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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:POC1A-TWF2 (FusionGDB2 ID:66813)

Fusion Gene Summary for POC1A-TWF2

check button Fusion gene summary
Fusion gene informationFusion gene name: POC1A-TWF2
Fusion gene ID: 66813
HgeneTgene
Gene symbol

POC1A

TWF2

Gene ID

25886

11344

Gene namePOC1 centriolar protein Atwinfilin actin binding protein 2
SynonymsPIX2|SOFT|WDR51AA6RP|A6r|MSTP011|PTK9L
Cytomap

3p21.2

3p21.2

Type of geneprotein-codingprotein-coding
DescriptionPOC1 centriolar protein homolog AWD repeat domain 51AWD repeat-containing protein 51Aproteome of centriole protein 1Atwinfilin-2A6-related proteinPTK9L protein tyrosine kinase 9-like (A6-related protein)protein tyrosine kinase 9-like (A6-related protein)twinfilin, actin-binding protein, homolog 2twinfilin-1-like protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000296484, ENST00000394970, 
ENST00000474012, 		ENST00000305533, 
ENST00000499914, 
Fusion gene scores* DoF score4 X 4 X 5=803 X 5 X 3=45
# samples 75
** MAII scorelog2(7/80*10)=-0.192645077942396
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/45*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: POC1A [Title/Abstract] AND TWF2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPOC1A(52156395)-TWF2(52265011), # samples:2
POC1A(52172185)-TWF2(52266133), # samples:2
POC1A(52172185)-TWF2(52265555), # samples:2
Anticipated loss of major functional domain due to fusion event.POC1A-TWF2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
POC1A-TWF2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across POC1A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TWF2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-DD-A118-01APOC1Achr3

52156395

-TWF2chr3

52265011

-
ChimerDB4UCECTCGA-PG-A5BC-01APOC1Achr3

52172185

-TWF2chr3

52265555

-
ChimerDB4UCECTCGA-PG-A5BC-01APOC1Achr3

52172185

-TWF2chr3

52266133

-
ChimerDB4UCECTCGA-PG-A5BCPOC1Achr3

52172184

-TWF2chr3

52265555

-


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Fusion Gene ORF analysis for POC1A-TWF2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000296484ENST00000305533POC1Achr3

52172185

-TWF2chr3

52266133

-
Frame-shiftENST00000296484ENST00000499914POC1Achr3

52172185

-TWF2chr3

52266133

-
Frame-shiftENST00000394970ENST00000305533POC1Achr3

52172185

-TWF2chr3

52266133

-
Frame-shiftENST00000394970ENST00000499914POC1Achr3

52172185

-TWF2chr3

52266133

-
Frame-shiftENST00000474012ENST00000305533POC1Achr3

52156395

-TWF2chr3

52265011

-
Frame-shiftENST00000474012ENST00000305533POC1Achr3

52172185

-TWF2chr3

52265555

-
Frame-shiftENST00000474012ENST00000305533POC1Achr3

52172184

-TWF2chr3

52265555

-
Frame-shiftENST00000474012ENST00000499914POC1Achr3

52156395

-TWF2chr3

52265011

-
Frame-shiftENST00000474012ENST00000499914POC1Achr3

52172185

-TWF2chr3

52265555

-
Frame-shiftENST00000474012ENST00000499914POC1Achr3

52172184

-TWF2chr3

52265555

-
In-frameENST00000296484ENST00000305533POC1Achr3

52156395

-TWF2chr3

52265011

-
In-frameENST00000296484ENST00000305533POC1Achr3

52172185

-TWF2chr3

52265555

-
In-frameENST00000296484ENST00000305533POC1Achr3

52172184

-TWF2chr3

52265555

-
In-frameENST00000296484ENST00000499914POC1Achr3

52156395

-TWF2chr3

52265011

-
In-frameENST00000296484ENST00000499914POC1Achr3

52172185

-TWF2chr3

52265555

-
In-frameENST00000296484ENST00000499914POC1Achr3

52172184

-TWF2chr3

52265555

-
In-frameENST00000394970ENST00000305533POC1Achr3

52156395

-TWF2chr3

52265011

-
In-frameENST00000394970ENST00000305533POC1Achr3

52172185

-TWF2chr3

52265555

-
In-frameENST00000394970ENST00000305533POC1Achr3

52172184

-TWF2chr3

52265555

-
In-frameENST00000394970ENST00000499914POC1Achr3

52156395

-TWF2chr3

52265011

-
In-frameENST00000394970ENST00000499914POC1Achr3

52172185

-TWF2chr3

52265555

-
In-frameENST00000394970ENST00000499914POC1Achr3

52172184

-TWF2chr3

52265555

-
In-frameENST00000474012ENST00000305533POC1Achr3

52172185

-TWF2chr3

52266133

-
In-frameENST00000474012ENST00000499914POC1Achr3

52172185

-TWF2chr3

52266133

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000296484POC1Achr352156395-ENST00000305533TWF2chr352265011-20121021401587515
ENST00000296484POC1Achr352156395-ENST00000499914TWF2chr352265011-18521021401302420
ENST00000394970POC1Achr352156395-ENST00000305533TWF2chr352265011-22901299751865596
ENST00000394970POC1Achr352156395-ENST00000499914TWF2chr352265011-21301299751580501

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000296484ENST00000305533POC1Achr352156395-TWF2chr352265011-0.0256181770.9743818
ENST00000296484ENST00000499914POC1Achr352156395-TWF2chr352265011-0.0544728520.94552714
ENST00000394970ENST00000305533POC1Achr352156395-TWF2chr352265011-0.0201935880.9798064
ENST00000394970ENST00000499914POC1Achr352156395-TWF2chr352265011-0.047960390.95203966

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Fusion Genomic Features for POC1A-TWF2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for POC1A-TWF2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:52156395/chr3:52265011)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePOC1Achr3:52156395chr3:52265011ENST00000296484-911101_140327408.0RepeatNote=WD 3
HgenePOC1Achr3:52156395chr3:52265011ENST00000296484-911143_182327408.0RepeatNote=WD 4
HgenePOC1Achr3:52156395chr3:52265011ENST00000296484-91117_56327408.0RepeatNote=WD 1
HgenePOC1Achr3:52156395chr3:52265011ENST00000296484-911185_224327408.0RepeatNote=WD 5
HgenePOC1Achr3:52156395chr3:52265011ENST00000296484-911227_266327408.0RepeatNote=WD 6
HgenePOC1Achr3:52156395chr3:52265011ENST00000296484-911269_308327408.0RepeatNote=WD 7
HgenePOC1Achr3:52156395chr3:52265011ENST00000296484-91159_98327408.0RepeatNote=WD 2
HgenePOC1Achr3:52156395chr3:52265011ENST00000394970-910101_140327360.0RepeatNote=WD 3
HgenePOC1Achr3:52156395chr3:52265011ENST00000394970-910143_182327360.0RepeatNote=WD 4
HgenePOC1Achr3:52156395chr3:52265011ENST00000394970-91017_56327360.0RepeatNote=WD 1
HgenePOC1Achr3:52156395chr3:52265011ENST00000394970-910185_224327360.0RepeatNote=WD 5
HgenePOC1Achr3:52156395chr3:52265011ENST00000394970-910227_266327360.0RepeatNote=WD 6
HgenePOC1Achr3:52156395chr3:52265011ENST00000394970-910269_308327360.0RepeatNote=WD 7
HgenePOC1Achr3:52156395chr3:52265011ENST00000394970-91059_98327360.0RepeatNote=WD 2
HgenePOC1Achr3:52156395chr3:52265011ENST00000474012-911101_140289370.0RepeatNote=WD 3
HgenePOC1Achr3:52156395chr3:52265011ENST00000474012-911143_182289370.0RepeatNote=WD 4
HgenePOC1Achr3:52156395chr3:52265011ENST00000474012-91117_56289370.0RepeatNote=WD 1
HgenePOC1Achr3:52156395chr3:52265011ENST00000474012-911185_224289370.0RepeatNote=WD 5
HgenePOC1Achr3:52156395chr3:52265011ENST00000474012-911227_266289370.0RepeatNote=WD 6
HgenePOC1Achr3:52156395chr3:52265011ENST00000474012-91159_98289370.0RepeatNote=WD 2
HgenePOC1Achr3:52172184chr3:52265555ENST00000296484-711101_140271408.0RepeatNote=WD 3
HgenePOC1Achr3:52172184chr3:52265555ENST00000296484-711143_182271408.0RepeatNote=WD 4
HgenePOC1Achr3:52172184chr3:52265555ENST00000296484-71117_56271408.0RepeatNote=WD 1
HgenePOC1Achr3:52172184chr3:52265555ENST00000296484-711185_224271408.0RepeatNote=WD 5
HgenePOC1Achr3:52172184chr3:52265555ENST00000296484-711227_266271408.0RepeatNote=WD 6
HgenePOC1Achr3:52172184chr3:52265555ENST00000296484-71159_98271408.0RepeatNote=WD 2
HgenePOC1Achr3:52172184chr3:52265555ENST00000394970-710101_140271360.0RepeatNote=WD 3
HgenePOC1Achr3:52172184chr3:52265555ENST00000394970-710143_182271360.0RepeatNote=WD 4
HgenePOC1Achr3:52172184chr3:52265555ENST00000394970-71017_56271360.0RepeatNote=WD 1
HgenePOC1Achr3:52172184chr3:52265555ENST00000394970-710185_224271360.0RepeatNote=WD 5
HgenePOC1Achr3:52172184chr3:52265555ENST00000394970-710227_266271360.0RepeatNote=WD 6
HgenePOC1Achr3:52172184chr3:52265555ENST00000394970-71059_98271360.0RepeatNote=WD 2
HgenePOC1Achr3:52172184chr3:52265555ENST00000474012-711101_140233370.0RepeatNote=WD 3
HgenePOC1Achr3:52172184chr3:52265555ENST00000474012-711143_182233370.0RepeatNote=WD 4
HgenePOC1Achr3:52172184chr3:52265555ENST00000474012-71117_56233370.0RepeatNote=WD 1
HgenePOC1Achr3:52172184chr3:52265555ENST00000474012-711185_224233370.0RepeatNote=WD 5
HgenePOC1Achr3:52172184chr3:52265555ENST00000474012-71159_98233370.0RepeatNote=WD 2
HgenePOC1Achr3:52172185chr3:52265555ENST00000296484-711101_140271408.0RepeatNote=WD 3
HgenePOC1Achr3:52172185chr3:52265555ENST00000296484-711143_182271408.0RepeatNote=WD 4
HgenePOC1Achr3:52172185chr3:52265555ENST00000296484-71117_56271408.0RepeatNote=WD 1
HgenePOC1Achr3:52172185chr3:52265555ENST00000296484-711185_224271408.0RepeatNote=WD 5
HgenePOC1Achr3:52172185chr3:52265555ENST00000296484-711227_266271408.0RepeatNote=WD 6
HgenePOC1Achr3:52172185chr3:52265555ENST00000296484-71159_98271408.0RepeatNote=WD 2
HgenePOC1Achr3:52172185chr3:52265555ENST00000394970-710101_140271360.0RepeatNote=WD 3
HgenePOC1Achr3:52172185chr3:52265555ENST00000394970-710143_182271360.0RepeatNote=WD 4
HgenePOC1Achr3:52172185chr3:52265555ENST00000394970-71017_56271360.0RepeatNote=WD 1
HgenePOC1Achr3:52172185chr3:52265555ENST00000394970-710185_224271360.0RepeatNote=WD 5
HgenePOC1Achr3:52172185chr3:52265555ENST00000394970-710227_266271360.0RepeatNote=WD 6
HgenePOC1Achr3:52172185chr3:52265555ENST00000394970-71059_98271360.0RepeatNote=WD 2
HgenePOC1Achr3:52172185chr3:52265555ENST00000474012-711101_140233370.0RepeatNote=WD 3
HgenePOC1Achr3:52172185chr3:52265555ENST00000474012-711143_182233370.0RepeatNote=WD 4
HgenePOC1Achr3:52172185chr3:52265555ENST00000474012-71117_56233370.0RepeatNote=WD 1
HgenePOC1Achr3:52172185chr3:52265555ENST00000474012-711185_224233370.0RepeatNote=WD 5
HgenePOC1Achr3:52172185chr3:52265555ENST00000474012-71159_98233370.0RepeatNote=WD 2
HgenePOC1Achr3:52172185chr3:52266133ENST00000296484-711101_140271408.0RepeatNote=WD 3
HgenePOC1Achr3:52172185chr3:52266133ENST00000296484-711143_182271408.0RepeatNote=WD 4
HgenePOC1Achr3:52172185chr3:52266133ENST00000296484-71117_56271408.0RepeatNote=WD 1
HgenePOC1Achr3:52172185chr3:52266133ENST00000296484-711185_224271408.0RepeatNote=WD 5
HgenePOC1Achr3:52172185chr3:52266133ENST00000296484-711227_266271408.0RepeatNote=WD 6
HgenePOC1Achr3:52172185chr3:52266133ENST00000296484-71159_98271408.0RepeatNote=WD 2
HgenePOC1Achr3:52172185chr3:52266133ENST00000394970-710101_140271360.0RepeatNote=WD 3
HgenePOC1Achr3:52172185chr3:52266133ENST00000394970-710143_182271360.0RepeatNote=WD 4
HgenePOC1Achr3:52172185chr3:52266133ENST00000394970-71017_56271360.0RepeatNote=WD 1
HgenePOC1Achr3:52172185chr3:52266133ENST00000394970-710185_224271360.0RepeatNote=WD 5
HgenePOC1Achr3:52172185chr3:52266133ENST00000394970-710227_266271360.0RepeatNote=WD 6
HgenePOC1Achr3:52172185chr3:52266133ENST00000394970-71059_98271360.0RepeatNote=WD 2
HgenePOC1Achr3:52172185chr3:52266133ENST00000474012-711101_140233370.0RepeatNote=WD 3
HgenePOC1Achr3:52172185chr3:52266133ENST00000474012-711143_182233370.0RepeatNote=WD 4
HgenePOC1Achr3:52172185chr3:52266133ENST00000474012-71117_56233370.0RepeatNote=WD 1
HgenePOC1Achr3:52172185chr3:52266133ENST00000474012-711185_224233370.0RepeatNote=WD 5
HgenePOC1Achr3:52172185chr3:52266133ENST00000474012-71159_98233370.0RepeatNote=WD 2
TgeneTWF2chr3:52156395chr3:52265011ENST0000030553349177_313161350.0DomainADF-H 2
TgeneTWF2chr3:52172184chr3:52265555ENST0000030553329177_31394350.0DomainADF-H 2
TgeneTWF2chr3:52172185chr3:52265555ENST0000030553329177_31394350.0DomainADF-H 2
TgeneTWF2chr3:52172185chr3:52266133ENST0000030553319177_31334350.0DomainADF-H 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePOC1Achr3:52156395chr3:52265011ENST00000296484-911369_397327408.0Coiled coilOntology_term=ECO:0000255
HgenePOC1Achr3:52156395chr3:52265011ENST00000394970-910369_397327360.0Coiled coilOntology_term=ECO:0000255
HgenePOC1Achr3:52156395chr3:52265011ENST00000474012-911369_397289370.0Coiled coilOntology_term=ECO:0000255
HgenePOC1Achr3:52172184chr3:52265555ENST00000296484-711369_397271408.0Coiled coilOntology_term=ECO:0000255
HgenePOC1Achr3:52172184chr3:52265555ENST00000394970-710369_397271360.0Coiled coilOntology_term=ECO:0000255
HgenePOC1Achr3:52172184chr3:52265555ENST00000474012-711369_397233370.0Coiled coilOntology_term=ECO:0000255
HgenePOC1Achr3:52172185chr3:52265555ENST00000296484-711369_397271408.0Coiled coilOntology_term=ECO:0000255
HgenePOC1Achr3:52172185chr3:52265555ENST00000394970-710369_397271360.0Coiled coilOntology_term=ECO:0000255
HgenePOC1Achr3:52172185chr3:52265555ENST00000474012-711369_397233370.0Coiled coilOntology_term=ECO:0000255
HgenePOC1Achr3:52172185chr3:52266133ENST00000296484-711369_397271408.0Coiled coilOntology_term=ECO:0000255
HgenePOC1Achr3:52172185chr3:52266133ENST00000394970-710369_397271360.0Coiled coilOntology_term=ECO:0000255
HgenePOC1Achr3:52172185chr3:52266133ENST00000474012-711369_397233370.0Coiled coilOntology_term=ECO:0000255
HgenePOC1Achr3:52156395chr3:52265011ENST00000474012-911269_308289370.0RepeatNote=WD 7
HgenePOC1Achr3:52172184chr3:52265555ENST00000296484-711269_308271408.0RepeatNote=WD 7
HgenePOC1Achr3:52172184chr3:52265555ENST00000394970-710269_308271360.0RepeatNote=WD 7
HgenePOC1Achr3:52172184chr3:52265555ENST00000474012-711227_266233370.0RepeatNote=WD 6
HgenePOC1Achr3:52172184chr3:52265555ENST00000474012-711269_308233370.0RepeatNote=WD 7
HgenePOC1Achr3:52172185chr3:52265555ENST00000296484-711269_308271408.0RepeatNote=WD 7
HgenePOC1Achr3:52172185chr3:52265555ENST00000394970-710269_308271360.0RepeatNote=WD 7
HgenePOC1Achr3:52172185chr3:52265555ENST00000474012-711227_266233370.0RepeatNote=WD 6
HgenePOC1Achr3:52172185chr3:52265555ENST00000474012-711269_308233370.0RepeatNote=WD 7
HgenePOC1Achr3:52172185chr3:52266133ENST00000296484-711269_308271408.0RepeatNote=WD 7
HgenePOC1Achr3:52172185chr3:52266133ENST00000394970-710269_308271360.0RepeatNote=WD 7
HgenePOC1Achr3:52172185chr3:52266133ENST00000474012-711227_266233370.0RepeatNote=WD 6
HgenePOC1Achr3:52172185chr3:52266133ENST00000474012-711269_308233370.0RepeatNote=WD 7
TgeneTWF2chr3:52156395chr3:52265011ENST00000305533494_139161350.0DomainADF-H 1
TgeneTWF2chr3:52172184chr3:52265555ENST00000305533294_13994350.0DomainADF-H 1
TgeneTWF2chr3:52172185chr3:52265555ENST00000305533294_13994350.0DomainADF-H 1
TgeneTWF2chr3:52172185chr3:52266133ENST00000305533194_13934350.0DomainADF-H 1


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Fusion Gene Sequence for POC1A-TWF2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>66813_66813_1_POC1A-TWF2_POC1A_chr3_52156395_ENST00000296484_TWF2_chr3_52265011_ENST00000305533_length(transcript)=2012nt_BP=1021nt
AACGGCCACCGCAGCTGCCTTCGGCGCCGCCAGCCCCGCCATGGCTGCGCCCTGCGCGGAGGACCCCTCGCTGGAAAGGCATTTTAAGGG
CCACCGAGATGCAGTTACCTGTGTGGACTTCAGTATCAACACAAAGCAGCTGGCCAGTGGCTCCATGGACTCATGCCTCATGGTCTGGCA
CATGAAGCCGCAGTCACGCGCCTACCGCTTCACTGGCCACAAGGATGCCGTCACCTGTGTGAACTTCTCTCCTTCGGGACACCTGCTTGC
TTCCGGCTCCCGAGACAAGACTGTCCGCATCTGGGTACCCAATGTCAAAGGTGAGTCCACTGTGTTTCGTGCACACACAGCCACAGTGAG
GAGTGTCCACTTCTGCAGTGATGGCCAGTCCTTCGTGACAGCCTCTGACGACAAGACAGTCAAAGTGTGGGCAACTCATCGCCAGAAATT
CCTGTTCTCCCTGAGCCAGCATATCAACTGGGTCCGCTGTGCCAAGTTCTCCCCCGACGGGCGGCTCATCGTGTCTGCCAGTGATGACAA
GACTGTTAAGCTGTGGGACAAGAGCAGCCGGGAATGTGTCCACTCGTATTGTGAGCATGGCGGCTTTGTCACCTATGTGGACTTCCACCC
CAGTGGGACGTGCATTGCCGCTGCCGGCATGGACAACACAGTGAAGGTGTGGGACGTGCGGACTCACCGGCTGCTGCAGCATTATCAGTT
GCACAGTGCAGCAGTGAACGGGCTCTCTTTCCACCCGTCGGGAAACTACCTGATCACAGCCTCCAGTGACTCAACCCTGAAGATCCTGGA
CCTGATGGAGGGCCGGCTGCTCTACACACTCCACGGGCATCAGGGACCAGCCACCACTGTTGCCTTTTCAAGAACGGGGGAGTATTTTGC
TTCTGGAGGCTCTGATGAACAAGTGATGGTTTGGAAGAGTAACTTTGATATTGTTGATCATGGAGAAGTCACGAAAGTGCCGAGGCCCCC
AGCCACACTGGCCAGCTCCATGGGGAATCTGGTGAAGACAGAGATCAGTGTGGAAAGCAAGCACCAGACCCTGCAGGGCCTCGCCTTCCC
CCTGCAGCCTGAGGCCCAGCGGGCACTCCAGCAGCTCAAGCAGAAAATGGTCAACTACATCCAGATGAAGCTGGACCTAGAGCGGGAAAC
CATTGAGCTGGTGCACACAGAGCCCACGGATGTGGCCCAGCTGCCCTCCCGGGTGCCCCGAGATGCTGCCCGCTACCACTTCTTCCTCTA
CAAGCACACCCATGAGGGCGACCCCCTTGAGTCTGTAGTGTTCATCTACTCCATGCCGGGGTACAAGTGCAGCATCAAGGAGCGAATGCT
CTACTCCAGCTGCAAGAGCCGCCTCCTCGACTCCGTGGAGCAGGACTTCCATCTGGAGATCGCCAAGAAAATTGAGATTGGCGATGGGGC
AGAGCTGACGGCAGAGTTCCTCTACGACGAGGTGCACCCCAAGCAACACGCCTTCAAGCAGGCCTTCGCCAAGCCCAAGGGCCCAGGGGG
CAAGCGGGGCCATAAGCGCCTCATCCGCGGCCCGGGTGAAAATGGGGATGACAGCTAGGAGGCTGGAGCAGGGCCGGCCACGTGTGGACT
GTGGGGCTGCCCACCTTCCGCTCCCTGCCACCATCCTCCTTCCTGGGCTCCAGGAAAGTGTTTCTGGGAGGTCAGGAGGGCTGGCAGCTG
AACGCACTTGCAGCGTCCGAGGGCCACCGGGCTGGCATTTTGTGACCCTTCCCTGTTGCTGTCCCTGCATCTCGTCTGTGTGCCCAGGGT
GTCCGGGGACCCTGCCTGGCTGGCTTAAGGGGGCTGGGTCAGGGGCCTGGCATGAACCTGGCCTCCCGGGGAGCTGAGACTAGGGTCCCA
GCACAGCCCAGAAACCTTTGGCCACAAGAAGTGGGGTCAGTCAGGGCTGGGGCAGGGGTCACTGCAGTTTGGGATGGTTGAATGCTGTAT

>66813_66813_1_POC1A-TWF2_POC1A_chr3_52156395_ENST00000296484_TWF2_chr3_52265011_ENST00000305533_length(amino acids)=515AA_BP=327
MAAPCAEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVP
NVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECV
HSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGH
QGPATTVAFSRTGEYFASGGSDEQVMVWKSNFDIVDHGEVTKVPRPPATLASSMGNLVKTEISVESKHQTLQGLAFPLQPEAQRALQQLK
QKMVNYIQMKLDLERETIELVHTEPTDVAQLPSRVPRDAARYHFFLYKHTHEGDPLESVVFIYSMPGYKCSIKERMLYSSCKSRLLDSVE

--------------------------------------------------------------
>66813_66813_2_POC1A-TWF2_POC1A_chr3_52156395_ENST00000296484_TWF2_chr3_52265011_ENST00000499914_length(transcript)=1852nt_BP=1021nt
AACGGCCACCGCAGCTGCCTTCGGCGCCGCCAGCCCCGCCATGGCTGCGCCCTGCGCGGAGGACCCCTCGCTGGAAAGGCATTTTAAGGG
CCACCGAGATGCAGTTACCTGTGTGGACTTCAGTATCAACACAAAGCAGCTGGCCAGTGGCTCCATGGACTCATGCCTCATGGTCTGGCA
CATGAAGCCGCAGTCACGCGCCTACCGCTTCACTGGCCACAAGGATGCCGTCACCTGTGTGAACTTCTCTCCTTCGGGACACCTGCTTGC
TTCCGGCTCCCGAGACAAGACTGTCCGCATCTGGGTACCCAATGTCAAAGGTGAGTCCACTGTGTTTCGTGCACACACAGCCACAGTGAG
GAGTGTCCACTTCTGCAGTGATGGCCAGTCCTTCGTGACAGCCTCTGACGACAAGACAGTCAAAGTGTGGGCAACTCATCGCCAGAAATT
CCTGTTCTCCCTGAGCCAGCATATCAACTGGGTCCGCTGTGCCAAGTTCTCCCCCGACGGGCGGCTCATCGTGTCTGCCAGTGATGACAA
GACTGTTAAGCTGTGGGACAAGAGCAGCCGGGAATGTGTCCACTCGTATTGTGAGCATGGCGGCTTTGTCACCTATGTGGACTTCCACCC
CAGTGGGACGTGCATTGCCGCTGCCGGCATGGACAACACAGTGAAGGTGTGGGACGTGCGGACTCACCGGCTGCTGCAGCATTATCAGTT
GCACAGTGCAGCAGTGAACGGGCTCTCTTTCCACCCGTCGGGAAACTACCTGATCACAGCCTCCAGTGACTCAACCCTGAAGATCCTGGA
CCTGATGGAGGGCCGGCTGCTCTACACACTCCACGGGCATCAGGGACCAGCCACCACTGTTGCCTTTTCAAGAACGGGGGAGTATTTTGC
TTCTGGAGGCTCTGATGAACAAGTGATGGTTTGGAAGAGTAACTTTGATATTGTTGATCATGGAGAAGTCACGAAAGTGCCGAGGCCCCC
AGCCACACTGGCCAGCTCCATGGGGAATCTGGTGAAGACAGAGATCAGTGTGGAAAGCAAGCACCAGACCCTGCAGGGCCTCGCCTTCCC
CCTGCAGCCTGAGGCCCAGCGGGCACTCCAGCAGCTCAAGCAGAAAATGGTCAACTACATCCAGATGAAGCTGGACCTAGAGCGGGAAAC
CATTGAGCTGGTGCACACAGAGCCCACGGATGTGGCCCAGCTGCCCTCCCGGGTGCCCCGAGATGCTGCCCGCTACCACTTCTTCCTCTA
CAAGCACACCCATGAGGGCGACCCCCTTGAGTCTGTAGATTGAGATTGGCGATGGGGCAGAGCTGACGGCAGAGTTCCTCTACGACGAGG
TGCACCCCAAGCAACACGCCTTCAAGCAGGCCTTCGCCAAGCCCAAGGGCCCAGGGGGCAAGCGGGGCCATAAGCGCCTCATCCGCGGCC
CGGGTGAAAATGGGGATGACAGCTAGGAGGCTGGAGCAGGGCCGGCCACGTGTGGACTGTGGGGCTGCCCACCTTCCGCTCCCTGCCACC
ATCCTCCTTCCTGGGCTCCAGGAAAGTGTTTCTGGGAGGTCAGGAGGGCTGGCAGCTGAACGCACTTGCAGCGTCCGAGGGCCACCGGGC
TGGCATTTTGTGACCCTTCCCTGTTGCTGTCCCTGCATCTCGTCTGTGTGCCCAGGGTGTCCGGGGACCCTGCCTGGCTGGCTTAAGGGG
GCTGGGTCAGGGGCCTGGCATGAACCTGGCCTCCCGGGGAGCTGAGACTAGGGTCCCAGCACAGCCCAGAAACCTTTGGCCACAAGAAGT

>66813_66813_2_POC1A-TWF2_POC1A_chr3_52156395_ENST00000296484_TWF2_chr3_52265011_ENST00000499914_length(amino acids)=420AA_BP=327
MAAPCAEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVP
NVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECV
HSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGH
QGPATTVAFSRTGEYFASGGSDEQVMVWKSNFDIVDHGEVTKVPRPPATLASSMGNLVKTEISVESKHQTLQGLAFPLQPEAQRALQQLK

--------------------------------------------------------------
>66813_66813_3_POC1A-TWF2_POC1A_chr3_52156395_ENST00000394970_TWF2_chr3_52265011_ENST00000305533_length(transcript)=2290nt_BP=1299nt
GGGCTGGTGGGGTGAACCCTTCATCCTGGGTCTTTTAATTTCTCAGGCGGAACGAGTGGCGGCGGACAGAGGCTTTTGGCTGCGCTGTCT
GTGGGTTGTCTGGGCTTGGGGAACTGGGCACGGAGACCGTGGCGCCGGCCGCCGGTCATACAGCTCTGCTTCCAGTCGTCGGGCAAAAAG
CTGAGGCGCTTCTCCTTTAATTGCGGTGGGCGGGGCGTGCCGACGCGGCCCGCGTTGCTATTGGTGGCCGTTGGGGGCGCGGAAACTGAA
CGGGCCGCAACGGCCACCGCAGCTGCCTTCGGCGCCGCCAGCCCCGCCATGGCTGCGCCCTGCGCGGAGGACCCCTCGCTGGAAAGGCAT
TTTAAGGGCCACCGAGATGCAGTTACCTGTGTGGACTTCAGTATCAACACAAAGCAGCTGGCCAGTGGCTCCATGGACTCATGCCTCATG
GTCTGGCACATGAAGCCGCAGTCACGCGCCTACCGCTTCACTGGCCACAAGGATGCCGTCACCTGTGTGAACTTCTCTCCTTCGGGACAC
CTGCTTGCTTCCGGCTCCCGAGACAAGACTGTCCGCATCTGGGTACCCAATGTCAAAGGTGAGTCCACTGTGTTTCGTGCACACACAGCC
ACAGTGAGGAGTGTCCACTTCTGCAGTGATGGCCAGTCCTTCGTGACAGCCTCTGACGACAAGACAGTCAAAGTGTGGGCAACTCATCGC
CAGAAATTCCTGTTCTCCCTGAGCCAGCATATCAACTGGGTCCGCTGTGCCAAGTTCTCCCCCGACGGGCGGCTCATCGTGTCTGCCAGT
GATGACAAGACTGTTAAGCTGTGGGACAAGAGCAGCCGGGAATGTGTCCACTCGTATTGTGAGCATGGCGGCTTTGTCACCTATGTGGAC
TTCCACCCCAGTGGGACGTGCATTGCCGCTGCCGGCATGGACAACACAGTGAAGGTGTGGGACGTGCGGACTCACCGGCTGCTGCAGCAT
TATCAGTTGCACAGTGCAGCAGTGAACGGGCTCTCTTTCCACCCGTCGGGAAACTACCTGATCACAGCCTCCAGTGACTCAACCCTGAAG
ATCCTGGACCTGATGGAGGGCCGGCTGCTCTACACACTCCACGGGCATCAGGGACCAGCCACCACTGTTGCCTTTTCAAGAACGGGGGAG
TATTTTGCTTCTGGAGGCTCTGATGAACAAGTGATGGTTTGGAAGAGTAACTTTGATATTGTTGATCATGGAGAAGTCACGAAAGTGCCG
AGGCCCCCAGCCACACTGGCCAGCTCCATGGGGAATCTGGTGAAGACAGAGATCAGTGTGGAAAGCAAGCACCAGACCCTGCAGGGCCTC
GCCTTCCCCCTGCAGCCTGAGGCCCAGCGGGCACTCCAGCAGCTCAAGCAGAAAATGGTCAACTACATCCAGATGAAGCTGGACCTAGAG
CGGGAAACCATTGAGCTGGTGCACACAGAGCCCACGGATGTGGCCCAGCTGCCCTCCCGGGTGCCCCGAGATGCTGCCCGCTACCACTTC
TTCCTCTACAAGCACACCCATGAGGGCGACCCCCTTGAGTCTGTAGTGTTCATCTACTCCATGCCGGGGTACAAGTGCAGCATCAAGGAG
CGAATGCTCTACTCCAGCTGCAAGAGCCGCCTCCTCGACTCCGTGGAGCAGGACTTCCATCTGGAGATCGCCAAGAAAATTGAGATTGGC
GATGGGGCAGAGCTGACGGCAGAGTTCCTCTACGACGAGGTGCACCCCAAGCAACACGCCTTCAAGCAGGCCTTCGCCAAGCCCAAGGGC
CCAGGGGGCAAGCGGGGCCATAAGCGCCTCATCCGCGGCCCGGGTGAAAATGGGGATGACAGCTAGGAGGCTGGAGCAGGGCCGGCCACG
TGTGGACTGTGGGGCTGCCCACCTTCCGCTCCCTGCCACCATCCTCCTTCCTGGGCTCCAGGAAAGTGTTTCTGGGAGGTCAGGAGGGCT
GGCAGCTGAACGCACTTGCAGCGTCCGAGGGCCACCGGGCTGGCATTTTGTGACCCTTCCCTGTTGCTGTCCCTGCATCTCGTCTGTGTG
CCCAGGGTGTCCGGGGACCCTGCCTGGCTGGCTTAAGGGGGCTGGGTCAGGGGCCTGGCATGAACCTGGCCTCCCGGGGAGCTGAGACTA
GGGTCCCAGCACAGCCCAGAAACCTTTGGCCACAAGAAGTGGGGTCAGTCAGGGCTGGGGCAGGGGTCACTGCAGTTTGGGATGGTTGAA

>66813_66813_3_POC1A-TWF2_POC1A_chr3_52156395_ENST00000394970_TWF2_chr3_52265011_ENST00000305533_length(amino acids)=596AA_BP=408
MAALSVGCLGLGNWARRPWRRPPVIQLCFQSSGKKLRRFSFNCGGRGVPTRPALLLVAVGGAETERAATATAAAFGAASPAMAAPCAEDP
SLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF
RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGF
VTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAF
SRTGEYFASGGSDEQVMVWKSNFDIVDHGEVTKVPRPPATLASSMGNLVKTEISVESKHQTLQGLAFPLQPEAQRALQQLKQKMVNYIQM
KLDLERETIELVHTEPTDVAQLPSRVPRDAARYHFFLYKHTHEGDPLESVVFIYSMPGYKCSIKERMLYSSCKSRLLDSVEQDFHLEIAK

--------------------------------------------------------------
>66813_66813_4_POC1A-TWF2_POC1A_chr3_52156395_ENST00000394970_TWF2_chr3_52265011_ENST00000499914_length(transcript)=2130nt_BP=1299nt
GGGCTGGTGGGGTGAACCCTTCATCCTGGGTCTTTTAATTTCTCAGGCGGAACGAGTGGCGGCGGACAGAGGCTTTTGGCTGCGCTGTCT
GTGGGTTGTCTGGGCTTGGGGAACTGGGCACGGAGACCGTGGCGCCGGCCGCCGGTCATACAGCTCTGCTTCCAGTCGTCGGGCAAAAAG
CTGAGGCGCTTCTCCTTTAATTGCGGTGGGCGGGGCGTGCCGACGCGGCCCGCGTTGCTATTGGTGGCCGTTGGGGGCGCGGAAACTGAA
CGGGCCGCAACGGCCACCGCAGCTGCCTTCGGCGCCGCCAGCCCCGCCATGGCTGCGCCCTGCGCGGAGGACCCCTCGCTGGAAAGGCAT
TTTAAGGGCCACCGAGATGCAGTTACCTGTGTGGACTTCAGTATCAACACAAAGCAGCTGGCCAGTGGCTCCATGGACTCATGCCTCATG
GTCTGGCACATGAAGCCGCAGTCACGCGCCTACCGCTTCACTGGCCACAAGGATGCCGTCACCTGTGTGAACTTCTCTCCTTCGGGACAC
CTGCTTGCTTCCGGCTCCCGAGACAAGACTGTCCGCATCTGGGTACCCAATGTCAAAGGTGAGTCCACTGTGTTTCGTGCACACACAGCC
ACAGTGAGGAGTGTCCACTTCTGCAGTGATGGCCAGTCCTTCGTGACAGCCTCTGACGACAAGACAGTCAAAGTGTGGGCAACTCATCGC
CAGAAATTCCTGTTCTCCCTGAGCCAGCATATCAACTGGGTCCGCTGTGCCAAGTTCTCCCCCGACGGGCGGCTCATCGTGTCTGCCAGT
GATGACAAGACTGTTAAGCTGTGGGACAAGAGCAGCCGGGAATGTGTCCACTCGTATTGTGAGCATGGCGGCTTTGTCACCTATGTGGAC
TTCCACCCCAGTGGGACGTGCATTGCCGCTGCCGGCATGGACAACACAGTGAAGGTGTGGGACGTGCGGACTCACCGGCTGCTGCAGCAT
TATCAGTTGCACAGTGCAGCAGTGAACGGGCTCTCTTTCCACCCGTCGGGAAACTACCTGATCACAGCCTCCAGTGACTCAACCCTGAAG
ATCCTGGACCTGATGGAGGGCCGGCTGCTCTACACACTCCACGGGCATCAGGGACCAGCCACCACTGTTGCCTTTTCAAGAACGGGGGAG
TATTTTGCTTCTGGAGGCTCTGATGAACAAGTGATGGTTTGGAAGAGTAACTTTGATATTGTTGATCATGGAGAAGTCACGAAAGTGCCG
AGGCCCCCAGCCACACTGGCCAGCTCCATGGGGAATCTGGTGAAGACAGAGATCAGTGTGGAAAGCAAGCACCAGACCCTGCAGGGCCTC
GCCTTCCCCCTGCAGCCTGAGGCCCAGCGGGCACTCCAGCAGCTCAAGCAGAAAATGGTCAACTACATCCAGATGAAGCTGGACCTAGAG
CGGGAAACCATTGAGCTGGTGCACACAGAGCCCACGGATGTGGCCCAGCTGCCCTCCCGGGTGCCCCGAGATGCTGCCCGCTACCACTTC
TTCCTCTACAAGCACACCCATGAGGGCGACCCCCTTGAGTCTGTAGATTGAGATTGGCGATGGGGCAGAGCTGACGGCAGAGTTCCTCTA
CGACGAGGTGCACCCCAAGCAACACGCCTTCAAGCAGGCCTTCGCCAAGCCCAAGGGCCCAGGGGGCAAGCGGGGCCATAAGCGCCTCAT
CCGCGGCCCGGGTGAAAATGGGGATGACAGCTAGGAGGCTGGAGCAGGGCCGGCCACGTGTGGACTGTGGGGCTGCCCACCTTCCGCTCC
CTGCCACCATCCTCCTTCCTGGGCTCCAGGAAAGTGTTTCTGGGAGGTCAGGAGGGCTGGCAGCTGAACGCACTTGCAGCGTCCGAGGGC
CACCGGGCTGGCATTTTGTGACCCTTCCCTGTTGCTGTCCCTGCATCTCGTCTGTGTGCCCAGGGTGTCCGGGGACCCTGCCTGGCTGGC
TTAAGGGGGCTGGGTCAGGGGCCTGGCATGAACCTGGCCTCCCGGGGAGCTGAGACTAGGGTCCCAGCACAGCCCAGAAACCTTTGGCCA

>66813_66813_4_POC1A-TWF2_POC1A_chr3_52156395_ENST00000394970_TWF2_chr3_52265011_ENST00000499914_length(amino acids)=501AA_BP=408
MAALSVGCLGLGNWARRPWRRPPVIQLCFQSSGKKLRRFSFNCGGRGVPTRPALLLVAVGGAETERAATATAAAFGAASPAMAAPCAEDP
SLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF
RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGF
VTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAF
SRTGEYFASGGSDEQVMVWKSNFDIVDHGEVTKVPRPPATLASSMGNLVKTEISVESKHQTLQGLAFPLQPEAQRALQQLKQKMVNYIQM

--------------------------------------------------------------

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Fusion Gene PPI Analysis for POC1A-TWF2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for POC1A-TWF2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for POC1A-TWF2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource