Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:PNKP-FZR1 (FusionGDB2 ID:66727)

Fusion Gene Summary for PNKP-FZR1

Fusion gene summary

Fusion gene information	Fusion gene name: PNKP-FZR1
	Fusion gene ID: 66727
		Hgene	Tgene
	Gene symbol	PNKP	FZR1
	Gene ID	11284	51343
	Gene name	polynucleotide kinase 3'-phosphatase	fizzy and cell division cycle 20 related 1
	Synonyms	AOA4\|EIEE10\|MCSZ\|PNK	CDC20C\|CDH1\|FZR\|FZR2\|HCDH\|HCDH1
	Cytomap	19q13.33	19p13.3
	Type of gene	protein-coding	protein-coding
	Description	bifunctional polynucleotide phosphatase/kinaseDNA 5'-kinase/3'-phosphataseHomo sapiens polynucleotide kinase 3'-phosphatase (PNKP)	fizzy-related protein homologCDC20 homolog 1CDC20-like 1bCDC20-like protein 1cdh1/Hct1 homologfizzy/cell division cycle 20 related 1
	Modification date	20200313	20200313
	UniProtAcc	.	Q9UM11
	Ensembl transtripts involved in fusion gene	ENST00000322344, ENST00000600573, ENST00000600910, ENST00000596014, ENST00000595792,	ENST00000313639, ENST00000395095, ENST00000441788,
Fusion gene scores	* DoF score	6 X 3 X 4=72	6 X 5 X 4=120
	# samples	6	6
	** MAII score	log2(6/72*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: PNKP [Title/Abstract] AND FZR1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	PNKP(50369656)-FZR1(3525866), # samples:1
Anticipated loss of major functional domain due to fusion event.	PNKP-FZR1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. PNKP-FZR1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. PNKP-FZR1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PNKP	GO:0006979	response to oxidative stress	10446192
Hgene	PNKP	GO:0016311	dephosphorylation	10446193
Hgene	PNKP	GO:0042769	DNA damage response, detection of DNA damage	10446192
Hgene	PNKP	GO:0046939	nucleotide phosphorylation	10446193
Tgene	FZR1	GO:0031145	anaphase-promoting complex-dependent catabolic process	18662541\|21596315
Tgene	FZR1	GO:0072425	signal transduction involved in G2 DNA damage checkpoint	18662541
Tgene	FZR1	GO:1904668	positive regulation of ubiquitin protein ligase activity	11459826

Fusion gene breakpoints across PNKP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across FZR1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-BR-A4PD-01A	PNKP	chr19	50369656	-	FZR1	chr19	3525866	+

Top

Fusion Gene ORF analysis for PNKP-FZR1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000322344	ENST00000313639	PNKP	chr19	50369656	-	FZR1	chr19	3525866	+
Frame-shift	ENST00000322344	ENST00000395095	PNKP	chr19	50369656	-	FZR1	chr19	3525866	+
Frame-shift	ENST00000322344	ENST00000441788	PNKP	chr19	50369656	-	FZR1	chr19	3525866	+
Frame-shift	ENST00000600573	ENST00000313639	PNKP	chr19	50369656	-	FZR1	chr19	3525866	+
Frame-shift	ENST00000600573	ENST00000395095	PNKP	chr19	50369656	-	FZR1	chr19	3525866	+
Frame-shift	ENST00000600573	ENST00000441788	PNKP	chr19	50369656	-	FZR1	chr19	3525866	+
Frame-shift	ENST00000600910	ENST00000313639	PNKP	chr19	50369656	-	FZR1	chr19	3525866	+
Frame-shift	ENST00000600910	ENST00000395095	PNKP	chr19	50369656	-	FZR1	chr19	3525866	+
Frame-shift	ENST00000600910	ENST00000441788	PNKP	chr19	50369656	-	FZR1	chr19	3525866	+
In-frame	ENST00000596014	ENST00000313639	PNKP	chr19	50369656	-	FZR1	chr19	3525866	+
In-frame	ENST00000596014	ENST00000395095	PNKP	chr19	50369656	-	FZR1	chr19	3525866	+
In-frame	ENST00000596014	ENST00000441788	PNKP	chr19	50369656	-	FZR1	chr19	3525866	+
intron-3CDS	ENST00000595792	ENST00000313639	PNKP	chr19	50369656	-	FZR1	chr19	3525866	+
intron-3CDS	ENST00000595792	ENST00000395095	PNKP	chr19	50369656	-	FZR1	chr19	3525866	+
intron-3CDS	ENST00000595792	ENST00000441788	PNKP	chr19	50369656	-	FZR1	chr19	3525866	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000596014	PNKP	chr19	50369656	-	ENST00000441788	FZR1	chr19	3525866	+	5187	280	58	1692	544
ENST00000596014	PNKP	chr19	50369656	-	ENST00000313639	FZR1	chr19	3525866	+	1426	280	58	1425	456
ENST00000596014	PNKP	chr19	50369656	-	ENST00000395095	FZR1	chr19	3525866	+	1702	280	58	1701	548

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000596014	ENST00000441788	PNKP	chr19	50369656	-	FZR1	chr19	3525866	+	0.03441717	0.96558285
ENST00000596014	ENST00000313639	PNKP	chr19	50369656	-	FZR1	chr19	3525866	+	0.12959912	0.87040085
ENST00000596014	ENST00000395095	PNKP	chr19	50369656	-	FZR1	chr19	3525866	+	0.06925461	0.93074536

Top

Fusion Genomic Features for PNKP-FZR1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
PNKP	chr19	50369655	-	FZR1	chr19	3525865	+	0.001547228	0.9984528
PNKP	chr19	50369655	-	FZR1	chr19	3525865	+	0.001547228	0.9984528

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for PNKP-FZR1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:50369656/chr19:3525866)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	FZR1 Q9UM11
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Substrate-specific adapter for the anaphase promoting complex/cyclosome (APC/C) E3 ubiquitin-protein ligase complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. Acts as an adapter for APC/C to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, may play a role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:25349192). {ECO:0000269\|PubMed:18662541, ECO:0000269\|PubMed:21596315, ECO:0000269\|PubMed:25349192, ECO:0000269\|PubMed:9734353}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

FZR1

chr19:50369656

chr19:3525866

ENST00000313639

47_52

405.0

Region

Involved in APC/FZR1 E3 ubiquitin-protein ligase complex activity

Tgene

FZR1

chr19:50369656

chr19:3525866

ENST00000395095

47_52

497.0

Region

Involved in APC/FZR1 E3 ubiquitin-protein ligase complex activity

Tgene

FZR1

chr19:50369656

chr19:3525866

ENST00000441788

47_52

494.0

Region

Involved in APC/FZR1 E3 ubiquitin-protein ligase complex activity

Tgene

FZR1

chr19:50369656

chr19:3525866

ENST00000313639

182_222

405.0

Repeat

Note=WD 1

Tgene

FZR1

chr19:50369656

chr19:3525866

ENST00000313639

227_266

405.0

Repeat

Note=WD 2

Tgene

FZR1

chr19:50369656

chr19:3525866

ENST00000313639

269_306

405.0

Repeat

Note=WD 3

Tgene

FZR1

chr19:50369656

chr19:3525866

ENST00000313639

311_350

405.0

Repeat

Note=WD 4

Tgene

FZR1

chr19:50369656

chr19:3525866

ENST00000313639

353_395

405.0

Repeat

Note=WD 5

Tgene

FZR1

chr19:50369656

chr19:3525866

ENST00000313639

397_438

405.0

Repeat

Note=WD 6

Tgene

FZR1

chr19:50369656

chr19:3525866

ENST00000313639

441_480

405.0

Repeat

Note=WD 7

Tgene

FZR1

chr19:50369656

chr19:3525866

ENST00000395095

182_222

497.0

Repeat

Note=WD 1

Tgene

FZR1

chr19:50369656

chr19:3525866

ENST00000395095

227_266

497.0

Repeat

Note=WD 2

Tgene

FZR1

chr19:50369656

chr19:3525866

ENST00000395095

269_306

497.0

Repeat

Note=WD 3

Tgene

FZR1

chr19:50369656

chr19:3525866

ENST00000395095

311_350

497.0

Repeat

Note=WD 4

Tgene

FZR1

chr19:50369656

chr19:3525866

ENST00000395095

353_395

497.0

Repeat

Note=WD 5

Tgene

FZR1

chr19:50369656

chr19:3525866

ENST00000395095

397_438

497.0

Repeat

Note=WD 6

Tgene

FZR1

chr19:50369656

chr19:3525866

ENST00000395095

441_480

497.0

Repeat

Note=WD 7

Tgene

FZR1

chr19:50369656

chr19:3525866

ENST00000441788

182_222

494.0

Repeat

Note=WD 1

Tgene

FZR1

chr19:50369656

chr19:3525866

ENST00000441788

227_266

494.0

Repeat

Note=WD 2

Tgene

FZR1

chr19:50369656

chr19:3525866

ENST00000441788

269_306

494.0

Repeat

Note=WD 3

Tgene

FZR1

chr19:50369656

chr19:3525866

ENST00000441788

311_350

494.0

Repeat

Note=WD 4

Tgene

FZR1

chr19:50369656

chr19:3525866

ENST00000441788

353_395

494.0

Repeat

Note=WD 5

Tgene

FZR1

chr19:50369656

chr19:3525866

ENST00000441788

397_438

494.0

Repeat

Note=WD 6

Tgene

FZR1

chr19:50369656

chr19:3525866

ENST00000441788

441_480

494.0

Repeat

Note=WD 7

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PNKP

chr19:50369656

chr19:3525866

ENST00000322344

6_110

522.0

Domain

Note=FHA

Hgene

PNKP

chr19:50369656

chr19:3525866

ENST00000596014

6_110

522.0

Domain

Note=FHA

Hgene

PNKP

chr19:50369656

chr19:3525866

ENST00000322344

372_379

522.0

Nucleotide binding

ATP

Hgene

PNKP

chr19:50369656

chr19:3525866

ENST00000596014

372_379

522.0

Nucleotide binding

ATP

Hgene

PNKP

chr19:50369656

chr19:3525866

ENST00000322344

146_337

522.0

Region

Phosphatase

Hgene

PNKP

chr19:50369656

chr19:3525866

ENST00000322344

341_516

522.0

Region

Kinase

Hgene

PNKP

chr19:50369656

chr19:3525866

ENST00000596014

146_337

522.0

Region

Phosphatase

Hgene

PNKP

chr19:50369656

chr19:3525866

ENST00000596014

341_516

522.0

Region

Kinase

Top

Fusion Gene Sequence for PNKP-FZR1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>66727_66727_1_PNKP-FZR1_PNKP_chr19_50369656_ENST00000596014_FZR1_chr19_3525866_ENST00000313639_length(transcript)=1426nt_BP=280nt
GGAGGAGGCGGGACTTCCTGCAGCAAATTGGGGCTGTGCGCCGCTCAAGCCCGTTTACCTGCTCCCCAGGCCGGCACCCAGGATGGGCGA
GGTGGAGGCCCCGGGCCGCTTGTGGCTCGAGAGCCCCCCTGGGGGAGCGCCCCCCATCTTCCTGCCCTCGGACGGGCAAGCCCTGGTCCT
GGGCAGGGGACCCCTGACCCAGGTTACGGACCGGAAGTGCTCCAGAACTCAAGTGGAGCTGGTCGCAGATCCTGAGACCCGGACAGTGGC
AGTGAAACAGGTCACAGAGATGCGGCGGACCCTGACGCCTGCCAGCTCCCCAGTGTCCTCGCCCAGCAAGCACGGAGACCGCTTCATCCC
CTCCAGAGCCGGAGCCAACTGGAGCGTGAACTTCCACAGGATTAACGAGAATGAGAAGTCTCCCAGTCAGAACCGGAAAGCCAAGGACGC
CACCTCAGACAACGGCAAAGACGGCCTGGCCTACTCTGCCCTGCTCAAGAATGAGCTGCTGGGTGCCGGCATCGAGAAGGTGCAGGACCC
GCAGACTGAGGACCGCAGGCTGCAGCCCTCCACGCCTGAGAAGAAGGGTCTGTTCACGGTGACGCGGCTCTGTGACCTCTCAGTGGAAGG
GGACTCAGTGACCTCCGTGGGCTGGTCTGAGCGGGGGAACCTGGTGGCGGTGGGCACACACAAGGGCTTCGTGCAGATCTGGGACGCAGC
CGCAGGGAAGAAGCTGTCCATGTTGGAGGGCCACACGGCACGCGTCGGGGCGCTGGCCTGGAATGCTGAGCAGCTGTCGTCCGGGAGCCG
CGACCGCATGATCCTGCAGAGGGACATCCGCACCCCGCCACTGCAGTCGGAGCGGCGGCTGCAGGGCCACCGGCAGGAGGTGTGCGGGCT
CAAGTGGTCCACAGACCACCAGCTCCTCGCCTCGGGGGGCAACGACAACAAGCTGCTGGTCTGGAATCACTCGAGCCTGAGCCCCGTGCA
GCAGTACACGGAGCACCTGGCGGCCGTGAAGGCCATCGCCTGGTCCCCACATCAGCACGGGCTGCTGGCCTCGGGGGGCGGCACAGCTGA
CCGCTGTATCCGCTTCTGGAACACGCTGACAGGACAACCACTGCAGTGTATCGACACGGGCTCCCAAGTGTGCAATCTGGCCTGGTCCAA
GCACGCCAACGAGCTGGTGAGCACGCACGGCTACTCACAGAACCAGATCCTTGTCTGGAAGTACCCCTCCCTGACCCAGGTGGCCAAGCT
GACCGGGCACTCCTACCGCGTGCTGTACCTGGCAATGTCCCCTGATGGGGAGGCCATCGTCACTGGTGCTGGAGACGAGACCCTGAGGTT

>66727_66727_1_PNKP-FZR1_PNKP_chr19_50369656_ENST00000596014_FZR1_chr19_3525866_ENST00000313639_length(amino acids)=456AA_BP=73
MLPRPAPRMGEVEAPGRLWLESPPGGAPPIFLPSDGQALVLGRGPLTQVTDRKCSRTQVELVADPETRTVAVKQVTEMRRTLTPASSPVS
SPSKHGDRFIPSRAGANWSVNFHRINENEKSPSQNRKAKDATSDNGKDGLAYSALLKNELLGAGIEKVQDPQTEDRRLQPSTPEKKGLFT
VTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQLSSGSRDRMILQRDIRTPPLQSERR
LQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDT
GSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKTRSTKESVSVLNL

--------------------------------------------------------------
>66727_66727_2_PNKP-FZR1_PNKP_chr19_50369656_ENST00000596014_FZR1_chr19_3525866_ENST00000395095_length(transcript)=1702nt_BP=280nt
GGAGGAGGCGGGACTTCCTGCAGCAAATTGGGGCTGTGCGCCGCTCAAGCCCGTTTACCTGCTCCCCAGGCCGGCACCCAGGATGGGCGA
GGTGGAGGCCCCGGGCCGCTTGTGGCTCGAGAGCCCCCCTGGGGGAGCGCCCCCCATCTTCCTGCCCTCGGACGGGCAAGCCCTGGTCCT
GGGCAGGGGACCCCTGACCCAGGTTACGGACCGGAAGTGCTCCAGAACTCAAGTGGAGCTGGTCGCAGATCCTGAGACCCGGACAGTGGC
AGTGAAACAGGTCACAGAGATGCGGCGGACCCTGACGCCTGCCAGCTCCCCAGTGTCCTCGCCCAGCAAGCACGGAGACCGCTTCATCCC
CTCCAGAGCCGGAGCCAACTGGAGCGTGAACTTCCACAGGATTAACGAGAATGAGAAGTCTCCCAGTCAGAACCGGAAAGCCAAGGACGC
CACCTCAGACAACGGCAAAGACGGCCTGGCCTACTCTGCCCTGCTCAAGAATGAGCTGCTGGGTGCCGGCATCGAGAAGGTGCAGGACCC
GCAGACTGAGGACCGCAGGCTGCAGCCCTCCACGCCTGAGAAGAAGGGTCTGTTCACGTATTCCCTTAGCACCAAGCGCTCCAGCCCCGA
TGACGGCAACGATGTGTCTCCCTACTCCCTGTCTCCCGTCAGCAACAAGAGCCAGAAGCTGCTCCGGTCCCCCCGGAAACCCACCCGCAA
GATCTCCAAGATCCCCTTCAAGGTGCTGGACGCGCCCGAGCTGCAGGACGACTTCTACCTCAATCTGGTGGACTGGTCGTCCCTCAATGT
GCTCAGCGTGGGGCTAGGCACCTGCGTGTACCTGTGGAGTGCCTGTACCAGCCAGGTGACGCGGCTCTGTGACCTCTCAGTGGAAGGGGA
CTCAGTGACCTCCGTGGGCTGGTCTGAGCGGGGGAACCTGGTGGCGGTGGGCACACACAAGGGCTTCGTGCAGATCTGGGACGCAGCCGC
AGGGAAGAAGCTGTCCATGTTGGAGGGCCACACGGCACGCGTCGGGGCGCTGGCCTGGAATGCTGAGCAGCTGTCGTCCGGGAGCCGCGA
CCGCATGATCCTGCAGAGGGACATCCGCACCCCGCCACTGCAGTCGGAGCGGCGGCTGCAGGGCCACCGGCAGGAGGTGTGCGGGCTCAA
GTGGTCCACAGACCACCAGCTCCTCGCCTCGGGGGGCAACGACAACAAGCTGCTGGTCTGGAATCACTCGAGCCTGAGCCCCGTGCAGCA
GTACACGGAGCACCTGGCGGCCGTGAAGGCCATCGCCTGGTCCCCACATCAGCACGGGCTGCTGGCCTCGGGGGGCGGCACAGCTGACCG
CTGTATCCGCTTCTGGAACACGCTGACAGGACAACCACTGCAGTGTATCGACACGGGCTCCCAAGTGTGCAATCTGGCCTGGTCCAAGCA
CGCCAACGAGCTGGTGAGCACGCACGGCTACTCACAGAACCAGATCCTTGTCTGGAAGTACCCCTCCCTGACCCAGGTGGCCAAGCTGAC
CGGGCACTCCTACCGCGTGCTGTACCTGGCAATGTCCCCTGATGGGGAGGCCATCGTCACTGGTGCTGGAGACGAGACCCTGAGGTTCTG

>66727_66727_2_PNKP-FZR1_PNKP_chr19_50369656_ENST00000596014_FZR1_chr19_3525866_ENST00000395095_length(amino acids)=548AA_BP=73
MLPRPAPRMGEVEAPGRLWLESPPGGAPPIFLPSDGQALVLGRGPLTQVTDRKCSRTQVELVADPETRTVAVKQVTEMRRTLTPASSPVS
SPSKHGDRFIPSRAGANWSVNFHRINENEKSPSQNRKAKDATSDNGKDGLAYSALLKNELLGAGIEKVQDPQTEDRRLQPSTPEKKGLFT
YSLSTKRSSPDDGNDVSPYSLSPVSNKSQKLLRSPRKPTRKISKIPFKVLDAPELQDDFYLNLVDWSSLNVLSVGLGTCVYLWSACTSQV
TRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQLSSGSRDRMILQRDIRTPPLQSERRL
QGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTG
SQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKTRSTKVKWESVSVL

--------------------------------------------------------------
>66727_66727_3_PNKP-FZR1_PNKP_chr19_50369656_ENST00000596014_FZR1_chr19_3525866_ENST00000441788_length(transcript)=5187nt_BP=280nt
GGAGGAGGCGGGACTTCCTGCAGCAAATTGGGGCTGTGCGCCGCTCAAGCCCGTTTACCTGCTCCCCAGGCCGGCACCCAGGATGGGCGA
GGTGGAGGCCCCGGGCCGCTTGTGGCTCGAGAGCCCCCCTGGGGGAGCGCCCCCCATCTTCCTGCCCTCGGACGGGCAAGCCCTGGTCCT
GGGCAGGGGACCCCTGACCCAGGTTACGGACCGGAAGTGCTCCAGAACTCAAGTGGAGCTGGTCGCAGATCCTGAGACCCGGACAGTGGC
AGTGAAACAGGTCACAGAGATGCGGCGGACCCTGACGCCTGCCAGCTCCCCAGTGTCCTCGCCCAGCAAGCACGGAGACCGCTTCATCCC
CTCCAGAGCCGGAGCCAACTGGAGCGTGAACTTCCACAGGATTAACGAGAATGAGAAGTCTCCCAGTCAGAACCGGAAAGCCAAGGACGC
CACCTCAGACAACGGCAAAGACGGCCTGGCCTACTCTGCCCTGCTCAAGAATGAGCTGCTGGGTGCCGGCATCGAGAAGGTGCAGGACCC
GCAGACTGAGGACCGCAGGCTGCAGCCCTCCACGCCTGAGAAGAAGGGTCTGTTCACGTATTCCCTTAGCACCAAGCGCTCCAGCCCCGA
TGACGGCAACGATGTGTCTCCCTACTCCCTGTCTCCCGTCAGCAACAAGAGCCAGAAGCTGCTCCGGTCCCCCCGGAAACCCACCCGCAA
GATCTCCAAGATCCCCTTCAAGGTGCTGGACGCGCCCGAGCTGCAGGACGACTTCTACCTCAATCTGGTGGACTGGTCGTCCCTCAATGT
GCTCAGCGTGGGGCTAGGCACCTGCGTGTACCTGTGGAGTGCCTGTACCAGCCAGGTGACGCGGCTCTGTGACCTCTCAGTGGAAGGGGA
CTCAGTGACCTCCGTGGGCTGGTCTGAGCGGGGGAACCTGGTGGCGGTGGGCACACACAAGGGCTTCGTGCAGATCTGGGACGCAGCCGC
AGGGAAGAAGCTGTCCATGTTGGAGGGCCACACGGCACGCGTCGGGGCGCTGGCCTGGAATGCTGAGCAGCTGTCGTCCGGGAGCCGCGA
CCGCATGATCCTGCAGAGGGACATCCGCACCCCGCCACTGCAGTCGGAGCGGCGGCTGCAGGGCCACCGGCAGGAGGTGTGCGGGCTCAA
GTGGTCCACAGACCACCAGCTCCTCGCCTCGGGGGGCAACGACAACAAGCTGCTGGTCTGGAATCACTCGAGCCTGAGCCCCGTGCAGCA
GTACACGGAGCACCTGGCGGCCGTGAAGGCCATCGCCTGGTCCCCACATCAGCACGGGCTGCTGGCCTCGGGGGGCGGCACAGCTGACCG
CTGTATCCGCTTCTGGAACACGCTGACAGGACAACCACTGCAGTGTATCGACACGGGCTCCCAAGTGTGCAATCTGGCCTGGTCCAAGCA
CGCCAACGAGCTGGTGAGCACGCACGGCTACTCACAGAACCAGATCCTTGTCTGGAAGTACCCCTCCCTGACCCAGGTGGCCAAGCTGAC
CGGGCACTCCTACCGCGTGCTGTACCTGGCAATGTCCCCTGATGGGGAGGCCATCGTCACTGGTGCTGGAGACGAGACCCTGAGGTTCTG
GAACGTCTTTAGCAAAACCCGTTCGACAAAGGAGTCTGTGTCTGTGCTCAACCTCTTCACCAGGATCCGGTAAACCTGCCGGGCAGGACC
GTGCCACACCAGCTGTCCAGAGTCGGAGGACCCCAGCTCCTCAGCTTGCATGGACTCTGCCTTCCCAGCGCTTGTCCCCCGAGGAAGGCG
GCTGGGCGGGCGGGGAGCTGGGCCTGGAGGATCCTGGAGTCTCATTAAATGCCTGATTGTGAACCATGTCCACCAGTATCTGGGGTGGGC
ACGTGGTCGGGGACCCTCAGCAGCAGGGGCTCTGTCTCCCTTCCCAAAGGGCGAGAACCACATTGGACGGTCCCGGCTCAGACCGTCTGT
ACTCAGAGCGACGGATGCCCCCTGGGACCCTCACTGCCTCCGTCTGTTCATCACCTGCCCACCGGAGCCGCATGCTCTTCCTGGAACTGC
CCACGTCTGCACAGAACAGACCACCAGACGCCAGGGCTGATTGGTGGGGGCCTGAGACCCCGGTTGCCCATTCATGGCTGCACCCCACCA
TGTCAAACCCAAGACCAGCCCCAAGGCCAGACCAAGGCATGTAGGCCTGGGCAGGTGGCTCGGGGCCACTGGCGGAGCCAGCCTGTGGAT
CCAAGAGACAGTCCCCACCTGGGCTTCACGGCATCCTTGCAGCCACCTCTGCTGTCACTGCTCGAAGCAGCAGTCTCTCTGGAAGCATCT
GTGTCATGGCCATCGCCCGGCGGTCAGTGGGCTTCAGATGGGCCTGTGCATCCTGGCCAAGCGTCACCCTCACACTGGAGGAGGATGTCT
GCTCTGGACTTATCACCCCAGGAGAACTGAACCCGGACCTGCTCACTGCCCTGGCTGGAGAGGAGCACAACAGATGCCACGTCTTCGTGC
ATTCGCCAACACGTGCCCTCACAGGGCCAGCGTCCTCCTTCCCTGCGCAAGACTTGCGTCCCCCATGCCTGCTGGGTGGCTGGGTCCTGT
GGAGGCCAGCAGCGGTGTGGCCCCCGCCCCCAGGCTGCCTGTGTCTTCACCTGTCCTGTCCACCAGCGCCAACAGCCGTGGGGAAGCCAA
GGAGACCCAAGGGGTCCAGGAGGTGGGCGCCCTCCATCCTTCGAGAAGCTTCCCAGGCTCCTCTGCTTCTCTGTCTCATGCTCCCAGGCT
GCACAGCAGGCAGGGAGGGAGGCAAGGCAGGGGAGTGGGGCCTGAGCTGAGCACTGCCCCCTCACCCCCCCACCACCCCTTCCCATTTCA
TCGGTGGGGACGTGGAGAGGGTGGGGCGGGCTGGGGTTGGAGGGTCCCACCCACCACCCTGCTGTGCTTGGGAACCCCCACTCCCCACTC
CCCACATCCCAACATCCTGGTGTCTGTCCCCAGTGGGGTTGGCGTGCATGTGTACATATGTATTTGTGACTTTTCTTTGGATTTGTTTTG
TGTTTTTGTTGACTAGTCCTGGAAATGTTTGAGGCTAGACGGGGAGGGGCCAGGACCCACCCACTGCTCCTGGGGGATGAGGTCCTGGTT
TTAAAGCCCCGTCATTTCAAGCGGGTCGATCTTCCACATTCACTGGAGAGACTCTCCCCACCTCTGTCTGGGTGGGGCGCGGACCCCTCA
CTGTGCGCCTGTGCAGGGGGTGCTGGTGCACGTGGCAGTGTGGATTTCCAGTGGTCACGGTCTTACTGTTTCAAGGTTTTTAAATAAGAA
AACCAACCCTGCCTTCGCCCATGCCCGCCCCTGCCCGCAGTTGCCAAAGAGCCGCCTTGTCGCTGTGGGCGTCAGGGCTTGGCTGGCTCA
GTGCACAACCCACAGTGGCCTTCAGAGGCTCCTCCTGGGACTGGGAACCGCCGCAGGGCCAGGCGGACGGCGTGAGGTTTGTGTTGGGGC
TGGTTCTGCCCATGCTAGGGGGTGGGGGAGCTCCCAGGACAGACCAGCCTTGTTTCTCATGTAATGCAGTGACGCTGTCATTAAACACGT
GGATTCATGTGTGGCCGGGACTGGCTGGCTCTAGGTCCCCGGCTCGGGTGGGGTCACACGGTCCTGCCCTAGAGTCCCCATCTGGCCCTG
GAGCTGCAGAAGCAGCTTCTGAGGGGCTTCCCAGGCCTGCATTTCACAGATGGGGAGCTCAGCCCTCGAAGGCCGCAGAGACGCCTCCCA
GGCCCGTCTGCCAGGGCGCCGGCCACAATCCTGCAGGGCCAAGGACTGGACTCCAGGCAAGTCCCTGCGCTCCAGCTGGACGGCCCTGTT
CCAGGGAGGAGGTGCTCGGTTGACACCATCAGGGAGGGAGGGTGGGCACTGCTGGGCTGAGTTCACCCCCAGGGCTGGCCAGATGGGGCC
AGGAGGGACAGAGCAAGGGGGGTGAAGGCCGTGGTGGGAGGGTCCCATGATGATGGGCCAGGGCTCGTGTAGAAATGGGGGAATTGGTTC
CCCATGGCCCAGGACAGCTGAGAGGAGGTGGAGGGGCCCCAGGGGAGTGTACGTCAGGCTTTGCGGGGCACGGGGGCCACTCAGCAGCGC
TGGGGCAGGTGCCTCTGCTGTCAGCTCCACCCGACAGGCAGACGAAGGCCAGTGGGGCCATCGCTTCCTGGGGCGACCCTGGCAGTGGTT
GGGAGACGCCCAGATGGAGGGGGAGGCTGACCAAGGGCCCCGCAGGGCGGGCTGCAACTTTTCTGTTGATCCTGGAATGTAGCTGGTGCA
GTGAGAGGGAAAGAGAATTGAAAAACTCAGGCTGCCATAGGTTCTGCGATGAGAGGTGCAGGAGGCAGGAGCCTGGCCCAGGGGGTGCTG
GTGCCTCCCCGGGGTCTGGGCGGAGAGAACAGGAGGAATGGCTGGGAAGTGGCTGAGGGAGCCAGGAGGCCGGGGGGCCGGGGGCTGCAG
GGGAGGCTGTGGGGGTCCTGGCAGCCAGGAGGCCCCAGGTGGTTTTGAGGCTCGCTCTTGCGCGGTGCCTGAGAAGAGGGTGAAGGAGCT
GGGGCAGGCCCCATCCTGGGCATTGGAGATGATGAAACCGAGCAGACCTGGCCCATGTGGAGCTGGCATGGGGGACACAGCCCAGAGACA
GAGAAGCTTATGAGGAAGTGAGGAGGTGGCGTCACAAGGGTGGGGAGGGGGCCTTGGGGAAGGGCGGCCTTGGATCAGAGGCTCACCACA
AGCCTGGCATTTCAGCCAGGGCTGGAGAAGGCAGGGACGCCTGGGTGAGAGGCAAAGGGCACAGCCATGCAAAGGCCCTGGGGCAGGACG
GCACCTGGTATGCGGGAGGAACAGAGTGAGGAGAGGAGGGCAGGGCGTGCAGGGCCTTGTGGGCCTCAGGGAGGACTTGGGCACCTACGC
CGAGGGAGTGGAGCTCCTGGGTGCGTGTCCAGATGGGAAAGGCAGGGTCGTATCTGTGGGGACCTGACAAGGGCAGGGGAAGCGGAGACC
AGGGTGCAGGCTCCGCCCCCACCCAAGGCCGGGCCCAGCCAGAGGAGGGGCAGGGCAGGGCAGGAGGTTTCTGGATGTTTGTTGGGTTTG

>66727_66727_3_PNKP-FZR1_PNKP_chr19_50369656_ENST00000596014_FZR1_chr19_3525866_ENST00000441788_length(amino acids)=544AA_BP=73
MLPRPAPRMGEVEAPGRLWLESPPGGAPPIFLPSDGQALVLGRGPLTQVTDRKCSRTQVELVADPETRTVAVKQVTEMRRTLTPASSPVS
SPSKHGDRFIPSRAGANWSVNFHRINENEKSPSQNRKAKDATSDNGKDGLAYSALLKNELLGAGIEKVQDPQTEDRRLQPSTPEKKGLFT
YSLSTKRSSPDDGNDVSPYSLSPVSNKSQKLLRSPRKPTRKISKIPFKVLDAPELQDDFYLNLVDWSSLNVLSVGLGTCVYLWSACTSQV
TRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQLSSGSRDRMILQRDIRTPPLQSERRL
QGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTG
SQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKTRSTKESVSVLNLF

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for PNKP-FZR1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for PNKP-FZR1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for PNKP-FZR1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source