FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:ARMC8-CLDN18 (FusionGDB2 ID:6678)

Fusion Gene Summary for ARMC8-CLDN18

check button Fusion gene summary
Fusion gene informationFusion gene name: ARMC8-CLDN18
Fusion gene ID: 6678
HgeneTgene
Gene symbol

ARMC8

CLDN18

Gene ID

25852

51208

Gene namearmadillo repeat containing 8claudin 18
SynonymsGID5|HSPC056|S863-2|VID28SFTA5|SFTPJ
Cytomap

3q22.3

3q22.3

Type of geneprotein-codingprotein-coding
Descriptionarmadillo repeat-containing protein 8GID complex subunit 5, VID28 homologclaudin-18surfactant associated 5surfactant associated protein Jsurfactant, pulmonary associated protein J
Modification date2020031320200313
UniProtAcc

Q8IUR7

P56856

Ensembl transtripts involved in fusion geneENST00000358441, ENST00000471453, 
ENST00000481646, ENST00000485396, 
ENST00000489213, ENST00000491704, 
ENST00000393058, ENST00000461822, 
ENST00000469044, ENST00000470821, 
ENST00000538260, 		ENST00000183605, 
ENST00000343735, 
Fusion gene scores* DoF score11 X 11 X 5=6056 X 7 X 5=210
# samples 139
** MAII scorelog2(13/605*10)=-2.2184235191335
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/210*10)=-1.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARMC8 [Title/Abstract] AND CLDN18 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARMC8(137906441)-CLDN18(137742500), # samples:3
Anticipated loss of major functional domain due to fusion event.ARMC8-CLDN18 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ARMC8-CLDN18 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ARMC8 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CLDN18 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-E1-5303-01AARMC8chr3

137906441

-CLDN18chr3

137742500

+
ChimerDB4LGGTCGA-E1-5303-01AARMC8chr3

137906441

+CLDN18chr3

137742500

+
ChimerDB4LGGTCGA-E1-5303ARMC8chr3

137906441

+CLDN18chr3

137742500

+
ChimerDB4LGGTCGA-E1-5303ARMC8chr3

137928735

+CLDN18chr3

137742500

+
ChimerDB4STADTCGA-VQ-A8PX-01AARMC8chr3

137907372

+CLDN18chr3

137748639

+


Top

Fusion Gene ORF analysis for ARMC8-CLDN18

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000358441ENST00000183605ARMC8chr3

137906441

+CLDN18chr3

137742500

+
5UTR-3CDSENST00000358441ENST00000343735ARMC8chr3

137906441

+CLDN18chr3

137742500

+
5UTR-3CDSENST00000471453ENST00000183605ARMC8chr3

137906441

+CLDN18chr3

137742500

+
5UTR-3CDSENST00000471453ENST00000343735ARMC8chr3

137906441

+CLDN18chr3

137742500

+
5UTR-3CDSENST00000481646ENST00000183605ARMC8chr3

137906441

+CLDN18chr3

137742500

+
5UTR-3CDSENST00000481646ENST00000343735ARMC8chr3

137906441

+CLDN18chr3

137742500

+
5UTR-3CDSENST00000485396ENST00000183605ARMC8chr3

137906441

+CLDN18chr3

137742500

+
5UTR-3CDSENST00000485396ENST00000343735ARMC8chr3

137906441

+CLDN18chr3

137742500

+
5UTR-3CDSENST00000489213ENST00000183605ARMC8chr3

137906441

+CLDN18chr3

137742500

+
5UTR-3CDSENST00000489213ENST00000343735ARMC8chr3

137906441

+CLDN18chr3

137742500

+
5UTR-3CDSENST00000491704ENST00000183605ARMC8chr3

137906441

+CLDN18chr3

137742500

+
5UTR-3CDSENST00000491704ENST00000183605ARMC8chr3

137907372

+CLDN18chr3

137748639

+
5UTR-3CDSENST00000491704ENST00000343735ARMC8chr3

137906441

+CLDN18chr3

137742500

+
5UTR-3CDSENST00000491704ENST00000343735ARMC8chr3

137907372

+CLDN18chr3

137748639

+
Frame-shiftENST00000358441ENST00000183605ARMC8chr3

137928735

+CLDN18chr3

137742500

+
Frame-shiftENST00000358441ENST00000183605ARMC8chr3

137907372

+CLDN18chr3

137748639

+
Frame-shiftENST00000358441ENST00000343735ARMC8chr3

137928735

+CLDN18chr3

137742500

+
Frame-shiftENST00000358441ENST00000343735ARMC8chr3

137907372

+CLDN18chr3

137748639

+
Frame-shiftENST00000393058ENST00000183605ARMC8chr3

137906441

+CLDN18chr3

137742500

+
Frame-shiftENST00000393058ENST00000183605ARMC8chr3

137928735

+CLDN18chr3

137742500

+
Frame-shiftENST00000393058ENST00000343735ARMC8chr3

137906441

+CLDN18chr3

137742500

+
Frame-shiftENST00000393058ENST00000343735ARMC8chr3

137928735

+CLDN18chr3

137742500

+
Frame-shiftENST00000461822ENST00000183605ARMC8chr3

137906441

+CLDN18chr3

137742500

+
Frame-shiftENST00000461822ENST00000183605ARMC8chr3

137928735

+CLDN18chr3

137742500

+
Frame-shiftENST00000461822ENST00000343735ARMC8chr3

137906441

+CLDN18chr3

137742500

+
Frame-shiftENST00000461822ENST00000343735ARMC8chr3

137928735

+CLDN18chr3

137742500

+
Frame-shiftENST00000469044ENST00000183605ARMC8chr3

137906441

+CLDN18chr3

137742500

+
Frame-shiftENST00000469044ENST00000183605ARMC8chr3

137928735

+CLDN18chr3

137742500

+
Frame-shiftENST00000469044ENST00000343735ARMC8chr3

137906441

+CLDN18chr3

137742500

+
Frame-shiftENST00000469044ENST00000343735ARMC8chr3

137928735

+CLDN18chr3

137742500

+
Frame-shiftENST00000470821ENST00000183605ARMC8chr3

137906441

+CLDN18chr3

137742500

+
Frame-shiftENST00000470821ENST00000183605ARMC8chr3

137928735

+CLDN18chr3

137742500

+
Frame-shiftENST00000470821ENST00000343735ARMC8chr3

137906441

+CLDN18chr3

137742500

+
Frame-shiftENST00000470821ENST00000343735ARMC8chr3

137928735

+CLDN18chr3

137742500

+
Frame-shiftENST00000471453ENST00000183605ARMC8chr3

137928735

+CLDN18chr3

137742500

+
Frame-shiftENST00000471453ENST00000183605ARMC8chr3

137907372

+CLDN18chr3

137748639

+
Frame-shiftENST00000471453ENST00000343735ARMC8chr3

137928735

+CLDN18chr3

137742500

+
Frame-shiftENST00000471453ENST00000343735ARMC8chr3

137907372

+CLDN18chr3

137748639

+
Frame-shiftENST00000481646ENST00000183605ARMC8chr3

137928735

+CLDN18chr3

137742500

+
Frame-shiftENST00000481646ENST00000183605ARMC8chr3

137907372

+CLDN18chr3

137748639

+
Frame-shiftENST00000481646ENST00000343735ARMC8chr3

137928735

+CLDN18chr3

137742500

+
Frame-shiftENST00000481646ENST00000343735ARMC8chr3

137907372

+CLDN18chr3

137748639

+
Frame-shiftENST00000538260ENST00000183605ARMC8chr3

137906441

+CLDN18chr3

137742500

+
Frame-shiftENST00000538260ENST00000183605ARMC8chr3

137928735

+CLDN18chr3

137742500

+
Frame-shiftENST00000538260ENST00000343735ARMC8chr3

137906441

+CLDN18chr3

137742500

+
Frame-shiftENST00000538260ENST00000343735ARMC8chr3

137928735

+CLDN18chr3

137742500

+
intron-3CDSENST00000393058ENST00000183605ARMC8chr3

137907372

+CLDN18chr3

137748639

+
intron-3CDSENST00000393058ENST00000343735ARMC8chr3

137907372

+CLDN18chr3

137748639

+
intron-3CDSENST00000461822ENST00000183605ARMC8chr3

137907372

+CLDN18chr3

137748639

+
intron-3CDSENST00000461822ENST00000343735ARMC8chr3

137907372

+CLDN18chr3

137748639

+
intron-3CDSENST00000469044ENST00000183605ARMC8chr3

137907372

+CLDN18chr3

137748639

+
intron-3CDSENST00000469044ENST00000343735ARMC8chr3

137907372

+CLDN18chr3

137748639

+
intron-3CDSENST00000470821ENST00000183605ARMC8chr3

137907372

+CLDN18chr3

137748639

+
intron-3CDSENST00000470821ENST00000343735ARMC8chr3

137907372

+CLDN18chr3

137748639

+
intron-3CDSENST00000485396ENST00000183605ARMC8chr3

137928735

+CLDN18chr3

137742500

+
intron-3CDSENST00000485396ENST00000183605ARMC8chr3

137907372

+CLDN18chr3

137748639

+
intron-3CDSENST00000485396ENST00000343735ARMC8chr3

137928735

+CLDN18chr3

137742500

+
intron-3CDSENST00000485396ENST00000343735ARMC8chr3

137907372

+CLDN18chr3

137748639

+
intron-3CDSENST00000489213ENST00000183605ARMC8chr3

137928735

+CLDN18chr3

137742500

+
intron-3CDSENST00000489213ENST00000183605ARMC8chr3

137907372

+CLDN18chr3

137748639

+
intron-3CDSENST00000489213ENST00000343735ARMC8chr3

137928735

+CLDN18chr3

137742500

+
intron-3CDSENST00000489213ENST00000343735ARMC8chr3

137907372

+CLDN18chr3

137748639

+
intron-3CDSENST00000491704ENST00000183605ARMC8chr3

137928735

+CLDN18chr3

137742500

+
intron-3CDSENST00000491704ENST00000343735ARMC8chr3

137928735

+CLDN18chr3

137742500

+
intron-3CDSENST00000538260ENST00000183605ARMC8chr3

137907372

+CLDN18chr3

137748639

+
intron-3CDSENST00000538260ENST00000343735ARMC8chr3

137907372

+CLDN18chr3

137748639

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for ARMC8-CLDN18


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ARMC8chr3137907372+CLDN18chr3137748638+1.30E-060.9999987
ARMC8chr3137906441+CLDN18chr3137742499+1.16E-091
ARMC8chr3137906441+CLDN18chr3137742499+1.16E-091
ARMC8chr3137928735+CLDN18chr3137742499+1.19E-081
ARMC8chr3137907372+CLDN18chr3137748638+1.30E-060.9999987
ARMC8chr3137906441+CLDN18chr3137742499+1.16E-091
ARMC8chr3137906441+CLDN18chr3137742499+1.16E-091
ARMC8chr3137928735+CLDN18chr3137742499+1.19E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for ARMC8-CLDN18


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:137906441/:137742500)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARMC8

Q8IUR7

CLDN18

P56856

FUNCTION: Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. {ECO:0000269|PubMed:29911972}.FUNCTION: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for ARMC8-CLDN18


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for ARMC8-CLDN18


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for ARMC8-CLDN18


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for ARMC8-CLDN18


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource