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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
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Fusion gene:PMEPA1-PTGIS (FusionGDB2 ID:66620)

Fusion Gene Summary for PMEPA1-PTGIS

Fusion gene summary

Fusion gene information	Fusion gene name: PMEPA1-PTGIS
	Fusion gene ID: 66620
		Hgene	Tgene
	Gene symbol	PMEPA1	PTGIS
	Gene ID	56937	5740
	Gene name	prostate transmembrane protein, androgen induced 1	prostaglandin I2 synthase
	Synonyms	STAG1\|TMEPAI	CYP8\|CYP8A1\|PGIS\|PTGI
	Cytomap	20q13.31	20q13.13
	Type of gene	protein-coding	protein-coding
	Description	protein TMEPAIsolid tumor-associated 1 proteintransmembrane, prostate androgen induced RNA	prostacyclin synthasecytochrome P450, family 8, subfamily A, polypeptide 1prostaglandin I2 (prostacyclin) synthase
	Modification date	20200313	20200327
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000341744, ENST00000265626, ENST00000347215, ENST00000395814, ENST00000395816, ENST00000472841,	ENST00000478971, ENST00000244043,
Fusion gene scores	* DoF score	15 X 12 X 5=900	7 X 6 X 4=168
	# samples	17	8
	** MAII score	log2(17/900*10)=-2.40439025507934 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/168*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: PMEPA1 [Title/Abstract] AND PTGIS [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	PMEPA1(56284530)-PTGIS(48130932), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PMEPA1	GO:0010991	negative regulation of SMAD protein complex assembly	20129061
Hgene	PMEPA1	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	24627487
Hgene	PMEPA1	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation	24627487
Tgene	PTGIS	GO:0001516	prostaglandin biosynthetic process	20122998\|21296955
Tgene	PTGIS	GO:0032088	negative regulation of NF-kappaB transcription factor activity	20159982
Tgene	PTGIS	GO:0035360	positive regulation of peroxisome proliferator activated receptor signaling pathway	11551955
Tgene	PTGIS	GO:0045019	negative regulation of nitric oxide biosynthetic process	20159982
Tgene	PTGIS	GO:0050728	negative regulation of inflammatory response	20159982
Tgene	PTGIS	GO:0071456	cellular response to hypoxia	21296955
Tgene	PTGIS	GO:0097190	apoptotic signaling pathway	11551955
Tgene	PTGIS	GO:1900119	positive regulation of execution phase of apoptosis	11551955

Fusion gene breakpoints across PMEPA1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PTGIS (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-AR-A0TX-01A	PMEPA1	chr20	56284530	-	PTGIS	chr20	48130932	-
ChimerDB4	BRCA	TCGA-AR-A0TX	PMEPA1	chr20	56284529	-	PTGIS	chr20	48130932	-

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Fusion Gene ORF analysis for PMEPA1-PTGIS

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000341744	ENST00000478971	PMEPA1	chr20	56284530	-	PTGIS	chr20	48130932	-
5CDS-5UTR	ENST00000341744	ENST00000478971	PMEPA1	chr20	56284529	-	PTGIS	chr20	48130932	-
In-frame	ENST00000341744	ENST00000244043	PMEPA1	chr20	56284530	-	PTGIS	chr20	48130932	-
In-frame	ENST00000341744	ENST00000244043	PMEPA1	chr20	56284529	-	PTGIS	chr20	48130932	-
intron-3CDS	ENST00000265626	ENST00000244043	PMEPA1	chr20	56284530	-	PTGIS	chr20	48130932	-
intron-3CDS	ENST00000265626	ENST00000244043	PMEPA1	chr20	56284529	-	PTGIS	chr20	48130932	-
intron-3CDS	ENST00000347215	ENST00000244043	PMEPA1	chr20	56284530	-	PTGIS	chr20	48130932	-
intron-3CDS	ENST00000347215	ENST00000244043	PMEPA1	chr20	56284529	-	PTGIS	chr20	48130932	-
intron-3CDS	ENST00000395814	ENST00000244043	PMEPA1	chr20	56284530	-	PTGIS	chr20	48130932	-
intron-3CDS	ENST00000395814	ENST00000244043	PMEPA1	chr20	56284529	-	PTGIS	chr20	48130932	-
intron-3CDS	ENST00000395816	ENST00000244043	PMEPA1	chr20	56284530	-	PTGIS	chr20	48130932	-
intron-3CDS	ENST00000395816	ENST00000244043	PMEPA1	chr20	56284529	-	PTGIS	chr20	48130932	-
intron-3CDS	ENST00000472841	ENST00000244043	PMEPA1	chr20	56284530	-	PTGIS	chr20	48130932	-
intron-3CDS	ENST00000472841	ENST00000244043	PMEPA1	chr20	56284529	-	PTGIS	chr20	48130932	-
intron-5UTR	ENST00000265626	ENST00000478971	PMEPA1	chr20	56284530	-	PTGIS	chr20	48130932	-
intron-5UTR	ENST00000265626	ENST00000478971	PMEPA1	chr20	56284529	-	PTGIS	chr20	48130932	-
intron-5UTR	ENST00000347215	ENST00000478971	PMEPA1	chr20	56284530	-	PTGIS	chr20	48130932	-
intron-5UTR	ENST00000347215	ENST00000478971	PMEPA1	chr20	56284529	-	PTGIS	chr20	48130932	-
intron-5UTR	ENST00000395814	ENST00000478971	PMEPA1	chr20	56284530	-	PTGIS	chr20	48130932	-
intron-5UTR	ENST00000395814	ENST00000478971	PMEPA1	chr20	56284529	-	PTGIS	chr20	48130932	-
intron-5UTR	ENST00000395816	ENST00000478971	PMEPA1	chr20	56284530	-	PTGIS	chr20	48130932	-
intron-5UTR	ENST00000395816	ENST00000478971	PMEPA1	chr20	56284529	-	PTGIS	chr20	48130932	-
intron-5UTR	ENST00000472841	ENST00000478971	PMEPA1	chr20	56284530	-	PTGIS	chr20	48130932	-
intron-5UTR	ENST00000472841	ENST00000478971	PMEPA1	chr20	56284529	-	PTGIS	chr20	48130932	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000341744	PMEPA1	chr20	56284530	-	ENST00000244043	PTGIS	chr20	48130932	-	5123	429	375	1076	233
ENST00000341744	PMEPA1	chr20	56284529	-	ENST00000244043	PTGIS	chr20	48130932	-	5123	429	375	1076	233

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000341744	ENST00000244043	PMEPA1	chr20	56284530	-	PTGIS	chr20	48130932	-	0.003579099	0.996421
ENST00000341744	ENST00000244043	PMEPA1	chr20	56284529	-	PTGIS	chr20	48130932	-	0.003579099	0.996421

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Fusion Genomic Features for PMEPA1-PTGIS

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PMEPA1-PTGIS

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:56284530/chr20:48130932)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

PTGIS

chr20:56284529

chr20:48130932

ENST00000244043

358_359

285

501.0

Region

Substrate binding

Tgene

PTGIS

chr20:56284530

chr20:48130932

ENST00000244043

358_359

285

501.0

Region

Substrate binding

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PMEPA1

chr20:56284529

chr20:48130932

ENST00000265626

158_161

238.0

Motif

Note=PPxY motif 1

Hgene

PMEPA1

chr20:56284529

chr20:48130932

ENST00000265626

229_232

238.0

Motif

Note=PPxY motif 2

Hgene

PMEPA1

chr20:56284529

chr20:48130932

ENST00000341744

158_161

288.0

Motif

Note=PPxY motif 1

Hgene

PMEPA1

chr20:56284529

chr20:48130932

ENST00000341744

229_232

288.0

Motif

Note=PPxY motif 2

Hgene

PMEPA1

chr20:56284529

chr20:48130932

ENST00000347215

158_161

253.0

Motif

Note=PPxY motif 1

Hgene

PMEPA1

chr20:56284529

chr20:48130932

ENST00000347215

229_232

253.0

Motif

Note=PPxY motif 2

Hgene

PMEPA1

chr20:56284529

chr20:48130932

ENST00000395814

158_161

238.0

Motif

Note=PPxY motif 1

Hgene

PMEPA1

chr20:56284529

chr20:48130932

ENST00000395814

229_232

238.0

Motif

Note=PPxY motif 2

Hgene

PMEPA1

chr20:56284529

chr20:48130932

ENST00000395816

158_161

238.0

Motif

Note=PPxY motif 1

Hgene

PMEPA1

chr20:56284529

chr20:48130932

ENST00000395816

229_232

238.0

Motif

Note=PPxY motif 2

Hgene

PMEPA1

chr20:56284530

chr20:48130932

ENST00000265626

158_161

238.0

Motif

Note=PPxY motif 1

Hgene

PMEPA1

chr20:56284530

chr20:48130932

ENST00000265626

229_232

238.0

Motif

Note=PPxY motif 2

Hgene

PMEPA1

chr20:56284530

chr20:48130932

ENST00000341744

158_161

288.0

Motif

Note=PPxY motif 1

Hgene

PMEPA1

chr20:56284530

chr20:48130932

ENST00000341744

229_232

288.0

Motif

Note=PPxY motif 2

Hgene

PMEPA1

chr20:56284530

chr20:48130932

ENST00000347215

158_161

253.0

Motif

Note=PPxY motif 1

Hgene

PMEPA1

chr20:56284530

chr20:48130932

ENST00000347215

229_232

253.0

Motif

Note=PPxY motif 2

Hgene

PMEPA1

chr20:56284530

chr20:48130932

ENST00000395814

158_161

238.0

Motif

Note=PPxY motif 1

Hgene

PMEPA1

chr20:56284530

chr20:48130932

ENST00000395814

229_232

238.0

Motif

Note=PPxY motif 2

Hgene

PMEPA1

chr20:56284530

chr20:48130932

ENST00000395816

158_161

238.0

Motif

Note=PPxY motif 1

Hgene

PMEPA1

chr20:56284530

chr20:48130932

ENST00000395816

229_232

238.0

Motif

Note=PPxY motif 2

Hgene

PMEPA1

chr20:56284529

chr20:48130932

ENST00000265626

1_40

238.0

Topological domain

Lumenal

Hgene

PMEPA1

chr20:56284529

chr20:48130932

ENST00000265626

64_287

238.0

Topological domain

Cytoplasmic

Hgene

PMEPA1

chr20:56284529

chr20:48130932

ENST00000341744

1_40

288.0

Topological domain

Lumenal

Hgene

PMEPA1

chr20:56284529

chr20:48130932

ENST00000341744

64_287

288.0

Topological domain

Cytoplasmic

Hgene

PMEPA1

chr20:56284529

chr20:48130932

ENST00000347215

1_40

253.0

Topological domain

Lumenal

Hgene

PMEPA1

chr20:56284529

chr20:48130932

ENST00000347215

64_287

253.0

Topological domain

Cytoplasmic

Hgene

PMEPA1

chr20:56284529

chr20:48130932

ENST00000395814

1_40

238.0

Topological domain

Lumenal

Hgene

PMEPA1

chr20:56284529

chr20:48130932

ENST00000395814

64_287

238.0

Topological domain

Cytoplasmic

Hgene

PMEPA1

chr20:56284529

chr20:48130932

ENST00000395816

1_40

238.0

Topological domain

Lumenal

Hgene

PMEPA1

chr20:56284529

chr20:48130932

ENST00000395816

64_287

238.0

Topological domain

Cytoplasmic

Hgene

PMEPA1

chr20:56284530

chr20:48130932

ENST00000265626

1_40

238.0

Topological domain

Lumenal

Hgene

PMEPA1

chr20:56284530

chr20:48130932

ENST00000265626

64_287

238.0

Topological domain

Cytoplasmic

Hgene

PMEPA1

chr20:56284530

chr20:48130932

ENST00000341744

1_40

288.0

Topological domain

Lumenal

Hgene

PMEPA1

chr20:56284530

chr20:48130932

ENST00000341744

64_287

288.0

Topological domain

Cytoplasmic

Hgene

PMEPA1

chr20:56284530

chr20:48130932

ENST00000347215

1_40

253.0

Topological domain

Lumenal

Hgene

PMEPA1

chr20:56284530

chr20:48130932

ENST00000347215

64_287

253.0

Topological domain

Cytoplasmic

Hgene

PMEPA1

chr20:56284530

chr20:48130932

ENST00000395814

1_40

238.0

Topological domain

Lumenal

Hgene

PMEPA1

chr20:56284530

chr20:48130932

ENST00000395814

64_287

238.0

Topological domain

Cytoplasmic

Hgene

PMEPA1

chr20:56284530

chr20:48130932

ENST00000395816

1_40

238.0

Topological domain

Lumenal

Hgene

PMEPA1

chr20:56284530

chr20:48130932

ENST00000395816

64_287

238.0

Topological domain

Cytoplasmic

Hgene

PMEPA1

chr20:56284529

chr20:48130932

ENST00000265626

41_63

238.0

Transmembrane

Helical

Hgene

PMEPA1

chr20:56284529

chr20:48130932

ENST00000341744

41_63

288.0

Transmembrane

Helical

Hgene

PMEPA1

chr20:56284529

chr20:48130932

ENST00000347215

41_63

253.0

Transmembrane

Helical

Hgene

PMEPA1

chr20:56284529

chr20:48130932

ENST00000395814

41_63

238.0

Transmembrane

Helical

Hgene

PMEPA1

chr20:56284529

chr20:48130932

ENST00000395816

41_63

238.0

Transmembrane

Helical

Hgene

PMEPA1

chr20:56284530

chr20:48130932

ENST00000265626

41_63

238.0

Transmembrane

Helical

Hgene

PMEPA1

chr20:56284530

chr20:48130932

ENST00000341744

41_63

288.0

Transmembrane

Helical

Hgene

PMEPA1

chr20:56284530

chr20:48130932

ENST00000347215

41_63

253.0

Transmembrane

Helical

Hgene

PMEPA1

chr20:56284530

chr20:48130932

ENST00000395814

41_63

238.0

Transmembrane

Helical

Hgene

PMEPA1

chr20:56284530

chr20:48130932

ENST00000395816

41_63

238.0

Transmembrane

Helical

Tgene

PTGIS

chr20:56284529

chr20:48130932

ENST00000244043

1_20

285

501.0

Transmembrane

Helical

Tgene

PTGIS

chr20:56284530

chr20:48130932

ENST00000244043

1_20

285

501.0

Transmembrane

Helical

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Fusion Gene Sequence for PMEPA1-PTGIS

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>66620_66620_1_PMEPA1-PTGIS_PMEPA1_chr20_56284529_ENST00000341744_PTGIS_chr20_48130932_ENST00000244043_length(transcript)=5123nt_BP=429nt
GGAAAGCTAGCGGCAGAGGCTCAGCCCCGGCGGCAGCGCGCGCCCCGCTGCCAGCCCATTTTCCGGACGCCACCCGCGGGCACTGCCGAC
GCCCCCGGGGCTGCCGAGGGGAGGCCGGGGGGGCGCAGCGGAGCGCGGTCCCGCGCACTGAGCCCCGCGGCGCCCCGGGAACTTGGCGGC
GACCCGAGCCCGGCGAGCCGGGGCGCGCCTCCCCCGCCGCGCGCCTCCTGCATGCGGGGCCCCAGCTCCGGGCGCCGGCCGGAGCCCCCC
CCGGCCGCCCCCGAGCCCCCCGCGCCCCGCGCCGCGCCGCCGCGCCGTCCATGCACCGCTTGATGGGGGTCAACAGCACCGCCGCCGCCG
CCGCCGGGCAGCCCAATGTCTCCTGCACGTGCAACTGCAAACGCTCTTTGTTCCAGAGCATGGAGATCAGGGAATATGGGTCCCGCTGCC
TTCTGGCTCCTGCTCTTCCTTCTCAAGAATCCTGAAGCCCTGGCTGCTGTCCGCGGAGAGCTCGAGAGTATCCTTTGGCAAGCGGAGCAG
CCTGTCTCGCAGACGACCACTCTCCCACAGAAGGTTCTAGACAGCACACCTGTGCTTGATAGCGTGCTGAGTGAGAGCCTCAGGCTTACA
GCTGCCCCCTTCATCACCCGCGAGGTTGTGGTGGACCTGGCCATGCCCATGGCAGACGGGCGAGAATTCAACCTGCGACGTGGTGACCGC
CTCCTCCTCTTCCCCTTCCTGAGCCCCCAGAGAGACCCAGAAATCTACACAGACCCAGAGGTATTTAAATACAACCGATTCCTGAACCCT
GACGGATCAGAGAAGAAAGACTTTTACAAGGATGGGAAACGGCTGAAGAATTACAACATGCCCTGGGGGGCGGGGCACAATCACTGCCTG
GGGAGGAGTTATGCGGTCAACAGCATCAAACAATTTGTGTTCCTTGTGCTGGTGCACTTGGACTTGGAGCTGATCAACGCAGATGTGGAG
ATCCCTGAGTTTGACCTCAGCAGGTACGGCTTCGGTCTGATGCAGCCGGAACACGACGTGCCCGTCCGCTACCGCATCCGCCCATGACAC
AGGGAGCAGATGGATCCACGTGCTCGCCTCTGCCCAGCCTGCCCCAGCCTGCCCCAGCCTCCCAGCTTTCTGTGTGCACAGTTGGCCCGG
GTGCAGGTGCTAGCATTACCACTTCCCTGCTTTTCTCCCAGAAGGCTGGGTCCAGGGGAGGGAAAAGCTAAGAGGGTGAACAAAGAAAAG
ACATTGAAAGCTCTATGGATTATCCACTGCAAAGTTTTCTTTCCAAAATCAGGCTTTGTCTGCTCCCAATTCACCTCGTTACTCTCACCT
CGTGATATCCACAAATGCTATTCAGATAAGGCAGAACTAGGAGTCTTCACTGCTCTGCCCCCAACTCCCGGAGGTGTCACCTTCCTAGTT
CTTATGAGCTAGCATGGCCCGGGCCTTATCCAGTCAAAGCGGATGCTGGCCACAGAAAGGCCACTCAGGATGTCCTTTGTGTCCATTGAT
GTCATTCAGCAGTCAGTCCCCCAATAATCCTTAAACTAGCTAAAACCAAAGGAGTCCCTTAGAAGATCTGCTTCCCTGGGGCCCCATTTG
CCAGATTGCCCCATTGCTCACACTACTTGAGAAAATGCAGGAGAGCTTCCCCCAAGGCTGATGCATTCCCGGTGCAGAACAGGGGCACCC
TCCAAACACTGGGCTCTGAGGAGTGGAGTTCTCTGTTCTAGAGTGACAGGCACCAGATGGGATGGGCTTTCTCAGTGTCAGCACTCAGGT
AGGGAGCTAAGGAAGACACAGCCCAGACAAGATGGCTGGAAGGAGCCAGCCAGGACTCCTTAGACTGATCAAGCCAAAAAAGAAGGTGCC
GATTTCATGCATTCTAGTGCAGAAGCCCCAACTGTGATCACGATCCAGTCTGCAGACGTGTTTTGTTTGGACTTCACTTAAAAAAATGCC
TTAGTTGTTATCATCTTTGGGAGAGTTCATTCAAAATGTCCAGCTTCTCTTGAAAACTTGGTATATCTGGCCACACTGGGCTCACATTCC
CAAGGGTAACTCTTGGCCAGAGCTGAGTGGCAGCCGCCTCCCTTATGCAGGACATGTGCTCTCGGCTTCACCAGGGTTCTGACCGGGTCT
GCTTCTGCATTCACAGCGCCTCCTGGACCTGAAGGCATCTGAGTGTGAGACCCTGTTCTAACTCTTAGAAGTGACATTGTAAGAGGTGGT
GGGGACCAGCTAATTGGTCCAACCCAGCCTGAGTGCACCACCCTTTGAACAAATGTATCAGTGATGAAAATTTGCCTTTGCCCCGGCTTG
CCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGCGGATCACTTGAGGTCGGGAGTTCAAGACCAGCCTGGCCAACATGGCGAAACCCC
GTCTCTACTAAACATAAAAAAATTAGTCAGGTGTGGCGGTGCGTGCCTGTAATCCCAGCTATTCAGGAGGCTGAGGCACCAGAATTGCTT
GAACCCAGGAGGTGGAGGTTGCAGTGAACTGAGACTGCGCCACGGCACTCCAGCCTGGGCGACAGAGCAAGACTCTGTCTCAATAAATAA
ATAATTAATTAAAATAAAAAACAGCTTAAAGAGAAAAATGGCCTGCAAACCTTTTTTATGATGCTATTTTTATTAATATAAAGTCCTGTT
TATTGAGACCCTTTAAATGCCTGCGAGAGACCCTACAGACAGTATGTCTACTCCTCACAGCATCTCTATGAAGAGAAGGAGGGTTGTGCC
CACTTCATAGATGAGAAAACTGAGAGGTGAGGTGACTTGCCTGGGGCCACATAGCTCATAAGCTGTAGAACTCTGCAGGCAGATTTACTG
TCCCAGGAGCAAATGCTGGATGAGCAACTCCTGTTCTTTGGGCTCAAGGGGACTGGTGATGGGACAATTCTTCTCGACTTCAGGAGCTGA
CAGAGCCAGAGGCACCTAAACTTGGGTACATCTTGTAAGACACATAATGAGGTCCCTCTAGCTTTAGCTGGAGGGAGATAAAAGAACCCC
AGACCTCTGAATGTCCCAGAGGCTAGTCTCTTCTCAGAGCAGCACTGGGGTTTGGGGGCTTCCCTGGGCCTCAGCCTCCAGGCACCCCCA
GGATTCCCAGAGAGACGCTGTGATTGGCAGGAGGCAGGATATCCCCAGGGAAACCCATCTTCACGCCTGGGTGACCCCCACTGCCGCCTC
CTTCTTAACTCTGCAGGAAATCAGAGCTGGCAGCCTCCAGTGGGAGGACAGAGCCGGTTTCCGTGGCAACCCTCAGCTGCCTCATCGTGG
CTGGGAAGGGAAGGAAGCAAGCCGGCAGAAATAGCTATGGAAGGTCTTGCGCAGGCTGCAACCCTGGTGTGCTGGGCGAAAACCCTTATG
ACTCCCCCCTTCCAAATCAGGCTGGGTTGTCACTGAGACTAGATTCTCACCTGCCTTCAAAGAAGGGCCAATTCCCTTTAAAGGTCGCAC
CTCCTTGGAACCACAGTCATTAGTGAATTACACTCAAGGAAAAGATGTGCTCCCACCAGGCAGCTCCAGCTGTTACCTGAGATACTGAAG
TGCAGCTCAGGAGACGATTATTTAAACCTGCCCTTGTTTTAATCGTTATTTTTCTCTTTAAAAAAAATAGAAGCTATAAAGAAAAGAGGG
AGAGATGAGTGGGTTAGCTACCTGCTATGCGCTAGTTAGGAAGTTACCTGGATGCCATTGTATTTCTTCATCCCTTGCTTAAGAATCAAA
ATTACTGGACATATGTTAGGAATACTCTTTCTTTCTTTCTTTCTTTTTAAGCTCAGTGGCAAGAATGAAATACTCTTTTTTTTTTTTTTT
TTTTGAGATGGAGTCTCGCTCTGCTGCCCAGGCTAGAGTGCAGTGGCGTGATCTCGGCTCACTGCAAGCTCTGCCTCCCGTGTTCACACC
ATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCACCCGCCACCACACCCGGCTAATTTTTGGATTTTTAGTAGAGATGGGAT
TTCACCGTATTAGCCAGGATGGTCTTGATCTCCTGAGCTCGTGATCTGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGC
CACCGCGCCCAGCCAAGAATAAAATACTCTTAAGTTGATCTAATGAAGTGTTTCCTTACCATTGTGATTATTGTTACTATTATTTGCTAT
ATTTTAATATTGTTGTTTACCAAATATTCTCCTTTAAACAGACTCGCTTTTTAAACTTTTTTTTTTTTTTTTGAGACGGAGTTTCACGCT
TATTGCCCAGGCTGGAGTGCAATGGCACGATCTCAGCTCACCACAACCTCCACCTCCTGGGTTTAAGCAATGCTTCTGCCTCAGCTTCCC
AAGTAGCTGAGATTACAGGCGCACACCACCACGCCCAACTGATTTTTGTATTTTTAGTAGAGACGGGGTTTCCCCATGTTGGTCAGGCTG
GTCTCGAACTCCTGACCTCGTGATTTGCCTGCCTGGGCCTCCCAAAGTGCTAGGATTACAGGCATGAGCCACCATGCCCGGCCTAAACTT
TGTTTTTAAAATGAACTTTTTTTCCCCCCAATTGCTGCCAATAGTGGATAACATGTATCACTCACTGCCAAAAATAGAAAGTGACCATGA
AAAATAAATTCGCTGGGGAAGGGGGCTCCATGCTGGTGTGGCCAAGGCTGAGAGCTCTCTCTTCTCTGTTACAAAACGAGATAAGCAAGT
GTTAGAATTGCCTTAAGGCCACACTGGCATCTCCCTGACCTTCTCCAGGGACAGAAGCAGGAGTAAGTTTCTCATCCCATGGGCGACCAG
GGCCATCTCCTCCCACCAGTGGCCCCCACTCACAGGGAGCTGGCAATGCCCTACCTGCCTGTTCTCCAGATGGAGAAACAGGCTCTGAGA
TTTCACAGGTCTTGCCCAAAGTCATTGATTTTGATGATTAAAAAGAATAAACACAGTGTTTCCTGAGTAGCAGTGATTGTTATGCCTTGC

>66620_66620_1_PMEPA1-PTGIS_PMEPA1_chr20_56284529_ENST00000341744_PTGIS_chr20_48130932_ENST00000244043_length(amino acids)=233AA_BP=18
MSPARATANALCSRAWRSGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFI
TREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYA

--------------------------------------------------------------
>66620_66620_2_PMEPA1-PTGIS_PMEPA1_chr20_56284530_ENST00000341744_PTGIS_chr20_48130932_ENST00000244043_length(transcript)=5123nt_BP=429nt
GGAAAGCTAGCGGCAGAGGCTCAGCCCCGGCGGCAGCGCGCGCCCCGCTGCCAGCCCATTTTCCGGACGCCACCCGCGGGCACTGCCGAC
GCCCCCGGGGCTGCCGAGGGGAGGCCGGGGGGGCGCAGCGGAGCGCGGTCCCGCGCACTGAGCCCCGCGGCGCCCCGGGAACTTGGCGGC
GACCCGAGCCCGGCGAGCCGGGGCGCGCCTCCCCCGCCGCGCGCCTCCTGCATGCGGGGCCCCAGCTCCGGGCGCCGGCCGGAGCCCCCC
CCGGCCGCCCCCGAGCCCCCCGCGCCCCGCGCCGCGCCGCCGCGCCGTCCATGCACCGCTTGATGGGGGTCAACAGCACCGCCGCCGCCG
CCGCCGGGCAGCCCAATGTCTCCTGCACGTGCAACTGCAAACGCTCTTTGTTCCAGAGCATGGAGATCAGGGAATATGGGTCCCGCTGCC
TTCTGGCTCCTGCTCTTCCTTCTCAAGAATCCTGAAGCCCTGGCTGCTGTCCGCGGAGAGCTCGAGAGTATCCTTTGGCAAGCGGAGCAG
CCTGTCTCGCAGACGACCACTCTCCCACAGAAGGTTCTAGACAGCACACCTGTGCTTGATAGCGTGCTGAGTGAGAGCCTCAGGCTTACA
GCTGCCCCCTTCATCACCCGCGAGGTTGTGGTGGACCTGGCCATGCCCATGGCAGACGGGCGAGAATTCAACCTGCGACGTGGTGACCGC
CTCCTCCTCTTCCCCTTCCTGAGCCCCCAGAGAGACCCAGAAATCTACACAGACCCAGAGGTATTTAAATACAACCGATTCCTGAACCCT
GACGGATCAGAGAAGAAAGACTTTTACAAGGATGGGAAACGGCTGAAGAATTACAACATGCCCTGGGGGGCGGGGCACAATCACTGCCTG
GGGAGGAGTTATGCGGTCAACAGCATCAAACAATTTGTGTTCCTTGTGCTGGTGCACTTGGACTTGGAGCTGATCAACGCAGATGTGGAG
ATCCCTGAGTTTGACCTCAGCAGGTACGGCTTCGGTCTGATGCAGCCGGAACACGACGTGCCCGTCCGCTACCGCATCCGCCCATGACAC
AGGGAGCAGATGGATCCACGTGCTCGCCTCTGCCCAGCCTGCCCCAGCCTGCCCCAGCCTCCCAGCTTTCTGTGTGCACAGTTGGCCCGG
GTGCAGGTGCTAGCATTACCACTTCCCTGCTTTTCTCCCAGAAGGCTGGGTCCAGGGGAGGGAAAAGCTAAGAGGGTGAACAAAGAAAAG
ACATTGAAAGCTCTATGGATTATCCACTGCAAAGTTTTCTTTCCAAAATCAGGCTTTGTCTGCTCCCAATTCACCTCGTTACTCTCACCT
CGTGATATCCACAAATGCTATTCAGATAAGGCAGAACTAGGAGTCTTCACTGCTCTGCCCCCAACTCCCGGAGGTGTCACCTTCCTAGTT
CTTATGAGCTAGCATGGCCCGGGCCTTATCCAGTCAAAGCGGATGCTGGCCACAGAAAGGCCACTCAGGATGTCCTTTGTGTCCATTGAT
GTCATTCAGCAGTCAGTCCCCCAATAATCCTTAAACTAGCTAAAACCAAAGGAGTCCCTTAGAAGATCTGCTTCCCTGGGGCCCCATTTG
CCAGATTGCCCCATTGCTCACACTACTTGAGAAAATGCAGGAGAGCTTCCCCCAAGGCTGATGCATTCCCGGTGCAGAACAGGGGCACCC
TCCAAACACTGGGCTCTGAGGAGTGGAGTTCTCTGTTCTAGAGTGACAGGCACCAGATGGGATGGGCTTTCTCAGTGTCAGCACTCAGGT
AGGGAGCTAAGGAAGACACAGCCCAGACAAGATGGCTGGAAGGAGCCAGCCAGGACTCCTTAGACTGATCAAGCCAAAAAAGAAGGTGCC
GATTTCATGCATTCTAGTGCAGAAGCCCCAACTGTGATCACGATCCAGTCTGCAGACGTGTTTTGTTTGGACTTCACTTAAAAAAATGCC
TTAGTTGTTATCATCTTTGGGAGAGTTCATTCAAAATGTCCAGCTTCTCTTGAAAACTTGGTATATCTGGCCACACTGGGCTCACATTCC
CAAGGGTAACTCTTGGCCAGAGCTGAGTGGCAGCCGCCTCCCTTATGCAGGACATGTGCTCTCGGCTTCACCAGGGTTCTGACCGGGTCT
GCTTCTGCATTCACAGCGCCTCCTGGACCTGAAGGCATCTGAGTGTGAGACCCTGTTCTAACTCTTAGAAGTGACATTGTAAGAGGTGGT
GGGGACCAGCTAATTGGTCCAACCCAGCCTGAGTGCACCACCCTTTGAACAAATGTATCAGTGATGAAAATTTGCCTTTGCCCCGGCTTG
CCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGCGGATCACTTGAGGTCGGGAGTTCAAGACCAGCCTGGCCAACATGGCGAAACCCC
GTCTCTACTAAACATAAAAAAATTAGTCAGGTGTGGCGGTGCGTGCCTGTAATCCCAGCTATTCAGGAGGCTGAGGCACCAGAATTGCTT
GAACCCAGGAGGTGGAGGTTGCAGTGAACTGAGACTGCGCCACGGCACTCCAGCCTGGGCGACAGAGCAAGACTCTGTCTCAATAAATAA
ATAATTAATTAAAATAAAAAACAGCTTAAAGAGAAAAATGGCCTGCAAACCTTTTTTATGATGCTATTTTTATTAATATAAAGTCCTGTT
TATTGAGACCCTTTAAATGCCTGCGAGAGACCCTACAGACAGTATGTCTACTCCTCACAGCATCTCTATGAAGAGAAGGAGGGTTGTGCC
CACTTCATAGATGAGAAAACTGAGAGGTGAGGTGACTTGCCTGGGGCCACATAGCTCATAAGCTGTAGAACTCTGCAGGCAGATTTACTG
TCCCAGGAGCAAATGCTGGATGAGCAACTCCTGTTCTTTGGGCTCAAGGGGACTGGTGATGGGACAATTCTTCTCGACTTCAGGAGCTGA
CAGAGCCAGAGGCACCTAAACTTGGGTACATCTTGTAAGACACATAATGAGGTCCCTCTAGCTTTAGCTGGAGGGAGATAAAAGAACCCC
AGACCTCTGAATGTCCCAGAGGCTAGTCTCTTCTCAGAGCAGCACTGGGGTTTGGGGGCTTCCCTGGGCCTCAGCCTCCAGGCACCCCCA
GGATTCCCAGAGAGACGCTGTGATTGGCAGGAGGCAGGATATCCCCAGGGAAACCCATCTTCACGCCTGGGTGACCCCCACTGCCGCCTC
CTTCTTAACTCTGCAGGAAATCAGAGCTGGCAGCCTCCAGTGGGAGGACAGAGCCGGTTTCCGTGGCAACCCTCAGCTGCCTCATCGTGG
CTGGGAAGGGAAGGAAGCAAGCCGGCAGAAATAGCTATGGAAGGTCTTGCGCAGGCTGCAACCCTGGTGTGCTGGGCGAAAACCCTTATG
ACTCCCCCCTTCCAAATCAGGCTGGGTTGTCACTGAGACTAGATTCTCACCTGCCTTCAAAGAAGGGCCAATTCCCTTTAAAGGTCGCAC
CTCCTTGGAACCACAGTCATTAGTGAATTACACTCAAGGAAAAGATGTGCTCCCACCAGGCAGCTCCAGCTGTTACCTGAGATACTGAAG
TGCAGCTCAGGAGACGATTATTTAAACCTGCCCTTGTTTTAATCGTTATTTTTCTCTTTAAAAAAAATAGAAGCTATAAAGAAAAGAGGG
AGAGATGAGTGGGTTAGCTACCTGCTATGCGCTAGTTAGGAAGTTACCTGGATGCCATTGTATTTCTTCATCCCTTGCTTAAGAATCAAA
ATTACTGGACATATGTTAGGAATACTCTTTCTTTCTTTCTTTCTTTTTAAGCTCAGTGGCAAGAATGAAATACTCTTTTTTTTTTTTTTT
TTTTGAGATGGAGTCTCGCTCTGCTGCCCAGGCTAGAGTGCAGTGGCGTGATCTCGGCTCACTGCAAGCTCTGCCTCCCGTGTTCACACC
ATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCACCCGCCACCACACCCGGCTAATTTTTGGATTTTTAGTAGAGATGGGAT
TTCACCGTATTAGCCAGGATGGTCTTGATCTCCTGAGCTCGTGATCTGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGC
CACCGCGCCCAGCCAAGAATAAAATACTCTTAAGTTGATCTAATGAAGTGTTTCCTTACCATTGTGATTATTGTTACTATTATTTGCTAT
ATTTTAATATTGTTGTTTACCAAATATTCTCCTTTAAACAGACTCGCTTTTTAAACTTTTTTTTTTTTTTTTGAGACGGAGTTTCACGCT
TATTGCCCAGGCTGGAGTGCAATGGCACGATCTCAGCTCACCACAACCTCCACCTCCTGGGTTTAAGCAATGCTTCTGCCTCAGCTTCCC
AAGTAGCTGAGATTACAGGCGCACACCACCACGCCCAACTGATTTTTGTATTTTTAGTAGAGACGGGGTTTCCCCATGTTGGTCAGGCTG
GTCTCGAACTCCTGACCTCGTGATTTGCCTGCCTGGGCCTCCCAAAGTGCTAGGATTACAGGCATGAGCCACCATGCCCGGCCTAAACTT
TGTTTTTAAAATGAACTTTTTTTCCCCCCAATTGCTGCCAATAGTGGATAACATGTATCACTCACTGCCAAAAATAGAAAGTGACCATGA
AAAATAAATTCGCTGGGGAAGGGGGCTCCATGCTGGTGTGGCCAAGGCTGAGAGCTCTCTCTTCTCTGTTACAAAACGAGATAAGCAAGT
GTTAGAATTGCCTTAAGGCCACACTGGCATCTCCCTGACCTTCTCCAGGGACAGAAGCAGGAGTAAGTTTCTCATCCCATGGGCGACCAG
GGCCATCTCCTCCCACCAGTGGCCCCCACTCACAGGGAGCTGGCAATGCCCTACCTGCCTGTTCTCCAGATGGAGAAACAGGCTCTGAGA
TTTCACAGGTCTTGCCCAAAGTCATTGATTTTGATGATTAAAAAGAATAAACACAGTGTTTCCTGAGTAGCAGTGATTGTTATGCCTTGC

>66620_66620_2_PMEPA1-PTGIS_PMEPA1_chr20_56284530_ENST00000341744_PTGIS_chr20_48130932_ENST00000244043_length(amino acids)=233AA_BP=18
MSPARATANALCSRAWRSGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFI
TREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYA

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for PMEPA1-PTGIS

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for PMEPA1-PTGIS

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for PMEPA1-PTGIS

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source