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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:POLD3-RNF169 (FusionGDB2 ID:66901)

Fusion Gene Summary for POLD3-RNF169

check button Fusion gene summary
Fusion gene informationFusion gene name: POLD3-RNF169
Fusion gene ID: 66901
HgeneTgene
Gene symbol

POLD3

RNF169

Gene ID

10714

254225

Gene nameDNA polymerase delta 3, accessory subunitring finger protein 169
SynonymsP66|P68|PPP1R128-
Cytomap

11q13.4

11q13.4

Type of geneprotein-codingprotein-coding
DescriptionDNA polymerase delta subunit 3DNA polymerase delta subunit CDNA polymerase delta subunit p66DNA polymerase delta subunit p68Pol delta C subunit (p66)polymerase (DNA) delta 3, accessory subunitpolymerase (DNA-directed), delta 3, accessory subunitproE3 ubiquitin-protein ligase RNF169RING-type E3 ubiquitin transferase RNF169
Modification date2020032220200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000263681, ENST00000527458, 
ENST00000532497, ENST00000532784, 
ENST00000299563, 
Fusion gene scores* DoF score7 X 6 X 6=25210 X 8 X 5=400
# samples 813
** MAII scorelog2(8/252*10)=-1.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/400*10)=-1.62148837674627
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: POLD3 [Title/Abstract] AND RNF169 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRNF169(74528759)-POLD3(74379822), # samples:4
POLD3(74347320)-RNF169(74500671), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePOLD3

GO:0071897

DNA biosynthetic process

11595739

TgeneRNF169

GO:0006974

cellular response to DNA damage stimulus

22733822

TgeneRNF169

GO:2000780

negative regulation of double-strand break repair

22742833


check buttonFusion gene breakpoints across POLD3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RNF169 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A7-A26F-01BPOLD3chr11

74347320

+RNF169chr11

74500671

+
ChimerDB4ESCATCGA-VR-A8ERPOLD3chr11

74347320

+RNF169chr11

74500670

+
ChimerDB4GBMTCGA-06-0174-01APOLD3chr11

74347320

+RNF169chr11

74500671

+
ChimerDB4STADTCGA-CD-8527-01APOLD3chr11

74347320

+RNF169chr11

74500671

+


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Fusion Gene ORF analysis for POLD3-RNF169

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000263681ENST00000299563POLD3chr11

74347320

+RNF169chr11

74500671

+
In-frameENST00000263681ENST00000299563POLD3chr11

74347320

+RNF169chr11

74500670

+
In-frameENST00000527458ENST00000299563POLD3chr11

74347320

+RNF169chr11

74500671

+
In-frameENST00000527458ENST00000299563POLD3chr11

74347320

+RNF169chr11

74500670

+
In-frameENST00000532497ENST00000299563POLD3chr11

74347320

+RNF169chr11

74500671

+
In-frameENST00000532497ENST00000299563POLD3chr11

74347320

+RNF169chr11

74500670

+
intron-3CDSENST00000532784ENST00000299563POLD3chr11

74347320

+RNF169chr11

74500671

+
intron-3CDSENST00000532784ENST00000299563POLD3chr11

74347320

+RNF169chr11

74500670

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000263681POLD3chr1174347320+ENST00000299563RNF169chr1174500670+863513271292951940
ENST00000527458POLD3chr1174347320+ENST00000299563RNF169chr1174500670+8879157115731951012
ENST00000532497POLD3chr1174347320+ENST00000299563RNF169chr1174500670+845711492032773856
ENST00000263681POLD3chr1174347320+ENST00000299563RNF169chr1174500671+863513271292951940
ENST00000527458POLD3chr1174347320+ENST00000299563RNF169chr1174500671+8879157115731951012
ENST00000532497POLD3chr1174347320+ENST00000299563RNF169chr1174500671+845711492032773856

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000263681ENST00000299563POLD3chr1174347320+RNF169chr1174500670+0.0003224580.99967754
ENST00000527458ENST00000299563POLD3chr1174347320+RNF169chr1174500670+0.0003149110.99968517
ENST00000532497ENST00000299563POLD3chr1174347320+RNF169chr1174500670+0.0007498580.9992501
ENST00000263681ENST00000299563POLD3chr1174347320+RNF169chr1174500671+0.0003224580.99967754
ENST00000527458ENST00000299563POLD3chr1174347320+RNF169chr1174500671+0.0003149110.99968517
ENST00000532497ENST00000299563POLD3chr1174347320+RNF169chr1174500671+0.0007498580.9992501

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Fusion Genomic Features for POLD3-RNF169


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
POLD3chr1174347320+RNF169chr1174500670+0.000556460.9994435
POLD3chr1174347320+RNF169chr1174500670+0.000556460.9994435
POLD3chr1174347320+RNF169chr1174500670+0.000556460.9994435
POLD3chr1174347320+RNF169chr1174500670+0.000556460.9994435
POLD3chr1174347320+RNF169chr1174500670+0.000556460.9994435
POLD3chr1174347320+RNF169chr1174500670+0.000556460.9994435

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for POLD3-RNF169


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:74528759/chr11:74379822)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRNF169chr11:74347320chr11:74500670ENST0000029956306205_213167709.0MotifNote=UMI motif
TgeneRNF169chr11:74347320chr11:74500670ENST0000029956306665_682167709.0MotifNote=MIU motif
TgeneRNF169chr11:74347320chr11:74500670ENST0000029956306689_701167709.0MotifNote=LR motif
TgeneRNF169chr11:74347320chr11:74500671ENST0000029956306205_213167709.0MotifNote=UMI motif
TgeneRNF169chr11:74347320chr11:74500671ENST0000029956306665_682167709.0MotifNote=MIU motif
TgeneRNF169chr11:74347320chr11:74500671ENST0000029956306689_701167709.0MotifNote=LR motif

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePOLD3chr11:74347320chr11:74500670ENST00000263681+1112456_463399467.0MotifPIP-box
HgenePOLD3chr11:74347320chr11:74500671ENST00000263681+1112456_463399467.0MotifPIP-box
TgeneRNF169chr11:74347320chr11:74500670ENST000002995630668_107167709.0Zinc fingerRING-type
TgeneRNF169chr11:74347320chr11:74500671ENST000002995630668_107167709.0Zinc fingerRING-type


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Fusion Gene Sequence for POLD3-RNF169


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>66901_66901_1_POLD3-RNF169_POLD3_chr11_74347320_ENST00000263681_RNF169_chr11_74500670_ENST00000299563_length(transcript)=8635nt_BP=1327nt
GTAGTGCGTCGCCTCCGTTGCCGGGGAAACGACCCGGGACCTGGGAGGGAGCAAAGACGTTTCCCGCCGGCGGGAGCTGTGGCTGTGATT
GAGAGAGGGGTTAGAGGCGGGTCCCAGCGCTGCCGCACCATGGCGGACCAGCTTTATCTGGAAAATATAGACGAGTTCGTCACGGACCAA
AACAAGATCGTGACATACAAATGGCTGAGCTATACACTAGGGGTTCATGTTAACCAGGCCAAACAGATGCTGTATGATTATGTTGAAAGG
AAACGAAAAGAAAATTCAGGAGCCCAACTGCATGTTACCTACTTGGTGTCTGGCAGTCTCATTCAGAATGGACATTCCTGCCACAAGGTT
GCAGTAGTGAGAGAAGATAAATTGGAAGCAGTGAAGTCCAAGCTAGCTGTGACTGCCAGCATCCATGTGTACAGCATCCAGAAAGCCATG
CTAAAGGACAGTGGGCCTCTGTTCAATACTGACTATGACATCCTTAAAAGCAACTTGCAGAACTGCAGCAAATTTAGTGCTATACAATGT
GCAGCTGCCGTCCCTAGAGCTCCTGCTGAATCCTCTTCGTCTTCCAAAAAGTTTGAGCAGTCACATCTTCACATGTCAAGTGAGACACAA
GCCAACAATGAGCTGACCACCAATGGTCATGGCCCACCTGCATCCAAGCAGGTTTCCCAGCAGCCCAAAGGAATTATGGGAATGTTTGCC
TCCAAAGCTGCTGCTAAAACCCAAGAAACCAACAAGGAAACGAAAACAGAGGCTAAAGAAGTAACAAATGCATCTGCAGCAGGCAACAAG
GCACCAGGGAAAGGGAATATGATGAGCAACTTTTTTGGAAAAGCTGCTATGAATAAATTTAAAGTCAATTTGGACTCAGAACAAGCAGTG
AAAGAAGAAAAAATAGTGGAGCAGCCTACAGTGTCTGTCACGGAACCAAAGCTGGCAACTCCTGCAGGCCTGAAAAAATCCAGCAAAAAA
GCAGAGCCTGTTAAGGTGCTGCAGAAGGAAAAAAAAAGGGGGAAGCGAGTAGCATTATCTGATGATGAGACAAAGGAAACTGAAAACATG
AGGAAAAAGAGGAGAAGAATCAAACTTCCTGAATCTGATAGCAGTGAAGATGAAGTCTTTCCAGACTCTCCTGGGGCTTATGAAGCTGAG
TCACCATCCCCACCTCCTCCTCCGTCTCCACCTCTTGAACCAGTGCCAAAGACTGAGCCTGAACCTCCTTCTGTCAAGAGCTCAAGTGGA
GAAAACAAAAGAAAACGAAAACGCGTACTAAAATCTAAAACTTACCTGGATGGGGAAGGCTGCATAGACTTTATATTCAGAGCACCAATC
AAATTAAGCAAGCCTGGGGAACTTCGTGAGGAATATGAAAGCTTGAGAAAGCTGAGAGAAGAAAAGTTACAAGAGGAAAAACCCTCTGAA
GATCAAATCCACAAGCTGTTACCAGAGGATACAGAAACAGGGAAAAGGAAAATGGATGAACAGAAAAAAAGAGATGAACCATTAGTACTG
AAAACAAATCTGGAACGTTGTCCTGCACGTCTCTCAGATTCAGAGAATGAAGAACCTTCTCGAGGCCAGATGACACAGACACATCGCTCG
GCATTTGTTTCCAAGAACAACTCCTACTCCTTAGCTTTCCTGGCAGGGAAGCTAAACTCCAAGGTGGAAAGGAGTCAGAGCTGTAGTGAC
ACAGCCCAGGAAAGAGCGAAGAGCAGAGTCAGAGCAGTTCCAGGCAACAAAGCCAAGGTCACAACTATGACTCCAGCCTCCAACCCCATC
ATTGGTGTCCTCTTGTCAACTCAAAACAACCGCTGCGTCTCGGCCCCTGACTTAACCATCGAAAAGCGTCTACCCTTCAGCTCCCTTTCA
TCCTTGGCTTCCCTGCATAAGCCAGAGCGTTCTGTCAGCCCTGAGAGCAATGACAGCATCTCCGAAGAACTAAACCATTTCAAGCCCATT
GTCTGCTCACCATGTACTCCTCCCAAGAGACTCCCTGATGGCCGTGTGCTAAGTCCTCTCATCATCAAATCAACTCCACGCAACCTAAAC
AGAAGCCTGCAGAAGCAGACTTCTTATGAGGCCAGTCCACGGATCCTCAAAAAGTGGGAACAGATCTTTCAGGAGCGGCAGATCAAAAAG
ACCCTTTCAAAAGCCACTCTTACCTCTCTGGCTCCTGAAATGGGGGAAGAGTTACTAGGCTCTGAAGGTATCCATTCTAGCAAGGAGAAG
CCACTTGTGGCTGTAAATACAAGATTATCTGGTGGGCAGGTCCTCTCTGAGTATACTGGACCCACCTCTGCTGATCTTGATCATTTCCCC
TCTGTTAGCCAAACAAAAGCAGAACAGGACAGTGATAATAAAAGTAGCACTGAGATCCCACTGGAAACCTGCTGTTCCTCAGAACTCAAA
GGGGGAGGCAGTGGGACTTCTTTGGAGAGGGAGCAGTTTGAGGGGTTAGGGTCAACTCCAGATGCCAAGTTAGACAAAACCTGTATAAGC
AGAGCCATGAAAATCACCACAGTTAATTCAGTGCTACCCCAAAACAGTGTTTTGGGTGGAGTCCTCAAAACAAAGCAACAATTGAAGACA
TTAAATCATTTTGATCTGACTAATGGTGTTCTAGTTGAGAGCCTAAGTGAAGAGCCACTTCCTTCTTTGCGTCGAGGCCGGAAAAGACAC
TGCAAGACCAAGCACTTAGAACAAAATGGCTCCCTTAAAAAACTGCGACAAACCAGTGGGGAGGTGGGTCTGGCCCCAACAGACCCAGTC
CTGCGAGAGATGGAGCAGAAGCTTCAGCAAGAGGAAGAAGACCGACAGTTGGCTCTGCAGTTGCAGCGCATGTTCGACAATGAGAGGCGG
ACTGTGAGCCGGCGAAAAGGAAGTGTGGATCAGTATCTCCTACGGTCCAGCAACATGGCCGGGGCCAAGTAGCACCTAATGAAGTGTTAC
CTATTTTTAAAAGGTCTTAGGCCTTGATCATTTATCCTGAAGAGCTGAGTGTTCTCACTTTGGTTTTATTTTAATGGCAAAACACTGTCT
AATATGGTTCTGAGAGGTTCCAGGGCCTTTGTAGTCAATATCCAAGGGAAAAGCATCTCCGTTTCTCTGTGACCCAGGCCAGAAGCCTGA
GTGACCCATCCCTAAGGGCTTCTGGGCCAAACCTGGCAGCACCCACTGGGAATGAGATTTGGAACGGCCTCAGGAGCATAATGGCCACAG
TTAGTAATGGTAAAGAGGGGATACCTTCTTAAACTGATAGACTTCCTGACTTCTTTCAGCAGGGTATTGTTTTAAATCAGCCTTGCAGAT
AAAAATTAATTCCATCTTTTTCAGACAAGTGAACAATTTAGTTCCTTGGCAGATCCAAAATGATAGATGGTTATGTTACGCTTTCTGCTG
TCCCTTGCCAAAAATAAGTAAATATATCAGTTAAGATTATGCCTTTACAAAAGTTAATTTACATTCTCTGTTTAAAAAATAATATTTGGT
GAATGCTATATAGTTGACAGAGCACATTTACAGACCTTATTAATTTAGTCTTTCCAAGAGACCTCTCATGTAACTGGCATTAGCCCCATT
TTTAGATGATGAAACTGCAGTGCAGATGTTCTGGTTCTCTCAACTACCAAGTGGCATAACCCATGGATTTTCTAAAGGTTTCCCAAATAG
ATCACAACCTAAGGGTGTGCCAGGGGAGCCTAGGGGAAGCTAGGCTGGGCATTGAACACTGATAGTGCAGAATCCACATGCAAACAAGAT
CGACAGGGTGGATAAACATATATGTGCATTATCCCCATCCCCCACAGTTTAGAGCCTTCTGCTTTTCTGGGGGTTTCAGCCTATGAGACA
AACTATAATCAGGCTTCATTATTACTTTTCAAATGGCCAAGGGTTATCTGCAATGTTGATCTAAAATCCTAAAAAATCACCCTGAAGTCA
GGCAAGGAACAATACTTAAACTCCATACTATGGAAACAAGGTATCTAGCTGGATGCAGCTGGTAAATTCAGTCCCATGGACCTTTGGGGG
TTTATTTTCCTTAGCAGCTGACACCATGTGTCTTTTGCATCCCTGGTGGTGCTTGGTGCTTCTGCCCATCTGGGCTCATTGAGAATAGGG
ATGAAGATATGATTTTAGGGAATTTCTGATGGGCTGGCATGCCCCATGTAGTATGAGTTACTATATAAAGTCATGTGACTGGCATTTTAA
CAGACCTTCCAGAGCTTATATATCCCAATATATGTTGTTTCCTTTGAGTAGCCCCAGCAGGATACTGCTTAGTTTTTCCAGTGCCATTGG
TGAAAGCATTTCTGGAACTGTCTTCAAAGACTAGAAACACTGACTCCCAAAATGCTAGAACTGGAAGGGACCTTAATGGTTATCTATTCC
AGCCTCCTCCTAAGGTCCTCCTCAGCTTCTAGACCTAGAAGCCAAAGTCCAGAACAGTGACCCATTGATCAAGGCAGATAGTATAACTCC
TTTTAAGTGTTCTCAGATTTGCCTTTTCTCAGGGCAAATCTTCAGTGTTTTGTGGTTATTTGTGGTTGAGAGAGAGAGAGAATGTAATGT
CTGAGACTAGCCAGCAGCTATTTGAAGCCTCTGGGAAAGAAGGTGGCTTATCAAGTGGGTTTGTAGTAATGAGTGCTGCTGTAAAGCAGA
GCCATTTTCTTGTGCAGCTCATAGTTCCCAAACAGTTCCCAAACAGAAATTCCAGAGATGTCTTAAACATTGTGGTCATCATTGAGATAG
GTGGAATCTCTTTGGTGACTACGTTGGTGGGGAACATCACTCACCTGAATGTATGCATTCTGTGTTCTCTGTGTGTGTGCACATATGCAG
ATGTATGTTTTAAAAACATTTACCAAACTCATGATTTTGTAGTCACACCACTTCAGTTCTGGGCCCTACCAACAATTTATGTCCTCCAAG
AGCTGCTGGAGGGCATGTTTGTGCCCAAAACAGAAGAGCTGGCTCTGGTTTACAGAAGACAGGGAGGGTGACCTTACTATAAATGCCCTT
AGAGGAAACTTATCAGTTACTGCCATTTCACGCATTTCCTTTTTGATCTTAGTAAATATTATTGGAAGGCTAGTCTTGTTGGTAGGAGCA
AAGACACTTATTTTTCCACTTGCCATCTTTCTCTATATCTCCAGTAATTTGAAAAACACTTTTCAGTTGGAATTGATTTTTGTCTTTGGT
AAAAAGAAATATTTTTAATAGATAAAAGATATATATTTTAAATATTTCCCCAAATTAATACTTTCATTTTAAGAATTGCATAGCAGTTGT
AACAAGTGCAGAATGAAGAACAAATTCTTGTTAAGCAAATAGTCCAAACTCTAGGTCCAGCTTACTGCCTTCCCCCCTTGTACCTACAGT
GATGCCTAGGATGGTATTGACAGTTGTTTTCTAAACTTCCTGCTGAGCAACAGTCCTTCAAATATAGGTAGAGTGGTCTAGGTTAAGGAG
GGAGGAGGGTTGATCTTTAATCAGGTTGGCTTTGGAGGAAGGAAAAACCACTAAGGTATTATCTGAATTTTAAGATGCTTCCCATCCTTA
ATAACTAAAACCTGAATGCTTTTCTTTCTGAAAAATCTCCCTCTCTCCTTCCATGATTCTGAAGTTGGTTAAAAGTCGATATGTTGATGT
GTATTATTTGGGGGAACAGAAAAGGACAAGGAAGGAAACAGAACGATGGGAAGGGTTTGTGAGCTAGAATAAGAGGTGCAGGATTTCACA
AAACAAATTCCTCACAAATCATTGAAGCCCAGTTCACCATACAAATTACCCATGTCTTACTCTGTTCCTTGTATATATGCATTCTGGGTT
TTTTTATTATTAAAGGGGAAGTTAGGGGGGAGGGTGAAGGTCAGTCTGAGGGGAAATCCAGGAAATGTGGTGCCCTTAGAAGGGGGCTGT
CAGCTCTTTTCCATAGAGAGGGAAAGAAACTTTGAGAAAATGTTCTTGACCCATTGATTGTATCTGCTGGAAGAAGTCATCTGGGCCTGT
TGGGTTGGTATCAGATCAGGGGATTATGCATCCAGCCCCTGGCCCCTTTAATCTATTTGCCTCTTTTTAAAAAAGGTTAAGTCTTCTTGG
GTGAGGCTTGCCAGGGAAACTCCTAAGTGGCTTCACTTATTTTTTAAATTTTAATTTAATTTTTAAATTTTTGCTTGGAAGCAGCACTGG
TAATAAATGTTTTATTTTTTGTTCATTTTCCCTAAAGGAAAAATGTCCTTAAGAGATTAAAGCTCTTAATTGATTACTGTCTGGTTACAA
ACTGGCAAACTGACTAAAATGGGAAGCTGCCACCGTGCCTGACTCATGTAGCTGATGACCGAAGGCTCATCCTTTCTTTTCTATTTGACA
GACATTTACTGAGCTTCAGACTTGAGCCAACCCTGAGCTGGACTGTGGAGATAAAGCAGTTCCTGCTCTTGAGGAGCTCAATGTCTAATG
GAATGCATTTGAATGTATGTGTGGCTGGAGAGTTCATTTATGGTCTTAGGAAAGCCATTTCTGGTCCCATTTAGAAAACTGACCAGCACC
CAGCAAGCTGCATTCTACATTTTAGAGACCCCATTGGTATTTGTGAATTTGATTGCACCACCGCTTTTCCTTTACTAAGTAATGTTATGG
AAGGAGAATGAATTTTCTCCTCTAGTGATTACAGGACATTAACATCTCTTCAGAAGCTGCTTTTAGCTTAAGCCCCAAGAAGTGAGGTGG
GTTGTGGATCACTGACATGGTCAGGGGAGGCCCACACCTCAATTCAGTAACCACCTAATCTCTCCCCCAACCTGATCTCTCATCAGAGCT
GGCAGCAACTTGGGATTCCTTTCCTTTTTCCTGCCTAACTTTTCATTGAAATGTCTAGTAGGAGAGTGAGAAAAGAGAACAAAGGCTGGG
TCACAGTCATAGAATGTTACAGCTGGAATGGGCATGGAAATCATCCAAGTTAAACTTCTTCTCTGCCCCCCGCCCCCACTTTTTTTTTTT
TTTTTTTTTAACCAAACGAACTTGTGATCCAGTGCCCTATTTTATAGTGTGGTTTTCCAGGGTCTGAATAAATAATCATTAAAGTTTGAC
ACACGCAGACACACGCACCAATGATGGGGATACCCCCAAATGATTTAGGAGGTTATTTTATTTTAATAGTTTTTTCTTCCTGATTTTTTT
CAGTTAGTTAGAGTTAAATGTACCTATAGCCCCTGAATACATGCTCAGGTAGAGAAAGTCTCCATAGTATAAGTAAGTAATATGAATGTG
GAATCTTGGAAAGTGATATATTTTGATTGGAATAATTTTAATTAAATTTAATGATTTTAATTAAGAATTAAAAGCCAGCTAGCCAAATTT
TCTTTAAAAATTGGAAACTCATTATGGTCTTAAATTGTCCTCAGGCAGCCTTTTCCTCATCAACCCATAGAGTGGTCTTTTGAACTGGTA
TCTAAACATACCTGGTTATGAATTCTCAAAAGAGAAAGCAGGTCTGGGGCGGGGTGGTCAGGAGACAGATTCTAGGGAAAGTGCTGAAGA
GATTTTCTTCTGAAGATGATCTAGGAAATGCATCTTTATACATGATTGTTAGCTGCTGTAGCTTTCTGAAGAAGATTGTAGAAAAGAGAC
TAAGATATATGCAAGGGTCACCAGTTTAGAGATCAGTCAAATTGGAAAAAGTGCCAAGACTGGATGTGCAGATTGTTCTATGTATTATCA
GTATTTTTTTCCTCTTAAGAAAAAAATTTACTCTCTCTCCTTTGTGAGTAAATGCCTCCTTAATGCCTTTTAAGTAAGGTGGCAACTTTT
AACTGTCATCTTGTGAGAGGCAACCTCAAACTCTAAGCAGACTCCCTCTCTCCCTTTCTGGTGTCTTAAATCAAGAACTAGTTTGAAGCC
AAGGCAAAGCAAGGTTTGTTCATCTTCCTTTCCTGTCATTTAAGGTAAAACAGGCAATGAACTCGCTCTTCAAATACCATAGTTCAAGAG
TAGCTGTTGGCCCTGGTTCCAGATTAATATAGCAGCAGGCAGATTGCCCCTTCTTGGGGCCACCACCCTCCAAAGCTGTGCCACCAATGA
GAGCATTGGGTTCAAGTTTGCATCAAACATGGTATTACCAACGCTGAGCCTCCAGCAGAGCACTTAAAAGTCCTAGTGAGAGAATAGATA
CTATGCAAGGGAAAAAAATTTAAATGCCAACGAATAGTTTTTTTTTTTTTGAACCTGATACACTGTTTGTTTACTCTCAACTCTTTGTAC
AAATATTATTGTCCTAAGGGCCTTTTCCCCTCCTGCCTAGAAAATAGGTTGTGTATTGGTTTTATTCAACCTGCTGTCTGCTTTAGGATT
GGAGAAGGTACCTGGATCCTTGTGGACTGCCACTGCTGGCTGCCTCCTCTCCAACTCATCAGAAGAGCATTTTGACAAAGACAGAGGACT
TGGACCAGGGCATGCCCTGTTGGGGATGTTTCTGTCAGCAAGGACATGGCATGGAATCAAGTGGGCTGATGTGTTGTTATTTAAACAGTA

>66901_66901_1_POLD3-RNF169_POLD3_chr11_74347320_ENST00000263681_RNF169_chr11_74500670_ENST00000299563_length(amino acids)=940AA_BP=0
MADQLYLENIDEFVTDQNKIVTYKWLSYTLGVHVNQAKQMLYDYVERKRKENSGAQLHVTYLVSGSLIQNGHSCHKVAVVREDKLEAVKS
KLAVTASIHVYSIQKAMLKDSGPLFNTDYDILKSNLQNCSKFSAIQCAAAVPRAPAESSSSSKKFEQSHLHMSSETQANNELTTNGHGPP
ASKQVSQQPKGIMGMFASKAAAKTQETNKETKTEAKEVTNASAAGNKAPGKGNMMSNFFGKAAMNKFKVNLDSEQAVKEEKIVEQPTVSV
TEPKLATPAGLKKSSKKAEPVKVLQKEKKRGKRVALSDDETKETENMRKKRRRIKLPESDSSEDEVFPDSPGAYEAESPSPPPPPSPPLE
PVPKTEPEPPSVKSSSGENKRKRKRVLKSKTYLDGEGCIDFIFRAPIKLSKPGELREEYESLRKLREEKLQEEKPSEDQIHKLLPEDTET
GKRKMDEQKKRDEPLVLKTNLERCPARLSDSENEEPSRGQMTQTHRSAFVSKNNSYSLAFLAGKLNSKVERSQSCSDTAQERAKSRVRAV
PGNKAKVTTMTPASNPIIGVLLSTQNNRCVSAPDLTIEKRLPFSSLSSLASLHKPERSVSPESNDSISEELNHFKPIVCSPCTPPKRLPD
GRVLSPLIIKSTPRNLNRSLQKQTSYEASPRILKKWEQIFQERQIKKTLSKATLTSLAPEMGEELLGSEGIHSSKEKPLVAVNTRLSGGQ
VLSEYTGPTSADLDHFPSVSQTKAEQDSDNKSSTEIPLETCCSSELKGGGSGTSLEREQFEGLGSTPDAKLDKTCISRAMKITTVNSVLP
QNSVLGGVLKTKQQLKTLNHFDLTNGVLVESLSEEPLPSLRRGRKRHCKTKHLEQNGSLKKLRQTSGEVGLAPTDPVLREMEQKLQQEEE

--------------------------------------------------------------
>66901_66901_2_POLD3-RNF169_POLD3_chr11_74347320_ENST00000263681_RNF169_chr11_74500671_ENST00000299563_length(transcript)=8635nt_BP=1327nt
GTAGTGCGTCGCCTCCGTTGCCGGGGAAACGACCCGGGACCTGGGAGGGAGCAAAGACGTTTCCCGCCGGCGGGAGCTGTGGCTGTGATT
GAGAGAGGGGTTAGAGGCGGGTCCCAGCGCTGCCGCACCATGGCGGACCAGCTTTATCTGGAAAATATAGACGAGTTCGTCACGGACCAA
AACAAGATCGTGACATACAAATGGCTGAGCTATACACTAGGGGTTCATGTTAACCAGGCCAAACAGATGCTGTATGATTATGTTGAAAGG
AAACGAAAAGAAAATTCAGGAGCCCAACTGCATGTTACCTACTTGGTGTCTGGCAGTCTCATTCAGAATGGACATTCCTGCCACAAGGTT
GCAGTAGTGAGAGAAGATAAATTGGAAGCAGTGAAGTCCAAGCTAGCTGTGACTGCCAGCATCCATGTGTACAGCATCCAGAAAGCCATG
CTAAAGGACAGTGGGCCTCTGTTCAATACTGACTATGACATCCTTAAAAGCAACTTGCAGAACTGCAGCAAATTTAGTGCTATACAATGT
GCAGCTGCCGTCCCTAGAGCTCCTGCTGAATCCTCTTCGTCTTCCAAAAAGTTTGAGCAGTCACATCTTCACATGTCAAGTGAGACACAA
GCCAACAATGAGCTGACCACCAATGGTCATGGCCCACCTGCATCCAAGCAGGTTTCCCAGCAGCCCAAAGGAATTATGGGAATGTTTGCC
TCCAAAGCTGCTGCTAAAACCCAAGAAACCAACAAGGAAACGAAAACAGAGGCTAAAGAAGTAACAAATGCATCTGCAGCAGGCAACAAG
GCACCAGGGAAAGGGAATATGATGAGCAACTTTTTTGGAAAAGCTGCTATGAATAAATTTAAAGTCAATTTGGACTCAGAACAAGCAGTG
AAAGAAGAAAAAATAGTGGAGCAGCCTACAGTGTCTGTCACGGAACCAAAGCTGGCAACTCCTGCAGGCCTGAAAAAATCCAGCAAAAAA
GCAGAGCCTGTTAAGGTGCTGCAGAAGGAAAAAAAAAGGGGGAAGCGAGTAGCATTATCTGATGATGAGACAAAGGAAACTGAAAACATG
AGGAAAAAGAGGAGAAGAATCAAACTTCCTGAATCTGATAGCAGTGAAGATGAAGTCTTTCCAGACTCTCCTGGGGCTTATGAAGCTGAG
TCACCATCCCCACCTCCTCCTCCGTCTCCACCTCTTGAACCAGTGCCAAAGACTGAGCCTGAACCTCCTTCTGTCAAGAGCTCAAGTGGA
GAAAACAAAAGAAAACGAAAACGCGTACTAAAATCTAAAACTTACCTGGATGGGGAAGGCTGCATAGACTTTATATTCAGAGCACCAATC
AAATTAAGCAAGCCTGGGGAACTTCGTGAGGAATATGAAAGCTTGAGAAAGCTGAGAGAAGAAAAGTTACAAGAGGAAAAACCCTCTGAA
GATCAAATCCACAAGCTGTTACCAGAGGATACAGAAACAGGGAAAAGGAAAATGGATGAACAGAAAAAAAGAGATGAACCATTAGTACTG
AAAACAAATCTGGAACGTTGTCCTGCACGTCTCTCAGATTCAGAGAATGAAGAACCTTCTCGAGGCCAGATGACACAGACACATCGCTCG
GCATTTGTTTCCAAGAACAACTCCTACTCCTTAGCTTTCCTGGCAGGGAAGCTAAACTCCAAGGTGGAAAGGAGTCAGAGCTGTAGTGAC
ACAGCCCAGGAAAGAGCGAAGAGCAGAGTCAGAGCAGTTCCAGGCAACAAAGCCAAGGTCACAACTATGACTCCAGCCTCCAACCCCATC
ATTGGTGTCCTCTTGTCAACTCAAAACAACCGCTGCGTCTCGGCCCCTGACTTAACCATCGAAAAGCGTCTACCCTTCAGCTCCCTTTCA
TCCTTGGCTTCCCTGCATAAGCCAGAGCGTTCTGTCAGCCCTGAGAGCAATGACAGCATCTCCGAAGAACTAAACCATTTCAAGCCCATT
GTCTGCTCACCATGTACTCCTCCCAAGAGACTCCCTGATGGCCGTGTGCTAAGTCCTCTCATCATCAAATCAACTCCACGCAACCTAAAC
AGAAGCCTGCAGAAGCAGACTTCTTATGAGGCCAGTCCACGGATCCTCAAAAAGTGGGAACAGATCTTTCAGGAGCGGCAGATCAAAAAG
ACCCTTTCAAAAGCCACTCTTACCTCTCTGGCTCCTGAAATGGGGGAAGAGTTACTAGGCTCTGAAGGTATCCATTCTAGCAAGGAGAAG
CCACTTGTGGCTGTAAATACAAGATTATCTGGTGGGCAGGTCCTCTCTGAGTATACTGGACCCACCTCTGCTGATCTTGATCATTTCCCC
TCTGTTAGCCAAACAAAAGCAGAACAGGACAGTGATAATAAAAGTAGCACTGAGATCCCACTGGAAACCTGCTGTTCCTCAGAACTCAAA
GGGGGAGGCAGTGGGACTTCTTTGGAGAGGGAGCAGTTTGAGGGGTTAGGGTCAACTCCAGATGCCAAGTTAGACAAAACCTGTATAAGC
AGAGCCATGAAAATCACCACAGTTAATTCAGTGCTACCCCAAAACAGTGTTTTGGGTGGAGTCCTCAAAACAAAGCAACAATTGAAGACA
TTAAATCATTTTGATCTGACTAATGGTGTTCTAGTTGAGAGCCTAAGTGAAGAGCCACTTCCTTCTTTGCGTCGAGGCCGGAAAAGACAC
TGCAAGACCAAGCACTTAGAACAAAATGGCTCCCTTAAAAAACTGCGACAAACCAGTGGGGAGGTGGGTCTGGCCCCAACAGACCCAGTC
CTGCGAGAGATGGAGCAGAAGCTTCAGCAAGAGGAAGAAGACCGACAGTTGGCTCTGCAGTTGCAGCGCATGTTCGACAATGAGAGGCGG
ACTGTGAGCCGGCGAAAAGGAAGTGTGGATCAGTATCTCCTACGGTCCAGCAACATGGCCGGGGCCAAGTAGCACCTAATGAAGTGTTAC
CTATTTTTAAAAGGTCTTAGGCCTTGATCATTTATCCTGAAGAGCTGAGTGTTCTCACTTTGGTTTTATTTTAATGGCAAAACACTGTCT
AATATGGTTCTGAGAGGTTCCAGGGCCTTTGTAGTCAATATCCAAGGGAAAAGCATCTCCGTTTCTCTGTGACCCAGGCCAGAAGCCTGA
GTGACCCATCCCTAAGGGCTTCTGGGCCAAACCTGGCAGCACCCACTGGGAATGAGATTTGGAACGGCCTCAGGAGCATAATGGCCACAG
TTAGTAATGGTAAAGAGGGGATACCTTCTTAAACTGATAGACTTCCTGACTTCTTTCAGCAGGGTATTGTTTTAAATCAGCCTTGCAGAT
AAAAATTAATTCCATCTTTTTCAGACAAGTGAACAATTTAGTTCCTTGGCAGATCCAAAATGATAGATGGTTATGTTACGCTTTCTGCTG
TCCCTTGCCAAAAATAAGTAAATATATCAGTTAAGATTATGCCTTTACAAAAGTTAATTTACATTCTCTGTTTAAAAAATAATATTTGGT
GAATGCTATATAGTTGACAGAGCACATTTACAGACCTTATTAATTTAGTCTTTCCAAGAGACCTCTCATGTAACTGGCATTAGCCCCATT
TTTAGATGATGAAACTGCAGTGCAGATGTTCTGGTTCTCTCAACTACCAAGTGGCATAACCCATGGATTTTCTAAAGGTTTCCCAAATAG
ATCACAACCTAAGGGTGTGCCAGGGGAGCCTAGGGGAAGCTAGGCTGGGCATTGAACACTGATAGTGCAGAATCCACATGCAAACAAGAT
CGACAGGGTGGATAAACATATATGTGCATTATCCCCATCCCCCACAGTTTAGAGCCTTCTGCTTTTCTGGGGGTTTCAGCCTATGAGACA
AACTATAATCAGGCTTCATTATTACTTTTCAAATGGCCAAGGGTTATCTGCAATGTTGATCTAAAATCCTAAAAAATCACCCTGAAGTCA
GGCAAGGAACAATACTTAAACTCCATACTATGGAAACAAGGTATCTAGCTGGATGCAGCTGGTAAATTCAGTCCCATGGACCTTTGGGGG
TTTATTTTCCTTAGCAGCTGACACCATGTGTCTTTTGCATCCCTGGTGGTGCTTGGTGCTTCTGCCCATCTGGGCTCATTGAGAATAGGG
ATGAAGATATGATTTTAGGGAATTTCTGATGGGCTGGCATGCCCCATGTAGTATGAGTTACTATATAAAGTCATGTGACTGGCATTTTAA
CAGACCTTCCAGAGCTTATATATCCCAATATATGTTGTTTCCTTTGAGTAGCCCCAGCAGGATACTGCTTAGTTTTTCCAGTGCCATTGG
TGAAAGCATTTCTGGAACTGTCTTCAAAGACTAGAAACACTGACTCCCAAAATGCTAGAACTGGAAGGGACCTTAATGGTTATCTATTCC
AGCCTCCTCCTAAGGTCCTCCTCAGCTTCTAGACCTAGAAGCCAAAGTCCAGAACAGTGACCCATTGATCAAGGCAGATAGTATAACTCC
TTTTAAGTGTTCTCAGATTTGCCTTTTCTCAGGGCAAATCTTCAGTGTTTTGTGGTTATTTGTGGTTGAGAGAGAGAGAGAATGTAATGT
CTGAGACTAGCCAGCAGCTATTTGAAGCCTCTGGGAAAGAAGGTGGCTTATCAAGTGGGTTTGTAGTAATGAGTGCTGCTGTAAAGCAGA
GCCATTTTCTTGTGCAGCTCATAGTTCCCAAACAGTTCCCAAACAGAAATTCCAGAGATGTCTTAAACATTGTGGTCATCATTGAGATAG
GTGGAATCTCTTTGGTGACTACGTTGGTGGGGAACATCACTCACCTGAATGTATGCATTCTGTGTTCTCTGTGTGTGTGCACATATGCAG
ATGTATGTTTTAAAAACATTTACCAAACTCATGATTTTGTAGTCACACCACTTCAGTTCTGGGCCCTACCAACAATTTATGTCCTCCAAG
AGCTGCTGGAGGGCATGTTTGTGCCCAAAACAGAAGAGCTGGCTCTGGTTTACAGAAGACAGGGAGGGTGACCTTACTATAAATGCCCTT
AGAGGAAACTTATCAGTTACTGCCATTTCACGCATTTCCTTTTTGATCTTAGTAAATATTATTGGAAGGCTAGTCTTGTTGGTAGGAGCA
AAGACACTTATTTTTCCACTTGCCATCTTTCTCTATATCTCCAGTAATTTGAAAAACACTTTTCAGTTGGAATTGATTTTTGTCTTTGGT
AAAAAGAAATATTTTTAATAGATAAAAGATATATATTTTAAATATTTCCCCAAATTAATACTTTCATTTTAAGAATTGCATAGCAGTTGT
AACAAGTGCAGAATGAAGAACAAATTCTTGTTAAGCAAATAGTCCAAACTCTAGGTCCAGCTTACTGCCTTCCCCCCTTGTACCTACAGT
GATGCCTAGGATGGTATTGACAGTTGTTTTCTAAACTTCCTGCTGAGCAACAGTCCTTCAAATATAGGTAGAGTGGTCTAGGTTAAGGAG
GGAGGAGGGTTGATCTTTAATCAGGTTGGCTTTGGAGGAAGGAAAAACCACTAAGGTATTATCTGAATTTTAAGATGCTTCCCATCCTTA
ATAACTAAAACCTGAATGCTTTTCTTTCTGAAAAATCTCCCTCTCTCCTTCCATGATTCTGAAGTTGGTTAAAAGTCGATATGTTGATGT
GTATTATTTGGGGGAACAGAAAAGGACAAGGAAGGAAACAGAACGATGGGAAGGGTTTGTGAGCTAGAATAAGAGGTGCAGGATTTCACA
AAACAAATTCCTCACAAATCATTGAAGCCCAGTTCACCATACAAATTACCCATGTCTTACTCTGTTCCTTGTATATATGCATTCTGGGTT
TTTTTATTATTAAAGGGGAAGTTAGGGGGGAGGGTGAAGGTCAGTCTGAGGGGAAATCCAGGAAATGTGGTGCCCTTAGAAGGGGGCTGT
CAGCTCTTTTCCATAGAGAGGGAAAGAAACTTTGAGAAAATGTTCTTGACCCATTGATTGTATCTGCTGGAAGAAGTCATCTGGGCCTGT
TGGGTTGGTATCAGATCAGGGGATTATGCATCCAGCCCCTGGCCCCTTTAATCTATTTGCCTCTTTTTAAAAAAGGTTAAGTCTTCTTGG
GTGAGGCTTGCCAGGGAAACTCCTAAGTGGCTTCACTTATTTTTTAAATTTTAATTTAATTTTTAAATTTTTGCTTGGAAGCAGCACTGG
TAATAAATGTTTTATTTTTTGTTCATTTTCCCTAAAGGAAAAATGTCCTTAAGAGATTAAAGCTCTTAATTGATTACTGTCTGGTTACAA
ACTGGCAAACTGACTAAAATGGGAAGCTGCCACCGTGCCTGACTCATGTAGCTGATGACCGAAGGCTCATCCTTTCTTTTCTATTTGACA
GACATTTACTGAGCTTCAGACTTGAGCCAACCCTGAGCTGGACTGTGGAGATAAAGCAGTTCCTGCTCTTGAGGAGCTCAATGTCTAATG
GAATGCATTTGAATGTATGTGTGGCTGGAGAGTTCATTTATGGTCTTAGGAAAGCCATTTCTGGTCCCATTTAGAAAACTGACCAGCACC
CAGCAAGCTGCATTCTACATTTTAGAGACCCCATTGGTATTTGTGAATTTGATTGCACCACCGCTTTTCCTTTACTAAGTAATGTTATGG
AAGGAGAATGAATTTTCTCCTCTAGTGATTACAGGACATTAACATCTCTTCAGAAGCTGCTTTTAGCTTAAGCCCCAAGAAGTGAGGTGG
GTTGTGGATCACTGACATGGTCAGGGGAGGCCCACACCTCAATTCAGTAACCACCTAATCTCTCCCCCAACCTGATCTCTCATCAGAGCT
GGCAGCAACTTGGGATTCCTTTCCTTTTTCCTGCCTAACTTTTCATTGAAATGTCTAGTAGGAGAGTGAGAAAAGAGAACAAAGGCTGGG
TCACAGTCATAGAATGTTACAGCTGGAATGGGCATGGAAATCATCCAAGTTAAACTTCTTCTCTGCCCCCCGCCCCCACTTTTTTTTTTT
TTTTTTTTTAACCAAACGAACTTGTGATCCAGTGCCCTATTTTATAGTGTGGTTTTCCAGGGTCTGAATAAATAATCATTAAAGTTTGAC
ACACGCAGACACACGCACCAATGATGGGGATACCCCCAAATGATTTAGGAGGTTATTTTATTTTAATAGTTTTTTCTTCCTGATTTTTTT
CAGTTAGTTAGAGTTAAATGTACCTATAGCCCCTGAATACATGCTCAGGTAGAGAAAGTCTCCATAGTATAAGTAAGTAATATGAATGTG
GAATCTTGGAAAGTGATATATTTTGATTGGAATAATTTTAATTAAATTTAATGATTTTAATTAAGAATTAAAAGCCAGCTAGCCAAATTT
TCTTTAAAAATTGGAAACTCATTATGGTCTTAAATTGTCCTCAGGCAGCCTTTTCCTCATCAACCCATAGAGTGGTCTTTTGAACTGGTA
TCTAAACATACCTGGTTATGAATTCTCAAAAGAGAAAGCAGGTCTGGGGCGGGGTGGTCAGGAGACAGATTCTAGGGAAAGTGCTGAAGA
GATTTTCTTCTGAAGATGATCTAGGAAATGCATCTTTATACATGATTGTTAGCTGCTGTAGCTTTCTGAAGAAGATTGTAGAAAAGAGAC
TAAGATATATGCAAGGGTCACCAGTTTAGAGATCAGTCAAATTGGAAAAAGTGCCAAGACTGGATGTGCAGATTGTTCTATGTATTATCA
GTATTTTTTTCCTCTTAAGAAAAAAATTTACTCTCTCTCCTTTGTGAGTAAATGCCTCCTTAATGCCTTTTAAGTAAGGTGGCAACTTTT
AACTGTCATCTTGTGAGAGGCAACCTCAAACTCTAAGCAGACTCCCTCTCTCCCTTTCTGGTGTCTTAAATCAAGAACTAGTTTGAAGCC
AAGGCAAAGCAAGGTTTGTTCATCTTCCTTTCCTGTCATTTAAGGTAAAACAGGCAATGAACTCGCTCTTCAAATACCATAGTTCAAGAG
TAGCTGTTGGCCCTGGTTCCAGATTAATATAGCAGCAGGCAGATTGCCCCTTCTTGGGGCCACCACCCTCCAAAGCTGTGCCACCAATGA
GAGCATTGGGTTCAAGTTTGCATCAAACATGGTATTACCAACGCTGAGCCTCCAGCAGAGCACTTAAAAGTCCTAGTGAGAGAATAGATA
CTATGCAAGGGAAAAAAATTTAAATGCCAACGAATAGTTTTTTTTTTTTTGAACCTGATACACTGTTTGTTTACTCTCAACTCTTTGTAC
AAATATTATTGTCCTAAGGGCCTTTTCCCCTCCTGCCTAGAAAATAGGTTGTGTATTGGTTTTATTCAACCTGCTGTCTGCTTTAGGATT
GGAGAAGGTACCTGGATCCTTGTGGACTGCCACTGCTGGCTGCCTCCTCTCCAACTCATCAGAAGAGCATTTTGACAAAGACAGAGGACT
TGGACCAGGGCATGCCCTGTTGGGGATGTTTCTGTCAGCAAGGACATGGCATGGAATCAAGTGGGCTGATGTGTTGTTATTTAAACAGTA

>66901_66901_2_POLD3-RNF169_POLD3_chr11_74347320_ENST00000263681_RNF169_chr11_74500671_ENST00000299563_length(amino acids)=940AA_BP=0
MADQLYLENIDEFVTDQNKIVTYKWLSYTLGVHVNQAKQMLYDYVERKRKENSGAQLHVTYLVSGSLIQNGHSCHKVAVVREDKLEAVKS
KLAVTASIHVYSIQKAMLKDSGPLFNTDYDILKSNLQNCSKFSAIQCAAAVPRAPAESSSSSKKFEQSHLHMSSETQANNELTTNGHGPP
ASKQVSQQPKGIMGMFASKAAAKTQETNKETKTEAKEVTNASAAGNKAPGKGNMMSNFFGKAAMNKFKVNLDSEQAVKEEKIVEQPTVSV
TEPKLATPAGLKKSSKKAEPVKVLQKEKKRGKRVALSDDETKETENMRKKRRRIKLPESDSSEDEVFPDSPGAYEAESPSPPPPPSPPLE
PVPKTEPEPPSVKSSSGENKRKRKRVLKSKTYLDGEGCIDFIFRAPIKLSKPGELREEYESLRKLREEKLQEEKPSEDQIHKLLPEDTET
GKRKMDEQKKRDEPLVLKTNLERCPARLSDSENEEPSRGQMTQTHRSAFVSKNNSYSLAFLAGKLNSKVERSQSCSDTAQERAKSRVRAV
PGNKAKVTTMTPASNPIIGVLLSTQNNRCVSAPDLTIEKRLPFSSLSSLASLHKPERSVSPESNDSISEELNHFKPIVCSPCTPPKRLPD
GRVLSPLIIKSTPRNLNRSLQKQTSYEASPRILKKWEQIFQERQIKKTLSKATLTSLAPEMGEELLGSEGIHSSKEKPLVAVNTRLSGGQ
VLSEYTGPTSADLDHFPSVSQTKAEQDSDNKSSTEIPLETCCSSELKGGGSGTSLEREQFEGLGSTPDAKLDKTCISRAMKITTVNSVLP
QNSVLGGVLKTKQQLKTLNHFDLTNGVLVESLSEEPLPSLRRGRKRHCKTKHLEQNGSLKKLRQTSGEVGLAPTDPVLREMEQKLQQEEE

--------------------------------------------------------------
>66901_66901_3_POLD3-RNF169_POLD3_chr11_74347320_ENST00000527458_RNF169_chr11_74500670_ENST00000299563_length(transcript)=8879nt_BP=1571nt
GCTGTGGCTGTGATTGAGAGAGGGGTTAGAGGCGGGTCCCAGCGCTGCCGCACCATGGCGGACCAGCTTTATCTGGAAAATATAGACGAG
TTCGTCACGGACCAAAACAAGATCGTGAGCAGCTACTACTGGGGAACGCGGGCGTGCGACCGGGGTCCTGGGCCCGGCTAGGGCGGCGGG
AGCCTTGACCCTCTGTCTGCTTGTGGCTTCGTGGGGACCAGGGGAGACAGGTCCCCACGAGGGGACCTGGGCGAGCTCTGTGCCCCAGAG
CGAGCGAGGACTCGTCGGGAAGGTCCTCCAGCACACACGGAAGTCCGCGTCCCTTGGGTGGGCGTGCTGGGAACAGAGCCTGGGGCTGGA
GCCGCGGAGACCGGGCGCGGAGGGAGGGCCGTTGGCTGAGAGTTCTAAGGCGTCCCTACACCTTTCTTTTAAGGTGACATACAAATGGCT
GAGCTATACACTAGGGGTTCATGTTAACCAGGCCAAACAGATGCTGTATGATTATGTTGAAAGGAAACGAAAAGAAAATTCAGGAGCCCA
ACTGCATGTTACCTACTTGGTGTCTGGCAGTCTCATTCAGAATGGACATTCCTGCCACAAGGTTGCAGTAGTGAGAGAAGATAAATTGGA
AGCAGTGAAGTCCAAGCTAGCTGTGACTGCCAGCATCCATGTGTACAGCATCCAGAAAGCCATGCTAAAGGACAGTGGGCCTCTGTTCAA
TACTGACTATGACATCCTTAAAAGCAACTTGCAGAACTGCAGCAAATTTAGTGCTATACAATGTGCAGCTGCCGTCCCTAGAGCTCCTGC
TGAATCCTCTTCGTCTTCCAAAAAGTTTGAGCAGTCACATCTTCACATGTCAAGTGAGACACAAGCCAACAATGAGCTGACCACCAATGG
TCATGGCCCACCTGCATCCAAGCAGGTTTCCCAGCAGCCCAAAGGAATTATGGGAATGTTTGCCTCCAAAGCTGCTGCTAAAACCCAAGA
AACCAACAAGGAAACGAAAACAGAGGCTAAAGAAGTAACAAATGCATCTGCAGCAGGCAACAAGGCACCAGGGAAAGGGAATATGATGAG
CAACTTTTTTGGAAAAGCTGCTATGAATAAATTTAAAGTCAATTTGGACTCAGAACAAGCAGTGAAAGAAGAAAAAATAGTGGAGCAGCC
TACAGTGTCTGTCACGGAACCAAAGCTGGCAACTCCTGCAGGCCTGAAAAAATCCAGCAAAAAAGCAGAGCCTGTTAAGGTGCTGCAGAA
GGAAAAAAAAAGGGGGAAGCGAGTAGCATTATCTGATGATGAGACAAAGGAAACTGAAAACATGAGGAAAAAGAGGAGAAGAATCAAACT
TCCTGAATCTGATAGCAGTGAAGATGAAGTCTTTCCAGACTCTCCTGGGGCTTATGAAGCTGAGTCACCATCCCCACCTCCTCCTCCGTC
TCCACCTCTTGAACCAGTGCCAAAGACTGAGCCTGAACCTCCTTCTGTCAAGAGCTCAAGTGGAGAAAACAAAAGAAAACGAAAACGCGT
ACTAAAATCTAAAACTTACCTGGATGGGGAAGGCTGCATAGACTTTATATTCAGAGCACCAATCAAATTAAGCAAGCCTGGGGAACTTCG
TGAGGAATATGAAAGCTTGAGAAAGCTGAGAGAAGAAAAGTTACAAGAGGAAAAACCCTCTGAAGATCAAATCCACAAGCTGTTACCAGA
GGATACAGAAACAGGGAAAAGGAAAATGGATGAACAGAAAAAAAGAGATGAACCATTAGTACTGAAAACAAATCTGGAACGTTGTCCTGC
ACGTCTCTCAGATTCAGAGAATGAAGAACCTTCTCGAGGCCAGATGACACAGACACATCGCTCGGCATTTGTTTCCAAGAACAACTCCTA
CTCCTTAGCTTTCCTGGCAGGGAAGCTAAACTCCAAGGTGGAAAGGAGTCAGAGCTGTAGTGACACAGCCCAGGAAAGAGCGAAGAGCAG
AGTCAGAGCAGTTCCAGGCAACAAAGCCAAGGTCACAACTATGACTCCAGCCTCCAACCCCATCATTGGTGTCCTCTTGTCAACTCAAAA
CAACCGCTGCGTCTCGGCCCCTGACTTAACCATCGAAAAGCGTCTACCCTTCAGCTCCCTTTCATCCTTGGCTTCCCTGCATAAGCCAGA
GCGTTCTGTCAGCCCTGAGAGCAATGACAGCATCTCCGAAGAACTAAACCATTTCAAGCCCATTGTCTGCTCACCATGTACTCCTCCCAA
GAGACTCCCTGATGGCCGTGTGCTAAGTCCTCTCATCATCAAATCAACTCCACGCAACCTAAACAGAAGCCTGCAGAAGCAGACTTCTTA
TGAGGCCAGTCCACGGATCCTCAAAAAGTGGGAACAGATCTTTCAGGAGCGGCAGATCAAAAAGACCCTTTCAAAAGCCACTCTTACCTC
TCTGGCTCCTGAAATGGGGGAAGAGTTACTAGGCTCTGAAGGTATCCATTCTAGCAAGGAGAAGCCACTTGTGGCTGTAAATACAAGATT
ATCTGGTGGGCAGGTCCTCTCTGAGTATACTGGACCCACCTCTGCTGATCTTGATCATTTCCCCTCTGTTAGCCAAACAAAAGCAGAACA
GGACAGTGATAATAAAAGTAGCACTGAGATCCCACTGGAAACCTGCTGTTCCTCAGAACTCAAAGGGGGAGGCAGTGGGACTTCTTTGGA
GAGGGAGCAGTTTGAGGGGTTAGGGTCAACTCCAGATGCCAAGTTAGACAAAACCTGTATAAGCAGAGCCATGAAAATCACCACAGTTAA
TTCAGTGCTACCCCAAAACAGTGTTTTGGGTGGAGTCCTCAAAACAAAGCAACAATTGAAGACATTAAATCATTTTGATCTGACTAATGG
TGTTCTAGTTGAGAGCCTAAGTGAAGAGCCACTTCCTTCTTTGCGTCGAGGCCGGAAAAGACACTGCAAGACCAAGCACTTAGAACAAAA
TGGCTCCCTTAAAAAACTGCGACAAACCAGTGGGGAGGTGGGTCTGGCCCCAACAGACCCAGTCCTGCGAGAGATGGAGCAGAAGCTTCA
GCAAGAGGAAGAAGACCGACAGTTGGCTCTGCAGTTGCAGCGCATGTTCGACAATGAGAGGCGGACTGTGAGCCGGCGAAAAGGAAGTGT
GGATCAGTATCTCCTACGGTCCAGCAACATGGCCGGGGCCAAGTAGCACCTAATGAAGTGTTACCTATTTTTAAAAGGTCTTAGGCCTTG
ATCATTTATCCTGAAGAGCTGAGTGTTCTCACTTTGGTTTTATTTTAATGGCAAAACACTGTCTAATATGGTTCTGAGAGGTTCCAGGGC
CTTTGTAGTCAATATCCAAGGGAAAAGCATCTCCGTTTCTCTGTGACCCAGGCCAGAAGCCTGAGTGACCCATCCCTAAGGGCTTCTGGG
CCAAACCTGGCAGCACCCACTGGGAATGAGATTTGGAACGGCCTCAGGAGCATAATGGCCACAGTTAGTAATGGTAAAGAGGGGATACCT
TCTTAAACTGATAGACTTCCTGACTTCTTTCAGCAGGGTATTGTTTTAAATCAGCCTTGCAGATAAAAATTAATTCCATCTTTTTCAGAC
AAGTGAACAATTTAGTTCCTTGGCAGATCCAAAATGATAGATGGTTATGTTACGCTTTCTGCTGTCCCTTGCCAAAAATAAGTAAATATA
TCAGTTAAGATTATGCCTTTACAAAAGTTAATTTACATTCTCTGTTTAAAAAATAATATTTGGTGAATGCTATATAGTTGACAGAGCACA
TTTACAGACCTTATTAATTTAGTCTTTCCAAGAGACCTCTCATGTAACTGGCATTAGCCCCATTTTTAGATGATGAAACTGCAGTGCAGA
TGTTCTGGTTCTCTCAACTACCAAGTGGCATAACCCATGGATTTTCTAAAGGTTTCCCAAATAGATCACAACCTAAGGGTGTGCCAGGGG
AGCCTAGGGGAAGCTAGGCTGGGCATTGAACACTGATAGTGCAGAATCCACATGCAAACAAGATCGACAGGGTGGATAAACATATATGTG
CATTATCCCCATCCCCCACAGTTTAGAGCCTTCTGCTTTTCTGGGGGTTTCAGCCTATGAGACAAACTATAATCAGGCTTCATTATTACT
TTTCAAATGGCCAAGGGTTATCTGCAATGTTGATCTAAAATCCTAAAAAATCACCCTGAAGTCAGGCAAGGAACAATACTTAAACTCCAT
ACTATGGAAACAAGGTATCTAGCTGGATGCAGCTGGTAAATTCAGTCCCATGGACCTTTGGGGGTTTATTTTCCTTAGCAGCTGACACCA
TGTGTCTTTTGCATCCCTGGTGGTGCTTGGTGCTTCTGCCCATCTGGGCTCATTGAGAATAGGGATGAAGATATGATTTTAGGGAATTTC
TGATGGGCTGGCATGCCCCATGTAGTATGAGTTACTATATAAAGTCATGTGACTGGCATTTTAACAGACCTTCCAGAGCTTATATATCCC
AATATATGTTGTTTCCTTTGAGTAGCCCCAGCAGGATACTGCTTAGTTTTTCCAGTGCCATTGGTGAAAGCATTTCTGGAACTGTCTTCA
AAGACTAGAAACACTGACTCCCAAAATGCTAGAACTGGAAGGGACCTTAATGGTTATCTATTCCAGCCTCCTCCTAAGGTCCTCCTCAGC
TTCTAGACCTAGAAGCCAAAGTCCAGAACAGTGACCCATTGATCAAGGCAGATAGTATAACTCCTTTTAAGTGTTCTCAGATTTGCCTTT
TCTCAGGGCAAATCTTCAGTGTTTTGTGGTTATTTGTGGTTGAGAGAGAGAGAGAATGTAATGTCTGAGACTAGCCAGCAGCTATTTGAA
GCCTCTGGGAAAGAAGGTGGCTTATCAAGTGGGTTTGTAGTAATGAGTGCTGCTGTAAAGCAGAGCCATTTTCTTGTGCAGCTCATAGTT
CCCAAACAGTTCCCAAACAGAAATTCCAGAGATGTCTTAAACATTGTGGTCATCATTGAGATAGGTGGAATCTCTTTGGTGACTACGTTG
GTGGGGAACATCACTCACCTGAATGTATGCATTCTGTGTTCTCTGTGTGTGTGCACATATGCAGATGTATGTTTTAAAAACATTTACCAA
ACTCATGATTTTGTAGTCACACCACTTCAGTTCTGGGCCCTACCAACAATTTATGTCCTCCAAGAGCTGCTGGAGGGCATGTTTGTGCCC
AAAACAGAAGAGCTGGCTCTGGTTTACAGAAGACAGGGAGGGTGACCTTACTATAAATGCCCTTAGAGGAAACTTATCAGTTACTGCCAT
TTCACGCATTTCCTTTTTGATCTTAGTAAATATTATTGGAAGGCTAGTCTTGTTGGTAGGAGCAAAGACACTTATTTTTCCACTTGCCAT
CTTTCTCTATATCTCCAGTAATTTGAAAAACACTTTTCAGTTGGAATTGATTTTTGTCTTTGGTAAAAAGAAATATTTTTAATAGATAAA
AGATATATATTTTAAATATTTCCCCAAATTAATACTTTCATTTTAAGAATTGCATAGCAGTTGTAACAAGTGCAGAATGAAGAACAAATT
CTTGTTAAGCAAATAGTCCAAACTCTAGGTCCAGCTTACTGCCTTCCCCCCTTGTACCTACAGTGATGCCTAGGATGGTATTGACAGTTG
TTTTCTAAACTTCCTGCTGAGCAACAGTCCTTCAAATATAGGTAGAGTGGTCTAGGTTAAGGAGGGAGGAGGGTTGATCTTTAATCAGGT
TGGCTTTGGAGGAAGGAAAAACCACTAAGGTATTATCTGAATTTTAAGATGCTTCCCATCCTTAATAACTAAAACCTGAATGCTTTTCTT
TCTGAAAAATCTCCCTCTCTCCTTCCATGATTCTGAAGTTGGTTAAAAGTCGATATGTTGATGTGTATTATTTGGGGGAACAGAAAAGGA
CAAGGAAGGAAACAGAACGATGGGAAGGGTTTGTGAGCTAGAATAAGAGGTGCAGGATTTCACAAAACAAATTCCTCACAAATCATTGAA
GCCCAGTTCACCATACAAATTACCCATGTCTTACTCTGTTCCTTGTATATATGCATTCTGGGTTTTTTTATTATTAAAGGGGAAGTTAGG
GGGGAGGGTGAAGGTCAGTCTGAGGGGAAATCCAGGAAATGTGGTGCCCTTAGAAGGGGGCTGTCAGCTCTTTTCCATAGAGAGGGAAAG
AAACTTTGAGAAAATGTTCTTGACCCATTGATTGTATCTGCTGGAAGAAGTCATCTGGGCCTGTTGGGTTGGTATCAGATCAGGGGATTA
TGCATCCAGCCCCTGGCCCCTTTAATCTATTTGCCTCTTTTTAAAAAAGGTTAAGTCTTCTTGGGTGAGGCTTGCCAGGGAAACTCCTAA
GTGGCTTCACTTATTTTTTAAATTTTAATTTAATTTTTAAATTTTTGCTTGGAAGCAGCACTGGTAATAAATGTTTTATTTTTTGTTCAT
TTTCCCTAAAGGAAAAATGTCCTTAAGAGATTAAAGCTCTTAATTGATTACTGTCTGGTTACAAACTGGCAAACTGACTAAAATGGGAAG
CTGCCACCGTGCCTGACTCATGTAGCTGATGACCGAAGGCTCATCCTTTCTTTTCTATTTGACAGACATTTACTGAGCTTCAGACTTGAG
CCAACCCTGAGCTGGACTGTGGAGATAAAGCAGTTCCTGCTCTTGAGGAGCTCAATGTCTAATGGAATGCATTTGAATGTATGTGTGGCT
GGAGAGTTCATTTATGGTCTTAGGAAAGCCATTTCTGGTCCCATTTAGAAAACTGACCAGCACCCAGCAAGCTGCATTCTACATTTTAGA
GACCCCATTGGTATTTGTGAATTTGATTGCACCACCGCTTTTCCTTTACTAAGTAATGTTATGGAAGGAGAATGAATTTTCTCCTCTAGT
GATTACAGGACATTAACATCTCTTCAGAAGCTGCTTTTAGCTTAAGCCCCAAGAAGTGAGGTGGGTTGTGGATCACTGACATGGTCAGGG
GAGGCCCACACCTCAATTCAGTAACCACCTAATCTCTCCCCCAACCTGATCTCTCATCAGAGCTGGCAGCAACTTGGGATTCCTTTCCTT
TTTCCTGCCTAACTTTTCATTGAAATGTCTAGTAGGAGAGTGAGAAAAGAGAACAAAGGCTGGGTCACAGTCATAGAATGTTACAGCTGG
AATGGGCATGGAAATCATCCAAGTTAAACTTCTTCTCTGCCCCCCGCCCCCACTTTTTTTTTTTTTTTTTTTTAACCAAACGAACTTGTG
ATCCAGTGCCCTATTTTATAGTGTGGTTTTCCAGGGTCTGAATAAATAATCATTAAAGTTTGACACACGCAGACACACGCACCAATGATG
GGGATACCCCCAAATGATTTAGGAGGTTATTTTATTTTAATAGTTTTTTCTTCCTGATTTTTTTCAGTTAGTTAGAGTTAAATGTACCTA
TAGCCCCTGAATACATGCTCAGGTAGAGAAAGTCTCCATAGTATAAGTAAGTAATATGAATGTGGAATCTTGGAAAGTGATATATTTTGA
TTGGAATAATTTTAATTAAATTTAATGATTTTAATTAAGAATTAAAAGCCAGCTAGCCAAATTTTCTTTAAAAATTGGAAACTCATTATG
GTCTTAAATTGTCCTCAGGCAGCCTTTTCCTCATCAACCCATAGAGTGGTCTTTTGAACTGGTATCTAAACATACCTGGTTATGAATTCT
CAAAAGAGAAAGCAGGTCTGGGGCGGGGTGGTCAGGAGACAGATTCTAGGGAAAGTGCTGAAGAGATTTTCTTCTGAAGATGATCTAGGA
AATGCATCTTTATACATGATTGTTAGCTGCTGTAGCTTTCTGAAGAAGATTGTAGAAAAGAGACTAAGATATATGCAAGGGTCACCAGTT
TAGAGATCAGTCAAATTGGAAAAAGTGCCAAGACTGGATGTGCAGATTGTTCTATGTATTATCAGTATTTTTTTCCTCTTAAGAAAAAAA
TTTACTCTCTCTCCTTTGTGAGTAAATGCCTCCTTAATGCCTTTTAAGTAAGGTGGCAACTTTTAACTGTCATCTTGTGAGAGGCAACCT
CAAACTCTAAGCAGACTCCCTCTCTCCCTTTCTGGTGTCTTAAATCAAGAACTAGTTTGAAGCCAAGGCAAAGCAAGGTTTGTTCATCTT
CCTTTCCTGTCATTTAAGGTAAAACAGGCAATGAACTCGCTCTTCAAATACCATAGTTCAAGAGTAGCTGTTGGCCCTGGTTCCAGATTA
ATATAGCAGCAGGCAGATTGCCCCTTCTTGGGGCCACCACCCTCCAAAGCTGTGCCACCAATGAGAGCATTGGGTTCAAGTTTGCATCAA
ACATGGTATTACCAACGCTGAGCCTCCAGCAGAGCACTTAAAAGTCCTAGTGAGAGAATAGATACTATGCAAGGGAAAAAAATTTAAATG
CCAACGAATAGTTTTTTTTTTTTTGAACCTGATACACTGTTTGTTTACTCTCAACTCTTTGTACAAATATTATTGTCCTAAGGGCCTTTT
CCCCTCCTGCCTAGAAAATAGGTTGTGTATTGGTTTTATTCAACCTGCTGTCTGCTTTAGGATTGGAGAAGGTACCTGGATCCTTGTGGA
CTGCCACTGCTGGCTGCCTCCTCTCCAACTCATCAGAAGAGCATTTTGACAAAGACAGAGGACTTGGACCAGGGCATGCCCTGTTGGGGA
TGTTTCTGTCAGCAAGGACATGGCATGGAATCAAGTGGGCTGATGTGTTGTTATTTAAACAGTACCAAAGTGCATTCTTCAATGTATGTT

>66901_66901_3_POLD3-RNF169_POLD3_chr11_74347320_ENST00000527458_RNF169_chr11_74500670_ENST00000299563_length(amino acids)=1012AA_BP=1
MGPARAAGALTLCLLVASWGPGETGPHEGTWASSVPQSERGLVGKVLQHTRKSASLGWACWEQSLGLEPRRPGAEGGPLAESSKASLHLS
FKVTYKWLSYTLGVHVNQAKQMLYDYVERKRKENSGAQLHVTYLVSGSLIQNGHSCHKVAVVREDKLEAVKSKLAVTASIHVYSIQKAML
KDSGPLFNTDYDILKSNLQNCSKFSAIQCAAAVPRAPAESSSSSKKFEQSHLHMSSETQANNELTTNGHGPPASKQVSQQPKGIMGMFAS
KAAAKTQETNKETKTEAKEVTNASAAGNKAPGKGNMMSNFFGKAAMNKFKVNLDSEQAVKEEKIVEQPTVSVTEPKLATPAGLKKSSKKA
EPVKVLQKEKKRGKRVALSDDETKETENMRKKRRRIKLPESDSSEDEVFPDSPGAYEAESPSPPPPPSPPLEPVPKTEPEPPSVKSSSGE
NKRKRKRVLKSKTYLDGEGCIDFIFRAPIKLSKPGELREEYESLRKLREEKLQEEKPSEDQIHKLLPEDTETGKRKMDEQKKRDEPLVLK
TNLERCPARLSDSENEEPSRGQMTQTHRSAFVSKNNSYSLAFLAGKLNSKVERSQSCSDTAQERAKSRVRAVPGNKAKVTTMTPASNPII
GVLLSTQNNRCVSAPDLTIEKRLPFSSLSSLASLHKPERSVSPESNDSISEELNHFKPIVCSPCTPPKRLPDGRVLSPLIIKSTPRNLNR
SLQKQTSYEASPRILKKWEQIFQERQIKKTLSKATLTSLAPEMGEELLGSEGIHSSKEKPLVAVNTRLSGGQVLSEYTGPTSADLDHFPS
VSQTKAEQDSDNKSSTEIPLETCCSSELKGGGSGTSLEREQFEGLGSTPDAKLDKTCISRAMKITTVNSVLPQNSVLGGVLKTKQQLKTL
NHFDLTNGVLVESLSEEPLPSLRRGRKRHCKTKHLEQNGSLKKLRQTSGEVGLAPTDPVLREMEQKLQQEEEDRQLALQLQRMFDNERRT

--------------------------------------------------------------
>66901_66901_4_POLD3-RNF169_POLD3_chr11_74347320_ENST00000527458_RNF169_chr11_74500671_ENST00000299563_length(transcript)=8879nt_BP=1571nt
GCTGTGGCTGTGATTGAGAGAGGGGTTAGAGGCGGGTCCCAGCGCTGCCGCACCATGGCGGACCAGCTTTATCTGGAAAATATAGACGAG
TTCGTCACGGACCAAAACAAGATCGTGAGCAGCTACTACTGGGGAACGCGGGCGTGCGACCGGGGTCCTGGGCCCGGCTAGGGCGGCGGG
AGCCTTGACCCTCTGTCTGCTTGTGGCTTCGTGGGGACCAGGGGAGACAGGTCCCCACGAGGGGACCTGGGCGAGCTCTGTGCCCCAGAG
CGAGCGAGGACTCGTCGGGAAGGTCCTCCAGCACACACGGAAGTCCGCGTCCCTTGGGTGGGCGTGCTGGGAACAGAGCCTGGGGCTGGA
GCCGCGGAGACCGGGCGCGGAGGGAGGGCCGTTGGCTGAGAGTTCTAAGGCGTCCCTACACCTTTCTTTTAAGGTGACATACAAATGGCT
GAGCTATACACTAGGGGTTCATGTTAACCAGGCCAAACAGATGCTGTATGATTATGTTGAAAGGAAACGAAAAGAAAATTCAGGAGCCCA
ACTGCATGTTACCTACTTGGTGTCTGGCAGTCTCATTCAGAATGGACATTCCTGCCACAAGGTTGCAGTAGTGAGAGAAGATAAATTGGA
AGCAGTGAAGTCCAAGCTAGCTGTGACTGCCAGCATCCATGTGTACAGCATCCAGAAAGCCATGCTAAAGGACAGTGGGCCTCTGTTCAA
TACTGACTATGACATCCTTAAAAGCAACTTGCAGAACTGCAGCAAATTTAGTGCTATACAATGTGCAGCTGCCGTCCCTAGAGCTCCTGC
TGAATCCTCTTCGTCTTCCAAAAAGTTTGAGCAGTCACATCTTCACATGTCAAGTGAGACACAAGCCAACAATGAGCTGACCACCAATGG
TCATGGCCCACCTGCATCCAAGCAGGTTTCCCAGCAGCCCAAAGGAATTATGGGAATGTTTGCCTCCAAAGCTGCTGCTAAAACCCAAGA
AACCAACAAGGAAACGAAAACAGAGGCTAAAGAAGTAACAAATGCATCTGCAGCAGGCAACAAGGCACCAGGGAAAGGGAATATGATGAG
CAACTTTTTTGGAAAAGCTGCTATGAATAAATTTAAAGTCAATTTGGACTCAGAACAAGCAGTGAAAGAAGAAAAAATAGTGGAGCAGCC
TACAGTGTCTGTCACGGAACCAAAGCTGGCAACTCCTGCAGGCCTGAAAAAATCCAGCAAAAAAGCAGAGCCTGTTAAGGTGCTGCAGAA
GGAAAAAAAAAGGGGGAAGCGAGTAGCATTATCTGATGATGAGACAAAGGAAACTGAAAACATGAGGAAAAAGAGGAGAAGAATCAAACT
TCCTGAATCTGATAGCAGTGAAGATGAAGTCTTTCCAGACTCTCCTGGGGCTTATGAAGCTGAGTCACCATCCCCACCTCCTCCTCCGTC
TCCACCTCTTGAACCAGTGCCAAAGACTGAGCCTGAACCTCCTTCTGTCAAGAGCTCAAGTGGAGAAAACAAAAGAAAACGAAAACGCGT
ACTAAAATCTAAAACTTACCTGGATGGGGAAGGCTGCATAGACTTTATATTCAGAGCACCAATCAAATTAAGCAAGCCTGGGGAACTTCG
TGAGGAATATGAAAGCTTGAGAAAGCTGAGAGAAGAAAAGTTACAAGAGGAAAAACCCTCTGAAGATCAAATCCACAAGCTGTTACCAGA
GGATACAGAAACAGGGAAAAGGAAAATGGATGAACAGAAAAAAAGAGATGAACCATTAGTACTGAAAACAAATCTGGAACGTTGTCCTGC
ACGTCTCTCAGATTCAGAGAATGAAGAACCTTCTCGAGGCCAGATGACACAGACACATCGCTCGGCATTTGTTTCCAAGAACAACTCCTA
CTCCTTAGCTTTCCTGGCAGGGAAGCTAAACTCCAAGGTGGAAAGGAGTCAGAGCTGTAGTGACACAGCCCAGGAAAGAGCGAAGAGCAG
AGTCAGAGCAGTTCCAGGCAACAAAGCCAAGGTCACAACTATGACTCCAGCCTCCAACCCCATCATTGGTGTCCTCTTGTCAACTCAAAA
CAACCGCTGCGTCTCGGCCCCTGACTTAACCATCGAAAAGCGTCTACCCTTCAGCTCCCTTTCATCCTTGGCTTCCCTGCATAAGCCAGA
GCGTTCTGTCAGCCCTGAGAGCAATGACAGCATCTCCGAAGAACTAAACCATTTCAAGCCCATTGTCTGCTCACCATGTACTCCTCCCAA
GAGACTCCCTGATGGCCGTGTGCTAAGTCCTCTCATCATCAAATCAACTCCACGCAACCTAAACAGAAGCCTGCAGAAGCAGACTTCTTA
TGAGGCCAGTCCACGGATCCTCAAAAAGTGGGAACAGATCTTTCAGGAGCGGCAGATCAAAAAGACCCTTTCAAAAGCCACTCTTACCTC
TCTGGCTCCTGAAATGGGGGAAGAGTTACTAGGCTCTGAAGGTATCCATTCTAGCAAGGAGAAGCCACTTGTGGCTGTAAATACAAGATT
ATCTGGTGGGCAGGTCCTCTCTGAGTATACTGGACCCACCTCTGCTGATCTTGATCATTTCCCCTCTGTTAGCCAAACAAAAGCAGAACA
GGACAGTGATAATAAAAGTAGCACTGAGATCCCACTGGAAACCTGCTGTTCCTCAGAACTCAAAGGGGGAGGCAGTGGGACTTCTTTGGA
GAGGGAGCAGTTTGAGGGGTTAGGGTCAACTCCAGATGCCAAGTTAGACAAAACCTGTATAAGCAGAGCCATGAAAATCACCACAGTTAA
TTCAGTGCTACCCCAAAACAGTGTTTTGGGTGGAGTCCTCAAAACAAAGCAACAATTGAAGACATTAAATCATTTTGATCTGACTAATGG
TGTTCTAGTTGAGAGCCTAAGTGAAGAGCCACTTCCTTCTTTGCGTCGAGGCCGGAAAAGACACTGCAAGACCAAGCACTTAGAACAAAA
TGGCTCCCTTAAAAAACTGCGACAAACCAGTGGGGAGGTGGGTCTGGCCCCAACAGACCCAGTCCTGCGAGAGATGGAGCAGAAGCTTCA
GCAAGAGGAAGAAGACCGACAGTTGGCTCTGCAGTTGCAGCGCATGTTCGACAATGAGAGGCGGACTGTGAGCCGGCGAAAAGGAAGTGT
GGATCAGTATCTCCTACGGTCCAGCAACATGGCCGGGGCCAAGTAGCACCTAATGAAGTGTTACCTATTTTTAAAAGGTCTTAGGCCTTG
ATCATTTATCCTGAAGAGCTGAGTGTTCTCACTTTGGTTTTATTTTAATGGCAAAACACTGTCTAATATGGTTCTGAGAGGTTCCAGGGC
CTTTGTAGTCAATATCCAAGGGAAAAGCATCTCCGTTTCTCTGTGACCCAGGCCAGAAGCCTGAGTGACCCATCCCTAAGGGCTTCTGGG
CCAAACCTGGCAGCACCCACTGGGAATGAGATTTGGAACGGCCTCAGGAGCATAATGGCCACAGTTAGTAATGGTAAAGAGGGGATACCT
TCTTAAACTGATAGACTTCCTGACTTCTTTCAGCAGGGTATTGTTTTAAATCAGCCTTGCAGATAAAAATTAATTCCATCTTTTTCAGAC
AAGTGAACAATTTAGTTCCTTGGCAGATCCAAAATGATAGATGGTTATGTTACGCTTTCTGCTGTCCCTTGCCAAAAATAAGTAAATATA
TCAGTTAAGATTATGCCTTTACAAAAGTTAATTTACATTCTCTGTTTAAAAAATAATATTTGGTGAATGCTATATAGTTGACAGAGCACA
TTTACAGACCTTATTAATTTAGTCTTTCCAAGAGACCTCTCATGTAACTGGCATTAGCCCCATTTTTAGATGATGAAACTGCAGTGCAGA
TGTTCTGGTTCTCTCAACTACCAAGTGGCATAACCCATGGATTTTCTAAAGGTTTCCCAAATAGATCACAACCTAAGGGTGTGCCAGGGG
AGCCTAGGGGAAGCTAGGCTGGGCATTGAACACTGATAGTGCAGAATCCACATGCAAACAAGATCGACAGGGTGGATAAACATATATGTG
CATTATCCCCATCCCCCACAGTTTAGAGCCTTCTGCTTTTCTGGGGGTTTCAGCCTATGAGACAAACTATAATCAGGCTTCATTATTACT
TTTCAAATGGCCAAGGGTTATCTGCAATGTTGATCTAAAATCCTAAAAAATCACCCTGAAGTCAGGCAAGGAACAATACTTAAACTCCAT
ACTATGGAAACAAGGTATCTAGCTGGATGCAGCTGGTAAATTCAGTCCCATGGACCTTTGGGGGTTTATTTTCCTTAGCAGCTGACACCA
TGTGTCTTTTGCATCCCTGGTGGTGCTTGGTGCTTCTGCCCATCTGGGCTCATTGAGAATAGGGATGAAGATATGATTTTAGGGAATTTC
TGATGGGCTGGCATGCCCCATGTAGTATGAGTTACTATATAAAGTCATGTGACTGGCATTTTAACAGACCTTCCAGAGCTTATATATCCC
AATATATGTTGTTTCCTTTGAGTAGCCCCAGCAGGATACTGCTTAGTTTTTCCAGTGCCATTGGTGAAAGCATTTCTGGAACTGTCTTCA
AAGACTAGAAACACTGACTCCCAAAATGCTAGAACTGGAAGGGACCTTAATGGTTATCTATTCCAGCCTCCTCCTAAGGTCCTCCTCAGC
TTCTAGACCTAGAAGCCAAAGTCCAGAACAGTGACCCATTGATCAAGGCAGATAGTATAACTCCTTTTAAGTGTTCTCAGATTTGCCTTT
TCTCAGGGCAAATCTTCAGTGTTTTGTGGTTATTTGTGGTTGAGAGAGAGAGAGAATGTAATGTCTGAGACTAGCCAGCAGCTATTTGAA
GCCTCTGGGAAAGAAGGTGGCTTATCAAGTGGGTTTGTAGTAATGAGTGCTGCTGTAAAGCAGAGCCATTTTCTTGTGCAGCTCATAGTT
CCCAAACAGTTCCCAAACAGAAATTCCAGAGATGTCTTAAACATTGTGGTCATCATTGAGATAGGTGGAATCTCTTTGGTGACTACGTTG
GTGGGGAACATCACTCACCTGAATGTATGCATTCTGTGTTCTCTGTGTGTGTGCACATATGCAGATGTATGTTTTAAAAACATTTACCAA
ACTCATGATTTTGTAGTCACACCACTTCAGTTCTGGGCCCTACCAACAATTTATGTCCTCCAAGAGCTGCTGGAGGGCATGTTTGTGCCC
AAAACAGAAGAGCTGGCTCTGGTTTACAGAAGACAGGGAGGGTGACCTTACTATAAATGCCCTTAGAGGAAACTTATCAGTTACTGCCAT
TTCACGCATTTCCTTTTTGATCTTAGTAAATATTATTGGAAGGCTAGTCTTGTTGGTAGGAGCAAAGACACTTATTTTTCCACTTGCCAT
CTTTCTCTATATCTCCAGTAATTTGAAAAACACTTTTCAGTTGGAATTGATTTTTGTCTTTGGTAAAAAGAAATATTTTTAATAGATAAA
AGATATATATTTTAAATATTTCCCCAAATTAATACTTTCATTTTAAGAATTGCATAGCAGTTGTAACAAGTGCAGAATGAAGAACAAATT
CTTGTTAAGCAAATAGTCCAAACTCTAGGTCCAGCTTACTGCCTTCCCCCCTTGTACCTACAGTGATGCCTAGGATGGTATTGACAGTTG
TTTTCTAAACTTCCTGCTGAGCAACAGTCCTTCAAATATAGGTAGAGTGGTCTAGGTTAAGGAGGGAGGAGGGTTGATCTTTAATCAGGT
TGGCTTTGGAGGAAGGAAAAACCACTAAGGTATTATCTGAATTTTAAGATGCTTCCCATCCTTAATAACTAAAACCTGAATGCTTTTCTT
TCTGAAAAATCTCCCTCTCTCCTTCCATGATTCTGAAGTTGGTTAAAAGTCGATATGTTGATGTGTATTATTTGGGGGAACAGAAAAGGA
CAAGGAAGGAAACAGAACGATGGGAAGGGTTTGTGAGCTAGAATAAGAGGTGCAGGATTTCACAAAACAAATTCCTCACAAATCATTGAA
GCCCAGTTCACCATACAAATTACCCATGTCTTACTCTGTTCCTTGTATATATGCATTCTGGGTTTTTTTATTATTAAAGGGGAAGTTAGG
GGGGAGGGTGAAGGTCAGTCTGAGGGGAAATCCAGGAAATGTGGTGCCCTTAGAAGGGGGCTGTCAGCTCTTTTCCATAGAGAGGGAAAG
AAACTTTGAGAAAATGTTCTTGACCCATTGATTGTATCTGCTGGAAGAAGTCATCTGGGCCTGTTGGGTTGGTATCAGATCAGGGGATTA
TGCATCCAGCCCCTGGCCCCTTTAATCTATTTGCCTCTTTTTAAAAAAGGTTAAGTCTTCTTGGGTGAGGCTTGCCAGGGAAACTCCTAA
GTGGCTTCACTTATTTTTTAAATTTTAATTTAATTTTTAAATTTTTGCTTGGAAGCAGCACTGGTAATAAATGTTTTATTTTTTGTTCAT
TTTCCCTAAAGGAAAAATGTCCTTAAGAGATTAAAGCTCTTAATTGATTACTGTCTGGTTACAAACTGGCAAACTGACTAAAATGGGAAG
CTGCCACCGTGCCTGACTCATGTAGCTGATGACCGAAGGCTCATCCTTTCTTTTCTATTTGACAGACATTTACTGAGCTTCAGACTTGAG
CCAACCCTGAGCTGGACTGTGGAGATAAAGCAGTTCCTGCTCTTGAGGAGCTCAATGTCTAATGGAATGCATTTGAATGTATGTGTGGCT
GGAGAGTTCATTTATGGTCTTAGGAAAGCCATTTCTGGTCCCATTTAGAAAACTGACCAGCACCCAGCAAGCTGCATTCTACATTTTAGA
GACCCCATTGGTATTTGTGAATTTGATTGCACCACCGCTTTTCCTTTACTAAGTAATGTTATGGAAGGAGAATGAATTTTCTCCTCTAGT
GATTACAGGACATTAACATCTCTTCAGAAGCTGCTTTTAGCTTAAGCCCCAAGAAGTGAGGTGGGTTGTGGATCACTGACATGGTCAGGG
GAGGCCCACACCTCAATTCAGTAACCACCTAATCTCTCCCCCAACCTGATCTCTCATCAGAGCTGGCAGCAACTTGGGATTCCTTTCCTT
TTTCCTGCCTAACTTTTCATTGAAATGTCTAGTAGGAGAGTGAGAAAAGAGAACAAAGGCTGGGTCACAGTCATAGAATGTTACAGCTGG
AATGGGCATGGAAATCATCCAAGTTAAACTTCTTCTCTGCCCCCCGCCCCCACTTTTTTTTTTTTTTTTTTTTAACCAAACGAACTTGTG
ATCCAGTGCCCTATTTTATAGTGTGGTTTTCCAGGGTCTGAATAAATAATCATTAAAGTTTGACACACGCAGACACACGCACCAATGATG
GGGATACCCCCAAATGATTTAGGAGGTTATTTTATTTTAATAGTTTTTTCTTCCTGATTTTTTTCAGTTAGTTAGAGTTAAATGTACCTA
TAGCCCCTGAATACATGCTCAGGTAGAGAAAGTCTCCATAGTATAAGTAAGTAATATGAATGTGGAATCTTGGAAAGTGATATATTTTGA
TTGGAATAATTTTAATTAAATTTAATGATTTTAATTAAGAATTAAAAGCCAGCTAGCCAAATTTTCTTTAAAAATTGGAAACTCATTATG
GTCTTAAATTGTCCTCAGGCAGCCTTTTCCTCATCAACCCATAGAGTGGTCTTTTGAACTGGTATCTAAACATACCTGGTTATGAATTCT
CAAAAGAGAAAGCAGGTCTGGGGCGGGGTGGTCAGGAGACAGATTCTAGGGAAAGTGCTGAAGAGATTTTCTTCTGAAGATGATCTAGGA
AATGCATCTTTATACATGATTGTTAGCTGCTGTAGCTTTCTGAAGAAGATTGTAGAAAAGAGACTAAGATATATGCAAGGGTCACCAGTT
TAGAGATCAGTCAAATTGGAAAAAGTGCCAAGACTGGATGTGCAGATTGTTCTATGTATTATCAGTATTTTTTTCCTCTTAAGAAAAAAA
TTTACTCTCTCTCCTTTGTGAGTAAATGCCTCCTTAATGCCTTTTAAGTAAGGTGGCAACTTTTAACTGTCATCTTGTGAGAGGCAACCT
CAAACTCTAAGCAGACTCCCTCTCTCCCTTTCTGGTGTCTTAAATCAAGAACTAGTTTGAAGCCAAGGCAAAGCAAGGTTTGTTCATCTT
CCTTTCCTGTCATTTAAGGTAAAACAGGCAATGAACTCGCTCTTCAAATACCATAGTTCAAGAGTAGCTGTTGGCCCTGGTTCCAGATTA
ATATAGCAGCAGGCAGATTGCCCCTTCTTGGGGCCACCACCCTCCAAAGCTGTGCCACCAATGAGAGCATTGGGTTCAAGTTTGCATCAA
ACATGGTATTACCAACGCTGAGCCTCCAGCAGAGCACTTAAAAGTCCTAGTGAGAGAATAGATACTATGCAAGGGAAAAAAATTTAAATG
CCAACGAATAGTTTTTTTTTTTTTGAACCTGATACACTGTTTGTTTACTCTCAACTCTTTGTACAAATATTATTGTCCTAAGGGCCTTTT
CCCCTCCTGCCTAGAAAATAGGTTGTGTATTGGTTTTATTCAACCTGCTGTCTGCTTTAGGATTGGAGAAGGTACCTGGATCCTTGTGGA
CTGCCACTGCTGGCTGCCTCCTCTCCAACTCATCAGAAGAGCATTTTGACAAAGACAGAGGACTTGGACCAGGGCATGCCCTGTTGGGGA
TGTTTCTGTCAGCAAGGACATGGCATGGAATCAAGTGGGCTGATGTGTTGTTATTTAAACAGTACCAAAGTGCATTCTTCAATGTATGTT

>66901_66901_4_POLD3-RNF169_POLD3_chr11_74347320_ENST00000527458_RNF169_chr11_74500671_ENST00000299563_length(amino acids)=1012AA_BP=1
MGPARAAGALTLCLLVASWGPGETGPHEGTWASSVPQSERGLVGKVLQHTRKSASLGWACWEQSLGLEPRRPGAEGGPLAESSKASLHLS
FKVTYKWLSYTLGVHVNQAKQMLYDYVERKRKENSGAQLHVTYLVSGSLIQNGHSCHKVAVVREDKLEAVKSKLAVTASIHVYSIQKAML
KDSGPLFNTDYDILKSNLQNCSKFSAIQCAAAVPRAPAESSSSSKKFEQSHLHMSSETQANNELTTNGHGPPASKQVSQQPKGIMGMFAS
KAAAKTQETNKETKTEAKEVTNASAAGNKAPGKGNMMSNFFGKAAMNKFKVNLDSEQAVKEEKIVEQPTVSVTEPKLATPAGLKKSSKKA
EPVKVLQKEKKRGKRVALSDDETKETENMRKKRRRIKLPESDSSEDEVFPDSPGAYEAESPSPPPPPSPPLEPVPKTEPEPPSVKSSSGE
NKRKRKRVLKSKTYLDGEGCIDFIFRAPIKLSKPGELREEYESLRKLREEKLQEEKPSEDQIHKLLPEDTETGKRKMDEQKKRDEPLVLK
TNLERCPARLSDSENEEPSRGQMTQTHRSAFVSKNNSYSLAFLAGKLNSKVERSQSCSDTAQERAKSRVRAVPGNKAKVTTMTPASNPII
GVLLSTQNNRCVSAPDLTIEKRLPFSSLSSLASLHKPERSVSPESNDSISEELNHFKPIVCSPCTPPKRLPDGRVLSPLIIKSTPRNLNR
SLQKQTSYEASPRILKKWEQIFQERQIKKTLSKATLTSLAPEMGEELLGSEGIHSSKEKPLVAVNTRLSGGQVLSEYTGPTSADLDHFPS
VSQTKAEQDSDNKSSTEIPLETCCSSELKGGGSGTSLEREQFEGLGSTPDAKLDKTCISRAMKITTVNSVLPQNSVLGGVLKTKQQLKTL
NHFDLTNGVLVESLSEEPLPSLRRGRKRHCKTKHLEQNGSLKKLRQTSGEVGLAPTDPVLREMEQKLQQEEEDRQLALQLQRMFDNERRT

--------------------------------------------------------------
>66901_66901_5_POLD3-RNF169_POLD3_chr11_74347320_ENST00000532497_RNF169_chr11_74500670_ENST00000299563_length(transcript)=8457nt_BP=1149nt
GCTGTGGCTGTGATTGAGAGAGGGGTTAGAGGCGGGTCCCAGCGCTGCCGCACCATGGCGGACCAGCTTTATCTGGAAAATATAGACGAG
TTCGTCACGGACCAAAACAAGATCGTGACATACAAATGGCTGAGCTATACACTAGGGGTTCATGTTAACCAGGCCAAACATGCCACAAGG
TTGCAGTAGTGAGAGAAGATAAATTGGAAGCAGTGAAGTCCAAGCTAGCTGTGACTGCCAGCATCCATGTGTACAGCATCCAGAAAGCCA
TGCTAAAGGACAGTGGGCCTCTGTTCAATACTGACTATGACATCCTTAAAAGCAACTTGCAGAACTGCAGCAAATTTAGTGCTATACAAT
GTGCAGCTGCCGTCCCTAGAGCTCCTGCTGAATCCTCTTCGTCTTCCAAAAAGTTTGAGCAGTCACATCTTCACATGTCAAGTGAGACAC
AAGCCAACAATGAGCTGACCACCAATGGTCATGGCCCACCTGCATCCAAGCAGGTTTCCCAGCAGCCCAAAGGAATTATGGGAATGTTTG
CCTCCAAAGCTGCTGCTAAAACCCAAGAAACCAACAAGGAAACGAAAACAGAGGCTAAAGAAGTAACAAATGCATCTGCAGCAGGCAACA
AGGCACCAGGGAAAGGGAATATGATGAGCAACTTTTTTGGAAAAGCTGCTATGAATAAATTTAAAGTCAATTTGGACTCAGAACAAGCAG
TGAAAGAAGAAAAAATAGTGGAGCAGCCTACAGTGTCTGTCACGGAACCAAAGCTGGCAACTCCTGCAGGCCTGAAAAAATCCAGCAAAA
AAGCAGAGCCTGTTAAGGTGCTGCAGAAGGAAAAAAAAAGGGGGAAGCGAGTAGCATTATCTGATGATGAGACAAAGGAAACTGAAAACA
TGAGGAAAAAGAGGAGAAGAATCAAACTTCCTGAATCTGATAGCAGTGAAGATGAAGTCTTTCCAGACTCTCCTGGGGCTTATGAAGCTG
AGTCACCATCCCCACCTCCTCCTCCGTCTCCACCTCTTGAACCAGTGCCAAAGACTGAGCCTGAACCTCCTTCTGTCAAGAGCTCAAGTG
GAGAAAACAAAAGAAAACGAAAACGCGTACTAAAATCTAAAACTTACCTGGATGGGGAAGGCTGCATAGACTTTATATTCAGAGCACCAA
TCAAATTAAGCAAGCCTGGGGAACTTCGTGAGGAATATGAAAGCTTGAGAAAGCTGAGAGAAGAAAAGTTACAAGAGGAAAAACCCTCTG
AAGATCAAATCCACAAGCTGTTACCAGAGGATACAGAAACAGGGAAAAGGAAAATGGATGAACAGAAAAAAAGAGATGAACCATTAGTAC
TGAAAACAAATCTGGAACGTTGTCCTGCACGTCTCTCAGATTCAGAGAATGAAGAACCTTCTCGAGGCCAGATGACACAGACACATCGCT
CGGCATTTGTTTCCAAGAACAACTCCTACTCCTTAGCTTTCCTGGCAGGGAAGCTAAACTCCAAGGTGGAAAGGAGTCAGAGCTGTAGTG
ACACAGCCCAGGAAAGAGCGAAGAGCAGAGTCAGAGCAGTTCCAGGCAACAAAGCCAAGGTCACAACTATGACTCCAGCCTCCAACCCCA
TCATTGGTGTCCTCTTGTCAACTCAAAACAACCGCTGCGTCTCGGCCCCTGACTTAACCATCGAAAAGCGTCTACCCTTCAGCTCCCTTT
CATCCTTGGCTTCCCTGCATAAGCCAGAGCGTTCTGTCAGCCCTGAGAGCAATGACAGCATCTCCGAAGAACTAAACCATTTCAAGCCCA
TTGTCTGCTCACCATGTACTCCTCCCAAGAGACTCCCTGATGGCCGTGTGCTAAGTCCTCTCATCATCAAATCAACTCCACGCAACCTAA
ACAGAAGCCTGCAGAAGCAGACTTCTTATGAGGCCAGTCCACGGATCCTCAAAAAGTGGGAACAGATCTTTCAGGAGCGGCAGATCAAAA
AGACCCTTTCAAAAGCCACTCTTACCTCTCTGGCTCCTGAAATGGGGGAAGAGTTACTAGGCTCTGAAGGTATCCATTCTAGCAAGGAGA
AGCCACTTGTGGCTGTAAATACAAGATTATCTGGTGGGCAGGTCCTCTCTGAGTATACTGGACCCACCTCTGCTGATCTTGATCATTTCC
CCTCTGTTAGCCAAACAAAAGCAGAACAGGACAGTGATAATAAAAGTAGCACTGAGATCCCACTGGAAACCTGCTGTTCCTCAGAACTCA
AAGGGGGAGGCAGTGGGACTTCTTTGGAGAGGGAGCAGTTTGAGGGGTTAGGGTCAACTCCAGATGCCAAGTTAGACAAAACCTGTATAA
GCAGAGCCATGAAAATCACCACAGTTAATTCAGTGCTACCCCAAAACAGTGTTTTGGGTGGAGTCCTCAAAACAAAGCAACAATTGAAGA
CATTAAATCATTTTGATCTGACTAATGGTGTTCTAGTTGAGAGCCTAAGTGAAGAGCCACTTCCTTCTTTGCGTCGAGGCCGGAAAAGAC
ACTGCAAGACCAAGCACTTAGAACAAAATGGCTCCCTTAAAAAACTGCGACAAACCAGTGGGGAGGTGGGTCTGGCCCCAACAGACCCAG
TCCTGCGAGAGATGGAGCAGAAGCTTCAGCAAGAGGAAGAAGACCGACAGTTGGCTCTGCAGTTGCAGCGCATGTTCGACAATGAGAGGC
GGACTGTGAGCCGGCGAAAAGGAAGTGTGGATCAGTATCTCCTACGGTCCAGCAACATGGCCGGGGCCAAGTAGCACCTAATGAAGTGTT
ACCTATTTTTAAAAGGTCTTAGGCCTTGATCATTTATCCTGAAGAGCTGAGTGTTCTCACTTTGGTTTTATTTTAATGGCAAAACACTGT
CTAATATGGTTCTGAGAGGTTCCAGGGCCTTTGTAGTCAATATCCAAGGGAAAAGCATCTCCGTTTCTCTGTGACCCAGGCCAGAAGCCT
GAGTGACCCATCCCTAAGGGCTTCTGGGCCAAACCTGGCAGCACCCACTGGGAATGAGATTTGGAACGGCCTCAGGAGCATAATGGCCAC
AGTTAGTAATGGTAAAGAGGGGATACCTTCTTAAACTGATAGACTTCCTGACTTCTTTCAGCAGGGTATTGTTTTAAATCAGCCTTGCAG
ATAAAAATTAATTCCATCTTTTTCAGACAAGTGAACAATTTAGTTCCTTGGCAGATCCAAAATGATAGATGGTTATGTTACGCTTTCTGC
TGTCCCTTGCCAAAAATAAGTAAATATATCAGTTAAGATTATGCCTTTACAAAAGTTAATTTACATTCTCTGTTTAAAAAATAATATTTG
GTGAATGCTATATAGTTGACAGAGCACATTTACAGACCTTATTAATTTAGTCTTTCCAAGAGACCTCTCATGTAACTGGCATTAGCCCCA
TTTTTAGATGATGAAACTGCAGTGCAGATGTTCTGGTTCTCTCAACTACCAAGTGGCATAACCCATGGATTTTCTAAAGGTTTCCCAAAT
AGATCACAACCTAAGGGTGTGCCAGGGGAGCCTAGGGGAAGCTAGGCTGGGCATTGAACACTGATAGTGCAGAATCCACATGCAAACAAG
ATCGACAGGGTGGATAAACATATATGTGCATTATCCCCATCCCCCACAGTTTAGAGCCTTCTGCTTTTCTGGGGGTTTCAGCCTATGAGA
CAAACTATAATCAGGCTTCATTATTACTTTTCAAATGGCCAAGGGTTATCTGCAATGTTGATCTAAAATCCTAAAAAATCACCCTGAAGT
CAGGCAAGGAACAATACTTAAACTCCATACTATGGAAACAAGGTATCTAGCTGGATGCAGCTGGTAAATTCAGTCCCATGGACCTTTGGG
GGTTTATTTTCCTTAGCAGCTGACACCATGTGTCTTTTGCATCCCTGGTGGTGCTTGGTGCTTCTGCCCATCTGGGCTCATTGAGAATAG
GGATGAAGATATGATTTTAGGGAATTTCTGATGGGCTGGCATGCCCCATGTAGTATGAGTTACTATATAAAGTCATGTGACTGGCATTTT
AACAGACCTTCCAGAGCTTATATATCCCAATATATGTTGTTTCCTTTGAGTAGCCCCAGCAGGATACTGCTTAGTTTTTCCAGTGCCATT
GGTGAAAGCATTTCTGGAACTGTCTTCAAAGACTAGAAACACTGACTCCCAAAATGCTAGAACTGGAAGGGACCTTAATGGTTATCTATT
CCAGCCTCCTCCTAAGGTCCTCCTCAGCTTCTAGACCTAGAAGCCAAAGTCCAGAACAGTGACCCATTGATCAAGGCAGATAGTATAACT
CCTTTTAAGTGTTCTCAGATTTGCCTTTTCTCAGGGCAAATCTTCAGTGTTTTGTGGTTATTTGTGGTTGAGAGAGAGAGAGAATGTAAT
GTCTGAGACTAGCCAGCAGCTATTTGAAGCCTCTGGGAAAGAAGGTGGCTTATCAAGTGGGTTTGTAGTAATGAGTGCTGCTGTAAAGCA
GAGCCATTTTCTTGTGCAGCTCATAGTTCCCAAACAGTTCCCAAACAGAAATTCCAGAGATGTCTTAAACATTGTGGTCATCATTGAGAT
AGGTGGAATCTCTTTGGTGACTACGTTGGTGGGGAACATCACTCACCTGAATGTATGCATTCTGTGTTCTCTGTGTGTGTGCACATATGC
AGATGTATGTTTTAAAAACATTTACCAAACTCATGATTTTGTAGTCACACCACTTCAGTTCTGGGCCCTACCAACAATTTATGTCCTCCA
AGAGCTGCTGGAGGGCATGTTTGTGCCCAAAACAGAAGAGCTGGCTCTGGTTTACAGAAGACAGGGAGGGTGACCTTACTATAAATGCCC
TTAGAGGAAACTTATCAGTTACTGCCATTTCACGCATTTCCTTTTTGATCTTAGTAAATATTATTGGAAGGCTAGTCTTGTTGGTAGGAG
CAAAGACACTTATTTTTCCACTTGCCATCTTTCTCTATATCTCCAGTAATTTGAAAAACACTTTTCAGTTGGAATTGATTTTTGTCTTTG
GTAAAAAGAAATATTTTTAATAGATAAAAGATATATATTTTAAATATTTCCCCAAATTAATACTTTCATTTTAAGAATTGCATAGCAGTT
GTAACAAGTGCAGAATGAAGAACAAATTCTTGTTAAGCAAATAGTCCAAACTCTAGGTCCAGCTTACTGCCTTCCCCCCTTGTACCTACA
GTGATGCCTAGGATGGTATTGACAGTTGTTTTCTAAACTTCCTGCTGAGCAACAGTCCTTCAAATATAGGTAGAGTGGTCTAGGTTAAGG
AGGGAGGAGGGTTGATCTTTAATCAGGTTGGCTTTGGAGGAAGGAAAAACCACTAAGGTATTATCTGAATTTTAAGATGCTTCCCATCCT
TAATAACTAAAACCTGAATGCTTTTCTTTCTGAAAAATCTCCCTCTCTCCTTCCATGATTCTGAAGTTGGTTAAAAGTCGATATGTTGAT
GTGTATTATTTGGGGGAACAGAAAAGGACAAGGAAGGAAACAGAACGATGGGAAGGGTTTGTGAGCTAGAATAAGAGGTGCAGGATTTCA
CAAAACAAATTCCTCACAAATCATTGAAGCCCAGTTCACCATACAAATTACCCATGTCTTACTCTGTTCCTTGTATATATGCATTCTGGG
TTTTTTTATTATTAAAGGGGAAGTTAGGGGGGAGGGTGAAGGTCAGTCTGAGGGGAAATCCAGGAAATGTGGTGCCCTTAGAAGGGGGCT
GTCAGCTCTTTTCCATAGAGAGGGAAAGAAACTTTGAGAAAATGTTCTTGACCCATTGATTGTATCTGCTGGAAGAAGTCATCTGGGCCT
GTTGGGTTGGTATCAGATCAGGGGATTATGCATCCAGCCCCTGGCCCCTTTAATCTATTTGCCTCTTTTTAAAAAAGGTTAAGTCTTCTT
GGGTGAGGCTTGCCAGGGAAACTCCTAAGTGGCTTCACTTATTTTTTAAATTTTAATTTAATTTTTAAATTTTTGCTTGGAAGCAGCACT
GGTAATAAATGTTTTATTTTTTGTTCATTTTCCCTAAAGGAAAAATGTCCTTAAGAGATTAAAGCTCTTAATTGATTACTGTCTGGTTAC
AAACTGGCAAACTGACTAAAATGGGAAGCTGCCACCGTGCCTGACTCATGTAGCTGATGACCGAAGGCTCATCCTTTCTTTTCTATTTGA
CAGACATTTACTGAGCTTCAGACTTGAGCCAACCCTGAGCTGGACTGTGGAGATAAAGCAGTTCCTGCTCTTGAGGAGCTCAATGTCTAA
TGGAATGCATTTGAATGTATGTGTGGCTGGAGAGTTCATTTATGGTCTTAGGAAAGCCATTTCTGGTCCCATTTAGAAAACTGACCAGCA
CCCAGCAAGCTGCATTCTACATTTTAGAGACCCCATTGGTATTTGTGAATTTGATTGCACCACCGCTTTTCCTTTACTAAGTAATGTTAT
GGAAGGAGAATGAATTTTCTCCTCTAGTGATTACAGGACATTAACATCTCTTCAGAAGCTGCTTTTAGCTTAAGCCCCAAGAAGTGAGGT
GGGTTGTGGATCACTGACATGGTCAGGGGAGGCCCACACCTCAATTCAGTAACCACCTAATCTCTCCCCCAACCTGATCTCTCATCAGAG
CTGGCAGCAACTTGGGATTCCTTTCCTTTTTCCTGCCTAACTTTTCATTGAAATGTCTAGTAGGAGAGTGAGAAAAGAGAACAAAGGCTG
GGTCACAGTCATAGAATGTTACAGCTGGAATGGGCATGGAAATCATCCAAGTTAAACTTCTTCTCTGCCCCCCGCCCCCACTTTTTTTTT
TTTTTTTTTTTAACCAAACGAACTTGTGATCCAGTGCCCTATTTTATAGTGTGGTTTTCCAGGGTCTGAATAAATAATCATTAAAGTTTG
ACACACGCAGACACACGCACCAATGATGGGGATACCCCCAAATGATTTAGGAGGTTATTTTATTTTAATAGTTTTTTCTTCCTGATTTTT
TTCAGTTAGTTAGAGTTAAATGTACCTATAGCCCCTGAATACATGCTCAGGTAGAGAAAGTCTCCATAGTATAAGTAAGTAATATGAATG
TGGAATCTTGGAAAGTGATATATTTTGATTGGAATAATTTTAATTAAATTTAATGATTTTAATTAAGAATTAAAAGCCAGCTAGCCAAAT
TTTCTTTAAAAATTGGAAACTCATTATGGTCTTAAATTGTCCTCAGGCAGCCTTTTCCTCATCAACCCATAGAGTGGTCTTTTGAACTGG
TATCTAAACATACCTGGTTATGAATTCTCAAAAGAGAAAGCAGGTCTGGGGCGGGGTGGTCAGGAGACAGATTCTAGGGAAAGTGCTGAA
GAGATTTTCTTCTGAAGATGATCTAGGAAATGCATCTTTATACATGATTGTTAGCTGCTGTAGCTTTCTGAAGAAGATTGTAGAAAAGAG
ACTAAGATATATGCAAGGGTCACCAGTTTAGAGATCAGTCAAATTGGAAAAAGTGCCAAGACTGGATGTGCAGATTGTTCTATGTATTAT
CAGTATTTTTTTCCTCTTAAGAAAAAAATTTACTCTCTCTCCTTTGTGAGTAAATGCCTCCTTAATGCCTTTTAAGTAAGGTGGCAACTT
TTAACTGTCATCTTGTGAGAGGCAACCTCAAACTCTAAGCAGACTCCCTCTCTCCCTTTCTGGTGTCTTAAATCAAGAACTAGTTTGAAG
CCAAGGCAAAGCAAGGTTTGTTCATCTTCCTTTCCTGTCATTTAAGGTAAAACAGGCAATGAACTCGCTCTTCAAATACCATAGTTCAAG
AGTAGCTGTTGGCCCTGGTTCCAGATTAATATAGCAGCAGGCAGATTGCCCCTTCTTGGGGCCACCACCCTCCAAAGCTGTGCCACCAAT
GAGAGCATTGGGTTCAAGTTTGCATCAAACATGGTATTACCAACGCTGAGCCTCCAGCAGAGCACTTAAAAGTCCTAGTGAGAGAATAGA
TACTATGCAAGGGAAAAAAATTTAAATGCCAACGAATAGTTTTTTTTTTTTTGAACCTGATACACTGTTTGTTTACTCTCAACTCTTTGT
ACAAATATTATTGTCCTAAGGGCCTTTTCCCCTCCTGCCTAGAAAATAGGTTGTGTATTGGTTTTATTCAACCTGCTGTCTGCTTTAGGA
TTGGAGAAGGTACCTGGATCCTTGTGGACTGCCACTGCTGGCTGCCTCCTCTCCAACTCATCAGAAGAGCATTTTGACAAAGACAGAGGA
CTTGGACCAGGGCATGCCCTGTTGGGGATGTTTCTGTCAGCAAGGACATGGCATGGAATCAAGTGGGCTGATGTGTTGTTATTTAAACAG

>66901_66901_5_POLD3-RNF169_POLD3_chr11_74347320_ENST00000532497_RNF169_chr11_74500670_ENST00000299563_length(amino acids)=856AA_BP=2
MEAVKSKLAVTASIHVYSIQKAMLKDSGPLFNTDYDILKSNLQNCSKFSAIQCAAAVPRAPAESSSSSKKFEQSHLHMSSETQANNELTT
NGHGPPASKQVSQQPKGIMGMFASKAAAKTQETNKETKTEAKEVTNASAAGNKAPGKGNMMSNFFGKAAMNKFKVNLDSEQAVKEEKIVE
QPTVSVTEPKLATPAGLKKSSKKAEPVKVLQKEKKRGKRVALSDDETKETENMRKKRRRIKLPESDSSEDEVFPDSPGAYEAESPSPPPP
PSPPLEPVPKTEPEPPSVKSSSGENKRKRKRVLKSKTYLDGEGCIDFIFRAPIKLSKPGELREEYESLRKLREEKLQEEKPSEDQIHKLL
PEDTETGKRKMDEQKKRDEPLVLKTNLERCPARLSDSENEEPSRGQMTQTHRSAFVSKNNSYSLAFLAGKLNSKVERSQSCSDTAQERAK
SRVRAVPGNKAKVTTMTPASNPIIGVLLSTQNNRCVSAPDLTIEKRLPFSSLSSLASLHKPERSVSPESNDSISEELNHFKPIVCSPCTP
PKRLPDGRVLSPLIIKSTPRNLNRSLQKQTSYEASPRILKKWEQIFQERQIKKTLSKATLTSLAPEMGEELLGSEGIHSSKEKPLVAVNT
RLSGGQVLSEYTGPTSADLDHFPSVSQTKAEQDSDNKSSTEIPLETCCSSELKGGGSGTSLEREQFEGLGSTPDAKLDKTCISRAMKITT
VNSVLPQNSVLGGVLKTKQQLKTLNHFDLTNGVLVESLSEEPLPSLRRGRKRHCKTKHLEQNGSLKKLRQTSGEVGLAPTDPVLREMEQK

--------------------------------------------------------------
>66901_66901_6_POLD3-RNF169_POLD3_chr11_74347320_ENST00000532497_RNF169_chr11_74500671_ENST00000299563_length(transcript)=8457nt_BP=1149nt
GCTGTGGCTGTGATTGAGAGAGGGGTTAGAGGCGGGTCCCAGCGCTGCCGCACCATGGCGGACCAGCTTTATCTGGAAAATATAGACGAG
TTCGTCACGGACCAAAACAAGATCGTGACATACAAATGGCTGAGCTATACACTAGGGGTTCATGTTAACCAGGCCAAACATGCCACAAGG
TTGCAGTAGTGAGAGAAGATAAATTGGAAGCAGTGAAGTCCAAGCTAGCTGTGACTGCCAGCATCCATGTGTACAGCATCCAGAAAGCCA
TGCTAAAGGACAGTGGGCCTCTGTTCAATACTGACTATGACATCCTTAAAAGCAACTTGCAGAACTGCAGCAAATTTAGTGCTATACAAT
GTGCAGCTGCCGTCCCTAGAGCTCCTGCTGAATCCTCTTCGTCTTCCAAAAAGTTTGAGCAGTCACATCTTCACATGTCAAGTGAGACAC
AAGCCAACAATGAGCTGACCACCAATGGTCATGGCCCACCTGCATCCAAGCAGGTTTCCCAGCAGCCCAAAGGAATTATGGGAATGTTTG
CCTCCAAAGCTGCTGCTAAAACCCAAGAAACCAACAAGGAAACGAAAACAGAGGCTAAAGAAGTAACAAATGCATCTGCAGCAGGCAACA
AGGCACCAGGGAAAGGGAATATGATGAGCAACTTTTTTGGAAAAGCTGCTATGAATAAATTTAAAGTCAATTTGGACTCAGAACAAGCAG
TGAAAGAAGAAAAAATAGTGGAGCAGCCTACAGTGTCTGTCACGGAACCAAAGCTGGCAACTCCTGCAGGCCTGAAAAAATCCAGCAAAA
AAGCAGAGCCTGTTAAGGTGCTGCAGAAGGAAAAAAAAAGGGGGAAGCGAGTAGCATTATCTGATGATGAGACAAAGGAAACTGAAAACA
TGAGGAAAAAGAGGAGAAGAATCAAACTTCCTGAATCTGATAGCAGTGAAGATGAAGTCTTTCCAGACTCTCCTGGGGCTTATGAAGCTG
AGTCACCATCCCCACCTCCTCCTCCGTCTCCACCTCTTGAACCAGTGCCAAAGACTGAGCCTGAACCTCCTTCTGTCAAGAGCTCAAGTG
GAGAAAACAAAAGAAAACGAAAACGCGTACTAAAATCTAAAACTTACCTGGATGGGGAAGGCTGCATAGACTTTATATTCAGAGCACCAA
TCAAATTAAGCAAGCCTGGGGAACTTCGTGAGGAATATGAAAGCTTGAGAAAGCTGAGAGAAGAAAAGTTACAAGAGGAAAAACCCTCTG
AAGATCAAATCCACAAGCTGTTACCAGAGGATACAGAAACAGGGAAAAGGAAAATGGATGAACAGAAAAAAAGAGATGAACCATTAGTAC
TGAAAACAAATCTGGAACGTTGTCCTGCACGTCTCTCAGATTCAGAGAATGAAGAACCTTCTCGAGGCCAGATGACACAGACACATCGCT
CGGCATTTGTTTCCAAGAACAACTCCTACTCCTTAGCTTTCCTGGCAGGGAAGCTAAACTCCAAGGTGGAAAGGAGTCAGAGCTGTAGTG
ACACAGCCCAGGAAAGAGCGAAGAGCAGAGTCAGAGCAGTTCCAGGCAACAAAGCCAAGGTCACAACTATGACTCCAGCCTCCAACCCCA
TCATTGGTGTCCTCTTGTCAACTCAAAACAACCGCTGCGTCTCGGCCCCTGACTTAACCATCGAAAAGCGTCTACCCTTCAGCTCCCTTT
CATCCTTGGCTTCCCTGCATAAGCCAGAGCGTTCTGTCAGCCCTGAGAGCAATGACAGCATCTCCGAAGAACTAAACCATTTCAAGCCCA
TTGTCTGCTCACCATGTACTCCTCCCAAGAGACTCCCTGATGGCCGTGTGCTAAGTCCTCTCATCATCAAATCAACTCCACGCAACCTAA
ACAGAAGCCTGCAGAAGCAGACTTCTTATGAGGCCAGTCCACGGATCCTCAAAAAGTGGGAACAGATCTTTCAGGAGCGGCAGATCAAAA
AGACCCTTTCAAAAGCCACTCTTACCTCTCTGGCTCCTGAAATGGGGGAAGAGTTACTAGGCTCTGAAGGTATCCATTCTAGCAAGGAGA
AGCCACTTGTGGCTGTAAATACAAGATTATCTGGTGGGCAGGTCCTCTCTGAGTATACTGGACCCACCTCTGCTGATCTTGATCATTTCC
CCTCTGTTAGCCAAACAAAAGCAGAACAGGACAGTGATAATAAAAGTAGCACTGAGATCCCACTGGAAACCTGCTGTTCCTCAGAACTCA
AAGGGGGAGGCAGTGGGACTTCTTTGGAGAGGGAGCAGTTTGAGGGGTTAGGGTCAACTCCAGATGCCAAGTTAGACAAAACCTGTATAA
GCAGAGCCATGAAAATCACCACAGTTAATTCAGTGCTACCCCAAAACAGTGTTTTGGGTGGAGTCCTCAAAACAAAGCAACAATTGAAGA
CATTAAATCATTTTGATCTGACTAATGGTGTTCTAGTTGAGAGCCTAAGTGAAGAGCCACTTCCTTCTTTGCGTCGAGGCCGGAAAAGAC
ACTGCAAGACCAAGCACTTAGAACAAAATGGCTCCCTTAAAAAACTGCGACAAACCAGTGGGGAGGTGGGTCTGGCCCCAACAGACCCAG
TCCTGCGAGAGATGGAGCAGAAGCTTCAGCAAGAGGAAGAAGACCGACAGTTGGCTCTGCAGTTGCAGCGCATGTTCGACAATGAGAGGC
GGACTGTGAGCCGGCGAAAAGGAAGTGTGGATCAGTATCTCCTACGGTCCAGCAACATGGCCGGGGCCAAGTAGCACCTAATGAAGTGTT
ACCTATTTTTAAAAGGTCTTAGGCCTTGATCATTTATCCTGAAGAGCTGAGTGTTCTCACTTTGGTTTTATTTTAATGGCAAAACACTGT
CTAATATGGTTCTGAGAGGTTCCAGGGCCTTTGTAGTCAATATCCAAGGGAAAAGCATCTCCGTTTCTCTGTGACCCAGGCCAGAAGCCT
GAGTGACCCATCCCTAAGGGCTTCTGGGCCAAACCTGGCAGCACCCACTGGGAATGAGATTTGGAACGGCCTCAGGAGCATAATGGCCAC
AGTTAGTAATGGTAAAGAGGGGATACCTTCTTAAACTGATAGACTTCCTGACTTCTTTCAGCAGGGTATTGTTTTAAATCAGCCTTGCAG
ATAAAAATTAATTCCATCTTTTTCAGACAAGTGAACAATTTAGTTCCTTGGCAGATCCAAAATGATAGATGGTTATGTTACGCTTTCTGC
TGTCCCTTGCCAAAAATAAGTAAATATATCAGTTAAGATTATGCCTTTACAAAAGTTAATTTACATTCTCTGTTTAAAAAATAATATTTG
GTGAATGCTATATAGTTGACAGAGCACATTTACAGACCTTATTAATTTAGTCTTTCCAAGAGACCTCTCATGTAACTGGCATTAGCCCCA
TTTTTAGATGATGAAACTGCAGTGCAGATGTTCTGGTTCTCTCAACTACCAAGTGGCATAACCCATGGATTTTCTAAAGGTTTCCCAAAT
AGATCACAACCTAAGGGTGTGCCAGGGGAGCCTAGGGGAAGCTAGGCTGGGCATTGAACACTGATAGTGCAGAATCCACATGCAAACAAG
ATCGACAGGGTGGATAAACATATATGTGCATTATCCCCATCCCCCACAGTTTAGAGCCTTCTGCTTTTCTGGGGGTTTCAGCCTATGAGA
CAAACTATAATCAGGCTTCATTATTACTTTTCAAATGGCCAAGGGTTATCTGCAATGTTGATCTAAAATCCTAAAAAATCACCCTGAAGT
CAGGCAAGGAACAATACTTAAACTCCATACTATGGAAACAAGGTATCTAGCTGGATGCAGCTGGTAAATTCAGTCCCATGGACCTTTGGG
GGTTTATTTTCCTTAGCAGCTGACACCATGTGTCTTTTGCATCCCTGGTGGTGCTTGGTGCTTCTGCCCATCTGGGCTCATTGAGAATAG
GGATGAAGATATGATTTTAGGGAATTTCTGATGGGCTGGCATGCCCCATGTAGTATGAGTTACTATATAAAGTCATGTGACTGGCATTTT
AACAGACCTTCCAGAGCTTATATATCCCAATATATGTTGTTTCCTTTGAGTAGCCCCAGCAGGATACTGCTTAGTTTTTCCAGTGCCATT
GGTGAAAGCATTTCTGGAACTGTCTTCAAAGACTAGAAACACTGACTCCCAAAATGCTAGAACTGGAAGGGACCTTAATGGTTATCTATT
CCAGCCTCCTCCTAAGGTCCTCCTCAGCTTCTAGACCTAGAAGCCAAAGTCCAGAACAGTGACCCATTGATCAAGGCAGATAGTATAACT
CCTTTTAAGTGTTCTCAGATTTGCCTTTTCTCAGGGCAAATCTTCAGTGTTTTGTGGTTATTTGTGGTTGAGAGAGAGAGAGAATGTAAT
GTCTGAGACTAGCCAGCAGCTATTTGAAGCCTCTGGGAAAGAAGGTGGCTTATCAAGTGGGTTTGTAGTAATGAGTGCTGCTGTAAAGCA
GAGCCATTTTCTTGTGCAGCTCATAGTTCCCAAACAGTTCCCAAACAGAAATTCCAGAGATGTCTTAAACATTGTGGTCATCATTGAGAT
AGGTGGAATCTCTTTGGTGACTACGTTGGTGGGGAACATCACTCACCTGAATGTATGCATTCTGTGTTCTCTGTGTGTGTGCACATATGC
AGATGTATGTTTTAAAAACATTTACCAAACTCATGATTTTGTAGTCACACCACTTCAGTTCTGGGCCCTACCAACAATTTATGTCCTCCA
AGAGCTGCTGGAGGGCATGTTTGTGCCCAAAACAGAAGAGCTGGCTCTGGTTTACAGAAGACAGGGAGGGTGACCTTACTATAAATGCCC
TTAGAGGAAACTTATCAGTTACTGCCATTTCACGCATTTCCTTTTTGATCTTAGTAAATATTATTGGAAGGCTAGTCTTGTTGGTAGGAG
CAAAGACACTTATTTTTCCACTTGCCATCTTTCTCTATATCTCCAGTAATTTGAAAAACACTTTTCAGTTGGAATTGATTTTTGTCTTTG
GTAAAAAGAAATATTTTTAATAGATAAAAGATATATATTTTAAATATTTCCCCAAATTAATACTTTCATTTTAAGAATTGCATAGCAGTT
GTAACAAGTGCAGAATGAAGAACAAATTCTTGTTAAGCAAATAGTCCAAACTCTAGGTCCAGCTTACTGCCTTCCCCCCTTGTACCTACA
GTGATGCCTAGGATGGTATTGACAGTTGTTTTCTAAACTTCCTGCTGAGCAACAGTCCTTCAAATATAGGTAGAGTGGTCTAGGTTAAGG
AGGGAGGAGGGTTGATCTTTAATCAGGTTGGCTTTGGAGGAAGGAAAAACCACTAAGGTATTATCTGAATTTTAAGATGCTTCCCATCCT
TAATAACTAAAACCTGAATGCTTTTCTTTCTGAAAAATCTCCCTCTCTCCTTCCATGATTCTGAAGTTGGTTAAAAGTCGATATGTTGAT
GTGTATTATTTGGGGGAACAGAAAAGGACAAGGAAGGAAACAGAACGATGGGAAGGGTTTGTGAGCTAGAATAAGAGGTGCAGGATTTCA
CAAAACAAATTCCTCACAAATCATTGAAGCCCAGTTCACCATACAAATTACCCATGTCTTACTCTGTTCCTTGTATATATGCATTCTGGG
TTTTTTTATTATTAAAGGGGAAGTTAGGGGGGAGGGTGAAGGTCAGTCTGAGGGGAAATCCAGGAAATGTGGTGCCCTTAGAAGGGGGCT
GTCAGCTCTTTTCCATAGAGAGGGAAAGAAACTTTGAGAAAATGTTCTTGACCCATTGATTGTATCTGCTGGAAGAAGTCATCTGGGCCT
GTTGGGTTGGTATCAGATCAGGGGATTATGCATCCAGCCCCTGGCCCCTTTAATCTATTTGCCTCTTTTTAAAAAAGGTTAAGTCTTCTT
GGGTGAGGCTTGCCAGGGAAACTCCTAAGTGGCTTCACTTATTTTTTAAATTTTAATTTAATTTTTAAATTTTTGCTTGGAAGCAGCACT
GGTAATAAATGTTTTATTTTTTGTTCATTTTCCCTAAAGGAAAAATGTCCTTAAGAGATTAAAGCTCTTAATTGATTACTGTCTGGTTAC
AAACTGGCAAACTGACTAAAATGGGAAGCTGCCACCGTGCCTGACTCATGTAGCTGATGACCGAAGGCTCATCCTTTCTTTTCTATTTGA
CAGACATTTACTGAGCTTCAGACTTGAGCCAACCCTGAGCTGGACTGTGGAGATAAAGCAGTTCCTGCTCTTGAGGAGCTCAATGTCTAA
TGGAATGCATTTGAATGTATGTGTGGCTGGAGAGTTCATTTATGGTCTTAGGAAAGCCATTTCTGGTCCCATTTAGAAAACTGACCAGCA
CCCAGCAAGCTGCATTCTACATTTTAGAGACCCCATTGGTATTTGTGAATTTGATTGCACCACCGCTTTTCCTTTACTAAGTAATGTTAT
GGAAGGAGAATGAATTTTCTCCTCTAGTGATTACAGGACATTAACATCTCTTCAGAAGCTGCTTTTAGCTTAAGCCCCAAGAAGTGAGGT
GGGTTGTGGATCACTGACATGGTCAGGGGAGGCCCACACCTCAATTCAGTAACCACCTAATCTCTCCCCCAACCTGATCTCTCATCAGAG
CTGGCAGCAACTTGGGATTCCTTTCCTTTTTCCTGCCTAACTTTTCATTGAAATGTCTAGTAGGAGAGTGAGAAAAGAGAACAAAGGCTG
GGTCACAGTCATAGAATGTTACAGCTGGAATGGGCATGGAAATCATCCAAGTTAAACTTCTTCTCTGCCCCCCGCCCCCACTTTTTTTTT
TTTTTTTTTTTAACCAAACGAACTTGTGATCCAGTGCCCTATTTTATAGTGTGGTTTTCCAGGGTCTGAATAAATAATCATTAAAGTTTG
ACACACGCAGACACACGCACCAATGATGGGGATACCCCCAAATGATTTAGGAGGTTATTTTATTTTAATAGTTTTTTCTTCCTGATTTTT
TTCAGTTAGTTAGAGTTAAATGTACCTATAGCCCCTGAATACATGCTCAGGTAGAGAAAGTCTCCATAGTATAAGTAAGTAATATGAATG
TGGAATCTTGGAAAGTGATATATTTTGATTGGAATAATTTTAATTAAATTTAATGATTTTAATTAAGAATTAAAAGCCAGCTAGCCAAAT
TTTCTTTAAAAATTGGAAACTCATTATGGTCTTAAATTGTCCTCAGGCAGCCTTTTCCTCATCAACCCATAGAGTGGTCTTTTGAACTGG
TATCTAAACATACCTGGTTATGAATTCTCAAAAGAGAAAGCAGGTCTGGGGCGGGGTGGTCAGGAGACAGATTCTAGGGAAAGTGCTGAA
GAGATTTTCTTCTGAAGATGATCTAGGAAATGCATCTTTATACATGATTGTTAGCTGCTGTAGCTTTCTGAAGAAGATTGTAGAAAAGAG
ACTAAGATATATGCAAGGGTCACCAGTTTAGAGATCAGTCAAATTGGAAAAAGTGCCAAGACTGGATGTGCAGATTGTTCTATGTATTAT
CAGTATTTTTTTCCTCTTAAGAAAAAAATTTACTCTCTCTCCTTTGTGAGTAAATGCCTCCTTAATGCCTTTTAAGTAAGGTGGCAACTT
TTAACTGTCATCTTGTGAGAGGCAACCTCAAACTCTAAGCAGACTCCCTCTCTCCCTTTCTGGTGTCTTAAATCAAGAACTAGTTTGAAG
CCAAGGCAAAGCAAGGTTTGTTCATCTTCCTTTCCTGTCATTTAAGGTAAAACAGGCAATGAACTCGCTCTTCAAATACCATAGTTCAAG
AGTAGCTGTTGGCCCTGGTTCCAGATTAATATAGCAGCAGGCAGATTGCCCCTTCTTGGGGCCACCACCCTCCAAAGCTGTGCCACCAAT
GAGAGCATTGGGTTCAAGTTTGCATCAAACATGGTATTACCAACGCTGAGCCTCCAGCAGAGCACTTAAAAGTCCTAGTGAGAGAATAGA
TACTATGCAAGGGAAAAAAATTTAAATGCCAACGAATAGTTTTTTTTTTTTTGAACCTGATACACTGTTTGTTTACTCTCAACTCTTTGT
ACAAATATTATTGTCCTAAGGGCCTTTTCCCCTCCTGCCTAGAAAATAGGTTGTGTATTGGTTTTATTCAACCTGCTGTCTGCTTTAGGA
TTGGAGAAGGTACCTGGATCCTTGTGGACTGCCACTGCTGGCTGCCTCCTCTCCAACTCATCAGAAGAGCATTTTGACAAAGACAGAGGA
CTTGGACCAGGGCATGCCCTGTTGGGGATGTTTCTGTCAGCAAGGACATGGCATGGAATCAAGTGGGCTGATGTGTTGTTATTTAAACAG

>66901_66901_6_POLD3-RNF169_POLD3_chr11_74347320_ENST00000532497_RNF169_chr11_74500671_ENST00000299563_length(amino acids)=856AA_BP=2
MEAVKSKLAVTASIHVYSIQKAMLKDSGPLFNTDYDILKSNLQNCSKFSAIQCAAAVPRAPAESSSSSKKFEQSHLHMSSETQANNELTT
NGHGPPASKQVSQQPKGIMGMFASKAAAKTQETNKETKTEAKEVTNASAAGNKAPGKGNMMSNFFGKAAMNKFKVNLDSEQAVKEEKIVE
QPTVSVTEPKLATPAGLKKSSKKAEPVKVLQKEKKRGKRVALSDDETKETENMRKKRRRIKLPESDSSEDEVFPDSPGAYEAESPSPPPP
PSPPLEPVPKTEPEPPSVKSSSGENKRKRKRVLKSKTYLDGEGCIDFIFRAPIKLSKPGELREEYESLRKLREEKLQEEKPSEDQIHKLL
PEDTETGKRKMDEQKKRDEPLVLKTNLERCPARLSDSENEEPSRGQMTQTHRSAFVSKNNSYSLAFLAGKLNSKVERSQSCSDTAQERAK
SRVRAVPGNKAKVTTMTPASNPIIGVLLSTQNNRCVSAPDLTIEKRLPFSSLSSLASLHKPERSVSPESNDSISEELNHFKPIVCSPCTP
PKRLPDGRVLSPLIIKSTPRNLNRSLQKQTSYEASPRILKKWEQIFQERQIKKTLSKATLTSLAPEMGEELLGSEGIHSSKEKPLVAVNT
RLSGGQVLSEYTGPTSADLDHFPSVSQTKAEQDSDNKSSTEIPLETCCSSELKGGGSGTSLEREQFEGLGSTPDAKLDKTCISRAMKITT
VNSVLPQNSVLGGVLKTKQQLKTLNHFDLTNGVLVESLSEEPLPSLRRGRKRHCKTKHLEQNGSLKKLRQTSGEVGLAPTDPVLREMEQK

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Fusion Gene PPI Analysis for POLD3-RNF169


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for POLD3-RNF169


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for POLD3-RNF169


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource