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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:PMS1-GCG (FusionGDB2 ID:66671) |
Fusion Gene Summary for PMS1-GCG |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PMS1-GCG | Fusion gene ID: 66671 | Hgene | Tgene | Gene symbol | PMS1 | GCG | Gene ID | 5378 | 2641 |
| Gene name | PMS1 homolog 1, mismatch repair system component | glucagon | |
| Synonyms | HNPCC3|MLH2|PMSL1|hPMS1 | GLP-1|GLP1|GLP2|GRPP | |
| Cytomap | 2q32.2 | 2q24.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | PMS1 protein homolog 1DNA mismatch repair protein PMS1PMS1 postmeiotic segregation increased 1human homolog of yeast mutLmismatch repair gene PMSL1rhabdomyosarcoma antigen MU-RMS-40.10Brhabdomyosarcoma antigen MU-RMS-40.10E | glucagonglicentin-related polypeptideglucagon-like peptide 1glucagon-like peptide 2preproglucagon | |
| Modification date | 20200327 | 20200313 | |
| UniProtAcc | PMS1 | P01275 | |
| Ensembl transtripts involved in fusion gene | ENST00000421722, ENST00000374826, ENST00000409823, ENST00000441310, ENST00000447232, ENST00000409985, ENST00000418224, ENST00000432292, | ENST00000375497, ENST00000418842, | |
| Fusion gene scores | * DoF score | 4 X 4 X 4=64 | 3 X 3 X 3=27 |
| # samples | 4 | 4 | |
| ** MAII score | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/27*10)=0.567040592723894 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: PMS1 [Title/Abstract] AND GCG [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | PMS1(190670480)-GCG(163004024), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | PMS1-GCG seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. PMS1-GCG seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across PMS1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across GCG (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | BRCA | TCGA-EW-A6S9-01A | PMS1 | chr2 | 190670480 | - | GCG | chr2 | 163004024 | - |
| ChimerDB4 | BRCA | TCGA-EW-A6S9-01A | PMS1 | chr2 | 190670480 | + | GCG | chr2 | 163004024 | - |
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Fusion Gene ORF analysis for PMS1-GCG |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3CDS | ENST00000421722 | ENST00000375497 | PMS1 | chr2 | 190670480 | + | GCG | chr2 | 163004024 | - |
| 3UTR-3CDS | ENST00000421722 | ENST00000418842 | PMS1 | chr2 | 190670480 | + | GCG | chr2 | 163004024 | - |
| Frame-shift | ENST00000374826 | ENST00000375497 | PMS1 | chr2 | 190670480 | + | GCG | chr2 | 163004024 | - |
| Frame-shift | ENST00000374826 | ENST00000418842 | PMS1 | chr2 | 190670480 | + | GCG | chr2 | 163004024 | - |
| Frame-shift | ENST00000409823 | ENST00000375497 | PMS1 | chr2 | 190670480 | + | GCG | chr2 | 163004024 | - |
| Frame-shift | ENST00000409823 | ENST00000418842 | PMS1 | chr2 | 190670480 | + | GCG | chr2 | 163004024 | - |
| Frame-shift | ENST00000441310 | ENST00000375497 | PMS1 | chr2 | 190670480 | + | GCG | chr2 | 163004024 | - |
| Frame-shift | ENST00000441310 | ENST00000418842 | PMS1 | chr2 | 190670480 | + | GCG | chr2 | 163004024 | - |
| Frame-shift | ENST00000447232 | ENST00000375497 | PMS1 | chr2 | 190670480 | + | GCG | chr2 | 163004024 | - |
| Frame-shift | ENST00000447232 | ENST00000418842 | PMS1 | chr2 | 190670480 | + | GCG | chr2 | 163004024 | - |
| In-frame | ENST00000409985 | ENST00000375497 | PMS1 | chr2 | 190670480 | + | GCG | chr2 | 163004024 | - |
| In-frame | ENST00000409985 | ENST00000418842 | PMS1 | chr2 | 190670480 | + | GCG | chr2 | 163004024 | - |
| intron-3CDS | ENST00000418224 | ENST00000375497 | PMS1 | chr2 | 190670480 | + | GCG | chr2 | 163004024 | - |
| intron-3CDS | ENST00000418224 | ENST00000418842 | PMS1 | chr2 | 190670480 | + | GCG | chr2 | 163004024 | - |
| intron-3CDS | ENST00000432292 | ENST00000375497 | PMS1 | chr2 | 190670480 | + | GCG | chr2 | 163004024 | - |
| intron-3CDS | ENST00000432292 | ENST00000418842 | PMS1 | chr2 | 190670480 | + | GCG | chr2 | 163004024 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000409985 | PMS1 | chr2 | 190670480 | + | ENST00000418842 | GCG | chr2 | 163004024 | - | 2712 | 1779 | 1825 | 2229 | 134 |
| ENST00000409985 | PMS1 | chr2 | 190670480 | + | ENST00000375497 | GCG | chr2 | 163004024 | - | 2230 | 1779 | 1825 | 2229 | 135 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000409985 | ENST00000418842 | PMS1 | chr2 | 190670480 | + | GCG | chr2 | 163004024 | - | 0.017313395 | 0.98268664 |
| ENST00000409985 | ENST00000375497 | PMS1 | chr2 | 190670480 | + | GCG | chr2 | 163004024 | - | 0.017716546 | 0.9822834 |
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Fusion Genomic Features for PMS1-GCG |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for PMS1-GCG |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:190670480/chr2:163004024) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PMS1 | GCG |
| 932 | FUNCTION: [Glucagon]: Plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes. {ECO:0000305|PubMed:10605628, ECO:0000305|PubMed:12626323}.; FUNCTION: [Glucagon-like peptide 1]: Potent stimulator of glucose-dependent insulin release. Also stimulates insulin release in response to IL6 (PubMed:22037645). Plays important roles on gastric motility and the suppression of plasma glucagon levels. May be involved in the suppression of satiety and stimulation of glucose disposal in peripheral tissues, independent of the actions of insulin. Has growth-promoting activities on intestinal epithelium. May also regulate the hypothalamic pituitary axis (HPA) via effects on LH, TSH, CRH, oxytocin, and vasopressin secretion. Increases islet mass through stimulation of islet neogenesis and pancreatic beta cell proliferation. Inhibits beta cell apoptosis (Probable). {ECO:0000269|PubMed:22037645, ECO:0000305|PubMed:10605628, ECO:0000305|PubMed:12554744, ECO:0000305|PubMed:14719035}.; FUNCTION: [Glucagon-like peptide 2]: Stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a key role in nutrient homeostasis, enhancing nutrient assimilation through enhanced gastrointestinal function, as well as increasing nutrient disposal. Stimulates intestinal glucose transport and decreases mucosal permeability. {ECO:0000305|PubMed:10322410, ECO:0000305|PubMed:10605628, ECO:0000305|PubMed:12554744, ECO:0000305|PubMed:14719035}.; FUNCTION: [Oxyntomodulin]: Significantly reduces food intake. Inhibits gastric emptying in humans. Suppression of gastric emptying may lead to increased gastric distension, which may contribute to satiety by causing a sensation of fullness. {ECO:0000305|PubMed:10605628, ECO:0000305|PubMed:12554744}.; FUNCTION: [Glicentin]: May modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life. {ECO:0000305|PubMed:10605628, ECO:0000305|PubMed:12554744}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PMS1 | chr2:190670480 | chr2:163004024 | ENST00000409823 | + | 4 | 12 | 571_639 | 139 | 894.0 | DNA binding | HMG box |
| Hgene | PMS1 | chr2:190670480 | chr2:163004024 | ENST00000441310 | + | 4 | 13 | 571_639 | 139 | 933.0 | DNA binding | HMG box |
| Hgene | PMS1 | chr2:190670480 | chr2:163004024 | ENST00000447232 | + | 4 | 12 | 571_639 | 139 | 771.0 | DNA binding | HMG box |
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Fusion Gene Sequence for PMS1-GCG |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >66671_66671_1_PMS1-GCG_PMS1_chr2_190670480_ENST00000409985_GCG_chr2_163004024_ENST00000375497_length(transcript)=2230nt_BP=1779nt AGTGCCGCGCTCTCTGCACCCGCTCTGCCGCGCGCGTGCGTGCTGGGTGCGGGTGCGGGTGCGGGGTTGGGCCTGCGCATCGGGTGAGAC GCTGGCTGCTTGCGGCTAGTGGATGGTAATTGCCTGCCTCGCGCTAGCAGGAAGCTGCTCTGTTAAAAGCGAAAATGAAACAATTGCCTG CGGCAACAGTTCGACTCCTTTCAAGTTCTCAGATCATCACTTCGGTGGTCAGTGTTGTAAAAGAGCTTATTGAAAACTCCTTGGATGCTG GTGCCACAAGCGTAGATGTTAAACTGGAGAACTATGGATTTGATAAAATTGAGGTGCGAGATAACGGGGAGGGTATCAAGGCTGTTGATG CACCTGTAATGGCAATGAAGTACTACACCTCAAAAATAAATAGTCATGAAGATCTTGAAAATTTGACAACTTACGGTTTTCGTGGAGAAG CCTTGGGGTCAATTTGTTGTATAGCTGAGGTAAGAAAGTAGCTTTGTATACAAACATTCTTTACCTTTTCTGTCTTAATTGTTGGTTTAA AAAAAAAAAGTTACTCGGTGAATACAAATATATTGCTTTGGGCTTGGTCCTGATAAAGGCTAGTTAACTTCCAAGTAAACATTCAGCCTT TATTCTAGCCACCAATTTCTTAAATATTTAGAATTGTTCTCAAAAGGAACTGTATGAGAGACTGGACACTTCCATGGACTAGTTACTCCT CTGTAAAAACTAAGAGTATTTATTTTACCAGTGCTGGATTACCAGTGTCATCTTCATATATGAAGAAGATTAAAATTTTATTGAAACATA TAAAACATAATTGATTTGGTAATAGTGGAAATAAACGATACCATCAAGATATGATTAAATAATTTAAAATCTATTTGTTAATTGATGGAA AACTTCAAACATGCATAAGAAGTTACTGTACTTATCACTCAGTTTCAATAATTTATCAATTCATTGCTAAAGTTCTTTCATGTAATACCC TCGCCCATTTCTTCCCTTTCTATATTACTTTGAAGCAAATACGTATTGTTTCTACTTGTAATGTAGTTAGTGTTTTATATACTTTTATGT AATATTATTACATTTTAATTGATATCTTATGTTTTTTATTTTATTTTATTTTATTTTCCTGAGACAGGGTCTCACTCTGTCACACAGGCT GGACTGCAGTGGCATCATCTTGGTTCACTGCAACCTCTGCCTCCCAGGCTCAAGTGATCCTCCCACCTCAGCCTCCTCAGTAGCTGGGAC TACAGGTGCATACCACCACACCCGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTTGCTGTGTTGCCCAGCTGGCCTCGAACTCCTG AGCCCAAGCGATACACCTGCCTTGGCCTCCCAGAGTGCTGAGATTACAGATGTGAGCCACTGTGTTCAGCTGATAAGTGTTTAAATTTCT CTAAAAACTATTTACTTATAAAGGTAAAAAAGATCTCTTTAGGCTTCAGTTTCACATATCTCCTTTAATCTTTTTTTAATAATTTCTAGT GATGGGATGATTAAGAGACTATTAAAGCTATTACCTCTTTAGAGTCATGTTCAAAATAATTATTAGATCTGAAAAGGGACTTGTGGGTTT TGTTGTTGTTGTTTATCCTTCTGCTTCTCCAATTTGTGTTGTAAATTCATGTTTAATTTTGTGTTCCCTCATTGCAGTTTATCAAAGTAC ATTCTGTATATTTTCTGTGGTTTTTTTCCTTCAGTTTTAATATTAAATTATTGGATTCTTTTTTTCAAAATCATTCTCAGCTTCCCAGGC AGACCCACTCAGTGATCCTGATCAGATGAACGAGGACAAGCGCCATTCACAGGGCACATTCACCAGTGACTACAGCAAGTATCTGGACTC CAGGCGTGCCCAAGATTTTGTGCAGTGGTTGATGAATACCAAGAGGAACAGGAATAACATTGCCAAACGTCACGATGAATTTGAGAGACA TGCTGAAGGGACCTTTACCAGTGATGTAAGTTCTTATTTGGAAGGCCAAGCTGCCAAGGAATTCATTGCTTGGCTGGTGAAAGGCCGAGG AAGGCGAGATTTCCCAGAAGAGGTCGCCATTGTTGAAGAACTTGGCCGCAGACATGCTGATGGTTCTTTCTCTGATGAGATGAACACCAT >66671_66671_1_PMS1-GCG_PMS1_chr2_190670480_ENST00000409985_GCG_chr2_163004024_ENST00000375497_length(amino acids)=135AA_BP= MNEDKRHSQGTFTSDYSKYLDSRRAQDFVQWLMNTKRNRNNIAKRHDEFERHAEGTFTSDVSSYLEGQAAKEFIAWLVKGRGRRDFPEEV -------------------------------------------------------------- >66671_66671_2_PMS1-GCG_PMS1_chr2_190670480_ENST00000409985_GCG_chr2_163004024_ENST00000418842_length(transcript)=2712nt_BP=1779nt AGTGCCGCGCTCTCTGCACCCGCTCTGCCGCGCGCGTGCGTGCTGGGTGCGGGTGCGGGTGCGGGGTTGGGCCTGCGCATCGGGTGAGAC GCTGGCTGCTTGCGGCTAGTGGATGGTAATTGCCTGCCTCGCGCTAGCAGGAAGCTGCTCTGTTAAAAGCGAAAATGAAACAATTGCCTG CGGCAACAGTTCGACTCCTTTCAAGTTCTCAGATCATCACTTCGGTGGTCAGTGTTGTAAAAGAGCTTATTGAAAACTCCTTGGATGCTG GTGCCACAAGCGTAGATGTTAAACTGGAGAACTATGGATTTGATAAAATTGAGGTGCGAGATAACGGGGAGGGTATCAAGGCTGTTGATG CACCTGTAATGGCAATGAAGTACTACACCTCAAAAATAAATAGTCATGAAGATCTTGAAAATTTGACAACTTACGGTTTTCGTGGAGAAG CCTTGGGGTCAATTTGTTGTATAGCTGAGGTAAGAAAGTAGCTTTGTATACAAACATTCTTTACCTTTTCTGTCTTAATTGTTGGTTTAA AAAAAAAAAGTTACTCGGTGAATACAAATATATTGCTTTGGGCTTGGTCCTGATAAAGGCTAGTTAACTTCCAAGTAAACATTCAGCCTT TATTCTAGCCACCAATTTCTTAAATATTTAGAATTGTTCTCAAAAGGAACTGTATGAGAGACTGGACACTTCCATGGACTAGTTACTCCT CTGTAAAAACTAAGAGTATTTATTTTACCAGTGCTGGATTACCAGTGTCATCTTCATATATGAAGAAGATTAAAATTTTATTGAAACATA TAAAACATAATTGATTTGGTAATAGTGGAAATAAACGATACCATCAAGATATGATTAAATAATTTAAAATCTATTTGTTAATTGATGGAA AACTTCAAACATGCATAAGAAGTTACTGTACTTATCACTCAGTTTCAATAATTTATCAATTCATTGCTAAAGTTCTTTCATGTAATACCC TCGCCCATTTCTTCCCTTTCTATATTACTTTGAAGCAAATACGTATTGTTTCTACTTGTAATGTAGTTAGTGTTTTATATACTTTTATGT AATATTATTACATTTTAATTGATATCTTATGTTTTTTATTTTATTTTATTTTATTTTCCTGAGACAGGGTCTCACTCTGTCACACAGGCT GGACTGCAGTGGCATCATCTTGGTTCACTGCAACCTCTGCCTCCCAGGCTCAAGTGATCCTCCCACCTCAGCCTCCTCAGTAGCTGGGAC TACAGGTGCATACCACCACACCCGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTTGCTGTGTTGCCCAGCTGGCCTCGAACTCCTG AGCCCAAGCGATACACCTGCCTTGGCCTCCCAGAGTGCTGAGATTACAGATGTGAGCCACTGTGTTCAGCTGATAAGTGTTTAAATTTCT CTAAAAACTATTTACTTATAAAGGTAAAAAAGATCTCTTTAGGCTTCAGTTTCACATATCTCCTTTAATCTTTTTTTAATAATTTCTAGT GATGGGATGATTAAGAGACTATTAAAGCTATTACCTCTTTAGAGTCATGTTCAAAATAATTATTAGATCTGAAAAGGGACTTGTGGGTTT TGTTGTTGTTGTTTATCCTTCTGCTTCTCCAATTTGTGTTGTAAATTCATGTTTAATTTTGTGTTCCCTCATTGCAGTTTATCAAAGTAC ATTCTGTATATTTTCTGTGGTTTTTTTCCTTCAGTTTTAATATTAAATTATTGGATTCTTTTTTTCAAAATCATTCTCAGCTTCCCAGGC AGACCCACTCAGTGATCCTGATCAGATGAACGAGGACAAGCGCCATTCACAGGGCACATTCACCAGTGACTACAGCAAGTATCTGGACTC CAGGCGTGCCCAAGATTTTGTGCAGTGGTTGATGAATACCAAGAGGAACAGGAATAACATTGCCAAACGTCACGATGAATTTGAGAGACA TGCTGAAGGGACCTTTACCAGTGATGTAAGTTCTTATTTGGAAGGCCAAGCTGCCAAGGAATTCATTGCTTGGCTGGTGAAAGGCCGAGG AAGGCGAGATTTCCCAGAAGAGGTCGCCATTGTTGAAGAACTTGGCCGCAGACATGCTGATGGTTCTTTCTCTGATGAGATGAACACCAT TCTTGATAATCTTGCCGCCAGGGACTTTATAAACTGGTTGATTCAGACCAAAATCACTGACAGGAAATAACTATATCACTATTCAAGATC ATCTTCACAACATCACCTGCTAGCCACGTGGGATGTTTGAAATGTTAAGTCCTGTAAATTTAAGAGGTGTATTCTGAGGCCACATTGCTT TGCATGCCAATAAATAAATTTTCTTTTAGTGTTGTGTAGCCAAAAATTACAAATGGAATAAAGTTTTATCAAAATATTGCTAAAATATCA GCTTTAAAATATGAAAGTGCTAGATTCTGTTATTTTCTTCTTATTTTGGATGAAGTACCCCAACCTGTTTACATTTAGCGATAAAATTAT TTTTCTATGATATAATTTGTAAATGTAAATTATTCCGATCTGACATATCTGCATTATAATAATAGGAGAATAGAAGAACTGGTAGCCACA GTGGTGAAATTGGAAAGAGAACTTTCTTCCTGAAACCTTTGTCTTAAAAATACTCAGCTTTCAATGTATCAAAGATACAATTAAATAAAA >66671_66671_2_PMS1-GCG_PMS1_chr2_190670480_ENST00000409985_GCG_chr2_163004024_ENST00000418842_length(amino acids)=134AA_BP= MNEDKRHSQGTFTSDYSKYLDSRRAQDFVQWLMNTKRNRNNIAKRHDEFERHAEGTFTSDVSSYLEGQAAKEFIAWLVKGRGRRDFPEEV -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for PMS1-GCG |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for PMS1-GCG |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for PMS1-GCG |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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