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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:PODXL-CREM (FusionGDB2 ID:66825)

Fusion Gene Summary for PODXL-CREM

Fusion gene summary

Fusion gene information	Fusion gene name: PODXL-CREM
	Fusion gene ID: 66825
		Hgene	Tgene
	Gene symbol	PODXL	CREM
	Gene ID	5420	1390
	Gene name	podocalyxin like	cAMP responsive element modulator
	Synonyms	Gp200\|PC\|PCLP\|PCLP-1	CREM-2\|ICER\|hCREM-2
	Cytomap	7q32.3	10p11.21
	Type of gene	protein-coding	protein-coding
	Description	podocalyxinGCTM-2 antigenpodocalyxin-like protein 1	cAMP-responsive element modulatorCREM 2alpha-b proteinCREM 2beta-a proteincAMP response element modulatorinducible cAMP early repressor ICER
	Modification date	20200329	20200313
	UniProtAcc	.	Q03060
	Ensembl transtripts involved in fusion gene	ENST00000322985, ENST00000378555, ENST00000465001, ENST00000537928, ENST00000541194,	ENST00000374721, ENST00000474362, ENST00000333809, ENST00000337656, ENST00000342105, ENST00000344351, ENST00000345491, ENST00000348787, ENST00000354759, ENST00000356917, ENST00000361599, ENST00000374726, ENST00000374728, ENST00000374734, ENST00000395887, ENST00000395895, ENST00000429130, ENST00000439705, ENST00000460270, ENST00000463314, ENST00000463960, ENST00000468236, ENST00000469949, ENST00000473940, ENST00000474931, ENST00000479070, ENST00000484283, ENST00000487763, ENST00000488328, ENST00000488741, ENST00000489321, ENST00000489388, ENST00000490511,
Fusion gene scores	* DoF score	7 X 6 X 3=126	12 X 12 X 7=1008
	# samples	7	12
	** MAII score	log2(7/126*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(12/1008*10)=-3.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: PODXL [Title/Abstract] AND CREM [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	PODXL(131186996)-CREM(35495948), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PODXL	GO:0030335	positive regulation of cell migration	18456258
Hgene	PODXL	GO:0033634	positive regulation of cell-cell adhesion mediated by integrin	18456258
Tgene	CREM	GO:0006355	regulation of transcription, DNA-templated	8206879

Fusion gene breakpoints across PODXL (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CREM (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	CD653634	PODXL	chr7	131186996	-	CREM	chr10	35495948	-

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Fusion Gene ORF analysis for PODXL-CREM

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3CDS	ENST00000322985	ENST00000374721	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-3CDS	ENST00000322985	ENST00000474362	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-3CDS	ENST00000378555	ENST00000374721	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-3CDS	ENST00000378555	ENST00000474362	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-3CDS	ENST00000465001	ENST00000374721	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-3CDS	ENST00000465001	ENST00000474362	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-3CDS	ENST00000537928	ENST00000374721	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-3CDS	ENST00000537928	ENST00000474362	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-3CDS	ENST00000541194	ENST00000374721	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-3CDS	ENST00000541194	ENST00000474362	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000322985	ENST00000333809	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000322985	ENST00000337656	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000322985	ENST00000342105	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000322985	ENST00000344351	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000322985	ENST00000345491	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000322985	ENST00000348787	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000322985	ENST00000354759	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000322985	ENST00000356917	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000322985	ENST00000361599	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000322985	ENST00000374726	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000322985	ENST00000374728	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000322985	ENST00000374734	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000322985	ENST00000395887	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000322985	ENST00000395895	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000322985	ENST00000429130	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000322985	ENST00000439705	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000322985	ENST00000460270	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000322985	ENST00000463314	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000322985	ENST00000463960	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000322985	ENST00000468236	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000322985	ENST00000469949	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000322985	ENST00000473940	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000322985	ENST00000474931	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000322985	ENST00000479070	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000322985	ENST00000484283	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000322985	ENST00000487763	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000322985	ENST00000488328	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000322985	ENST00000488741	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000322985	ENST00000489321	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000322985	ENST00000489388	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000322985	ENST00000490511	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000378555	ENST00000333809	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000378555	ENST00000337656	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000378555	ENST00000342105	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000378555	ENST00000344351	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000378555	ENST00000345491	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000378555	ENST00000348787	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000378555	ENST00000354759	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000378555	ENST00000356917	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000378555	ENST00000361599	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000378555	ENST00000374726	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000378555	ENST00000374728	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000378555	ENST00000374734	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000378555	ENST00000395887	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000378555	ENST00000395895	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000378555	ENST00000429130	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000378555	ENST00000439705	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000378555	ENST00000460270	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000378555	ENST00000463314	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000378555	ENST00000463960	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000378555	ENST00000468236	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000378555	ENST00000469949	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000378555	ENST00000473940	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000378555	ENST00000474931	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000378555	ENST00000479070	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000378555	ENST00000484283	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000378555	ENST00000487763	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000378555	ENST00000488328	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000378555	ENST00000488741	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000378555	ENST00000489321	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000378555	ENST00000489388	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000378555	ENST00000490511	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000465001	ENST00000333809	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000465001	ENST00000337656	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000465001	ENST00000342105	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000465001	ENST00000344351	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000465001	ENST00000345491	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000465001	ENST00000348787	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000465001	ENST00000354759	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000465001	ENST00000356917	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000465001	ENST00000361599	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000465001	ENST00000374726	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000465001	ENST00000374728	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000465001	ENST00000374734	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000465001	ENST00000395887	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000465001	ENST00000395895	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000465001	ENST00000429130	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000465001	ENST00000439705	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000465001	ENST00000460270	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000465001	ENST00000463314	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000465001	ENST00000463960	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000465001	ENST00000468236	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000465001	ENST00000469949	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000465001	ENST00000473940	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000465001	ENST00000474931	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000465001	ENST00000479070	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000465001	ENST00000484283	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000465001	ENST00000487763	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000465001	ENST00000488328	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000465001	ENST00000488741	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000465001	ENST00000489321	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000465001	ENST00000489388	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000465001	ENST00000490511	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000537928	ENST00000333809	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000537928	ENST00000337656	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000537928	ENST00000342105	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000537928	ENST00000344351	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000537928	ENST00000345491	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000537928	ENST00000348787	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000537928	ENST00000354759	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000537928	ENST00000356917	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000537928	ENST00000361599	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000537928	ENST00000374726	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000537928	ENST00000374728	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000537928	ENST00000374734	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000537928	ENST00000395887	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000537928	ENST00000395895	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000537928	ENST00000429130	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000537928	ENST00000439705	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000537928	ENST00000460270	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000537928	ENST00000463314	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000537928	ENST00000463960	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000537928	ENST00000468236	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000537928	ENST00000469949	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000537928	ENST00000473940	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000537928	ENST00000474931	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000537928	ENST00000479070	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000537928	ENST00000484283	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000537928	ENST00000487763	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000537928	ENST00000488328	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000537928	ENST00000488741	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000537928	ENST00000489321	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000537928	ENST00000489388	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000537928	ENST00000490511	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000541194	ENST00000333809	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000541194	ENST00000337656	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000541194	ENST00000342105	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000541194	ENST00000344351	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000541194	ENST00000345491	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000541194	ENST00000348787	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000541194	ENST00000354759	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000541194	ENST00000356917	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000541194	ENST00000361599	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000541194	ENST00000374726	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000541194	ENST00000374728	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000541194	ENST00000374734	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000541194	ENST00000395887	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000541194	ENST00000395895	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000541194	ENST00000429130	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000541194	ENST00000439705	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000541194	ENST00000460270	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000541194	ENST00000463314	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000541194	ENST00000463960	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000541194	ENST00000468236	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000541194	ENST00000469949	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000541194	ENST00000473940	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000541194	ENST00000474931	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000541194	ENST00000479070	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000541194	ENST00000484283	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000541194	ENST00000487763	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000541194	ENST00000488328	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000541194	ENST00000488741	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000541194	ENST00000489321	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000541194	ENST00000489388	PODXL	chr7	131186996	-	CREM	chr10	35495948	-
intron-intron	ENST00000541194	ENST00000490511	PODXL	chr7	131186996	-	CREM	chr10	35495948	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for PODXL-CREM

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PODXL-CREM

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:131186996/:35495948)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	CREM Q03060
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation (PubMed:10373550). {ECO:0000269\|PubMed:10373550}.; FUNCTION: [Isoform 6]: May play a role in the regulation of the circadian clock: acts as a transcriptional repressor of the core circadian component PER1 by directly binding to cAMP response elements in its promoter. {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for PODXL-CREM

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for PODXL-CREM

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for PODXL-CREM

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for PODXL-CREM

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source