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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:POLB-HOOK3 (FusionGDB2 ID:66888) |
Fusion Gene Summary for POLB-HOOK3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: POLB-HOOK3 | Fusion gene ID: 66888 | Hgene | Tgene | Gene symbol | POLB | HOOK3 | Gene ID | 11232 | 84376 |
| Gene name | DNA polymerase gamma 2, accessory subunit | hook microtubule tethering protein 3 | |
| Synonyms | HP55|MTDPS16|MTPOLB|PEOA4|POLB|POLG-BETA|POLGB | HK3 | |
| Cytomap | 17q23.3 | 8p11.21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | DNA polymerase subunit gamma-2, mitochondrialDNA polymerase gamma accessory 55 kDa subunitmitochondrial DNA polymerase subunit gamma-2mitochondrial DNA polymerase, accessory subunitp55polymerase (DNA directed), gamma 2, accessory subunitpolymerase ( | protein Hook homolog 3h-hook3hHK3hook homolog 3 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | Q86VS8 | |
| Ensembl transtripts involved in fusion gene | ENST00000265421, ENST00000538005, ENST00000521492, ENST00000530566, | ENST00000524839, ENST00000307602, | |
| Fusion gene scores | * DoF score | 6 X 3 X 4=72 | 14 X 10 X 7=980 |
| # samples | 8 | 16 | |
| ** MAII score | log2(8/72*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(16/980*10)=-2.61470984411521 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: POLB [Title/Abstract] AND HOOK3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | POLB(42202537)-HOOK3(42761316), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | POLB | GO:0006261 | DNA-dependent DNA replication | 10608893|15167897|19837034|19858216|26123486|26446790|28430993 |
| Hgene | POLB | GO:1900264 | positive regulation of DNA-directed DNA polymerase activity | 10608893|19837034|19858216|26123486 |
| Fusion gene breakpoints across POLB (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across HOOK3 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | READ | TCGA-DY-A0XA-01A | POLB | chr8 | 42202537 | + | HOOK3 | chr8 | 42761316 | + |
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Fusion Gene ORF analysis for POLB-HOOK3 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000265421 | ENST00000524839 | POLB | chr8 | 42202537 | + | HOOK3 | chr8 | 42761316 | + |
| 5UTR-3CDS | ENST00000538005 | ENST00000307602 | POLB | chr8 | 42202537 | + | HOOK3 | chr8 | 42761316 | + |
| 5UTR-intron | ENST00000538005 | ENST00000524839 | POLB | chr8 | 42202537 | + | HOOK3 | chr8 | 42761316 | + |
| In-frame | ENST00000265421 | ENST00000307602 | POLB | chr8 | 42202537 | + | HOOK3 | chr8 | 42761316 | + |
| intron-3CDS | ENST00000521492 | ENST00000307602 | POLB | chr8 | 42202537 | + | HOOK3 | chr8 | 42761316 | + |
| intron-3CDS | ENST00000530566 | ENST00000307602 | POLB | chr8 | 42202537 | + | HOOK3 | chr8 | 42761316 | + |
| intron-intron | ENST00000521492 | ENST00000524839 | POLB | chr8 | 42202537 | + | HOOK3 | chr8 | 42761316 | + |
| intron-intron | ENST00000530566 | ENST00000524839 | POLB | chr8 | 42202537 | + | HOOK3 | chr8 | 42761316 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000265421 | POLB | chr8 | 42202537 | + | ENST00000307602 | HOOK3 | chr8 | 42761316 | + | 14497 | 356 | 170 | 2455 | 761 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000265421 | ENST00000307602 | POLB | chr8 | 42202537 | + | HOOK3 | chr8 | 42761316 | + | 0.000255256 | 0.9997447 |
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Fusion Genomic Features for POLB-HOOK3 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| POLB | chr8 | 42202537 | + | HOOK3 | chr8 | 42761315 | + | 5.26E-11 | 1 |
| POLB | chr8 | 42202537 | + | HOOK3 | chr8 | 42761315 | + | 5.26E-11 | 1 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for POLB-HOOK3 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:42202537/chr8:42761316) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | HOOK3 |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Probably serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25035494). FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997). {ECO:0000250|UniProtKB:Q8BUK6, ECO:0000269|PubMed:11238449, ECO:0000269|PubMed:17237231, ECO:0000269|PubMed:18799622, ECO:0000269|PubMed:25035494, ECO:0000269|PubMed:32073997}.; FUNCTION: (Microbial infection) May serve as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking. {ECO:0000305}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | HOOK3 | chr8:42202537 | chr8:42761316 | ENST00000307602 | 0 | 22 | 167_433 | 19 | 719.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | HOOK3 | chr8:42202537 | chr8:42761316 | ENST00000307602 | 0 | 22 | 462_667 | 19 | 719.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | HOOK3 | chr8:42202537 | chr8:42761316 | ENST00000307602 | 0 | 22 | 553_718 | 19 | 719.0 | Region | Note=Required for association with Golgi |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | POLB | chr8:42202537 | chr8:42761316 | ENST00000265421 | + | 3 | 14 | 183_192 | 62 | 336.0 | Region | Note=DNA binding |
| Tgene | HOOK3 | chr8:42202537 | chr8:42761316 | ENST00000307602 | 0 | 22 | 10_126 | 19 | 719.0 | Domain | Calponin-homology (CH) |
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Fusion Gene Sequence for POLB-HOOK3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >66888_66888_1_POLB-HOOK3_POLB_chr8_42202537_ENST00000265421_HOOK3_chr8_42761316_ENST00000307602_length(transcript)=14497nt_BP=356nt AACAAGCGCCGTGCGCCCCGCCCCCCATCGGGGGCAACCATTGTTCCGCCGGTCGCGCCGGAGCTGGGTTGCTCCTGCTCCCGTCTCCAA GTCCTGGTACCTCCTTCAAGCTGGGAGAGGGCTCTAGTCCCTGGTTCTGAACACTCTGGGGTTCTCGGGTGCAGGCCGCCATGAGCAAAC GGAAGGCGCCGCAGGAGACTCTCAACGGGGGAATCACCGACATGCTCACAGAACTCGCAAACTTTGAGAAGAACGTGAGCCAAGCTATCC ACAAGTACAATGCTTACAGAAAAGCAGCATCTGTTATAGCAAAATACCCACACAAAATAAAGAGTGGAGCTGAAGCTAAGAAATTGATCC AGACATTTAATGTGGATGCACCATGCCAGACCGTGGAAGATTTAACGAATGGGGTTGTGATGGCCCAGGTTCTTCAAAAGATAGATCCTG CATATTTTGATGAAAATTGGCTAAACAGAATCAAAACTGAAGTAGGAGATAATTGGAGGCTAAAGATAAGCAATTTAAAGAAAATTTTAA AAGGAATCTTGGATTATAATCATGAGATTTTAGGACAGCAAATTAATGACTTTACCCTTCCTGATGTGAACCTTATTGGGGAGCATTCTG ATGCAGCAGAGCTTGGAAGGATGCTTCAGCTCATCTTAGGCTGTGCTGTGAACTGTGAACAGAAGCAAGAGTACATCCAAGCCATTATGA TGATGGAGGAATCTGTTCAACATGTTGTCATGACAGCCATTCAAGAGCTGATGAGTAAAGAATCTCCTGTCTCTGCTGGAAATGATGCCT ATGTTGACCTTGATCGTCAGCTGAAGAAAACTACAGAGGAACTAAATGAAGCTTTGTCAGCAAAGGAAGAAATTGCTCAAAGATGCCATG AACTGGATATGCAGGTTGCAGCATTGCAGGAAGAGAAAAGTAGTTTGTTGGCAGAGAATCAGGTATTAATGGAAAGACTCAATCAATCTG ATTCTATAGAAGACCCTAACAGTCCAGCAGGAAGAAGGCATTTGCAGCTCCAGACTCAATTAGAACAGCTCCAAGAAGAAACATTCAGAC TAGAAGCAGCCAAAGATGATTATCGAATACGTTGTGAAGAGTTAGAAAAGGAGATCTCTGAACTTCGGCAACAGAATGATGAACTGACCA CTTTGGCAGATGAAGCTCAGTCTCTGAAAGATGAGATCGACGTGCTGAGACATTCTTCTGATAAAGTATCTAAACTAGAAGGTCAAGTAG AATCTTATAAAAAGAAGCTAGAAGACCTTGGTGATTTAAGGCGGCAGGTTAAACTCTTAGAAGAGAAGAATACCATGTATATGCAGAATA CTGTCAGTCTAGAGGAAGAGTTAAGAAAGGCCAACGCAGCGCGAAGTCAACTTGAAACCTACAAGAGACAGGTAGTAGAACTACAAAACA GATTATCCGAAGAATCAAAGAAAGCAGATAAACTAGATTTTGAATATAAGCGGCTAAAAGAAAAAGTTGACAGTCTTCAAAAAGAAAAGG ACAGGCTGAGAACAGAAAGGGATTCTCTGAAGGAAACCATTGAAGAGCTTCGTTGTGTACAAGCTCAAGAAGGGCAGCTCACAACACAAG GGTTAATGCCTCTTGGAAGTCAGGAGTCTTCAGACAGTCTAGCTGCAGAGATTGTTACACCTGAAATCAGGGAGAAACTTATTCGTCTTC AGCATGAGAATAAGATGTTAAAGCTTAACCAAGAAGGTTCGGACAATGAAAAAATAGCCTTATTGCAGAGCCTTCTAGATGATGCAAATC TACGCAAGAATGAACTGGAGACAGAGAATAGGCTGGTGAATCAAAGACTTCTGGAAGTACAGTCACAAGTTGAAGAATTACAAAAATCTT TACAGGATCAAGGCTCAAAAGCAGAAGATTCAGTCCTTCTAAAAAAGAAGCTTGAAGAACATCTAGAGAAGCTGCATGAGGCCAATAATG AACTACAGAAGAAGAGAGCCATTATTGAAGATCTCGAGCCAAGATTTAACAACAGCTCCTTAAAAATTGAAGAATTACAAGAAGCTTTAC GAAAGAAAGAGGAAGAAATGAAGCAAATGGAAGAACGATACAAAAAATACTTAGAGAAAGCCAAAAGTGTCATCCGTACTTTAGATCCTA AACAGAATCAAGGAGCAGCACCAGAAATACAAGCTCTTAAAAATCAGCTCCAGGAACGAGACCGACTGTTCCACTCATTAGAGAAAGAAT ATGAGAAAACAAAGAGTCAGAGAGAGATGGAAGAGAAATATATTGTTAGTGCCTGGTACAATATGGGAATGACCCTGCATAAAAAGGCAG CTGAAGATAGACTGGCAAGCACAGGCTCAGGGCAGTCATTTCTGGCGAGGCAGAGGCAAGCGACCAGCAGCAGAAGATCATACCCAGGCC ACGTGCAGCCGGCCACAGCAAGGTAGAGAAGTTGTGCCGCTCAATCACAGACACCTGCACCCACAACATACTTCTGTTACACACAAGAAC ATTTCAGGAAACTCAGCCAGCTTATTTTTTGTTTCTCTTCTATGTCAATACTTAGTGTTTCTCATTTTGAGGACTTTTTCTCTCTCCTGT ATCTTTGTTTTAGTTTCTTTGGTTTTTATTTTGTAGTCCTTTCAGTTATTTTTAATGTGCCAAAAATTTGTACATGTTCAATTAAAAATG TTGTATAATAGTGTAATACTTTTCTTTGTATGAAAATGTCCTCTTCTTCAAAGGTATAGGCTTTGTAATGAATTAGATTTTCTGCCAATA ATTGATATACAATTTATATTCTTTATTGTGCCTGTGTGTTACCATGCTAAGAATGTCTTTGTTTAAAGGGAATTAATCTTTTTATGATGT ATTAATCTGTGTTTTCAATTGTTTTCCAAGTACAGTTCAAATAACTTGCATATTTACTATACAAAATGGTTGACAAGTGTTCTTTTTGCA AAGACTTGAATACATTGGCAGAGGTGCTAATCACATCTTCCCTAAGGCACCTGGAAGAATTATTTGAGGAAAAAATGAGTTTTCACATTG TTTTATAGGAAATTAAATTTGTCCAAAGATTTGGAGACTATTTTTAAAACATAAATACATAAAATTTCATTATTTCCTGCTATCTTGTTT GCTGGCAGAAGTGAATGTTTGGTGAGGTTATTTTGGGATAAATTACAAAAGAAAAAAAATTAGACACTGCATTAATTTCTTGTTCTTTTG GAATATCTTAGTAACTGAGGATCATTTTCTAACAATGTGGTTGACATACCTTCAGTTGCTTTCCACATCTAAAAGAGTTATCTTTCATAT ATGTACAAGTTATTGGTAGTCTTATTTTTGGGCTGTTTGTTGACTTATGCCCCATTTGTTTTACTTGTTCTTTAATATAAACCCTTCCAT TTTTTAACAATTCCTAACACTTGATATCTTAATATCAGTCACTAACATTAGTAACTTCTTGTATGTTATATTATGGCAGATCTCTTTACG TTTTTTCTCACATCTATCTGCTAGTCCAGGAATTTGTTACTAAATAGATTTTCTTGGATATTTGGTTGCCTCAAAGTGCTTACATTTGTT AACAGATTGTAAACCACATTTATTTACATTGATGAATGGGCTGTTGAATAATCATTGTAAAGCACTTTGTATATATAAGGTGCTATATAA GTGTGAAATATCATTCATTTATAAATGAAATGCCTTCTAACTTTCCATATTGACTTATGTATTTGGTCCCAAATTATATTTAAGTCTTTT TTCTTGCAACGTAGCCCATTTTTTGAAAGCAAAACATTTCTGAAATTAGGTCATGGTTTTTTTGTTTATTTTTAGGTTAGGTCACTTAAT ATAGGAGGATGTTTTCTCATGTACTTGCTATTTGCAAGTTCAGGTTTCATTTGGTTCTTTATGTTAAATACGAATAAGTAACCTCAAATC AAGCTAAATGTAATTAAGAATTTTCAGCAACTATATTCAAGTGTTTGATTTTTAAATTCTTTCTTTCTTTTTAATAAGAAAGATGACCTA AAAATCAGTGGTATTTGTTTGTCCTCAGAAGCCGTAGTTGAAGAAAGATATTAGAGTATACACAGAACTGGAGCCATACATTGTGCTAAT TTTTTACATTAAGTACAGAAGTCTGAGCACAGCATGAATGCTTCTGCCTGACAGGACCACAAAGCAGCAGAAGTTAGGGATAAATGGAGA TAGCCATGAGTAGAACTGCTGTAGGGCTTCAGGAGGCTACGCAGACCTGATCAACTGCAAAGTTTCCAAAGTAAAAGATTAAAAACTTTC AGACGGTTCTTACCTCTACCCGTGTTTCACAAATAGCCTGAGGATCCAACTATTTTTAAAGCAAATTGGGGCCAGACGTGGTGCCTCACG CCTGCAATCTCACCATTTGGGAGACCTAGGTGGGGGTGGATCACTTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACCC CATCTCTACTAAATTACAAAAATTAGCTGGGCATGGTGGCATGTGGCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAGTCACTT GAACTCAGGAGCCAGAGACTGCAGTGAGCTGAGATCGCACCACTGCATTCCAGCCTGGGCGACAGAGTGAGACTCTGTCTCAATCAGTCA ATCAATCAATCAATCAAATTGGAATATGAGCACTAACCTTGGTAAGTTAAAATTTTGGGAAAATTGTACCTGCAGAATATGATGGATGAA AACAACAGCCAGGTGCAGTGGCTCACGCGTATAATCCCAGCACTTTGGGAGGCCGAGACAGGCACATCATCTGAGGTCAGGACTTCCAGA CCAGCCTGTCCAACATGGTGAAACTCCGTCTCTACTAAAAATACAAACAATTAGCCAGGCATGGTGGTGTGTGCCTGTAGTCCCAGCTAC TTGGGAGGGTGAGGCAGGAGAATTGCTTGAACCTGGGAGACAGAGATTGCAGTGAGCCGAGATGGCGCCATTGCACCCCAGCCTGGCGAC AAGAGCGAAACTCTGTCGCAAGAAAAAAAAAAAAAAAAAAAAAAAAAAAAACAGTCTGTGAACTACTCACTGAATGAATTTTGTTCTGTG AGATGAGAGGTTTTCATTTTCATTTTCTATTTACAGCCCCAGTCCTAATCTCCTACCCATCCACCTACCCAGATATTTTTTCTCTATCTG GGTTGGAAAGGCCCCAGGCTTTTAGAGGGGAGTTTTACTTCTGACTTTTTTTTCCCCCCGAGACGGAGCCTCGTTCCGTCACCCAGGCTG TAGTGCCGTGGCATGATCTCGGCTCACTGCAGCCTCTGCCTCCCGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCAGAGTAGCTGGGATT ACAGGTGCCCACCACCATGGCTGGCTAATTTTTGTAATTTAGTAGAGATGGTGTTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTGA CCTCGTGATCTACCCACCTCGGCCTCCCAAAGTGCTGAGATTACAGGCACGAGCCACCGCGCCCAGTCGTACTTCTGACTTTTCTTCAGC ATCTGTTGTATGCTATTATTTTGATGTTTACATTTATAATTTTCTTTCTTTTTTTTTTTTTTGTGAGATGATGTCTCGCTCTGTCACCCA GGCTGGAGTGCAGTGGCGCGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCGG GGACTACAGGCGCCCGCCACTACGCCCGACTAATTTTTTGTATTTTTTAGTAGAGACGGGGTTTCACCATGTTAGCCAGGATGGTCTCGA TCTCCTGACCTCGTGATCCACCCGCCTCAGCCTCCCAGAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCCAGCCTACATTTATAATTT TCATTCTCTTTTACCTATAAAATTCAGTGTATTAGTTTCATTACATAGGAGAAATTATATTTCTAAACATTTTATGATGTTTAAAAACAA AACAGGCTGTTGTAAAAAAAAAAAAAAAAAAAACTTCTGAATATACTTTAGGTATCAGAAAGCCAAGAATAAAATTTAGCTCTAACGGTG GCAACTCCATGTCCGGTGTCCAGCTTTGGACAGGGTTTATGACGTTTCTGTTTCTCTAGTAATGATTAATGATTCCTCAGGAGATTCGTG ATGTTGTCTGGTCTATCTGGAAATTTAAAGTCACTAGGAGCTTTGCCTCATCGTGAGTGATGCTGTGCTGTATTTTTACAAACTCTCGCA TACAGCACCTTCCTGGGGCCACGTTGGCTTGTGCAGTGGAGCTTGTCCAGGCACCAGCATGGAGCAAGTACAGGGTTGCTGTGTTGGGTT GGAGCACACTGTCACCACAGTGTCTGAAGTCTTATAAACAGGAAGATCATTTTCTGTTTTCCTTCTAACCAGGGTGAGAAAATACAAAGT AAAGAACTAAAGAATATTAAAACCTAGCATTTATGTTCCACAGTGTGTATTTCAGAAGTTTGTAATCCAGAAAATATAGTAGTGTATAAT ATCTGAAAAGAGAATCAAGTATACAATTGTACATATTTTTAAAGAACTTTGAAAAACTCCGTCATATCTTTTACCATTTGTCTATTTGAT AGTAATGCAGAAAAAAGTCCCTAAAGACCCTGTGTTCCAAAATTTACCAAGATTGACATTTCTATTAGACATCCTTAACCTAAGTGTTTT AATTAGATTATTAGACTATAATAAGGATGAAATTGCTGTCTGTAATTTTGTTGAGGTTTTATTGTTAATATAATAAAAGCTCAACTGTAC AAAATTAAGCTAAATGTTATCCAGTCAGAAACATCAGCCTGTGGCCAGGTGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCC AAGGCAGGCGGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCTAATATGGTGAAACCCCATCTCTACTAAAAATACAGTATTAGCC AGGCATGGTGGCAGGCGCCTGTGATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCATGTGAACCCAGGAGGTGGAGGTTGCAGTAAG CCGAGATTGTGCCACTGCACTCCAGCCTGGGCCACAGAGTGAGACTCCATCTCAAAAAAAAAAAAAAAAAAAAAAAGAAACATCAGCCTG TATATTCCAGTAGTTCTCACAGAAGAATGAAAATCCGTGCTGTGCAAATAGATCAGTAGTGAGTGAGTGTTAAGTGAAAGATGAGCTAGG TTGAAGAAAATATACATTTTATTGATGAGCCACTTTGCTATCTCTCCTTCCTTCCTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCC CTTCTTTTCTTTTTTCTTTTCTTTTCTTTTCTCCCTCCTTTCTTCCTTCCCTTCCCTTCCCCTCCCCTCCCCCAGGCTGGAGTGCAGAGG CACGATCCTGGCTGACTGCAAACTCTGCCTACCAGGTTCAAGCGATTCTCCTGCCTCATCCTCCCTAGTAGCTAGGATTACAGGCATCTG CCACCACGCCCAGCTAATTTTTGTATTTTTACAAAATACAAAGAGACGGGGTTTCACCATGTTGGCCAGGCTGGTCTCTAACTCCTGACC TCAGGTGATCCGTCCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGTGTTACTGCCCCAGCCTCCTATTTCCTTTTCGAAAGTAG CAGTTTGGTTTATTCTCGTTTGCTAAGTAATTGTTTGAAATATTTTTCAGCCTCTCCTGCTCCCTCACAAAAATTCACCTGTCATTTTAA TGATAACAGCATGTTAAAAACTTGGAAGTCTTTATCCCAATATAAGAATTATCTTGAAACAAAAATCTAAATTACTTTTAAAAATTCTCT TAACTCTGCATTTAGTCTCCTATTATCTAGATCTCTGAGTCCAGGATAACTCCAGTTATCCCCAGTTGGATCATGTGTGATTTATCTGAG AAAGCATCCACAACCCACAGCTAGTGGAAACCGAGCTAGTTTACAGCCACGTGGATAAGAACATCTTTGTTTCTAAAGTGAGAGGAAAGT GCTTGGTATCTTGCTTTTTGCTGAGGGCAAAATAACAACATGAAGACAAAGTGCTTTTTGTTGTCTATTCATGAAACTGTAGAAGAATAT TTTGAGTTTTTATTCTTATATTATGAAGGGATTCTTTGCCTAGCAGTGGCCGTCAAACTGATGTAGCATTGTACTTCTCAACAGTGAAGC CTGTGTAATACCATACAGTAGGATGAAAGACTATTCTGAGCAAAATCAAATGGGATGTCAGAATCTTTGAAAATTATTTTATCATTTTTT CTATTTTTTCATTTTTATAAATTAGAAGGATTTTCCATTCAATAAGGATAATCTCTCTTCCTATCATTCTGTCAAAATGGCAGTTTCTTT TGGTAATTATCCAACCTAGTTTCATTACATTTAGAAGGAGGTTTCAGAGCTTATTCTTGATAACTATAATAATGATTTGAATGTTTTATA TCATGAAGTTTTTTCTATGAGGAAGGCTATTCTCAATGTATCTGTCGTCTAATTTTTTATTTTCTATCTATAAAGAATATTTAAATAATA ATTGGTGTATGTTCCTTTTGTTGAAAATGTTTTATTGTCCAGTTTTAACACAGAAGTGGTCTAAAGTTTTGCAGCAAATGCTGTTCAGTT CCCAGAAGCCTAAAAAACATAACATAATATGCTAACAGAGCTAATTTCCACCCAATCCCTCAAATTACCGAAGTATTAATATTTAGCTTC CTTTCTAGAAAACAAGGGGCAGCACAAATGGGGTGGCATCCATCTCTTTTAAATCACTGATGATTTTCTGGGGAAGTATATATAGATGAT TTTATTTTTTAAATAGCCTTTTATCAAACCATTTCACATGTATTATCTATATGACTATAGAAACTTATAAAACATTTAATTCATGTTGAC TTAAAACATGGGCATCCTTGGATTCTCCACATTGACTGAAATGATAGAGAAAGGGACATTTGTTTGAGAAACAAGAGACCTGTACCTAAT TATGGCAAGTATATGAGTTTTGGTGATTGTGGGGGGTTATAAATGTTTTCCTATGATAGATAAATATATAGATATAGATCAGGAATTACT TGATGTCTCTTCAGAAGTTTTCTGTTTTCTTATAATTTCCAGTAATACTCTGTAAGACTCGGTTTGCATGCTGTGTGTGTTTGCATGAGT ATAGAAACCTAAGAACATAATGGAAGGCTATTAAGGCAAATTCATTCCTAGAAAGTGGAGTGGATCATTGGGATAAGAAATAGCCTAATT ATAAACAAATATGCAGGCAGAGGGAAGTCCTAATACAATGAAAACTTGCATTATCTAAACAGATGTTCCCAAAGCAATAGTTTGCCTAAA ATCCTCTGTATTACATGATTATTCAGTAAAAGAGTAAACAAATATCTAATTTATTTTCTAATTGTCCTTCCCTTCATTGAGTATTAACTA GGTGCATAATGTAGTTGTATATGTTTACTAGTAAAGGGAAAAACACTTATTTTCATTTTGAGACTGTTTGGCTATTACTAAAGCTGAGAA AGTGATTTTAGGTCGCCAAGGATACTATGATTTGATGAGATGAGAAGAAATCTGCGGTGGCTGAAAATCGTGACCAACTTGGTGTTATCT AGATCTGCTTTATCTAGTTTGCAAGCCATAGGCTCAATTTTATGTCCTTCTTACTTACACACAGTAGCCCCACACAGTTTTGTTTTAAAT GAAGGCAAAAGTAGACATTTTTAAAGTATATTCAACATTGTGCCATTATTTACCTGATAAAGGTGAAATCAGAGGTGTCCACGGCCTCAA AGTTTGGGCCCATGGGACTATCAAATCCGAATTATATCTACTTAGAGCTTAGAGGAAGAATTAGGTATCATGAGAAAAGCAACTCCTACT TGAGAGAAAGAAGACTACCAAAGCATGTTGAGGCTTTAACATGGGAGACTTCCAGGTAGGCGTTAACACTTGAGTGGTAACTAGCTTGAT GAAGGAAAATAATTACTTTAGCAGTTATGTTGTAAAATTAATAAAAAGGACTCATGTTTATTCTGGTGTATTTGTCAACCCATGGGTAGT GATTACTCCGTGTACATTCTATAGTGTGTGTATTTTATTTAGTGTCTTAATATATAGTCTTTATATAGTATCTTAATATTATTTACTGTT ACTTCTAGTCATTTATGTAGTATATTTTACTGCAAAATTTGTAGCACTTTACTAATATTAGATCATTATTTTCCCTCTTCCCCTCTACCT TTCTGGCATTTTCTGTTATCTTAGAGTCAGGAATCTAAAGGTCTAAGTCTAGAAATCTGTTGGAAGCTGGGTTGGAGCTACTGGATATGA GTTACTTTTTACATGTCTCCTTAAGAAGACTCTTTTATAATGTAATACTTAGAAGCCAAATCCTTTCAAACGCAAACACCCTTGAAACTT GATGCTTTCTGAAGTTGTATTCATAAAAATTATCCCATCTTACAGTTAATCAGAAGATGTTCTTACCTTTGGTTTGCCTGCCTCCTGAAA CACAAACCTGCAGATTGCCCCTAACTTCAGCAGTGCCTCCGTCACTGCATGTACCTAAAAGACAGGAAAGCCAAGTTCTGGGAGCTGTCA AGTCGGAGGATCAGGAAAATGGTGGGGAAGAGGTGACTGGAAAGGCAGGCACTAAAGATGGCAGGCTGCAAAAGCATTCTGAGTTCCCCT GTAACAGATAGGTTTTATGAACTCAGCTGTTTTCTTTTTTCTTTTTTTTTCTTTTGAGATGGAGTCTCACTCTGAGTCTCACTCTGTTGC CCAGGCTGGAGTGCAGTGGCACAATCTCAGCTCACTGCAGCCTCCACCTCCCGGTTTCAAGTGATTCTCCCACCTCAGCCTCCCGAGTAG TTAGGATTACAGGTGCCCACCACCACGCCCAACTAATTTTTGTATTTTTAGTAAAGACAGGGTGTCGCCATATTGGCTAGGCTGGTTTTG AACTCCTGACCTCAGGTAATCCACCCGCCTCAGCCTCCCAAAGTGCTGGGATTATTATAGGCGTGAGCCACCATGCCCAGTGAACTTGGC CATTTTCTTACATTCATATATAGCAAAGTTTTCAACTTGTCTACCGAGAGACTTTCTTTAGGAGCCAGGACTTCTACATTTGTAACTTGA GTATATTAATATTCAAATCATAGTTCAAAAATACTGAAATACTTGTTTATTATGTTACATAAATATGGACACAATTACTGCCAAAGAATA GAGAGATTTGCTTATGAGAACATTCTGTCATTTGTTCTGTTTGTAGATGAGAGACATGCTTTTAAAGTACAAAACGTTTCTCTTCTACCT TACCCCCTGTTCTACTGACGTGCTTTGCATGAGAAGCTCATCTAGAAGAGAGCAACGCTGGAATAGAGAAGTCTAGACCCTGGCCTTTGA GGGAAAGGACTGCTTTTTTTCTCTCCCAAATTAGAAAATTAAAAGTGAAACATAACACATAAGGACGAAATACAATGTTCTGAATATCTT CCACTAATTAATTGTTGAATGATTAAGTCTCTAAGTATCTTAACTTCCATTGTCTTCTTGTTAACCTAGACAAGAGTAGATTATTCAGTA GCCACATGTGACAGTTAAAATTAAGTAAAATTAAAACTATAGTTTCTCAGTGGCCTAGCCACATTTCAAGTGTTCCACAGTCACATGTGG ATAGTAGTTACCTATCAGACAGTACAGGTATAGAACATTTCCAGTATTGCCAAAAATGCTATTCAACAGCACTTTTATTGCCCAGAGAGA AAATAAGGACAAAATAAAGGCAGTGAAGTAACTTAAGACAACTCTGAGATTTTACCACCATACTTAGAGAAAGTTTTTCTGTTATAAAAA TTAATACTAATCCTTTTTAAAGACCTTGGAAAAAATCAAAACCCCATTCCTTTAAGCTAGTCTTCAGTATATATTTTTCTAAGAACAGAT TCTCAATACTTTATTTTTCAAGTGATAAAATCATTTTATAAATCATTTCTTAATATCTTCAGTGTTTTTTCCCTTTTTATGTAAACTCTT TTAAAATTGATATTAGCTGGGCATGGTAGCTCATGCCTGTAGTCCCAGCTACTCCAGAGGTCGAGGCAGGAGCATCGCTTAAGCCCAGGA GGTTCAGGCTGCAGTAAGGTCTGATCACACCTGACTGCACTCCAGCCTGGGTGGCAAAGCAAGACCCCTGTCTCTAAAAAAAAATAATAT AAATTGATGTTATATAGTTAACATTTATCAGGCAAATTCATATGAATGCTTATTTCAAATAAAGATTGATAGATTTAATGATATCCTTCC TTTTAAATTTATATAGATCTAATGAACATTGCCAACAGTTTTTTTTGTTTCTGTCCCTTAAACATTTCCCCTGAAAGTCCACCTCAAAGG TACATCAAGATGCAAACAATTTTTTTATCTTCATAACTTCCTGCTCTTATTAACTTGTATTATGAATCAAATTAAGTTTTATGTATAAGG CATTTACTATTCCAGTGACTTAGCTAATGAAAACATTTAAAAATATGTATTAATTTACTTGGCCTGCTACTAAAGTGCTTAACATAACTA AATGGATCTATAGTAACATGTCTAAATTTTTTAATGGAAATAAGGGACTAACCATAATCCTTTTGAGTCAGCTTGGTGCTTACAATTATT TTGTTAGGAAATCTTGATGCTTTCTTCTTTCTCTTTAAATTTTTGTAATCAAGCAACAGACTTGATCCAGCAGTGTCGAATTCCAAGCAA GTTATGATGATTCTTATTGTAGTTCAAGTACAGATGAGTAAGTGGTGTGACTTCAGTTTATTATCTTCTTGGTGACCTACTTTAGTATGT GTTCTGTAGCGATTCATATTAGTTAAGGGACGTTTTCAATATGCTTGAAATAAGAAATAGCATTTTACTCTAAATACAAGAAATGACTGT ACACAAATGCTAATCAGTGATTTGGGGCCTTTTAATGTCTTTAACAGCAATCTTTTATTTATTTATTTATTTATTTTTGAGACGGAGTCT TGCTGTGTCACCAGGCTGGAGCAGTGGCACGATCTCGCCTCACTGCAACCTCCGCCTCCCAGGTTCAAGCTATTCTCCTGCCTCAGCCTC CCAAGTAACTGGGACTGCAGGCACATGCCACCACATCCAGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCTTGTTGGCCAGGA TGATCTCGATCTCTTGATCTCGTGATCTGCCCGCATTGGCCTCCTGAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGGCCCAAAT CTTTTATTTTTTAACAGCCTTAGTTATTTATAATTCAAATGCACTAAAATATCATCGCTGTCATGAACTTTGCTGTTTACAGGTTCTGTG TAATTCAGAATGCTTTGTACTTAGAAAATAATTTCTAGGCTTATCTTGTTTTGCAGTTTTCATGTTTTGACAATTGCCCACCATTTACAA TACTCAATTTTTGATTATGAAATGAATAGTAAAATTCAAACATATCTAATAATAATTTGCCTTAGTTTGATTAATAAATTATATCAAAAA ACTTGGGGATAGAAAGAGGCTTTTTTTTCCCCCTGTAGTATTTTTAAAACTTTTTAGATGAGCTGGATGAAACCTTAGTACATTGGAGCT GGAGTTGTATTGAGTACAGCCCCAACTCTGAAGCCTTATATTCATGTCTTAAGTACCATTGATTGTTCTGTGAATTGTTGTTAGTTTCAT ATTTGACATTGTAGTAATCCACCTTGCATTTTAGTCTTTGCAAAAAGGATATTGCTAGGTATATTCTTATTTCTGATTGAGTATTGAATT TACATTTTTCAGAATTTCATTCTTTGTCATTATAATCCAAAAACAATGTCCACATCAGACTTGGAACTTCTCACTTCAAAAATGAAATAC AGATTTAGCAGTGTTGTACATAATGATGTCCAAGCATTTTTCCACCTGTTTACTGAGTTTTCCAACCATTTACTATGTGTTGAGATTGGT GGGTTTTCTGGCTGTTTTTCTGAGGTGAATGACTTGTTACAGAGCCTCAGTAAGAAATTTCAACTAAAATCACAAAAACATAAAGTCCAG GAAACCACCAGAAGATGGATTTTTAGTGTTTTTGAAATCTTGTATTTCCTTTTGATATCATTTACTCATTTTAATTTTACGACTGCCAAC TTGTTACGGTATTAATTATATGTATGTGTTTATATGTATGCATATAATATATGTATATGTATATGAAGAATAAAGTTAAGATTTGGTCAA ACTATATTTTCCCATTCAAGTACAAAAATGTTTTCAAGGCTGCAAAAAGTGTACAGTTGTTAAACAAGTTGTAAATAAAGACTTGTATAA >66888_66888_1_POLB-HOOK3_POLB_chr8_42202537_ENST00000265421_HOOK3_chr8_42761316_ENST00000307602_length(amino acids)=761AA_BP=0 MSKRKAPQETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLIQTFNVDAPCQTVEDLTNGVVMAQVLQK IDPAYFDENWLNRIKTEVGDNWRLKISNLKKILKGILDYNHEILGQQINDFTLPDVNLIGEHSDAAELGRMLQLILGCAVNCEQKQEYIQ AIMMMEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERL NQSDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADEAQSLKDEIDVLRHSSDKVSKLE GQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQ KEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQHENKMLKLNQEGSDNEKIALLQSLLD DANLRKNELETENRLVNQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSLKIEELQ EALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQERDRLFHSLEKEYEKTKSQREMEEKYIVSAWYNMGMTLH -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for POLB-HOOK3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for POLB-HOOK3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for POLB-HOOK3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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