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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PNPLA8-CFTR (FusionGDB2 ID:66785)

Fusion Gene Summary for PNPLA8-CFTR

check button Fusion gene summary
Fusion gene informationFusion gene name: PNPLA8-CFTR
Fusion gene ID: 66785
HgeneTgene
Gene symbol

PNPLA8

CFTR

Gene ID

50640

1080

Gene namepatatin like phospholipase domain containing 8CF transmembrane conductance regulator
SynonymsIPLA2-2|IPLA2G|MMLA|PNPLA-gamma|iPLA2gammaABC35|ABCC7|CF|CFTR/MRP|MRP7|TNR-CFTR|dJ760C5.1
Cytomap

7q31.1

7q31.2

Type of geneprotein-codingprotein-coding
Descriptioncalcium-independent phospholipase A2-gammaintracellular membrane-associated calcium-independent phospholipase A2 gammamembrane-associated calcium-independent phospholipase A2 gammacystic fibrosis transmembrane conductance regulatorcAMP-dependent chloride channelchannel conductance-controlling ATPasecystic fibrosis transmembrane conductance regulatingcystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-f
Modification date2020031320200329
UniProtAcc.

P13569

Ensembl transtripts involved in fusion geneENST00000257694, ENST00000422087, 
ENST00000436062, ENST00000453144, 
ENST00000388728, ENST00000426128, 
ENST00000483879, 		ENST00000608965, 
ENST00000003084, ENST00000454343, 
Fusion gene scores* DoF score2 X 2 X 2=813 X 15 X 10=1950
# samples 213
** MAII scorelog2(2/8*10)=1.32192809488736log2(13/1950*10)=-3.90689059560852
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PNPLA8 [Title/Abstract] AND CFTR [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPNPLA8(108128203)-CFTR(117282492), # samples:3
Anticipated loss of major functional domain due to fusion event.PNPLA8-CFTR seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
PNPLA8-CFTR seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PNPLA8-CFTR seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
PNPLA8-CFTR seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePNPLA8

GO:0001516

prostaglandin biosynthetic process

15695510

HgenePNPLA8

GO:0006631

fatty acid metabolic process

10744668

HgenePNPLA8

GO:0008219

cell death

15695510

HgenePNPLA8

GO:0019369

arachidonic acid metabolic process

10833412|15695510

HgenePNPLA8

GO:0034638

phosphatidylcholine catabolic process

15695510

HgenePNPLA8

GO:0043651

linoleic acid metabolic process

15695510

HgenePNPLA8

GO:0046338

phosphatidylethanolamine catabolic process

15695510

HgenePNPLA8

GO:0050482

arachidonic acid secretion

10833412|15695510

TgeneCFTR

GO:0015701

bicarbonate transport

15010471|19019741

TgeneCFTR

GO:0034976

response to endoplasmic reticulum stress

21884936|28067262

TgeneCFTR

GO:1902476

chloride transmembrane transport

11524016|11707463|19019741

TgeneCFTR

GO:1902943

positive regulation of voltage-gated chloride channel activity

22006324

TgeneCFTR

GO:1904322

cellular response to forskolin

15010471|19621064


check buttonFusion gene breakpoints across PNPLA8 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CFTR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-RC-A6M6-01APNPLA8chr7

108128203

-CFTRchr7

117282492

+


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Fusion Gene ORF analysis for PNPLA8-CFTR

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000257694ENST00000608965PNPLA8chr7

108128203

-CFTRchr7

117282492

+
5CDS-intronENST00000422087ENST00000608965PNPLA8chr7

108128203

-CFTRchr7

117282492

+
5CDS-intronENST00000436062ENST00000608965PNPLA8chr7

108128203

-CFTRchr7

117282492

+
5CDS-intronENST00000453144ENST00000608965PNPLA8chr7

108128203

-CFTRchr7

117282492

+
Frame-shiftENST00000257694ENST00000003084PNPLA8chr7

108128203

-CFTRchr7

117282492

+
Frame-shiftENST00000257694ENST00000454343PNPLA8chr7

108128203

-CFTRchr7

117282492

+
Frame-shiftENST00000436062ENST00000003084PNPLA8chr7

108128203

-CFTRchr7

117282492

+
Frame-shiftENST00000436062ENST00000454343PNPLA8chr7

108128203

-CFTRchr7

117282492

+
In-frameENST00000422087ENST00000003084PNPLA8chr7

108128203

-CFTRchr7

117282492

+
In-frameENST00000422087ENST00000454343PNPLA8chr7

108128203

-CFTRchr7

117282492

+
In-frameENST00000453144ENST00000003084PNPLA8chr7

108128203

-CFTRchr7

117282492

+
In-frameENST00000453144ENST00000454343PNPLA8chr7

108128203

-CFTRchr7

117282492

+
intron-3CDSENST00000388728ENST00000003084PNPLA8chr7

108128203

-CFTRchr7

117282492

+
intron-3CDSENST00000388728ENST00000454343PNPLA8chr7

108128203

-CFTRchr7

117282492

+
intron-3CDSENST00000426128ENST00000003084PNPLA8chr7

108128203

-CFTRchr7

117282492

+
intron-3CDSENST00000426128ENST00000454343PNPLA8chr7

108128203

-CFTRchr7

117282492

+
intron-3CDSENST00000483879ENST00000003084PNPLA8chr7

108128203

-CFTRchr7

117282492

+
intron-3CDSENST00000483879ENST00000454343PNPLA8chr7

108128203

-CFTRchr7

117282492

+
intron-intronENST00000388728ENST00000608965PNPLA8chr7

108128203

-CFTRchr7

117282492

+
intron-intronENST00000426128ENST00000608965PNPLA8chr7

108128203

-CFTRchr7

117282492

+
intron-intronENST00000483879ENST00000608965PNPLA8chr7

108128203

-CFTRchr7

117282492

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000422087PNPLA8chr7108128203-ENST00000003084CFTRchr7117282492+456422854073010867
ENST00000422087PNPLA8chr7108128203-ENST00000454343CFTRchr7117282492+456822854073010867
ENST00000453144PNPLA8chr7108128203-ENST00000003084CFTRchr7117282492+440021212702846858
ENST00000453144PNPLA8chr7108128203-ENST00000454343CFTRchr7117282492+440421212702846858

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000422087ENST00000003084PNPLA8chr7108128203-CFTRchr7117282492+0.0002009670.9997991
ENST00000422087ENST00000454343PNPLA8chr7108128203-CFTRchr7117282492+0.0001983620.9998017
ENST00000453144ENST00000003084PNPLA8chr7108128203-CFTRchr7117282492+0.000394590.9996055
ENST00000453144ENST00000454343PNPLA8chr7108128203-CFTRchr7117282492+0.0003889120.9996111

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Fusion Genomic Features for PNPLA8-CFTR


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PNPLA8chr7108128202-CFTRchr7117282491+0.0009948540.99900514
PNPLA8chr7108128202-CFTRchr7117282491+0.0009948540.99900514

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PNPLA8-CFTR


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:108128203/chr7:117282492)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CFTR

P13569

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis (PubMed:26823428). Mediates the transport of chloride ions across the cell membrane (PubMed:10792060, PubMed:11524016, PubMed:11707463, PubMed:12519745, PubMed:15010471, PubMed:12588899, PubMed:17036051, PubMed:19398555, PubMed:19621064, PubMed:22178883, PubMed:25330774, PubMed:1712898, PubMed:8910473, PubMed:9804160, PubMed:12529365, PubMed:17182731, PubMed:26846474, PubMed:28087700). Channel activity is coupled to ATP hydrolysis (PubMed:8910473). The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration (PubMed:15010471, PubMed:19019741). Exerts its function also by modulating the activity of other ion channels and transporters (PubMed:12403779, PubMed:22178883, PubMed:22121115, PubMed:27941075). Plays an important role in airway fluid homeostasis (PubMed:16645176, PubMed:19621064, PubMed:26823428). Contributes to the regulation of the pH and the ion content of the airway surface fluid layer and thereby plays an important role in defense against pathogens (PubMed:14668433, PubMed:16645176, PubMed:26823428). Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex (PubMed:17434346, PubMed:27941075, PubMed:17182731). Inhibits the activity of the ENaC channel containing subunits SCNN1A, SCNN1B and SCNN1G (PubMed:17182731). Inhibits the activity of the ENaC channel containing subunits SCNN1D, SCNN1B and SCNN1G, but not of the ENaC channel containing subunits SCNN1A, SCNN1B and SCNN1G (PubMed:27941075). May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7 (PubMed:12403779). Can inhibit the chloride channel activity of ANO1 (PubMed:22178883). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (PubMed:19923167, PubMed:27714810). {ECO:0000269|PubMed:10792060, ECO:0000269|PubMed:11524016, ECO:0000269|PubMed:11707463, ECO:0000269|PubMed:12403779, ECO:0000269|PubMed:12519745, ECO:0000269|PubMed:12529365, ECO:0000269|PubMed:12588899, ECO:0000269|PubMed:14668433, ECO:0000269|PubMed:15010471, ECO:0000269|PubMed:16645176, ECO:0000269|PubMed:17036051, ECO:0000269|PubMed:1712898, ECO:0000269|PubMed:17182731, ECO:0000269|PubMed:19019741, ECO:0000269|PubMed:19398555, ECO:0000269|PubMed:19621064, ECO:0000269|PubMed:22178883, ECO:0000269|PubMed:25330774, ECO:0000269|PubMed:26627831, ECO:0000269|PubMed:26823428, ECO:0000269|PubMed:26846474, ECO:0000269|PubMed:27714810, ECO:0000269|PubMed:27941075, ECO:0000269|PubMed:28087700, ECO:0000269|PubMed:8910473, ECO:0000269|PubMed:9804160, ECO:0000305|PubMed:19923167}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePNPLA8chr7:108128203chr7:117282492ENST00000257694-911449_454626783.0MotifGXGXXG
HgenePNPLA8chr7:108128203chr7:117282492ENST00000257694-911481_485626783.0MotifGXSXG
HgenePNPLA8chr7:108128203chr7:117282492ENST00000257694-911627_629626783.0MotifDGA/G
HgenePNPLA8chr7:108128203chr7:117282492ENST00000422087-1012449_454626783.0MotifGXGXXG
HgenePNPLA8chr7:108128203chr7:117282492ENST00000422087-1012481_485626783.0MotifGXSXG
HgenePNPLA8chr7:108128203chr7:117282492ENST00000422087-1012627_629626783.0MotifDGA/G
HgenePNPLA8chr7:108128203chr7:117282492ENST00000436062-810449_454626783.0MotifGXGXXG
HgenePNPLA8chr7:108128203chr7:117282492ENST00000436062-810481_485626783.0MotifGXSXG
HgenePNPLA8chr7:108128203chr7:117282492ENST00000436062-810627_629626783.0MotifDGA/G
HgenePNPLA8chr7:108128203chr7:117282492ENST00000453144-810449_454526683.0MotifGXGXXG
HgenePNPLA8chr7:108128203chr7:117282492ENST00000453144-810481_485526683.0MotifGXSXG
HgenePNPLA8chr7:108128203chr7:117282492ENST00000257694-911475_495626783.0TransmembraneHelical
HgenePNPLA8chr7:108128203chr7:117282492ENST00000422087-1012475_495626783.0TransmembraneHelical
HgenePNPLA8chr7:108128203chr7:117282492ENST00000436062-810475_495626783.0TransmembraneHelical
HgenePNPLA8chr7:108128203chr7:117282492ENST00000453144-810475_495526683.0TransmembraneHelical
TgeneCFTRchr7:108128203chr7:117282492ENST0000045434320261210_144311781420.0DomainABC transporter 2
TgeneCFTRchr7:108128203chr7:117282492ENST0000000308421271244_125112391481.0Nucleotide bindingATP 2
TgeneCFTRchr7:108128203chr7:117282492ENST0000045434320261244_125111781420.0Nucleotide bindingATP 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePNPLA8chr7:108128203chr7:117282492ENST00000257694-911445_640626783.0DomainPNPLA
HgenePNPLA8chr7:108128203chr7:117282492ENST00000422087-1012445_640626783.0DomainPNPLA
HgenePNPLA8chr7:108128203chr7:117282492ENST00000426128-110445_6400721.0DomainPNPLA
HgenePNPLA8chr7:108128203chr7:117282492ENST00000436062-810445_640626783.0DomainPNPLA
HgenePNPLA8chr7:108128203chr7:117282492ENST00000453144-810445_640526683.0DomainPNPLA
HgenePNPLA8chr7:108128203chr7:117282492ENST00000426128-110449_4540721.0MotifGXGXXG
HgenePNPLA8chr7:108128203chr7:117282492ENST00000426128-110481_4850721.0MotifGXSXG
HgenePNPLA8chr7:108128203chr7:117282492ENST00000426128-110627_6290721.0MotifDGA/G
HgenePNPLA8chr7:108128203chr7:117282492ENST00000453144-810627_629526683.0MotifDGA/G
HgenePNPLA8chr7:108128203chr7:117282492ENST00000426128-110475_4950721.0TransmembraneHelical
TgeneCFTRchr7:108128203chr7:117282492ENST0000000308421271210_144312391481.0DomainABC transporter 2
TgeneCFTRchr7:108128203chr7:117282492ENST000000030842127423_64612391481.0DomainABC transporter 1
TgeneCFTRchr7:108128203chr7:117282492ENST00000003084212781_36512391481.0DomainABC transmembrane type-1 1
TgeneCFTRchr7:108128203chr7:117282492ENST000000030842127859_115512391481.0DomainABC transmembrane type-1 2
TgeneCFTRchr7:108128203chr7:117282492ENST000004543432026423_64611781420.0DomainABC transporter 1
TgeneCFTRchr7:108128203chr7:117282492ENST00000454343202681_36511781420.0DomainABC transmembrane type-1 1
TgeneCFTRchr7:108128203chr7:117282492ENST000004543432026859_115511781420.0DomainABC transmembrane type-1 2
TgeneCFTRchr7:108128203chr7:117282492ENST000000030842127458_46512391481.0Nucleotide bindingATP 1
TgeneCFTRchr7:108128203chr7:117282492ENST000004543432026458_46511781420.0Nucleotide bindingATP 1
TgeneCFTRchr7:108128203chr7:117282492ENST000000030842127654_83112391481.0RegionIntrinsically disordered R region
TgeneCFTRchr7:108128203chr7:117282492ENST000004543432026654_83111781420.0RegionIntrinsically disordered R region
TgeneCFTRchr7:108128203chr7:117282492ENST0000000308421271012_101312391481.0Topological domainExtracellular
TgeneCFTRchr7:108128203chr7:117282492ENST0000000308421271035_109512391481.0Topological domainCytoplasmic
TgeneCFTRchr7:108128203chr7:117282492ENST0000000308421271117_113012391481.0Topological domainExtracellular
TgeneCFTRchr7:108128203chr7:117282492ENST0000000308421271152_148012391481.0Topological domainCytoplasmic
TgeneCFTRchr7:108128203chr7:117282492ENST000000030842127147_19512391481.0Topological domainCytoplasmic
TgeneCFTRchr7:108128203chr7:117282492ENST0000000308421271_7712391481.0Topological domainCytoplasmic
TgeneCFTRchr7:108128203chr7:117282492ENST000000030842127217_22212391481.0Topological domainExtracellular
TgeneCFTRchr7:108128203chr7:117282492ENST000000030842127244_29812391481.0Topological domainCytoplasmic
TgeneCFTRchr7:108128203chr7:117282492ENST000000030842127320_33912391481.0Topological domainExtracellular
TgeneCFTRchr7:108128203chr7:117282492ENST000000030842127359_85812391481.0Topological domainCytoplasmic
TgeneCFTRchr7:108128203chr7:117282492ENST000000030842127880_91812391481.0Topological domainExtracellular
TgeneCFTRchr7:108128203chr7:117282492ENST000000030842127940_99012391481.0Topological domainCytoplasmic
TgeneCFTRchr7:108128203chr7:117282492ENST00000003084212799_12212391481.0Topological domainExtracellular
TgeneCFTRchr7:108128203chr7:117282492ENST0000045434320261012_101311781420.0Topological domainExtracellular
TgeneCFTRchr7:108128203chr7:117282492ENST0000045434320261035_109511781420.0Topological domainCytoplasmic
TgeneCFTRchr7:108128203chr7:117282492ENST0000045434320261117_113011781420.0Topological domainExtracellular
TgeneCFTRchr7:108128203chr7:117282492ENST0000045434320261152_148011781420.0Topological domainCytoplasmic
TgeneCFTRchr7:108128203chr7:117282492ENST000004543432026147_19511781420.0Topological domainCytoplasmic
TgeneCFTRchr7:108128203chr7:117282492ENST0000045434320261_7711781420.0Topological domainCytoplasmic
TgeneCFTRchr7:108128203chr7:117282492ENST000004543432026217_22211781420.0Topological domainExtracellular
TgeneCFTRchr7:108128203chr7:117282492ENST000004543432026244_29811781420.0Topological domainCytoplasmic
TgeneCFTRchr7:108128203chr7:117282492ENST000004543432026320_33911781420.0Topological domainExtracellular
TgeneCFTRchr7:108128203chr7:117282492ENST000004543432026359_85811781420.0Topological domainCytoplasmic
TgeneCFTRchr7:108128203chr7:117282492ENST000004543432026880_91811781420.0Topological domainExtracellular
TgeneCFTRchr7:108128203chr7:117282492ENST000004543432026940_99011781420.0Topological domainCytoplasmic
TgeneCFTRchr7:108128203chr7:117282492ENST00000454343202699_12211781420.0Topological domainExtracellular
TgeneCFTRchr7:108128203chr7:117282492ENST0000000308421271014_103412391481.0TransmembraneHelical%3B Name%3D10
TgeneCFTRchr7:108128203chr7:117282492ENST0000000308421271096_111612391481.0TransmembraneHelical%3B Name%3D11
TgeneCFTRchr7:108128203chr7:117282492ENST0000000308421271131_115112391481.0TransmembraneHelical%3B Name%3D12
TgeneCFTRchr7:108128203chr7:117282492ENST000000030842127123_14612391481.0TransmembraneHelical%3B Name%3D2
TgeneCFTRchr7:108128203chr7:117282492ENST000000030842127196_21612391481.0TransmembraneHelical%3B Name%3D3
TgeneCFTRchr7:108128203chr7:117282492ENST000000030842127223_24312391481.0TransmembraneHelical%3B Name%3D4
TgeneCFTRchr7:108128203chr7:117282492ENST000000030842127299_31912391481.0TransmembraneHelical%3B Name%3D5
TgeneCFTRchr7:108128203chr7:117282492ENST000000030842127340_35812391481.0TransmembraneHelical%3B Name%3D6
TgeneCFTRchr7:108128203chr7:117282492ENST00000003084212778_9812391481.0TransmembraneHelical%3B Name%3D1
TgeneCFTRchr7:108128203chr7:117282492ENST000000030842127859_87912391481.0TransmembraneHelical%3B Name%3D7
TgeneCFTRchr7:108128203chr7:117282492ENST000000030842127919_93912391481.0TransmembraneDiscontinuously helical%3B Name%3D8
TgeneCFTRchr7:108128203chr7:117282492ENST000000030842127991_101112391481.0TransmembraneHelical%3B Name%3D9
TgeneCFTRchr7:108128203chr7:117282492ENST0000045434320261014_103411781420.0TransmembraneHelical%3B Name%3D10
TgeneCFTRchr7:108128203chr7:117282492ENST0000045434320261096_111611781420.0TransmembraneHelical%3B Name%3D11
TgeneCFTRchr7:108128203chr7:117282492ENST0000045434320261131_115111781420.0TransmembraneHelical%3B Name%3D12
TgeneCFTRchr7:108128203chr7:117282492ENST000004543432026123_14611781420.0TransmembraneHelical%3B Name%3D2
TgeneCFTRchr7:108128203chr7:117282492ENST000004543432026196_21611781420.0TransmembraneHelical%3B Name%3D3
TgeneCFTRchr7:108128203chr7:117282492ENST000004543432026223_24311781420.0TransmembraneHelical%3B Name%3D4
TgeneCFTRchr7:108128203chr7:117282492ENST000004543432026299_31911781420.0TransmembraneHelical%3B Name%3D5
TgeneCFTRchr7:108128203chr7:117282492ENST000004543432026340_35811781420.0TransmembraneHelical%3B Name%3D6
TgeneCFTRchr7:108128203chr7:117282492ENST00000454343202678_9811781420.0TransmembraneHelical%3B Name%3D1
TgeneCFTRchr7:108128203chr7:117282492ENST000004543432026859_87911781420.0TransmembraneHelical%3B Name%3D7
TgeneCFTRchr7:108128203chr7:117282492ENST000004543432026919_93911781420.0TransmembraneDiscontinuously helical%3B Name%3D8
TgeneCFTRchr7:108128203chr7:117282492ENST000004543432026991_101111781420.0TransmembraneHelical%3B Name%3D9


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Fusion Gene Sequence for PNPLA8-CFTR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>66785_66785_1_PNPLA8-CFTR_PNPLA8_chr7_108128203_ENST00000422087_CFTR_chr7_117282492_ENST00000003084_length(transcript)=4564nt_BP=2285nt
ACTTCCGCTGGGGGCGGAGCGGGGCGGGGCTGAGTGGGTGGCGACCTAGCTGCTGCGCCAGTGTTTGTGTTGGAAGCTCAGCTGATGCAG
GCCGGTTGGAGTGGACGTCATTGCCGGGAACGAGCGAGTCGCCGCTGCAGCCCTAGTGACTGCGGCCTGCATCCCGATTGTCTTCTCCTC
CAAGGTCTACATGATTACCTGAAGTTTAATAATTTTGCCTTTCTAGAGTGTTATACAGCTGGAATCATACTGCTATGGTCCGAATGTTTG
TGCCTCTCAAAATTCATGTGGAAATCATAACCGCTAAAGTGATGGTATTAAGAGGTAAGACCATGAATTATGGCATTTCTTAAATGAAGC
GTTCAAGAAGTGAGAGAATGTCATAGAAAATAAATGATTTTTAAGTTATGTCTATTAATCTGACTGTAGATATATATATTTACCTCCTTA
GTAATGCAAGAAGTGTTTGTGGGAAGCAGAGAAGCAAGCAACTGTATTTCTTGTTCTCACCTAAGCATTACTGGAGGATAAGCCACATCA
GTCTACAAAGAGGTTTTCATACAAACATAATAAGATGTAAATGGACCAAAAGTGAAGCACATTCTTGCAGTAAGCACTGTTACTCTCCAA
GCAACCATGGTTTACATATTGGGATTTTGAAACTTAGCACTTCTGCTCCCAAGGGACTTACAAAAGTGAACATTTGTATGTCCCGTATTA
AAAGTACTTTGAACTCTGTTTCAAAGGCTGTTTTTGGCAATCAAAATGAAATGATTTCACGTTTAGCTCAATTTAAGCCAAGTTCCCAAA
TTTTAAGAAAAGTATCGGATAGTGGCTGGTTAAAACAGAAAAACATCAAACAAGCCATCAAATCTCTGAAAAAATATAGTGACAAATCAG
CAGAAAAGAGTCCTTTTCCAGAAGAGAAAAGTCACATTATAGACAAAGAAGAAGATATAGGTAAACGCAGTCTTTTTCATTACACAAGTT
CTATAACCACAAAATTTGGAGACTCATTCTACTTTTTATCAAATCATATTAATTCATATTTCAAACGTAAGGAAAAAATGTCTCAACAAA
AGGAAAATGAACATTTCCGGGACAAATCAGAACTTGAAGATAAAAAGGTAGAAGAGGGGAAATTAAGATCTCCAGATCCTGGCATCCTGG
CTTATAAGCCAGGCTCAGAATCTGTACATACGGTGGACAAGCCTACAAGTCCTTCTGCGATACCTGATGTTCTTCAAGTTTCAACTAAAC
AAAGTATTGCTAACTTTCTTTCTCGTCCCACGGAAGGTGTACAAGCTTTAGTAGGTGGTTATATTGGTGGACTTGTCCCCAAATTAAAGT
ATGATTCAAAGAGTCAGTCAGAAGAACAGGAAGAGCCTGCTAAAACTGATCAGGCTGTCAGCAAAGACAGAAATGCAGAGGAGAAAAAGC
GTTTATCTCTTCAGCGAGAAAAGATTATCGCAAGGGTGAGTATTGATAACAGGACCCGGGCATTAGTTCAGGCATTAAGAAGAACAACTG
ACCCAAAGCTCTGCATTACTAGGGTTGAAGAACTGACTTTTCATCTTCTAGAATTTCCTGAAGGAAAAGGAGTGGCTGTCAAGGAAAGAA
TTATTCCATATTTATTACGACTGAGACAAATTAAGGATGAAACTCTTCAGGCTGCAGTTAGAGAAATTTTGGCCCTAATTGGCTATGTGG
ATCCAGTGAAAGGGAGAGGAATCCGAATTCTCTCAATTGATGGTGGAGGAACAAGGGGCGTGGTTGCTCTCCAGACCCTACGAAAATTAG
TTGAACTTACTCAGAAGCCAGTTCATCAGCTCTTTGATTACATTTGTGGTGTAAGCACAGGTGCCATATTAGCTTTCATGTTGGGGTTGT
TTCATATGCCCTTGGATGAATGTGAGGAACTTTATCGAAAATTAGGATCAGATGTATTTTCACAAAATGTCATTGTTGGAACAGTAAAAA
TGAGTTGGAGCCATGCATTTTATGACAGTCAAACATGGGAAAACATTCTTAAGGATAGGATGGGATCTGCACTGATGATTGAAACAGCAA
GAAACCCCACATGTCCTAAGGTAGCTGCTGTAAGTACCATAGTAAATAGAGGGATAACACCCAAAGCTTTTGTGTTCAGAAACTATGGTC
ATTTTCCTGGAATCAACTCTCATTATTTGGGAGGCTGTCAGTATAAAATGTGGCAGGCCATTAGAGCCTCATCTGCTGCTCCAGGCTACT
TTGCAGAATATGCATTGGGAAATGATCTTCATCAAGTGGGCCTCTTGGGAAGAACTGGATCAGGGAAGAGTACTTTGTTATCAGCTTTTT
TGAGACTACTGAACACTGAAGGAGAAATCCAGATCGATGGTGTGTCTTGGGATTCAATAACTTTGCAACAGTGGAGGAAAGCCTTTGGAG
TGATACCACAGAAAGTATTTATTTTTTCTGGAACATTTAGAAAAAACTTGGATCCCTATGAACAGTGGAGTGATCAAGAAATATGGAAAG
TTGCAGATGAGGTTGGGCTCAGATCTGTGATAGAACAGTTTCCTGGGAAGCTTGACTTTGTCCTTGTGGATGGGGGCTGTGTCCTAAGCC
ATGGCCACAAGCAGTTGATGTGCTTGGCTAGATCTGTTCTCAGTAAGGCGAAGATCTTGCTGCTTGATGAACCCAGTGCTCATTTGGATC
CAGTAACATACCAAATAATTAGAAGAACTCTAAAACAAGCATTTGCTGATTGCACAGTAATTCTCTGTGAACACAGGATAGAAGCAATGC
TGGAATGCCAACAATTTTTGGTCATAGAAGAGAACAAAGTGCGGCAGTACGATTCCATCCAGAAACTGCTGAACGAGAGGAGCCTCTTCC
GGCAAGCCATCAGCCCCTCCGACAGGGTGAAGCTCTTTCCCCACCGGAACTCAAGCAAGTGCAAGTCTAAGCCCCAGATTGCTGCTCTGA
AAGAGGAGACAGAAGAAGAGGTGCAAGATACAAGGCTTTAGAGAGCAGCATAAATGTTGACATGGGACATTTGCTCATGGAATTGGAGCT
CGTGGGACAGTCACCTCATGGAATTGGAGCTCGTGGAACAGTTACCTCTGCCTCAGAAAACAAGGATGAATTAAGTTTTTTTTTAAAAAA
GAAACATTTGGTAAGGGGAATTGAGGACACTGATATGGGTCTTGATAAATGGCTTCCTGGCAATAGTCAAATTGTGTGAAAGGTACTTCA
AATCCTTGAAGATTTACCACTTGTGTTTTGCAAGCCAGATTTTCCTGAAAACCCTTGCCATGTGCTAGTAATTGGAAAGGCAGCTCTAAA
TGTCAATCAGCCTAGTTGATCAGCTTATTGTCTAGTGAAACTCGTTAATTTGTAGTGTTGGAGAAGAACTGAAATCATACTTCTTAGGGT
TATGATTAAGTAATGATAACTGGAAACTTCAGCGGTTTATATAAGCTTGTATTCCTTTTTCTCTCCTCTCCCCATGATGTTTAGAAACAC
AACTATATTGTTTGCTAAGCATTCCAACTATCTCATTTCCAAGCAAGTATTAGAATACCACAGGAACCACAAGACTGCACATCAAAATAT
GCCCCATTCAACATCTAGTGAGCAGTCAGGAAAGAGAACTTCCAGATCCTGGAAATCAGGGTTAGTATTGTCCAGGTCTACCAAAAATCT
CAATATTTCAGATAATCACAATACATCCCTTACCTGGGAAAGGGCTGTTATAATCTTTCACAGGGGACAGGATGGTTCCCTTGATGAAGA
AGTTGATATGCCTTTTCCCAACTCCAGAAAGTGACAAGCTCACAGACCTTTGAACTAGAGTTTAGCTGGAAAAGTATGTTAGTGCAAATT
GTCACAGGACAGCCCTTCTTTCCACAGAAGCTCCAGGTAGAGGGTGTGTAAGTAGATAGGCCATGGGCACTGTGGGTAGACACACATGAA
GTCCAAGCATTTAGATGTATAGGTTGATGGTGGTATGTTTTCAGGCTAGATGTATGTACTTCATGCTGTCTACACTAAGAGAGAATGAGA
GACACACTGAAGAAGCACCAATCATGAATTAGTTTTATATGCTTCTGTTTTATAATTTTGTGAAGCAAAATTTTTTCTCTAGGAAATATT
TATTTTAATAATGTTTCAAACATATATAACAATGCTGTATTTTAAAAGAATGATTATGAATTACATTTGTATAAAATAATTTTTATATTT
GAAATATTGACTTTTTATGGCACTAGTATTTCTATGAAATATTATGTTAAAACTGGGACAGGGGAGAACCTAGGGTGATATTAACCAGGG
GCCATGAATCACCTTTTGGTCTGGAGGGAAGCCTTGGGGCTGATGCAGTTGTTGCCCACAGCTGTATGATTCCCAGCCAGCACAGCCTCT
TAGATGCAGTTCTGAAGAAGATGGTACCACCAGTCTGACTGTTTCCATCAAGGGTACACTGCCTTCTCAACTCCAAACTGACTCTTAAGA

>66785_66785_1_PNPLA8-CFTR_PNPLA8_chr7_108128203_ENST00000422087_CFTR_chr7_117282492_ENST00000003084_length(amino acids)=867AA_BP=626
MSINLTVDIYIYLLSNARSVCGKQRSKQLYFLFSPKHYWRISHISLQRGFHTNIIRCKWTKSEAHSCSKHCYSPSNHGLHIGILKLSTSA
PKGLTKVNICMSRIKSTLNSVSKAVFGNQNEMISRLAQFKPSSQILRKVSDSGWLKQKNIKQAIKSLKKYSDKSAEKSPFPEEKSHIIDK
EEDIGKRSLFHYTSSITTKFGDSFYFLSNHINSYFKRKEKMSQQKENEHFRDKSELEDKKVEEGKLRSPDPGILAYKPGSESVHTVDKPT
SPSAIPDVLQVSTKQSIANFLSRPTEGVQALVGGYIGGLVPKLKYDSKSQSEEQEEPAKTDQAVSKDRNAEEKKRLSLQREKIIARVSID
NRTRALVQALRRTTDPKLCITRVEELTFHLLEFPEGKGVAVKERIIPYLLRLRQIKDETLQAAVREILALIGYVDPVKGRGIRILSIDGG
GTRGVVALQTLRKLVELTQKPVHQLFDYICGVSTGAILAFMLGLFHMPLDECEELYRKLGSDVFSQNVIVGTVKMSWSHAFYDSQTWENI
LKDRMGSALMIETARNPTCPKVAAVSTIVNRGITPKAFVFRNYGHFPGINSHYLGGCQYKMWQAIRASSAAPGYFAEYALGNDLHQVGLL
GRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPG
KLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQ

--------------------------------------------------------------
>66785_66785_2_PNPLA8-CFTR_PNPLA8_chr7_108128203_ENST00000422087_CFTR_chr7_117282492_ENST00000454343_length(transcript)=4568nt_BP=2285nt
ACTTCCGCTGGGGGCGGAGCGGGGCGGGGCTGAGTGGGTGGCGACCTAGCTGCTGCGCCAGTGTTTGTGTTGGAAGCTCAGCTGATGCAG
GCCGGTTGGAGTGGACGTCATTGCCGGGAACGAGCGAGTCGCCGCTGCAGCCCTAGTGACTGCGGCCTGCATCCCGATTGTCTTCTCCTC
CAAGGTCTACATGATTACCTGAAGTTTAATAATTTTGCCTTTCTAGAGTGTTATACAGCTGGAATCATACTGCTATGGTCCGAATGTTTG
TGCCTCTCAAAATTCATGTGGAAATCATAACCGCTAAAGTGATGGTATTAAGAGGTAAGACCATGAATTATGGCATTTCTTAAATGAAGC
GTTCAAGAAGTGAGAGAATGTCATAGAAAATAAATGATTTTTAAGTTATGTCTATTAATCTGACTGTAGATATATATATTTACCTCCTTA
GTAATGCAAGAAGTGTTTGTGGGAAGCAGAGAAGCAAGCAACTGTATTTCTTGTTCTCACCTAAGCATTACTGGAGGATAAGCCACATCA
GTCTACAAAGAGGTTTTCATACAAACATAATAAGATGTAAATGGACCAAAAGTGAAGCACATTCTTGCAGTAAGCACTGTTACTCTCCAA
GCAACCATGGTTTACATATTGGGATTTTGAAACTTAGCACTTCTGCTCCCAAGGGACTTACAAAAGTGAACATTTGTATGTCCCGTATTA
AAAGTACTTTGAACTCTGTTTCAAAGGCTGTTTTTGGCAATCAAAATGAAATGATTTCACGTTTAGCTCAATTTAAGCCAAGTTCCCAAA
TTTTAAGAAAAGTATCGGATAGTGGCTGGTTAAAACAGAAAAACATCAAACAAGCCATCAAATCTCTGAAAAAATATAGTGACAAATCAG
CAGAAAAGAGTCCTTTTCCAGAAGAGAAAAGTCACATTATAGACAAAGAAGAAGATATAGGTAAACGCAGTCTTTTTCATTACACAAGTT
CTATAACCACAAAATTTGGAGACTCATTCTACTTTTTATCAAATCATATTAATTCATATTTCAAACGTAAGGAAAAAATGTCTCAACAAA
AGGAAAATGAACATTTCCGGGACAAATCAGAACTTGAAGATAAAAAGGTAGAAGAGGGGAAATTAAGATCTCCAGATCCTGGCATCCTGG
CTTATAAGCCAGGCTCAGAATCTGTACATACGGTGGACAAGCCTACAAGTCCTTCTGCGATACCTGATGTTCTTCAAGTTTCAACTAAAC
AAAGTATTGCTAACTTTCTTTCTCGTCCCACGGAAGGTGTACAAGCTTTAGTAGGTGGTTATATTGGTGGACTTGTCCCCAAATTAAAGT
ATGATTCAAAGAGTCAGTCAGAAGAACAGGAAGAGCCTGCTAAAACTGATCAGGCTGTCAGCAAAGACAGAAATGCAGAGGAGAAAAAGC
GTTTATCTCTTCAGCGAGAAAAGATTATCGCAAGGGTGAGTATTGATAACAGGACCCGGGCATTAGTTCAGGCATTAAGAAGAACAACTG
ACCCAAAGCTCTGCATTACTAGGGTTGAAGAACTGACTTTTCATCTTCTAGAATTTCCTGAAGGAAAAGGAGTGGCTGTCAAGGAAAGAA
TTATTCCATATTTATTACGACTGAGACAAATTAAGGATGAAACTCTTCAGGCTGCAGTTAGAGAAATTTTGGCCCTAATTGGCTATGTGG
ATCCAGTGAAAGGGAGAGGAATCCGAATTCTCTCAATTGATGGTGGAGGAACAAGGGGCGTGGTTGCTCTCCAGACCCTACGAAAATTAG
TTGAACTTACTCAGAAGCCAGTTCATCAGCTCTTTGATTACATTTGTGGTGTAAGCACAGGTGCCATATTAGCTTTCATGTTGGGGTTGT
TTCATATGCCCTTGGATGAATGTGAGGAACTTTATCGAAAATTAGGATCAGATGTATTTTCACAAAATGTCATTGTTGGAACAGTAAAAA
TGAGTTGGAGCCATGCATTTTATGACAGTCAAACATGGGAAAACATTCTTAAGGATAGGATGGGATCTGCACTGATGATTGAAACAGCAA
GAAACCCCACATGTCCTAAGGTAGCTGCTGTAAGTACCATAGTAAATAGAGGGATAACACCCAAAGCTTTTGTGTTCAGAAACTATGGTC
ATTTTCCTGGAATCAACTCTCATTATTTGGGAGGCTGTCAGTATAAAATGTGGCAGGCCATTAGAGCCTCATCTGCTGCTCCAGGCTACT
TTGCAGAATATGCATTGGGAAATGATCTTCATCAAGTGGGCCTCTTGGGAAGAACTGGATCAGGGAAGAGTACTTTGTTATCAGCTTTTT
TGAGACTACTGAACACTGAAGGAGAAATCCAGATCGATGGTGTGTCTTGGGATTCAATAACTTTGCAACAGTGGAGGAAAGCCTTTGGAG
TGATACCACAGAAAGTATTTATTTTTTCTGGAACATTTAGAAAAAACTTGGATCCCTATGAACAGTGGAGTGATCAAGAAATATGGAAAG
TTGCAGATGAGGTTGGGCTCAGATCTGTGATAGAACAGTTTCCTGGGAAGCTTGACTTTGTCCTTGTGGATGGGGGCTGTGTCCTAAGCC
ATGGCCACAAGCAGTTGATGTGCTTGGCTAGATCTGTTCTCAGTAAGGCGAAGATCTTGCTGCTTGATGAACCCAGTGCTCATTTGGATC
CAGTAACATACCAAATAATTAGAAGAACTCTAAAACAAGCATTTGCTGATTGCACAGTAATTCTCTGTGAACACAGGATAGAAGCAATGC
TGGAATGCCAACAATTTTTGGTCATAGAAGAGAACAAAGTGCGGCAGTACGATTCCATCCAGAAACTGCTGAACGAGAGGAGCCTCTTCC
GGCAAGCCATCAGCCCCTCCGACAGGGTGAAGCTCTTTCCCCACCGGAACTCAAGCAAGTGCAAGTCTAAGCCCCAGATTGCTGCTCTGA
AAGAGGAGACAGAAGAAGAGGTGCAAGATACAAGGCTTTAGAGAGCAGCATAAATGTTGACATGGGACATTTGCTCATGGAATTGGAGCT
CGTGGGACAGTCACCTCATGGAATTGGAGCTCGTGGAACAGTTACCTCTGCCTCAGAAAACAAGGATGAATTAAGTTTTTTTTTAAAAAA
GAAACATTTGGTAAGGGGAATTGAGGACACTGATATGGGTCTTGATAAATGGCTTCCTGGCAATAGTCAAATTGTGTGAAAGGTACTTCA
AATCCTTGAAGATTTACCACTTGTGTTTTGCAAGCCAGATTTTCCTGAAAACCCTTGCCATGTGCTAGTAATTGGAAAGGCAGCTCTAAA
TGTCAATCAGCCTAGTTGATCAGCTTATTGTCTAGTGAAACTCGTTAATTTGTAGTGTTGGAGAAGAACTGAAATCATACTTCTTAGGGT
TATGATTAAGTAATGATAACTGGAAACTTCAGCGGTTTATATAAGCTTGTATTCCTTTTTCTCTCCTCTCCCCATGATGTTTAGAAACAC
AACTATATTGTTTGCTAAGCATTCCAACTATCTCATTTCCAAGCAAGTATTAGAATACCACAGGAACCACAAGACTGCACATCAAAATAT
GCCCCATTCAACATCTAGTGAGCAGTCAGGAAAGAGAACTTCCAGATCCTGGAAATCAGGGTTAGTATTGTCCAGGTCTACCAAAAATCT
CAATATTTCAGATAATCACAATACATCCCTTACCTGGGAAAGGGCTGTTATAATCTTTCACAGGGGACAGGATGGTTCCCTTGATGAAGA
AGTTGATATGCCTTTTCCCAACTCCAGAAAGTGACAAGCTCACAGACCTTTGAACTAGAGTTTAGCTGGAAAAGTATGTTAGTGCAAATT
GTCACAGGACAGCCCTTCTTTCCACAGAAGCTCCAGGTAGAGGGTGTGTAAGTAGATAGGCCATGGGCACTGTGGGTAGACACACATGAA
GTCCAAGCATTTAGATGTATAGGTTGATGGTGGTATGTTTTCAGGCTAGATGTATGTACTTCATGCTGTCTACACTAAGAGAGAATGAGA
GACACACTGAAGAAGCACCAATCATGAATTAGTTTTATATGCTTCTGTTTTATAATTTTGTGAAGCAAAATTTTTTCTCTAGGAAATATT
TATTTTAATAATGTTTCAAACATATATAACAATGCTGTATTTTAAAAGAATGATTATGAATTACATTTGTATAAAATAATTTTTATATTT
GAAATATTGACTTTTTATGGCACTAGTATTTCTATGAAATATTATGTTAAAACTGGGACAGGGGAGAACCTAGGGTGATATTAACCAGGG
GCCATGAATCACCTTTTGGTCTGGAGGGAAGCCTTGGGGCTGATGCAGTTGTTGCCCACAGCTGTATGATTCCCAGCCAGCACAGCCTCT
TAGATGCAGTTCTGAAGAAGATGGTACCACCAGTCTGACTGTTTCCATCAAGGGTACACTGCCTTCTCAACTCCAAACTGACTCTTAAGA

>66785_66785_2_PNPLA8-CFTR_PNPLA8_chr7_108128203_ENST00000422087_CFTR_chr7_117282492_ENST00000454343_length(amino acids)=867AA_BP=626
MSINLTVDIYIYLLSNARSVCGKQRSKQLYFLFSPKHYWRISHISLQRGFHTNIIRCKWTKSEAHSCSKHCYSPSNHGLHIGILKLSTSA
PKGLTKVNICMSRIKSTLNSVSKAVFGNQNEMISRLAQFKPSSQILRKVSDSGWLKQKNIKQAIKSLKKYSDKSAEKSPFPEEKSHIIDK
EEDIGKRSLFHYTSSITTKFGDSFYFLSNHINSYFKRKEKMSQQKENEHFRDKSELEDKKVEEGKLRSPDPGILAYKPGSESVHTVDKPT
SPSAIPDVLQVSTKQSIANFLSRPTEGVQALVGGYIGGLVPKLKYDSKSQSEEQEEPAKTDQAVSKDRNAEEKKRLSLQREKIIARVSID
NRTRALVQALRRTTDPKLCITRVEELTFHLLEFPEGKGVAVKERIIPYLLRLRQIKDETLQAAVREILALIGYVDPVKGRGIRILSIDGG
GTRGVVALQTLRKLVELTQKPVHQLFDYICGVSTGAILAFMLGLFHMPLDECEELYRKLGSDVFSQNVIVGTVKMSWSHAFYDSQTWENI
LKDRMGSALMIETARNPTCPKVAAVSTIVNRGITPKAFVFRNYGHFPGINSHYLGGCQYKMWQAIRASSAAPGYFAEYALGNDLHQVGLL
GRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPG
KLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQ

--------------------------------------------------------------
>66785_66785_3_PNPLA8-CFTR_PNPLA8_chr7_108128203_ENST00000453144_CFTR_chr7_117282492_ENST00000003084_length(transcript)=4400nt_BP=2121nt
ATGCTCTATTGCGCATATCTCGGGGCGGGGGAGGAACGGAGATTGACAAGGAGGCAGAGGCCTGAGCGAGGCGGAAAATCCTCACCCCGG
CCCGCGGGTAGACCCAAACTTCTAGCGCGTCACTTCCGCTGGGGGCGGAGCGGGGCGGGGCTGAGTGGGTGGCGACCTAGCTGCTGCGCC
AGTGTTTGTGTTGGAAGCTCAGCTGATGCAGGCCGGTTGGAGTGGACGTCATTGCCGGGAACGAGCGAGTCGCCGCTGCAGCCCTAGTGA
CTGCGGCCTGCATCCCGTAATGCAAGAAGTGTTTGTGGGAAGCAGAGAAGCAAGCAACTGTATTTCTTGTTCTCACCTAAGCATTACTGG
AGGATAAGCCACATCAGTCTACAAAGAGGTTTTCATACAAACATAATAAGATGTAAATGGACCAAAAGTGAAGCACATTCTTGCAGTAAG
CACTGTTACTCTCCAAGCAACCATGGTTTACATATTGGGATTTTGAAACTTAGCACTTCTGCTCCCAAGGGACTTACAAAAGTGAACATT
TGTATGTCCCGTATTAAAAGTACTTTGAACTCTGTTTCAAAGGCTGTTTTTGGCAATCAAAATGAAATGATTTCACGTTTAGCTCAATTT
AAGCCAAGTTCCCAAATTTTAAGAAAAGTATCGGATAGTGGCTGGTTAAAACAGAAAAACATCAAACAAGCCATCAAATCTCTGAAAAAA
TATAGTGACAAATCAGCAGAAAAGAGTCCTTTTCCAGAAGAGAAAAGTCACATTATAGACAAAGAAGAAGATATAGGTAAACGCAGTCTT
TTTCATTACACAAGTTCTATAACCACAAAATTTGGAGACTCATTCTACTTTTTATCAAATCATATTAATTCATATTTCAAACGTAAGGAA
AAAATGTCTCAACAAAAGGAAAATGAACATTTCCGGGACAAATCAGAACTTGAAGATAAAAAGGTAGAAGAGGGGAAATTAAGATCTCCA
GATCCTGGCATCCTGGCTTATAAGCCAGGCTCAGAATCTGTACATACGGTGGACAAGCCTACAAGTCCTTCTGCGATACCTGATGTTCTT
CAAGTTTCAACTAAACAAAGTATTGCTAACTTTCTTTCTCGTCCCACGGAAGGTGTACAAGCTTTAGTAGGTGGTTATATTGGTGGACTT
GTCCCCAAATTAAAGTATGATTCAAAGAGTCAGTCAGAAGAACAGGAAGAGCCTGCTAAAACTGATCAGGCTGTCAGCAAAGACAGAAAT
GCAGAGGAGAAAAAGCGTTTATCTCTTCAGCGAGAAAAGATTATCGCAAGGGTGAGTATTGATAACAGGACCCGGGCATTAGTTCAGGCA
TTAAGAAGAACAACTGACCCAAAGCTCTGCATTACTAGGGTTGAAGAACTGACTTTTCATCTTCTAGAATTTCCTGAAGGAAAAGGAGTG
GCTGTCAAGGAAAGAATTATTCCATATTTATTACGACTGAGACAAATTAAGGATGAAACTCTTCAGGCTGCAGTTAGAGAAATTTTGGCC
CTAATTGGCTATGTGGATCCAGTGAAAGGGAGAGGAATCCGAATTCTCTCAATTGATGGTGGAGGAACAAGGGGCGTGGTTGCTCTCCAG
ACCCTACGAAAATTAGTTGAACTTACTCAGAAGCCAGTTCATCAGCTCTTTGATTACATTTGTGGTGTAAGCACAGGTGCCATATTAGCT
TTCATGTTGGGGTTGTTTCATATGCCCTTGGATGAATGTGAGGAACTTTATCGAAAATTAGGATCAGATGTATTTTCACAAAATGTCATT
GTTGGAACAGTAAAAATGAGTTGGAGCCATGCATTTTATGACAGTCAAACATGGGAAAACATTCTTAAGGATAGGATGGGATCTGCACTG
ATGATTGAAACAGCAAGAAACCCCACATGTCCTAAGGTAGCTGCTGTAAGTACCATAGTAAATAGAGGGATAACACCCAAAGCTTTTGTG
TTCAGAAACTATGGTCATTTTCCTGGAATCAACTCTCATTATTTGGGAGGCTGTCAGTATAAAATGTGGCAGGCCATTAGAGCCTCATCT
GCTGCTCCAGGCTACTTTGCAGAATATGCATTGGGAAATGATCTTCATCAAGTGGGCCTCTTGGGAAGAACTGGATCAGGGAAGAGTACT
TTGTTATCAGCTTTTTTGAGACTACTGAACACTGAAGGAGAAATCCAGATCGATGGTGTGTCTTGGGATTCAATAACTTTGCAACAGTGG
AGGAAAGCCTTTGGAGTGATACCACAGAAAGTATTTATTTTTTCTGGAACATTTAGAAAAAACTTGGATCCCTATGAACAGTGGAGTGAT
CAAGAAATATGGAAAGTTGCAGATGAGGTTGGGCTCAGATCTGTGATAGAACAGTTTCCTGGGAAGCTTGACTTTGTCCTTGTGGATGGG
GGCTGTGTCCTAAGCCATGGCCACAAGCAGTTGATGTGCTTGGCTAGATCTGTTCTCAGTAAGGCGAAGATCTTGCTGCTTGATGAACCC
AGTGCTCATTTGGATCCAGTAACATACCAAATAATTAGAAGAACTCTAAAACAAGCATTTGCTGATTGCACAGTAATTCTCTGTGAACAC
AGGATAGAAGCAATGCTGGAATGCCAACAATTTTTGGTCATAGAAGAGAACAAAGTGCGGCAGTACGATTCCATCCAGAAACTGCTGAAC
GAGAGGAGCCTCTTCCGGCAAGCCATCAGCCCCTCCGACAGGGTGAAGCTCTTTCCCCACCGGAACTCAAGCAAGTGCAAGTCTAAGCCC
CAGATTGCTGCTCTGAAAGAGGAGACAGAAGAAGAGGTGCAAGATACAAGGCTTTAGAGAGCAGCATAAATGTTGACATGGGACATTTGC
TCATGGAATTGGAGCTCGTGGGACAGTCACCTCATGGAATTGGAGCTCGTGGAACAGTTACCTCTGCCTCAGAAAACAAGGATGAATTAA
GTTTTTTTTTAAAAAAGAAACATTTGGTAAGGGGAATTGAGGACACTGATATGGGTCTTGATAAATGGCTTCCTGGCAATAGTCAAATTG
TGTGAAAGGTACTTCAAATCCTTGAAGATTTACCACTTGTGTTTTGCAAGCCAGATTTTCCTGAAAACCCTTGCCATGTGCTAGTAATTG
GAAAGGCAGCTCTAAATGTCAATCAGCCTAGTTGATCAGCTTATTGTCTAGTGAAACTCGTTAATTTGTAGTGTTGGAGAAGAACTGAAA
TCATACTTCTTAGGGTTATGATTAAGTAATGATAACTGGAAACTTCAGCGGTTTATATAAGCTTGTATTCCTTTTTCTCTCCTCTCCCCA
TGATGTTTAGAAACACAACTATATTGTTTGCTAAGCATTCCAACTATCTCATTTCCAAGCAAGTATTAGAATACCACAGGAACCACAAGA
CTGCACATCAAAATATGCCCCATTCAACATCTAGTGAGCAGTCAGGAAAGAGAACTTCCAGATCCTGGAAATCAGGGTTAGTATTGTCCA
GGTCTACCAAAAATCTCAATATTTCAGATAATCACAATACATCCCTTACCTGGGAAAGGGCTGTTATAATCTTTCACAGGGGACAGGATG
GTTCCCTTGATGAAGAAGTTGATATGCCTTTTCCCAACTCCAGAAAGTGACAAGCTCACAGACCTTTGAACTAGAGTTTAGCTGGAAAAG
TATGTTAGTGCAAATTGTCACAGGACAGCCCTTCTTTCCACAGAAGCTCCAGGTAGAGGGTGTGTAAGTAGATAGGCCATGGGCACTGTG
GGTAGACACACATGAAGTCCAAGCATTTAGATGTATAGGTTGATGGTGGTATGTTTTCAGGCTAGATGTATGTACTTCATGCTGTCTACA
CTAAGAGAGAATGAGAGACACACTGAAGAAGCACCAATCATGAATTAGTTTTATATGCTTCTGTTTTATAATTTTGTGAAGCAAAATTTT
TTCTCTAGGAAATATTTATTTTAATAATGTTTCAAACATATATAACAATGCTGTATTTTAAAAGAATGATTATGAATTACATTTGTATAA
AATAATTTTTATATTTGAAATATTGACTTTTTATGGCACTAGTATTTCTATGAAATATTATGTTAAAACTGGGACAGGGGAGAACCTAGG
GTGATATTAACCAGGGGCCATGAATCACCTTTTGGTCTGGAGGGAAGCCTTGGGGCTGATGCAGTTGTTGCCCACAGCTGTATGATTCCC
AGCCAGCACAGCCTCTTAGATGCAGTTCTGAAGAAGATGGTACCACCAGTCTGACTGTTTCCATCAAGGGTACACTGCCTTCTCAACTCC

>66785_66785_3_PNPLA8-CFTR_PNPLA8_chr7_108128203_ENST00000453144_CFTR_chr7_117282492_ENST00000003084_length(amino acids)=858AA_BP=617
MRPASRNARSVCGKQRSKQLYFLFSPKHYWRISHISLQRGFHTNIIRCKWTKSEAHSCSKHCYSPSNHGLHIGILKLSTSAPKGLTKVNI
CMSRIKSTLNSVSKAVFGNQNEMISRLAQFKPSSQILRKVSDSGWLKQKNIKQAIKSLKKYSDKSAEKSPFPEEKSHIIDKEEDIGKRSL
FHYTSSITTKFGDSFYFLSNHINSYFKRKEKMSQQKENEHFRDKSELEDKKVEEGKLRSPDPGILAYKPGSESVHTVDKPTSPSAIPDVL
QVSTKQSIANFLSRPTEGVQALVGGYIGGLVPKLKYDSKSQSEEQEEPAKTDQAVSKDRNAEEKKRLSLQREKIIARVSIDNRTRALVQA
LRRTTDPKLCITRVEELTFHLLEFPEGKGVAVKERIIPYLLRLRQIKDETLQAAVREILALIGYVDPVKGRGIRILSIDGGGTRGVVALQ
TLRKLVELTQKPVHQLFDYICGVSTGAILAFMLGLFHMPLDECEELYRKLGSDVFSQNVIVGTVKMSWSHAFYDSQTWENILKDRMGSAL
MIETARNPTCPKVAAVSTIVNRGITPKAFVFRNYGHFPGINSHYLGGCQYKMWQAIRASSAAPGYFAEYALGNDLHQVGLLGRTGSGKST
LLSAFLRLLNTEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDG
GCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLN

--------------------------------------------------------------
>66785_66785_4_PNPLA8-CFTR_PNPLA8_chr7_108128203_ENST00000453144_CFTR_chr7_117282492_ENST00000454343_length(transcript)=4404nt_BP=2121nt
ATGCTCTATTGCGCATATCTCGGGGCGGGGGAGGAACGGAGATTGACAAGGAGGCAGAGGCCTGAGCGAGGCGGAAAATCCTCACCCCGG
CCCGCGGGTAGACCCAAACTTCTAGCGCGTCACTTCCGCTGGGGGCGGAGCGGGGCGGGGCTGAGTGGGTGGCGACCTAGCTGCTGCGCC
AGTGTTTGTGTTGGAAGCTCAGCTGATGCAGGCCGGTTGGAGTGGACGTCATTGCCGGGAACGAGCGAGTCGCCGCTGCAGCCCTAGTGA
CTGCGGCCTGCATCCCGTAATGCAAGAAGTGTTTGTGGGAAGCAGAGAAGCAAGCAACTGTATTTCTTGTTCTCACCTAAGCATTACTGG
AGGATAAGCCACATCAGTCTACAAAGAGGTTTTCATACAAACATAATAAGATGTAAATGGACCAAAAGTGAAGCACATTCTTGCAGTAAG
CACTGTTACTCTCCAAGCAACCATGGTTTACATATTGGGATTTTGAAACTTAGCACTTCTGCTCCCAAGGGACTTACAAAAGTGAACATT
TGTATGTCCCGTATTAAAAGTACTTTGAACTCTGTTTCAAAGGCTGTTTTTGGCAATCAAAATGAAATGATTTCACGTTTAGCTCAATTT
AAGCCAAGTTCCCAAATTTTAAGAAAAGTATCGGATAGTGGCTGGTTAAAACAGAAAAACATCAAACAAGCCATCAAATCTCTGAAAAAA
TATAGTGACAAATCAGCAGAAAAGAGTCCTTTTCCAGAAGAGAAAAGTCACATTATAGACAAAGAAGAAGATATAGGTAAACGCAGTCTT
TTTCATTACACAAGTTCTATAACCACAAAATTTGGAGACTCATTCTACTTTTTATCAAATCATATTAATTCATATTTCAAACGTAAGGAA
AAAATGTCTCAACAAAAGGAAAATGAACATTTCCGGGACAAATCAGAACTTGAAGATAAAAAGGTAGAAGAGGGGAAATTAAGATCTCCA
GATCCTGGCATCCTGGCTTATAAGCCAGGCTCAGAATCTGTACATACGGTGGACAAGCCTACAAGTCCTTCTGCGATACCTGATGTTCTT
CAAGTTTCAACTAAACAAAGTATTGCTAACTTTCTTTCTCGTCCCACGGAAGGTGTACAAGCTTTAGTAGGTGGTTATATTGGTGGACTT
GTCCCCAAATTAAAGTATGATTCAAAGAGTCAGTCAGAAGAACAGGAAGAGCCTGCTAAAACTGATCAGGCTGTCAGCAAAGACAGAAAT
GCAGAGGAGAAAAAGCGTTTATCTCTTCAGCGAGAAAAGATTATCGCAAGGGTGAGTATTGATAACAGGACCCGGGCATTAGTTCAGGCA
TTAAGAAGAACAACTGACCCAAAGCTCTGCATTACTAGGGTTGAAGAACTGACTTTTCATCTTCTAGAATTTCCTGAAGGAAAAGGAGTG
GCTGTCAAGGAAAGAATTATTCCATATTTATTACGACTGAGACAAATTAAGGATGAAACTCTTCAGGCTGCAGTTAGAGAAATTTTGGCC
CTAATTGGCTATGTGGATCCAGTGAAAGGGAGAGGAATCCGAATTCTCTCAATTGATGGTGGAGGAACAAGGGGCGTGGTTGCTCTCCAG
ACCCTACGAAAATTAGTTGAACTTACTCAGAAGCCAGTTCATCAGCTCTTTGATTACATTTGTGGTGTAAGCACAGGTGCCATATTAGCT
TTCATGTTGGGGTTGTTTCATATGCCCTTGGATGAATGTGAGGAACTTTATCGAAAATTAGGATCAGATGTATTTTCACAAAATGTCATT
GTTGGAACAGTAAAAATGAGTTGGAGCCATGCATTTTATGACAGTCAAACATGGGAAAACATTCTTAAGGATAGGATGGGATCTGCACTG
ATGATTGAAACAGCAAGAAACCCCACATGTCCTAAGGTAGCTGCTGTAAGTACCATAGTAAATAGAGGGATAACACCCAAAGCTTTTGTG
TTCAGAAACTATGGTCATTTTCCTGGAATCAACTCTCATTATTTGGGAGGCTGTCAGTATAAAATGTGGCAGGCCATTAGAGCCTCATCT
GCTGCTCCAGGCTACTTTGCAGAATATGCATTGGGAAATGATCTTCATCAAGTGGGCCTCTTGGGAAGAACTGGATCAGGGAAGAGTACT
TTGTTATCAGCTTTTTTGAGACTACTGAACACTGAAGGAGAAATCCAGATCGATGGTGTGTCTTGGGATTCAATAACTTTGCAACAGTGG
AGGAAAGCCTTTGGAGTGATACCACAGAAAGTATTTATTTTTTCTGGAACATTTAGAAAAAACTTGGATCCCTATGAACAGTGGAGTGAT
CAAGAAATATGGAAAGTTGCAGATGAGGTTGGGCTCAGATCTGTGATAGAACAGTTTCCTGGGAAGCTTGACTTTGTCCTTGTGGATGGG
GGCTGTGTCCTAAGCCATGGCCACAAGCAGTTGATGTGCTTGGCTAGATCTGTTCTCAGTAAGGCGAAGATCTTGCTGCTTGATGAACCC
AGTGCTCATTTGGATCCAGTAACATACCAAATAATTAGAAGAACTCTAAAACAAGCATTTGCTGATTGCACAGTAATTCTCTGTGAACAC
AGGATAGAAGCAATGCTGGAATGCCAACAATTTTTGGTCATAGAAGAGAACAAAGTGCGGCAGTACGATTCCATCCAGAAACTGCTGAAC
GAGAGGAGCCTCTTCCGGCAAGCCATCAGCCCCTCCGACAGGGTGAAGCTCTTTCCCCACCGGAACTCAAGCAAGTGCAAGTCTAAGCCC
CAGATTGCTGCTCTGAAAGAGGAGACAGAAGAAGAGGTGCAAGATACAAGGCTTTAGAGAGCAGCATAAATGTTGACATGGGACATTTGC
TCATGGAATTGGAGCTCGTGGGACAGTCACCTCATGGAATTGGAGCTCGTGGAACAGTTACCTCTGCCTCAGAAAACAAGGATGAATTAA
GTTTTTTTTTAAAAAAGAAACATTTGGTAAGGGGAATTGAGGACACTGATATGGGTCTTGATAAATGGCTTCCTGGCAATAGTCAAATTG
TGTGAAAGGTACTTCAAATCCTTGAAGATTTACCACTTGTGTTTTGCAAGCCAGATTTTCCTGAAAACCCTTGCCATGTGCTAGTAATTG
GAAAGGCAGCTCTAAATGTCAATCAGCCTAGTTGATCAGCTTATTGTCTAGTGAAACTCGTTAATTTGTAGTGTTGGAGAAGAACTGAAA
TCATACTTCTTAGGGTTATGATTAAGTAATGATAACTGGAAACTTCAGCGGTTTATATAAGCTTGTATTCCTTTTTCTCTCCTCTCCCCA
TGATGTTTAGAAACACAACTATATTGTTTGCTAAGCATTCCAACTATCTCATTTCCAAGCAAGTATTAGAATACCACAGGAACCACAAGA
CTGCACATCAAAATATGCCCCATTCAACATCTAGTGAGCAGTCAGGAAAGAGAACTTCCAGATCCTGGAAATCAGGGTTAGTATTGTCCA
GGTCTACCAAAAATCTCAATATTTCAGATAATCACAATACATCCCTTACCTGGGAAAGGGCTGTTATAATCTTTCACAGGGGACAGGATG
GTTCCCTTGATGAAGAAGTTGATATGCCTTTTCCCAACTCCAGAAAGTGACAAGCTCACAGACCTTTGAACTAGAGTTTAGCTGGAAAAG
TATGTTAGTGCAAATTGTCACAGGACAGCCCTTCTTTCCACAGAAGCTCCAGGTAGAGGGTGTGTAAGTAGATAGGCCATGGGCACTGTG
GGTAGACACACATGAAGTCCAAGCATTTAGATGTATAGGTTGATGGTGGTATGTTTTCAGGCTAGATGTATGTACTTCATGCTGTCTACA
CTAAGAGAGAATGAGAGACACACTGAAGAAGCACCAATCATGAATTAGTTTTATATGCTTCTGTTTTATAATTTTGTGAAGCAAAATTTT
TTCTCTAGGAAATATTTATTTTAATAATGTTTCAAACATATATAACAATGCTGTATTTTAAAAGAATGATTATGAATTACATTTGTATAA
AATAATTTTTATATTTGAAATATTGACTTTTTATGGCACTAGTATTTCTATGAAATATTATGTTAAAACTGGGACAGGGGAGAACCTAGG
GTGATATTAACCAGGGGCCATGAATCACCTTTTGGTCTGGAGGGAAGCCTTGGGGCTGATGCAGTTGTTGCCCACAGCTGTATGATTCCC
AGCCAGCACAGCCTCTTAGATGCAGTTCTGAAGAAGATGGTACCACCAGTCTGACTGTTTCCATCAAGGGTACACTGCCTTCTCAACTCC

>66785_66785_4_PNPLA8-CFTR_PNPLA8_chr7_108128203_ENST00000453144_CFTR_chr7_117282492_ENST00000454343_length(amino acids)=858AA_BP=617
MRPASRNARSVCGKQRSKQLYFLFSPKHYWRISHISLQRGFHTNIIRCKWTKSEAHSCSKHCYSPSNHGLHIGILKLSTSAPKGLTKVNI
CMSRIKSTLNSVSKAVFGNQNEMISRLAQFKPSSQILRKVSDSGWLKQKNIKQAIKSLKKYSDKSAEKSPFPEEKSHIIDKEEDIGKRSL
FHYTSSITTKFGDSFYFLSNHINSYFKRKEKMSQQKENEHFRDKSELEDKKVEEGKLRSPDPGILAYKPGSESVHTVDKPTSPSAIPDVL
QVSTKQSIANFLSRPTEGVQALVGGYIGGLVPKLKYDSKSQSEEQEEPAKTDQAVSKDRNAEEKKRLSLQREKIIARVSIDNRTRALVQA
LRRTTDPKLCITRVEELTFHLLEFPEGKGVAVKERIIPYLLRLRQIKDETLQAAVREILALIGYVDPVKGRGIRILSIDGGGTRGVVALQ
TLRKLVELTQKPVHQLFDYICGVSTGAILAFMLGLFHMPLDECEELYRKLGSDVFSQNVIVGTVKMSWSHAFYDSQTWENILKDRMGSAL
MIETARNPTCPKVAAVSTIVNRGITPKAFVFRNYGHFPGINSHYLGGCQYKMWQAIRASSAAPGYFAEYALGNDLHQVGLLGRTGSGKST
LLSAFLRLLNTEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDG
GCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLN

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PNPLA8-CFTR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneCFTRchr7:108128203chr7:117282492ENST0000000308421271386_14801239.01481.0GORASP2
TgeneCFTRchr7:108128203chr7:117282492ENST0000045434320261386_14801178.01420.0GORASP2


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PNPLA8-CFTR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PNPLA8-CFTR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource