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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:POGZ-CD36 (FusionGDB2 ID:66850)

Fusion Gene Summary for POGZ-CD36

Fusion gene summary

Fusion gene information	Fusion gene name: POGZ-CD36
	Fusion gene ID: 66850
		Hgene	Tgene
	Gene symbol	POGZ	CD36
	Gene ID	23126	948
	Gene name	pogo transposable element derived with ZNF domain	CD36 molecule
	Synonyms	MRD37\|WHSUS\|ZNF280E\|ZNF635\|ZNF635m	BDPLT10\|CHDS7\|FAT\|GP3B\|GP4\|GPIV\|PASIV\|SCARB3
	Cytomap	1q21.3	7q21.11
	Type of gene	protein-coding	protein-coding
	Description	pogo transposable element with ZNF domainputative protein product of Nbla00003zinc finger protein 280Ezinc finger protein 635	platelet glycoprotein 4CD36 antigen (collagen type I receptor, thrombospondin receptor)CD36 molecule (thrombospondin receptor)GPIIIBPAS IVPAS-4 proteincluster determinant 36fatty acid translocaseglycoprotein IIIbleukocyte differentiation antigen
	Modification date	20200327	20200322
	UniProtAcc	.	P16671
	Ensembl transtripts involved in fusion gene	ENST00000271715, ENST00000361398, ENST00000368863, ENST00000392723, ENST00000409503, ENST00000491586, ENST00000531094, ENST00000540984,	ENST00000309881, ENST00000394788, ENST00000432207, ENST00000433696, ENST00000435819, ENST00000441109, ENST00000447544, ENST00000534394, ENST00000538969, ENST00000544133,
Fusion gene scores	* DoF score	15 X 13 X 8=1560	5 X 6 X 4=120
	# samples	16	6
	** MAII score	log2(16/1560*10)=-3.28540221886225 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: POGZ [Title/Abstract] AND CD36 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	POGZ(151423280)-CD36(80306322), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	CD36	GO:0001954	positive regulation of cell-matrix adhesion	17416590
Tgene	CD36	GO:0007263	nitric oxide mediated signal transduction	17416590
Tgene	CD36	GO:0019934	cGMP-mediated signaling	17416590
Tgene	CD36	GO:0044539	long-chain fatty acid import	17416590\|22022213
Tgene	CD36	GO:0071726	cellular response to diacyl bacterial lipopeptide	16880211

Fusion gene breakpoints across POGZ (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CD36 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	BM144437	POGZ	chr1	151423280	-	CD36	chr7	80306322	-

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Fusion Gene ORF analysis for POGZ-CD36

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000271715	ENST00000309881	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000271715	ENST00000394788	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000271715	ENST00000432207	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000271715	ENST00000433696	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000271715	ENST00000435819	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000271715	ENST00000441109	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000271715	ENST00000447544	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000271715	ENST00000534394	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000271715	ENST00000538969	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000271715	ENST00000544133	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000361398	ENST00000309881	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000361398	ENST00000394788	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000361398	ENST00000432207	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000361398	ENST00000433696	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000361398	ENST00000435819	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000361398	ENST00000441109	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000361398	ENST00000447544	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000361398	ENST00000534394	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000361398	ENST00000538969	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000361398	ENST00000544133	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000368863	ENST00000309881	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000368863	ENST00000394788	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000368863	ENST00000432207	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000368863	ENST00000433696	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000368863	ENST00000435819	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000368863	ENST00000441109	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000368863	ENST00000447544	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000368863	ENST00000534394	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000368863	ENST00000538969	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000368863	ENST00000544133	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000392723	ENST00000309881	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000392723	ENST00000394788	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000392723	ENST00000432207	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000392723	ENST00000433696	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000392723	ENST00000435819	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000392723	ENST00000441109	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000392723	ENST00000447544	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000392723	ENST00000534394	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000392723	ENST00000538969	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000392723	ENST00000544133	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000409503	ENST00000309881	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000409503	ENST00000394788	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000409503	ENST00000432207	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000409503	ENST00000433696	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000409503	ENST00000435819	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000409503	ENST00000441109	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000409503	ENST00000447544	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000409503	ENST00000534394	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000409503	ENST00000538969	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000409503	ENST00000544133	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000491586	ENST00000309881	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000491586	ENST00000394788	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000491586	ENST00000432207	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000491586	ENST00000433696	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000491586	ENST00000435819	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000491586	ENST00000441109	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000491586	ENST00000447544	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000491586	ENST00000534394	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000491586	ENST00000538969	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000491586	ENST00000544133	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000531094	ENST00000309881	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000531094	ENST00000394788	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000531094	ENST00000432207	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000531094	ENST00000433696	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000531094	ENST00000435819	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000531094	ENST00000441109	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000531094	ENST00000447544	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000531094	ENST00000534394	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000531094	ENST00000538969	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000531094	ENST00000544133	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000540984	ENST00000309881	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000540984	ENST00000394788	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000540984	ENST00000432207	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000540984	ENST00000433696	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000540984	ENST00000435819	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000540984	ENST00000441109	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000540984	ENST00000447544	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000540984	ENST00000534394	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000540984	ENST00000538969	POGZ	chr1	151423280	-	CD36	chr7	80306322	-
intron-intron	ENST00000540984	ENST00000544133	POGZ	chr1	151423280	-	CD36	chr7	80306322	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for POGZ-CD36

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for POGZ-CD36

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:151423280/:80306322)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	CD36 P16671
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Multifunctional glycoprotein that acts as receptor for a broad range of ligands. Ligands can be of proteinaceous nature like thrombospondin, fibronectin, collagen or amyloid-beta as well as of lipidic nature such as oxidized low-density lipoprotein (oxLDL), anionic phospholipids, long-chain fatty acids and bacterial diacylated lipopeptides. They are generally multivalent and can therefore engage multiple receptors simultaneously, the resulting formation of CD36 clusters initiates signal transduction and internalization of receptor-ligand complexes. The dependency on coreceptor signaling is strongly ligand specific. Cellular responses to these ligands are involved in angiogenesis, inflammatory response, fatty acid metabolism, taste and dietary fat processing in the intestine (Probable). Binds long-chain fatty acids and facilitates their transport into cells, thus participating in muscle lipid utilization, adipose energy storage, and gut fat absorption (By similarity) (PubMed:18353783, PubMed:21610069). In the small intestine, plays a role in proximal absorption of dietary fatty acid and cholesterol for optimal chylomicron formation, possibly through the activation of MAPK1/3 (ERK1/2) signaling pathway (By similarity) (PubMed:18753675). Involved in oral fat perception and preferences (PubMed:22240721, PubMed:25822988). Detection into the tongue of long-chain fatty acids leads to a rapid and sustained rise in flux and protein content of pancreatobiliary secretions (By similarity). In taste receptor cells, mediates the induction of an increase in intracellular calcium levels by long-chain fatty acids, leading to the activation of the gustatory neurons in the nucleus of the solitary tract (By similarity). Important factor in both ventromedial hypothalamus neuronal sensing of long-chain fatty acid and the regulation of energy and glucose homeostasis (By similarity). Receptor for thombospondins, THBS1 and THBS2, mediating their antiangiogenic effects (By similarity). As a coreceptor for TLR4:TLR6 heterodimer, promotes inflammation in monocytes/macrophages. Upon ligand binding, such as oxLDL or amyloid-beta 42, interacts with the heterodimer TLR4:TLR6, the complex is internalized and triggers inflammatory response, leading to NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion, through the priming and activation of the NLRP3 inflammasome (By similarity) (PubMed:20037584). Selective and nonredundant sensor of microbial diacylated lipopeptide that signal via TLR2:TLR6 heterodimer, this cluster triggers signaling from the cell surface, leading to the NF-kappa-B-dependent production of TNF, via MYD88 signaling pathway and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (By similarity) (PubMed:16880211). {ECO:0000250\|UniProtKB:Q07969, ECO:0000250\|UniProtKB:Q08857, ECO:0000269\|PubMed:16880211, ECO:0000269\|PubMed:18353783, ECO:0000269\|PubMed:18753675, ECO:0000269\|PubMed:20037584, ECO:0000269\|PubMed:21395585, ECO:0000269\|PubMed:21610069, ECO:0000269\|PubMed:22240721, ECO:0000269\|PubMed:25822988, ECO:0000305\|PubMed:19471024}.; FUNCTION: (Microbial infection) Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and the internalization of particles independently of TLR signaling. {ECO:0000269\|PubMed:10890433, ECO:0000269\|PubMed:12506336, ECO:0000269\|PubMed:19864601}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for POGZ-CD36

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for POGZ-CD36

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for POGZ-CD36

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for POGZ-CD36

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source