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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARMC8-MRAS (FusionGDB2 ID:6681)

Fusion Gene Summary for ARMC8-MRAS

check button Fusion gene summary
Fusion gene informationFusion gene name: ARMC8-MRAS
Fusion gene ID: 6681
HgeneTgene
Gene symbol

ARMC8

MRAS

Gene ID

25852

22808

Gene namearmadillo repeat containing 8muscle RAS oncogene homolog
SynonymsGID5|HSPC056|S863-2|VID28M-RAs|NS11|R-RAS3|RRAS3
Cytomap

3q22.3

3q22.3

Type of geneprotein-codingprotein-coding
Descriptionarmadillo repeat-containing protein 8GID complex subunit 5, VID28 homologras-related protein M-Rasmuscle and microspikes RASras-related protein R-Ras3
Modification date2020031320200313
UniProtAcc

Q8IUR7

O14807

Ensembl transtripts involved in fusion geneENST00000358441, ENST00000471453, 
ENST00000481646, ENST00000491704, 
ENST00000393058, ENST00000461822, 
ENST00000469044, ENST00000470821, 
ENST00000485396, ENST00000489213, 
ENST00000538260, 		ENST00000289104, 
ENST00000423968, ENST00000474559, 
ENST00000461114, ENST00000464896, 
Fusion gene scores* DoF score11 X 11 X 5=6054 X 4 X 3=48
# samples 134
** MAII scorelog2(13/605*10)=-2.2184235191335
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARMC8 [Title/Abstract] AND MRAS [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARMC8(137907372)-MRAS(138091708), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ARMC8 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across MRAS (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-KK-A8I5-01AARMC8chr3

137907372

+MRASchr3

138091708

+


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Fusion Gene ORF analysis for ARMC8-MRAS

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000358441ENST00000289104ARMC8chr3

137907372

+MRASchr3

138091708

+
5CDS-5UTRENST00000358441ENST00000423968ARMC8chr3

137907372

+MRASchr3

138091708

+
5CDS-5UTRENST00000358441ENST00000474559ARMC8chr3

137907372

+MRASchr3

138091708

+
5CDS-5UTRENST00000471453ENST00000289104ARMC8chr3

137907372

+MRASchr3

138091708

+
5CDS-5UTRENST00000471453ENST00000423968ARMC8chr3

137907372

+MRASchr3

138091708

+
5CDS-5UTRENST00000471453ENST00000474559ARMC8chr3

137907372

+MRASchr3

138091708

+
5CDS-5UTRENST00000481646ENST00000289104ARMC8chr3

137907372

+MRASchr3

138091708

+
5CDS-5UTRENST00000481646ENST00000423968ARMC8chr3

137907372

+MRASchr3

138091708

+
5CDS-5UTRENST00000481646ENST00000474559ARMC8chr3

137907372

+MRASchr3

138091708

+
5CDS-intronENST00000358441ENST00000461114ARMC8chr3

137907372

+MRASchr3

138091708

+
5CDS-intronENST00000358441ENST00000464896ARMC8chr3

137907372

+MRASchr3

138091708

+
5CDS-intronENST00000471453ENST00000461114ARMC8chr3

137907372

+MRASchr3

138091708

+
5CDS-intronENST00000471453ENST00000464896ARMC8chr3

137907372

+MRASchr3

138091708

+
5CDS-intronENST00000481646ENST00000461114ARMC8chr3

137907372

+MRASchr3

138091708

+
5CDS-intronENST00000481646ENST00000464896ARMC8chr3

137907372

+MRASchr3

138091708

+
5UTR-5UTRENST00000491704ENST00000289104ARMC8chr3

137907372

+MRASchr3

138091708

+
5UTR-5UTRENST00000491704ENST00000423968ARMC8chr3

137907372

+MRASchr3

138091708

+
5UTR-5UTRENST00000491704ENST00000474559ARMC8chr3

137907372

+MRASchr3

138091708

+
5UTR-intronENST00000491704ENST00000461114ARMC8chr3

137907372

+MRASchr3

138091708

+
5UTR-intronENST00000491704ENST00000464896ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-5UTRENST00000393058ENST00000289104ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-5UTRENST00000393058ENST00000423968ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-5UTRENST00000393058ENST00000474559ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-5UTRENST00000461822ENST00000289104ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-5UTRENST00000461822ENST00000423968ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-5UTRENST00000461822ENST00000474559ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-5UTRENST00000469044ENST00000289104ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-5UTRENST00000469044ENST00000423968ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-5UTRENST00000469044ENST00000474559ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-5UTRENST00000470821ENST00000289104ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-5UTRENST00000470821ENST00000423968ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-5UTRENST00000470821ENST00000474559ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-5UTRENST00000485396ENST00000289104ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-5UTRENST00000485396ENST00000423968ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-5UTRENST00000485396ENST00000474559ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-5UTRENST00000489213ENST00000289104ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-5UTRENST00000489213ENST00000423968ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-5UTRENST00000489213ENST00000474559ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-5UTRENST00000538260ENST00000289104ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-5UTRENST00000538260ENST00000423968ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-5UTRENST00000538260ENST00000474559ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-intronENST00000393058ENST00000461114ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-intronENST00000393058ENST00000464896ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-intronENST00000461822ENST00000461114ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-intronENST00000461822ENST00000464896ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-intronENST00000469044ENST00000461114ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-intronENST00000469044ENST00000464896ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-intronENST00000470821ENST00000461114ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-intronENST00000470821ENST00000464896ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-intronENST00000485396ENST00000461114ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-intronENST00000485396ENST00000464896ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-intronENST00000489213ENST00000461114ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-intronENST00000489213ENST00000464896ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-intronENST00000538260ENST00000461114ARMC8chr3

137907372

+MRASchr3

138091708

+
intron-intronENST00000538260ENST00000464896ARMC8chr3

137907372

+MRASchr3

138091708

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ARMC8-MRAS


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ARMC8chr3137907372+MRASchr3138091707+6.64E-101
ARMC8chr3137907372+MRASchr3138091707+6.64E-101

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ARMC8-MRAS


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:137907372/:138091708)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARMC8

Q8IUR7

MRAS

O14807

FUNCTION: Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. {ECO:0000269|PubMed:29911972}.FUNCTION: Serves as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Activates the MAP kinase pathway. {ECO:0000269|PubMed:16630891, ECO:0000269|PubMed:28289718}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ARMC8-MRAS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ARMC8-MRAS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARMC8-MRAS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARMC8-MRAS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource