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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PNPLA6-EXOSC10 (FusionGDB2 ID:66774)

Fusion Gene Summary for PNPLA6-EXOSC10

check button Fusion gene summary
Fusion gene informationFusion gene name: PNPLA6-EXOSC10
Fusion gene ID: 66774
HgeneTgene
Gene symbol

PNPLA6

EXOSC10

Gene ID

10908

5394

Gene namepatatin like phospholipase domain containing 6exosome component 10
SynonymsBNHS|LNMS|NTE|NTEMND|OMCS|SPG39|iPLA2delta|swsPM-Scl|PM/Scl-100|PMSCL|PMSCL2|RRP6|Rrp6p|p2|p3|p4
Cytomap

19p13.2

1p36.22

Type of geneprotein-codingprotein-coding
Descriptionneuropathy target esterasepatatin-like phospholipase domain-containing protein 6exosome component 10P100 polymyositis-scleroderma overlap syndrome-associated autoantigenautoantigen PM-SCLpolymyositis/scleroderma autoantigen 100 kDapolymyositis/scleroderma autoantigen 2
Modification date2020031320200313
UniProtAcc.

Q01780

Ensembl transtripts involved in fusion geneENST00000221249, ENST00000414982, 
ENST00000450331, ENST00000545201, 
ENST00000600737, ENST00000594864, 
ENST00000544779, ENST00000485606, 
ENST00000304457, ENST00000376936, 
Fusion gene scores* DoF score5 X 5 X 4=10010 X 11 X 7=770
# samples 516
** MAII scorelog2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/770*10)=-2.2667865406949
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PNPLA6 [Title/Abstract] AND EXOSC10 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPNPLA6(7606953)-EXOSC10(11137005), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PNPLA6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across EXOSC10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-16-0846-01APNPLA6chr19

7606953

+EXOSC10chr1

11137005

-


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Fusion Gene ORF analysis for PNPLA6-EXOSC10

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000221249ENST00000544779PNPLA6chr19

7606953

+EXOSC10chr1

11137005

-
5CDS-3UTRENST00000414982ENST00000544779PNPLA6chr19

7606953

+EXOSC10chr1

11137005

-
5CDS-3UTRENST00000450331ENST00000544779PNPLA6chr19

7606953

+EXOSC10chr1

11137005

-
5CDS-3UTRENST00000545201ENST00000544779PNPLA6chr19

7606953

+EXOSC10chr1

11137005

-
5CDS-3UTRENST00000600737ENST00000544779PNPLA6chr19

7606953

+EXOSC10chr1

11137005

-
5CDS-intronENST00000221249ENST00000485606PNPLA6chr19

7606953

+EXOSC10chr1

11137005

-
5CDS-intronENST00000414982ENST00000485606PNPLA6chr19

7606953

+EXOSC10chr1

11137005

-
5CDS-intronENST00000450331ENST00000485606PNPLA6chr19

7606953

+EXOSC10chr1

11137005

-
5CDS-intronENST00000545201ENST00000485606PNPLA6chr19

7606953

+EXOSC10chr1

11137005

-
5CDS-intronENST00000600737ENST00000485606PNPLA6chr19

7606953

+EXOSC10chr1

11137005

-
In-frameENST00000221249ENST00000304457PNPLA6chr19

7606953

+EXOSC10chr1

11137005

-
In-frameENST00000221249ENST00000376936PNPLA6chr19

7606953

+EXOSC10chr1

11137005

-
In-frameENST00000414982ENST00000304457PNPLA6chr19

7606953

+EXOSC10chr1

11137005

-
In-frameENST00000414982ENST00000376936PNPLA6chr19

7606953

+EXOSC10chr1

11137005

-
In-frameENST00000450331ENST00000304457PNPLA6chr19

7606953

+EXOSC10chr1

11137005

-
In-frameENST00000450331ENST00000376936PNPLA6chr19

7606953

+EXOSC10chr1

11137005

-
In-frameENST00000545201ENST00000304457PNPLA6chr19

7606953

+EXOSC10chr1

11137005

-
In-frameENST00000545201ENST00000376936PNPLA6chr19

7606953

+EXOSC10chr1

11137005

-
In-frameENST00000600737ENST00000304457PNPLA6chr19

7606953

+EXOSC10chr1

11137005

-
In-frameENST00000600737ENST00000376936PNPLA6chr19

7606953

+EXOSC10chr1

11137005

-
intron-3CDSENST00000594864ENST00000304457PNPLA6chr19

7606953

+EXOSC10chr1

11137005

-
intron-3CDSENST00000594864ENST00000376936PNPLA6chr19

7606953

+EXOSC10chr1

11137005

-
intron-3UTRENST00000594864ENST00000544779PNPLA6chr19

7606953

+EXOSC10chr1

11137005

-
intron-intronENST00000594864ENST00000485606PNPLA6chr19

7606953

+EXOSC10chr1

11137005

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000221249PNPLA6chr197606953+ENST00000304457EXOSC10chr111137005-237015664312269612
ENST00000221249PNPLA6chr197606953+ENST00000376936EXOSC10chr111137005-244515664312344637
ENST00000545201PNPLA6chr197606953+ENST00000304457EXOSC10chr111137005-233915354002238612
ENST00000545201PNPLA6chr197606953+ENST00000376936EXOSC10chr111137005-241415354002313637
ENST00000414982PNPLA6chr197606953+ENST00000304457EXOSC10chr111137005-227814741952177660
ENST00000414982PNPLA6chr197606953+ENST00000376936EXOSC10chr111137005-235314741952252685
ENST00000450331PNPLA6chr197606953+ENST00000304457EXOSC10chr111137005-221014061992109636
ENST00000450331PNPLA6chr197606953+ENST00000376936EXOSC10chr111137005-228514061992184661
ENST00000600737PNPLA6chr197606953+ENST00000304457EXOSC10chr111137005-21391335142038674
ENST00000600737PNPLA6chr197606953+ENST00000376936EXOSC10chr111137005-22141335142113699

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000221249ENST00000304457PNPLA6chr197606953+EXOSC10chr111137005-0.0117335150.9882665
ENST00000221249ENST00000376936PNPLA6chr197606953+EXOSC10chr111137005-0.0140808020.98591924
ENST00000545201ENST00000304457PNPLA6chr197606953+EXOSC10chr111137005-0.0095050340.99049497
ENST00000545201ENST00000376936PNPLA6chr197606953+EXOSC10chr111137005-0.0117318570.9882682
ENST00000414982ENST00000304457PNPLA6chr197606953+EXOSC10chr111137005-0.0139803520.98601973
ENST00000414982ENST00000376936PNPLA6chr197606953+EXOSC10chr111137005-0.0133518580.98664814
ENST00000450331ENST00000304457PNPLA6chr197606953+EXOSC10chr111137005-0.0122092030.9877908
ENST00000450331ENST00000376936PNPLA6chr197606953+EXOSC10chr111137005-0.0149044320.98509556
ENST00000600737ENST00000304457PNPLA6chr197606953+EXOSC10chr111137005-0.0093341050.99066585
ENST00000600737ENST00000376936PNPLA6chr197606953+EXOSC10chr111137005-0.0092309320.9907691

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Fusion Genomic Features for PNPLA6-EXOSC10


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PNPLA6-EXOSC10


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:7606953/chr1:11137005)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.EXOSC10

Q01780

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 has 3'-5' exonuclease activity (By similarity). EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of MTREX, C1D and MPP6 wth the RNA exosome involved in the maturation of 5.8S rRNA. {ECO:0000250, ECO:0000269|PubMed:14527413, ECO:0000269|PubMed:16455498, ECO:0000269|PubMed:17412707, ECO:0000269|PubMed:17545563, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:19056938, ECO:0000269|PubMed:20368444, ECO:0000269|PubMed:20699273}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePNPLA6chr19:7606953chr1:11137005ENST00000221249+1335195_3223781328.0Nucleotide bindingNote=cNMP 1
HgenePNPLA6chr19:7606953chr1:11137005ENST00000414982+1234195_3224261376.0Nucleotide bindingNote=cNMP 1
HgenePNPLA6chr19:7606953chr1:11137005ENST00000450331+1335195_3223781328.0Nucleotide bindingNote=cNMP 1
HgenePNPLA6chr19:7606953chr1:11137005ENST00000545201+1334195_3223781301.0Nucleotide bindingNote=cNMP 1
HgenePNPLA6chr19:7606953chr1:11137005ENST00000600737+1032195_3224171366.0Nucleotide bindingNote=cNMP 1
HgenePNPLA6chr19:7606953chr1:11137005ENST00000221249+13351_593781328.0Topological domainLumenal
HgenePNPLA6chr19:7606953chr1:11137005ENST00000414982+12341_594261376.0Topological domainLumenal
HgenePNPLA6chr19:7606953chr1:11137005ENST00000450331+13351_593781328.0Topological domainLumenal
HgenePNPLA6chr19:7606953chr1:11137005ENST00000545201+13341_593781301.0Topological domainLumenal
HgenePNPLA6chr19:7606953chr1:11137005ENST00000600737+10321_594171366.0Topological domainLumenal
HgenePNPLA6chr19:7606953chr1:11137005ENST00000221249+133560_803781328.0TransmembraneHelical
HgenePNPLA6chr19:7606953chr1:11137005ENST00000414982+123460_804261376.0TransmembraneHelical
HgenePNPLA6chr19:7606953chr1:11137005ENST00000450331+133560_803781328.0TransmembraneHelical
HgenePNPLA6chr19:7606953chr1:11137005ENST00000545201+133460_803781301.0TransmembraneHelical
HgenePNPLA6chr19:7606953chr1:11137005ENST00000600737+103260_804171366.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePNPLA6chr19:7606953chr1:11137005ENST00000221249+1335981_11473781328.0DomainPNPLA
HgenePNPLA6chr19:7606953chr1:11137005ENST00000414982+1234981_11474261376.0DomainPNPLA
HgenePNPLA6chr19:7606953chr1:11137005ENST00000450331+1335981_11473781328.0DomainPNPLA
HgenePNPLA6chr19:7606953chr1:11137005ENST00000545201+1334981_11473781301.0DomainPNPLA
HgenePNPLA6chr19:7606953chr1:11137005ENST00000600737+1032981_11474171366.0DomainPNPLA
HgenePNPLA6chr19:7606953chr1:11137005ENST00000221249+13351012_10163781328.0MotifGXSXG
HgenePNPLA6chr19:7606953chr1:11137005ENST00000221249+13351134_11363781328.0MotifDGA/G
HgenePNPLA6chr19:7606953chr1:11137005ENST00000221249+1335985_9903781328.0MotifGXGXXG
HgenePNPLA6chr19:7606953chr1:11137005ENST00000414982+12341012_10164261376.0MotifGXSXG
HgenePNPLA6chr19:7606953chr1:11137005ENST00000414982+12341134_11364261376.0MotifDGA/G
HgenePNPLA6chr19:7606953chr1:11137005ENST00000414982+1234985_9904261376.0MotifGXGXXG
HgenePNPLA6chr19:7606953chr1:11137005ENST00000450331+13351012_10163781328.0MotifGXSXG
HgenePNPLA6chr19:7606953chr1:11137005ENST00000450331+13351134_11363781328.0MotifDGA/G
HgenePNPLA6chr19:7606953chr1:11137005ENST00000450331+1335985_9903781328.0MotifGXGXXG
HgenePNPLA6chr19:7606953chr1:11137005ENST00000545201+13341012_10163781301.0MotifGXSXG
HgenePNPLA6chr19:7606953chr1:11137005ENST00000545201+13341134_11363781301.0MotifDGA/G
HgenePNPLA6chr19:7606953chr1:11137005ENST00000545201+1334985_9903781301.0MotifGXGXXG
HgenePNPLA6chr19:7606953chr1:11137005ENST00000600737+10321012_10164171366.0MotifGXSXG
HgenePNPLA6chr19:7606953chr1:11137005ENST00000600737+10321134_11364171366.0MotifDGA/G
HgenePNPLA6chr19:7606953chr1:11137005ENST00000600737+1032985_9904171366.0MotifGXGXXG
HgenePNPLA6chr19:7606953chr1:11137005ENST00000221249+1335511_6333781328.0Nucleotide bindingNote=cNMP 2
HgenePNPLA6chr19:7606953chr1:11137005ENST00000221249+1335629_7493781328.0Nucleotide bindingNote=cNMP 3
HgenePNPLA6chr19:7606953chr1:11137005ENST00000414982+1234511_6334261376.0Nucleotide bindingNote=cNMP 2
HgenePNPLA6chr19:7606953chr1:11137005ENST00000414982+1234629_7494261376.0Nucleotide bindingNote=cNMP 3
HgenePNPLA6chr19:7606953chr1:11137005ENST00000450331+1335511_6333781328.0Nucleotide bindingNote=cNMP 2
HgenePNPLA6chr19:7606953chr1:11137005ENST00000450331+1335629_7493781328.0Nucleotide bindingNote=cNMP 3
HgenePNPLA6chr19:7606953chr1:11137005ENST00000545201+1334511_6333781301.0Nucleotide bindingNote=cNMP 2
HgenePNPLA6chr19:7606953chr1:11137005ENST00000545201+1334629_7493781301.0Nucleotide bindingNote=cNMP 3
HgenePNPLA6chr19:7606953chr1:11137005ENST00000600737+1032511_6334171366.0Nucleotide bindingNote=cNMP 2
HgenePNPLA6chr19:7606953chr1:11137005ENST00000600737+1032629_7494171366.0Nucleotide bindingNote=cNMP 3
HgenePNPLA6chr19:7606953chr1:11137005ENST00000221249+133581_13753781328.0Topological domainCytoplasmic
HgenePNPLA6chr19:7606953chr1:11137005ENST00000414982+123481_13754261376.0Topological domainCytoplasmic
HgenePNPLA6chr19:7606953chr1:11137005ENST00000450331+133581_13753781328.0Topological domainCytoplasmic
HgenePNPLA6chr19:7606953chr1:11137005ENST00000545201+133481_13753781301.0Topological domainCytoplasmic
HgenePNPLA6chr19:7606953chr1:11137005ENST00000600737+103281_13754171366.0Topological domainCytoplasmic
TgeneEXOSC10chr19:7606953chr1:11137005ENST000003044571524503_583626861.0DomainHRDC
TgeneEXOSC10chr19:7606953chr1:11137005ENST000003769361525503_583626886.0DomainHRDC


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Fusion Gene Sequence for PNPLA6-EXOSC10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>66774_66774_1_PNPLA6-EXOSC10_PNPLA6_chr19_7606953_ENST00000221249_EXOSC10_chr1_11137005_ENST00000304457_length(transcript)=2370nt_BP=1566nt
TTTTTAGCGGGAGGAGCAGTCCTTGCGTTAAGCGGTGTGAGGCCCTTTAAGGCGCGGCCACACTCAGCATGGCGGCCTCAGTCGGCCTTC
CAAGCATGGCGCGGGGAGGAGGGGTGGGAGGGTCGGGAGGGACTGCGGTGCGACTAGGAGTGAATAATTTAAAGGGGCCGTGCCTGCGGA
GCCGGGCGGAACGCTAGCGGTGTTGGCGCGGAGTGGACCCCGGCTGCGGCCCCTGGCAATGGCGCCACCATCGGTCCCGGAGTCCCAGTG
ATGCTCTGTGCCATAGAGCCCCCATAACTTCACTACTACGTGATAGTAAATCCCCGGCAAAAACCAGCAGCGCCTTGCAAGCCCACGCCA
CCCCAAGCATCCCAGGACTCTTCTGAAACGACTCCGGGCTACCAGATCGGCCGTCCAGCTGGAATCAACCGATGGAGGCTCCGCTGCAAA
CTGGAATGGTGCTTGGCGTGATGATCGGGGCCGGAGTGGCGGTGGTGGTCACGGCCGTGCTCATCCTCCTGGTGGTGCGGAGGCTGCGAG
TGCCAAAAACCCCAGCCCCGGATGGCCCCCGGTATCGGTTCCGGAAGAGGGACAAAGTGCTCTTCTATGGCCGGAAGATTATGCGGAAGG
TGTCACAATCCACCTCCTCCCTCGTGGATACCTCTGTCTCCGCCACCTCCCGGCCACGCATGAGGAAGAAACTGAAGATGCTCAACATTG
CCAAGAAGATCCTGCGCATCCAGAAAGAGACGCCCACGCTGCAGCGGAAGGAGCCCCCGCCCGCAGTGCTAGAAGCTGACCTGACCGAGG
GCGACCTGGCTAACTCCCATCTGCCCTCTGAAGTGCTTTATATGCTCAAGAACGTCCGGGTGCTGGGCCACTTCGAGAAGCCACTCTTCC
TGGAGCTCTGCCGCCACATGGTCTTCCAGCGGCTGGGCCAGGGTGACTACGTCTTCCGGCCGGGCCAGCCAGATGCCAGCATCTACGTGG
TGCAGGACGGGCTGCTGGAGCTCTGTCTGCCAGGGCCTGACGGGAAGGAGTGTGTGGTGAAGGAAGTGGTTCCTGGGGACAGCGTCAACA
GCCTTCTCAGCATCCTGGATGTCATCACCGGTCACCAGCATCCCCAGCGGACCGTGTCTGCCCGGGCGGCCCGGGACTCCACGGTGCTGC
GCCTGCCGGTGGAAGCATTCTCCGCGGTCTTCACCAAGTACCCGGAGAGCTTGGTGCGGGTCGTGCAGATCATCATGGTGCGGCTGCAGC
GAGTCACCTTCCTGGCACTGCACAACTACCTGGGTCTGACCAATGAGCTCTTCAGCCACGAGATCCAGCCCCTGCGTCTGTTCCCCAGCC
CCGGCCTCCCAACTCGCACCAGCCCTGTGCGGGGCTCCAAGAGAATGGTCAGCACCTCAGCTACAGACGAGCCCAGGGAGACCCCAGGGC
GGCCACCCGATCCCACCGGGGCCCCGCTGCCTGGACCTACAGGGGACCCTGTGAAGCCCACATCCCTGGAAACCCCCTCGGCCCCTCTGC
TGAGCCGCTGCGTCTCCATGCCAGGGGACATCTCAGGATCTGTGCCAGTTCAGAAGCAGGCGAGCCTCTTCCCTGATGAAAAAGAAGATA
ACTTGCTGGGTACCACATGCCTGATTGCCACAGCTGTCATCACGTTATTTAATGAACCTAGTGCTGAAGACAGTAAAAAGGGTCCATTGA
CAGTTGCACAGAAAAAAGCCCAGAACATCATGGAGTCCTTTGAAAATCCATTTAGGATGATCAGCAACCGCTGGAAGCTGGCCCAGGTAC
AAGTACAAAAAGACTCTAAAGAAGCTGTCAAGAAGAAGGCAGCTGAGCAAACAGCTGCCCGGGAACAGGCAAAGGAGGCGTGCAAAGCTG
CAGCAGAACAGGCCATCTCCGTCCGACAGCAGGTCGTGCTAGAAAATGCTGCAAAGAAGAGAGAGCGAGCAACAAGCGACCCAAGGACCA
CAGAACAGAAACAAGAGAAGAAACGACTCAAAATTTCCAAGAAGCCAAAGGACCCAGAGCCACCAGAAAAAGAGTTTACGCCTTACGACT
ACAGCCAGTCAGACTTCAAGGCTTTTGCTGGAAACAGCAAATCCAAAGTTTCTTCTCAGTTTGATCCAAATAAACAGACCCCGTCTGGCA
AGAAATGCATTGCAGCCAAAAAAATTAAACAGTCGGTGGGAAACAAAAGCATGTCCTTTCCAACTGGAAAGTCAGACAGAGGCTTCAGGT
ACAACTGGCCACAGAGATAGTCCTGGAAGACACGTGGCGCCTGTGGACCGGAAGCACCAAATGCTGGTGCTGCTTTTGTACATACATATT

>66774_66774_1_PNPLA6-EXOSC10_PNPLA6_chr19_7606953_ENST00000221249_EXOSC10_chr1_11137005_ENST00000304457_length(amino acids)=612AA_BP=378
MEAPLQTGMVLGVMIGAGVAVVVTAVLILLVVRRLRVPKTPAPDGPRYRFRKRDKVLFYGRKIMRKVSQSTSSLVDTSVSATSRPRMRKK
LKMLNIAKKILRIQKETPTLQRKEPPPAVLEADLTEGDLANSHLPSEVLYMLKNVRVLGHFEKPLFLELCRHMVFQRLGQGDYVFRPGQP
DASIYVVQDGLLELCLPGPDGKECVVKEVVPGDSVNSLLSILDVITGHQHPQRTVSARAARDSTVLRLPVEAFSAVFTKYPESLVRVVQI
IMVRLQRVTFLALHNYLGLTNELFSHEIQPLRLFPSPGLPTRTSPVRGSKRMVSTSATDEPRETPGRPPDPTGAPLPGPTGDPVKPTSLE
TPSAPLLSRCVSMPGDISGSVPVQKQASLFPDEKEDNLLGTTCLIATAVITLFNEPSAEDSKKGPLTVAQKKAQNIMESFENPFRMISNR
WKLAQVQVQKDSKEAVKKKAAEQTAAREQAKEACKAAAEQAISVRQQVVLENAAKKRERATSDPRTTEQKQEKKRLKISKKPKDPEPPEK

--------------------------------------------------------------
>66774_66774_2_PNPLA6-EXOSC10_PNPLA6_chr19_7606953_ENST00000221249_EXOSC10_chr1_11137005_ENST00000376936_length(transcript)=2445nt_BP=1566nt
TTTTTAGCGGGAGGAGCAGTCCTTGCGTTAAGCGGTGTGAGGCCCTTTAAGGCGCGGCCACACTCAGCATGGCGGCCTCAGTCGGCCTTC
CAAGCATGGCGCGGGGAGGAGGGGTGGGAGGGTCGGGAGGGACTGCGGTGCGACTAGGAGTGAATAATTTAAAGGGGCCGTGCCTGCGGA
GCCGGGCGGAACGCTAGCGGTGTTGGCGCGGAGTGGACCCCGGCTGCGGCCCCTGGCAATGGCGCCACCATCGGTCCCGGAGTCCCAGTG
ATGCTCTGTGCCATAGAGCCCCCATAACTTCACTACTACGTGATAGTAAATCCCCGGCAAAAACCAGCAGCGCCTTGCAAGCCCACGCCA
CCCCAAGCATCCCAGGACTCTTCTGAAACGACTCCGGGCTACCAGATCGGCCGTCCAGCTGGAATCAACCGATGGAGGCTCCGCTGCAAA
CTGGAATGGTGCTTGGCGTGATGATCGGGGCCGGAGTGGCGGTGGTGGTCACGGCCGTGCTCATCCTCCTGGTGGTGCGGAGGCTGCGAG
TGCCAAAAACCCCAGCCCCGGATGGCCCCCGGTATCGGTTCCGGAAGAGGGACAAAGTGCTCTTCTATGGCCGGAAGATTATGCGGAAGG
TGTCACAATCCACCTCCTCCCTCGTGGATACCTCTGTCTCCGCCACCTCCCGGCCACGCATGAGGAAGAAACTGAAGATGCTCAACATTG
CCAAGAAGATCCTGCGCATCCAGAAAGAGACGCCCACGCTGCAGCGGAAGGAGCCCCCGCCCGCAGTGCTAGAAGCTGACCTGACCGAGG
GCGACCTGGCTAACTCCCATCTGCCCTCTGAAGTGCTTTATATGCTCAAGAACGTCCGGGTGCTGGGCCACTTCGAGAAGCCACTCTTCC
TGGAGCTCTGCCGCCACATGGTCTTCCAGCGGCTGGGCCAGGGTGACTACGTCTTCCGGCCGGGCCAGCCAGATGCCAGCATCTACGTGG
TGCAGGACGGGCTGCTGGAGCTCTGTCTGCCAGGGCCTGACGGGAAGGAGTGTGTGGTGAAGGAAGTGGTTCCTGGGGACAGCGTCAACA
GCCTTCTCAGCATCCTGGATGTCATCACCGGTCACCAGCATCCCCAGCGGACCGTGTCTGCCCGGGCGGCCCGGGACTCCACGGTGCTGC
GCCTGCCGGTGGAAGCATTCTCCGCGGTCTTCACCAAGTACCCGGAGAGCTTGGTGCGGGTCGTGCAGATCATCATGGTGCGGCTGCAGC
GAGTCACCTTCCTGGCACTGCACAACTACCTGGGTCTGACCAATGAGCTCTTCAGCCACGAGATCCAGCCCCTGCGTCTGTTCCCCAGCC
CCGGCCTCCCAACTCGCACCAGCCCTGTGCGGGGCTCCAAGAGAATGGTCAGCACCTCAGCTACAGACGAGCCCAGGGAGACCCCAGGGC
GGCCACCCGATCCCACCGGGGCCCCGCTGCCTGGACCTACAGGGGACCCTGTGAAGCCCACATCCCTGGAAACCCCCTCGGCCCCTCTGC
TGAGCCGCTGCGTCTCCATGCCAGGGGACATCTCAGGATCTGTGCCAGTTCAGAAGCAGGCGAGCCTCTTCCCTGATGAAAAAGAAGATA
ACTTGCTGGGTACCACATGCCTGATTGCCACAGCTGTCATCACGTTATTTAATGAACCTAGTGCTGAAGACAGTAAAAAGGGTCCATTGA
CAGTTGCACAGAAAAAAGCCCAGAACATCATGGAGTCCTTTGAAAATCCATTTAGGATGTTTCTGCCCTCACTGGGACACCGTGCTCCCG
TCTCTCAGGCAGCGAAGTTCGATCCATCAACCAAAATCTATGAAATCAGCAACCGCTGGAAGCTGGCCCAGGTACAAGTACAAAAAGACT
CTAAAGAAGCTGTCAAGAAGAAGGCAGCTGAGCAAACAGCTGCCCGGGAACAGGCAAAGGAGGCGTGCAAAGCTGCAGCAGAACAGGCCA
TCTCCGTCCGACAGCAGGTCGTGCTAGAAAATGCTGCAAAGAAGAGAGAGCGAGCAACAAGCGACCCAAGGACCACAGAACAGAAACAAG
AGAAGAAACGACTCAAAATTTCCAAGAAGCCAAAGGACCCAGAGCCACCAGAAAAAGAGTTTACGCCTTACGACTACAGCCAGTCAGACT
TCAAGGCTTTTGCTGGAAACAGCAAATCCAAAGTTTCTTCTCAGTTTGATCCAAATAAACAGACCCCGTCTGGCAAGAAATGCATTGCAG
CCAAAAAAATTAAACAGTCGGTGGGAAACAAAAGCATGTCCTTTCCAACTGGAAAGTCAGACAGAGGCTTCAGGTACAACTGGCCACAGA
GATAGTCCTGGAAGACACGTGGCGCCTGTGGACCGGAAGCACCAAATGCTGGTGCTGCTTTTGTACATACATATTTTTAAACCATTAAAA

>66774_66774_2_PNPLA6-EXOSC10_PNPLA6_chr19_7606953_ENST00000221249_EXOSC10_chr1_11137005_ENST00000376936_length(amino acids)=637AA_BP=378
MEAPLQTGMVLGVMIGAGVAVVVTAVLILLVVRRLRVPKTPAPDGPRYRFRKRDKVLFYGRKIMRKVSQSTSSLVDTSVSATSRPRMRKK
LKMLNIAKKILRIQKETPTLQRKEPPPAVLEADLTEGDLANSHLPSEVLYMLKNVRVLGHFEKPLFLELCRHMVFQRLGQGDYVFRPGQP
DASIYVVQDGLLELCLPGPDGKECVVKEVVPGDSVNSLLSILDVITGHQHPQRTVSARAARDSTVLRLPVEAFSAVFTKYPESLVRVVQI
IMVRLQRVTFLALHNYLGLTNELFSHEIQPLRLFPSPGLPTRTSPVRGSKRMVSTSATDEPRETPGRPPDPTGAPLPGPTGDPVKPTSLE
TPSAPLLSRCVSMPGDISGSVPVQKQASLFPDEKEDNLLGTTCLIATAVITLFNEPSAEDSKKGPLTVAQKKAQNIMESFENPFRMFLPS
LGHRAPVSQAAKFDPSTKIYEISNRWKLAQVQVQKDSKEAVKKKAAEQTAAREQAKEACKAAAEQAISVRQQVVLENAAKKRERATSDPR
TTEQKQEKKRLKISKKPKDPEPPEKEFTPYDYSQSDFKAFAGNSKSKVSSQFDPNKQTPSGKKCIAAKKIKQSVGNKSMSFPTGKSDRGF

--------------------------------------------------------------
>66774_66774_3_PNPLA6-EXOSC10_PNPLA6_chr19_7606953_ENST00000414982_EXOSC10_chr1_11137005_ENST00000304457_length(transcript)=2278nt_BP=1474nt
CAATGGCGCCACCATCGGTCCCGGAGTCCCAGTGATGCTCTGTGCCATAGAGCCCCCATAACTTCACTACTACGTGATAGTAAATCCCCG
GCAAAAACCAGCAGCGCCTTGCAAGCCCACGCCACCCCAAGCATCCCAGGACTCTTCTGAAACGACTCCGGGCTACCAGATCGGCCGTCC
AGCTGGAATCAACCGATGGAGGCTCCGCTGCAAACTGGAATGATGGGGACATCGAGTCACGGGCTGGCTACGAACTCCTCGGGGGCGAAG
GTGGCGGAGAGGGATGGGTTCCAGGACGTCCTGGCGCCCGGGGAAGGCTCGGCGGGACGGATTTGCGGTGCGCAGCCAGTGCCGTTCGTC
CCTCAGGTGCTTGGCGTGATGATCGGGGCCGGAGTGGCGGTGGTGGTCACGGCCGTGCTCATCCTCCTGGTGGTGCGGAGGCTGCGAGTG
CCAAAAACCCCAGCCCCGGATGGCCCCCGGTATCGGTTCCGGAAGAGGGACAAAGTGCTCTTCTATGGCCGGAAGATTATGCGGAAGGTG
TCACAATCCACCTCCTCCCTCGTGGATACCTCTGTCTCCGCCACCTCCCGGCCACGCATGAGGAAGAAACTGAAGATGCTCAACATTGCC
AAGAAGATCCTGCGCATCCAGAAAGAGACGCCCACGCTGCAGCGGAAGGAGCCCCCGCCCGCAGTGCTAGAAGCTGACCTGACCGAGGGC
GACCTGGCTAACTCCCATCTGCCCTCTGAAGTGCTTTATATGCTCAAGAACGTCCGGGTGCTGGGCCACTTCGAGAAGCCACTCTTCCTG
GAGCTCTGCCGCCACATGGTCTTCCAGCGGCTGGGCCAGGGTGACTACGTCTTCCGGCCGGGCCAGCCAGATGCCAGCATCTACGTGGTG
CAGGACGGGCTGCTGGAGCTCTGTCTGCCAGGGCCTGACGGGAAGGAGTGTGTGGTGAAGGAAGTGGTTCCTGGGGACAGCGTCAACAGC
CTTCTCAGCATCCTGGATGTCATCACCGGTCACCAGCATCCCCAGCGGACCGTGTCTGCCCGGGCGGCCCGGGACTCCACGGTGCTGCGC
CTGCCGGTGGAAGCATTCTCCGCGGTCTTCACCAAGTACCCGGAGAGCTTGGTGCGGGTCGTGCAGATCATCATGGTGCGGCTGCAGCGA
GTCACCTTCCTGGCACTGCACAACTACCTGGGTCTGACCAATGAGCTCTTCAGCCACGAGATCCAGCCCCTGCGTCTGTTCCCCAGCCCC
GGCCTCCCAACTCGCACCAGCCCTGTGCGGGGCTCCAAGAGAATGGTCAGCACCTCAGCTACAGACGAGCCCAGGGAGACCCCAGGGCGG
CCACCCGATCCCACCGGGGCCCCGCTGCCTGGACCTACAGGGGACCCTGTGAAGCCCACATCCCTGGAAACCCCCTCGGCCCCTCTGCTG
AGCCGCTGCGTCTCCATGCCAGGGGACATCTCAGGATCTGTGCCAGTTCAGAAGCAGGCGAGCCTCTTCCCTGATGAAAAAGAAGATAAC
TTGCTGGGTACCACATGCCTGATTGCCACAGCTGTCATCACGTTATTTAATGAACCTAGTGCTGAAGACAGTAAAAAGGGTCCATTGACA
GTTGCACAGAAAAAAGCCCAGAACATCATGGAGTCCTTTGAAAATCCATTTAGGATGATCAGCAACCGCTGGAAGCTGGCCCAGGTACAA
GTACAAAAAGACTCTAAAGAAGCTGTCAAGAAGAAGGCAGCTGAGCAAACAGCTGCCCGGGAACAGGCAAAGGAGGCGTGCAAAGCTGCA
GCAGAACAGGCCATCTCCGTCCGACAGCAGGTCGTGCTAGAAAATGCTGCAAAGAAGAGAGAGCGAGCAACAAGCGACCCAAGGACCACA
GAACAGAAACAAGAGAAGAAACGACTCAAAATTTCCAAGAAGCCAAAGGACCCAGAGCCACCAGAAAAAGAGTTTACGCCTTACGACTAC
AGCCAGTCAGACTTCAAGGCTTTTGCTGGAAACAGCAAATCCAAAGTTTCTTCTCAGTTTGATCCAAATAAACAGACCCCGTCTGGCAAG
AAATGCATTGCAGCCAAAAAAATTAAACAGTCGGTGGGAAACAAAAGCATGTCCTTTCCAACTGGAAAGTCAGACAGAGGCTTCAGGTAC
AACTGGCCACAGAGATAGTCCTGGAAGACACGTGGCGCCTGTGGACCGGAAGCACCAAATGCTGGTGCTGCTTTTGTACATACATATTTT

>66774_66774_3_PNPLA6-EXOSC10_PNPLA6_chr19_7606953_ENST00000414982_EXOSC10_chr1_11137005_ENST00000304457_length(amino acids)=660AA_BP=426
MEAPLQTGMMGTSSHGLATNSSGAKVAERDGFQDVLAPGEGSAGRICGAQPVPFVPQVLGVMIGAGVAVVVTAVLILLVVRRLRVPKTPA
PDGPRYRFRKRDKVLFYGRKIMRKVSQSTSSLVDTSVSATSRPRMRKKLKMLNIAKKILRIQKETPTLQRKEPPPAVLEADLTEGDLANS
HLPSEVLYMLKNVRVLGHFEKPLFLELCRHMVFQRLGQGDYVFRPGQPDASIYVVQDGLLELCLPGPDGKECVVKEVVPGDSVNSLLSIL
DVITGHQHPQRTVSARAARDSTVLRLPVEAFSAVFTKYPESLVRVVQIIMVRLQRVTFLALHNYLGLTNELFSHEIQPLRLFPSPGLPTR
TSPVRGSKRMVSTSATDEPRETPGRPPDPTGAPLPGPTGDPVKPTSLETPSAPLLSRCVSMPGDISGSVPVQKQASLFPDEKEDNLLGTT
CLIATAVITLFNEPSAEDSKKGPLTVAQKKAQNIMESFENPFRMISNRWKLAQVQVQKDSKEAVKKKAAEQTAAREQAKEACKAAAEQAI
SVRQQVVLENAAKKRERATSDPRTTEQKQEKKRLKISKKPKDPEPPEKEFTPYDYSQSDFKAFAGNSKSKVSSQFDPNKQTPSGKKCIAA

--------------------------------------------------------------
>66774_66774_4_PNPLA6-EXOSC10_PNPLA6_chr19_7606953_ENST00000414982_EXOSC10_chr1_11137005_ENST00000376936_length(transcript)=2353nt_BP=1474nt
CAATGGCGCCACCATCGGTCCCGGAGTCCCAGTGATGCTCTGTGCCATAGAGCCCCCATAACTTCACTACTACGTGATAGTAAATCCCCG
GCAAAAACCAGCAGCGCCTTGCAAGCCCACGCCACCCCAAGCATCCCAGGACTCTTCTGAAACGACTCCGGGCTACCAGATCGGCCGTCC
AGCTGGAATCAACCGATGGAGGCTCCGCTGCAAACTGGAATGATGGGGACATCGAGTCACGGGCTGGCTACGAACTCCTCGGGGGCGAAG
GTGGCGGAGAGGGATGGGTTCCAGGACGTCCTGGCGCCCGGGGAAGGCTCGGCGGGACGGATTTGCGGTGCGCAGCCAGTGCCGTTCGTC
CCTCAGGTGCTTGGCGTGATGATCGGGGCCGGAGTGGCGGTGGTGGTCACGGCCGTGCTCATCCTCCTGGTGGTGCGGAGGCTGCGAGTG
CCAAAAACCCCAGCCCCGGATGGCCCCCGGTATCGGTTCCGGAAGAGGGACAAAGTGCTCTTCTATGGCCGGAAGATTATGCGGAAGGTG
TCACAATCCACCTCCTCCCTCGTGGATACCTCTGTCTCCGCCACCTCCCGGCCACGCATGAGGAAGAAACTGAAGATGCTCAACATTGCC
AAGAAGATCCTGCGCATCCAGAAAGAGACGCCCACGCTGCAGCGGAAGGAGCCCCCGCCCGCAGTGCTAGAAGCTGACCTGACCGAGGGC
GACCTGGCTAACTCCCATCTGCCCTCTGAAGTGCTTTATATGCTCAAGAACGTCCGGGTGCTGGGCCACTTCGAGAAGCCACTCTTCCTG
GAGCTCTGCCGCCACATGGTCTTCCAGCGGCTGGGCCAGGGTGACTACGTCTTCCGGCCGGGCCAGCCAGATGCCAGCATCTACGTGGTG
CAGGACGGGCTGCTGGAGCTCTGTCTGCCAGGGCCTGACGGGAAGGAGTGTGTGGTGAAGGAAGTGGTTCCTGGGGACAGCGTCAACAGC
CTTCTCAGCATCCTGGATGTCATCACCGGTCACCAGCATCCCCAGCGGACCGTGTCTGCCCGGGCGGCCCGGGACTCCACGGTGCTGCGC
CTGCCGGTGGAAGCATTCTCCGCGGTCTTCACCAAGTACCCGGAGAGCTTGGTGCGGGTCGTGCAGATCATCATGGTGCGGCTGCAGCGA
GTCACCTTCCTGGCACTGCACAACTACCTGGGTCTGACCAATGAGCTCTTCAGCCACGAGATCCAGCCCCTGCGTCTGTTCCCCAGCCCC
GGCCTCCCAACTCGCACCAGCCCTGTGCGGGGCTCCAAGAGAATGGTCAGCACCTCAGCTACAGACGAGCCCAGGGAGACCCCAGGGCGG
CCACCCGATCCCACCGGGGCCCCGCTGCCTGGACCTACAGGGGACCCTGTGAAGCCCACATCCCTGGAAACCCCCTCGGCCCCTCTGCTG
AGCCGCTGCGTCTCCATGCCAGGGGACATCTCAGGATCTGTGCCAGTTCAGAAGCAGGCGAGCCTCTTCCCTGATGAAAAAGAAGATAAC
TTGCTGGGTACCACATGCCTGATTGCCACAGCTGTCATCACGTTATTTAATGAACCTAGTGCTGAAGACAGTAAAAAGGGTCCATTGACA
GTTGCACAGAAAAAAGCCCAGAACATCATGGAGTCCTTTGAAAATCCATTTAGGATGTTTCTGCCCTCACTGGGACACCGTGCTCCCGTC
TCTCAGGCAGCGAAGTTCGATCCATCAACCAAAATCTATGAAATCAGCAACCGCTGGAAGCTGGCCCAGGTACAAGTACAAAAAGACTCT
AAAGAAGCTGTCAAGAAGAAGGCAGCTGAGCAAACAGCTGCCCGGGAACAGGCAAAGGAGGCGTGCAAAGCTGCAGCAGAACAGGCCATC
TCCGTCCGACAGCAGGTCGTGCTAGAAAATGCTGCAAAGAAGAGAGAGCGAGCAACAAGCGACCCAAGGACCACAGAACAGAAACAAGAG
AAGAAACGACTCAAAATTTCCAAGAAGCCAAAGGACCCAGAGCCACCAGAAAAAGAGTTTACGCCTTACGACTACAGCCAGTCAGACTTC
AAGGCTTTTGCTGGAAACAGCAAATCCAAAGTTTCTTCTCAGTTTGATCCAAATAAACAGACCCCGTCTGGCAAGAAATGCATTGCAGCC
AAAAAAATTAAACAGTCGGTGGGAAACAAAAGCATGTCCTTTCCAACTGGAAAGTCAGACAGAGGCTTCAGGTACAACTGGCCACAGAGA
TAGTCCTGGAAGACACGTGGCGCCTGTGGACCGGAAGCACCAAATGCTGGTGCTGCTTTTGTACATACATATTTTTAAACCATTAAAATT

>66774_66774_4_PNPLA6-EXOSC10_PNPLA6_chr19_7606953_ENST00000414982_EXOSC10_chr1_11137005_ENST00000376936_length(amino acids)=685AA_BP=426
MEAPLQTGMMGTSSHGLATNSSGAKVAERDGFQDVLAPGEGSAGRICGAQPVPFVPQVLGVMIGAGVAVVVTAVLILLVVRRLRVPKTPA
PDGPRYRFRKRDKVLFYGRKIMRKVSQSTSSLVDTSVSATSRPRMRKKLKMLNIAKKILRIQKETPTLQRKEPPPAVLEADLTEGDLANS
HLPSEVLYMLKNVRVLGHFEKPLFLELCRHMVFQRLGQGDYVFRPGQPDASIYVVQDGLLELCLPGPDGKECVVKEVVPGDSVNSLLSIL
DVITGHQHPQRTVSARAARDSTVLRLPVEAFSAVFTKYPESLVRVVQIIMVRLQRVTFLALHNYLGLTNELFSHEIQPLRLFPSPGLPTR
TSPVRGSKRMVSTSATDEPRETPGRPPDPTGAPLPGPTGDPVKPTSLETPSAPLLSRCVSMPGDISGSVPVQKQASLFPDEKEDNLLGTT
CLIATAVITLFNEPSAEDSKKGPLTVAQKKAQNIMESFENPFRMFLPSLGHRAPVSQAAKFDPSTKIYEISNRWKLAQVQVQKDSKEAVK
KKAAEQTAAREQAKEACKAAAEQAISVRQQVVLENAAKKRERATSDPRTTEQKQEKKRLKISKKPKDPEPPEKEFTPYDYSQSDFKAFAG

--------------------------------------------------------------
>66774_66774_5_PNPLA6-EXOSC10_PNPLA6_chr19_7606953_ENST00000450331_EXOSC10_chr1_11137005_ENST00000304457_length(transcript)=2210nt_BP=1406nt
CAATGGCGCCACCATCGGTCCCGGAGTCCCAGTGATGCTCTGTGCCATAGAGCCCCCATAACTTCACTACTACGTGATAGTAAATCCCCG
GCAAAAACCAGCAGCGCCTTGCAAGCCCACGCCACCCCAAGCATCCCAGGACTCTTCTGAAACAGGGCAGTGACCCGGGAGGAAGTCACC
AGGTGCAGAGGACCGTGCCCTGTGGGGACCTGCCTGCAGGCTGCTGACAGACTCCGGGCTACCAGATCGGCCGTCCAGCTGGAATCAACC
GATGGAGGCTCCGCTGCAAACTGGAATGGTGCTTGGCGTGATGATCGGGGCCGGAGTGGCGGTGGTGGTCACGGCCGTGCTCATCCTCCT
GGTGGTGCGGAGGCTGCGAGTGCCAAAAACCCCAGCCCCGGATGGCCCCCGGTATCGGTTCCGGAAGAGGGACAAAGTGCTCTTCTATGG
CCGGAAGATTATGCGGAAGGTGTCACAATCCACCTCCTCCCTCGTGGATACCTCTGTCTCCGCCACCTCCCGGCCACGCATGAGGAAGAA
ACTGAAGATGCTCAACATTGCCAAGAAGATCCTGCGCATCCAGAAAGAGACGCCCACGCTGCAGCGGAAGGAGCCCCCGCCCGCAGTGCT
AGAAGCTGACCTGACCGAGGGCGACCTGGCTAACTCCCATCTGCCCTCTGAAGTGCTTTATATGCTCAAGAACGTCCGGGTGCTGGGCCA
CTTCGAGAAGCCACTCTTCCTGGAGCTCTGCCGCCACATGGTCTTCCAGCGGCTGGGCCAGGGTGACTACGTCTTCCGGCCGGGCCAGCC
AGATGCCAGCATCTACGTGGTGCAGGACGGGCTGCTGGAGCTCTGTCTGCCAGGGCCTGACGGGAAGGAGTGTGTGGTGAAGGAAGTGGT
TCCTGGGGACAGCGTCAACAGCCTTCTCAGCATCCTGGATGTCATCACCGGTCACCAGCATCCCCAGCGGACCGTGTCTGCCCGGGCGGC
CCGGGACTCCACGGTGCTGCGCCTGCCGGTGGAAGCATTCTCCGCGGTCTTCACCAAGTACCCGGAGAGCTTGGTGCGGGTCGTGCAGAT
CATCATGGTGCGGCTGCAGCGAGTCACCTTCCTGGCACTGCACAACTACCTGGGTCTGACCAATGAGCTCTTCAGCCACGAGATCCAGCC
CCTGCGTCTGTTCCCCAGCCCCGGCCTCCCAACTCGCACCAGCCCTGTGCGGGGCTCCAAGAGAATGGTCAGCACCTCAGCTACAGACGA
GCCCAGGGAGACCCCAGGGCGGCCACCCGATCCCACCGGGGCCCCGCTGCCTGGACCTACAGGGGACCCTGTGAAGCCCACATCCCTGGA
AACCCCCTCGGCCCCTCTGCTGAGCCGCTGCGTCTCCATGCCAGGGGACATCTCAGGATCTGTGCCAGTTCAGAAGCAGGCGAGCCTCTT
CCCTGATGAAAAAGAAGATAACTTGCTGGGTACCACATGCCTGATTGCCACAGCTGTCATCACGTTATTTAATGAACCTAGTGCTGAAGA
CAGTAAAAAGGGTCCATTGACAGTTGCACAGAAAAAAGCCCAGAACATCATGGAGTCCTTTGAAAATCCATTTAGGATGATCAGCAACCG
CTGGAAGCTGGCCCAGGTACAAGTACAAAAAGACTCTAAAGAAGCTGTCAAGAAGAAGGCAGCTGAGCAAACAGCTGCCCGGGAACAGGC
AAAGGAGGCGTGCAAAGCTGCAGCAGAACAGGCCATCTCCGTCCGACAGCAGGTCGTGCTAGAAAATGCTGCAAAGAAGAGAGAGCGAGC
AACAAGCGACCCAAGGACCACAGAACAGAAACAAGAGAAGAAACGACTCAAAATTTCCAAGAAGCCAAAGGACCCAGAGCCACCAGAAAA
AGAGTTTACGCCTTACGACTACAGCCAGTCAGACTTCAAGGCTTTTGCTGGAAACAGCAAATCCAAAGTTTCTTCTCAGTTTGATCCAAA
TAAACAGACCCCGTCTGGCAAGAAATGCATTGCAGCCAAAAAAATTAAACAGTCGGTGGGAAACAAAAGCATGTCCTTTCCAACTGGAAA
GTCAGACAGAGGCTTCAGGTACAACTGGCCACAGAGATAGTCCTGGAAGACACGTGGCGCCTGTGGACCGGAAGCACCAAATGCTGGTGC

>66774_66774_5_PNPLA6-EXOSC10_PNPLA6_chr19_7606953_ENST00000450331_EXOSC10_chr1_11137005_ENST00000304457_length(amino acids)=636AA_BP=402
MWGPACRLLTDSGLPDRPSSWNQPMEAPLQTGMVLGVMIGAGVAVVVTAVLILLVVRRLRVPKTPAPDGPRYRFRKRDKVLFYGRKIMRK
VSQSTSSLVDTSVSATSRPRMRKKLKMLNIAKKILRIQKETPTLQRKEPPPAVLEADLTEGDLANSHLPSEVLYMLKNVRVLGHFEKPLF
LELCRHMVFQRLGQGDYVFRPGQPDASIYVVQDGLLELCLPGPDGKECVVKEVVPGDSVNSLLSILDVITGHQHPQRTVSARAARDSTVL
RLPVEAFSAVFTKYPESLVRVVQIIMVRLQRVTFLALHNYLGLTNELFSHEIQPLRLFPSPGLPTRTSPVRGSKRMVSTSATDEPRETPG
RPPDPTGAPLPGPTGDPVKPTSLETPSAPLLSRCVSMPGDISGSVPVQKQASLFPDEKEDNLLGTTCLIATAVITLFNEPSAEDSKKGPL
TVAQKKAQNIMESFENPFRMISNRWKLAQVQVQKDSKEAVKKKAAEQTAAREQAKEACKAAAEQAISVRQQVVLENAAKKRERATSDPRT
TEQKQEKKRLKISKKPKDPEPPEKEFTPYDYSQSDFKAFAGNSKSKVSSQFDPNKQTPSGKKCIAAKKIKQSVGNKSMSFPTGKSDRGFR

--------------------------------------------------------------
>66774_66774_6_PNPLA6-EXOSC10_PNPLA6_chr19_7606953_ENST00000450331_EXOSC10_chr1_11137005_ENST00000376936_length(transcript)=2285nt_BP=1406nt
CAATGGCGCCACCATCGGTCCCGGAGTCCCAGTGATGCTCTGTGCCATAGAGCCCCCATAACTTCACTACTACGTGATAGTAAATCCCCG
GCAAAAACCAGCAGCGCCTTGCAAGCCCACGCCACCCCAAGCATCCCAGGACTCTTCTGAAACAGGGCAGTGACCCGGGAGGAAGTCACC
AGGTGCAGAGGACCGTGCCCTGTGGGGACCTGCCTGCAGGCTGCTGACAGACTCCGGGCTACCAGATCGGCCGTCCAGCTGGAATCAACC
GATGGAGGCTCCGCTGCAAACTGGAATGGTGCTTGGCGTGATGATCGGGGCCGGAGTGGCGGTGGTGGTCACGGCCGTGCTCATCCTCCT
GGTGGTGCGGAGGCTGCGAGTGCCAAAAACCCCAGCCCCGGATGGCCCCCGGTATCGGTTCCGGAAGAGGGACAAAGTGCTCTTCTATGG
CCGGAAGATTATGCGGAAGGTGTCACAATCCACCTCCTCCCTCGTGGATACCTCTGTCTCCGCCACCTCCCGGCCACGCATGAGGAAGAA
ACTGAAGATGCTCAACATTGCCAAGAAGATCCTGCGCATCCAGAAAGAGACGCCCACGCTGCAGCGGAAGGAGCCCCCGCCCGCAGTGCT
AGAAGCTGACCTGACCGAGGGCGACCTGGCTAACTCCCATCTGCCCTCTGAAGTGCTTTATATGCTCAAGAACGTCCGGGTGCTGGGCCA
CTTCGAGAAGCCACTCTTCCTGGAGCTCTGCCGCCACATGGTCTTCCAGCGGCTGGGCCAGGGTGACTACGTCTTCCGGCCGGGCCAGCC
AGATGCCAGCATCTACGTGGTGCAGGACGGGCTGCTGGAGCTCTGTCTGCCAGGGCCTGACGGGAAGGAGTGTGTGGTGAAGGAAGTGGT
TCCTGGGGACAGCGTCAACAGCCTTCTCAGCATCCTGGATGTCATCACCGGTCACCAGCATCCCCAGCGGACCGTGTCTGCCCGGGCGGC
CCGGGACTCCACGGTGCTGCGCCTGCCGGTGGAAGCATTCTCCGCGGTCTTCACCAAGTACCCGGAGAGCTTGGTGCGGGTCGTGCAGAT
CATCATGGTGCGGCTGCAGCGAGTCACCTTCCTGGCACTGCACAACTACCTGGGTCTGACCAATGAGCTCTTCAGCCACGAGATCCAGCC
CCTGCGTCTGTTCCCCAGCCCCGGCCTCCCAACTCGCACCAGCCCTGTGCGGGGCTCCAAGAGAATGGTCAGCACCTCAGCTACAGACGA
GCCCAGGGAGACCCCAGGGCGGCCACCCGATCCCACCGGGGCCCCGCTGCCTGGACCTACAGGGGACCCTGTGAAGCCCACATCCCTGGA
AACCCCCTCGGCCCCTCTGCTGAGCCGCTGCGTCTCCATGCCAGGGGACATCTCAGGATCTGTGCCAGTTCAGAAGCAGGCGAGCCTCTT
CCCTGATGAAAAAGAAGATAACTTGCTGGGTACCACATGCCTGATTGCCACAGCTGTCATCACGTTATTTAATGAACCTAGTGCTGAAGA
CAGTAAAAAGGGTCCATTGACAGTTGCACAGAAAAAAGCCCAGAACATCATGGAGTCCTTTGAAAATCCATTTAGGATGTTTCTGCCCTC
ACTGGGACACCGTGCTCCCGTCTCTCAGGCAGCGAAGTTCGATCCATCAACCAAAATCTATGAAATCAGCAACCGCTGGAAGCTGGCCCA
GGTACAAGTACAAAAAGACTCTAAAGAAGCTGTCAAGAAGAAGGCAGCTGAGCAAACAGCTGCCCGGGAACAGGCAAAGGAGGCGTGCAA
AGCTGCAGCAGAACAGGCCATCTCCGTCCGACAGCAGGTCGTGCTAGAAAATGCTGCAAAGAAGAGAGAGCGAGCAACAAGCGACCCAAG
GACCACAGAACAGAAACAAGAGAAGAAACGACTCAAAATTTCCAAGAAGCCAAAGGACCCAGAGCCACCAGAAAAAGAGTTTACGCCTTA
CGACTACAGCCAGTCAGACTTCAAGGCTTTTGCTGGAAACAGCAAATCCAAAGTTTCTTCTCAGTTTGATCCAAATAAACAGACCCCGTC
TGGCAAGAAATGCATTGCAGCCAAAAAAATTAAACAGTCGGTGGGAAACAAAAGCATGTCCTTTCCAACTGGAAAGTCAGACAGAGGCTT
CAGGTACAACTGGCCACAGAGATAGTCCTGGAAGACACGTGGCGCCTGTGGACCGGAAGCACCAAATGCTGGTGCTGCTTTTGTACATAC

>66774_66774_6_PNPLA6-EXOSC10_PNPLA6_chr19_7606953_ENST00000450331_EXOSC10_chr1_11137005_ENST00000376936_length(amino acids)=661AA_BP=402
MWGPACRLLTDSGLPDRPSSWNQPMEAPLQTGMVLGVMIGAGVAVVVTAVLILLVVRRLRVPKTPAPDGPRYRFRKRDKVLFYGRKIMRK
VSQSTSSLVDTSVSATSRPRMRKKLKMLNIAKKILRIQKETPTLQRKEPPPAVLEADLTEGDLANSHLPSEVLYMLKNVRVLGHFEKPLF
LELCRHMVFQRLGQGDYVFRPGQPDASIYVVQDGLLELCLPGPDGKECVVKEVVPGDSVNSLLSILDVITGHQHPQRTVSARAARDSTVL
RLPVEAFSAVFTKYPESLVRVVQIIMVRLQRVTFLALHNYLGLTNELFSHEIQPLRLFPSPGLPTRTSPVRGSKRMVSTSATDEPRETPG
RPPDPTGAPLPGPTGDPVKPTSLETPSAPLLSRCVSMPGDISGSVPVQKQASLFPDEKEDNLLGTTCLIATAVITLFNEPSAEDSKKGPL
TVAQKKAQNIMESFENPFRMFLPSLGHRAPVSQAAKFDPSTKIYEISNRWKLAQVQVQKDSKEAVKKKAAEQTAAREQAKEACKAAAEQA
ISVRQQVVLENAAKKRERATSDPRTTEQKQEKKRLKISKKPKDPEPPEKEFTPYDYSQSDFKAFAGNSKSKVSSQFDPNKQTPSGKKCIA

--------------------------------------------------------------
>66774_66774_7_PNPLA6-EXOSC10_PNPLA6_chr19_7606953_ENST00000545201_EXOSC10_chr1_11137005_ENST00000304457_length(transcript)=2339nt_BP=1535nt
GAGTCTGGGTTTCCGTTAGCCTCGCAGGGGTGTCCCTTCGAGGGTCGTTAGCGAGCCTCCGCTTTCCCACGATCTGTCCTCCGATTCCTG
TTAACTCTAGACTTTCTGATGTTCCCATACCCCCCACGTCTCGGCAGGTGTTTCCACACCGGTAGCCAGCTGTGCCCTGAGGTGGAAGAG
GACCGGCCACCCAGGAATTTTCCAACAATGGCGCCACCATCGGTCCCGGAGTCCCAGTGATGCTCTGTGCCATAGAGCCCCCATAACTTC
ACTACTACGTGATAGTAAATCCCCGGCAAAAACCAGCAGCGCCTTGCAAGCCCACGCCACCCCAAGCATCCCAGGACTCTTCTGAAACGA
CTCCGGGCTACCAGATCGGCCGTCCAGCTGGAATCAACCGATGGAGGCTCCGCTGCAAACTGGAATGGTGCTTGGCGTGATGATCGGGGC
CGGAGTGGCGGTGGTGGTCACGGCCGTGCTCATCCTCCTGGTGGTGCGGAGGCTGCGAGTGCCAAAAACCCCAGCCCCGGATGGCCCCCG
GTATCGGTTCCGGAAGAGGGACAAAGTGCTCTTCTATGGCCGGAAGATTATGCGGAAGGTGTCACAATCCACCTCCTCCCTCGTGGATAC
CTCTGTCTCCGCCACCTCCCGGCCACGCATGAGGAAGAAACTGAAGATGCTCAACATTGCCAAGAAGATCCTGCGCATCCAGAAAGAGAC
GCCCACGCTGCAGCGGAAGGAGCCCCCGCCCGCAGTGCTAGAAGCTGACCTGACCGAGGGCGACCTGGCTAACTCCCATCTGCCCTCTGA
AGTGCTTTATATGCTCAAGAACGTCCGGGTGCTGGGCCACTTCGAGAAGCCACTCTTCCTGGAGCTCTGCCGCCACATGGTCTTCCAGCG
GCTGGGCCAGGGTGACTACGTCTTCCGGCCGGGCCAGCCAGATGCCAGCATCTACGTGGTGCAGGACGGGCTGCTGGAGCTCTGTCTGCC
AGGGCCTGACGGGAAGGAGTGTGTGGTGAAGGAAGTGGTTCCTGGGGACAGCGTCAACAGCCTTCTCAGCATCCTGGATGTCATCACCGG
TCACCAGCATCCCCAGCGGACCGTGTCTGCCCGGGCGGCCCGGGACTCCACGGTGCTGCGCCTGCCGGTGGAAGCATTCTCCGCGGTCTT
CACCAAGTACCCGGAGAGCTTGGTGCGGGTCGTGCAGATCATCATGGTGCGGCTGCAGCGAGTCACCTTCCTGGCACTGCACAACTACCT
GGGTCTGACCAATGAGCTCTTCAGCCACGAGATCCAGCCCCTGCGTCTGTTCCCCAGCCCCGGCCTCCCAACTCGCACCAGCCCTGTGCG
GGGCTCCAAGAGAATGGTCAGCACCTCAGCTACAGACGAGCCCAGGGAGACCCCAGGGCGGCCACCCGATCCCACCGGGGCCCCGCTGCC
TGGACCTACAGGGGACCCTGTGAAGCCCACATCCCTGGAAACCCCCTCGGCCCCTCTGCTGAGCCGCTGCGTCTCCATGCCAGGGGACAT
CTCAGGATCTGTGCCAGTTCAGAAGCAGGCGAGCCTCTTCCCTGATGAAAAAGAAGATAACTTGCTGGGTACCACATGCCTGATTGCCAC
AGCTGTCATCACGTTATTTAATGAACCTAGTGCTGAAGACAGTAAAAAGGGTCCATTGACAGTTGCACAGAAAAAAGCCCAGAACATCAT
GGAGTCCTTTGAAAATCCATTTAGGATGATCAGCAACCGCTGGAAGCTGGCCCAGGTACAAGTACAAAAAGACTCTAAAGAAGCTGTCAA
GAAGAAGGCAGCTGAGCAAACAGCTGCCCGGGAACAGGCAAAGGAGGCGTGCAAAGCTGCAGCAGAACAGGCCATCTCCGTCCGACAGCA
GGTCGTGCTAGAAAATGCTGCAAAGAAGAGAGAGCGAGCAACAAGCGACCCAAGGACCACAGAACAGAAACAAGAGAAGAAACGACTCAA
AATTTCCAAGAAGCCAAAGGACCCAGAGCCACCAGAAAAAGAGTTTACGCCTTACGACTACAGCCAGTCAGACTTCAAGGCTTTTGCTGG
AAACAGCAAATCCAAAGTTTCTTCTCAGTTTGATCCAAATAAACAGACCCCGTCTGGCAAGAAATGCATTGCAGCCAAAAAAATTAAACA
GTCGGTGGGAAACAAAAGCATGTCCTTTCCAACTGGAAAGTCAGACAGAGGCTTCAGGTACAACTGGCCACAGAGATAGTCCTGGAAGAC

>66774_66774_7_PNPLA6-EXOSC10_PNPLA6_chr19_7606953_ENST00000545201_EXOSC10_chr1_11137005_ENST00000304457_length(amino acids)=612AA_BP=378
MEAPLQTGMVLGVMIGAGVAVVVTAVLILLVVRRLRVPKTPAPDGPRYRFRKRDKVLFYGRKIMRKVSQSTSSLVDTSVSATSRPRMRKK
LKMLNIAKKILRIQKETPTLQRKEPPPAVLEADLTEGDLANSHLPSEVLYMLKNVRVLGHFEKPLFLELCRHMVFQRLGQGDYVFRPGQP
DASIYVVQDGLLELCLPGPDGKECVVKEVVPGDSVNSLLSILDVITGHQHPQRTVSARAARDSTVLRLPVEAFSAVFTKYPESLVRVVQI
IMVRLQRVTFLALHNYLGLTNELFSHEIQPLRLFPSPGLPTRTSPVRGSKRMVSTSATDEPRETPGRPPDPTGAPLPGPTGDPVKPTSLE
TPSAPLLSRCVSMPGDISGSVPVQKQASLFPDEKEDNLLGTTCLIATAVITLFNEPSAEDSKKGPLTVAQKKAQNIMESFENPFRMISNR
WKLAQVQVQKDSKEAVKKKAAEQTAAREQAKEACKAAAEQAISVRQQVVLENAAKKRERATSDPRTTEQKQEKKRLKISKKPKDPEPPEK

--------------------------------------------------------------
>66774_66774_8_PNPLA6-EXOSC10_PNPLA6_chr19_7606953_ENST00000545201_EXOSC10_chr1_11137005_ENST00000376936_length(transcript)=2414nt_BP=1535nt
GAGTCTGGGTTTCCGTTAGCCTCGCAGGGGTGTCCCTTCGAGGGTCGTTAGCGAGCCTCCGCTTTCCCACGATCTGTCCTCCGATTCCTG
TTAACTCTAGACTTTCTGATGTTCCCATACCCCCCACGTCTCGGCAGGTGTTTCCACACCGGTAGCCAGCTGTGCCCTGAGGTGGAAGAG
GACCGGCCACCCAGGAATTTTCCAACAATGGCGCCACCATCGGTCCCGGAGTCCCAGTGATGCTCTGTGCCATAGAGCCCCCATAACTTC
ACTACTACGTGATAGTAAATCCCCGGCAAAAACCAGCAGCGCCTTGCAAGCCCACGCCACCCCAAGCATCCCAGGACTCTTCTGAAACGA
CTCCGGGCTACCAGATCGGCCGTCCAGCTGGAATCAACCGATGGAGGCTCCGCTGCAAACTGGAATGGTGCTTGGCGTGATGATCGGGGC
CGGAGTGGCGGTGGTGGTCACGGCCGTGCTCATCCTCCTGGTGGTGCGGAGGCTGCGAGTGCCAAAAACCCCAGCCCCGGATGGCCCCCG
GTATCGGTTCCGGAAGAGGGACAAAGTGCTCTTCTATGGCCGGAAGATTATGCGGAAGGTGTCACAATCCACCTCCTCCCTCGTGGATAC
CTCTGTCTCCGCCACCTCCCGGCCACGCATGAGGAAGAAACTGAAGATGCTCAACATTGCCAAGAAGATCCTGCGCATCCAGAAAGAGAC
GCCCACGCTGCAGCGGAAGGAGCCCCCGCCCGCAGTGCTAGAAGCTGACCTGACCGAGGGCGACCTGGCTAACTCCCATCTGCCCTCTGA
AGTGCTTTATATGCTCAAGAACGTCCGGGTGCTGGGCCACTTCGAGAAGCCACTCTTCCTGGAGCTCTGCCGCCACATGGTCTTCCAGCG
GCTGGGCCAGGGTGACTACGTCTTCCGGCCGGGCCAGCCAGATGCCAGCATCTACGTGGTGCAGGACGGGCTGCTGGAGCTCTGTCTGCC
AGGGCCTGACGGGAAGGAGTGTGTGGTGAAGGAAGTGGTTCCTGGGGACAGCGTCAACAGCCTTCTCAGCATCCTGGATGTCATCACCGG
TCACCAGCATCCCCAGCGGACCGTGTCTGCCCGGGCGGCCCGGGACTCCACGGTGCTGCGCCTGCCGGTGGAAGCATTCTCCGCGGTCTT
CACCAAGTACCCGGAGAGCTTGGTGCGGGTCGTGCAGATCATCATGGTGCGGCTGCAGCGAGTCACCTTCCTGGCACTGCACAACTACCT
GGGTCTGACCAATGAGCTCTTCAGCCACGAGATCCAGCCCCTGCGTCTGTTCCCCAGCCCCGGCCTCCCAACTCGCACCAGCCCTGTGCG
GGGCTCCAAGAGAATGGTCAGCACCTCAGCTACAGACGAGCCCAGGGAGACCCCAGGGCGGCCACCCGATCCCACCGGGGCCCCGCTGCC
TGGACCTACAGGGGACCCTGTGAAGCCCACATCCCTGGAAACCCCCTCGGCCCCTCTGCTGAGCCGCTGCGTCTCCATGCCAGGGGACAT
CTCAGGATCTGTGCCAGTTCAGAAGCAGGCGAGCCTCTTCCCTGATGAAAAAGAAGATAACTTGCTGGGTACCACATGCCTGATTGCCAC
AGCTGTCATCACGTTATTTAATGAACCTAGTGCTGAAGACAGTAAAAAGGGTCCATTGACAGTTGCACAGAAAAAAGCCCAGAACATCAT
GGAGTCCTTTGAAAATCCATTTAGGATGTTTCTGCCCTCACTGGGACACCGTGCTCCCGTCTCTCAGGCAGCGAAGTTCGATCCATCAAC
CAAAATCTATGAAATCAGCAACCGCTGGAAGCTGGCCCAGGTACAAGTACAAAAAGACTCTAAAGAAGCTGTCAAGAAGAAGGCAGCTGA
GCAAACAGCTGCCCGGGAACAGGCAAAGGAGGCGTGCAAAGCTGCAGCAGAACAGGCCATCTCCGTCCGACAGCAGGTCGTGCTAGAAAA
TGCTGCAAAGAAGAGAGAGCGAGCAACAAGCGACCCAAGGACCACAGAACAGAAACAAGAGAAGAAACGACTCAAAATTTCCAAGAAGCC
AAAGGACCCAGAGCCACCAGAAAAAGAGTTTACGCCTTACGACTACAGCCAGTCAGACTTCAAGGCTTTTGCTGGAAACAGCAAATCCAA
AGTTTCTTCTCAGTTTGATCCAAATAAACAGACCCCGTCTGGCAAGAAATGCATTGCAGCCAAAAAAATTAAACAGTCGGTGGGAAACAA
AAGCATGTCCTTTCCAACTGGAAAGTCAGACAGAGGCTTCAGGTACAACTGGCCACAGAGATAGTCCTGGAAGACACGTGGCGCCTGTGG

>66774_66774_8_PNPLA6-EXOSC10_PNPLA6_chr19_7606953_ENST00000545201_EXOSC10_chr1_11137005_ENST00000376936_length(amino acids)=637AA_BP=378
MEAPLQTGMVLGVMIGAGVAVVVTAVLILLVVRRLRVPKTPAPDGPRYRFRKRDKVLFYGRKIMRKVSQSTSSLVDTSVSATSRPRMRKK
LKMLNIAKKILRIQKETPTLQRKEPPPAVLEADLTEGDLANSHLPSEVLYMLKNVRVLGHFEKPLFLELCRHMVFQRLGQGDYVFRPGQP
DASIYVVQDGLLELCLPGPDGKECVVKEVVPGDSVNSLLSILDVITGHQHPQRTVSARAARDSTVLRLPVEAFSAVFTKYPESLVRVVQI
IMVRLQRVTFLALHNYLGLTNELFSHEIQPLRLFPSPGLPTRTSPVRGSKRMVSTSATDEPRETPGRPPDPTGAPLPGPTGDPVKPTSLE
TPSAPLLSRCVSMPGDISGSVPVQKQASLFPDEKEDNLLGTTCLIATAVITLFNEPSAEDSKKGPLTVAQKKAQNIMESFENPFRMFLPS
LGHRAPVSQAAKFDPSTKIYEISNRWKLAQVQVQKDSKEAVKKKAAEQTAAREQAKEACKAAAEQAISVRQQVVLENAAKKRERATSDPR
TTEQKQEKKRLKISKKPKDPEPPEKEFTPYDYSQSDFKAFAGNSKSKVSSQFDPNKQTPSGKKCIAAKKIKQSVGNKSMSFPTGKSDRGF

--------------------------------------------------------------
>66774_66774_9_PNPLA6-EXOSC10_PNPLA6_chr19_7606953_ENST00000600737_EXOSC10_chr1_11137005_ENST00000304457_length(transcript)=2139nt_BP=1335nt
TTTCCCGGCATGCACTGCGGGCCGCCGGGCCTCAGGGAAGAGTCGCGCCCCCGGGGAGGGAGCAGCACTGGCCCATTCTGCAGATGGGGA
CATCGAGTCACGGGCTGGCTACGAACTCCTCGGGGGCGAAGGTGGCGGAGAGGGATGGGTTCCAGGACGTCCTGGCGCCCGGGGAAGGCT
CGGCGGGACGGATTTGCGGTGCGCAGCCAGTGCCGTTCGTCCCTCAGGTGCTTGGCGTGATGATCGGGGCCGGAGTGGCGGTGGTGGTCA
CGGCCGTGCTCATCCTCCTGGTGGTGCGGAGGCTGCGAGTGCCAAAAACCCCAGCCCCGGATGGCCCCCGGTATCGGTTCCGGAAGAGGG
ACAAAGTGCTCTTCTATGGCCGGAAGATTATGCGGAAGGTGTCACAATCCACCTCCTCCCTCGTGGATACCTCTGTCTCCGCCACCTCCC
GGCCACGCATGAGGAAGAAACTGAAGATGCTCAACATTGCCAAGAAGATCCTGCGCATCCAGAAAGAGACGCCCACGCTGCAGCGGAAGG
AGCCCCCGCCCGCAGTGCTAGAAGCTGACCTGACCGAGGGCGACCTGGCTAACTCCCATCTGCCCTCTGAAGTGCTTTATATGCTCAAGA
ACGTCCGGGTGCTGGGCCACTTCGAGAAGCCACTCTTCCTGGAGCTCTGCCGCCACATGGTCTTCCAGCGGCTGGGCCAGGGTGACTACG
TCTTCCGGCCGGGCCAGCCAGATGCCAGCATCTACGTGGTGCAGGACGGGCTGCTGGAGCTCTGTCTGCCAGGGCCTGACGGGAAGGAGT
GTGTGGTGAAGGAAGTGGTTCCTGGGGACAGCGTCAACAGCCTTCTCAGCATCCTGGATGTCATCACCGGTCACCAGCATCCCCAGCGGA
CCGTGTCTGCCCGGGCGGCCCGGGACTCCACGGTGCTGCGCCTGCCGGTGGAAGCATTCTCCGCGGTCTTCACCAAGTACCCGGAGAGCT
TGGTGCGGGTCGTGCAGATCATCATGGTGCGGCTGCAGCGAGTCACCTTCCTGGCACTGCACAACTACCTGGGTCTGACCAATGAGCTCT
TCAGCCACGAGATCCAGCCCCTGCGTCTGTTCCCCAGCCCCGGCCTCCCAACTCGCACCAGCCCTGTGCGGGGCTCCAAGAGAATGGTCA
GCACCTCAGCTACAGACGAGCCCAGGGAGACCCCAGGGCGGCCACCCGATCCCACCGGGGCCCCGCTGCCTGGACCTACAGGGGACCCTG
TGAAGCCCACATCCCTGGAAACCCCCTCGGCCCCTCTGCTGAGCCGCTGCGTCTCCATGCCAGGGGACATCTCAGGATCTGTGCCAGTTC
AGAAGCAGGCGAGCCTCTTCCCTGATGAAAAAGAAGATAACTTGCTGGGTACCACATGCCTGATTGCCACAGCTGTCATCACGTTATTTA
ATGAACCTAGTGCTGAAGACAGTAAAAAGGGTCCATTGACAGTTGCACAGAAAAAAGCCCAGAACATCATGGAGTCCTTTGAAAATCCAT
TTAGGATGATCAGCAACCGCTGGAAGCTGGCCCAGGTACAAGTACAAAAAGACTCTAAAGAAGCTGTCAAGAAGAAGGCAGCTGAGCAAA
CAGCTGCCCGGGAACAGGCAAAGGAGGCGTGCAAAGCTGCAGCAGAACAGGCCATCTCCGTCCGACAGCAGGTCGTGCTAGAAAATGCTG
CAAAGAAGAGAGAGCGAGCAACAAGCGACCCAAGGACCACAGAACAGAAACAAGAGAAGAAACGACTCAAAATTTCCAAGAAGCCAAAGG
ACCCAGAGCCACCAGAAAAAGAGTTTACGCCTTACGACTACAGCCAGTCAGACTTCAAGGCTTTTGCTGGAAACAGCAAATCCAAAGTTT
CTTCTCAGTTTGATCCAAATAAACAGACCCCGTCTGGCAAGAAATGCATTGCAGCCAAAAAAATTAAACAGTCGGTGGGAAACAAAAGCA
TGTCCTTTCCAACTGGAAAGTCAGACAGAGGCTTCAGGTACAACTGGCCACAGAGATAGTCCTGGAAGACACGTGGCGCCTGTGGACCGG

>66774_66774_9_PNPLA6-EXOSC10_PNPLA6_chr19_7606953_ENST00000600737_EXOSC10_chr1_11137005_ENST00000304457_length(amino acids)=674AA_BP=440
MRAAGPQGRVAPPGREQHWPILQMGTSSHGLATNSSGAKVAERDGFQDVLAPGEGSAGRICGAQPVPFVPQVLGVMIGAGVAVVVTAVLI
LLVVRRLRVPKTPAPDGPRYRFRKRDKVLFYGRKIMRKVSQSTSSLVDTSVSATSRPRMRKKLKMLNIAKKILRIQKETPTLQRKEPPPA
VLEADLTEGDLANSHLPSEVLYMLKNVRVLGHFEKPLFLELCRHMVFQRLGQGDYVFRPGQPDASIYVVQDGLLELCLPGPDGKECVVKE
VVPGDSVNSLLSILDVITGHQHPQRTVSARAARDSTVLRLPVEAFSAVFTKYPESLVRVVQIIMVRLQRVTFLALHNYLGLTNELFSHEI
QPLRLFPSPGLPTRTSPVRGSKRMVSTSATDEPRETPGRPPDPTGAPLPGPTGDPVKPTSLETPSAPLLSRCVSMPGDISGSVPVQKQAS
LFPDEKEDNLLGTTCLIATAVITLFNEPSAEDSKKGPLTVAQKKAQNIMESFENPFRMISNRWKLAQVQVQKDSKEAVKKKAAEQTAARE
QAKEACKAAAEQAISVRQQVVLENAAKKRERATSDPRTTEQKQEKKRLKISKKPKDPEPPEKEFTPYDYSQSDFKAFAGNSKSKVSSQFD

--------------------------------------------------------------
>66774_66774_10_PNPLA6-EXOSC10_PNPLA6_chr19_7606953_ENST00000600737_EXOSC10_chr1_11137005_ENST00000376936_length(transcript)=2214nt_BP=1335nt
TTTCCCGGCATGCACTGCGGGCCGCCGGGCCTCAGGGAAGAGTCGCGCCCCCGGGGAGGGAGCAGCACTGGCCCATTCTGCAGATGGGGA
CATCGAGTCACGGGCTGGCTACGAACTCCTCGGGGGCGAAGGTGGCGGAGAGGGATGGGTTCCAGGACGTCCTGGCGCCCGGGGAAGGCT
CGGCGGGACGGATTTGCGGTGCGCAGCCAGTGCCGTTCGTCCCTCAGGTGCTTGGCGTGATGATCGGGGCCGGAGTGGCGGTGGTGGTCA
CGGCCGTGCTCATCCTCCTGGTGGTGCGGAGGCTGCGAGTGCCAAAAACCCCAGCCCCGGATGGCCCCCGGTATCGGTTCCGGAAGAGGG
ACAAAGTGCTCTTCTATGGCCGGAAGATTATGCGGAAGGTGTCACAATCCACCTCCTCCCTCGTGGATACCTCTGTCTCCGCCACCTCCC
GGCCACGCATGAGGAAGAAACTGAAGATGCTCAACATTGCCAAGAAGATCCTGCGCATCCAGAAAGAGACGCCCACGCTGCAGCGGAAGG
AGCCCCCGCCCGCAGTGCTAGAAGCTGACCTGACCGAGGGCGACCTGGCTAACTCCCATCTGCCCTCTGAAGTGCTTTATATGCTCAAGA
ACGTCCGGGTGCTGGGCCACTTCGAGAAGCCACTCTTCCTGGAGCTCTGCCGCCACATGGTCTTCCAGCGGCTGGGCCAGGGTGACTACG
TCTTCCGGCCGGGCCAGCCAGATGCCAGCATCTACGTGGTGCAGGACGGGCTGCTGGAGCTCTGTCTGCCAGGGCCTGACGGGAAGGAGT
GTGTGGTGAAGGAAGTGGTTCCTGGGGACAGCGTCAACAGCCTTCTCAGCATCCTGGATGTCATCACCGGTCACCAGCATCCCCAGCGGA
CCGTGTCTGCCCGGGCGGCCCGGGACTCCACGGTGCTGCGCCTGCCGGTGGAAGCATTCTCCGCGGTCTTCACCAAGTACCCGGAGAGCT
TGGTGCGGGTCGTGCAGATCATCATGGTGCGGCTGCAGCGAGTCACCTTCCTGGCACTGCACAACTACCTGGGTCTGACCAATGAGCTCT
TCAGCCACGAGATCCAGCCCCTGCGTCTGTTCCCCAGCCCCGGCCTCCCAACTCGCACCAGCCCTGTGCGGGGCTCCAAGAGAATGGTCA
GCACCTCAGCTACAGACGAGCCCAGGGAGACCCCAGGGCGGCCACCCGATCCCACCGGGGCCCCGCTGCCTGGACCTACAGGGGACCCTG
TGAAGCCCACATCCCTGGAAACCCCCTCGGCCCCTCTGCTGAGCCGCTGCGTCTCCATGCCAGGGGACATCTCAGGATCTGTGCCAGTTC
AGAAGCAGGCGAGCCTCTTCCCTGATGAAAAAGAAGATAACTTGCTGGGTACCACATGCCTGATTGCCACAGCTGTCATCACGTTATTTA
ATGAACCTAGTGCTGAAGACAGTAAAAAGGGTCCATTGACAGTTGCACAGAAAAAAGCCCAGAACATCATGGAGTCCTTTGAAAATCCAT
TTAGGATGTTTCTGCCCTCACTGGGACACCGTGCTCCCGTCTCTCAGGCAGCGAAGTTCGATCCATCAACCAAAATCTATGAAATCAGCA
ACCGCTGGAAGCTGGCCCAGGTACAAGTACAAAAAGACTCTAAAGAAGCTGTCAAGAAGAAGGCAGCTGAGCAAACAGCTGCCCGGGAAC
AGGCAAAGGAGGCGTGCAAAGCTGCAGCAGAACAGGCCATCTCCGTCCGACAGCAGGTCGTGCTAGAAAATGCTGCAAAGAAGAGAGAGC
GAGCAACAAGCGACCCAAGGACCACAGAACAGAAACAAGAGAAGAAACGACTCAAAATTTCCAAGAAGCCAAAGGACCCAGAGCCACCAG
AAAAAGAGTTTACGCCTTACGACTACAGCCAGTCAGACTTCAAGGCTTTTGCTGGAAACAGCAAATCCAAAGTTTCTTCTCAGTTTGATC
CAAATAAACAGACCCCGTCTGGCAAGAAATGCATTGCAGCCAAAAAAATTAAACAGTCGGTGGGAAACAAAAGCATGTCCTTTCCAACTG
GAAAGTCAGACAGAGGCTTCAGGTACAACTGGCCACAGAGATAGTCCTGGAAGACACGTGGCGCCTGTGGACCGGAAGCACCAAATGCTG

>66774_66774_10_PNPLA6-EXOSC10_PNPLA6_chr19_7606953_ENST00000600737_EXOSC10_chr1_11137005_ENST00000376936_length(amino acids)=699AA_BP=440
MRAAGPQGRVAPPGREQHWPILQMGTSSHGLATNSSGAKVAERDGFQDVLAPGEGSAGRICGAQPVPFVPQVLGVMIGAGVAVVVTAVLI
LLVVRRLRVPKTPAPDGPRYRFRKRDKVLFYGRKIMRKVSQSTSSLVDTSVSATSRPRMRKKLKMLNIAKKILRIQKETPTLQRKEPPPA
VLEADLTEGDLANSHLPSEVLYMLKNVRVLGHFEKPLFLELCRHMVFQRLGQGDYVFRPGQPDASIYVVQDGLLELCLPGPDGKECVVKE
VVPGDSVNSLLSILDVITGHQHPQRTVSARAARDSTVLRLPVEAFSAVFTKYPESLVRVVQIIMVRLQRVTFLALHNYLGLTNELFSHEI
QPLRLFPSPGLPTRTSPVRGSKRMVSTSATDEPRETPGRPPDPTGAPLPGPTGDPVKPTSLETPSAPLLSRCVSMPGDISGSVPVQKQAS
LFPDEKEDNLLGTTCLIATAVITLFNEPSAEDSKKGPLTVAQKKAQNIMESFENPFRMFLPSLGHRAPVSQAAKFDPSTKIYEISNRWKL
AQVQVQKDSKEAVKKKAAEQTAAREQAKEACKAAAEQAISVRQQVVLENAAKKRERATSDPRTTEQKQEKKRLKISKKPKDPEPPEKEFT

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PNPLA6-EXOSC10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PNPLA6-EXOSC10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PNPLA6-EXOSC10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource