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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:POLB-UVRAG (FusionGDB2 ID:66892)

Fusion Gene Summary for POLB-UVRAG

check button Fusion gene summary
Fusion gene informationFusion gene name: POLB-UVRAG
Fusion gene ID: 66892
HgeneTgene
Gene symbol

POLB

UVRAG

Gene ID

11232

7405

Gene nameDNA polymerase gamma 2, accessory subunitUV radiation resistance associated
SynonymsHP55|MTDPS16|MTPOLB|PEOA4|POLB|POLG-BETA|POLGBDHTX|VPS38|p63
Cytomap

17q23.3

11q13.5

Type of geneprotein-codingprotein-coding
DescriptionDNA polymerase subunit gamma-2, mitochondrialDNA polymerase gamma accessory 55 kDa subunitmitochondrial DNA polymerase subunit gamma-2mitochondrial DNA polymerase, accessory subunitp55polymerase (DNA directed), gamma 2, accessory subunitpolymerase (UV radiation resistance-associated gene proteinbeclin 1 binding proteindisrupted in heterotaxy
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000265421, ENST00000538005, 
ENST00000521492, ENST00000530566, 
ENST00000531818, ENST00000532130, 
ENST00000533454, ENST00000539288, 
ENST00000525872, ENST00000538870, 
ENST00000356136, ENST00000528420, 
Fusion gene scores* DoF score6 X 3 X 4=7228 X 21 X 11=6468
# samples 836
** MAII scorelog2(8/72*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(36/6468*10)=-4.16725086714399
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: POLB [Title/Abstract] AND UVRAG [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPOLB(42202537)-UVRAG(75719851), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePOLB

GO:0006261

DNA-dependent DNA replication

10608893|15167897|19837034|19858216|26123486|26446790|28430993

HgenePOLB

GO:1900264

positive regulation of DNA-directed DNA polymerase activity

10608893|19837034|19858216|26123486

TgeneUVRAG

GO:0071900

regulation of protein serine/threonine kinase activity

22542840

TgeneUVRAG

GO:0097352

autophagosome maturation

28306502

TgeneUVRAG

GO:0097680

double-strand break repair via classical nonhomologous end joining

22542840


check buttonFusion gene breakpoints across POLB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across UVRAG (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-95-8039-01APOLBchr8

42202537

-UVRAGchr11

75719851

+
ChimerDB4LUADTCGA-95-8039-01APOLBchr8

42202537

+UVRAGchr11

75719851

+
ChimerDB4LUADTCGA-95-8039POLBchr8

42202537

+UVRAGchr11

75719850

+


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Fusion Gene ORF analysis for POLB-UVRAG

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000265421ENST00000531818POLBchr8

42202537

+UVRAGchr11

75719851

+
5CDS-5UTRENST00000265421ENST00000531818POLBchr8

42202537

+UVRAGchr11

75719850

+
5CDS-5UTRENST00000265421ENST00000532130POLBchr8

42202537

+UVRAGchr11

75719851

+
5CDS-5UTRENST00000265421ENST00000532130POLBchr8

42202537

+UVRAGchr11

75719850

+
5CDS-5UTRENST00000265421ENST00000533454POLBchr8

42202537

+UVRAGchr11

75719851

+
5CDS-5UTRENST00000265421ENST00000533454POLBchr8

42202537

+UVRAGchr11

75719850

+
5CDS-5UTRENST00000265421ENST00000539288POLBchr8

42202537

+UVRAGchr11

75719851

+
5CDS-5UTRENST00000265421ENST00000539288POLBchr8

42202537

+UVRAGchr11

75719850

+
5CDS-intronENST00000265421ENST00000525872POLBchr8

42202537

+UVRAGchr11

75719851

+
5CDS-intronENST00000265421ENST00000525872POLBchr8

42202537

+UVRAGchr11

75719850

+
5CDS-intronENST00000265421ENST00000538870POLBchr8

42202537

+UVRAGchr11

75719851

+
5CDS-intronENST00000265421ENST00000538870POLBchr8

42202537

+UVRAGchr11

75719850

+
5UTR-3CDSENST00000538005ENST00000356136POLBchr8

42202537

+UVRAGchr11

75719851

+
5UTR-3CDSENST00000538005ENST00000356136POLBchr8

42202537

+UVRAGchr11

75719850

+
5UTR-3CDSENST00000538005ENST00000528420POLBchr8

42202537

+UVRAGchr11

75719851

+
5UTR-3CDSENST00000538005ENST00000528420POLBchr8

42202537

+UVRAGchr11

75719850

+
5UTR-5UTRENST00000538005ENST00000531818POLBchr8

42202537

+UVRAGchr11

75719851

+
5UTR-5UTRENST00000538005ENST00000531818POLBchr8

42202537

+UVRAGchr11

75719850

+
5UTR-5UTRENST00000538005ENST00000532130POLBchr8

42202537

+UVRAGchr11

75719851

+
5UTR-5UTRENST00000538005ENST00000532130POLBchr8

42202537

+UVRAGchr11

75719850

+
5UTR-5UTRENST00000538005ENST00000533454POLBchr8

42202537

+UVRAGchr11

75719851

+
5UTR-5UTRENST00000538005ENST00000533454POLBchr8

42202537

+UVRAGchr11

75719850

+
5UTR-5UTRENST00000538005ENST00000539288POLBchr8

42202537

+UVRAGchr11

75719851

+
5UTR-5UTRENST00000538005ENST00000539288POLBchr8

42202537

+UVRAGchr11

75719850

+
5UTR-intronENST00000538005ENST00000525872POLBchr8

42202537

+UVRAGchr11

75719851

+
5UTR-intronENST00000538005ENST00000525872POLBchr8

42202537

+UVRAGchr11

75719850

+
5UTR-intronENST00000538005ENST00000538870POLBchr8

42202537

+UVRAGchr11

75719851

+
5UTR-intronENST00000538005ENST00000538870POLBchr8

42202537

+UVRAGchr11

75719850

+
In-frameENST00000265421ENST00000356136POLBchr8

42202537

+UVRAGchr11

75719851

+
In-frameENST00000265421ENST00000356136POLBchr8

42202537

+UVRAGchr11

75719850

+
In-frameENST00000265421ENST00000528420POLBchr8

42202537

+UVRAGchr11

75719851

+
In-frameENST00000265421ENST00000528420POLBchr8

42202537

+UVRAGchr11

75719850

+
intron-3CDSENST00000521492ENST00000356136POLBchr8

42202537

+UVRAGchr11

75719851

+
intron-3CDSENST00000521492ENST00000356136POLBchr8

42202537

+UVRAGchr11

75719850

+
intron-3CDSENST00000521492ENST00000528420POLBchr8

42202537

+UVRAGchr11

75719851

+
intron-3CDSENST00000521492ENST00000528420POLBchr8

42202537

+UVRAGchr11

75719850

+
intron-3CDSENST00000530566ENST00000356136POLBchr8

42202537

+UVRAGchr11

75719851

+
intron-3CDSENST00000530566ENST00000356136POLBchr8

42202537

+UVRAGchr11

75719850

+
intron-3CDSENST00000530566ENST00000528420POLBchr8

42202537

+UVRAGchr11

75719851

+
intron-3CDSENST00000530566ENST00000528420POLBchr8

42202537

+UVRAGchr11

75719850

+
intron-5UTRENST00000521492ENST00000531818POLBchr8

42202537

+UVRAGchr11

75719851

+
intron-5UTRENST00000521492ENST00000531818POLBchr8

42202537

+UVRAGchr11

75719850

+
intron-5UTRENST00000521492ENST00000532130POLBchr8

42202537

+UVRAGchr11

75719851

+
intron-5UTRENST00000521492ENST00000532130POLBchr8

42202537

+UVRAGchr11

75719850

+
intron-5UTRENST00000521492ENST00000533454POLBchr8

42202537

+UVRAGchr11

75719851

+
intron-5UTRENST00000521492ENST00000533454POLBchr8

42202537

+UVRAGchr11

75719850

+
intron-5UTRENST00000521492ENST00000539288POLBchr8

42202537

+UVRAGchr11

75719851

+
intron-5UTRENST00000521492ENST00000539288POLBchr8

42202537

+UVRAGchr11

75719850

+
intron-5UTRENST00000530566ENST00000531818POLBchr8

42202537

+UVRAGchr11

75719851

+
intron-5UTRENST00000530566ENST00000531818POLBchr8

42202537

+UVRAGchr11

75719850

+
intron-5UTRENST00000530566ENST00000532130POLBchr8

42202537

+UVRAGchr11

75719851

+
intron-5UTRENST00000530566ENST00000532130POLBchr8

42202537

+UVRAGchr11

75719850

+
intron-5UTRENST00000530566ENST00000533454POLBchr8

42202537

+UVRAGchr11

75719851

+
intron-5UTRENST00000530566ENST00000533454POLBchr8

42202537

+UVRAGchr11

75719850

+
intron-5UTRENST00000530566ENST00000539288POLBchr8

42202537

+UVRAGchr11

75719851

+
intron-5UTRENST00000530566ENST00000539288POLBchr8

42202537

+UVRAGchr11

75719850

+
intron-intronENST00000521492ENST00000525872POLBchr8

42202537

+UVRAGchr11

75719851

+
intron-intronENST00000521492ENST00000525872POLBchr8

42202537

+UVRAGchr11

75719850

+
intron-intronENST00000521492ENST00000538870POLBchr8

42202537

+UVRAGchr11

75719851

+
intron-intronENST00000521492ENST00000538870POLBchr8

42202537

+UVRAGchr11

75719850

+
intron-intronENST00000530566ENST00000525872POLBchr8

42202537

+UVRAGchr11

75719851

+
intron-intronENST00000530566ENST00000525872POLBchr8

42202537

+UVRAGchr11

75719850

+
intron-intronENST00000530566ENST00000538870POLBchr8

42202537

+UVRAGchr11

75719851

+
intron-intronENST00000530566ENST00000538870POLBchr8

42202537

+UVRAGchr11

75719850

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000265421POLBchr842202537+ENST00000356136UVRAGchr1175719851+32393561701456428
ENST00000265421POLBchr842202537+ENST00000528420UVRAGchr1175719851+18383561701456428
ENST00000265421POLBchr842202537+ENST00000356136UVRAGchr1175719850+32393561701456428
ENST00000265421POLBchr842202537+ENST00000528420UVRAGchr1175719850+18383561701456428

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000265421ENST00000356136POLBchr842202537+UVRAGchr1175719851+0.0003900180.99961
ENST00000265421ENST00000528420POLBchr842202537+UVRAGchr1175719851+0.0015372240.9984628
ENST00000265421ENST00000356136POLBchr842202537+UVRAGchr1175719850+0.0003900180.99961
ENST00000265421ENST00000528420POLBchr842202537+UVRAGchr1175719850+0.0015372240.9984628

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Fusion Genomic Features for POLB-UVRAG


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
POLBchr842202537+UVRAGchr1175719850+3.61E-050.9999639
POLBchr842202537+UVRAGchr1175719850+3.61E-050.9999639
POLBchr842202537+UVRAGchr1175719850+3.61E-050.9999639
POLBchr842202537+UVRAGchr1175719850+3.61E-050.9999639

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for POLB-UVRAG


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:42202537/chr11:75719851)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePOLBchr8:42202537chr11:75719850ENST00000265421+314183_19262336.0RegionNote=DNA binding
HgenePOLBchr8:42202537chr11:75719851ENST00000265421+314183_19262336.0RegionNote=DNA binding
TgeneUVRAGchr8:42202537chr11:75719850ENST00000356136915224_305333700.0Coiled coilOntology_term=ECO:0000255
TgeneUVRAGchr8:42202537chr11:75719851ENST00000356136915224_305333700.0Coiled coilOntology_term=ECO:0000255
TgeneUVRAGchr8:42202537chr11:75719850ENST0000035613691523_149333700.0DomainC2
TgeneUVRAGchr8:42202537chr11:75719851ENST0000035613691523_149333700.0DomainC2


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Fusion Gene Sequence for POLB-UVRAG


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>66892_66892_1_POLB-UVRAG_POLB_chr8_42202537_ENST00000265421_UVRAG_chr11_75719850_ENST00000356136_length(transcript)=3239nt_BP=356nt
AACAAGCGCCGTGCGCCCCGCCCCCCATCGGGGGCAACCATTGTTCCGCCGGTCGCGCCGGAGCTGGGTTGCTCCTGCTCCCGTCTCCAA
GTCCTGGTACCTCCTTCAAGCTGGGAGAGGGCTCTAGTCCCTGGTTCTGAACACTCTGGGGTTCTCGGGTGCAGGCCGCCATGAGCAAAC
GGAAGGCGCCGCAGGAGACTCTCAACGGGGGAATCACCGACATGCTCACAGAACTCGCAAACTTTGAGAAGAACGTGAGCCAAGCTATCC
ACAAGTACAATGCTTACAGAAAAGCAGCATCTGTTATAGCAAAATACCCACACAAAATAAAGAGTGGAGCTGAAGCTAAGAAATTGAATG
AACATAAGGATTACTTTGTATGCGGTGTCAAGTTGCCTAATTCTGAGGACTTCCAAGCAAAAGATGATGGAAGCATTGCTGTTGCCCTTG
GTTATACTGCACATCTGGTCTCCATGATTTCCTTTTTCCTACAAGTGCCCCTCAGATATCCTATAATTCATAAGGGGTCTAGATCAACAA
TCAAAGACAATATCAATGACAAACTGACGGAAAAGGAGAGAGAGTTTCCACTGTATCCAAAAGGAGGGGAGAAGTTGCAGTTTGATTATG
GTGTCTATCTTCTGAACAAAAATATAGCACAGCTAAGATATCAACATGGACTAGGGACTCCAGACTTGCGGCAAACCCTTCCCAACCTGA
AAAACTTCATGGAGCATGGACTAATGGTCAGGTGTGACAGACATCACACCTCCAGTGCAATCCCTGTTCCTAAGAGACAAAGCTCCATAT
TTGGGGGTGCAGATGTAGGCTTCTCTGGGGGGATCCCTTCACCAGACAAAGGACATCGAAAACGGGCCAGCTCTGAGAATGAGAGACTTC
AGTACAAAACCCCTCCTCCCAGTTACAACTCAGCATTAGCCCAGCCTGTGACCACCGTCCCCTCCATGGGAGAGACCGAGAGAAAGATAA
CATCTCTATCCTCCTCCTTGGATACCTCCTTGGACTTCTCCAAAGAAAACAAGAAAAAAGGAGAGGATCTAGTTGGCAGCTTAAACGGAG
GCCACGCGAATGTGCACCCTAGCCAAGAACAAGGAGAAGCCCTCTCCGGGCACCGGGCCACAGTCAATGGCACTCTCCTACCCAGCGAGC
AGGCCGGGTCCGCCAGTGTCCAGCTTCCAGGCGAGTTCCACCCAGTCTCAGAAGCTGAGCTCTGCTGTACTGTGGAGCAAGCAGAAGAAA
TCATCGGGCTGGAAGCCACAGGTTTCGCCTCAGGTGATCAGCTAGAAGCATTTAACTGCATCCCAGTGGACAGTGCTGTGGCAGTAGAGT
GTGACGAACAAGTTCTGGGAGAATTTGAAGAGTTCTCCCGAAGGATCTATGCACTGAATGAAAACGTATCCAGCTTCCGCCGGCCGCGCA
GGAGTTCCGATAAGTGAAGTGAGCAGGTCAACAGTAGGACTGGGGCAGAAGCTCTGCCTAAAATGAAGTGAAAGCTGCACTTAACCCTTT
GTGATAATGATGACACAAAATGAATATTAATGGAGGATATTCCTCGGAAAAACAGACTTTGGGAATGAAGGAGGGACTCAGGATCATTGT
TATCAGTGGGCCAAAGTTAGATTTTGCTTTCAAGATTTGCTTTTCGGGCCTGATGATTTTAAAGCAAAAATCACCCTCTAGTTGAAAGAG
CTTACAGCTCGAGTCACCTTTTAGCTATTTGTCTGCTTTTTATTTACCCTTGTATGTTATCCTCAGAGGGAAGATGATAATATATAAATA
ATATAATGAACACACCCTTAGTTTCTCATAAGCATTTGCCCTCACCATGGTTTATAAAACTTTGGGAAAACGGAATATTCAGAAATAGGT
TTCCGCCATGTACTGAAAGGTCTGTGGCCATCTGTGAGGTAGATGAAGAAGCAGCATAGTGGTCTCCTTACATCTAGGCCTAACTGTCCC
TCTTCCTGCCCCCGGGTACCACAGTCCACCTTTAGACCCTACTGTCGCCCCATCTTCTCCGTGGATGGGCCATGCGTCCTGAAAACAGGA
CATCAGATTCACTGGTTCTGTAACCCAGTAGCTGTGACGTTCCATCTCTTCTAACCAGCCATGGCCTTCCCCTCCTCTGCCATACCCTTA
ATGCGGCCCTCAGATTAGATGAAAAACTTGCTCCTGGTGGATCCCAAGGGACCCTCAAGGACCTCGAGGTTACTGCAGTCAGATGCCATC
TCATCCCCTGTGGGGGCCAAAGTTTTTATGTGGGCAGATGCTGTGGTCAGGAACTAGGCATGCTTTCTGGCAATGCACTCACCAGACAAA
AATCCCTTGATGTAAATCCCATGTTAATTTATTAAATTTCAGTCAGAAGGTCAGCATTTACATGACAGAATGTATGTAGAGAGTTGGGGT
GTCTGGTAGGCAAACTGCAAGGCAGTTGAGATAGTTGGATTAAGAGGCTAGACGAGACATAGAATACTATTGGTATGTGTGCAATTTCAT
GAATATTAAATTATGTTTCGAAGTCCAGTTGTCATTCCCGCATTCAGATTTCATTTGCTGTTGCTTTATACGTTACGTACCCAAGGACAT
TGCCTCAGGGTTGCAAACTCTTTAAAGGAAAATTTATCCATATATCCATGTATTATATAGAAGAATAAAAATTGAGTTTACTTCACCCGA
CCTGATTTTTTTTTACCAGCTTGGAAATTCCTCTTGAACCTACGTCTCCATATGTCACATCATGACAGGACTAGCCTGAACAAAAGCCAT
GTCTATCTAAGCGGAGGCTGTTGACTTCATTCAGTTTGCATATTGTATATAGCAACACAAACACTTGACAGGTATATACTCCAGTCGCCA
CATTTGTCCTGCATAACAGCTTCACTCACAGGCCTCACCGTCACTTTATTTTGTGTCCAAGCATTCCTGGGCTCAAGTTTAATGTATAGC
TACATTGTTGTTTTCCATGTAGAGAACTCACAGGATGACTACATCACAAATAAACCCAACTCTCAGGCAGTCGAAAGCTTTAACTGGATC
TGCAGAAGCCCATCTTCCTCCACATGAAGAAGTGGGGCTCCTTCACCTAGAGCAGGAGCTTCTCTGCAGTGTACTGTCTGTCGCTCATTT

>66892_66892_1_POLB-UVRAG_POLB_chr8_42202537_ENST00000265421_UVRAG_chr11_75719850_ENST00000356136_length(amino acids)=428AA_BP=62
MSKRKAPQETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLNEHKDYFVCGVKLPNSEDFQAKDDGSIA
VALGYTAHLVSMISFFLQVPLRYPIIHKGSRSTIKDNINDKLTEKEREFPLYPKGGEKLQFDYGVYLLNKNIAQLRYQHGLGTPDLRQTL
PNLKNFMEHGLMVRCDRHHTSSAIPVPKRQSSIFGGADVGFSGGIPSPDKGHRKRASSENERLQYKTPPPSYNSALAQPVTTVPSMGETE
RKITSLSSSLDTSLDFSKENKKKGEDLVGSLNGGHANVHPSQEQGEALSGHRATVNGTLLPSEQAGSASVQLPGEFHPVSEAELCCTVEQ

--------------------------------------------------------------
>66892_66892_2_POLB-UVRAG_POLB_chr8_42202537_ENST00000265421_UVRAG_chr11_75719850_ENST00000528420_length(transcript)=1838nt_BP=356nt
AACAAGCGCCGTGCGCCCCGCCCCCCATCGGGGGCAACCATTGTTCCGCCGGTCGCGCCGGAGCTGGGTTGCTCCTGCTCCCGTCTCCAA
GTCCTGGTACCTCCTTCAAGCTGGGAGAGGGCTCTAGTCCCTGGTTCTGAACACTCTGGGGTTCTCGGGTGCAGGCCGCCATGAGCAAAC
GGAAGGCGCCGCAGGAGACTCTCAACGGGGGAATCACCGACATGCTCACAGAACTCGCAAACTTTGAGAAGAACGTGAGCCAAGCTATCC
ACAAGTACAATGCTTACAGAAAAGCAGCATCTGTTATAGCAAAATACCCACACAAAATAAAGAGTGGAGCTGAAGCTAAGAAATTGAATG
AACATAAGGATTACTTTGTATGCGGTGTCAAGTTGCCTAATTCTGAGGACTTCCAAGCAAAAGATGATGGAAGCATTGCTGTTGCCCTTG
GTTATACTGCACATCTGGTCTCCATGATTTCCTTTTTCCTACAAGTGCCCCTCAGATATCCTATAATTCATAAGGGGTCTAGATCAACAA
TCAAAGACAATATCAATGACAAACTGACGGAAAAGGAGAGAGAGTTTCCACTGTATCCAAAAGGAGGGGAGAAGTTGCAGTTTGATTATG
GTGTCTATCTTCTGAACAAAAATATAGCACAGCTAAGATATCAACATGGACTAGGGACTCCAGACTTGCGGCAAACCCTTCCCAACCTGA
AAAACTTCATGGAGCATGGACTAATGGTCAGGTGTGACAGACATCACACCTCCAGTGCAATCCCTGTTCCTAAGAGACAAAGCTCCATAT
TTGGGGGTGCAGATGTAGGCTTCTCTGGGGGGATCCCTTCACCAGACAAAGGACATCGAAAACGGGCCAGCTCTGAGAATGAGAGACTTC
AGTACAAAACCCCTCCTCCCAGTTACAACTCAGCATTAGCCCAGCCTGTGACCACCGTCCCCTCCATGGGAGAGACCGAGAGAAAGATAA
CATCTCTATCCTCCTCCTTGGATACCTCCTTGGACTTCTCCAAAGAAAACAAGAAAAAAGGAGAGGATCTAGTTGGCAGCTTAAACGGAG
GCCACGCGAATGTGCACCCTAGCCAAGAACAAGGAGAAGCCCTCTCCGGGCACCGGGCCACAGTCAATGGCACTCTCCTACCCAGCGAGC
AGGCCGGGTCCGCCAGTGTCCAGCTTCCAGGCGAGTTCCACCCAGTCTCAGAAGCTGAGCTCTGCTGTACTGTGGAGCAAGCAGAAGAAA
TCATCGGGCTGGAAGCCACAGGTTTCGCCTCAGGTGATCAGCTAGAAGCATTTAACTGCATCCCAGTGGACAGTGCTGTGGCAGTAGAGT
GTGACGAACAAGTTCTGGGAGAATTTGAAGAGTTCTCCCGAAGGATCTATGCACTGAATGAAAACGTATCCAGCTTCCGCCGGCCGCGCA
GGAGTTCCGATAAGTGAAGTGAGCAGGTCAACAGTAGGACTGGGGCAGAAGCTCTGCCTAAAATGAAGTGAAAGCTGCACTTAACCCTTT
GTGATAATGATGACACAAAATGAATATTAATGGAGGATATTCCTCGGAAAAACAGACTTTGGGAATGAAGGAGGGACTCAGGATCATTGT
TATCAGTGGGCCAAAGTTAGATTTTGCTTTCAAGATTTGCTTTTCGGGCCTGATGATTTTAAAGCAAAAATCACCCTCTAGTTGAAAGAG
CTTACAGCTCGAGTCACCTTTTAGCTATTTGTCTGCTTTTTATTTACCCTTGTATGTTATCCTCAGAGGGAAGATGATAATATATAAATA

>66892_66892_2_POLB-UVRAG_POLB_chr8_42202537_ENST00000265421_UVRAG_chr11_75719850_ENST00000528420_length(amino acids)=428AA_BP=62
MSKRKAPQETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLNEHKDYFVCGVKLPNSEDFQAKDDGSIA
VALGYTAHLVSMISFFLQVPLRYPIIHKGSRSTIKDNINDKLTEKEREFPLYPKGGEKLQFDYGVYLLNKNIAQLRYQHGLGTPDLRQTL
PNLKNFMEHGLMVRCDRHHTSSAIPVPKRQSSIFGGADVGFSGGIPSPDKGHRKRASSENERLQYKTPPPSYNSALAQPVTTVPSMGETE
RKITSLSSSLDTSLDFSKENKKKGEDLVGSLNGGHANVHPSQEQGEALSGHRATVNGTLLPSEQAGSASVQLPGEFHPVSEAELCCTVEQ

--------------------------------------------------------------
>66892_66892_3_POLB-UVRAG_POLB_chr8_42202537_ENST00000265421_UVRAG_chr11_75719851_ENST00000356136_length(transcript)=3239nt_BP=356nt
AACAAGCGCCGTGCGCCCCGCCCCCCATCGGGGGCAACCATTGTTCCGCCGGTCGCGCCGGAGCTGGGTTGCTCCTGCTCCCGTCTCCAA
GTCCTGGTACCTCCTTCAAGCTGGGAGAGGGCTCTAGTCCCTGGTTCTGAACACTCTGGGGTTCTCGGGTGCAGGCCGCCATGAGCAAAC
GGAAGGCGCCGCAGGAGACTCTCAACGGGGGAATCACCGACATGCTCACAGAACTCGCAAACTTTGAGAAGAACGTGAGCCAAGCTATCC
ACAAGTACAATGCTTACAGAAAAGCAGCATCTGTTATAGCAAAATACCCACACAAAATAAAGAGTGGAGCTGAAGCTAAGAAATTGAATG
AACATAAGGATTACTTTGTATGCGGTGTCAAGTTGCCTAATTCTGAGGACTTCCAAGCAAAAGATGATGGAAGCATTGCTGTTGCCCTTG
GTTATACTGCACATCTGGTCTCCATGATTTCCTTTTTCCTACAAGTGCCCCTCAGATATCCTATAATTCATAAGGGGTCTAGATCAACAA
TCAAAGACAATATCAATGACAAACTGACGGAAAAGGAGAGAGAGTTTCCACTGTATCCAAAAGGAGGGGAGAAGTTGCAGTTTGATTATG
GTGTCTATCTTCTGAACAAAAATATAGCACAGCTAAGATATCAACATGGACTAGGGACTCCAGACTTGCGGCAAACCCTTCCCAACCTGA
AAAACTTCATGGAGCATGGACTAATGGTCAGGTGTGACAGACATCACACCTCCAGTGCAATCCCTGTTCCTAAGAGACAAAGCTCCATAT
TTGGGGGTGCAGATGTAGGCTTCTCTGGGGGGATCCCTTCACCAGACAAAGGACATCGAAAACGGGCCAGCTCTGAGAATGAGAGACTTC
AGTACAAAACCCCTCCTCCCAGTTACAACTCAGCATTAGCCCAGCCTGTGACCACCGTCCCCTCCATGGGAGAGACCGAGAGAAAGATAA
CATCTCTATCCTCCTCCTTGGATACCTCCTTGGACTTCTCCAAAGAAAACAAGAAAAAAGGAGAGGATCTAGTTGGCAGCTTAAACGGAG
GCCACGCGAATGTGCACCCTAGCCAAGAACAAGGAGAAGCCCTCTCCGGGCACCGGGCCACAGTCAATGGCACTCTCCTACCCAGCGAGC
AGGCCGGGTCCGCCAGTGTCCAGCTTCCAGGCGAGTTCCACCCAGTCTCAGAAGCTGAGCTCTGCTGTACTGTGGAGCAAGCAGAAGAAA
TCATCGGGCTGGAAGCCACAGGTTTCGCCTCAGGTGATCAGCTAGAAGCATTTAACTGCATCCCAGTGGACAGTGCTGTGGCAGTAGAGT
GTGACGAACAAGTTCTGGGAGAATTTGAAGAGTTCTCCCGAAGGATCTATGCACTGAATGAAAACGTATCCAGCTTCCGCCGGCCGCGCA
GGAGTTCCGATAAGTGAAGTGAGCAGGTCAACAGTAGGACTGGGGCAGAAGCTCTGCCTAAAATGAAGTGAAAGCTGCACTTAACCCTTT
GTGATAATGATGACACAAAATGAATATTAATGGAGGATATTCCTCGGAAAAACAGACTTTGGGAATGAAGGAGGGACTCAGGATCATTGT
TATCAGTGGGCCAAAGTTAGATTTTGCTTTCAAGATTTGCTTTTCGGGCCTGATGATTTTAAAGCAAAAATCACCCTCTAGTTGAAAGAG
CTTACAGCTCGAGTCACCTTTTAGCTATTTGTCTGCTTTTTATTTACCCTTGTATGTTATCCTCAGAGGGAAGATGATAATATATAAATA
ATATAATGAACACACCCTTAGTTTCTCATAAGCATTTGCCCTCACCATGGTTTATAAAACTTTGGGAAAACGGAATATTCAGAAATAGGT
TTCCGCCATGTACTGAAAGGTCTGTGGCCATCTGTGAGGTAGATGAAGAAGCAGCATAGTGGTCTCCTTACATCTAGGCCTAACTGTCCC
TCTTCCTGCCCCCGGGTACCACAGTCCACCTTTAGACCCTACTGTCGCCCCATCTTCTCCGTGGATGGGCCATGCGTCCTGAAAACAGGA
CATCAGATTCACTGGTTCTGTAACCCAGTAGCTGTGACGTTCCATCTCTTCTAACCAGCCATGGCCTTCCCCTCCTCTGCCATACCCTTA
ATGCGGCCCTCAGATTAGATGAAAAACTTGCTCCTGGTGGATCCCAAGGGACCCTCAAGGACCTCGAGGTTACTGCAGTCAGATGCCATC
TCATCCCCTGTGGGGGCCAAAGTTTTTATGTGGGCAGATGCTGTGGTCAGGAACTAGGCATGCTTTCTGGCAATGCACTCACCAGACAAA
AATCCCTTGATGTAAATCCCATGTTAATTTATTAAATTTCAGTCAGAAGGTCAGCATTTACATGACAGAATGTATGTAGAGAGTTGGGGT
GTCTGGTAGGCAAACTGCAAGGCAGTTGAGATAGTTGGATTAAGAGGCTAGACGAGACATAGAATACTATTGGTATGTGTGCAATTTCAT
GAATATTAAATTATGTTTCGAAGTCCAGTTGTCATTCCCGCATTCAGATTTCATTTGCTGTTGCTTTATACGTTACGTACCCAAGGACAT
TGCCTCAGGGTTGCAAACTCTTTAAAGGAAAATTTATCCATATATCCATGTATTATATAGAAGAATAAAAATTGAGTTTACTTCACCCGA
CCTGATTTTTTTTTACCAGCTTGGAAATTCCTCTTGAACCTACGTCTCCATATGTCACATCATGACAGGACTAGCCTGAACAAAAGCCAT
GTCTATCTAAGCGGAGGCTGTTGACTTCATTCAGTTTGCATATTGTATATAGCAACACAAACACTTGACAGGTATATACTCCAGTCGCCA
CATTTGTCCTGCATAACAGCTTCACTCACAGGCCTCACCGTCACTTTATTTTGTGTCCAAGCATTCCTGGGCTCAAGTTTAATGTATAGC
TACATTGTTGTTTTCCATGTAGAGAACTCACAGGATGACTACATCACAAATAAACCCAACTCTCAGGCAGTCGAAAGCTTTAACTGGATC
TGCAGAAGCCCATCTTCCTCCACATGAAGAAGTGGGGCTCCTTCACCTAGAGCAGGAGCTTCTCTGCAGTGTACTGTCTGTCGCTCATTT

>66892_66892_3_POLB-UVRAG_POLB_chr8_42202537_ENST00000265421_UVRAG_chr11_75719851_ENST00000356136_length(amino acids)=428AA_BP=62
MSKRKAPQETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLNEHKDYFVCGVKLPNSEDFQAKDDGSIA
VALGYTAHLVSMISFFLQVPLRYPIIHKGSRSTIKDNINDKLTEKEREFPLYPKGGEKLQFDYGVYLLNKNIAQLRYQHGLGTPDLRQTL
PNLKNFMEHGLMVRCDRHHTSSAIPVPKRQSSIFGGADVGFSGGIPSPDKGHRKRASSENERLQYKTPPPSYNSALAQPVTTVPSMGETE
RKITSLSSSLDTSLDFSKENKKKGEDLVGSLNGGHANVHPSQEQGEALSGHRATVNGTLLPSEQAGSASVQLPGEFHPVSEAELCCTVEQ

--------------------------------------------------------------
>66892_66892_4_POLB-UVRAG_POLB_chr8_42202537_ENST00000265421_UVRAG_chr11_75719851_ENST00000528420_length(transcript)=1838nt_BP=356nt
AACAAGCGCCGTGCGCCCCGCCCCCCATCGGGGGCAACCATTGTTCCGCCGGTCGCGCCGGAGCTGGGTTGCTCCTGCTCCCGTCTCCAA
GTCCTGGTACCTCCTTCAAGCTGGGAGAGGGCTCTAGTCCCTGGTTCTGAACACTCTGGGGTTCTCGGGTGCAGGCCGCCATGAGCAAAC
GGAAGGCGCCGCAGGAGACTCTCAACGGGGGAATCACCGACATGCTCACAGAACTCGCAAACTTTGAGAAGAACGTGAGCCAAGCTATCC
ACAAGTACAATGCTTACAGAAAAGCAGCATCTGTTATAGCAAAATACCCACACAAAATAAAGAGTGGAGCTGAAGCTAAGAAATTGAATG
AACATAAGGATTACTTTGTATGCGGTGTCAAGTTGCCTAATTCTGAGGACTTCCAAGCAAAAGATGATGGAAGCATTGCTGTTGCCCTTG
GTTATACTGCACATCTGGTCTCCATGATTTCCTTTTTCCTACAAGTGCCCCTCAGATATCCTATAATTCATAAGGGGTCTAGATCAACAA
TCAAAGACAATATCAATGACAAACTGACGGAAAAGGAGAGAGAGTTTCCACTGTATCCAAAAGGAGGGGAGAAGTTGCAGTTTGATTATG
GTGTCTATCTTCTGAACAAAAATATAGCACAGCTAAGATATCAACATGGACTAGGGACTCCAGACTTGCGGCAAACCCTTCCCAACCTGA
AAAACTTCATGGAGCATGGACTAATGGTCAGGTGTGACAGACATCACACCTCCAGTGCAATCCCTGTTCCTAAGAGACAAAGCTCCATAT
TTGGGGGTGCAGATGTAGGCTTCTCTGGGGGGATCCCTTCACCAGACAAAGGACATCGAAAACGGGCCAGCTCTGAGAATGAGAGACTTC
AGTACAAAACCCCTCCTCCCAGTTACAACTCAGCATTAGCCCAGCCTGTGACCACCGTCCCCTCCATGGGAGAGACCGAGAGAAAGATAA
CATCTCTATCCTCCTCCTTGGATACCTCCTTGGACTTCTCCAAAGAAAACAAGAAAAAAGGAGAGGATCTAGTTGGCAGCTTAAACGGAG
GCCACGCGAATGTGCACCCTAGCCAAGAACAAGGAGAAGCCCTCTCCGGGCACCGGGCCACAGTCAATGGCACTCTCCTACCCAGCGAGC
AGGCCGGGTCCGCCAGTGTCCAGCTTCCAGGCGAGTTCCACCCAGTCTCAGAAGCTGAGCTCTGCTGTACTGTGGAGCAAGCAGAAGAAA
TCATCGGGCTGGAAGCCACAGGTTTCGCCTCAGGTGATCAGCTAGAAGCATTTAACTGCATCCCAGTGGACAGTGCTGTGGCAGTAGAGT
GTGACGAACAAGTTCTGGGAGAATTTGAAGAGTTCTCCCGAAGGATCTATGCACTGAATGAAAACGTATCCAGCTTCCGCCGGCCGCGCA
GGAGTTCCGATAAGTGAAGTGAGCAGGTCAACAGTAGGACTGGGGCAGAAGCTCTGCCTAAAATGAAGTGAAAGCTGCACTTAACCCTTT
GTGATAATGATGACACAAAATGAATATTAATGGAGGATATTCCTCGGAAAAACAGACTTTGGGAATGAAGGAGGGACTCAGGATCATTGT
TATCAGTGGGCCAAAGTTAGATTTTGCTTTCAAGATTTGCTTTTCGGGCCTGATGATTTTAAAGCAAAAATCACCCTCTAGTTGAAAGAG
CTTACAGCTCGAGTCACCTTTTAGCTATTTGTCTGCTTTTTATTTACCCTTGTATGTTATCCTCAGAGGGAAGATGATAATATATAAATA

>66892_66892_4_POLB-UVRAG_POLB_chr8_42202537_ENST00000265421_UVRAG_chr11_75719851_ENST00000528420_length(amino acids)=428AA_BP=62
MSKRKAPQETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLNEHKDYFVCGVKLPNSEDFQAKDDGSIA
VALGYTAHLVSMISFFLQVPLRYPIIHKGSRSTIKDNINDKLTEKEREFPLYPKGGEKLQFDYGVYLLNKNIAQLRYQHGLGTPDLRQTL
PNLKNFMEHGLMVRCDRHHTSSAIPVPKRQSSIFGGADVGFSGGIPSPDKGHRKRASSENERLQYKTPPPSYNSALAQPVTTVPSMGETE
RKITSLSSSLDTSLDFSKENKKKGEDLVGSLNGGHANVHPSQEQGEALSGHRATVNGTLLPSEQAGSASVQLPGEFHPVSEAELCCTVEQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for POLB-UVRAG


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for POLB-UVRAG


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for POLB-UVRAG


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource