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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:POC1B-DUSP6 (FusionGDB2 ID:66815)

Fusion Gene Summary for POC1B-DUSP6

Fusion gene summary

Fusion gene information	Fusion gene name: POC1B-DUSP6
	Fusion gene ID: 66815
		Hgene	Tgene
	Gene symbol	POC1B	DUSP6
	Gene ID	282809	1848
	Gene name	POC1 centriolar protein B	dual specificity phosphatase 6
	Synonyms	CORD20\|PIX1\|TUWD12\|WDR51B	HH19\|MKP3\|PYST1
	Cytomap	12q21.33	12q21.33
	Type of gene	protein-coding	protein-coding
	Description	POC1 centriolar protein homolog BWD repeat-containing protein 51Bproteome of centriole protein 1B	dual specificity protein phosphatase 6MAP kinase phosphatase 3dual specificity protein phosphatase PYST1mitogen-activated protein kinase phosphatase 3serine/threonine specific protein phosphatase
	Modification date	20200313	20200327
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000378528, ENST00000549504, ENST00000313546, ENST00000393179, ENST00000541909, ENST00000549035, ENST00000546740,	ENST00000279488, ENST00000308385, ENST00000547291, ENST00000547140,
Fusion gene scores	* DoF score	5 X 4 X 5=100	2 X 2 X 2=8
	# samples	5	2
	** MAII score	log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/8*10)=1.32192809488736
Context	PubMed: POC1B [Title/Abstract] AND DUSP6 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	POC1B(89860547)-DUSP6(89743338), # samples:2
Anticipated loss of major functional domain due to fusion event.	POC1B-DUSP6 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. POC1B-DUSP6 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. POC1B-DUSP6 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	DUSP6	GO:0000188	inactivation of MAPK activity	8670865
Tgene	DUSP6	GO:0035335	peptidyl-tyrosine dephosphorylation	8670865
Tgene	DUSP6	GO:0043065	positive regulation of apoptotic process	10846176

Fusion gene breakpoints across POC1B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across DUSP6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	Non-Cancer	TCGA-06-0678-11A	POC1B	chr12	89860547	-	DUSP6	chr12	89743338	-
ChimerDB4	Non-Cancer	TCGA-E9-A1N4-11A	POC1B	chr12	89860547	-	DUSP6	chr12	89743338	-

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Fusion Gene ORF analysis for POC1B-DUSP6

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000378528	ENST00000279488	POC1B	chr12	89860547	-	DUSP6	chr12	89743338	-
3UTR-3CDS	ENST00000378528	ENST00000308385	POC1B	chr12	89860547	-	DUSP6	chr12	89743338	-
3UTR-3CDS	ENST00000378528	ENST00000547291	POC1B	chr12	89860547	-	DUSP6	chr12	89743338	-
3UTR-3CDS	ENST00000549504	ENST00000279488	POC1B	chr12	89860547	-	DUSP6	chr12	89743338	-
3UTR-3CDS	ENST00000549504	ENST00000308385	POC1B	chr12	89860547	-	DUSP6	chr12	89743338	-
3UTR-3CDS	ENST00000549504	ENST00000547291	POC1B	chr12	89860547	-	DUSP6	chr12	89743338	-
3UTR-5UTR	ENST00000378528	ENST00000547140	POC1B	chr12	89860547	-	DUSP6	chr12	89743338	-
3UTR-5UTR	ENST00000549504	ENST00000547140	POC1B	chr12	89860547	-	DUSP6	chr12	89743338	-
5CDS-5UTR	ENST00000313546	ENST00000547140	POC1B	chr12	89860547	-	DUSP6	chr12	89743338	-
5CDS-5UTR	ENST00000393179	ENST00000547140	POC1B	chr12	89860547	-	DUSP6	chr12	89743338	-
5CDS-5UTR	ENST00000541909	ENST00000547140	POC1B	chr12	89860547	-	DUSP6	chr12	89743338	-
5CDS-5UTR	ENST00000549035	ENST00000547140	POC1B	chr12	89860547	-	DUSP6	chr12	89743338	-
Frame-shift	ENST00000313546	ENST00000279488	POC1B	chr12	89860547	-	DUSP6	chr12	89743338	-
Frame-shift	ENST00000313546	ENST00000308385	POC1B	chr12	89860547	-	DUSP6	chr12	89743338	-
Frame-shift	ENST00000313546	ENST00000547291	POC1B	chr12	89860547	-	DUSP6	chr12	89743338	-
Frame-shift	ENST00000393179	ENST00000308385	POC1B	chr12	89860547	-	DUSP6	chr12	89743338	-
Frame-shift	ENST00000541909	ENST00000279488	POC1B	chr12	89860547	-	DUSP6	chr12	89743338	-
Frame-shift	ENST00000541909	ENST00000547291	POC1B	chr12	89860547	-	DUSP6	chr12	89743338	-
Frame-shift	ENST00000549035	ENST00000279488	POC1B	chr12	89860547	-	DUSP6	chr12	89743338	-
Frame-shift	ENST00000549035	ENST00000308385	POC1B	chr12	89860547	-	DUSP6	chr12	89743338	-
Frame-shift	ENST00000549035	ENST00000547291	POC1B	chr12	89860547	-	DUSP6	chr12	89743338	-
In-frame	ENST00000393179	ENST00000279488	POC1B	chr12	89860547	-	DUSP6	chr12	89743338	-
In-frame	ENST00000393179	ENST00000547291	POC1B	chr12	89860547	-	DUSP6	chr12	89743338	-
In-frame	ENST00000541909	ENST00000308385	POC1B	chr12	89860547	-	DUSP6	chr12	89743338	-
intron-3CDS	ENST00000546740	ENST00000279488	POC1B	chr12	89860547	-	DUSP6	chr12	89743338	-
intron-3CDS	ENST00000546740	ENST00000308385	POC1B	chr12	89860547	-	DUSP6	chr12	89743338	-
intron-3CDS	ENST00000546740	ENST00000547291	POC1B	chr12	89860547	-	DUSP6	chr12	89743338	-
intron-5UTR	ENST00000546740	ENST00000547140	POC1B	chr12	89860547	-	DUSP6	chr12	89743338	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000393179	POC1B	chr12	89860547	-	ENST00000279488	DUSP6	chr12	89743338	-	3586	1256	614	1327	237
ENST00000393179	POC1B	chr12	89860547	-	ENST00000547291	DUSP6	chr12	89743338	-	1746	1256	614	1327	237
ENST00000541909	POC1B	chr12	89860547	-	ENST00000308385	DUSP6	chr12	89743338	-	2158	965	323	1036	237

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000393179	ENST00000279488	POC1B	chr12	89860547	-	DUSP6	chr12	89743338	-	0.006750039	0.99325
ENST00000393179	ENST00000547291	POC1B	chr12	89860547	-	DUSP6	chr12	89743338	-	0.017928364	0.9820716
ENST00000541909	ENST00000308385	POC1B	chr12	89860547	-	DUSP6	chr12	89743338	-	0.008028363	0.9919716

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Fusion Genomic Features for POC1B-DUSP6

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for POC1B-DUSP6

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:89860547/chr12:89743338)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

POC1B

chr12:89860547

chr12:89743338

ENST00000313546

101_139

344

479.0

Repeat

Note=WD 3

Hgene

POC1B

chr12:89860547

chr12:89743338

ENST00000313546

142_181

344

479.0

Repeat

Note=WD 4

Hgene

POC1B

chr12:89860547

chr12:89743338

ENST00000313546

16_55

344

479.0

Repeat

Note=WD 1

Hgene

POC1B

chr12:89860547

chr12:89743338

ENST00000313546

183_223

344

479.0

Repeat

Note=WD 5

Hgene

POC1B

chr12:89860547

chr12:89743338

ENST00000313546

226_265

344

479.0

Repeat

Note=WD 6

Hgene

POC1B

chr12:89860547

chr12:89743338

ENST00000313546

268_307

344

479.0

Repeat

Note=WD 7

Hgene

POC1B

chr12:89860547

chr12:89743338

ENST00000313546

58_99

344

479.0

Repeat

Note=WD 2

Hgene

POC1B

chr12:89860547

chr12:89743338

ENST00000549035

101_139

302

437.0

Repeat

Note=WD 3

Hgene

POC1B

chr12:89860547

chr12:89743338

ENST00000549035

142_181

302

437.0

Repeat

Note=WD 4

Hgene

POC1B

chr12:89860547

chr12:89743338

ENST00000549035

16_55

302

437.0

Repeat

Note=WD 1

Hgene

POC1B

chr12:89860547

chr12:89743338

ENST00000549035

183_223

302

437.0

Repeat

Note=WD 5

Hgene

POC1B

chr12:89860547

chr12:89743338

ENST00000549035

226_265

302

437.0

Repeat

Note=WD 6

Hgene

POC1B

chr12:89860547

chr12:89743338

ENST00000549035

58_99

302

437.0

Repeat

Note=WD 2

Tgene

DUSP6

chr12:89860547

chr12:89743338

ENST00000308385

206_349

133

236.0

Domain

Tyrosine-protein phosphatase

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

POC1B

chr12:89860547

chr12:89743338

ENST00000313546

431_470

344

479.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

POC1B

chr12:89860547

chr12:89743338

ENST00000549035

431_470

302

437.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

POC1B

chr12:89860547

chr12:89743338

ENST00000313546

370_375

344

479.0

Compositional bias

Note=Poly-Thr

Hgene

POC1B

chr12:89860547

chr12:89743338

ENST00000549035

370_375

302

437.0

Compositional bias

Note=Poly-Thr

Hgene

POC1B

chr12:89860547

chr12:89743338

ENST00000549035

268_307

302

437.0

Repeat

Note=WD 7

Tgene

DUSP6

chr12:89860547

chr12:89743338

ENST00000279488

206_349

279

382.0

Domain

Tyrosine-protein phosphatase

Tgene

DUSP6

chr12:89860547

chr12:89743338

ENST00000279488

30_148

279

382.0

Domain

Rhodanese

Tgene

DUSP6

chr12:89860547

chr12:89743338

ENST00000308385

30_148

133

236.0

Domain

Rhodanese

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Fusion Gene Sequence for POC1B-DUSP6

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>66815_66815_1_POC1B-DUSP6_POC1B_chr12_89860547_ENST00000393179_DUSP6_chr12_89743338_ENST00000279488_length(transcript)=3586nt_BP=1256nt
TCTCGGAGGGTTTCCGTGGAGCGCCTGCGTCAGAATCACCTAGGAAGTATTAAAAAAAAAAAAAGTACCAAAGCCGAGGCGCATCCTCGC
ACCTGCCTGCCTTGGGCCAGCGGGCGGGGCCCGGGAACGTGCATTTCAAAGGGGCCGCGGTTCCTGCGATGCGCTGGACTCTGGGAAGCG
CGAACAGAGCGTTTTGCGGGCTCTGCGGGGAGAGCTGGCGCCGGCGTCTCCCTGTAGCAGGACTGGGCGCCGCGCCCGTGGGTGGGCTGC
TGCCCGGCCCCGCCGCCCAGCCAAGCCGCCGCCTGGGTGGCCATTCCCAAGCCGGACTCCGGGGAAGTGGCAGCGTGGATCCCAGCCGCC
AGAATTCGAGGTCTGCGGCGGCTTTCAAAACTTGACAACTTTCCTTTCCAGGAGGACCCCGTTCTGGAGCGTTATTTCAAAGGCCACAAA
GCTGCGATCACCTCCTTGGACCTCAGCCCCAACGGCAAGCAACTTGGAGAGGAAAATTCTCAGAATTTAAAGCTCATACAGCTCCAGTTC
GAAGTGTAGACTTTTCAGCTGATGGCCAGTTTCTAGCTACAGCTTCTGAAGACAAATCCATAAAAGTATGGAGCATGTATCGCCAGCGCT
TCCTGTATTCCTTGTATCGACATACACACTGGGTACGCTGTGCCAAATTTTCACCCGATGGAAGACTAATTGTGTCATGTAGTGAGGATA
AAACTATTAAAATTTGGGATACCACAAATAAGCAATGTGTTAATAACTTCTCAGATTCCGTTGGATTTGCAAATTTTGTGGACTTTAACC
CTAGTGGTACATGCATAGCTTCAGCAGGTTCTGATCAAACTGTGAAAGTCTGGGATGTAAGAGTGAACAAATTACTACAGCATTACCAAG
TTCACAGCGGTGGAGTTAATTGCATATCATTCCATCCTTCGGGTAACTATCTCATCACAGCTTCTTCAGATGGTACCCTTAAGATTCTGG
ACCTCTTAGAAGGAAGGCTCATCTATACACTTCAAGGACATACGGGACCTGTCTTTACTGTTTCATTTTCAAAAGGTGGAGAGCTATTTG
CATCAGGAGGTGCAGACACACAGGTCTTATTATGGAGGACTAACTTTGATGAATTGCATTGTAAAGGTCTTACCAAAAGAAATCTCAAAA
GATTACATTTTGATTCACCACCACATCTTCTTGATATCTACCCAAGAACACCACATCCCCATGAGGAAAAAGTTGAGACTGTAGAAATGA
AGCCCGGGGCAAGAACTGTGGTGTCTTGGTACATTGCTTGGCTGGCATTAGCCGCTCAGTCACTGTGACTGTGGCTTACCTTATGCAGAA
GCTCAATCTGTCGATGAACGACGCCTATGACATTGTCAAAATGAAAAAATCCAACATATCCCCTAACTTCAACTTCATGGGTCAGCTGCT
GGACTTCGAGAGGACGCTGGGACTCAGCAGCCCATGTGACAACAGGGTTCCAGCACAGCAGCTGTATTTTACCACCCCTTCCAACCAGAA
TGTATACCAGGTGGACTCTCTGCAATCTACGTGAAAGACCCCACACCCCTCCTTGCTGGAATGTGTCTGGCCCTTCAGCAGTTTCTCTTG
GCAGCATCAGCTGGGCTGCTTTCTTTGTGTGTGGCCCCAGGTGTCAAAATGACACCAGCTGTCTGTACTAGACAAGGTTACCAAGTGCGG
AATTGGTTAATACTAACAGAGAGATTTGCTCCATTCTCTTTGGAATAACAGGACATGCTGTATAGATACAGGCAGTAGGTTTGCTCTGTA
CCCATGTGTACAGCCTACCCATGCAGGGACTGGGATTCGAGGACTTCCAGGCGCATAGGGTAGAACCAAATGATAGGGTAGGAGCATGTG
TTCTTTAGGGCCTTGTAAGGCTGTTTCCTTTTGCATCTGGAACTGACTATATAATTGTCTTCAATGAAGACTAATTCAATTTTGCATATA
GAGGAGCCAAAGAGAGATTTCAGCTCTGTATTTGTGGTATCAGTTTGGAAAAAAAAATCTGATACTCCATTTGATTATTGTAAATATTTG
ATCTTGAATCACTTGACAGTGTTTGTTTGAATTGTGTTTGTTTTTTCCTTTGATGGGCTTAAAAGAAATTATCCAAAGGGAGAAAGAGCA
GTATGCCACTTCTTAAAACAGAACAAAACAAAAAAAGAAAATTGTGCTCTTTTCTAATCCAAAGGGTATATTTGCAGCATGCTTGACTTT
ACCAATTCTGATGACATCTTTACGGACACTATTATCACTAAGACCTTGTTATGGCGAAGTCTTTAGTCTTTTTCATGTATTTTCCTCATG
ATTTTTTCTCTTTATGTAGTTTGACTATGCCTTACCTTTGTAAATATTTTTGCTTGTGTTGTCGCAAAGGGGATAATCTGGGAAAGACAC
CAAATCATGGGCTCACTTTAAAAAAAGAAAGAATAAAAAAACCTTCAGCTGTGCTAAACAGTATATTACCTCTGTATAAAATTCTTCAGG
GAGTGTCACCTCAAATGCAATACTTTGGGTTGGTTTCTTTCCTTTAAAAAAATTTGTATAAAACTGGAAGTGTGTGTGTGTGAGCATGGG
TACCCATTTGATAAGAGAAATGCATTTGATTGTGAAGAAGGGAGAGTTAAATTCTCCATTATGTTCGTGGTGTAAAGTTTAGAGCTGGAA
TTTATTATAAGAATGTAAAACCTTAAATTATTAATAAATAACTATTTTGGCTATTGAATGTGTGTTTTTAAAAACTCAGTTATACCTATG
TGTGAAGTGACACATTTTAGAACTTTTTCATTCAGGGATTGATTTTGACTTGTAGGCATAGTAGGGCAAGGTTCTTTTAAGCTTTTCCTA
GAACGTTTTTCAGCAGCAGTTTATGAAATTCATCGTTTGCCACGAATAAAGATGACATCCTAGAATGGACCGACTGTACCGTGTATATGA
ACAATACCTCTTATGAGTATAGTTCCGGCTTAAGATTTTAAAGCCCCTGAAGAAAAATGAACCTATAGAGCATAGCTTGCTGAGGAATAC
AATTTGGATATTAACCACAGAGAGGTGTAGCAGAATACCAAGATGACAGCCACATGTTAACCTCCTCCCTATCCTTCACTGTCAGGATCT
TCTGCTTTATAATGCTGAGATAATGCCAAAGAGGAAGTAGGGATAATTCTTTTTCCAGTCTGTTGTCATGGGCAATTCTACCTGCAGATA
TCCTAGTGTGAGAATGCTGAATCCAGAATGATGTCTCCACTTTTTCCCCTAGCATGCGCATGGCAAGGCATATCTAAGCTTCCTCACCGT
GTCAGGATATGGCTTTAGAATTTTACATTGGCACTTAGGAGGCAACTTTGTCATCCCTGTTGTAATGTGCTTTTTTGTTTAACTGGCTTG
GGATGTGGGTCAGAAACCCTTATTGAAACTTGTGGGGATTATTTTAGTTTCTTTTCAAGCTAAAGACTTTATATCTTGCCATTTTTCTTG

>66815_66815_1_POC1B-DUSP6_POC1B_chr12_89860547_ENST00000393179_DUSP6_chr12_89743338_ENST00000279488_length(amino acids)=237AA_BP=0
MYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKL
LQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTNFDELHCKGLT

--------------------------------------------------------------
>66815_66815_2_POC1B-DUSP6_POC1B_chr12_89860547_ENST00000393179_DUSP6_chr12_89743338_ENST00000547291_length(transcript)=1746nt_BP=1256nt
TCTCGGAGGGTTTCCGTGGAGCGCCTGCGTCAGAATCACCTAGGAAGTATTAAAAAAAAAAAAAGTACCAAAGCCGAGGCGCATCCTCGC
ACCTGCCTGCCTTGGGCCAGCGGGCGGGGCCCGGGAACGTGCATTTCAAAGGGGCCGCGGTTCCTGCGATGCGCTGGACTCTGGGAAGCG
CGAACAGAGCGTTTTGCGGGCTCTGCGGGGAGAGCTGGCGCCGGCGTCTCCCTGTAGCAGGACTGGGCGCCGCGCCCGTGGGTGGGCTGC
TGCCCGGCCCCGCCGCCCAGCCAAGCCGCCGCCTGGGTGGCCATTCCCAAGCCGGACTCCGGGGAAGTGGCAGCGTGGATCCCAGCCGCC
AGAATTCGAGGTCTGCGGCGGCTTTCAAAACTTGACAACTTTCCTTTCCAGGAGGACCCCGTTCTGGAGCGTTATTTCAAAGGCCACAAA
GCTGCGATCACCTCCTTGGACCTCAGCCCCAACGGCAAGCAACTTGGAGAGGAAAATTCTCAGAATTTAAAGCTCATACAGCTCCAGTTC
GAAGTGTAGACTTTTCAGCTGATGGCCAGTTTCTAGCTACAGCTTCTGAAGACAAATCCATAAAAGTATGGAGCATGTATCGCCAGCGCT
TCCTGTATTCCTTGTATCGACATACACACTGGGTACGCTGTGCCAAATTTTCACCCGATGGAAGACTAATTGTGTCATGTAGTGAGGATA
AAACTATTAAAATTTGGGATACCACAAATAAGCAATGTGTTAATAACTTCTCAGATTCCGTTGGATTTGCAAATTTTGTGGACTTTAACC
CTAGTGGTACATGCATAGCTTCAGCAGGTTCTGATCAAACTGTGAAAGTCTGGGATGTAAGAGTGAACAAATTACTACAGCATTACCAAG
TTCACAGCGGTGGAGTTAATTGCATATCATTCCATCCTTCGGGTAACTATCTCATCACAGCTTCTTCAGATGGTACCCTTAAGATTCTGG
ACCTCTTAGAAGGAAGGCTCATCTATACACTTCAAGGACATACGGGACCTGTCTTTACTGTTTCATTTTCAAAAGGTGGAGAGCTATTTG
CATCAGGAGGTGCAGACACACAGGTCTTATTATGGAGGACTAACTTTGATGAATTGCATTGTAAAGGTCTTACCAAAAGAAATCTCAAAA
GATTACATTTTGATTCACCACCACATCTTCTTGATATCTACCCAAGAACACCACATCCCCATGAGGAAAAAGTTGAGACTGTAGAAATGA
AGCCCGGGGCAAGAACTGTGGTGTCTTGGTACATTGCTTGGCTGGCATTAGCCGCTCAGTCACTGTGACTGTGGCTTACCTTATGCAGAA
GCTCAATCTGTCGATGAACGACGCCTATGACATTGTCAAAATGAAAAAATCCAACATATCCCCTAACTTCAACTTCATGGGTCAGCTGCT
GGACTTCGAGAGGACGCTGGGACTCAGCAGCCCATGTGACAACAGGGTTCCAGCACAGCAGCTGTATTTTACCACCCCTTCCAACCAGAA
TGTATACCAGGTGGACTCTCTGCAATCTACGTGAAAGACCCCACACCCCTCCTTGCTGGAATGTGTCTGGCCCTTCAGCAGTTTCTCTTG
GCAGCATCAGCTGGGCTGCTTTCTTTGTGTGTGGCCCCAGGTGTCAAAATGACACCAGCTGTCTGTACTAGACAAGGTTACCAAGTGCGG

>66815_66815_2_POC1B-DUSP6_POC1B_chr12_89860547_ENST00000393179_DUSP6_chr12_89743338_ENST00000547291_length(amino acids)=237AA_BP=0
MYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKL
LQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTNFDELHCKGLT

--------------------------------------------------------------
>66815_66815_3_POC1B-DUSP6_POC1B_chr12_89860547_ENST00000541909_DUSP6_chr12_89743338_ENST00000308385_length(transcript)=2158nt_BP=965nt
GCAGACGGTTCCGGGAGCCGCACGGTCCCCTCTCCTTCCCCATCCTCTCCCCTCCCCTCTCCGGGTTCCCCCACCCACAGGAGCCTTGGG
CCGACCACTCCCCCGATGGCCTCAGCCACGGAGGACCCCGTTCTGGAGCGTTATTTCAAAGGCCACAAAGCTGCGATCACCTCCTTGGAC
CTCAGCCCCAACGGCAAGCAACTTGGAGAGGAAAATTCTCAGAATTTAAAGCTCATACAGCTCCAGTTCGAAGTGTAGACTTTTCAGCTG
ATGGCCAGTTTCTAGCTACAGCTTCTGAAGACAAATCCATAAAAGTATGGAGCATGTATCGCCAGCGCTTCCTGTATTCCTTGTATCGAC
ATACACACTGGGTACGCTGTGCCAAATTTTCACCCGATGGAAGACTAATTGTGTCATGTAGTGAGGATAAAACTATTAAAATTTGGGATA
CCACAAATAAGCAATGTGTTAATAACTTCTCAGATTCCGTTGGATTTGCAAATTTTGTGGACTTTAACCCTAGTGGTACATGCATAGCTT
CAGCAGGTTCTGATCAAACTGTGAAAGTCTGGGATGTAAGAGTGAACAAATTACTACAGCATTACCAAGTTCACAGCGGTGGAGTTAATT
GCATATCATTCCATCCTTCGGGTAACTATCTCATCACAGCTTCTTCAGATGGTACCCTTAAGATTCTGGACCTCTTAGAAGGAAGGCTCA
TCTATACACTTCAAGGACATACGGGACCTGTCTTTACTGTTTCATTTTCAAAAGGTGGAGAGCTATTTGCATCAGGAGGTGCAGACACAC
AGGTCTTATTATGGAGGACTAACTTTGATGAATTGCATTGTAAAGGTCTTACCAAAAGAAATCTCAAAAGATTACATTTTGATTCACCAC
CACATCTTCTTGATATCTACCCAAGAACACCACATCCCCATGAGGAAAAAGTTGAGACTGTAGAAATGAAGCCCGGGGCAAGAACTGTGG
TGTCTTGGTACATTGCTTGGCTGGCATTAGCCGCTCAGTCACTGTGACTGTGGCTTACCTTATGCAGAAGCTCAATCTGTCGATGAACGA
CGCCTATGACATTGTCAAAATGAAAAAATCCAACATATCCCCTAACTTCAACTTCATGGGTCAGCTGCTGGACTTCGAGAGGACGCTGGG
ACTCAGCAGCCCATGTGACAACAGGGTTCCAGCACAGCAGCTGTATTTTACCACCCCTTCCAACCAGAATGTATACCAGGTGGACTCTCT
GCAATCTACGTGAAAGACCCCACACCCCTCCTTGCTGGAATGTGTCTGGCCCTTCAGCAGTTTCTCTTGGCAGCATCAGCTGGGCTGCTT
TCTTTGTGTGTGGCCCCAGGTGTCAAAATGACACCAGCTGTCTGTACTAGACAAGGTTACCAAGTGCGGAATTGGTTAATACTAACAGAG
AGATTTGCTCCATTCTCTTTGGAATAACAGGACATGCTGTATAGATACAGGCAGTAGGTTTGCTCTGTACCCATGTGTACAGCCTACCCA
TGCAGGGACTGGGATTCGAGGACTTCCAGGCGCATAGGGTAGAACCAAATGATAGGGTAGGAGCATGTGTTCTTTAGGGCCTTGTAAGGC
TGTTTCCTTTTGCATCTGGAACTGACTATATAATTGTCTTCAATGAAGACTAATTCAATTTTGCATATAGAGGAGCCAAAGAGAGATTTC
AGCTCTGTATTTGTGGTATCAGTTTGGAAAAAAAAATCTGATACTCCATTTGATTATTGTAAATATTTGATCTTGAATCACTTGACAGTG
TTTGTTTGAATTGTGTTTGTTTTTTCCTTTGATGGGCTTAAAAGAAATTATCCAAAGGGAGAAAGAGCAGTATGCCACTTCTTAAAACAG
AACAAAACAAAAAAAGAAAATTGTGCTCTTTTCTAATCCAAAGGGTATATTTGCAGCATGCTTGACTTTACCAATTCTGATGACATCTTT
ACGGACACTATTATCACTAAGACCTTGTTATGGCGAAGTCTTTAGTCTTTTTCATGTATTTTCCTCATGATTTTTTCTCTTTATGTAGTT

>66815_66815_3_POC1B-DUSP6_POC1B_chr12_89860547_ENST00000541909_DUSP6_chr12_89743338_ENST00000308385_length(amino acids)=237AA_BP=0
MYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKL
LQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTNFDELHCKGLT

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for POC1B-DUSP6

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for POC1B-DUSP6

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for POC1B-DUSP6

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source