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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
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Fusion gene:PMPCB-WWOX (FusionGDB2 ID:66669)

Fusion Gene Summary for PMPCB-WWOX

Fusion gene summary

Fusion gene information	Fusion gene name: PMPCB-WWOX
	Fusion gene ID: 66669
		Hgene	Tgene
	Gene symbol	PMPCB	WWOX
	Gene ID	9512	51741
	Gene name	peptidase, mitochondrial processing subunit beta	WW domain containing oxidoreductase
	Synonyms	Beta-MPP\|MPP11\|MPPB\|MPPP52\|P-52	D16S432E\|EIEE28\|FOR\|FRA16D\|HHCMA56\|PRO0128\|SCAR12\|SDR41C1\|WOX1
	Cytomap	7q22.1	16q23.1-q23.2
	Type of gene	protein-coding	protein-coding
	Description	mitochondrial-processing peptidase subunit betamitochondrial processing peptidase beta subunitpeptidase (mitochondrial processing) betapeptidase, mitochondrial processing beta subunit	WW domain-containing oxidoreductaseWW domain-containing protein WWOXfragile site FRA16D oxidoreductaseshort chain dehydrogenase/reductase family 41C member 1
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000249269, ENST00000428154, ENST00000420236,	ENST00000355860, ENST00000408984, ENST00000565791, ENST00000569818, ENST00000402655, ENST00000406884, ENST00000539474, ENST00000566780,
Fusion gene scores	* DoF score	5 X 5 X 4=100	30 X 23 X 10=6900
	# samples	6	36
	** MAII score	log2(6/100*10)=-0.736965594166206 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(36/6900*10)=-4.26052755022322 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: PMPCB [Title/Abstract] AND WWOX [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	PMPCB(102939155)-WWOX(79245505), # samples:3
Anticipated loss of major functional domain due to fusion event.	PMPCB-WWOX seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. PMPCB-WWOX seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. PMPCB-WWOX seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. PMPCB-WWOX seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PMPCB	GO:0006627	protein processing involved in protein targeting to mitochondrion	22354088
Tgene	WWOX	GO:0030178	negative regulation of Wnt signaling pathway	19465938
Tgene	WWOX	GO:0071560	cellular response to transforming growth factor beta stimulus	19366691

Fusion gene breakpoints across PMPCB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across WWOX (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-VQ-A928-01A	PMPCB	chr7	102939155	-	WWOX	chr16	79245505	+
ChimerDB4	STAD	TCGA-VQ-A928-01A	PMPCB	chr7	102939155	+	WWOX	chr16	79245505	+
ChimerDB4	STAD	TCGA-VQ-A928	PMPCB	chr7	102939155	+	WWOX	chr16	79245504	+

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Fusion Gene ORF analysis for PMPCB-WWOX

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000249269	ENST00000355860	PMPCB	chr7	102939155	+	WWOX	chr16	79245505	+
5CDS-intron	ENST00000249269	ENST00000355860	PMPCB	chr7	102939155	+	WWOX	chr16	79245504	+
5CDS-intron	ENST00000249269	ENST00000408984	PMPCB	chr7	102939155	+	WWOX	chr16	79245505	+
5CDS-intron	ENST00000249269	ENST00000408984	PMPCB	chr7	102939155	+	WWOX	chr16	79245504	+
5CDS-intron	ENST00000249269	ENST00000565791	PMPCB	chr7	102939155	+	WWOX	chr16	79245505	+
5CDS-intron	ENST00000249269	ENST00000565791	PMPCB	chr7	102939155	+	WWOX	chr16	79245504	+
5CDS-intron	ENST00000249269	ENST00000569818	PMPCB	chr7	102939155	+	WWOX	chr16	79245505	+
5CDS-intron	ENST00000249269	ENST00000569818	PMPCB	chr7	102939155	+	WWOX	chr16	79245504	+
5CDS-intron	ENST00000428154	ENST00000355860	PMPCB	chr7	102939155	+	WWOX	chr16	79245505	+
5CDS-intron	ENST00000428154	ENST00000355860	PMPCB	chr7	102939155	+	WWOX	chr16	79245504	+
5CDS-intron	ENST00000428154	ENST00000408984	PMPCB	chr7	102939155	+	WWOX	chr16	79245505	+
5CDS-intron	ENST00000428154	ENST00000408984	PMPCB	chr7	102939155	+	WWOX	chr16	79245504	+
5CDS-intron	ENST00000428154	ENST00000565791	PMPCB	chr7	102939155	+	WWOX	chr16	79245505	+
5CDS-intron	ENST00000428154	ENST00000565791	PMPCB	chr7	102939155	+	WWOX	chr16	79245504	+
5CDS-intron	ENST00000428154	ENST00000569818	PMPCB	chr7	102939155	+	WWOX	chr16	79245505	+
5CDS-intron	ENST00000428154	ENST00000569818	PMPCB	chr7	102939155	+	WWOX	chr16	79245504	+
5UTR-3CDS	ENST00000420236	ENST00000402655	PMPCB	chr7	102939155	+	WWOX	chr16	79245505	+
5UTR-3CDS	ENST00000420236	ENST00000402655	PMPCB	chr7	102939155	+	WWOX	chr16	79245504	+
5UTR-3CDS	ENST00000420236	ENST00000406884	PMPCB	chr7	102939155	+	WWOX	chr16	79245505	+
5UTR-3CDS	ENST00000420236	ENST00000406884	PMPCB	chr7	102939155	+	WWOX	chr16	79245504	+
5UTR-3CDS	ENST00000420236	ENST00000539474	PMPCB	chr7	102939155	+	WWOX	chr16	79245505	+
5UTR-3CDS	ENST00000420236	ENST00000539474	PMPCB	chr7	102939155	+	WWOX	chr16	79245504	+
5UTR-3CDS	ENST00000420236	ENST00000566780	PMPCB	chr7	102939155	+	WWOX	chr16	79245505	+
5UTR-3CDS	ENST00000420236	ENST00000566780	PMPCB	chr7	102939155	+	WWOX	chr16	79245504	+
5UTR-intron	ENST00000420236	ENST00000355860	PMPCB	chr7	102939155	+	WWOX	chr16	79245505	+
5UTR-intron	ENST00000420236	ENST00000355860	PMPCB	chr7	102939155	+	WWOX	chr16	79245504	+
5UTR-intron	ENST00000420236	ENST00000408984	PMPCB	chr7	102939155	+	WWOX	chr16	79245505	+
5UTR-intron	ENST00000420236	ENST00000408984	PMPCB	chr7	102939155	+	WWOX	chr16	79245504	+
5UTR-intron	ENST00000420236	ENST00000565791	PMPCB	chr7	102939155	+	WWOX	chr16	79245505	+
5UTR-intron	ENST00000420236	ENST00000565791	PMPCB	chr7	102939155	+	WWOX	chr16	79245504	+
5UTR-intron	ENST00000420236	ENST00000569818	PMPCB	chr7	102939155	+	WWOX	chr16	79245505	+
5UTR-intron	ENST00000420236	ENST00000569818	PMPCB	chr7	102939155	+	WWOX	chr16	79245504	+
Frame-shift	ENST00000249269	ENST00000402655	PMPCB	chr7	102939155	+	WWOX	chr16	79245505	+
Frame-shift	ENST00000249269	ENST00000402655	PMPCB	chr7	102939155	+	WWOX	chr16	79245504	+
Frame-shift	ENST00000249269	ENST00000406884	PMPCB	chr7	102939155	+	WWOX	chr16	79245505	+
Frame-shift	ENST00000249269	ENST00000406884	PMPCB	chr7	102939155	+	WWOX	chr16	79245504	+
Frame-shift	ENST00000249269	ENST00000566780	PMPCB	chr7	102939155	+	WWOX	chr16	79245505	+
Frame-shift	ENST00000249269	ENST00000566780	PMPCB	chr7	102939155	+	WWOX	chr16	79245504	+
Frame-shift	ENST00000428154	ENST00000402655	PMPCB	chr7	102939155	+	WWOX	chr16	79245505	+
Frame-shift	ENST00000428154	ENST00000402655	PMPCB	chr7	102939155	+	WWOX	chr16	79245504	+
Frame-shift	ENST00000428154	ENST00000406884	PMPCB	chr7	102939155	+	WWOX	chr16	79245505	+
Frame-shift	ENST00000428154	ENST00000406884	PMPCB	chr7	102939155	+	WWOX	chr16	79245504	+
Frame-shift	ENST00000428154	ENST00000566780	PMPCB	chr7	102939155	+	WWOX	chr16	79245505	+
Frame-shift	ENST00000428154	ENST00000566780	PMPCB	chr7	102939155	+	WWOX	chr16	79245504	+
In-frame	ENST00000249269	ENST00000539474	PMPCB	chr7	102939155	+	WWOX	chr16	79245505	+
In-frame	ENST00000249269	ENST00000539474	PMPCB	chr7	102939155	+	WWOX	chr16	79245504	+
In-frame	ENST00000428154	ENST00000539474	PMPCB	chr7	102939155	+	WWOX	chr16	79245505	+
In-frame	ENST00000428154	ENST00000539474	PMPCB	chr7	102939155	+	WWOX	chr16	79245504	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000249269

PMPCB

chr7

102939155

ENST00000539474

WWOX

chr16

79245505

1338

278

220

804

194

ENST00000428154

PMPCB

chr7

102939155

ENST00000539474

WWOX

chr16

79245505

1325

265

207

791

194

ENST00000249269

PMPCB

chr7

102939155

ENST00000539474

WWOX

chr16

79245504

1338

278

220

804

194

ENST00000428154

PMPCB

chr7

102939155

ENST00000539474

WWOX

chr16

79245504

1325

265

207

791

194

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000249269	ENST00000539474	PMPCB	chr7	102939155	+	WWOX	chr16	79245505	+	0.7298324	0.27016762
ENST00000428154	ENST00000539474	PMPCB	chr7	102939155	+	WWOX	chr16	79245505	+	0.7697847	0.23021531
ENST00000249269	ENST00000539474	PMPCB	chr7	102939155	+	WWOX	chr16	79245504	+	0.7298324	0.27016762
ENST00000428154	ENST00000539474	PMPCB	chr7	102939155	+	WWOX	chr16	79245504	+	0.7697847	0.23021531

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Fusion Genomic Features for PMPCB-WWOX

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
PMPCB	chr7	102939155	+	WWOX	chr16	79245504	+	0.000104776	0.9998952
PMPCB	chr7	102939155	+	WWOX	chr16	79245504	+	0.000104776	0.9998952
PMPCB	chr7	102939155	+	WWOX	chr16	79245504	+	0.000104776	0.9998952
PMPCB	chr7	102939155	+	WWOX	chr16	79245504	+	0.000104776	0.9998952

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PMPCB-WWOX

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:102939155/chr16:79245505)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

WWOX

chr7:102939155

chr16:79245504

ENST00000355860

16_49

190.0

Domain

WW 1

Tgene

WWOX

chr7:102939155

chr16:79245504

ENST00000355860

57_90

190.0

Domain

WW 2

Tgene

WWOX

chr7:102939155

chr16:79245504

ENST00000408984

16_49

311.6666666666667

Domain

WW 1

Tgene

WWOX

chr7:102939155

chr16:79245504

ENST00000408984

57_90

311.6666666666667

Domain

WW 2

Tgene

WWOX

chr7:102939155

chr16:79245504

ENST00000569818

16_49

37.0

Domain

WW 1

Tgene

WWOX

chr7:102939155

chr16:79245504

ENST00000569818

57_90

37.0

Domain

WW 2

Tgene

WWOX

chr7:102939155

chr16:79245505

ENST00000355860

16_49

190.0

Domain

WW 1

Tgene

WWOX

chr7:102939155

chr16:79245505

ENST00000355860

57_90

190.0

Domain

WW 2

Tgene

WWOX

chr7:102939155

chr16:79245505

ENST00000408984

16_49

311.6666666666667

Domain

WW 1

Tgene

WWOX

chr7:102939155

chr16:79245505

ENST00000408984

57_90

311.6666666666667

Domain

WW 2

Tgene

WWOX

chr7:102939155

chr16:79245505

ENST00000569818

16_49

37.0

Domain

WW 1

Tgene

WWOX

chr7:102939155

chr16:79245505

ENST00000569818

57_90

37.0

Domain

WW 2

Tgene

WWOX

chr7:102939155

chr16:79245504

ENST00000355860

50_55

190.0

Motif

Nuclear localization signal

Tgene

WWOX

chr7:102939155

chr16:79245504

ENST00000408984

50_55

311.6666666666667

Motif

Nuclear localization signal

Tgene

WWOX

chr7:102939155

chr16:79245504

ENST00000569818

50_55

37.0

Motif

Nuclear localization signal

Tgene

WWOX

chr7:102939155

chr16:79245505

ENST00000355860

50_55

190.0

Motif

Nuclear localization signal

Tgene

WWOX

chr7:102939155

chr16:79245505

ENST00000408984

50_55

311.6666666666667

Motif

Nuclear localization signal

Tgene

WWOX

chr7:102939155

chr16:79245505

ENST00000569818

50_55

37.0

Motif

Nuclear localization signal

Tgene

WWOX

chr7:102939155

chr16:79245504

ENST00000355860

131_137

190.0

Nucleotide binding

NADP

Tgene

WWOX

chr7:102939155

chr16:79245504

ENST00000408984

131_137

311.6666666666667

Nucleotide binding

NADP

Tgene

WWOX

chr7:102939155

chr16:79245504

ENST00000569818

131_137

37.0

Nucleotide binding

NADP

Tgene

WWOX

chr7:102939155

chr16:79245505

ENST00000355860

131_137

190.0

Nucleotide binding

NADP

Tgene

WWOX

chr7:102939155

chr16:79245505

ENST00000408984

131_137

311.6666666666667

Nucleotide binding

NADP

Tgene

WWOX

chr7:102939155

chr16:79245505

ENST00000569818

131_137

37.0

Nucleotide binding

NADP

Tgene

WWOX

chr7:102939155

chr16:79245504

ENST00000355860

209_273

190.0

Region

Mediates targeting to the mitochondria

Tgene

WWOX

chr7:102939155

chr16:79245504

ENST00000402655

209_273

136

312.0

Region

Mediates targeting to the mitochondria

Tgene

WWOX

chr7:102939155

chr16:79245504

ENST00000406884

209_273

172

235.0

Region

Mediates targeting to the mitochondria

Tgene

WWOX

chr7:102939155

chr16:79245504

ENST00000408984

209_273

311.6666666666667

Region

Mediates targeting to the mitochondria

Tgene

WWOX

chr7:102939155

chr16:79245504

ENST00000569818

209_273

37.0

Region

Mediates targeting to the mitochondria

Tgene

WWOX

chr7:102939155

chr16:79245505

ENST00000355860

209_273

190.0

Region

Mediates targeting to the mitochondria

Tgene

WWOX

chr7:102939155

chr16:79245505

ENST00000402655

209_273

136

312.0

Region

Mediates targeting to the mitochondria

Tgene

WWOX

chr7:102939155

chr16:79245505

ENST00000406884

209_273

172

235.0

Region

Mediates targeting to the mitochondria

Tgene

WWOX

chr7:102939155

chr16:79245505

ENST00000408984

209_273

311.6666666666667

Region

Mediates targeting to the mitochondria

Tgene

WWOX

chr7:102939155

chr16:79245505

ENST00000569818

209_273

37.0

Region

Mediates targeting to the mitochondria

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

WWOX

chr7:102939155

chr16:79245504

ENST00000402655

16_49

136

312.0

Domain

WW 1

Tgene

WWOX

chr7:102939155

chr16:79245504

ENST00000402655

57_90

136

312.0

Domain

WW 2

Tgene

WWOX

chr7:102939155

chr16:79245504

ENST00000406884

16_49

172

235.0

Domain

WW 1

Tgene

WWOX

chr7:102939155

chr16:79245504

ENST00000406884

57_90

172

235.0

Domain

WW 2

Tgene

WWOX

chr7:102939155

chr16:79245504

ENST00000566780

16_49

352

415.0

Domain

WW 1

Tgene

WWOX

chr7:102939155

chr16:79245504

ENST00000566780

57_90

352

415.0

Domain

WW 2

Tgene

WWOX

chr7:102939155

chr16:79245505

ENST00000402655

16_49

136

312.0

Domain

WW 1

Tgene

WWOX

chr7:102939155

chr16:79245505

ENST00000402655

57_90

136

312.0

Domain

WW 2

Tgene

WWOX

chr7:102939155

chr16:79245505

ENST00000406884

16_49

172

235.0

Domain

WW 1

Tgene

WWOX

chr7:102939155

chr16:79245505

ENST00000406884

57_90

172

235.0

Domain

WW 2

Tgene

WWOX

chr7:102939155

chr16:79245505

ENST00000566780

16_49

352

415.0

Domain

WW 1

Tgene

WWOX

chr7:102939155

chr16:79245505

ENST00000566780

57_90

352

415.0

Domain

WW 2

Tgene

WWOX

chr7:102939155

chr16:79245504

ENST00000402655

50_55

136

312.0

Motif

Nuclear localization signal

Tgene

WWOX

chr7:102939155

chr16:79245504

ENST00000406884

50_55

172

235.0

Motif

Nuclear localization signal

Tgene

WWOX

chr7:102939155

chr16:79245504

ENST00000566780

50_55

352

415.0

Motif

Nuclear localization signal

Tgene

WWOX

chr7:102939155

chr16:79245505

ENST00000402655

50_55

136

312.0

Motif

Nuclear localization signal

Tgene

WWOX

chr7:102939155

chr16:79245505

ENST00000406884

50_55

172

235.0

Motif

Nuclear localization signal

Tgene

WWOX

chr7:102939155

chr16:79245505

ENST00000566780

50_55

352

415.0

Motif

Nuclear localization signal

Tgene

WWOX

chr7:102939155

chr16:79245504

ENST00000402655

131_137

136

312.0

Nucleotide binding

NADP

Tgene

WWOX

chr7:102939155

chr16:79245504

ENST00000406884

131_137

172

235.0

Nucleotide binding

NADP

Tgene

WWOX

chr7:102939155

chr16:79245504

ENST00000566780

131_137

352

415.0

Nucleotide binding

NADP

Tgene

WWOX

chr7:102939155

chr16:79245505

ENST00000402655

131_137

136

312.0

Nucleotide binding

NADP

Tgene

WWOX

chr7:102939155

chr16:79245505

ENST00000406884

131_137

172

235.0

Nucleotide binding

NADP

Tgene

WWOX

chr7:102939155

chr16:79245505

ENST00000566780

131_137

352

415.0

Nucleotide binding

NADP

Tgene

WWOX

chr7:102939155

chr16:79245504

ENST00000566780

209_273

352

415.0

Region

Mediates targeting to the mitochondria

Tgene

WWOX

chr7:102939155

chr16:79245505

ENST00000566780

209_273

352

415.0

Region

Mediates targeting to the mitochondria

Top

Fusion Gene Sequence for PMPCB-WWOX

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>66669_66669_1_PMPCB-WWOX_PMPCB_chr7_102939155_ENST00000249269_WWOX_chr16_79245504_ENST00000539474_length(transcript)=1338nt_BP=278nt
AAGCACATCCTTCATCCTCTACCTTCCTTCTAGCAGAAATGGCGGCTGCGGCGGCTCGAGTGGTGTTGTCATCCGCGGCGCGGCGGCGGC
TCTGGGGTTTCAGCGAGAGTCTTCTAATCCGAGGCGCTGCGGGACGGTCATTATATTTTGGAGAGAACAGATTAAGAAGTACACAGGCTG
CTACCCAAGTTGTTCTGAATGTTCCTGAAACAAGAGTAACATGTTTAGAAAGTGGACTCAGAGTAGCTTCGGAAGACTCTGGGCTCTCAA
CATGCACACAACAGGGAGCTGCCACCACCGTGTACTGTGCTGCTGTCCCAGAACTGGAGGGTCTGGGAGGGATGTACTTCAACAACTGCT
GCCGCTGCATGCCCTCACCAGAAGCTCAGAGCGAAGAGACGGCCCGGACCCTGTGGGCGCTCAGCGAGAGGCTGATCCAAGAACGGCTTG
GCAGCCAGTCCGGCTAAGTGGAGCTCAGAGCGGATGGGCACACACACCCGCCCTGTGTGTGTCCCCTCACGCAAGTGCCAGGGCTGGGCC
CCTTCCAAATGTCCCTCCAACACAGATCCGCAAGAGTAAAGGAAATAAGAGCAGTCACAACAGAGTGAAAAATCTTAAGTACCAATGGGA
AGCAGGGAATTCCTGGGGTAAAGTATCACTTTTCTGGGGCTGGGCTAGGCATAGGTCTCTTTGCTTTCTGGTGGTGGCCTGTTTGAAAGT
AAAAACCTGCTTGGTGTGTAGGTTCCGTATCTCCCTGGAGAAGCACCAGCAATTCTCTTTCTTTTACTGTTATAGAATAGCCTGAGGTCC
CCTCGTCCCATCCAGCTACCACCACGGCCACCACTGCAGCCGGGGGCTGGCCTTCTCCTACTTAGGGAAGAAAAAGCAAGTGTTCACTGC
TCCTTGCTGCATTGATCCAGGAGATAATTGTTTCATTCATCCTGACCAAGACTGAGCCAGCTTAGCAACTGCTGGGGAGACAAATCTCAG
AACCTTGTCCCAGCCAGTGAGGATGACAGTGACACCCAGAGGGAGTAGAATACGCAGAACTACCAGGTGGCAAAGTACTTGTCATAGACT
CCTTTGCTAATGCTATGCAAAAAATTCTTTAGAGATTATAACAAATTTTTCAAATCATTCCTTAGATACCTTGAAAGGCAGGAAGGGAAG
CGTATATACTTAAGAATACACAGGATATTTTGGGGGGCAGAGAATAAAACGTTAGTTAATCCCTTTGTCTGTCAATCACAGTCTCAGTTC

>66669_66669_1_PMPCB-WWOX_PMPCB_chr7_102939155_ENST00000249269_WWOX_chr16_79245504_ENST00000539474_length(amino acids)=194AA_BP=20
MFRKWTQSSFGRLWALNMHTTGSCHHRVLCCCPRTGGSGRDVLQQLLPLHALTRSSERRDGPDPVGAQREADPRTAWQPVRLSGAQSGWA
HTPALCVSPHASARAGPLPNVPPTQIRKSKGNKSSHNRVKNLKYQWEAGNSWGKVSLFWGWARHRSLCFLVVACLKVKTCLVCRFRISLE

--------------------------------------------------------------
>66669_66669_2_PMPCB-WWOX_PMPCB_chr7_102939155_ENST00000249269_WWOX_chr16_79245505_ENST00000539474_length(transcript)=1338nt_BP=278nt
AAGCACATCCTTCATCCTCTACCTTCCTTCTAGCAGAAATGGCGGCTGCGGCGGCTCGAGTGGTGTTGTCATCCGCGGCGCGGCGGCGGC
TCTGGGGTTTCAGCGAGAGTCTTCTAATCCGAGGCGCTGCGGGACGGTCATTATATTTTGGAGAGAACAGATTAAGAAGTACACAGGCTG
CTACCCAAGTTGTTCTGAATGTTCCTGAAACAAGAGTAACATGTTTAGAAAGTGGACTCAGAGTAGCTTCGGAAGACTCTGGGCTCTCAA
CATGCACACAACAGGGAGCTGCCACCACCGTGTACTGTGCTGCTGTCCCAGAACTGGAGGGTCTGGGAGGGATGTACTTCAACAACTGCT
GCCGCTGCATGCCCTCACCAGAAGCTCAGAGCGAAGAGACGGCCCGGACCCTGTGGGCGCTCAGCGAGAGGCTGATCCAAGAACGGCTTG
GCAGCCAGTCCGGCTAAGTGGAGCTCAGAGCGGATGGGCACACACACCCGCCCTGTGTGTGTCCCCTCACGCAAGTGCCAGGGCTGGGCC
CCTTCCAAATGTCCCTCCAACACAGATCCGCAAGAGTAAAGGAAATAAGAGCAGTCACAACAGAGTGAAAAATCTTAAGTACCAATGGGA
AGCAGGGAATTCCTGGGGTAAAGTATCACTTTTCTGGGGCTGGGCTAGGCATAGGTCTCTTTGCTTTCTGGTGGTGGCCTGTTTGAAAGT
AAAAACCTGCTTGGTGTGTAGGTTCCGTATCTCCCTGGAGAAGCACCAGCAATTCTCTTTCTTTTACTGTTATAGAATAGCCTGAGGTCC
CCTCGTCCCATCCAGCTACCACCACGGCCACCACTGCAGCCGGGGGCTGGCCTTCTCCTACTTAGGGAAGAAAAAGCAAGTGTTCACTGC
TCCTTGCTGCATTGATCCAGGAGATAATTGTTTCATTCATCCTGACCAAGACTGAGCCAGCTTAGCAACTGCTGGGGAGACAAATCTCAG
AACCTTGTCCCAGCCAGTGAGGATGACAGTGACACCCAGAGGGAGTAGAATACGCAGAACTACCAGGTGGCAAAGTACTTGTCATAGACT
CCTTTGCTAATGCTATGCAAAAAATTCTTTAGAGATTATAACAAATTTTTCAAATCATTCCTTAGATACCTTGAAAGGCAGGAAGGGAAG
CGTATATACTTAAGAATACACAGGATATTTTGGGGGGCAGAGAATAAAACGTTAGTTAATCCCTTTGTCTGTCAATCACAGTCTCAGTTC

>66669_66669_2_PMPCB-WWOX_PMPCB_chr7_102939155_ENST00000249269_WWOX_chr16_79245505_ENST00000539474_length(amino acids)=194AA_BP=20
MFRKWTQSSFGRLWALNMHTTGSCHHRVLCCCPRTGGSGRDVLQQLLPLHALTRSSERRDGPDPVGAQREADPRTAWQPVRLSGAQSGWA
HTPALCVSPHASARAGPLPNVPPTQIRKSKGNKSSHNRVKNLKYQWEAGNSWGKVSLFWGWARHRSLCFLVVACLKVKTCLVCRFRISLE

--------------------------------------------------------------
>66669_66669_3_PMPCB-WWOX_PMPCB_chr7_102939155_ENST00000428154_WWOX_chr16_79245504_ENST00000539474_length(transcript)=1325nt_BP=265nt
ATCCTCTACCTTCCTTCTAGCAGAAATGGCGGCTGCGGCGGCTCGAGTGGTGTTGTCATCCGCGGCGCGGCGGCGGCTCTGGGGTTTCAG
CGAGAGTCTTCTAATCCGAGGCGCTGCGGGACGGTCATTATATTTTGGAGAGAACAGATTAAGAAGTACACAGGCTGCTACCCAAGTTGT
TCTGAATGTTCCTGAAACAAGAGTAACATGTTTAGAAAGTGGACTCAGAGTAGCTTCGGAAGACTCTGGGCTCTCAACATGCACACAACA
GGGAGCTGCCACCACCGTGTACTGTGCTGCTGTCCCAGAACTGGAGGGTCTGGGAGGGATGTACTTCAACAACTGCTGCCGCTGCATGCC
CTCACCAGAAGCTCAGAGCGAAGAGACGGCCCGGACCCTGTGGGCGCTCAGCGAGAGGCTGATCCAAGAACGGCTTGGCAGCCAGTCCGG
CTAAGTGGAGCTCAGAGCGGATGGGCACACACACCCGCCCTGTGTGTGTCCCCTCACGCAAGTGCCAGGGCTGGGCCCCTTCCAAATGTC
CCTCCAACACAGATCCGCAAGAGTAAAGGAAATAAGAGCAGTCACAACAGAGTGAAAAATCTTAAGTACCAATGGGAAGCAGGGAATTCC
TGGGGTAAAGTATCACTTTTCTGGGGCTGGGCTAGGCATAGGTCTCTTTGCTTTCTGGTGGTGGCCTGTTTGAAAGTAAAAACCTGCTTG
GTGTGTAGGTTCCGTATCTCCCTGGAGAAGCACCAGCAATTCTCTTTCTTTTACTGTTATAGAATAGCCTGAGGTCCCCTCGTCCCATCC
AGCTACCACCACGGCCACCACTGCAGCCGGGGGCTGGCCTTCTCCTACTTAGGGAAGAAAAAGCAAGTGTTCACTGCTCCTTGCTGCATT
GATCCAGGAGATAATTGTTTCATTCATCCTGACCAAGACTGAGCCAGCTTAGCAACTGCTGGGGAGACAAATCTCAGAACCTTGTCCCAG
CCAGTGAGGATGACAGTGACACCCAGAGGGAGTAGAATACGCAGAACTACCAGGTGGCAAAGTACTTGTCATAGACTCCTTTGCTAATGC
TATGCAAAAAATTCTTTAGAGATTATAACAAATTTTTCAAATCATTCCTTAGATACCTTGAAAGGCAGGAAGGGAAGCGTATATACTTAA
GAATACACAGGATATTTTGGGGGGCAGAGAATAAAACGTTAGTTAATCCCTTTGTCTGTCAATCACAGTCTCAGTTCTCTTGCTTTCACA

>66669_66669_3_PMPCB-WWOX_PMPCB_chr7_102939155_ENST00000428154_WWOX_chr16_79245504_ENST00000539474_length(amino acids)=194AA_BP=20
MFRKWTQSSFGRLWALNMHTTGSCHHRVLCCCPRTGGSGRDVLQQLLPLHALTRSSERRDGPDPVGAQREADPRTAWQPVRLSGAQSGWA
HTPALCVSPHASARAGPLPNVPPTQIRKSKGNKSSHNRVKNLKYQWEAGNSWGKVSLFWGWARHRSLCFLVVACLKVKTCLVCRFRISLE

--------------------------------------------------------------
>66669_66669_4_PMPCB-WWOX_PMPCB_chr7_102939155_ENST00000428154_WWOX_chr16_79245505_ENST00000539474_length(transcript)=1325nt_BP=265nt
ATCCTCTACCTTCCTTCTAGCAGAAATGGCGGCTGCGGCGGCTCGAGTGGTGTTGTCATCCGCGGCGCGGCGGCGGCTCTGGGGTTTCAG
CGAGAGTCTTCTAATCCGAGGCGCTGCGGGACGGTCATTATATTTTGGAGAGAACAGATTAAGAAGTACACAGGCTGCTACCCAAGTTGT
TCTGAATGTTCCTGAAACAAGAGTAACATGTTTAGAAAGTGGACTCAGAGTAGCTTCGGAAGACTCTGGGCTCTCAACATGCACACAACA
GGGAGCTGCCACCACCGTGTACTGTGCTGCTGTCCCAGAACTGGAGGGTCTGGGAGGGATGTACTTCAACAACTGCTGCCGCTGCATGCC
CTCACCAGAAGCTCAGAGCGAAGAGACGGCCCGGACCCTGTGGGCGCTCAGCGAGAGGCTGATCCAAGAACGGCTTGGCAGCCAGTCCGG
CTAAGTGGAGCTCAGAGCGGATGGGCACACACACCCGCCCTGTGTGTGTCCCCTCACGCAAGTGCCAGGGCTGGGCCCCTTCCAAATGTC
CCTCCAACACAGATCCGCAAGAGTAAAGGAAATAAGAGCAGTCACAACAGAGTGAAAAATCTTAAGTACCAATGGGAAGCAGGGAATTCC
TGGGGTAAAGTATCACTTTTCTGGGGCTGGGCTAGGCATAGGTCTCTTTGCTTTCTGGTGGTGGCCTGTTTGAAAGTAAAAACCTGCTTG
GTGTGTAGGTTCCGTATCTCCCTGGAGAAGCACCAGCAATTCTCTTTCTTTTACTGTTATAGAATAGCCTGAGGTCCCCTCGTCCCATCC
AGCTACCACCACGGCCACCACTGCAGCCGGGGGCTGGCCTTCTCCTACTTAGGGAAGAAAAAGCAAGTGTTCACTGCTCCTTGCTGCATT
GATCCAGGAGATAATTGTTTCATTCATCCTGACCAAGACTGAGCCAGCTTAGCAACTGCTGGGGAGACAAATCTCAGAACCTTGTCCCAG
CCAGTGAGGATGACAGTGACACCCAGAGGGAGTAGAATACGCAGAACTACCAGGTGGCAAAGTACTTGTCATAGACTCCTTTGCTAATGC
TATGCAAAAAATTCTTTAGAGATTATAACAAATTTTTCAAATCATTCCTTAGATACCTTGAAAGGCAGGAAGGGAAGCGTATATACTTAA
GAATACACAGGATATTTTGGGGGGCAGAGAATAAAACGTTAGTTAATCCCTTTGTCTGTCAATCACAGTCTCAGTTCTCTTGCTTTCACA

>66669_66669_4_PMPCB-WWOX_PMPCB_chr7_102939155_ENST00000428154_WWOX_chr16_79245505_ENST00000539474_length(amino acids)=194AA_BP=20
MFRKWTQSSFGRLWALNMHTTGSCHHRVLCCCPRTGGSGRDVLQQLLPLHALTRSSERRDGPDPVGAQREADPRTAWQPVRLSGAQSGWA
HTPALCVSPHASARAGPLPNVPPTQIRKSKGNKSSHNRVKNLKYQWEAGNSWGKVSLFWGWARHRSLCFLVVACLKVKTCLVCRFRISLE

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for PMPCB-WWOX

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Tgene	WWOX	chr7:102939155	chr16:79245504	ENST00000355860		0	6	125_414	0	190.0	MAPT
Tgene	WWOX	chr7:102939155	chr16:79245504	ENST00000408984		0	10	125_414	0	311.6666666666667	MAPT
Tgene	WWOX	chr7:102939155	chr16:79245504	ENST00000569818		0	1	125_414	0	37.0	MAPT
Tgene	WWOX	chr7:102939155	chr16:79245505	ENST00000355860		0	6	125_414	0	190.0	MAPT
Tgene	WWOX	chr7:102939155	chr16:79245505	ENST00000408984		0	10	125_414	0	311.6666666666667	MAPT
Tgene	WWOX	chr7:102939155	chr16:79245505	ENST00000569818		0	1	125_414	0	37.0	MAPT

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	WWOX	chr7:102939155	chr16:79245504	ENST00000402655		3	5	125_414	136.33333333333334	312.0	MAPT
Tgene	WWOX	chr7:102939155	chr16:79245504	ENST00000406884		4	6	125_414	172.0	235.0	MAPT
Tgene	WWOX	chr7:102939155	chr16:79245504	ENST00000566780		7	9	125_414	352.0	415.0	MAPT
Tgene	WWOX	chr7:102939155	chr16:79245505	ENST00000402655		3	5	125_414	136.33333333333334	312.0	MAPT
Tgene	WWOX	chr7:102939155	chr16:79245505	ENST00000406884		4	6	125_414	172.0	235.0	MAPT
Tgene	WWOX	chr7:102939155	chr16:79245505	ENST00000566780		7	9	125_414	352.0	415.0	MAPT

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for PMPCB-WWOX

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for PMPCB-WWOX

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source