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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:POLA2-PPFIA1 (FusionGDB2 ID:66884)

Fusion Gene Summary for POLA2-PPFIA1

check button Fusion gene summary
Fusion gene informationFusion gene name: POLA2-PPFIA1
Fusion gene ID: 66884
HgeneTgene
Gene symbol

POLA2

PPFIA1

Gene ID

23649

8500

Gene nameDNA polymerase alpha 2, accessory subunitPTPRF interacting protein alpha 1
Synonyms-LIP.1|LIP1|LIPRIN
Cytomap

11q13.1

11q13.3

Type of geneprotein-codingprotein-coding
DescriptionDNA polymerase alpha subunit BDNA polymerase alpha 70 kDa subunitpolymerase (DNA directed), alpha 2 (70kD subunit)polymerase (DNA directed), alpha 2, accessory subunitpolymerase (DNA) alpha 2, accessory subunitpolymerase (DNA-directed), alpha (70kD)liprin-alpha-1LAR-interacting protein 1LIP-1Liprin-alpha1protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
Modification date2020031320200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000265465, ENST00000541089, 
ENST00000534785, 		ENST00000530548, 
ENST00000253925, ENST00000389547, 
Fusion gene scores* DoF score6 X 7 X 5=21019 X 19 X 10=3610
# samples 724
** MAII scorelog2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(24/3610*10)=-3.91089252616601
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: POLA2 [Title/Abstract] AND PPFIA1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPOLA2(65047097)-PPFIA1(70200407), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across POLA2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PPFIA1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-C8-A1HK-01APOLA2chr11

65047097

-PPFIA1chr11

70200407

+
ChimerDB4BRCATCGA-C8-A1HK-01APOLA2chr11

65047097

+PPFIA1chr11

70200407

+


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Fusion Gene ORF analysis for POLA2-PPFIA1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000265465ENST00000530548POLA2chr11

65047097

+PPFIA1chr11

70200407

+
5CDS-intronENST00000541089ENST00000530548POLA2chr11

65047097

+PPFIA1chr11

70200407

+
In-frameENST00000265465ENST00000253925POLA2chr11

65047097

+PPFIA1chr11

70200407

+
In-frameENST00000265465ENST00000389547POLA2chr11

65047097

+PPFIA1chr11

70200407

+
In-frameENST00000541089ENST00000253925POLA2chr11

65047097

+PPFIA1chr11

70200407

+
In-frameENST00000541089ENST00000389547POLA2chr11

65047097

+PPFIA1chr11

70200407

+
intron-3CDSENST00000534785ENST00000253925POLA2chr11

65047097

+PPFIA1chr11

70200407

+
intron-3CDSENST00000534785ENST00000389547POLA2chr11

65047097

+PPFIA1chr11

70200407

+
intron-intronENST00000534785ENST00000530548POLA2chr11

65047097

+PPFIA1chr11

70200407

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000265465POLA2chr1165047097+ENST00000253925PPFIA1chr1170200407+413112754922720742
ENST00000265465POLA2chr1165047097+ENST00000389547PPFIA1chr1170200407+304712754922669725
ENST00000541089POLA2chr1165047097+ENST00000253925PPFIA1chr1170200407+38069504012395664
ENST00000541089POLA2chr1165047097+ENST00000389547PPFIA1chr1170200407+27229504012344647

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000265465ENST00000253925POLA2chr1165047097+PPFIA1chr1170200407+0.0012785660.9987214
ENST00000265465ENST00000389547POLA2chr1165047097+PPFIA1chr1170200407+0.0022918370.9977082
ENST00000541089ENST00000253925POLA2chr1165047097+PPFIA1chr1170200407+0.002157510.99784243
ENST00000541089ENST00000389547POLA2chr1165047097+PPFIA1chr1170200407+0.0040441080.9959559

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Fusion Genomic Features for POLA2-PPFIA1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
POLA2chr1165047097+PPFIA1chr1170200406+1.93E-070.99999976
POLA2chr1165047097+PPFIA1chr1170200406+1.93E-070.99999976

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for POLA2-PPFIA1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:65047097/chr11:70200407)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePOLA2chr11:65047097chr11:70200407ENST00000265465+718101_107248599.0Compositional biasNote=Poly-Glu
HgenePOLA2chr11:65047097chr11:70200407ENST00000265465+718115_157248599.0Compositional biasNote=Pro/Ser/Thr-rich
TgenePPFIA1chr11:65047097chr11:70200407ENST0000025392515281021_10507211597.3333333333333Coiled coilOntology_term=ECO:0000255
TgenePPFIA1chr11:65047097chr11:70200407ENST000002539251528847_8717211597.3333333333333Coiled coilOntology_term=ECO:0000255
TgenePPFIA1chr11:65047097chr11:70200407ENST0000038954715261021_10507211186.0Coiled coilOntology_term=ECO:0000255
TgenePPFIA1chr11:65047097chr11:70200407ENST000003895471526847_8717211186.0Coiled coilOntology_term=ECO:0000255
TgenePPFIA1chr11:65047097chr11:70200407ENST0000025392515281051_11207211597.3333333333333DomainSAM 3
TgenePPFIA1chr11:65047097chr11:70200407ENST000002539251528878_9447211597.3333333333333DomainSAM 1
TgenePPFIA1chr11:65047097chr11:70200407ENST000002539251528963_10277211597.3333333333333DomainSAM 2
TgenePPFIA1chr11:65047097chr11:70200407ENST0000038954715261051_11207211186.0DomainSAM 3
TgenePPFIA1chr11:65047097chr11:70200407ENST000003895471526878_9447211186.0DomainSAM 1
TgenePPFIA1chr11:65047097chr11:70200407ENST000003895471526963_10277211186.0DomainSAM 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePOLA2chr11:65047097chr11:70200407ENST00000265465+718486_489248599.0Compositional biasNote=Poly-Ser
TgenePPFIA1chr11:65047097chr11:70200407ENST000002539251528176_2147211597.3333333333333Coiled coilOntology_term=ECO:0000255
TgenePPFIA1chr11:65047097chr11:70200407ENST000002539251528249_5217211597.3333333333333Coiled coilOntology_term=ECO:0000255
TgenePPFIA1chr11:65047097chr11:70200407ENST00000253925152834_1417211597.3333333333333Coiled coilOntology_term=ECO:0000255
TgenePPFIA1chr11:65047097chr11:70200407ENST000002539251528623_6697211597.3333333333333Coiled coilOntology_term=ECO:0000255
TgenePPFIA1chr11:65047097chr11:70200407ENST000003895471526176_2147211186.0Coiled coilOntology_term=ECO:0000255
TgenePPFIA1chr11:65047097chr11:70200407ENST000003895471526249_5217211186.0Coiled coilOntology_term=ECO:0000255
TgenePPFIA1chr11:65047097chr11:70200407ENST00000389547152634_1417211186.0Coiled coilOntology_term=ECO:0000255
TgenePPFIA1chr11:65047097chr11:70200407ENST000003895471526623_6697211186.0Coiled coilOntology_term=ECO:0000255
TgenePPFIA1chr11:65047097chr11:70200407ENST00000253925152817_257211597.3333333333333Compositional biasNote=Poly-Gly
TgenePPFIA1chr11:65047097chr11:70200407ENST00000389547152617_257211186.0Compositional biasNote=Poly-Gly


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Fusion Gene Sequence for POLA2-PPFIA1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>66884_66884_1_POLA2-PPFIA1_POLA2_chr11_65047097_ENST00000265465_PPFIA1_chr11_70200407_ENST00000253925_length(transcript)=4131nt_BP=1275nt
GCAGCTGCTGACTGGCGGGCCGCCAGGCGCGTGCGTAGAGACGCCCACACGCCCGCTGATGCGCACGCGCCCTGGGCCGCGCGTGCGCGC
GTGGGGTTCCGGAATGAGCCGGGGAAAGCAAGGGGAAGGTTTGGGGTTGGCTCCCGGTTTCGCGCATGCGTGCACTGCACAAACCATTTG
GCGGGTTTTTCCGGCCACTCAGTTCTGCCACCGTCACTGAGAAGCTCAGCGGTAGCTTTTGGGAAGCAGGACGTTCTCACCAGGAGAGCG
TCCTCTCGAGATTTCTGCTCCCTCCATTCAGGGCGTTTGGGAGCCACCCCTTCATTTTTTAAAAAAAGTATTTCTCTGTGACCGACGGCC
GGGGCCTTCTGACGGTCTGAGGTCTTGCTTGGGCCAGTCACCTCCTGTCACGGTCCGCGGAGGGGGGAAGGATAAGAGGGCGAGGAGCTC
ATCGCTCGCCACCCCCGTGGGCTTCTTGGGCGCAGGTCGGAGCTGGGTGGGCCGGCTCCCCGGCCCCTGGCTTGGGCGACCATGTCCGCA
TCCGCCCAGCAGCTGGCGGAGGAGCTGCAGATCTTCGGCCTAGACTGCGAGGAGGCTCTAATTGAGAAATTGGTAGAGCTTTGTGTTCAG
TATGGACAGAATGAGGAGGGAATGGTAGGCGAGCTTATAGCCTTCTGCACCAGCACACATAAAGTTGGCCTTACCTCAGAGATCCTGAAC
TCTTTTGAGCATGAGTTTCTGAGCAAAAGATTATCGAAAGCCAGGCATAGTACCTGCAAGGACAGTGGCCATGCAGGAGCTAGAGACATT
GTTTCCATTCAAGAGCTAATTGAAGTGGAAGAAGAAGAGGAAATCCTCTTGAACTCTTACACCACACCTTCAAAGGGTTCTCAGAAGCGA
GCTATCTCTACCCCAGAAACCCCCCTAACAAAAAGGAGTGTGTCAACTCGTAGCCCCCATCAGCTACTCTCACCGTCAAGTTTCTCTCCA
AGTGCTACTCCCTCCCAGAAATACAACTCACGAAGTAACCGAGGAGAAGTGGTTACCTCCTTCGGCTTAGCACAGGGAGTATCTTGGTCT
GGGAGAGGAGGAGCTGGAAACATCAGCCTGAAGGTCTTGGGATGTCCAGAGGCACTAACTGGGAGCTACAAATCCATGTTTCAGAAGCTC
CCAGACATTCGAGAAGTTCTGACCTGTAAGATAGAAGAACTTGGCAGCGAACTCAAGGAACATTACAAGATTGAAGCTTTCACTCCTTTG
CTAGCCCCAGCACAGTTGCCACCTTCCAGAGAAGAGGTACGAGATGACAAGACAACCATAAAGTGTGAAACCTCCCCGCCTTCCTCCCCG
AGAGCCCTTCGGTTAGACCGGCTGCACAAAGGGGCGCTGCACACCGTCAGCCACGAGGACATCAGGGACATAAGGAACTCCACAGGCTCC
CAGGATGGTCCCGTGAGCAACCCCAGCAGTAGCAACAGTAGCCAGGACTCGCTCCACAAAGCCCCAAAGAAGAAAGGCATTAAGTCCTCC
ATTGGCCGCTTGTTTGGCAAGAAAGAAAAGGGCCGACCTGGACAAACTGGCAAAGAAGCATTAGGACAAGCTGGTGTTTCCGAGACGGAT
AACTCATCTCAGGATGCCTTGGGACTTAGCAAATTGGGGGGACAGGCTGAAAAAAATCGTAAACTTCAAAAAAAGCATGAATTGCTGGAG
GAAGCCCGGAGACAAGGTTTACCTTTTGCCCAATGGGACGGGCCAACGGTTGTGGTCTGGCTAGAGCTCTGGGTTGGGATGCCAGCCTGG
TATGTGGCTGCCTGCCGAGCAAACGTGAAAAGCGGGGCCATCATGTCGGCCCTGTCCGACACAGAGATCCAGCGTGAGATTGGCATCAGC
AACCCCCTGCACAGGCTGAAGCTGAGGCTGGCCATCCAGGAGATCATGTCGCTGACCAGCCCGTCTGCCCCGCCCACATCTAGAACGACA
CTCGCCTATGGGGACATGAACCACGAGTGGATCGGCAACGAGTGGCTCCCCAGCCTGGGCCTCCCCCAGTACCGCAGCTACTTCATGGAG
TGCCTTGTAGACGCCAGGATGCTGGACCACTTGACCAAGAAAGACCTTCGAGGGCAGCTGAAAATGGTCGACAGTTTTCACAGAAACAGT
TTCCAGTGTGGAATTATGTGCCTGAGAAGGTTAAATTATGACCGGAAAGAACTGGAAAGAAAAAGAGAAGAAAGTCAGAGTGAAATAAAA
GACGTGCTTGTTTGGAGCAATGATCGAGTGATTCGCTGGATCCTGTCAATTGGCCTTAAAGAATATGCAAACAATCTTATAGAGAGTGGT
GTTCACGGAGCACTTCTGGCCTTAGATGAAACCTTCGACTTCAGTGCACTGGCACTGCTGTTACAGATCCCGACGCAGAACACACAGGCT
CGTGCTGTCTTGGAAAGAGAATTTAACAACCTTTTGGTCATGGGGACTGATAGAAGGTTTGATGAAGATGATGATAAAAGCTTTAGGAGA
GCACCTTCATGGAGAAAAAAGTTTAGACCAAAGGACATTCGTGGCTTAGCTGCTGGGTCAGCAGAGACTCTCCCTGCAAACTTCCGGGTG
ACTTCTTCTATGTCTTCCCCCTCTATGCAGCCAAAGAAGATGCAGATGGACGGCAATGTATCAGGAACACAGAGGTTGGATTCTGCTACA
GTCAGGACTTACTCCTGCTAAAGTCTCCTGTTGTTTACCCACACTACTTCTACAGATGATTATGCAGCATTTGAATCCAACAAAGACTAC
ATTTTGGAATCCAGTGGAATCTTTAATCTTGTTAATACTTGTTATATGGACCCTAAGATATTTTATTACAGAGTTTTTAATTAGTGAAAA
ATTCATGAATACCATAGAGAAAATATTTTAGAATTTAATGTTTCTTATATTTATGTAAACTTATGACTCTTCATTTATATAGTTACTTAC
TTTTTCATGTATATCCAGGCTATAAATATCCTTTCAAATCATGTTCTTATACCTAATTTTAGTCTTTCAAATGAATGTACTGTAATGCTT
GTATGTATAAATCCTATGAATAGAGGGCTTTTGTAAATTATGCATTTATTGTAATTATCATTAATTTTTTAATGATAAACCATGACAAAG
GATTTTACGTTTATAAAATTATGACAGAAGCCATGTGCATTATCCTTTACGGACGCAGCCTAGCTCTACAGCAATCATCCTGAAATAAGC
ATACCTAATTTCAAGCAATTGTTGTATTTTCATGACTGACCTTAACTGTACTTTTTCTAGCAAGAGATGCTTTATTCTGCAGCATGAACA
GATTTAAAATGGCTGGTGTTAAATATCAGCTCCTAATAAGATGTGGACTGAAAACACTATCACAACACTATGAGAAGCCCCTAGCACTGG
TTAACGCTTTCCTAGCCTAGTCTCTGGATTTGGGGAGCTTGTCTTCAGTGGCTGAGACTGTGAGCTGGGAGCAGTTCTCTCAGCTGGAGA
GACTCGGGATGGGGTAACCTGGGGACCAGTCTAGCCCCTGCACCCTCTTCCCTGCCTCTGCTCCTTGGGAGCGGGTGGAGAGACACCCAT
GTGGCTCCCCTTAGGGCCAGCACCAAGCACCACGCTCTCATCCTGCAAGTCGGCGCACACAGTGGATGAAGGCAGGAGACCCAGAAAGCA
GTGCAGTGCAGCTCTAATAAAGGCCTTATTTTTCTTATGTAAATCATCTTTTTACATTTGTTTGTAAACATGTTTAAAGAACGAACCTAG
TGGGACATTTTTAGACTTTGATGCTCTAGCCATTTTGGATTGTGTAAGTTGCAGATGTGGCTTTTACTTTTTAAATGGCATATTAACAAG
CCAGCAAAGTGTGTCAGACCATGGCGTGGTATTTATTGTGCAGCAGATCCAGAGACAGAGGCAGCCTGTCTTTTCAGTTGGTTTCTGCTT
TTAATTTACTTGTACAATTCATTGTTACTGTTCTGTTTTTCTATTAATCTTTTGTCAACTTCCTGATTATGTAACAAAGTATGTACAGTC

>66884_66884_1_POLA2-PPFIA1_POLA2_chr11_65047097_ENST00000265465_PPFIA1_chr11_70200407_ENST00000253925_length(amino acids)=742AA_BP=1
MGGPAPRPLAWATMSASAQQLAEELQIFGLDCEEALIEKLVELCVQYGQNEEGMVGELIAFCTSTHKVGLTSEILNSFEHEFLSKRLSKA
RHSTCKDSGHAGARDIVSIQELIEVEEEEEILLNSYTTPSKGSQKRAISTPETPLTKRSVSTRSPHQLLSPSSFSPSATPSQKYNSRSNR
GEVVTSFGLAQGVSWSGRGGAGNISLKVLGCPEALTGSYKSMFQKLPDIREVLTCKIEELGSELKEHYKIEAFTPLLAPAQLPPSREEVR
DDKTTIKCETSPPSSPRALRLDRLHKGALHTVSHEDIRDIRNSTGSQDGPVSNPSSSNSSQDSLHKAPKKKGIKSSIGRLFGKKEKGRPG
QTGKEALGQAGVSETDNSSQDALGLSKLGGQAEKNRKLQKKHELLEEARRQGLPFAQWDGPTVVVWLELWVGMPAWYVAACRANVKSGAI
MSALSDTEIQREIGISNPLHRLKLRLAIQEIMSLTSPSAPPTSRTTLAYGDMNHEWIGNEWLPSLGLPQYRSYFMECLVDARMLDHLTKK
DLRGQLKMVDSFHRNSFQCGIMCLRRLNYDRKELERKREESQSEIKDVLVWSNDRVIRWILSIGLKEYANNLIESGVHGALLALDETFDF
SALALLLQIPTQNTQARAVLEREFNNLLVMGTDRRFDEDDDKSFRRAPSWRKKFRPKDIRGLAAGSAETLPANFRVTSSMSSPSMQPKKM

--------------------------------------------------------------
>66884_66884_2_POLA2-PPFIA1_POLA2_chr11_65047097_ENST00000265465_PPFIA1_chr11_70200407_ENST00000389547_length(transcript)=3047nt_BP=1275nt
GCAGCTGCTGACTGGCGGGCCGCCAGGCGCGTGCGTAGAGACGCCCACACGCCCGCTGATGCGCACGCGCCCTGGGCCGCGCGTGCGCGC
GTGGGGTTCCGGAATGAGCCGGGGAAAGCAAGGGGAAGGTTTGGGGTTGGCTCCCGGTTTCGCGCATGCGTGCACTGCACAAACCATTTG
GCGGGTTTTTCCGGCCACTCAGTTCTGCCACCGTCACTGAGAAGCTCAGCGGTAGCTTTTGGGAAGCAGGACGTTCTCACCAGGAGAGCG
TCCTCTCGAGATTTCTGCTCCCTCCATTCAGGGCGTTTGGGAGCCACCCCTTCATTTTTTAAAAAAAGTATTTCTCTGTGACCGACGGCC
GGGGCCTTCTGACGGTCTGAGGTCTTGCTTGGGCCAGTCACCTCCTGTCACGGTCCGCGGAGGGGGGAAGGATAAGAGGGCGAGGAGCTC
ATCGCTCGCCACCCCCGTGGGCTTCTTGGGCGCAGGTCGGAGCTGGGTGGGCCGGCTCCCCGGCCCCTGGCTTGGGCGACCATGTCCGCA
TCCGCCCAGCAGCTGGCGGAGGAGCTGCAGATCTTCGGCCTAGACTGCGAGGAGGCTCTAATTGAGAAATTGGTAGAGCTTTGTGTTCAG
TATGGACAGAATGAGGAGGGAATGGTAGGCGAGCTTATAGCCTTCTGCACCAGCACACATAAAGTTGGCCTTACCTCAGAGATCCTGAAC
TCTTTTGAGCATGAGTTTCTGAGCAAAAGATTATCGAAAGCCAGGCATAGTACCTGCAAGGACAGTGGCCATGCAGGAGCTAGAGACATT
GTTTCCATTCAAGAGCTAATTGAAGTGGAAGAAGAAGAGGAAATCCTCTTGAACTCTTACACCACACCTTCAAAGGGTTCTCAGAAGCGA
GCTATCTCTACCCCAGAAACCCCCCTAACAAAAAGGAGTGTGTCAACTCGTAGCCCCCATCAGCTACTCTCACCGTCAAGTTTCTCTCCA
AGTGCTACTCCCTCCCAGAAATACAACTCACGAAGTAACCGAGGAGAAGTGGTTACCTCCTTCGGCTTAGCACAGGGAGTATCTTGGTCT
GGGAGAGGAGGAGCTGGAAACATCAGCCTGAAGGTCTTGGGATGTCCAGAGGCACTAACTGGGAGCTACAAATCCATGTTTCAGAAGCTC
CCAGACATTCGAGAAGTTCTGACCTGTAAGATAGAAGAACTTGGCAGCGAACTCAAGGAACATTACAAGATTGAAGCTTTCACTCCTTTG
CTAGCCCCAGCACAGTTGCCACCTTCCAGAGAAGAGGTACGAGATGACAAGACAACCATAAAGTGTGAAACCTCCCCGCCTTCCTCCCCG
AGAGCCCTTCGGTTAGACCGGCTGCACAAAGGGGCGCTGCACACCGTCAGCCACGAGGACATCAGGGACATAAGGAACTCCACAGGCTCC
CAGGATGGTCCCGTGAGCAACCCCAGCAGTAGCAACAGTAGCCAGGACTCGCTCCACAAAGCCCCAAAGAAGAAAGGCATTAAGTCCTCC
ATTGGCCGCTTGTTTGGCAAGAAAGAAAAGGGCCGACCTGGACAAACTGGCAAAGAAGCATTAGGACAAGCTGGTGTTTCCGAGACGGAT
AACTCATCTCAGGATGCCTTGGGACTTAGCAAATTGGGGGGACAGGCTGAAAAAAATCGTAAACTTCAAAAAAAGCATGAATTGCTGGAG
GAAGCCCGGAGACAAGGTTTACCTTTTGCCCAATGGGACGGGCCAACGGTTGTGGTCTGGCTAGAGCTCTGGGTTGGGATGCCAGCCTGG
TATGTGGCTGCCTGCCGAGCAAACGTGAAAAGCGGGGCCATCATGTCGGCCCTGTCCGACACAGAGATCCAGCGTGAGATTGGCATCAGC
AACCCCCTGCACAGGCTGAAGCTGAGGCTGGCCATCCAGGAGATCATGTCGCTGACCAGCCCGTCTGCCCCGCCCACATCTAGAACGACA
CTCGCCTATGGGGACATGAACCACGAGTGGATCGGCAACGAGTGGCTCCCCAGCCTGGGCCTCCCCCAGTACCGCAGCTACTTCATGGAG
TGCCTTGTAGACGCCAGGATGCTGGACCACTTGACCAAGAAAGACCTTCGAGGGCAGCTGAAAATGGTCGACAGTTTTCACAGAAACAGT
TTCCAGTGTGGAATTATGTGCCTGAGAAGGTTAAATTATGACCGGAAAGAACTGGAAAGAAAAAGAGAAGAAAGTCAGAGTGAAATAAAA
GACGTGCTTGTTTGGAGCAATGATCGAGTGATTCGCTGGATCCTGTCAATTGGCCTTAAAGAATATGCAAACAATCTTATAGAGAGTGGT
GTTCACGGAGCACTTCTGGCCTTAGATGAAACCTTCGACTTCAGTGCACTGGCACTGCTGTTACAGATCCCGACGCAGAACACACAGGCT
CGTGCTGTCTTGGAAAGAGAATTTAACAACCTTTTGGTCATGGGGACTGATAGAAGGTTTGATGAAGATGATGATAAAAGCTTTAGGAGA
GCACCTTCATGGAGAAAAAAGTTTAGACCAAAGGACATTCGTGGCTTAGCTGCTGGGTCAGCAGAGACTCTCCCTGCAAACTTCCGGGTG
ACTTCTTCTATGTCTTCCCCCTCTATGCAGCCAAAGAAGATGCAGATGGACGGTATGTGATGGGTCACACTAACCTGTCACTTGTTGGGA
GCATGAGCAGCTTTCTGTCTGGAACATTAATAATGATCTAAAACGGCCTATTTAATATGTTACAAGGCACTTGAGTATGGTTGCATGTCC
AAATATAAATGTTTTTAAATTAACTCTAACATTTGTTTATAAAAGTTTAACCATAATAATAGAATTTTTAAAACACGCTTGTCTGGTTGA
ATCTTAGCATATTTTTCCAACTAATAAAGCTCAGTATTCGTCTGTGTTCTCAGAGAGAGACTGAGGCATACTTGTAAATTTGTGTCTGTG

>66884_66884_2_POLA2-PPFIA1_POLA2_chr11_65047097_ENST00000265465_PPFIA1_chr11_70200407_ENST00000389547_length(amino acids)=725AA_BP=1
MGGPAPRPLAWATMSASAQQLAEELQIFGLDCEEALIEKLVELCVQYGQNEEGMVGELIAFCTSTHKVGLTSEILNSFEHEFLSKRLSKA
RHSTCKDSGHAGARDIVSIQELIEVEEEEEILLNSYTTPSKGSQKRAISTPETPLTKRSVSTRSPHQLLSPSSFSPSATPSQKYNSRSNR
GEVVTSFGLAQGVSWSGRGGAGNISLKVLGCPEALTGSYKSMFQKLPDIREVLTCKIEELGSELKEHYKIEAFTPLLAPAQLPPSREEVR
DDKTTIKCETSPPSSPRALRLDRLHKGALHTVSHEDIRDIRNSTGSQDGPVSNPSSSNSSQDSLHKAPKKKGIKSSIGRLFGKKEKGRPG
QTGKEALGQAGVSETDNSSQDALGLSKLGGQAEKNRKLQKKHELLEEARRQGLPFAQWDGPTVVVWLELWVGMPAWYVAACRANVKSGAI
MSALSDTEIQREIGISNPLHRLKLRLAIQEIMSLTSPSAPPTSRTTLAYGDMNHEWIGNEWLPSLGLPQYRSYFMECLVDARMLDHLTKK
DLRGQLKMVDSFHRNSFQCGIMCLRRLNYDRKELERKREESQSEIKDVLVWSNDRVIRWILSIGLKEYANNLIESGVHGALLALDETFDF
SALALLLQIPTQNTQARAVLEREFNNLLVMGTDRRFDEDDDKSFRRAPSWRKKFRPKDIRGLAAGSAETLPANFRVTSSMSSPSMQPKKM

--------------------------------------------------------------
>66884_66884_3_POLA2-PPFIA1_POLA2_chr11_65047097_ENST00000541089_PPFIA1_chr11_70200407_ENST00000253925_length(transcript)=3806nt_BP=950nt
AGTTCTGCCACCGTCACTGAGAAGCTCAGCGGTAGCTTTTGGGAAGCAGGACGTTCTCACCAGGAGAGCGTCCTCTCGAGATTTCTGCTC
CCTCCATTCAGGGCGTTTGGGAGCCACCCCTTCATTTTTTAAAAAAAGTATTTCTCTGTGACCGACGGCCGGGGCCTTCTGACGGTCTGA
GGTCTTGCTTGGGCCAGTCACCTCCTGTCACGGTCCGCGGAGGGGGGAAGGATAAGAGGGCGAGGAGCTCATCGCTCGCCACCCCCGTGG
GCTTCTTGGGCGCAGGTCGGAGCTGGGTGGGCCGGCTCCCCGGCCCCTGGCTTGGGCGACCATGTCCGCATCCGCCCAGCAGCTGGCGGA
GGAGCTGCAGATCTTCGGCCTAGACTGCGAGGAGGCTCTAATTGAGAAATTTTCTGAGCAAAAGATTATCGAAAGCCAGGCATAGTACCT
GCAAGGACAGTGGCCATGCAGGAGCTAGAGACATTGTTTCCATTCAAGAGCTAATTGAAGTGGAAGAAGAAGAGGAAATCCTCTTGAACT
CTTACACCACACCTTCAAAGGGTTCTCAGAAGCGAGCTATCTCTACCCCAGAAACCCCCCTAACAAAAAGGAGTGTGTCAACTCGTAGCC
CCCATCAGCTACTCTCACCGTCAAGTTTCTCTCCAAGTGCTACTCCCTCCCAGAAATACAACTCACGAAGTAACCGAGGAGAAGTGGTTA
CCTCCTTCGGCTTAGCACAGGGAGTATCTTGGTCTGGGAGAGGAGGAGCTGGAAACATCAGCCTGAAGGTCTTGGGATGTCCAGAGGCAC
TAACTGGGAGCTACAAATCCATGTTTCAGAAGCTCCCAGACATTCGAGAAGTTCTGACCTGTAAGATAGAAGAACTTGGCAGCGAACTCA
AGGAACATTACAAGATTGAAGCTTTCACTCCTTTGCTAGCCCCAGCACAGTTGCCACCTTCCAGAGAAGAGGTACGAGATGACAAGACAA
CCATAAAGTGTGAAACCTCCCCGCCTTCCTCCCCGAGAGCCCTTCGGTTAGACCGGCTGCACAAAGGGGCGCTGCACACCGTCAGCCACG
AGGACATCAGGGACATAAGGAACTCCACAGGCTCCCAGGATGGTCCCGTGAGCAACCCCAGCAGTAGCAACAGTAGCCAGGACTCGCTCC
ACAAAGCCCCAAAGAAGAAAGGCATTAAGTCCTCCATTGGCCGCTTGTTTGGCAAGAAAGAAAAGGGCCGACCTGGACAAACTGGCAAAG
AAGCATTAGGACAAGCTGGTGTTTCCGAGACGGATAACTCATCTCAGGATGCCTTGGGACTTAGCAAATTGGGGGGACAGGCTGAAAAAA
ATCGTAAACTTCAAAAAAAGCATGAATTGCTGGAGGAAGCCCGGAGACAAGGTTTACCTTTTGCCCAATGGGACGGGCCAACGGTTGTGG
TCTGGCTAGAGCTCTGGGTTGGGATGCCAGCCTGGTATGTGGCTGCCTGCCGAGCAAACGTGAAAAGCGGGGCCATCATGTCGGCCCTGT
CCGACACAGAGATCCAGCGTGAGATTGGCATCAGCAACCCCCTGCACAGGCTGAAGCTGAGGCTGGCCATCCAGGAGATCATGTCGCTGA
CCAGCCCGTCTGCCCCGCCCACATCTAGAACGACACTCGCCTATGGGGACATGAACCACGAGTGGATCGGCAACGAGTGGCTCCCCAGCC
TGGGCCTCCCCCAGTACCGCAGCTACTTCATGGAGTGCCTTGTAGACGCCAGGATGCTGGACCACTTGACCAAGAAAGACCTTCGAGGGC
AGCTGAAAATGGTCGACAGTTTTCACAGAAACAGTTTCCAGTGTGGAATTATGTGCCTGAGAAGGTTAAATTATGACCGGAAAGAACTGG
AAAGAAAAAGAGAAGAAAGTCAGAGTGAAATAAAAGACGTGCTTGTTTGGAGCAATGATCGAGTGATTCGCTGGATCCTGTCAATTGGCC
TTAAAGAATATGCAAACAATCTTATAGAGAGTGGTGTTCACGGAGCACTTCTGGCCTTAGATGAAACCTTCGACTTCAGTGCACTGGCAC
TGCTGTTACAGATCCCGACGCAGAACACACAGGCTCGTGCTGTCTTGGAAAGAGAATTTAACAACCTTTTGGTCATGGGGACTGATAGAA
GGTTTGATGAAGATGATGATAAAAGCTTTAGGAGAGCACCTTCATGGAGAAAAAAGTTTAGACCAAAGGACATTCGTGGCTTAGCTGCTG
GGTCAGCAGAGACTCTCCCTGCAAACTTCCGGGTGACTTCTTCTATGTCTTCCCCCTCTATGCAGCCAAAGAAGATGCAGATGGACGGCA
ATGTATCAGGAACACAGAGGTTGGATTCTGCTACAGTCAGGACTTACTCCTGCTAAAGTCTCCTGTTGTTTACCCACACTACTTCTACAG
ATGATTATGCAGCATTTGAATCCAACAAAGACTACATTTTGGAATCCAGTGGAATCTTTAATCTTGTTAATACTTGTTATATGGACCCTA
AGATATTTTATTACAGAGTTTTTAATTAGTGAAAAATTCATGAATACCATAGAGAAAATATTTTAGAATTTAATGTTTCTTATATTTATG
TAAACTTATGACTCTTCATTTATATAGTTACTTACTTTTTCATGTATATCCAGGCTATAAATATCCTTTCAAATCATGTTCTTATACCTA
ATTTTAGTCTTTCAAATGAATGTACTGTAATGCTTGTATGTATAAATCCTATGAATAGAGGGCTTTTGTAAATTATGCATTTATTGTAAT
TATCATTAATTTTTTAATGATAAACCATGACAAAGGATTTTACGTTTATAAAATTATGACAGAAGCCATGTGCATTATCCTTTACGGACG
CAGCCTAGCTCTACAGCAATCATCCTGAAATAAGCATACCTAATTTCAAGCAATTGTTGTATTTTCATGACTGACCTTAACTGTACTTTT
TCTAGCAAGAGATGCTTTATTCTGCAGCATGAACAGATTTAAAATGGCTGGTGTTAAATATCAGCTCCTAATAAGATGTGGACTGAAAAC
ACTATCACAACACTATGAGAAGCCCCTAGCACTGGTTAACGCTTTCCTAGCCTAGTCTCTGGATTTGGGGAGCTTGTCTTCAGTGGCTGA
GACTGTGAGCTGGGAGCAGTTCTCTCAGCTGGAGAGACTCGGGATGGGGTAACCTGGGGACCAGTCTAGCCCCTGCACCCTCTTCCCTGC
CTCTGCTCCTTGGGAGCGGGTGGAGAGACACCCATGTGGCTCCCCTTAGGGCCAGCACCAAGCACCACGCTCTCATCCTGCAAGTCGGCG
CACACAGTGGATGAAGGCAGGAGACCCAGAAAGCAGTGCAGTGCAGCTCTAATAAAGGCCTTATTTTTCTTATGTAAATCATCTTTTTAC
ATTTGTTTGTAAACATGTTTAAAGAACGAACCTAGTGGGACATTTTTAGACTTTGATGCTCTAGCCATTTTGGATTGTGTAAGTTGCAGA
TGTGGCTTTTACTTTTTAAATGGCATATTAACAAGCCAGCAAAGTGTGTCAGACCATGGCGTGGTATTTATTGTGCAGCAGATCCAGAGA
CAGAGGCAGCCTGTCTTTTCAGTTGGTTTCTGCTTTTAATTTACTTGTACAATTCATTGTTACTGTTCTGTTTTTCTATTAATCTTTTGT
CAACTTCCTGATTATGTAACAAAGTATGTACAGTCTACTTTTGAACTATTTTTATCACAGTATTATTTATTGCTTTCTTTCAATAAAGTA

>66884_66884_3_POLA2-PPFIA1_POLA2_chr11_65047097_ENST00000541089_PPFIA1_chr11_70200407_ENST00000253925_length(amino acids)=664AA_BP=182
MRNFLSKRLSKARHSTCKDSGHAGARDIVSIQELIEVEEEEEILLNSYTTPSKGSQKRAISTPETPLTKRSVSTRSPHQLLSPSSFSPSA
TPSQKYNSRSNRGEVVTSFGLAQGVSWSGRGGAGNISLKVLGCPEALTGSYKSMFQKLPDIREVLTCKIEELGSELKEHYKIEAFTPLLA
PAQLPPSREEVRDDKTTIKCETSPPSSPRALRLDRLHKGALHTVSHEDIRDIRNSTGSQDGPVSNPSSSNSSQDSLHKAPKKKGIKSSIG
RLFGKKEKGRPGQTGKEALGQAGVSETDNSSQDALGLSKLGGQAEKNRKLQKKHELLEEARRQGLPFAQWDGPTVVVWLELWVGMPAWYV
AACRANVKSGAIMSALSDTEIQREIGISNPLHRLKLRLAIQEIMSLTSPSAPPTSRTTLAYGDMNHEWIGNEWLPSLGLPQYRSYFMECL
VDARMLDHLTKKDLRGQLKMVDSFHRNSFQCGIMCLRRLNYDRKELERKREESQSEIKDVLVWSNDRVIRWILSIGLKEYANNLIESGVH
GALLALDETFDFSALALLLQIPTQNTQARAVLEREFNNLLVMGTDRRFDEDDDKSFRRAPSWRKKFRPKDIRGLAAGSAETLPANFRVTS

--------------------------------------------------------------
>66884_66884_4_POLA2-PPFIA1_POLA2_chr11_65047097_ENST00000541089_PPFIA1_chr11_70200407_ENST00000389547_length(transcript)=2722nt_BP=950nt
AGTTCTGCCACCGTCACTGAGAAGCTCAGCGGTAGCTTTTGGGAAGCAGGACGTTCTCACCAGGAGAGCGTCCTCTCGAGATTTCTGCTC
CCTCCATTCAGGGCGTTTGGGAGCCACCCCTTCATTTTTTAAAAAAAGTATTTCTCTGTGACCGACGGCCGGGGCCTTCTGACGGTCTGA
GGTCTTGCTTGGGCCAGTCACCTCCTGTCACGGTCCGCGGAGGGGGGAAGGATAAGAGGGCGAGGAGCTCATCGCTCGCCACCCCCGTGG
GCTTCTTGGGCGCAGGTCGGAGCTGGGTGGGCCGGCTCCCCGGCCCCTGGCTTGGGCGACCATGTCCGCATCCGCCCAGCAGCTGGCGGA
GGAGCTGCAGATCTTCGGCCTAGACTGCGAGGAGGCTCTAATTGAGAAATTTTCTGAGCAAAAGATTATCGAAAGCCAGGCATAGTACCT
GCAAGGACAGTGGCCATGCAGGAGCTAGAGACATTGTTTCCATTCAAGAGCTAATTGAAGTGGAAGAAGAAGAGGAAATCCTCTTGAACT
CTTACACCACACCTTCAAAGGGTTCTCAGAAGCGAGCTATCTCTACCCCAGAAACCCCCCTAACAAAAAGGAGTGTGTCAACTCGTAGCC
CCCATCAGCTACTCTCACCGTCAAGTTTCTCTCCAAGTGCTACTCCCTCCCAGAAATACAACTCACGAAGTAACCGAGGAGAAGTGGTTA
CCTCCTTCGGCTTAGCACAGGGAGTATCTTGGTCTGGGAGAGGAGGAGCTGGAAACATCAGCCTGAAGGTCTTGGGATGTCCAGAGGCAC
TAACTGGGAGCTACAAATCCATGTTTCAGAAGCTCCCAGACATTCGAGAAGTTCTGACCTGTAAGATAGAAGAACTTGGCAGCGAACTCA
AGGAACATTACAAGATTGAAGCTTTCACTCCTTTGCTAGCCCCAGCACAGTTGCCACCTTCCAGAGAAGAGGTACGAGATGACAAGACAA
CCATAAAGTGTGAAACCTCCCCGCCTTCCTCCCCGAGAGCCCTTCGGTTAGACCGGCTGCACAAAGGGGCGCTGCACACCGTCAGCCACG
AGGACATCAGGGACATAAGGAACTCCACAGGCTCCCAGGATGGTCCCGTGAGCAACCCCAGCAGTAGCAACAGTAGCCAGGACTCGCTCC
ACAAAGCCCCAAAGAAGAAAGGCATTAAGTCCTCCATTGGCCGCTTGTTTGGCAAGAAAGAAAAGGGCCGACCTGGACAAACTGGCAAAG
AAGCATTAGGACAAGCTGGTGTTTCCGAGACGGATAACTCATCTCAGGATGCCTTGGGACTTAGCAAATTGGGGGGACAGGCTGAAAAAA
ATCGTAAACTTCAAAAAAAGCATGAATTGCTGGAGGAAGCCCGGAGACAAGGTTTACCTTTTGCCCAATGGGACGGGCCAACGGTTGTGG
TCTGGCTAGAGCTCTGGGTTGGGATGCCAGCCTGGTATGTGGCTGCCTGCCGAGCAAACGTGAAAAGCGGGGCCATCATGTCGGCCCTGT
CCGACACAGAGATCCAGCGTGAGATTGGCATCAGCAACCCCCTGCACAGGCTGAAGCTGAGGCTGGCCATCCAGGAGATCATGTCGCTGA
CCAGCCCGTCTGCCCCGCCCACATCTAGAACGACACTCGCCTATGGGGACATGAACCACGAGTGGATCGGCAACGAGTGGCTCCCCAGCC
TGGGCCTCCCCCAGTACCGCAGCTACTTCATGGAGTGCCTTGTAGACGCCAGGATGCTGGACCACTTGACCAAGAAAGACCTTCGAGGGC
AGCTGAAAATGGTCGACAGTTTTCACAGAAACAGTTTCCAGTGTGGAATTATGTGCCTGAGAAGGTTAAATTATGACCGGAAAGAACTGG
AAAGAAAAAGAGAAGAAAGTCAGAGTGAAATAAAAGACGTGCTTGTTTGGAGCAATGATCGAGTGATTCGCTGGATCCTGTCAATTGGCC
TTAAAGAATATGCAAACAATCTTATAGAGAGTGGTGTTCACGGAGCACTTCTGGCCTTAGATGAAACCTTCGACTTCAGTGCACTGGCAC
TGCTGTTACAGATCCCGACGCAGAACACACAGGCTCGTGCTGTCTTGGAAAGAGAATTTAACAACCTTTTGGTCATGGGGACTGATAGAA
GGTTTGATGAAGATGATGATAAAAGCTTTAGGAGAGCACCTTCATGGAGAAAAAAGTTTAGACCAAAGGACATTCGTGGCTTAGCTGCTG
GGTCAGCAGAGACTCTCCCTGCAAACTTCCGGGTGACTTCTTCTATGTCTTCCCCCTCTATGCAGCCAAAGAAGATGCAGATGGACGGTA
TGTGATGGGTCACACTAACCTGTCACTTGTTGGGAGCATGAGCAGCTTTCTGTCTGGAACATTAATAATGATCTAAAACGGCCTATTTAA
TATGTTACAAGGCACTTGAGTATGGTTGCATGTCCAAATATAAATGTTTTTAAATTAACTCTAACATTTGTTTATAAAAGTTTAACCATA
ATAATAGAATTTTTAAAACACGCTTGTCTGGTTGAATCTTAGCATATTTTTCCAACTAATAAAGCTCAGTATTCGTCTGTGTTCTCAGAG
AGAGACTGAGGCATACTTGTAAATTTGTGTCTGTGACAGGCCGTGCTAGAAAGCTCTTTCAGGAAATAGTAGTGTAGTAGTAGCTTCCAA

>66884_66884_4_POLA2-PPFIA1_POLA2_chr11_65047097_ENST00000541089_PPFIA1_chr11_70200407_ENST00000389547_length(amino acids)=647AA_BP=182
MRNFLSKRLSKARHSTCKDSGHAGARDIVSIQELIEVEEEEEILLNSYTTPSKGSQKRAISTPETPLTKRSVSTRSPHQLLSPSSFSPSA
TPSQKYNSRSNRGEVVTSFGLAQGVSWSGRGGAGNISLKVLGCPEALTGSYKSMFQKLPDIREVLTCKIEELGSELKEHYKIEAFTPLLA
PAQLPPSREEVRDDKTTIKCETSPPSSPRALRLDRLHKGALHTVSHEDIRDIRNSTGSQDGPVSNPSSSNSSQDSLHKAPKKKGIKSSIG
RLFGKKEKGRPGQTGKEALGQAGVSETDNSSQDALGLSKLGGQAEKNRKLQKKHELLEEARRQGLPFAQWDGPTVVVWLELWVGMPAWYV
AACRANVKSGAIMSALSDTEIQREIGISNPLHRLKLRLAIQEIMSLTSPSAPPTSRTTLAYGDMNHEWIGNEWLPSLGLPQYRSYFMECL
VDARMLDHLTKKDLRGQLKMVDSFHRNSFQCGIMCLRRLNYDRKELERKREESQSEIKDVLVWSNDRVIRWILSIGLKEYANNLIESGVH
GALLALDETFDFSALALLLQIPTQNTQARAVLEREFNNLLVMGTDRRFDEDDDKSFRRAPSWRKKFRPKDIRGLAAGSAETLPANFRVTS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for POLA2-PPFIA1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for POLA2-PPFIA1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for POLA2-PPFIA1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource