGCTCCATGAACCCTGATC
CTGAACAGGACCGGTGTGAGGCTTCTGAACAAAAGCAGAAGGTTCCCCTGGGAACATTCAGAAAGGACATGAAGACGCAGGAAGAGAAGC
AGAAACAACTGACAGAGAAAATTCGCCAGCAGCAGGAGAAGCTGGAGGCCCTTCAGAAAACCACACCCATCCGCTCCCAAGCAGACCTGA
AGAAATTGCCCTTGGAAGTGACCACCAGACCTTCCACTGAGGAACCTGTGCGTAGACCTCAGCGTCCTCGGTCGCCCCCTTTACCTGCTG
TGATCAGGAACGCCCCCAGCAGACCCCCTTCTTTGCCAACTCCTAGACCAGCCAGCCAGCCCCGAAAGGCTCCTGTCATCAGCAGTACCC
CAAAGCTCCCTGCTTTGGCAGCCCGGGAGGAGGCCAGCACATCTAGGCTGCTCCAGCCACCTGAGGCACCCCGAAAGCCTGCCAACACTC
TCGTCAAGACTGCATCCCGACCTGCCCCTCTGGTGCAGCAACTGTCACCATCTTTACTGCCCAACTCCAAGAGCCCTCGGGAGGTTCCTT
CTCCCAAAGTCATCAAGACTCCAGTGGTGAAGAAGACAGAGTCACCCATCAAACTCTCCCCGGCTACCCCTAGTCGGAAGCGGAGTGTCG
CAGTTTCTGATGAGGAAGAAGTTGAGGAGGAAGCTGAGAGGAGGAAGGAGAGGTGCAAGCGGGGCAGATTTGTTGTGAAGGAGGAAAAGA
AGGACTCGAATGAGCTCTCAGACAGTGCTGGGGAAGAGGACTCGGCTGACCTCAAGAGAGCTCAGAAAGATAAAGGGCTGCACGTGGAGG
TGCGTGTGAACAGGGAGTGGTACACGGGCCGTGTCACAGCCGTGGAGGTGGGCAAGCATGTGGTGCGGTGGAAGGTGAAGTTTGACTACG
TGCCCACAGACACGACACCAAGAGACCGCTGGGTGGAGAAAGGCAGTGAGGATGTGCGGCTGATGAAACCCCCTTCTCCGGAACATCAGA
GCCTTGATACACAACAGGAGGGCGGGGAGGAGGAGGTGGGCCCTGTGGCCCAGCAGGCCATAGCTGTCGCAGAGCCCTCCACTTCCGAAT
GCCTCCGCATTGAGCCTGACACCACTGCCCTGAGCACCAATCACGAGACCATCGACCTGCTTGTCCAGATCCTCCGGAATTGTTTACGGT
ACTTCCTGCCTCCAAGTTTCCCCATCTCCAAGAAGCAGCTGAGTGCTATGAATTCAGATGAGCTAATATCTTTTCCTCTGAAGGAGTACT
TCAAGCAATATGAAGTAGGGCTCCAAAACCTGTGCAATTCCTACCAGAGCCGTGCTGACTCCCGGGCCAAGGCCTCCGAGGAAAGCCTGC
GCACCTCCGAGAGGAAGCTCCGCGAGACGGAGGAGAAGCTGCAGAAGCTGAGGACCAACATCGTGGCACTCCTGCAAAAGGTGCAGGAGG
ACATAGACATCAACACAGATGATGAGCTGGACGCCTACATTGAGGACCTCATCACCAAGGGGGACTGAAGGCAGGAGAGAGAGCAGCTCC
CCTGCCCACCTGCCCCTCAACCCTGTAGCTGCAGGGGGAGGGGACTTCATTCATGGGTTGGTGGTCGCACCTTGGTTTGACTTACACGGG
ACATTTGTGTTTTTGGAGGAAAAGATACCCTGATTCTTTGAATCTTCCTTAAGTTTATAAATATTTATTTTTTAAAAGAAGATGCTGTGC
CTGTGAGACCATACTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTGGTGACTGCAAAGGACAGAGAACCTTTCCACTTTGGCCAT
ACTGGGTTGCTAAGCCGGAGCCATTTCAGCTCCTGGCTCCTCAAGATAACGGCGAGTCCAGTGCCATCTTGGAGAAGCTCCAGGGGCAGG
GCTGACTTTTCTCCTACAGGAGGAACAATGTGGGGATCTGAGGGATGGGAGGGAGACTTCCCCCTAGAGTGGTGGTCCTGCTGGGGGCTC
ATATCCAGGGACCCAAAAGGGGGGCTGTGTAGGAGGTTCCACATTGGAGGGGCTCTCTCTCTCGCAGCTGTCAGAGTTGGTCCTGGCTGT
GGCGTCCAAACAGCTTGAGGGAAAAAGATCCTGTCTAACCACCTCATCTACTACTCAAGTTCTTTCTGAAGGAGGGATTTCTTCAGTTAA
CCATGGACAGTGAGGTTTCTCACCACAGTAACTTGAGTCCAGGTTGAGGGGGAGACAGATCTGTGGTAAATCTCTGACTTGGGCAGCACA
CTGAGTGTGGAACCCCACAGGACTCCTTAGGGAAGGAGCTTGTGTGTGAAAGAACCCCTGGGGCTGAGCTGGTGACCTCCATGTGTGGGT
GCAGCAGGGCCTTGGATGGTGCCAATTGATCTGGACAGCCTGTTGATGCTTTTCTACTTCCACCCTTCGGCCTGGCCCCACTGAGCCCCA
TCAAGGTGCCTGAAGAGGGGGCCAGTGAGATCCCGTGGCCACAGGGACTCCAGAGGCATCTCTGCAGGAAGCACACCATGCCTTCCCTCC
ATGTTCCATCACGGCGCCACAATCTGTGTCCCTTAACTTCTCAGGGTCAAAGACAAAGGCAAGCGTTGCTGAATTTTCTCTTTAATGGCC
ATTGGAAGAGTCTGGTTCAGTTTTTCCCAACTCTCTTCCCACTCGTATTTGGGGCCTCTGGGTTTTCTGAAGGCACAAGGACTGTGACTT
TGTACCACTAACCTGTGGTTCAAACCTGGGTGTGTTTCTGGCATCTCCCTAACCCAGATCAGCAATGGCCACCCTGCTCCTCTGAGGTCA
GCAGAAGACTGGGAAGCAGAGGTGAGGGATGCAGGCCACACTGGAATGGGAAGTCTTTTCCCCACTGGATGTGCCTGTCTGGTGGGTTTT
GGACCTTCCCAGACTACATCTCTAGGAGAGGCCTGTTTGGAGTAGTACACTGAGAGACCCTGGCCTCTTCTGCTGGAAGACTGTCCAAGT
CTTGGGGTTTCTTGAGCTGGTGATTCCTCTGCCATCCTGCTCTCTCTCTTCATCTCAGGCAGCATGGGGTCCACTTTTGTCCCCAAACCT
AATGTTTTAATCCAAATGCAAATTGGTTCCACATTTTTACTGGAGGGTAATCAGTTTTTAAAATTCACACACATGTAATCGAAACGCAAT

>66604_66604_4_PMEL-MORC2_PMEL_chr12_56359720_ENST00000548493_MORC2_chr22_31346431_ENST00000397641_length(amino acids)=1027AA_BP=47
MIPPQGPIPVPPVPLVAGGKNTMDLVLKRCLLHLAVIGALLAVGATKERREDLRGGFMLCFLDDGAGMDPSDAASVIQFGKSAKRTPEST
QIGQYGNGLKSGSMRIGKDFILFTKKEDTMTCLFLSRTFHEEEGIDEVIVPLPTWNARTREPVTDNVEKFAIETELIYKYSPFRTEEEVM
TQFMKIPGDSGTLVIIFNLKLMDNGEPELDIISNPRDIQMAETSPEGTKPERRSFRAYAAVLYIDPRMRIFIHGHKVQTKRLSCCLYKPR
MYKYTSSRFKTRAEQEVKKAEHVARIAEEKAREAESKARTLEVRLGGDLTRDSRVMLRQVQNRAITLRREADVKKRIKEAKQRALKEPKE
LNFVFGVNIEHRDLDGMFIYNCSRLIKMYEKVGPQLEGGMACGGVVGVVDVPYLVLEPTHNKQDFADAKEYRHLLRAMGEHLAQYWKDIA
IAQRGIIKFWDEFGYLSANWNQPPSSELRYKRRRAMEIPTTIQCDLCLKWRTLPFQLSSVEKDYPDTWVCSMNPDPEQDRCEASEQKQKV
PLGTFRKDMKTQEEKQKQLTEKIRQQQEKLEALQKTTPIRSQADLKKLPLEVTTRPSTEEPVRRPQRPRSPPLPAVIRNAPSRPPSLPTP
RPASQPRKAPVISSTPKLPALAAREEASTSRLLQPPEAPRKPANTLVKTASRPAPLVQQLSPSLLPNSKSPREVPSPKVIKTPVVKKTES
PIKLSPATPSRKRSVAVSDEEEVEEEAERRKERCKRGRFVVKEEKKDSNELSDSAGEEDSADLKRAQKDKGLHVEVRVNREWYTGRVTAV
EVGKHVVRWKVKFDYVPTDTTPRDRWVEKGSEDVRLMKPPSPEHQSLDTQQEGGEEEVGPVAQQAIAVAEPSTSECLRIEPDTTALSTNH
ETIDLLVQILRNCLRYFLPPSFPISKKQLSAMNSDELISFPLKEYFKQYEVGLQNLCNSYQSRADSRAKASEESLRTSERKLRETEEKLQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PMEL-MORC2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PMEL-MORC2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PMEL-MORC2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource