FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:ARMC7-CDR2L (FusionGDB2 ID:6665)

Fusion Gene Summary for ARMC7-CDR2L

check button Fusion gene summary
Fusion gene informationFusion gene name: ARMC7-CDR2L
Fusion gene ID: 6665
HgeneTgene
Gene symbol

ARMC7

CDR2L

Gene ID

79637

30850

Gene namearmadillo repeat containing 7cerebellar degeneration related protein 2 like
Synonyms-HUMPPA
Cytomap

17q25.1

17q25.1

Type of geneprotein-codingprotein-coding
Descriptionarmadillo repeat-containing protein 7cerebellar degeneration-related protein 2-likeparaneoplastic 62 kDa antigenparaneoplastic antigen
Modification date2020032720200313
UniProtAcc.

Q86X02

Ensembl transtripts involved in fusion geneENST00000245543, ENST00000582136, 
ENST00000584947, ENST00000579096, 
ENST00000581078, 		ENST00000337231, 
Fusion gene scores* DoF score9 X 3 X 5=1357 X 4 X 6=168
# samples 98
** MAII scorelog2(9/135*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARMC7 [Title/Abstract] AND CDR2L [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARMC7(73106701)-CDR2L(72995599), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ARMC7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CDR2L (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-R5-A7ZE-01BARMC7chr17

73106701

-CDR2Lchr17

72995599

+
ChimerDB4STADTCGA-R5-A7ZE-01BARMC7chr17

73106701

+CDR2Lchr17

72995599

+


Top

Fusion Gene ORF analysis for ARMC7-CDR2L

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000245543ENST00000337231ARMC7chr17

73106701

+CDR2Lchr17

72995599

+
In-frameENST00000582136ENST00000337231ARMC7chr17

73106701

+CDR2Lchr17

72995599

+
In-frameENST00000584947ENST00000337231ARMC7chr17

73106701

+CDR2Lchr17

72995599

+
intron-3CDSENST00000579096ENST00000337231ARMC7chr17

73106701

+CDR2Lchr17

72995599

+
intron-3CDSENST00000581078ENST00000337231ARMC7chr17

73106701

+CDR2Lchr17

72995599

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000582136ARMC7chr1773106701+ENST00000337231CDR2Lchr1772995599+35915462571864535
ENST00000245543ARMC7chr1773106701+ENST00000337231CDR2Lchr1772995599+35825372481855535
ENST00000584947ARMC7chr1773106701+ENST00000337231CDR2Lchr1772995599+3388343541661535

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000582136ENST00000337231ARMC7chr1773106701+CDR2Lchr1772995599+0.005398610.99460137
ENST00000245543ENST00000337231ARMC7chr1773106701+CDR2Lchr1772995599+0.005438140.99456185
ENST00000584947ENST00000337231ARMC7chr1773106701+CDR2Lchr1772995599+0.0058045680.9941954

Top

Fusion Genomic Features for ARMC7-CDR2L


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ARMC7chr1773106701+CDR2Lchr1772995598+6.86E-181
ARMC7chr1773106701+CDR2Lchr1772995598+6.86E-181

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for ARMC7-CDR2L


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:73106701/chr17:72995599)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CDR2L

Q86X02

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCDR2Lchr17:73106701chr17:72995599ENST0000033723105188_26526466.0Coiled coilOntology_term=ECO:0000255
TgeneCDR2Lchr17:73106701chr17:72995599ENST0000033723105350_37726466.0Coiled coilOntology_term=ECO:0000255
TgeneCDR2Lchr17:73106701chr17:72995599ENST000003372310538_14326466.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARMC7chr17:73106701chr17:72995599ENST00000245543+23100_14078199.0RepeatNote=ARM 2
HgeneARMC7chr17:73106701chr17:72995599ENST00000245543+2357_9978199.0RepeatNote=ARM 1


Top

Fusion Gene Sequence for ARMC7-CDR2L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>6665_6665_1_ARMC7-CDR2L_ARMC7_chr17_73106701_ENST00000245543_CDR2L_chr17_72995599_ENST00000337231_length(transcript)=3582nt_BP=537nt
CGGGGACGGTGCGCCAGTGCCCCCTCCGCGAGCCCCAACCAGTAGACGGTTCCCTGTCTCCCGCGCCCCAATTTCGATTTTCAAACGCAA
CTCCTACAGGATTCTGAGACCCCGTCCCATCTCCCATATCCCATTTCCAGCTGCAAATTACTGCAGAATCTGAACCCAGGAAAGAAACCC
ATTTGCCGACCCCCTCTTCCCTCTCCAGACAGGTGGAGAGCGGGTGAGGGTCTCGCTCGGCTTTCCCCCTGCACCTTTCCCACCCTCCCG
CCCGTCCCTGGGGGTCCTCCGTCACCGCGGCCATGGCCCAGAAGCCGAAGGTGGACCCCCACGTCGGGCGGCTGGGATACCTGCAGGCGC
TGGTCACGGAATTCCAGGAGACCCAAAGCCAAGACGCCAAGGAGCAAGTCCTCGCCAACCTCGCCAACTTCGCTTATGACCCCAGCAACT
ACGAGTATCTGCGGCAGCTGCAGGTCCTGGATTTATTTCTCGATTCGCTGTCGGAGGAGAATGAGACCCTGGTGGAGTTTGCTATTGACT
TGCACCTAGCTGCGGAGCTGGGGAAGACTCTGCTGGAGAGGAACAAGGAGCTGGAGGGGTCCCTGCAGCAGATGTACTCCACCAATGAGG
AACAGGTGCAGGAGATCGAGTACCTAACCAAGCAGCTGGACACGCTGCGGCACGTGAACGAGCAGCACGCCAAAGTCTATGAGCAGCTGG
ACCTGACAGCCCGGGACCTGGAGCTGACCAACCACAGGCTGGTGCTGGAGAGTAAGGCTGCCCAGCAGAAGATCCATGGGCTGACGGAGA
CCATTGAGCGCCTCCAGGCTCAGGTGGAGGAGCTGCAGGCCCAGGTGGAGCAACTGAGAGGCCTGGAACAGCTGCGAGTGCTCCGGGAGA
AGCGGGAACGCAGGCGTACCATCCACACCTTCCCCTGCCTCAAGGAGCTGTGCACCAGCCCCCGGTGCAAGGATGCTTTCCGCCTACACA
GTTCCTCCCTGGAGCTGGGCCCGCGGCCCCTGGAGCAGGAGAACGAGCGGCTGCAGACCCTGGTGGGGGCGCTGCGCTCCCAGGTGAGCC
AGGAGCGGCAGCGCAAGGAGCGGGCGGAGCGCGAGTACACCGCGGTGCTGCAGGAGTACTCGGAGCTGGAGCGCCAGCTGTGCGAGATGG
AGGCCTGTCGCCTGCGTGTGCAGGAGCTGGAGGCCGAGCTGCTGGAGCTGCAGCAGATGAAGCAGGCCAAGACCTACCTACTGGGTCCGG
ACGACCACCTGGCCGAGGCCCTGCTCGCACCCCTCACGCAGGCCCCTGAGGCCGACGATCCCCAGCCCGGCCGCGGGGACGACTTGGGCG
CCCAGGACGGGGTCTCCTCACCGGCAGCCTCTCCAGGCCACGTGGTGCGCAAGAGCTGCAGCGACACTGCGCTCAACGCCATCGTGGCCA
AAGACCCAGCCAGCCGGCACGCGGGCAACCTCACACTGCACGCCAACAGCGTGCGCAAGCGGGGCATGTCCATCCTGCGGGAGGTGGACG
AGCAGTACCACGCGCTGCTGGAGAAGTACGAGGAGCTGCTGAGCAAGTGCCGGCAGCACGGGGCCGGAGTGCGGCACGCCGGCGTGCAGA
CCTCGCGCCCCATCTCCCGGGACAGCTCGTGGAGGGACCTGCGCGGGGGTGAGGAGGGCCAGGGTGAGGTCAAGGCAGGAGAGAAGAGCC
TGAGCCAGCACGTGGAGGCCGTGGACAAGCGGCTGGAACAGAGCCAGCCCGAGTACAAGGCGCTCTTCAAAGAGATCTTCTCCAGGATCC
AGAAGACCAAGGCTGACATCAACGCCACCAAAGTCAAGACGCACAGCAGCAAGTGACCCTTCTCCGGCCTGCAGCCTCCCCCAGGGTGGA
AGCCGTGGGGTCCCTCAGGCCTGGGCGGTGCAGCTTCCAGAGAGCGAGCGCCCTTTAGCGGCCTGCCACCACAGCACGCGGCCTCCTGAT
CCGGAAGCACGCAGCATGTTCCCTGCTGAGCGGAGGCAGCCCACCTGTCCTGCCTCCCAGGAGCCCTTGGCCACCTCGCGCCAGCCCAAA
GGCGCAGCTCTGAGTTCAAAGCCAAATGTCCCCACTACCCCAGGGATCCCCCAGCTCCCCCAGCCCCTGGCTTCCTGACCCTGCGCCTCA
CCCTCAGACTGGTGACCAGGCTTCTGAAAGCCATTCTGGATCAGTTGGCTTTTTTTTTTTTTTTGGTTAAGTTTGTTTTTTCTAAGAGAT
TTGCAATGCAAGGTCTCCTTGACCCCTTGCCACAACTGGAAACACTTGAAAGGGGACCCCAGGGCCAGCTGTTTCAGGGGTTTCCTGGAC
CACCCACTGCTTCTCCCCAACCCTGATGCGCTGACATTCCCTTAGCACCAGCTGTCCCACCTCCAGGGTCCTGACCAGGTCAGAGATGTC
CCCTGCCATGCAGAGCAGGAAGCCTCAGCTGGGCCTGGAGTGTCCCTGCTCCAGCCCTGCCAGGGACAGGTTTCTCCCTGGATACTCTTG
GCCCACCGCAGATCTGTAGCCAGTCAGAGGAGGAGGAGAAGGAGCCCCTCAGCAGAGTGGTGCAGTTTCGCTCAGAGCTTGTCTCCTTGG
CTTCCAACCCCAGAAATGCCTGCTGGGCCTTAAGCTTTCCAGGGGCCGGGGCAGTGGGGAGCCCCCATCCCTTCACACCGCCACCAACTA
ACCAAGCTTGGCCTCTGACTCCCGTCTCTGTGCTTGCCCCCATCTCAGGGACCATGATGTCTCAGTCACTCCACGCTCCCCACAGGCCAA
CCCTGGCACAGGTCATGTCTGCAGCCCCCAGAATGTTCTGGACATGCACCACCAGCCGGTGGTCCCAATGTCCACCCCTGCCTCCCCTTC
ACTGGGGACTGGGGTTTTCGCCCCATGCTGCATCGTGTTGTATTGGGATGGGGCTGAGGAACATGCTCCCTCCCTCCCTCCCATAAAATG
CCTGCTCTTCACCTCCCACCTTTGTGGGGGGCTTTTGAGGACCCAGCTGCGTCAGGAGTTTTGCTTCAAGATGTCAGAAAGTCAAGTTCA
GCTAAGAGACACCCAGGTCCCCAGCTTGCCCTGAGCAGCCCTTCAGGGCTTCTGGTTCCTTCTGCCGCCCTTCCTGAGACCTTAGAAACC
AGAAGAGCCATACAGTCAGTGGAAGGCGGGGGGGCCCTGGCCTCTGCACCGGGATCCCAGTGGGAACCTTCATGCCTTATTTATTTCTAA
TGGGTAAAGGGGTTTTCTTACCAAGCATCCCTGACCTCCTGGAGACACCACCTGCTTTCCGGGCGGCACTGTGATGGGAGCTGGTGGCGA
CTGAGTCCTTCTGTACGTGCAACTGGGAAACTTTTGTCCTTTGAGGCTAGGCAGCTCCCTGCCCTCCGTGTGTGTCTGTTATCTGGGGGA
GAGGAGTGTGGAAGGGTTGGGGGAAGAGCTCCAGCCTGTCTGCTCCCCAGCTCTGTAGTGGCAGACCAGCGTCACCTTTGAAGTATACGT

>6665_6665_1_ARMC7-CDR2L_ARMC7_chr17_73106701_ENST00000245543_CDR2L_chr17_72995599_ENST00000337231_length(amino acids)=535AA_BP=96
MHLSHPPARPWGSSVTAAMAQKPKVDPHVGRLGYLQALVTEFQETQSQDAKEQVLANLANFAYDPSNYEYLRQLQVLDLFLDSLSEENET
LVEFAIDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQEIEYLTKQLDTLRHVNEQHAKVYEQLDLTARDLELTNHRLVLESKAAQQ
KIHGLTETIERLQAQVEELQAQVEQLRGLEQLRVLREKRERRRTIHTFPCLKELCTSPRCKDAFRLHSSSLELGPRPLEQENERLQTLVG
ALRSQVSQERQRKERAEREYTAVLQEYSELERQLCEMEACRLRVQELEAELLELQQMKQAKTYLLGPDDHLAEALLAPLTQAPEADDPQP
GRGDDLGAQDGVSSPAASPGHVVRKSCSDTALNAIVAKDPASRHAGNLTLHANSVRKRGMSILREVDEQYHALLEKYEELLSKCRQHGAG

--------------------------------------------------------------
>6665_6665_2_ARMC7-CDR2L_ARMC7_chr17_73106701_ENST00000582136_CDR2L_chr17_72995599_ENST00000337231_length(transcript)=3591nt_BP=546nt
CCCAGGAGCCGGGGACGGTGCGCCAGTGCCCCCTCCGCGAGCCCCAACCAGTAGACGGTTCCCTGTCTCCCGCGCCCCAATTTCGATTTT
CAAACGCAACTCCTACAGGATTCTGAGACCCCGTCCCATCTCCCATATCCCATTTCCAGCTGCAAATTACTGCAGAATCTGAACCCAGGA
AAGAAACCCATTTGCCGACCCCCTCTTCCCTCTCCAGACAGGTGGAGAGCGGGTGAGGGTCTCGCTCGGCTTTCCCCCTGCACCTTTCCC
ACCCTCCCGCCCGTCCCTGGGGGTCCTCCGTCACCGCGGCCATGGCCCAGAAGCCGAAGGTGGACCCCCACGTCGGGCGGCTGGGATACC
TGCAGGCGCTGGTCACGGAATTCCAGGAGACCCAAAGCCAAGACGCCAAGGAGCAAGTCCTCGCCAACCTCGCCAACTTCGCTTATGACC
CCAGCAACTACGAGTATCTGCGGCAGCTGCAGGTCCTGGATTTATTTCTCGATTCGCTGTCGGAGGAGAATGAGACCCTGGTGGAGTTTG
CTATTGACTTGCACCTAGCTGCGGAGCTGGGGAAGACTCTGCTGGAGAGGAACAAGGAGCTGGAGGGGTCCCTGCAGCAGATGTACTCCA
CCAATGAGGAACAGGTGCAGGAGATCGAGTACCTAACCAAGCAGCTGGACACGCTGCGGCACGTGAACGAGCAGCACGCCAAAGTCTATG
AGCAGCTGGACCTGACAGCCCGGGACCTGGAGCTGACCAACCACAGGCTGGTGCTGGAGAGTAAGGCTGCCCAGCAGAAGATCCATGGGC
TGACGGAGACCATTGAGCGCCTCCAGGCTCAGGTGGAGGAGCTGCAGGCCCAGGTGGAGCAACTGAGAGGCCTGGAACAGCTGCGAGTGC
TCCGGGAGAAGCGGGAACGCAGGCGTACCATCCACACCTTCCCCTGCCTCAAGGAGCTGTGCACCAGCCCCCGGTGCAAGGATGCTTTCC
GCCTACACAGTTCCTCCCTGGAGCTGGGCCCGCGGCCCCTGGAGCAGGAGAACGAGCGGCTGCAGACCCTGGTGGGGGCGCTGCGCTCCC
AGGTGAGCCAGGAGCGGCAGCGCAAGGAGCGGGCGGAGCGCGAGTACACCGCGGTGCTGCAGGAGTACTCGGAGCTGGAGCGCCAGCTGT
GCGAGATGGAGGCCTGTCGCCTGCGTGTGCAGGAGCTGGAGGCCGAGCTGCTGGAGCTGCAGCAGATGAAGCAGGCCAAGACCTACCTAC
TGGGTCCGGACGACCACCTGGCCGAGGCCCTGCTCGCACCCCTCACGCAGGCCCCTGAGGCCGACGATCCCCAGCCCGGCCGCGGGGACG
ACTTGGGCGCCCAGGACGGGGTCTCCTCACCGGCAGCCTCTCCAGGCCACGTGGTGCGCAAGAGCTGCAGCGACACTGCGCTCAACGCCA
TCGTGGCCAAAGACCCAGCCAGCCGGCACGCGGGCAACCTCACACTGCACGCCAACAGCGTGCGCAAGCGGGGCATGTCCATCCTGCGGG
AGGTGGACGAGCAGTACCACGCGCTGCTGGAGAAGTACGAGGAGCTGCTGAGCAAGTGCCGGCAGCACGGGGCCGGAGTGCGGCACGCCG
GCGTGCAGACCTCGCGCCCCATCTCCCGGGACAGCTCGTGGAGGGACCTGCGCGGGGGTGAGGAGGGCCAGGGTGAGGTCAAGGCAGGAG
AGAAGAGCCTGAGCCAGCACGTGGAGGCCGTGGACAAGCGGCTGGAACAGAGCCAGCCCGAGTACAAGGCGCTCTTCAAAGAGATCTTCT
CCAGGATCCAGAAGACCAAGGCTGACATCAACGCCACCAAAGTCAAGACGCACAGCAGCAAGTGACCCTTCTCCGGCCTGCAGCCTCCCC
CAGGGTGGAAGCCGTGGGGTCCCTCAGGCCTGGGCGGTGCAGCTTCCAGAGAGCGAGCGCCCTTTAGCGGCCTGCCACCACAGCACGCGG
CCTCCTGATCCGGAAGCACGCAGCATGTTCCCTGCTGAGCGGAGGCAGCCCACCTGTCCTGCCTCCCAGGAGCCCTTGGCCACCTCGCGC
CAGCCCAAAGGCGCAGCTCTGAGTTCAAAGCCAAATGTCCCCACTACCCCAGGGATCCCCCAGCTCCCCCAGCCCCTGGCTTCCTGACCC
TGCGCCTCACCCTCAGACTGGTGACCAGGCTTCTGAAAGCCATTCTGGATCAGTTGGCTTTTTTTTTTTTTTTGGTTAAGTTTGTTTTTT
CTAAGAGATTTGCAATGCAAGGTCTCCTTGACCCCTTGCCACAACTGGAAACACTTGAAAGGGGACCCCAGGGCCAGCTGTTTCAGGGGT
TTCCTGGACCACCCACTGCTTCTCCCCAACCCTGATGCGCTGACATTCCCTTAGCACCAGCTGTCCCACCTCCAGGGTCCTGACCAGGTC
AGAGATGTCCCCTGCCATGCAGAGCAGGAAGCCTCAGCTGGGCCTGGAGTGTCCCTGCTCCAGCCCTGCCAGGGACAGGTTTCTCCCTGG
ATACTCTTGGCCCACCGCAGATCTGTAGCCAGTCAGAGGAGGAGGAGAAGGAGCCCCTCAGCAGAGTGGTGCAGTTTCGCTCAGAGCTTG
TCTCCTTGGCTTCCAACCCCAGAAATGCCTGCTGGGCCTTAAGCTTTCCAGGGGCCGGGGCAGTGGGGAGCCCCCATCCCTTCACACCGC
CACCAACTAACCAAGCTTGGCCTCTGACTCCCGTCTCTGTGCTTGCCCCCATCTCAGGGACCATGATGTCTCAGTCACTCCACGCTCCCC
ACAGGCCAACCCTGGCACAGGTCATGTCTGCAGCCCCCAGAATGTTCTGGACATGCACCACCAGCCGGTGGTCCCAATGTCCACCCCTGC
CTCCCCTTCACTGGGGACTGGGGTTTTCGCCCCATGCTGCATCGTGTTGTATTGGGATGGGGCTGAGGAACATGCTCCCTCCCTCCCTCC
CATAAAATGCCTGCTCTTCACCTCCCACCTTTGTGGGGGGCTTTTGAGGACCCAGCTGCGTCAGGAGTTTTGCTTCAAGATGTCAGAAAG
TCAAGTTCAGCTAAGAGACACCCAGGTCCCCAGCTTGCCCTGAGCAGCCCTTCAGGGCTTCTGGTTCCTTCTGCCGCCCTTCCTGAGACC
TTAGAAACCAGAAGAGCCATACAGTCAGTGGAAGGCGGGGGGGCCCTGGCCTCTGCACCGGGATCCCAGTGGGAACCTTCATGCCTTATT
TATTTCTAATGGGTAAAGGGGTTTTCTTACCAAGCATCCCTGACCTCCTGGAGACACCACCTGCTTTCCGGGCGGCACTGTGATGGGAGC
TGGTGGCGACTGAGTCCTTCTGTACGTGCAACTGGGAAACTTTTGTCCTTTGAGGCTAGGCAGCTCCCTGCCCTCCGTGTGTGTCTGTTA
TCTGGGGGAGAGGAGTGTGGAAGGGTTGGGGGAAGAGCTCCAGCCTGTCTGCTCCCCAGCTCTGTAGTGGCAGACCAGCGTCACCTTTGA

>6665_6665_2_ARMC7-CDR2L_ARMC7_chr17_73106701_ENST00000582136_CDR2L_chr17_72995599_ENST00000337231_length(amino acids)=535AA_BP=96
MHLSHPPARPWGSSVTAAMAQKPKVDPHVGRLGYLQALVTEFQETQSQDAKEQVLANLANFAYDPSNYEYLRQLQVLDLFLDSLSEENET
LVEFAIDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQEIEYLTKQLDTLRHVNEQHAKVYEQLDLTARDLELTNHRLVLESKAAQQ
KIHGLTETIERLQAQVEELQAQVEQLRGLEQLRVLREKRERRRTIHTFPCLKELCTSPRCKDAFRLHSSSLELGPRPLEQENERLQTLVG
ALRSQVSQERQRKERAEREYTAVLQEYSELERQLCEMEACRLRVQELEAELLELQQMKQAKTYLLGPDDHLAEALLAPLTQAPEADDPQP
GRGDDLGAQDGVSSPAASPGHVVRKSCSDTALNAIVAKDPASRHAGNLTLHANSVRKRGMSILREVDEQYHALLEKYEELLSKCRQHGAG

--------------------------------------------------------------
>6665_6665_3_ARMC7-CDR2L_ARMC7_chr17_73106701_ENST00000584947_CDR2L_chr17_72995599_ENST00000337231_length(transcript)=3388nt_BP=343nt
TCTTCCCTCTCCAGACAGGTGGAGAGCGGGTGAGGGTCTCGCTCGGCTTTCCCCCTGCACCTTTCCCACCCTCCCGCCCGTCCCTGGGGG
TCCTCCGTCACCGCGGCCATGGCCCAGAAGCCGAAGGTGGACCCCCACGTCGGGCGGCTGGGATACCTGCAGGCGCTGGTCACGGAATTC
CAGGAGACCCAAAGCCAAGACGCCAAGGAGCAAGTCCTCGCCAACCTCGCCAACTTCGCTTATGACCCCAGCAACTACGAGTATCTGCGG
CAGCTGCAGGTCCTGGATTTATTTCTCGATTCGCTGTCGGAGGAGAATGAGACCCTGGTGGAGTTTGCTATTGACTTGCACCTAGCTGCG
GAGCTGGGGAAGACTCTGCTGGAGAGGAACAAGGAGCTGGAGGGGTCCCTGCAGCAGATGTACTCCACCAATGAGGAACAGGTGCAGGAG
ATCGAGTACCTAACCAAGCAGCTGGACACGCTGCGGCACGTGAACGAGCAGCACGCCAAAGTCTATGAGCAGCTGGACCTGACAGCCCGG
GACCTGGAGCTGACCAACCACAGGCTGGTGCTGGAGAGTAAGGCTGCCCAGCAGAAGATCCATGGGCTGACGGAGACCATTGAGCGCCTC
CAGGCTCAGGTGGAGGAGCTGCAGGCCCAGGTGGAGCAACTGAGAGGCCTGGAACAGCTGCGAGTGCTCCGGGAGAAGCGGGAACGCAGG
CGTACCATCCACACCTTCCCCTGCCTCAAGGAGCTGTGCACCAGCCCCCGGTGCAAGGATGCTTTCCGCCTACACAGTTCCTCCCTGGAG
CTGGGCCCGCGGCCCCTGGAGCAGGAGAACGAGCGGCTGCAGACCCTGGTGGGGGCGCTGCGCTCCCAGGTGAGCCAGGAGCGGCAGCGC
AAGGAGCGGGCGGAGCGCGAGTACACCGCGGTGCTGCAGGAGTACTCGGAGCTGGAGCGCCAGCTGTGCGAGATGGAGGCCTGTCGCCTG
CGTGTGCAGGAGCTGGAGGCCGAGCTGCTGGAGCTGCAGCAGATGAAGCAGGCCAAGACCTACCTACTGGGTCCGGACGACCACCTGGCC
GAGGCCCTGCTCGCACCCCTCACGCAGGCCCCTGAGGCCGACGATCCCCAGCCCGGCCGCGGGGACGACTTGGGCGCCCAGGACGGGGTC
TCCTCACCGGCAGCCTCTCCAGGCCACGTGGTGCGCAAGAGCTGCAGCGACACTGCGCTCAACGCCATCGTGGCCAAAGACCCAGCCAGC
CGGCACGCGGGCAACCTCACACTGCACGCCAACAGCGTGCGCAAGCGGGGCATGTCCATCCTGCGGGAGGTGGACGAGCAGTACCACGCG
CTGCTGGAGAAGTACGAGGAGCTGCTGAGCAAGTGCCGGCAGCACGGGGCCGGAGTGCGGCACGCCGGCGTGCAGACCTCGCGCCCCATC
TCCCGGGACAGCTCGTGGAGGGACCTGCGCGGGGGTGAGGAGGGCCAGGGTGAGGTCAAGGCAGGAGAGAAGAGCCTGAGCCAGCACGTG
GAGGCCGTGGACAAGCGGCTGGAACAGAGCCAGCCCGAGTACAAGGCGCTCTTCAAAGAGATCTTCTCCAGGATCCAGAAGACCAAGGCT
GACATCAACGCCACCAAAGTCAAGACGCACAGCAGCAAGTGACCCTTCTCCGGCCTGCAGCCTCCCCCAGGGTGGAAGCCGTGGGGTCCC
TCAGGCCTGGGCGGTGCAGCTTCCAGAGAGCGAGCGCCCTTTAGCGGCCTGCCACCACAGCACGCGGCCTCCTGATCCGGAAGCACGCAG
CATGTTCCCTGCTGAGCGGAGGCAGCCCACCTGTCCTGCCTCCCAGGAGCCCTTGGCCACCTCGCGCCAGCCCAAAGGCGCAGCTCTGAG
TTCAAAGCCAAATGTCCCCACTACCCCAGGGATCCCCCAGCTCCCCCAGCCCCTGGCTTCCTGACCCTGCGCCTCACCCTCAGACTGGTG
ACCAGGCTTCTGAAAGCCATTCTGGATCAGTTGGCTTTTTTTTTTTTTTTGGTTAAGTTTGTTTTTTCTAAGAGATTTGCAATGCAAGGT
CTCCTTGACCCCTTGCCACAACTGGAAACACTTGAAAGGGGACCCCAGGGCCAGCTGTTTCAGGGGTTTCCTGGACCACCCACTGCTTCT
CCCCAACCCTGATGCGCTGACATTCCCTTAGCACCAGCTGTCCCACCTCCAGGGTCCTGACCAGGTCAGAGATGTCCCCTGCCATGCAGA
GCAGGAAGCCTCAGCTGGGCCTGGAGTGTCCCTGCTCCAGCCCTGCCAGGGACAGGTTTCTCCCTGGATACTCTTGGCCCACCGCAGATC
TGTAGCCAGTCAGAGGAGGAGGAGAAGGAGCCCCTCAGCAGAGTGGTGCAGTTTCGCTCAGAGCTTGTCTCCTTGGCTTCCAACCCCAGA
AATGCCTGCTGGGCCTTAAGCTTTCCAGGGGCCGGGGCAGTGGGGAGCCCCCATCCCTTCACACCGCCACCAACTAACCAAGCTTGGCCT
CTGACTCCCGTCTCTGTGCTTGCCCCCATCTCAGGGACCATGATGTCTCAGTCACTCCACGCTCCCCACAGGCCAACCCTGGCACAGGTC
ATGTCTGCAGCCCCCAGAATGTTCTGGACATGCACCACCAGCCGGTGGTCCCAATGTCCACCCCTGCCTCCCCTTCACTGGGGACTGGGG
TTTTCGCCCCATGCTGCATCGTGTTGTATTGGGATGGGGCTGAGGAACATGCTCCCTCCCTCCCTCCCATAAAATGCCTGCTCTTCACCT
CCCACCTTTGTGGGGGGCTTTTGAGGACCCAGCTGCGTCAGGAGTTTTGCTTCAAGATGTCAGAAAGTCAAGTTCAGCTAAGAGACACCC
AGGTCCCCAGCTTGCCCTGAGCAGCCCTTCAGGGCTTCTGGTTCCTTCTGCCGCCCTTCCTGAGACCTTAGAAACCAGAAGAGCCATACA
GTCAGTGGAAGGCGGGGGGGCCCTGGCCTCTGCACCGGGATCCCAGTGGGAACCTTCATGCCTTATTTATTTCTAATGGGTAAAGGGGTT
TTCTTACCAAGCATCCCTGACCTCCTGGAGACACCACCTGCTTTCCGGGCGGCACTGTGATGGGAGCTGGTGGCGACTGAGTCCTTCTGT
ACGTGCAACTGGGAAACTTTTGTCCTTTGAGGCTAGGCAGCTCCCTGCCCTCCGTGTGTGTCTGTTATCTGGGGGAGAGGAGTGTGGAAG
GGTTGGGGGAAGAGCTCCAGCCTGTCTGCTCCCCAGCTCTGTAGTGGCAGACCAGCGTCACCTTTGAAGTATACGTGAGAGAAATATATT

>6665_6665_3_ARMC7-CDR2L_ARMC7_chr17_73106701_ENST00000584947_CDR2L_chr17_72995599_ENST00000337231_length(amino acids)=535AA_BP=96
MHLSHPPARPWGSSVTAAMAQKPKVDPHVGRLGYLQALVTEFQETQSQDAKEQVLANLANFAYDPSNYEYLRQLQVLDLFLDSLSEENET
LVEFAIDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQEIEYLTKQLDTLRHVNEQHAKVYEQLDLTARDLELTNHRLVLESKAAQQ
KIHGLTETIERLQAQVEELQAQVEQLRGLEQLRVLREKRERRRTIHTFPCLKELCTSPRCKDAFRLHSSSLELGPRPLEQENERLQTLVG
ALRSQVSQERQRKERAEREYTAVLQEYSELERQLCEMEACRLRVQELEAELLELQQMKQAKTYLLGPDDHLAEALLAPLTQAPEADDPQP
GRGDDLGAQDGVSSPAASPGHVVRKSCSDTALNAIVAKDPASRHAGNLTLHANSVRKRGMSILREVDEQYHALLEKYEELLSKCRQHGAG

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ARMC7-CDR2L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for ARMC7-CDR2L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for ARMC7-CDR2L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource